Document 37kJ2vQnKEo8yxMzZdMV5LMEn

TRP S bodies G e n e ra l D e scrip tio n o f T e lo m e r M a n u fa c tu rin g P r o c e s s Radio-labeled Material Synthesis Description A cute O ral Toxicity - Fixed D o se Ranqe-Findinq Oral Toxicity - Repeated D o se Subchronic Toxicity - 90-day G a v a g e Study M o u se M icronucleus Test Bacterial R e v e rse Mutation (A m es) Test Pharm acokinetics: Pilot Experim ents (1 4 C ) P hy sico-C hem ical Properties of 8 -2 Telom er Alcohol: Ultraviolet / Visible A bsorption Spectrum , V ap o r Pressure, W ater Solubility, Sorption Properties Hydrolytic Stability Adsorption / Desorption: Soil, Sedim ent and Slud qe (1 4 C ) A e ro b ic Biodegradation (cold material, scre e n in g study, m ethod developm ent, standards preparation) - D u Pont study Aerobic Biodeqradation (14C ) A tm o sp h e ric D egrad ation / indirect P h o to lysis in A ir lo n q R anqe Transport Properties (Air /W ater) A cute Aquatic Toxicity Studies (Fish, Daphnia, Alqae) Microbial R espiration Inhibition T est Terrestrial Toxicity Studies (Earthworm , Nem atode, Plants) C hronic Toxicity (21-day Daphnia) C a n a d ia n R e s e a r c h P ro q ra m - Y e a r 1 Interim R e p o rt (M a b u ry et al.) P F O A Exop osu re A n a ly sis / Product & Article A n a ly sis AcuteTox G enTox Dev/Reprc PK X X X X X X EFE Other X X Docum ent overview overview final report sum m ary final report final report final report study plan (Date) Com m ents (March 03) Dec-01 DuPont subm ission (CBI) 15-Jan-03 (April 03) (April 03) 15-Jan-03 15-Jan-03 | P h y s-C h e m final report (March 03) X final report (March 03) X study protocol X final report 2 1 -M ar-03 DuPont subm ission (non-CBI) X study protocol X draft report (April 03) X study plan X final report 1 0 -M a rc h -0 3 X final report 1 0 -M a rc h -0 3 X draft reports (M arch 03) X study protocol X prog, report 2 1 -M ar-03 study plan 14-Feb-03