Document 3JX8YpO0dk6gveXKkOD2LMrLJ

tV,* ^A gift ^liwfe^ *?:- 1 JLemU Haidranlrfcr^ AssooIfitSoia.liQo. jmmn a imv ia ma mh m MaNrTtd *. VIM MMUMI iwO* ^ v*m r*i*** d** I. T*A*fc, M MM > a m t. iuncr *V| M. aa MADItON AVKNUK xrw TOHX. k . t . looir MCA COM CIC ee mm July-lb, 1966 Pennsylvania State Air Pollution Control Camisdoa e/o Departaent of Health Division of Air Pollution Control Poet Offie* Box 90 H*rribur{, F. 17101 Gentleneaj Ve hat* been advised that your Caxtissloo ia coaalderm* the driftlac of clr quality criteria, inc Indie.-. o*e for lead. V* vould, therefore, lifce to infora you of r --ch jsro^rar-5 which the lead industry ha* under vay ud vfaia concerned vvth lav Icwl expciure* of the kind likely t~ _jr in the lab lent ataoepnere and vdticn tn declined to pror... scientific B.tjvrrj to quectloc* likely to *ri* when crit, *1* are iel.-xj determined. About four year* ego acnoer* of the lead industry and the U.,3. Public Health Service agreed that it vould 0* it tc -ein a project, or project*, which vould lead to ansv...-* to the question *4 to vb*t effect lev level exposure to let! v o l U. have eo the busan eyttca sod to attempt to quantitate eveb exposure* In terra of concentration of lead la *lr. The Kettering laboratory ret up *0 experimental protocol the. vould u*e busan volunteer* in expocur* chamber* end expo** the * volunteer* to lov level, and increasing aacunt* of le4 in air. The level* of lead nalntsined in the*# lahalatloo chasber* vould be progressively increased la suitable locreseot* of .*-vc#atrtloa end tine. In order to tect whether or not uch an e,,. riaent vould (lee significant recull*, the flret phase attempted to eMur* the effect of continuous expoeure t 150 alcrcgrwo* per .uoic neter of *lr. You vill reaenner tht 150 icrognu* per . J>1 a# ter of *1r va* the old industrial hygiene expo#..-# 1 iait for eight hour* * day, Thl* phase of the experiment va* cco* pleted and chtved uat when buaaa being* are exposed continuously ;o .>0 aUrcgraa* per cut 14 a*ter of lead la air, la soeevfest ilfcLJ C%*'4' : -^"' -^?.v`"' vv'^;i"-"'` ' ' =*'- *:' Vs ',' -ijc;ssaay-*as.'- >^~V *- '.rV -%?* ' ' -<''M ,- ''lifiSiftnS ffirMstfiilrlfrr* u, .... ,.uiti...aiew-.. w.->auna';ia4-u.-iu-~uw page Two } ,~ Pennsylvania State Air Pollutico Control Coeds* loo 1 over tvo year* blood lead level* would reach 80 olcrograas per cent, which 1* the Unit prescribed by Dr. Xehoe below which clinical fconifestatlon* ere not found. The coat Important reasoa for performing this first phase vae to teat the aethod snd to determine whether It could provide significant results vihcwt V* necessity of confining a human subject In an expoaur* chamber for 2b hour* a day. Here is a brief outUne of the experimental nethod that vaa used] First an exposure of two hours a day until equilibrium values of lead In blood were reached, then four hours a day until equlllbrlua values of lead In blood were reached, then eight hours a day and finally sixteen hours a day. Using these equilibrium blood values as points on sn exposure curve It v* possible to ex trapolate the curve to the point of twenty four hours s day. This satisfied us that the us* of incremental tines gave significant results, result* vhlch coincide with those obtained In ether human exposure studies. Each of these experiments requires st least cue year to couplet* and u# are now la o-r third year of operating this study. V* now have two sen being exposed In inhalation chancer* and plan to coctlnu* the study until significant and reproducible result* have been obtained. Financial support for these studies, as veil a* several other Inhalation chancer studies using rats as confirmation, is provibad by bhe lead in-wiry, T.-. .iesa Petroleum Inuli".... and the United States Public Health Seme*. The State Health Seport * xent in California has agreed vith us that these are valuable experlnents and that the results will be of great Interest to them when they are ready to detemine air quality criteria for lead. Vo, therefore, suggest to your Corel*sloe, that the results of these experiments will be of oqnal value to you in the determination of rational and scientific air quality criteria. This study is being performed in the public Interest and the J results will be node known to all interested parties. Thus far sufficient data ha* not been accumulated to provide a owner, or rwi.ri, that would be of scientific signifi ,:i cance. Ve have assumed that air quality criteria for thhio * rate rial* should be derived free, data tost Is significant in terns of human health. Our stxiie* ere unique is the field of eir pollution, are of course exceedingly expensive la te;*.e of dollars, but, wn*t is scat important, clve w res'ults that u.rsctly relate to huraa phy* lolcuqy, results that do not have to be extrap -I olated fries one animal species to another. ,- `! . "d-- it r - \'-xv affillM8IWaBBBWaa9W^^ ra-^'-eJiv. isq'i.'.-E'Uw; '-aweas. p b i* r gwrr %0t i 'BW"W igftt 'P-** ** **> mmmmwwm*? mi LIA11834 W^'gf'|: + * *,miwmmvrrrr* Page Three Pennsylvania State Air Pollution Control CosclsslOQ The lead Industry has in the past, and will continue in the future, to act in a resperm Id de manner and vill cooperate vlth all Interested Government and private eecneieo in evaluation of lend and tr.c p-nlic health. Our industry and it* members have spent r--..y millions of dollars on the evaluation of the relationship of lead to problems of health: therefore, ve believe we are in a position to ash your cooperation, and to cooperate vith you in the establishment of scientific end reasonable air quality standards. In our opinion one cf the most important activities of Government agencies in the field of air conservation and pollution control i* tne establishment of reasonable air quality criteria. Too report of the research Kanagesent Advisory Panel to the Committee cc Science and Astronautics cf the U. S. House of Representatives, which is entitled "Che Adequacy cf Ceohrolopy for Pollution Abatement", nates the following statement which is pertinent to our discussion here: Oaee the goals of pollution abatement are agreed on, attention can be directed to the equally important questions of how the goals can be attained most effectively, and who should pay the costs of measures to bring about the desired conditions. Che Panel believes that science and technology crust play an importer,t rod* in finding answers to ail of these questions. C*j 1s that ara not la h artery viv, the c -1 <- rt" >c underlying _.t field rAy rvver be attained. Very truly yours, I*oo 0. Fowler S S' i i icrjjb j Kr. Allen 0- randt Kr. Victor f. Sussaan 9 * 'Msa^yrrw'yjyjww1 Hi'siwmwi*es,Tr,4t.-;^eeH!.!SjT'.'leaBWjBfW 0 i iMiiufwi i m imiiL^Mi.nmuri- .. im*