Document 30x3M6Y3d3ZGkbYxgKbw0ggn

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1951 Aug-Dec DOC#: API026 DOCUMENT DESCRIPTION: Letters, Memos, Reports, Financial Reports & Other Relevant Documents from Aug-Dec, 1951  tt*"* u,0IUT0.,r,oYti UNIVERSITY OF CINCINNATI DEPARTMENT OF PREVENTIVE MEDICINE AND INDUSTRIAL HEALTH August 1 5 a 1951 CABLE ADORESS: EETLAR. CINCINNATI TELEPHONE: CArlTOl 1414 jflj.. d . V. Stroop, Director Department of Technical Service American Petroleum Institute 50 West 50th Street Rev York City 20 Dear Mr* Stroop: For your information I am sending you herewith a statement of expenditures made on behalf of American Petroleum Institute during the second quarter of 1951* I believe that the statement will be self-explanatory, but if you have any questions or comments, Doctor Kehoe would appreciate your bringing them to his attention. Very truly yours, ef Enc. E. R. Fortlage', Secretary to D r . Kehoe > API 05118 . ' # UTP/ERSITY Or CINCimATI KETTERING LABORATORY ACCOURT OF AMERICAN PETROLEUM INSTITUTE For the Second Quarter 1951 (Based on Proporti of Time Actually Spent on Project) vjert A . Kehoe i 3ts Phair Lesley Horton Bussell Tye Hush P ie r le vrasik C le v e la n d Dutra Dorothy Tem pleton Vjarion D u v a ll jalp h Denham Carrie S iv e le y Karl Kraut le V&ld Younker It P e lta Raymond S u sk in d Supervision Coordination of Experimental Work Technical Assistance n it Pathological Assistance Pathological Assistance Tech11nical A1s1sistance n it it 11 n it n it n n 11 11 34.62 I375.O2 17 5 5 .00 1100.00 1200.00 219.48 24.02 363.45 336.11 I7 2 .5O 353.25 85.44 12.41 1 5 5 .9 1 25.08 iLLANEOUS E X P E N S E 7415.29 Traveling Expense Purchase of Animals 630.57 474.IO Laboratory S u p p l i e s ................................................ 2170.03 1 Proportion of Secretarial, Library, Janitors, Wash Boys, Draftsman, Shipping Clerks, Animal Caretakers, Histopathological Preparation e t c .................. 7331.36 Proportion of Heat, Gas, Electricity, Steam, Telephone, Postage, Pensions, Annuities, Maintenance, Animal Food and Supplies e t c ............................................... 3141.38 T O T A L ........................... 21,163.28 Balance Available for Further Work In 1951 at End of 1st Quarter 1 9 5 1 .......................... $39,470.86 j Expenditures - 2nd Quarter 1951 ........................ 21,163.23 3aiance Available for Further Work at End of 2nd Quarter 1951 ........................ 18 ,307.58 API 05119 August 17 1951 Br. B. B. Bm v ! Chains Medical Advisory Committee % Standard Oil Company (Indiana) 910 South Michigan Avenue Chicago 80, Illinois Dear Dr. Basest Ms hats boon Infnimsrt by Dr. xefaoe*s office that the unexpended balance of API funds at lettering Laboratory as of June 30, 1951 amounted to $18,307.58. This balance, plus the $50,000 payment nade as of July 1, 1951 glees then a total of $68,307.58 of the $100,000 budget for the 1951-52 fiscal year. The expenditures for the fiscal year 1950*51 amounted to $81,692.42. A copy of this letter is being sent to Dr. Msvqulst for his information. Very truly yours. DVSsrd ce - M. I. Msvqulst, M.D. D. T. Stroop API 05120 t A m erican P etroleum Institute 5 0 W E ST BOTH ST R E E T NEW YO R K 2 0 . N. Y. August 20, 1951 sobers and Associates ** subcommittee on Carcinogenicity gentlemen: This subcommittee is now in its seventh year and up to date approximately 000 has been expended on the API carcinogenicity project and an additional ^ 00^000 has been earmarked for the year ending June 30 1952. Dr. Kehoe's staff has done excellent work and the information obtained has been invaluable. However, it is conceivable that unless the program is reviewed in the light of the original objectives and needs of the petroleum industry, it might go on indefinitely at jjigh co6t and some of the information developed might not have much practical yalue to the industry. Therefore, I will appreciate receiving your recommendations on the spe cific questions in the attached questionnaire in order that the Subcommittee can collaborate more effectively with Kettering Laboratory as regards samples to be tested, development of an analytical technique and other phases of the project. Comments are also Invited from members and associates of the Medical Advisory Comnlttee who are not on this Subcommittee. For your information, I am attaching tables showing the number of animal tests and samples representing the processes and products selected by the Sub committee on February 1, 19^9 and the potencies of 50 samples or fractions there from. These figures are as of April 12, 1951 and undoubtedly, additional tests have been completed since then. I will appreciate receiving replies of all members and associates of the Medical Advisory Committee not later than September 17 1951. If the replies are widely divergent, it may be advisable to hold a meeting of the Subcommittee in Cincinnati about the second week in October. In such event, you will receive adequate notice. As you know, a report on the carcinogenicity project is to be given to the General Committee, Division of Refining, API, by Dr. Kehoe on November 6. It is quite possible that the General Committee will want to know about our future plans for studying and handling this subject so it is doubly important for the Medical Advisory Committee to have some definite recommendations from you. Very truly yours, M. N. Newquist, M a 5 T ^ Chairman, Subcommittee on Carcinogenicity MNN:GH Attach: ac: Members and Associates, Medical Advisory Comm. Dr. R. A. Kehoe API 05121 Table 1 - Number of saagles being tested on aalaals as of April 12, 1951. representing processes and products selected in 19^9 for study Number of sangles Number of tests THERMAL PROCESSES Charge 3 3 Recycle gas oil 1 l Fuel oil 2 2 Tar 12 13 VISCOSITY BREAKING Cycle gas oil 1 1 R e 8id 2 2 nap htha REFORMING Tar 3 3 COKING Charge Gas oil 1 1 1 1 Heavy gas oil 3 3 Blow down oil 1 1 Wax Tailings 1 1 GAS REVERSION (POLYFORMING) Tar 3 3 STEAM CRACKING 0 0 t CATALYTIC PROCESSES HOUDRY Heavy gas oil 6 6 THERMOFOR CATALYTIC CRACKING Cycle gas oil 1 1 Recycle gas oil 1 1 Synthetic bottoms 9 9 FLUID CATALYTIC CRACKING Gas oil 1 1 Heavy cycle gas oil 2 2 Bottoms (700/) from heavy cycle gas oil 1 2 Decanted oil 8 33 Slurry 2 2 HDUBRYFLOW 0 0 CYCLOVERSION Heavy gas oil 1 1 * Does not include animal tests for cocarcinogenicity, effects of washing, or "*tB on methylcholanthrene or dimethyl benzanthracene standards. API 05122 0XJROFOBMHJG Bottoms DESUUization (marginal case) - 2 Number of sables 2 0 cPfCUTC PRODUCTS --- rod waxes 0 slack WAXES Charge to press 1 Dewaxed oil 2 CERTAIN RAW LUBE STOCKS (UNTREATED) Naphthenic distillate 1 Gas oil 1 Resid 1 SOLVENT EXTRACTS Furfural 1 Phenol 2 Duosol 1 Nitrobenzene 1 Sulfur dioxide 1 ACID OILS FROM ACID SLUDGE Hydrolyzed acid sludge 1 White oil 1 PRODUCTS FROM OTHER INDUSTRIES COAL TAR 0 WATER GAS TAR 0 SHALE OIL - DOMESTIC AND BRITISH 0 82 Number of tests* d 0 1 2 1 1 1 1 2 1 1 1 1 1 0 0 0 " ~~ 109 * Does not include animal tests for cocarcinogenicity, effects of washing, or tests on methylcholanthrene or dimethyl benzanthracene standards. API 05123 * Table 2 - Potencies of oils (methylcholanthrene equivalents) High potency - above 0.1 Moderate potency - 0.02 - 0.1 Low potency - below 0.02 P o te n c y Description of Sangle 0.65 0 63 0^63 0.60 0.60 0.1+7 0.33 0.30 0.29 0.2h 0.22 0.22 0.20 0.20 0.20 0.l6 0.l6 0.16 O.lo 0.15 0.15 0.11+ 0.ll+ 0.11+ 0.11+ 0.11+ O .13 0.13 O.ll+N 0.12/ 0.11 0.12 0.10 FCC Slurry FCC Decanted oil FCC Decanted oil W 3632 FCC Press oil (85$) from decanted oil W3632 - FCC Desulfurized press oil from decanted oil W3632 FCC Aromatic fraction (from silica gel) of decanted Oil W3632 FCC Dewaxed fraction (MEK-benzol) of adecanted oil FCC Decanted oil TCC Synthetic bottoms TCC Gas oil - charge to thermalcracking Fuel blend from cracking TCC gas oil (Sample 29) TCC Synthetic bottoms Coking - Heavy gas oil Coking - Blow down oil Thermal - Tar from FCC Heavy gas oil FCC Heavy gas oil Houdry - Heavy gas oil Coking - Gas oil FCC - Bottoms 700 + from FCC heavy gas oil Cycloversion - Heavy gas oil Phenol extract, San Joaquin naphthenic distillate Houdry - Heavy gas oil Thermal - Tar from FCC gas oil Thermal - Tar from TCC gas oil Thermal - Tar from Houdry gas oil Thermal - Tar FCC - 50# Decanted oil W3632; 50# white oil ! W. Texas Resid. Thermal tar Thermal tar - feed contained cat. cracked components Thermal tar - 50# of above, 50# dodecyl benzene Houdry - heavy gas oil FCC Heavy gas oil API Sample Kuriber 26 12 8 8-3 21 8-5 1+3-1 1+2 31 29 3 10 33 53 2l+ 23 11 28 25 22 27 51 1+7 6l 35 61+ 8-1+ 55 20 20-1 50 1+6 O .09 0.08 0.08 0.08 0.07 0.07 Houdry heavy gas oil FCC - 50# bottoms 700 from FCC Heavy CGO, 50# white oil + W. Texas Resid. Coking - heavy gas oil Fuel blend - thermal cracking, feed cont'd cat cracked components FCC Decanted oil fraction 510-710, 1-platevac.dist. FCC Decanted oil fraction 1010 - IO650 , 1-plate vac. dist. 