Document 37zdk80NRMZ9N9Z3xV0626k5y

FILE NAME: Raybestos-Manhattan (RBM) DATE: 1972 Nov 10 DOC#: RBM029 DOCUMENT DESCRIPTION: Letter from Dr. Goodman to RaybestosManhattan RE Asbestos leads to Asbestosis and Carcinoma of the Lung JOSEPH L. GOOD: M. D. 3 3 0 `HCAr. A 7 c ::./2 NORTH CHARLCSTC.'I. C. 3 4 0 0 Novem ber 10, 1972 2 PLAINTIFF S EXHIBIT P7^d : A fs Mr. William S. Simpson, President Raybestos-Manhattan, Inc. 205 Middle Street Bridgeport, Connecticut 06603 Dear Mr. Simpson: This is a review of the meeting in Lyon, Trance, the subject of which w as the B iological E ffects of A sb e sto s. The real purpose and im p or tance ox th is m eeting seem s to indics.ie to me that there is a distinct trend in the thought of people internationr .Uy associated with the bio lo g ica l effects of a sb estos in its relation:hip to d isea se, m ainly a sb e sto&is, and to a great or extent its sign ificant effect on the individual in relationship to cancer. The translation of this knowledge into future efforts by Raybe stos-M an hattan Corporation and its m edical personnel in relationship to the sc ie n tists, the public, and to the governm ent rem ains to be evaluated. 1 think it would be appropriate to d isc u ss the future trends and the course o f action that w as being taken by a ll p a rties concerned in this discussion. At the p resen t tim e, there is no doubt - ro question - that the biological effects of a sb esto s lead s to a sb e s to s is a n i to carcinom a of-the lung; both' bronchogenic carcinom a and m esotheliom a. As far a s the different aspects of the effect of different types of asbestos arc concerned, ail types o i a sb estos are incrim inated. T here w ere papers presented which show that m esoth eliom a is caused by crccid o litc, am ositc, and enrysot:le. These particular cancers of the iur.j arc of extrem e importance and lately have been given national and i:r creational publicity. C onsideration is being given to the i:v ec .*gtions that wc arc pursuing rela tiv e to the p o ssib ility that other typer of tum ors of the body m?.y have a relationship to a sb esto s c l o s u r e . TI-: ; r.t the present tim e is not firm , but there was shown at this particular r..:*:ting that th ere is a trend lev. ..vd this direction relative to gas^ro-intesvir.r tumors and p ossib ly other c/pes of rare tum ors, such as the p an creas, :;a agua, parts of the colon, and duo:* parts oi the in teu lin al tra ct. Yi.i ? n point of view which war. not been previously recu^alcvu. fh c bro.........and m edical implication;; of this lie iU.iv lyp wi environ m ental r.. -are is eM vum eiy iuiporuni because wo nww se e ihu i-viplication.-: :: : - duional publicity affecting ail organs of the body, ai chough i wis true the resp iratory system ia a m ajor prim ary organ oi ht. 1.tiy which ' ' ffccted. The company* a con cern, '- ir'a concern, .'* Ihrr ' no' concern, ar. fih r o v r iT il__ .,! M l J i l e <*.`t '* nni.i n , i n - w v <> in liy H** in l'e in - t'.iI j<.<lui.li y uni n i . 'u i . t '. n A U ni) ' imii.o<t triy re* .i^ niue tiie imjwirUujce of such r e le a s e s in the p ro s . (More) 01379 2 iL i I don't think p erso n a lly that the public relation s approach is now the answer to the sp ecific problem of our industry. 1 think that it is going to bo better to spend m ore m oney on environm ental controls of the d u sts, with strong em phasis on housekeeping, of the fum es, and of the g a s e s of which industry has "encountered. I feel that no m atter what the circum stances arc the problem s relative to the biological effects cannot be n eutralized or washed away by any types of r e le a se s or types of public program s. Industry m ust recognize that governm ental introduction into the field or into the workplace and the recognition of the hazards has been e s tablished. At this particular meeting there were several members of the labor m ovem ent th ere, and also m em bers o f the international AFWCXO which w ere a sso cia ted with D r. S ciikofi. It is apparent to m e that the next m ajor effort w ill