Document 37ypQVKnKkOQ4KmeGL57M6Qrn

HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE dat e July 16, 1979 . TO; E. E. SWAIN, JR. FABRICS & FINISHES DEPARTMENT B-5254 . .. . TITLE* MEDICAL RESEARCH PROJECT MR-3540 PART I LEAD NAPHTKANATE AND LEAD TALLATE IN PAINT, SKIN ABSORPTION AND BLOOD LEAD LEVELS , JCA FAB JRG "d n h NF3 Authority is requested to undertake the investigation identified above and ' described as follows: Determine amount of lead absorbed (via skin) from paint containing 1.2% or 6.0% lead naphthanate or- 1.2% lead tailate. 1. Rabbits - 10 per group 2. Group A - controls, B-l.2% lead naphthanate in paint, C-6L% lead naphthanate in paint, D-l.2% lead tailate in paint. 3. Treat rabbits once/day, 5 days/week for 2 weeks.- Use 1 ml paint per treatment. Do not wash off. 4. Blood samples - day 0, day 5, day 10, and day 15. A preliminary study is required to determine whether anode stripping vo1tametry can be used instead of the dithizone method to measure blood lead concentrations. 5. Blood analysis - Chambers Works, Amount requested $8,000 Previously authorized Expended to date Account to be charged________ 1 lS\~ 1M - 14- Work to be started ASAP Request for study made by E. E. Swain and N. D. Krivanek 7-12-79 If this request meets with your approval, please -enter the account to be charged, have two copies authorized and return them to Haskell Laboratory, Control Section. The additional copies may be retained for your information and distribution. Proposed by N. D. Krivanek - Consultant Industrial Hygiene Approved by R,,.. J,. ' Geise -J Chief ustrial I fiene NDK/daw Date DUP040002333