3l+ 25-1 52 39 12-1+ 12-5 API 05124 I O.06 O.o6 0 .o4 0 .0^ 0.03 0.03 0.03 - 2 Description of Sample Thermal tar, unflashed thermal resid. Polyformer tar Polyformer tar Naphtha reforming - tar PCC decanted oil asphalt from pentane FCC decanted oil, resid boiling 1065, TCC synthetic bottoms deasphalting 1-plate vac.dist. API Sample Number 6 37 13 19 12-1 12-6 9 0.015 0.01 FCC decanted oil, 2nd asphalt from pentane deasphalting 12-3 Phenol extract, Coastal 900X 16 0 Straight run gas oil 1 0 Straight run resid, Wilmington crude 5 API 05125 aUSSTIOKIIADS - SUBCOMMITTEE OK CARCUKXZNICITY August 20, 1951 g^ould animal teste be made on samples selected In 19^9 but as yet not tested; 1* specifisally those from desulfurization, s t e m cracking, rod waxes, coal tar, cmestic and British shale oil? 2 should additional samples representing any of the processes and products in the ' 1949 list be tested on animals? If so, which ones? Si * 3- Should the animal testing program be continued on its present scale for one more year or for two more years, by the selection of additional samples from various processes or should it taper off and be confined to the necessary prrifflftT tests in connection with the development of an analytical technique? i*. Should a large-scale animal testing program be initiated on fuel oils to de termine their potential hazards, if any, or should evaluation of these fuels await the development of an analytical technique? 5. Should efforts be directed toward development of a technique to eliminate the carcinogenic effect of an oil by removal or conversion of the carcinogens? Should the epidemiological study a. be continued for an indefinite period on an industry-wide basis, b. be maintained as a current registry of actual cases from petroleum products, or c. be limited to studies of a smaller number of refineries and other operations where medical departments exist and reliable medical data can be obtained? API 05126 X ^.tionsalr - 2- 6-20-51 sufficient information been developed to date in these studies to enable the ' uoivifl1ial companies to formulate adequate control measures 1 a. for their own employees, b! for their customers? . por how long should the total expenditures be continued at the present rate of $100,000 per year or should they be reduced to an amount sufficient to cover specific objectives only? 5. What other comments or recommendations do you have? Signed Company Date Please return to Dr. M. N. Nevquist, The Texas Company, 135 East 42nd Street, Hew York IT, N. Y. API 05127 r I > TH E TEXAS COMPANY 135 EAST 4 2 STREET NEW YORK 17, N.Y. Hr. D. V. S t r o o p American Petroleum Institute 50 West 5 0 t h S t r e e t He York, N e w Y o r k Dear Sir: I am attaching a letter, questionnaire and 2 tables should be mimeographed and sent to all members and associates of the Medical A d v i s o r y Committee. I w i l l a p p r e c i a t e it if y o u w i l l a r r a n g e to do t h i s as s o o n a s p o s s i b l e . P l e a s e s a n d one c o p y of the l e t t e r and tables and two copies of the q uestionnaire to e a c h p e r s o n so that they can send one copy to me and k e e p one f o r t h e i r files. which Very truly yours, MNNjGH ATTACH API 05128 -abers and Associate! TM o o m i t t e e on Carcinogenicity t!9& gentlemens This subcommittee is nov in its seventh year and up to date oproxinately $218,000 has been expended on the API carcinogenicity pr ject and an additional $100,000 has been earmarked for the year ending VP, 30, 1952. Dr. Kehoe'a staff has done excellent work and the infor mation obtained has been invaluable. However, it is conceivable that ,,oless the program is reviewed in the light of the original objectives gad needs of the petroleum industry, it slight go on Indefinitely at high eost and some of the information developed slight not have much practical ulus to the industry. Therefore, I will appreciate receiving your recommendations on the specific questions in the attached questionnaire in order that the the Subcommittee can collaborate more effectively with Kettering Laboratory as regards samples to be tested, development of an analytical technique and other phases of the project. Comments are also invited from members and associates of the Medical Advisory Committee who are not on this Subcommittee. For your information, I am attaching tables shoving the num ber of animal tests and samples representing the processes and products elected by the Subcommittee on February 1, 1949 and the potencies of 50 Maples or fractions therefrom. These figures are as of April 12, 1951 ud undoubtedly, additional tests have been completed since then* I will appreciate receiving replies of all members and ciates of the Medleal Advisory Committee not later than September 17, 1951. IT the replies are widely divergent, it may be advisable to hold a meet ing of the Subcommittee in Cincinnati about the second week In October, m such event, you will receive adequate notice. asso As you know, a report on the carcinogenicity project is to be given to the Oeneral Committee, Division of Refining, API, by Dr. Kehoe cn Bovember 6 . It is quite possible that the Oeneral Committee will want to know about our future plans for studying and handling this subject so it is doubly important for the Medical Advisory Committee to have some finite recommendations from you. .1 Table 1 - Number of samples being tested on animals as of April 12, 1951 representing p r o c e s s e s and products selected In 1949 for study Number of samples Number of tests* 7S lL C R A C K I N G Charge 3 3 Recycle gas oil 1 1 Fuel oil 2 2 Tar 12 13 VISCOSITY BREAKING Cycle gas oil 1 1 Res id 2 2 naphtha REFORMING Tar 3 3 COKING Charge Gas oil 1 1 1 1 Heavy gas oil 3 3 Blow down oil 1 1 Wax tailings 1 1 GAS REVERSION (POLYFORMING) Tar 3 3 STEAK CRACKING 0 0 ^.TALYTIC P R O C E S S E S h o u d &y Heavy gas oil 6 6 THERMOFOR CATALYTIC CRACKING Cycle gas oil 1 1 Recycle gas oil 1 1 Synthetic bottoms 9 9 FLUID CATALYTIC CRACKING Gas oil 1 1 Heavy cycle gas oil 2 2 Bottoms (700/) from heavy cycle gas oil 1 2 Decanted oil Slurry 8 33 2 2 API 05130 HOUDRYFLOW 0 0 CYCLOV ERSION Heavy gas oil 1 1 * Ijoes n o t inc l u d e a n i m a l tests f o r c o c a r c i n o g e n i ^ i t y , e f f e c t s of w a s h i n g , . r tests on methylcholanthrone or dimethyl benzatnracene standards. 0 jrtPROFCRMING " Bottoms ^gSULFURIZATIGN (marginal ease) Number of samples 2 0 r.TPTC P R O D U C T S WAXES 0 slack waxes Charge to press 1 Dewaxed oil 2 CERTAIN RAW LUBE STOCKS (UNTREATED) Naphthenic distillate 1 Gas oil 1 Resid 1 SOLVENT EXTRACTS Furfural 1 Phenol 2 Duosol 1 Nitrobenzene 1 Sulfur dioxide 1 ACID OILS PROM ACID SLUDGE Hydrolyzed acid sludge 1 'White o i l 1 PRODUCTS P R O M O T H E R I N D U S T R I E S COAL TAR 0 WATER GAS TAR 0 SHALE OIL - DOMESTIC AND BRITISH _0 82 - Number of tests* 2 0 0 1 2 1 1 1 1 2 1 1 1 1 1 0 0 __ 0 109 * Does n o t i n c l u d e a n i m a l t e s t s f o r e o e a r e i n o g e n i e i t y , e f f e c t s of w a s h i n g , or tests on m e t h y l c h o l a n t h r e n e o r d i m e t h y l b e n z a j h r a c e n e s t a n d a r d s . API 05131 I 1 ble 2 - Potencies of oils (methylcholanthrene equivalents^ '^-jetermined by animal tests reported as of April 12, 1951 . P^ ----*' High potency - above 0.1 Moderate potency - 0.02 - 0.1 Low potency - below 0.02 Description of Sample API Sample Number 0.65 0.65 0.65 r0 0.60 f 0.60 0.47 0.55 0.50 0.29 0.24 0.22 0.22 v 0*20 > 0.20 X 0.20 ' 0.16 0.16 0.16 yu 0.16 > 0.15 ? 0.15 0.14 0.14 0.14 0.14 0.14 0.15 .0.13 0.14\ 0.1 2 J o .ir 0.12 0.10 FCC Slurry FCC Decanted oil FCC Decanted oil W3632 FCC Press oil (85$) from decanted oil W3632 FCC Desulfurized press oil from decanted oil W3632 FCC Aromatic fraction (from silica gel) of decanted Oil W3632 FCC Dewaxed fraction (MEK-benzol) of a decanted oil FCC Decanted oil TCC Synthetic bottoms TCC Gas oil - charge to thermal cracking Fuel blend from cracking TCC gas oil (Sample 29) TCC Synthetic bottoms Coking - Heavy gas oil Coking -Blow down oil Thermal - Tar from FCC Heavy gas oil FCC Heavy gas oil Houdry - Heavy gas oil Coking - Gas oil FCC - Bottoms 700/ from FCC heavy gas oil Cycloversion - Heavy gas oil Phenol extract, San Joaquin naphthenic distillate Houdry - Heavy gas oil Thermal - Tar from FCC gas oil Thermal - Tar from TCC gas oil Thermal - Tar from Houdry gas oil Thermal - Tar FCC - 50$ Decanted oil W3632; 50$ white oil / W.Texas Resld. Thermal tar Thermal tar - feed contained cat. cracked components T h e r m a l t a r - 50% of above, Houdry - heavy gas oil FCC Heavy gas oil 50$ dodecyl benzene 26 12 3 8-3 21 S-5 43-1 42 31 29 30 10 33 53 24 23 11 28 25 22 27 51 47 61 35 64 8-4 55 20 20-1 50 46 0.09 0.08 v 0.08 ^ 0,08 0.07 0.07 Houdry heavy gas oil F C C - 50% b o t t o m s 7 0 0 f r o m F C C H e a v y CGO, 5 0 # w h i t e oil / W. Texas Resid. Coking - heavy gas oil F u e l b l e n d - t h e r m a l c r a c k i n g , f e e d c o n t 'd c a t c r a c k e d