be in the education of the w orkers. Xw as told by Dr. Selikoff and his a sso c ia te s in the labor field that we would have to begin educating the w orker in a m ore objective method and m anner. The w orkers would have to he knowledgeable concerning the absolute exposure at which they w ere subjected; they would be able to look at th ese counts to see the dust that they w ere exposed to, the length of tim e they w ere exposed, and according to the requirem ents of the OSHA act this inform ation m ust be provided to the w orkers. T here should be no allu sion that the company m ust initiate im m ediately the developm ent of an educational program principally organized by med ic a lly oriented people in a manner to pre cr.ly inform m anagement, forem en, and em ployees of the u ses, biological effects of asb estos, and what is being done to control this* a s c s e to s exposure. I say this prim arily because I have head recently in other industries that they have had h ysterical episodes among em ployees as to the instances of a sb esto sis in plants. This is created duo to p ress r e le a se s, public h y steria , and public p r e ssu r e . V/c w ill begin to se e a situation or a demand from the union and p ressu re from the public to do som ething about the situation. P lan s should be developed relating to im m ediate steps that should be taken as to the environm ental controls and to m ed ical prog%*ams. A com plete m edical program for the entire corpo ration is a Mml 'uI'Ms't. 1 think there is som e real hope though to reesta b lish the very cause of these carcinom as because it begins to appear that there ore som e other ca u ses a sso cia ted with asb esto s that precipitate th ese carcinom as and other changes that occur in ii.e eficc:*. of the n ebestos fiber. P erhaps, it is the fib er its e lf, p i reaps, it ia in .c..vc c ..soaintcu trace rr..-i.-.l that attaches it kcIX to the asb esto s fiber. A significant pape by Dr. J. C. McDonald stated that n. \..t >ak*e m eon. .*/: e ffects v*. a sb e sto sis ai'j t . ret:nogene si u if n. n nil .laud 1- --"l *. .*/ ii tib em . The a i%*,n>},i.-y of .; ..-vi*n 1 .. e.uitn- i-., p ri- aril'/ n*l. - : sir-..- ..* .... - j.t., ..lo -cm * m ic a l ;>ro* e r t ie s . i* .: huev*-..iir>}* t* *e u.at . a r a.i a iu s'in u n i eXidc ,>roc:-:c;* tl tumo:';:. in j -per pre: . t! by Dr. M. !*. Si-tnio.i, he sHiiivd *' 'if the ;u<r o' ; a j<*y .1 **cu.tin.* "b y ?-**1 |f * It*- * .*** '** I 5*"' **- t i t t i e d I i*i >i i i t i n I l i i J l i e . i . u o . . i* i J * l . ; m i . . i . i j , I t h e . . . . . tlto fiber id very iiii|irt.tiit .-i .nt u Ine j.rwductum *J t : rc< n**- genestn. A paper ny i)r . J . C. V/:o oner and Ci. i*>crry talked about the consideration of the logical u. :ci;.nti;."n* auu other factors that v.c-rc ft i. tbu.io the p an ictila r r.ixe of the .id- **and that . v y i . \ " * I.. : .1...- * o r to the tra ce e le m e n ts, but that th ere r.re indications that the fiber siz e and shape are important and that m esotheliom as have been produced with fib e r g la ss and other n o n -a s bentos m aterials* Jn intrapleural exp erim en ts a il types of a sb esto s used have produceel m esothcliom as in rats. A p er cen tage fig u re which you m ight u se a s a m easu re is 61% of an im als p ro duced ca n cer with c r o c id o litc , 36% with t m o site, 3*1% with aaatophyilite, -SCj^w ith Canadian c h r y so tile , and 19% w ith Rhodesian ch r y so tiic . A gifeat many of the people felt that the trace m etals w ere extrem ely r e le vant. The g rea test conclusion of a il v/ac that in em ploym ent in asbestos, especially the insulation v/orlter, smoking has a greater affect on ashes to sis and lung cancer than anything e lse , and every one of the asb estos w orkers should stop sm oking. There was great c r itic ism of Dr. Selikoff's paper by Dr. J. C. McDonald. He fe lt that the s ta tis tic s p resen ted in th is paper w ere not accu rate. He talked about the insulation w orkers and ho asked why the insulation workers that w ere not included