Document 3J2Yx8BxGBQ8GanGKJ4MKLyMO

FOR^fi' PONT USE ONLY AR226-2888 E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 Study Initiated/Completed 7/15/80 - 7/18/80 Material Submitted by Jackson Laboratory EYE IRRITATION TEST IN RABBITS Procedure: One hundred mg of solid test material was placed into the right conjunctival sac of each of 2 male albino rabbits.** After 20 seconds, 1 treated eye was washed with tap water for 1 minute. The treated eye of the other rabbit was not washed. Observations of the cornea, iris and conjunctiva were made with a hand-slit lamp at 1 and 4 hours, and at 1, 2, and 3 days; Fluor-- i-strip stain and a biomicroscope were used at examinations after the day of treatment. Results: '~ ' ~ Dose Treatment 100 mg Not Washed undiluted test material 100 mg. Washed undiluted test material ______________ Ocular Effects ______ Cornea Iris ______ Conjunctiva______ None None Redness: None Swelling:None Discharge:Mild 4 hrs. None None . Redness: Mild 1-4 hrs. Swelling:Slight 1-4 hrs. Discharge:Moderate 1 hr., mild 4 hrs. Company Sanitized. Does not contain TSCA CBI __ ^ ^ ^ ^ t a u s e d transient mild conjunctivitis, no corneal effectB, and no ww Sl rneKnsS stte d in the eye of a rabbit. An eye dosed with the test material a(>A piomptly washed had transient moderate to slight conjunctivitis, no corneal effects, and no Iritis. Both eyes were normal within 1 day. This material is a mild eye irritant and should be flushed with copious amounts of water if eye contact occurs. Report by: Polly Biochemist Approved by: if " V Gerald L. Kennedy Chief, Acute Investigations Section P A :jrg Study Director: 0. L. Dashiell Date Iaimert- T.ilv V). 1980 Report No. 572-80 Company Sanitized. Doss not contain TSCA CB