components FCC Decanted oil fraction 510-710, 1-plate vac.dist. FCC Decanted oil fraction 1010 - 1065, 1-plate vac. dlst. 34 25-1 52 39 12-4 12-5 API 05132 _ wo _ o.o6 0.04 0.04 0.03 0.03 0.03 Description of Sample API Sample Number Thermal tar, unflashed thermal resld. polyformer tar Polyformer tar Naphtha reforming - tar FCC decanted oil, asphalt from pentane FCC decanted oil, resld boiling 1065, TCC synthetic bottoms 6 37 13 19 deasphalting 12-1 1 -plate vac.dist.12-6 9 0.013 ^0>*01 FCC decanted oil, 2nd asphalt from pentane deasphalting 12-3 Phenol extract, Coastal 900X 16 0 Straight run gas oil 1 0 Straight run resld, Wilmington crude 5 I API 05133 > UESTIQNNAIRE - SUBCOMMITTEE ON CARCINOGENICITY A u g u s t 2ITc, 1 9 5 1 ould animal tests be m a d e on samples selected In 1949 but as yet not ^stedj specifically those from desulfurization, steam cracking, rod eSf coal tar, w a t e r gas tar, d o m e s t i c a n d B r i t i s h s h a l e o il? should additional samples representing a n y of the processes and products the 1949 list be tested on animals? If so, which ones? Should the a n i m a l t e s t i n g p r o g r a m be c o n t i n u e d o n its p r e s e n t scale fo r one m o r e y e a r o r f o r t w o m o r e years, b y the s e l e c t i o n of a d d i t i o n a l s a m ples f r o m v a r i o u s p r o c e s s e s o r s h o u l d it t a p e r off a n d b e c o n f i n e d to the n e c e s s a r y a n i m a l t e s t s i n c o n n e c t i o n w i t h the d e v e l o p m e n t of a n a n a lytical t echnique? Should a l a r g e - s c a l e a n i m a l t e s t i n g p r o g r a m be i n i t i a t e d on f u e l oils to d e t e r m i n e t h e i r p o t e n t i a l h a z a r d s , if any, or s h o u l d e v a l u a t i o n of these f u e l s a w a i t the d e v e l o p m e n t of a n a n a l y t i c a l t e c h n i q u e ? Should e f forts b e d i r e c t e d the c a r c i n o g e n i c e f f e c t of gens? toward an oil development of a technique to eliminate b y removal or c o n v e r s i o n of the c a r c i n o Should the e p i d e m i o l o g i c a l s t u d y a. b e c o n t i n u e d f o r an i n d e f i n i t e p e r i o d on a n i n d u s t r y - w i d e b a s i s , b. b e m a i n t a i n e d as a c u r r e n t r e g i s t r y of a c t u a l c a s e s f r o m p e t r o l e u m products, or c. b e l i m i t e d to s t u d i e s of a s m a l l e r n u m b e r of r e f i n e r i e s an d o t h e r operations where medical departments exist and reliable medical data can be obtained? API 05134 jt.j.onnair > 5^ - 2- 8- i r - 5i as s u f f i c i e n t i n f o r m a t i o n b e e n enable the i n d i v i d u a l c o m p a n i e s a, f o r t h e i r own e m p l o y e s , b. f o r t h e i r c u s t o m e r s ? developed to to formulate date in these studies to adequate control measures . for h o w l ong s h o u l d the t o t a l e x p e n d i t u r e s b e c o n t i n u e d at t h e p r e s e n t rate of $100,000 p e r y e a r o r s h o u l d t h e y b e r e d u c e d to a n a m o u n t s u f f i cient to c o v e r s p e c i f i c o b j e c t i v e s o n l y ? :t What other c o m m e n t s or r e c o m m e n d a t i o n s d o y o u h a v e ? Mimed Company^ Date ;.ease r e t u r n to Dr. M. N. N e w q u i s t , The T e x a s C o m p a n y , 1 3 5 E a s t 4 2 n d S t r e e t , York 17, N.Y. API 05135 Saptoabor 2k, 1951 Sr . M. I . laaqnlat Tha Tszxjb CoMsaaar 135 bit *2ad Stroat Ia* York 17/ ** York Daar Doctor Vavqulati Yte aaeloaad lattar, tetad Aagoat 2k, froa Y. J. Suda haa fcaaa fovnd la agr daak fila. It akoold tero toan sont to yo* a aooth go. Imrj t m l y groara, DYB:c Incloaur* API 05136 M m NEWOUIST. m .d n MEDiCA_ d ir e c t o r TH E TEXAS COMPANY 135 E A S T 4 2 " S T R E E T N EW Y O R K 17. N . Y. September 13, 1951 Mr- v - Stroop Aicerican Petroleum Institute 50 West 50th Street New York 2 0 , N. Y. D e a r Mr. Stroop: As mentioned in your letter of September 1 1 , 1951, a meet ing of the Subcommittee on Carcinogenicity will be held on Friday afternoon, November 2nd, 2 :0 0 to 6 :0 0 P.M. The question as to budgetary requirements again confronts us. Since the Medical Advisory Committee meets prior to the A.P.I. meeting, will that give you sufficient time to develop the necessary budgetary data, or do you wish us to supply this information within the near future? If our recent questionnaire on the scope of future research on carcinogenicity indicates continuance of our present studies in the same magnitude for the year 1952-53, our financial requirements will then be approximately the same as for the current year. All of the questionnaires have not yet been returned. Very truly yours, MNN:RMS cc : Dr B. API 05137 135 East 42nd Street New Yorx 1 7 , N.Y. October 17 , 1951 suitors and Associates * subcommittee on Carcinogenicity I am enclosing a summary of the naire which was sent to you on August 2 0 , answers were received from all 13 members ciate members, In addition, replies were members and 10 of 18 associate members of mittee at large. The 39 replies are from 39 replies to the question Of the Subcommittee, and from 8 of 12 asso received from 8 of 15 the Medical Advisory Com members and associates from practically all cf the companies represented on the Medical Advisory Committee, While the individual replies varied somewhat, it was pos sible to group them essentially as shown in the summary on the next two pages, A more detailed tabulation of the replies to each ques tion is also enclosed. You will no doubt wish to review this summary prior to the Uovember meeting. It, together with any further suggestions you may have, should provide a good basis for the Committee to collaborate effectively in shaping plans for future work on the carcinogenicity project at Kettering Laboratory, Thanking you for your cooperation, I am Very truly yours, M. N. Newql^, M.D. Chairman, Subcommittee on Carcinogenicity Attach. me. Members and associates, Medical Advisory Committee Dr, R, A. Kehoe Mr. D, V. Stroop API 05138 SUMMARY OF REPLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOC-ENICITY Shou l d animal tests be made on samples selected in 1949 but as yet not tested; specifically those from desulfurization, steam crack ing, rod waxes, coal tar, domestic and British shale oil? No 10 Yes 14 Certain ones only 13 Should additional samples representing any of the processes and products in the 1949 list be tasted on animals? If so, which ones? No 21 Yes 5 Some 3 Other processes and products 6 No answer 2 Shoald the animal testing program be continued on its present scale for one mere year or for two more years, by the selection of addi tional samples from various processes or should it taper off and be confined to the necessary animal tests in connection with the de velopment of an analytical technique? Taper off on animal tests and expand on analyt.tech. 26 Continue at present scale 7 As decided by Committee 3 No answer 1 Should a large-scale animal testing program be initiated on fuel oils to determine their potential hazards, if any, or should eval uation of these fuels await the development of an analytical technique? Await analytical technique 28 Initiate animal testing program 8 No answer 1 Should efforts be directed toward development of a technique to eliminate the carcinogenic effect of an oil by removal or conver sion of the carcinogens? No Yes No answer 28 6 API 05139 3 Susaary of Replies - 2- Should * a. b. c. the epidemiological study be continued for an indefinite period on an industry-wide basis, be maintained as a current registry of actual cases from petroleum products, or _ be limited to studies of a smaller number of refineries and other operations where medical departments exist and re liable medical data can be obtained? a 5 b 16 c 25 None 1 Revise present procedure 2 Opinion deferred 2 No answer 2 Has sufficient information been developed to date in these studies to enable the individual companies to formulate adequate control measures a. for their own employees, b. for their customers? Employe s Customers No answer Yes 19 Yes 6 3 No 15 No 28 For how I o n ; should the total expenditures be continued at the present rate of $100,000 per year or should they be reduced to an amount sufficient to cover specific objectives only? Reduce for specific objectives 26 Continue at present rate 10 No answer 1 '.'