in the union w ere r.ot p resen ted as a part of the study. I could go on for hours w ith variou s types of d ifficu lties and prob le m s they had with a sb e sto s, but one of the m ain things 1 would lik e to convey to you is that g la s s fib er is ca rcin o g en ic. With a peritoneal ir r i tation and the addition of beneopyrine with ch ry so tile a high rate of in c i dences of carcinom a w as produced. C hrysotile alone produced a very low incidence of m esotheliom a. In sum m ary, I would say that there arc many salient features to the d is c u ssio n s that w ere held at Lyon: (1) T here is ab solu tely a d irect conacc tion between ch rysotile a sb estos and m esotheliom a, broncogcnic c a r c i noma, and, of co u rse, a s b e s to s is . (2) The union rep resen tative w as adamant in that there w ill be a revolution in their particular area bring ing about the n e c e s s ity of industry getting ahead of the problem by in tro ducing an educational program that w ill orient the worker as to what he is exposed to. Of course, this m ust be done by m edically oriented per- . sonnel so that an aura of h y ste r ia is not crea ted . Thu fa cts arc to be presented in a logical sequence in a manner of im portance to such an extent that th ere w ili be a com p lete com pliance with ihe OSKA r e q u ir e m ents, and yet, not cause fear among em p loyees. It m ust show the com pany's in terest in the em ployees' health and what the company is doing to protect and safeguard their exposure. (3) There w ill be in crea sin g publications and p r e ss releasor, related to the significant "epidem ic" of m eso th elio m a and other typos of carcin om a o f the Ci. i. tract, pancreas, e tc ., ; ad then, anticipation of this particular rela tion sh ip should be com batted by educational orien tation ot the em p loyee. It should be em p h asized that the people v he are m ost at risk arc the w ork ers and they should be taught to use m a teria ls safely ana with con cern . (4) T here should be a com p lete ir.cdic&l program . A com plete su rv ey o f a ll the system s: including the pulm onary sy ste m by u.-e of m odern environm ental anti itu.du A u,uu.n; availab le to us and that-a regu lar rOUlinu education pv.r.im bo *t with this jMiyfiical cxaiui `d io e . A film cieip or a film nbuo'.ci be prepared for the ov icn - t'ttion o f tiu: `. a p b '/e c , e c p e c ie ll1/ sin ce ik illA v* gu lation s allow the individual to .*..k for bin expec.m e, too n;.iount o f expos.ore, and the dust to v/iie'i, *o h-*! Insert exjKosed, 1 Ihiuk *. t fhifl pn;*, inm v/il? brin:*, .-ibiul j,i*cule*` ;Me ri'Iniiniii. I ul i>e':tt-. dune, ;:* m .itter wli.'i! ,h - turns public relation e man wi l l prodre. . A pts'mc cducaticm pvo>.*r is certain ly in order in which one can, I telicvo, through the m edia of telev isio n , radio, and newspaper educate, the public as to the inreovutnee of a s b e s to s , its u s e s , the i>U;ojicai e ffe c ts o f as:i. jsiod, its co m . o. z' / < < and its indispcnsability to our modern technological society. It should be str e sse d that i i properly used .*Ad properly controlled, it is a perfectly safe product. I want to thank you very much for the opj ortunity to come in con- tact with som e o i the w orld's greatest scien tists and international exp erim en ters. I had the opportunity of liting next to the in ves tigator from M oscov/who invited m e to Moscow to visit his labora tory. I a lso had the opportunity o having long conversations and d iscu ssio n s with Dr. G ilson, Dr. Wagner, Dr. Webster, Dr. Gotin, and many others with international im portance and found m yself readily acceptable at their lev el. Of co-* ;r,e, there is a great deal m ore to be d iscu ssed about this subject, but I certainly don It think this is the place for it. There are volum es and volum es oi infor mation and letters that 1 have read and have with m e, and perhaps, at an opportunity that presents its e lf v/e w ill be able to d iscu ss it person to person. X send my best personal regards to you. . \ JLG /shl ; i 01382