Document 34E1Br4yZgqZQjOnKpxLR9Rx

To: NCIC OPPT/DC/USEPAUS@EPA Suit AR225: Comments on Taker RessePian AR 226 _ 105 ft EP20A0-EaFsotnnBsuyillvdainniga AvReo,omM0414(61405M) rich purdy 07:33 me Bvoaxn = Jer 1 B11.i2o:c2h2eTnh.eThetes8t:2chiesmiqcuailc:klyWmheytatbhoeli8z:e2dtetolomPeFrOAal(cHoahgoeln oatndalm.otAntahle. 10:2 or tP1hF1a6OnA33i6n-3AR42326(.1981T)h)e, praenddicttheedremearteaboallirteeadyoflo10n:g2,terPFmDAt,oxiiscimteyrestutdoireisc on APnFeOrAse(nL, A Kinney, Fd Chen Tox 27 465-468 (1989);C T Olson and E T1o9x82)&. App Phar 78 p362-372(1983); C T Olsen, Dissertation Ohio State ToItxiccoalu.ses11a42d8e-c4r4e0ase(1i3n98)s)p.hinTghoimsyelmiany abendanPEOuNnsdhoaersednmotech(aCnhiems.m oRfes. Ztoorxictihteyse tuo chemicals. uncoupling As you are aware they both share the of oxidative phosphorylation mechanism of toxicity. dePpFuDrAatdoeeds (nAoRt22d6-e0p9u5r1a)t.e fTrhoims liisverproibnab2l8ydabyescauatseal"lPFwOhAilies excreted in the urine while PFDA is preferentially carricd mPoFrOeA risead1i0s0%y in the bilew haansd the property of being persistent in enterohepatic recirculation R(eCsh.em.Toxicol. 9, 689-695 (1996); Chem. Res. Toxicol. 5, 512-518 (1992)). bOneecaupsoessmiobrlee riesamsaodnetoandc/hoorosereltcoasteeds,t case. The concentrations in products b8u:t2 are tohvaetr dlooensgernothomaoplpoegasr mtioghbte about the same (RR226-1012, btehe o4f508Duzont, Daikin and Clarient). Their concentrations in air are within Ofrogladniocfseaacnhd Aotnhaelrysi(sJ WbyMaGarstinChrotomaaltogCroalplheyc/tCihoenmiocfalAirIboonrinzeatiFolnuoMraisnsated tShpeectdriofmfeetrreyn.ceAnianlvaCphoerm pinrespsruersses20o0f2)t.he Ttuhoistedliofmfeerrse:nce could be due to 32.0inHgydrtoolyhsyidsr:olyzWehyanpderfiogrnomrehydthreolyesstiesrssttuhdaiteswiolnl?an Maolsctohoplrodtuhcattsis not vceornytauisneifnugl thteo ktenloownetrhealrcaoteholosf btihinsd hthyedmrolvyisaisestfeorr pborneddsi.ctinIgt wtoheuldratbees wsothtoihrceahrgett,hhaenusaelQcSAoaRhnsdolsdtihsaatproessaorlme.elteiamsWeeesdhadivinestaognroteheewaceynovntisoriodenesmrteainbmtlaytefrftoomrhessperoomderuaccotefstuhnnedoewr parent substances containing telomer alcohols. 3l.eveTlissue levels: There appears to be no mention of determining the of the starting telorer alcohol or the perfluoro fatty acid metabolite tLiisvseures. It is very useful in performing risk assessment to have the baen.d sera levels of these at all dose lovels. The LOEL and NOEL can then ceoxmppraersesdedtointitsesrumes olfevetlisssufeounldeveiln. wilTdhelifteissauned hluemvaenlsNOtoEL/gLiOveELsancan be eGasttai.mation of risk. Many (Most?) toxicologists prefer this type of a4S.lrlobNoatbellayodmdeirtivperodtuocxtiscolaorgeyprstoubdaibelsy: addTihteivuel.timaItneadddeigtriaodnatitohneypracoeducts of 2 ------------ ee -- ---- -- Se ---- -------- ------ sahdoauiltdive with perfluoroalkylsulfonates. Therefore additive toxicity ibempoervtaalnutateids.sueBut this program, like the 34 program, ignores this