/hat other comments or recommendations do you have? See attached exhibit API 05140 \ REPLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY ^gSTIQO, 5^0 'Id animal tests be made on samples selected in 1949 but as yet not tested; specifically those from desulfurization, steam cracking, rod ,n-axes, coal tar, domestic and British shale oil? SUB-COM. M A No 2 2 No - if analytical technique is sufficient Yes 4 Yes - newly collected samples, domes tic materials before Brit. Ye s - limited number 1 1 Yes - rod waxes only 1 Yes - rod waxes, coal tar, Eriti sh shale oil only 1 2 Yes - rod waxes, coal tar, crudes only 2 1 Yes - shale oil only 1 1 NON-COMM. M A 2 4 1 1 2 2 1 1 1 1 2 TOTAL 10 2 8 2 2 2 3 3 5 SUMMARY No 10 Yes 14 Certain ones only 13 API 05141 REPLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY 0S?M_2 Hould additional samples representing any of the processes and pro *ucts in the 1949 list be tested on animals? If so, which ones? ?To 1-io, probably SUB M 53 1 yot too important 1 yo - if analytical technique is sufficient Yes 1 1 Yes, probably 1 Yes - only in connection with analytical technique 2 Yes - high potency products only Yes - some, based on Dr. Ilehoe's advice 1 Yes - rod waxes Yes - asphalts, lube oils, aromatic solvents, cutting oils and other products where exposure factor is high 2 1 Yes - sulfur dioxide extract cils from cat.gas oils; methyl naphthalene, heavy nitrogen cyc lic cpds., heavy virgin gas oils; HP acid soluble oils; heavy oils from dehydrogenation of butane and butylene ITo answer SUMMARY No 21 Yes 5 Some 3 Other processes and products 6 No answer 2 a o >g NONCOMM. M A 3 6 1 1 1 1 1 TOTAL 17 1 1 2 2 1 2 2 1 1 3 1 1 2 1 1 2 API 05142 \ rt?LIS TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY - aid the animal testing program be continued on its present scale one more year or for two more years, by the selection of addition- saJnpl9s from various processes or should it taper off and be con * ned* to the necessary animal tests in connection with the development an analytical technique? SUB-COMM. M A Taper off on animal tests ar.d expand analytical technique 4 1 Restrict new samples and complete analytical technique 1 4 Restrict and complete analy tical technique, study fuel oils 1 Analytical technique only, if limited to one choice 1 Continue for 2 years at least 1 Should be continued for many years 1 Continue especially for ana lytical technique 1 1 Continue at such scale as de cided by Medical Advisory Committee 2 1 No answer NON-COMM. M A 4 8 3 2 1 TOTAL 17 5 1 1 6 1 2 3 1 SUMMARY Taper off on animal tests 26 and expand on analytical t3chnique Continue at present scale 7 As decided by Committee 3 No answer 1 API 05143 REPLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY uld a laree-scale animal testing program be initiated on fuel oils determine tbeir potential hazards, if any, or should evaluation of these fuels await the development of an analytical technique? SUB-COMM. M A Await development of ana lytical technique 3 1 Await analytical technique - include 1S20-1940 fuels with out catalytically cracked fractions 2 Check analytical technique by animal tests 2 No animal testing for fuel oils 2 2 No need to concentrate on residual fuel oils 2 1 Review animal testing pro gram before starting Yes for animal testing 1 1 Yes, for animal testing on a limited scale for typical types of operations 1 1 Yes, after present project is completed or shows more posi tive results No answer SUMI'iAHY Await analytical technique 28 Initiate animal testing program 8 !.o answer 1 NON-COMM M A 3 5 1 1 1 1 3 1 1 1 TOTAL 12 2 3 4 3 2 2 6 2 1 API 05144 REPLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY -hould efforts be directed toward development of a technique to ali enate the carcinogenic effect of an oil by removal or conversion of ge carcinogens? SUB COMM. M A No 2 3 No - O.K. though in connec tion with the study of pure carcinogens 3 2 No - but determine the car cinogen 1 Premature - probably not a Med. Adv. Comm, function 2 2 Yes 2 Yes - preliminary efforts only 1 Yes - for consumer protection 1 Indefinite - conversion would be safer than removing carcino sens No answer NON-COMM. M A 3 8 1 1 2 1 1 1 TOTAL 16 5 1 6 4 1 1 2 1 SUMMARY NO 28 Yes 6 No answer 3 ApI 05145 REPLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY .tr^ l C N 6 Should the epidemiological study a# be continued for an indefinite period on an industry-wide basis, b * be maintained as a current registry of actual cases from pet ' roleum products, or c, be limited to studies of a smaller number cf refineries and w* other operations where medical departments exist and reliable medical data can be obtained? b and c only SUB-COMM. M A 5 2 b or c a only 1 2 a if possible 1 c only 2 1 Modify present survey and then maxe an epidemiological study 1 1 Obtain Dr. phairs opinion 1 1 No epidemiological study 1 No answer NON-COMM. M A 2 3 1 3 1 3 3 1 1 TOT. 12 4 4 1 9 2 2 1 2 31L,IIARY a 5 b 16 c 25 None 1 Revise present procedure 2 Opinion deferred 2 No answer 2 API 05146 REPLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY ^rgSTlON-Z eoc sufficient information been developed to date in these studies to 5 ble the individual companies to formulate adequate control measures 3 a, for their own employes, b. for their customers? SUB- COMM. M A NON- COMM. M A TOT. Employes, yes - customers, yes Employes, yes - customers, no Employes yes - customers, yes (tentatively) Employes, no - customers, questionable Employes, no - customers, no Cannot answer intelligently No answer SUMMARY Employes Yes Customers Yes No answer 3 5 2 1 2 5 3 1 19 6 22 4 2 4 13 1 2 1 3 22 12 1 1 1 2 No ' 15 No 28 API 05147 REFLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY voT :iov. long should the total expenditures be continued at the present l ate of $100,000 per year or should they be reduced to an amount suf f i c i e n t to cover specific objectives only? For specific objectives only SUB COMM. M A 3 3 Should taper off soon 1 At such scale as decided necessary by Med.Adv.Comm. 2 3 Continue for one year and then review Continue for at least 2 years 1 1 Continue as at present 1 Contine at present rate but alter line of emphasis 1 1 Continue until completed, even if hieher cost 2 No answer NON-COMM. - Ivl A 6 3 1 1 1 1 TOTAL 20 1 5 1 A *X 1 2 2 1 SUMMARY Reduce for specific objectives 26 Continue at present rate 10 No answer 1 API 05148 REPLIES TO QUESTIONNAIRE - SUBCOMMITTEE ON CARCINOGENICITY 9 -liflt other comments or recommendations do you have? S U B COMM. M A Study protective creams 7 4 Study protective creams and washing 3 1 Study protective clothing and devices 4 1 Study cleansing agents NON-COMM. M A 2 1 Inhalation studies of potent oils as possible pulmonary carcinogens 3 2 1 Evaluate hazard to humans (using monkeys) of oil vapors alone 1 1 TOTAL 13 4 5 1 6 2 Animal tests with and without washing but stopping applica tion when first tumor appears 1 1 Develop a non-biological test 1 1 Continue or expand work on iso lation of pure carcinogens 1 1 Test monkeys or dogs to get hotter human correlation' 1 Translate animal test results to humans 1 2 2 2 1 1 API 05149 develop information on what constitutes hazard with re- snect to concentration and length of exposure 1 Develop reasonable potency factor applicable to normal working conditions Discuss matter of consumer risk Develop information to com pare properties of cat. and thermal oils which are potent to mice with slack waxes and soinning oils where human ex posures are known 1 Study marketed products 1 Study lube oils (insoluble cutting oils) where exposure factor is hish 1 1 Study soot from chimneys where oil and coal are used as fuel 1 Study sinale ring aromatics or 2-condensea ring aromatics to see if they act similarly to dodecyl benzene 2 Study cocarcinogenic effect of ultra-violet radiation Continue sufficient studies to maintain a continuing reassur ance that present conclusions are sound Gather all possible information for possible future medico-legal use ` Collaborate with General Comm on Refining in the definition of future work 1 NON-CO hl,I M A 1 3 1 1 r\ TOTAL T 4 2 1 1 rt>j 2 1 2 2 1 1 12 3 1 1 2 API 05150 1 Heplies to Questionnaire Question S -3- SU3-C0MM. I.i A NON-COM!.'. MA Express commendation for excellent work done 1 1 Prefers to defer opinion un til November meeting 2 API 05151 API 05152 L& H P r in t in g Compaq API 05153 P (5 -i2 .T *o + V ` B iw n **- w c - w o v , ; h $- >v- UN IVERSITY O F CINCINNATI COLLEGE OF MEDICINE CINCINNATI IB. OHIO OF AFFLISI) FHTSIQLOOr Hovember 5 19SI I-AJI W ADOUBEE* I B T U I . CINCINNATI TELEPHONE) UHITEEEITT I M I Mr. D.V. Stroop, Director Technical Service Division American Petrolotot Institute 50 Vest 50th Stroot Mow York 20, lev York Dear Mr. Stroop* During the meeting last Priday of the Subcommittee on Carcinogenicity ve diecueeed a tentative lineup of assoelate members for the proposed Steering Comalttee. Since later developments seemed to have limited the sise of the committee to four medical members and four technical assoc iates, some revision of our tentative suggestions is perhaps in order. Since there are important differences in the interests of companies in different parte of the country in any par ticular phase of this investigation, it would seem most desirable that the technical half of the Steering Committee bring together men from each of the four major refining areas: last Coast, Midwest, Southwest, and California. It would further seem that in view of the small else of the proposed group no two voting members should represent the same company or its affiliates. In the technological and analytical aspeots of this project we have enjoyed the active cooperation of the tech nical staffs of over 90 per cent of the companies repre sented on the Medical Advisory Committee. Bence, in ten tatively suggesting the following group of technical men for membership on the Steering Committee we are in no way inferring a lack of interest or cooperation on the part of other companies but rather aiming at the bringing together of a group representative of the widely varying interests of different segments of the petroleum industry. Bast Coast Midwest Southwest California R. D. Bent B. V. Adams C. A. Meilson R. C. Mithoff API 05154 Mr* D. V. Stroop - 2- November 5, 1951 The suggestion that Mr. Bent represent the East Coast refiners reflects our feeling that his approach and that of his company to this problem represent best a compromise between the widely divergent and competitive viewpoints of the groups who make New York their headquarters. Since the medical group must almost of necessity include representatives of the Texas Company and Jersey, the New Yorkers should not feel neglected. We would again urge that the medical half of the Steering Committee include representation from the South western and California oil companies. Our vote here for Dr. Kieffer Davis requires no explanation. Dr. L. E. Curtis has already put in a rather strong vote for Dr. J.C. Ruddock for the medical representative for the California group. We can add to that bur observation that the cooperation of the Richfield group, through Mr. C. R. McKay, has been tops. In view of the very Important role this Steering Com mittee will have, we very much hope,that through your good offices as moderator,the various competitive groups in New York will have no reason to feel dissatisfied with its lineup. Our suggestions above are only very tentative in character. We shall make every effort to cooperate effectively with whatever group the Medical Advisory Committee chooses to represent it. I appreciated very much your frank advice concerning the feelings of some members of the committee. Sincerely yours, I AWH:mjg pJ\ A. Wesley Horton >> API 05155 TH p h k s id b n t A m erican P etroleum Institute 9 0 W E ST SOTH S T R E E T NEW YORK 20. N. Y. November 16, 1951 T Members and Associates T Medical Advisory Committee gentlemen: Dr. M. N. Newquist, Chairman of the Subcommittee on Carclno- enicity, has appointed the following persons to serve on the Research S Reject Advisory Committee to collaborate with Dr. Kehoe and his staff concerning the A.P.I. project on carcinogenicity: M. N. Newquist, M.D. E. W. Adams L. C. Beard, Jr. Kieffer Davis, M.D. R. E. Eckardt, M.D. T. M. Prank, M.D. Chairman C. H. Hine, M.D. R. M. Landon E. K. Linder, M.! K. Q. Mackenzie R. C. Mithofi R. M. Shepardson The RPA Committee has been made large enough to insure continuity of its work by an adequate working attendance and repre sentation at its meetings. The RPA Committee does not replace the Subcommittee on Carcinogenicity. A meeting of the RPA Committee will be held at the Kettering Laboratory in Cincinnati, Monday, November 26th commencing at 10:00 A.M. and continuing through Tuesday forenoon, November 27th, if neces sary. Dr. Kehoe has tentatively reserved eight rooms at the Terrace Plaza Hotel. Committee members attending should notify the hotel at once as to time of arrival, indicating that the reservation had been made tentatively by Dr. Kehoe. Also notify Dr. Newquist whether or not you will attend the meeting. Very truly yours, D. V. Stroop API 05156 NEWOUIST. M.D. M N medicai,director TH E TEXAS COMPANY 135 EA ST -42"? ST R E E T NEW Y O RK 17, N.Y. November 16, 1951 Mr. D. V. Stroop American Petroleum Institute 50 West 50th Street N e w York, N. Y. Dear Mr. Stroop: I If the attached letter concerning the Research Project Advisory Committee meets with your approval, will you kindly have it mimeographed and send out at once. Very truly yours, 4 MNN :RMS ENC. M. N. NEWQUIST, API 05157 November 19, 1951 Dr. M. I. Nevquisft, Tha Texas Company, 135 East 1.2nd Street, Hev Xoric 17, lev Tork. Dear Dr. Nevqaist: Kindly refer to Hr. Stroop*a letter of loeeaber 16, 1951, in regard to the Eesearch Project Idriaory Conaittee nesting on loraaber 26*27 at Cincinnati. I expect to be aaong those present. With best regards, Very tru ly yours, RXL/rJ cc: Mr. D. 7. Stroop API 05158 November 20, 1951 To M e m b e r s of the R.P.A. Consaittee of Subcommittee on Carcinogenicity Gentlemenj I am attaching for your Information an outline of proposed studies as contained in tbs Kettering Labora tory report of September 2$, 1951* and also a portion of the minutes of the Medical Advisory Oewittee meeting pertaining to the report of the Subcommittee an Csroinogsnlcity. The attached data may be of assistance to you by p o i n t i n g out some of the subjeots f o r dissuasion at the meeting a t K e t t e r i n g L a b o r a t o r y N o v e m b e r 26th. W e h o p e to expedite the d i s c u s s i o n so that ve will be aole to c o n c l u d e the b u s i n e s s at hand in one day, if possible. Very truly yours, 1 I M. N. l E U M J I S T y - ^ D . s. Adams L. C. Beard, Jr Kieffer Devis, 3.D R. E. Eekardt, M.D T . M. Frank, M.. C. H-. illne, M.D. R. M. Landon S. K. Linder, M.D. K. 0 * Mackenzie R. C. Kithoff R. *'mie Shepardson S. B. Reeve, M^D. D. V. Stroop */ for information API 05159 PROPOSED ST3DI35 AS LISTED 18 CSTT2R2XO LA3QRA? rrr r e p o p t : s s t t s m b b i 8ft. isi iffacta of ooaarolnogana - acre thorough inveaticatlon of hydrooarboo typaa In 500 - 700 ? boiling rang (p. 3, 12, 13, 25 and 30) * .8tab11ah a aufficlent voluaa of blologloal and phya loo-oha^alcal '* data on thana 11y-oraoitad aidaatraam to expedite developaent j;- an analytical technique for thasa aIdatreeae (p. 4 and 23) J( Sroad survey of luba dlatlllataa - initially by apootrophotoaatry and latar oonflunation of unua jal poteaoles by aoaaa tasting (p. 4 and 15) 4 , larger voluaa of biological data on residue frua Unarm .1 creating of virgin faada - to correlate apetrophotonetrio oharaotaristloa with aarolaoganla potaaoiaa (p* 5 and 25) 5, Consider a study of oraokad tart froa oatalytia raforsiing {p. 15) 4. continue atudy of bland of raflnary intermediates, t.:o aoat Important of tbaaa produets bolng induatrial fual oila and road oila (analytical phaaaa auat await reacts of biological taata (p. 15 and 25) 7. Continue atudy of a paneagad luba oil and aa oil of 10<V V. I. (?. 19) 8 Continue atudy on aethyloholan throne reforanoe atandarda (p* 19) 5. Studioa to develop a rapid teat to datamlna whether a Ivan hydrooarbon aolvaat ia aaroiaoganio (p20) 10. Continue weaning axpariaanta (p. 20) 11. Continue protaotivo araaa axperiaenta (p. 21} 12. ^hexlcal aynthaala to aatabliah identity of the soti'e osrclno- gana ia oila (p. 50) 13. -tody affwata af eooareisogena in conntIon with air oxidation taata (p. 31) API 05160 2- j. T hat i t b# a s c e r t a in e d w h e th e r o r n o t g r o u p ! o f tw enty m ice are s t a t i s t i c a l l y adequate f o r b io lo g ic a l te s tin g in th is p r o Je o t. S. That potency fig u re s be expressed sep a ra tely fo r papillom as and m a lig n a n c ie s . 9. T h a t d e t a i l e d d a ta s h e e ts on a l l com p leted e x p e rim e n ts be in clu d e d as a p a r t o f a l l p ro g re ss r e p o r ts from K ettering Laboratory. . 10. T h at the in te r im r e p o r t , d a te d Septem ber 25 1951 be not transm itted to In s tit u te o f Petroleum , London, u n t il a fte r c o lla b o r a tio n o f the R esearch P r o je c t A dvisory Committee w ith D r. Kehoe, in order to allo w fo r in c lu s io n in the t e x t of more r e e e n t f i n d i n g s and c o n c lu s io n s i n c o n n e c tio n with current s tu d ie s . 11. That the e p id e m io lo g ic a l su rvey work be co n tin u e d on i t s i p resen t b a s is fo r the time b e in g . ACTION F o llo w in g an extend ed and d e t a ile d d is c u s s io n o f the r e p o r t , the Com m ittee v o te d to a c ce p t the f i r s t , seco n d , end e le v e n th recommendstione but to r e fe r the other e ig h t recommendstione baok to the Subcommittee fo r assignm ent to lt e R esearch P r o je c t A d visory Committee fo r an e a rly con feren ce w ith p r o je c t d ir e c to r s in the fo rm u la tio n s o f s m u tu ally so o e p ta b ls 1952 program o f w ork. API 05161 MEMORANDI^ FROM TEE KETTERING LABORATORY ON FURTHER PROSECUTION OF API RESEARCH PROJECT MC-1 qeope of Project In February, 19U9> the Medical Advisory Committee recom mended that materials from the following processes be studied: NON-CATALYTIC CRACKING Cracking of catalytic gas oil Cracking of virgin gas oil Viscosity breaking of residues or extracts Naphtha reforming Coking Gas reversion and polyforming Steam cracking CATALYTIC CRACKING Houdry T. C, C. F# C C Houdryflow Cycloversion Hydroforming Desulfurization (marginal case) PRODUCTION AND LU3E REFINING Rod waxes Slack waxes and press oils Certain raw lube stocks (untreated) Solvent extracts (furfural, phenol, sulfurdioxide) Acid oils from acid sludge (marginal case) PRODUCTS FROM OTHER INDUSTRIES Coal tar Water gas Shale oil tar - domestic and British sources. In line with the interests of this committee and further recommendations expressed at the regular meetings, the following r e l a t e d p h a s e s of the problem have been given careful attention by the i n v e s t i g a t i v e group: API 05162 - 2- 1. A n a l y t i c a l te c h n i q u e s to es t i m a t e order of potency of any g i ^ n , / above. / stream from any or the processes listed 2 . Epidepiiological appraisal of the incidence of/cancer f / ` / / among employees o/the petroleum industry j4l* ii Jiygienic m e a s u r e to reduce haza r d to 9Sployee3 of the I! - petroleum^ihdustry. i, Dilutiop''of carcinogenic oils a s m e a n s of reducing / / p o ^ n t i a l hazards to e m p l o y e e ^ of industrial consumers ` s'ot various petroleum products containing these oils. Plans for Investigative Work for 1952 rvlL P^^cess Samples for Animal Tests, ** C ^ 1 ^ ` V/V#-2 S"''^' * -1* -Cracked residuC'Trom thermal cracking of virgin gas ,, c -- ------------ - ^ oils (samples to be collected). 2 . Sidestreams and residua from other cracking processes * to be tested on a limited basis to improve analytical methods of estimating potency and further to test the validity of these methods (these samples already col lected, analyzed spectrophotometrically, and held in reserve in the laboratories of twenty-one of the par ticipating companies ), 3. Untreated lube stocks from straight run distillation f V now being screened by analytical methods. Samples to u be selected for animal testing on the basis of a com- \ t parison of their physical properties (including ab sorption spectra) with those of virgin distillates already tested. - 3 - i;, Scottish shale oil and fractions thereof. To gain further analogies between potencies to mice and potential hazards to exposed humans, two or three fractions of shale oil comparable to those employed as spindle lubricants in the British cotton industry to be tested. (Samples already collected and held at Kettering Laboratory);.. _ ^ ^ /U^ ^ * tr ; h B* * m ' / Reference Standards, w* 7 r ^ w ^ . . A .< , >-..V For control purposes and improvement of biological^-^.*^ :\ J ( ^ '* 7-'/-VV *f \ ' 3'J 'bfty methods it is contemplated that tests on known concen trations of standard carcinogens in standard solvents will be carried out with about 9 percent of the animals received. h* i vr A\ c Analytical Techniques for Estimating Carcinogenic Potencies of Petroleum Products. Chemical research will continue on the two main approaches to this goal, the empirical and the fundamental. Animal testing of fractions which can furnish useful information for this purpose will, as in the past, be given priority over tests on process samples. At the same time, it is recognized that an analytical tool has very limited sig nificance when based on an inadequate number of biological tests of samples of materials to which it is to be applied. V vc Tests on non-carcinogenic fractions of various oils will in o be conducted to determine the effects of variations in the a, composition of these fractions upon the total effective < potency of the oils. It is obvious that if fractions which do not contain polycyclic carcinogens are markedly affecting - k- the rate of induction of tumors in the test animals, then any tool based purely on the concentration of polycyclics will he seriously limited in general applicability. Epidemiological Studies. Efforts to expedite the collection of case records and other pertinent information on an industry-wide basis will be continued. At the present rate of reporting, there should be sufficient accumulation of information by the time of the spring meeting in 1952 to permit a preliminary tabulation of the data. E. Experimental Study of Efficacy of Various Cleansing Agents and Skin Creams. II As soon as the current tests which employ rinsing with white oil and washing with detergent solution have been completed, new experiments will be started to compare hydrocarbon solvents, such as technical white oil, with <1 the viscous medicinal white oil currently employed as a ~~~ rinsing material. Further tests with other skin creams will be designed n V\ on the basis of the results of the current tests with Verex. API 05165 F. Dilution of Carcinogenic Oils. Sixteen of the participating companies have already started or completed collection of representative production blends containing carcinogenic streams from catalytic cracking or recycle coking, together with data on the com position of these blends. The majority of the members of the committee have evidenced their desire for an analytical tool applicable to these complex mixtures. Since it is obvious that no such tool could be developed without knowing the biological potency of at least a few of the blends, a selected group of these materials, on wnich detailed information is available, should be suojected to a n i m a l testing. II API 05166 o o g o o *)0 O -tK> O 89TS0 IdV 'too lO'O }! O OI C-toi+fj 'if / * / A ' . ' f f ' / . t S ' r C y f ) , V r ^ \ `A .va' /Jj"* i/OOit'/ /a I I I . ; ! O O 2. o o3 a >t, OS' o 7 i .' API 05169 ' t. ' \N ) ) ) ~l ri i ! i i ) ) U r r r r tr Ui C R C a l if o r n ia esearch a s u b s i d i a r y or orporation 200 BUSH STREET SAN FRANCISCO A. CALIFORNIA November 30, 1951 PILE 084.171 3 T. M. H. Newquist The Texas Company X35 East 42nd Street Heir York 17, New York D ear Dr. Newquist: Beeause of absence fro ay offlee, Dave Stroop's letter of November 16, 1951, has Just ooe to my attention, in hleh be Informs s that I u appointed to seres as a ember of your API Research Project Advisory Coaalttee oa carcinogenicity. I shall be pleased to accept this appointment and shall endeavor to attend all future nestings and to take an active part In the work of the Ccanlttee. 1 regret that previous coonltaents prevented ay attending the first nesting of the Conalttee in Cincinnati on November 26. However, I assune that minutes of it will be circulated and that they will serve to bring me up to date. I look forward with great interest to attending the next meeting. Very truly youra, Ortoird Dr. L, E. Curtis API 05175 ~ YAx-- W - " * " V ^L S T T E 2 f3A-LLoV) ^y - / Members and Associates Subcommitte on Carcinogenicity ^ farXJi* ' I am enclosing a copy of the minutes of the meeting of the R e s e a r c h Project A d v i s o r y C o m m i t t e e w h i c h was h e l d at Kettering Laboratory, Cincinnati, Ohio, November 26, 1951. Will you k i n d l y indicate your approval or disapproval of the a c t i o n s an d d e c i s i o n s of the R.P.A. C o m m i t t e e on the e n c l o s e d letter ballot and return it to me. Negative votes should be accompanied by an explanation. I will ions you m a y Laboratory. also have appreciate receiving any cone e rning the research comments and suggest project at Kettering Very truly yours, MN:7:CH \ Enc. r M. N. N e w q u i s t , jfl.D., Cha i r m a n , Subcommittee on Carcinogenicity API 05176 r M edical LETTER BALLOT of the Subcommittee on Carcinogenicity, Advisory Committee, ^American Petroleum Institute Shall the actions and decisions of the Research project Advisory Committee as shown in the minutes of the November 26, 1S51 meeting at Kettering Laboratory, Cincinnati, Ohio, be approved by the Subcommittee: Yes No* Not voting < *It is requested that any n e g a t i v e vote be a c c o m p a n i e d b y an explanation. nr f r r o h Date API 05177 Yorwtbar 29, 1931 Sr. X. I. Banqalrfc Ebe Texas Company 133 last kSxA StrMt Bav lark 17, frv York Saar Doctor BOvqalat: Pursuant to year aucseatlon ttoara 1b eaclossd rrrlaad roach draft of tha slants of tha first at 1tot of Be-- arch ftrojeot 1C-1 Adrloory Comittea. lour approval aod oonroctlooa 111 to Tory troly year, DIBie Sooloaara API 05178 yam-JHBF-K- Report on First Meeting Research Project IC-l Advisory Canal ttae Roveabar 36, 1951 Kettering Laboratory Cincinnati, Ohio imfiZFS FQF9ENT M. X. Hewiulst - Chalrnan E. V. Adana L. C. Beard, Jr. Kieffar Paris ? S. Eckardt R. M. Shspardson T. N. Frank fi. M. Landon 3. K. Linder (Rep. by R. D. Bent) X. 0. Mackenzie mnmyRS ABSEHT AHD HOT C. 3. Hina R. C. Mlthnff QTffURS firSHfr F. y. Heyroth - Kettering Laboratory A. w. &rton - Kettering Laboratory Robert A. Kahoe - Kettering Laboratory John J. Phalr - Kettering Laboratory Lari4 v. Stroop - Anerican Petroleun Institute I PROGRAM OF PROJECT lC-1 In opening the neeting the cbalman ontllned the alas of the Medical Advisory Cassettes and stated that the Research Project Advisory Camlttee had been appointed to afford a closer bond of mdaretandlng between conalttee neebers and rssearch workers Those present handed eoples of a "Msaorandue frea Kettering Laboratory on Further Prosecution of API Research Project MC-1," dated vOl a-i-T'-- ' Koveoler 26, 1951, which was diseaseed,,ltea by lten aa follows! "A. Process Seaplss f** *<nl Testa API 05179 1. "Crooked residua fran X " g of virgin gas oils (aanplee to be collected)." Two samples of residua from thermal cracking operations at Evsrstt and Aruba rsfiasrise vert offerad '07 B. M. Sheperdaon aa products of thermal cracking operations which bare bssn used without significant change for nan7 Tsars. The advisory comittee voted to accept the offer of the two samples. 2 . "Sidestream and residua from other cracking processes to be tested on a limited basis to Improve analytical methods of estimating potency and further to teat the i validity cf these methods (these samples already 4 collected, analysed spectrophotonetrlcally, and held in reserv* In the laboratories of twenty-one of the participating companies)." In response to a question, it was explained that thee# samples were not fuel oil; they cosijrised a Halted number of existing samples requiring biological tests to round out data needed in the development of the analytical tool. T ACTION The recasnendatlon was accepted. 3 "Untreated lube stocks from straight run distillation now being screened by analytloal methods. Samples to be selected far animal testing on the basis of a comparison of their physical properties (including absorption spectra) with those of virgin distillates already tested." ACTICK In the understanding that these samples comprised those received from the British Medical Research Council, the coxsslttee voted for a prompt initiation of t and analytloal tests an the Oklahoma Bright Stock and Kuwait and Yen*ruela crude oils. API 05180 k. "Scottish shale oil sod (notions thereof. To gain further analogies between potencies to alee sad potential hazards to exposed huusns, two or three fractions of shale oil comparable to those employed as spindle luhrloants la the British cotton industry to he tested. (Seoplea already oollected and held at Kettering Laboratory.)" Because of Its Talus as a historical tie-in, tbs cocalttee accepted this recomaendatlon. !<B. Reference Standards "Tor control purposes and Improvement of biological aethods It Is eemUmvlated that testa on known concen trations of standard oarolnogene in standard solvents will be carried out with about 9 per cent of the animals received." Discussion of thie phase of work pointed up Its graving importance ae a fundamental tool needed by independent investigators In seeking ccsgarable and reprodaaills results. This shift In relative Importance towards fuadaavntal factors, such as solvents, dosage, and "co-carcinogens" was emphasized by s masher of mmbere. The comlttee accepted Doctor Kehoe'e offer to sutmit, within 60 days, a rerlelon of this Its to Include all known faotore and corrections of slgnifleant Importance to the establlahaent of standardised procedures. -4- ACTIO "C. for ?-,*1"nfi*d c Potencies of Petroleum frgqneta "Chemical research will continue an the two m i n approaches to this goal, ths satirical and ths funriMsntal. Animal tooting of fraction which ooa furnish useful Informtlan for this purpooo will, as In tho post, ho given priority over tort an proeoM samples. At tho earn* tim, It 1 recognized that an analytical tool has wary Halted, significance whan based on an inadequate number of biological testa of samples of Materials to which It Is to be applied. "Teats an nan-carclungedc fractions of various oils will be condnctod to dotezdns the effects of variations In the composition of these fractions upon ths total effective potency of ths oils It is obvious that If fractions which do not oontaln polycyclic carcinogens are Markedly affecting the rate of induction cf tumors in the test anlnols, then any tool based purely on the concentration cf p o lycyclic will be seriously United In general applicability." Members discussed the differing criteria used by investigators at Hew Tork Qhlvarsity and lettering laboratory and pointed out the dealrahlHty for a full exchange cf data in order to egpe&lte the completion of the best possible analytical tool. The comlttee voted to request these investigators to exchange all data of value incidental to the prompt develojeent of the best possible analytical t o d or tools "D. XPldealolnflae^ "Xffortf to expedite the oollectlom of ease records end other pertinent information on an industry-wide basis will be continued. At the present rate of reporting, there API 05182 should be sufficient accumulation of information by the tins of the spring meeting In 1952 to poxmlt & preliminary tabulation of the data." Doctor Phalr node a brief but complete outline of the program of epidemiological studies. The comsittee accepted Doctor Phalr'e report and program (eee Kettering interim reporta for past Id months far program details). 'I. xperlaental Study of Efficacy of Various CleansIre Agents and Shin Creams "As soon as the current testa uhlah employ rinsing vlth white oil and sashing with detergent solution hare been completed, new experiments will be started to compare hydrocarbon solvents, euch ae technical unite oil, with the viscous medicinal white oil currently employed as a rinsing material. "Further teste with other skin oreame will be designed on the haala of the results of the current teste with 1Yerex'." The nrumlttss offered no objections to the proposal except to suggest that proprietory cleansing agents and akin creams should not be Included la tofts unless complete fonmla Information is available, and that in mo oaae should trade names be used la reporting results. *F. Dilution of Carcinogenic Oils "Sixteen of the pvtlalpatlag oimpanlse have 1 reedy started, or oomplsted. aoJLlectlem of representative production blende containing carcinogenic etawarn from catalytic cracking cr recycle coking, together with date on the eoqiosltlon of three blends, t e aajarlty of the aambers API 05183 -c- ACnai zt the ccsmittee bar evidenced their desire for an analytical tool applicable to these complex mixtures. Since It la obrlcus that no suoh tool could bo developed without knowing the biological potency of at least a few of the blends, a elected group of these materials, on which detailed informtlon 1 available, should be subjected to salmi testing." Members cf the ccaalttee pointed out the endless complexities of mixtures occurring in refinery operations and the futility of testing two or six or twelve of the hundreds and even thousands of mixtures which would be produced la refineries during the progress of sash tests. The eamalttee voted against the collection of these production blende In favor of blending ample* now at hand for which analytical and biological data are already available. ACTIOi rr bU T l'H m T B car CARCgOOBOtS AMD SOLTHTTS A t the insertion o f L . C . Beard, Jr., I t was agreed that synthesis of aaoh earelaogon or solvent should bo considered Jointly by dirsotors of Projects JC-1 and 42, but that the Initial step la eaoh eaae should be taken by Doctor A. Wesley Barton by letter addressed to Doctor Barry Sutherland, Chairman, Projeot 42 Advisory Caeadttee, e/e Shall Oil Company, P.0. Box 1531, Modeetc, California, with oarbon eoplee to Dootor L . C. Beard, Jr., and Doctor Bobert W. Sohleeeler, Director, APZ Projeot 42, The Peaneylvsala State College State College, Pennsylvania. API 05184 7- nz Lamro appucaticb teste ob "higb-poipct* oils Dissuasion of this subject developed lnfomatioa if work already Independently by two investigators. It u a oooNofUf that the results of mark dona should be correlated oao. that additional work should be done if needed to supplenent the correlation. IT. to, MHJauaCJB3 IB RSPOBTIIB POOaCIP ACTIfli There was a consensus that the supplying of canglete data sheets was the only fseteal sasser te this difficulty) also It as agreed that nlcroseopy should be used to prove CoBsi&erutlon as given to the tine and piece of the second nesting of the advisory ooMlttee* dCYICt The ooMittee agreed that the seeead neetli should be held at Kettering Laboratory sonatina In februery or early Maroh, but left the exact date to be selected by the ohainem at a tine hen there would be no conflict with the Washington nesting of MBFOt Canutes D-2 or ether Important ladnetry nestles. TI oxnmaa Approved t M. I . Sewquist, M.P Chalmsn 11-29-53. rd D. Stroop doting Secretary API 05185 Dae< ir 7. 1951 3. B Raara, Chairman ^dieal Adrlaory Corvi ttaa /0 Standard Oil Company (Indiana) jXO South Michigan ATanua Jhiaaso 30, Illinois p ,tr O r. * m i I hara rasairad copias of tha lattors froa Dr, Fourchar and p. ada to rou aoncaming tha nuabar and rsprsasntatlon of maabarahlp 00 tha Raaaarch Projaat Adrlaory Co m i t toa. In tha iaausaion at tha Madiaal Adrlaory Coamittaa Haseing la Chiaago on Korsabar 3 1951 nantian as aada as to tha sisa of tas cornaittaa and ita rsprasantation. la astlon, hovsrar, vas taksa b* tha committaa on tha sa pointa. I ada a stataaant In tha mastlng that I would talcs suoh attors uitdsr adrlaaaant, but that va ust alao confidar lntaraat and knovladgs of tha subjaat or of sosa partinont pbaaa of tha subjaet as qualifiastlons for appoiotaant to tha oonalttoo. Inaavuch as tha Madieal driaory Conatittoc pasaod tha buck oj rafarrln^ to tha R.F.A. Conalttaa tha ramponaibill ty of working out tha raaaarch prograa on oarclnoganlolty for tha naxt yaar vlth rspratata tiras of tha Ksttsring Laooratory, it basano apoarant that tha eoanittaa raaoarahip ust Oa larga anough to inaura a vorklng quorum praaant at ita catinga (3 sabara did not attand tha flrat mastlng), tnd that lt must hsva adaqusta rsprassntatlon of quallflad parsons in ordsr to raaolvo tha various probias* at haod. In othsr orda, tha oritarion La tha Inportanca of tha Job to bs dons and not numbars or froa hors. tha firat oasting of tha R.P.A. Comal ttaa at tha attarlng Ubor tory on Mocaabsr 2 6 , 1951 aaaaad to aubstantiats tha ahora thinifing. At thia mastlng rarloua opinions vara prssantsd and rseon* oilad in a e origanial ataoaphsrs, objaa tiras vara ara adaquataly tafinad and auggaatlona as ta mathodslogy vara moda, all of shlah 1 1 1 (and to axpadlta tha aork and aacovpliah tha sbjsstlrsa at lasa ooat. As aoon as tha mors important problaas vlth raapaat to tha rssaarch program ara rssolrsd hlch ahould ba in tha raaaonably osar futura, it ould aaam that tha asabsrahlp of tha covai ttaa ould oa va tari11y raduoad in nuabar. Zn principia I thlnk that va ara API 05186 Reeve pr* 2 .'5- 7- a U" enaral Agreement, but the "--Ain thing ie to get the Job none 'll snd a* quickly a s pose 1ole. Very truly jours, M. N NEWQUTST. M D. MEIT'T'L DIRECTOR jPS oct :;r. Kenneth H. Fourcher ;r. Leo J. s vr. D. V 3tr< V ' t e n d e r :il Co. (:.J) Ksso tender* Oil C. API API 05187 l o T M t o r 29, 1951 , g. Poarehar, M.D. jt^dard Oli Co. (Pav Jareey) *0 toekofollor Piama l,y York 20, R. X. Daar Or. T w v b m ri ^c vili aakaevladge yoar lattar af Roraabar 26, 1951 partainlag to tba Jvajaah AArlaargr Ooaalttaa ef tha API. I bara alrea^y raoeid a ilailar lattar froa Dr. Vede la ragard te thia aattar. I aa w y eerry thia aatroraralal affair darelopad. ' " Tba telarti af tfciaaoaaiitee aa ft to D a . J awgaij aa lt aa falt ha to t p t d jtift aa ta aaabara ha oel4-be af.alia_te hla la thia attor. Aa Br.Savqalrt haa porr lattap aaAOr federa-lattar, ha la a w r a of yoar faallafa. X bara ritta Or. Iaqaiat aakiag for hi* spianatloa oeeerelag tha appoiataaat of thia nailttaa bat.4 jet baro et rtatirto a rapi/. X, par eeatlly, hed aothlag te.4a.vlth tha appaiatoast af thlf coa titta*. Aa atatad hafar, lt aa laft ta Rr. Bevfalet-ta ehoaaa th haabara. Tha only ^ oapaaiaa X aaa vhlah ha ta rapraaaatatlTaa ara jor laaaareh Dapartaaat, iarladlag Br. Xekardt ad Hr. dheperdeaa, aad tha Tana. Cpapeny, Inolndlng Air. haefcanii* and Or, lealt, Tbarefara, tha ahjaatlaa io sor thaa one rapraaaatatl lala SteadaN-Oll (lav Jeraaj) aad tha T a n a Coapeny. I voald thiak it aald ha r n y aagp far thaaa tao eoapaalee to eorraot aay ahjaatiaahla daplloata rapraaaetatlea Thara-ia a paaeiblllty that Dr. Savrmlat faltthatltaight ha dlfflaalt ta gai ali lfht aaabara togather at tha lattarlag Laboretarla.et: aaa tiaa far thaAr aaaaltaUaa aad ddad ora thaa tght ta git th prapar raprta-- tatifai .*.. . I n v Dr. Adaaa, y aaaaalata, yaetayday-ho lafaraad aa-thatv.thay hed a rary oastniotlaa^aaatiag lth tha lattarla# laboretarla ealereabor 26 and he falt tha oooaittoa-proaaat aaa arila ttry afflaIteti/., naaaaar, lt vpe-y odortaadlsg thaf -ell af tha aapbara af thia aaaalttaa ara art praraat. la aooa aa X bear froa Dr. lavqvlet, X hall ba-gled te aaataet ya* fttrthar. It aay ba paaalbla that Dr. lavqviat vili aeataat yoa aad Or. Vada dlraat la ragard to thia aattar. X aa aare thara aa aethlag lBtaatloaal oa tha part af Ih. lawqnlat la tha appolataant of thia aaaalttaa. Toara ary tra i/ , BBtig P". w_ r\ tt Nedlaal Dlraator API 05188 * -a S Of viOj r*e<I * % 4 eeR iia dnoo dT Iirev *>o 3000 Iqen ill* erfT 30*d Ioni -rari! rwoO -- 00 turi# ?90d orb* B I anco rid isda i sA - il 'yew .ifl :Hea Standard Oil company < W O O rO ftA T > B IN m w j b m b t ) 30 r o c k e f e l l e r P l a z a . N e w Y o r k 20, N . Y . D A f l S i M> D- . . co^^orc^. -- CTO ^ "'l roCBCHKR M D k ' *< r -- r w n lC i D I U C T O B Novewber 25 1951 F ilo 15.5 N O R B E K T J. R O B E R T S. M. D. JOHN J. TH O R PE. U . D. h a r r y P. C O L FE R . M. O. B B Y B IC U N O A T U B O I T . A R T H U R P E A R S O N . M. D. C O N SU L T A N T lA D IO L O O IO T PRA N K J. ROMMEL. M. D. S A R A P- W A G N E R . B. S.. R. N. O tB SCTO B o p N O B B Sf Dr. B. B. Peeve 5ten if. ra O il Company (Indiana) 310 South '.`.ichifcon rvenue Chicago 60, I l li n o is Deer Doctor Peer* Research Project Advisory Coaalttee. API Recently, 1 received the axmounceaent that Doctor Kewouist had appointed six o f the doctor* end six of the associate seeders o f the Subcoaaittee on Carcinogenicity to serve as tfca Feseareh Project Advisory C o n a itto o .' - - a ^ In th is action, I do not think that the intent of the-OtdlcaX Advisory Coaeitte# has been carried oat* I t spe c i f ic a l l y reeoeaendofi that only four o f the doctors and four o f tWr associate neuters o f the Subcostalttee be appelated to th is RPA Coitalttee, and that no two of ita aeebera oe froa any one coaceny. ?he wrrangcaent, as nov nade, is l i t t l e better thir. having the entire Subcoaaittee work on thia problem. I ca indeed extreaely aorrj that the aedsnre vfftad upon by the entire `iedieal Advisory Coaalttee has not been carried out ts directed, *nc I aa verj such afra id th at, in tbs astahlishaent c f this larger group, the o rigin a l purposa o f having i very fee people vork very closely with Doctor Rafaoa w ill be n u llifie d . - - I wonder whether, a fte r the aeeting o f the RFA Con- a ttte e in Cincionati to-day, i t would not be advisable to re designate the aeabers of the RPA Ccanittee in accordance with the Medicei Advisory Coaaittee's origin al reeoaaendation? Very truly yours, ERFIegf cc: -T. M. ti. Newquist Mr. D. V. S tr o o p ./ K. R. FOURCHER, X. D. API 05189 S t a n d a r d O il C o m p a n y (D*T>IA3A) S'pBPAHTMENT , oBKTK. M. D. t BIKiCTO* w BOIiYAM).M. D. a**, 'kxdICAL DXRBCrOR 910 South M ic h ig a n A vhnu* Chicago 80, lia* November 28, 1951 Mr. D. V. Stroop, Director Department of Technical Servlcea American Petroleum In stitu te 50 West F ift ie t h Street New Tort 20, New Tort Dear Mr. Stroop: The k e ttle appears to be b o ilin g in regard to Dr. Leo Wade, Esso Standard O il Company. Enclosed are conies of my le tte r s to Dr. Wade and Dr. Newquist regarding th is matter which you need not send out to other members. Do you know what th is is a l l about and what is your advice? Tours very tr u ly , t Medical Director m. d . BBR:S enea. API 05190 lovamber 2 9 , l251 M. S . Sevq-.ist, M.D. The Texas Company 135 2as t 2nd Street Kev Tort 17, N. T. Dear ? r . Ksvquiat: ?.'o doubt you have received a copy of Dr. Lao Wade's la tta r to aa per taining to the appointment o f your advisory ooc&ittee an careinogeniclty, ir. which he ha aerioualy protested your appolstuant o f more than eight neabers and more then one representative froa particip atin g companies. The only two coaoaniee I eee vhleh ere represented by two aenbers are your eonpany and the Standard O il Development Company vhleh la a part of standard O il (Hew Je rse y ). I would appreciate your understanding and opinion in regard to tn is . For some reeaon Dr. Wade and Dr. Foureber are d isaa tiafie d with some o' the procedures of th is organisation, the background of which ia not riser to me a t th is time. Toure tr u ly , Medical Director M.D. SMRiS -2 : Mr. D. V. Stroop API 05191 Noreaber 1951 Itso Wade, M.D. Standard Oil Coapany 15 Vast 51st Straat Eev fork 19, E. 7. Dear Or. Uadas I raoairad /our protaat 1attar of Roreaber 21, 1951 ragarding tha pppolntnante o f th a Research Project Adrisory Coratlttaa as tr> tha number of aaabers and cooperies*represented. is /ou know, tha appeintnect* of this eooalttee vara laft to Dr. Wewquiet with tha rmderatendinf that ho would usa good Judgasnt In srpolrtlng thia eoomittee. Tha only tvo companies T nota which have two representatives are tha "arse Company end your Standard Oil Development Company. I * aorry to here thia oontroraraiel attar develop end writing to Dr. Hevquist for hla understanding in thia aattar. Slnea It appeare that your Development Company end tha Taxai Cempany era tha only two involved, you ahaald ba abla in aoaa vey to atralghtan thia out between you. What are your reooanecdatioae Toura vary truly, 9HI 1 8 CC: Mr. D. V. Stroop Madioal Director M.D. API 05192 0S ' ,*15' r y AC* * Esso Standard Oil Company 15 WE9T 51st St re et ,n e w Y o r k 19. N. Y . November 21, 1951 CLYDfc U IU T PM 0 ^ 3. B. Reeve s*jiadrd oil Company (Indiana) South Hirhigen Avenue 30, Illinois itx >*. Reevei As & staler of the Medical Advisory Caeanittee of the A . ?. I., I ah to register a serious protest* Other aaobers of the Conaittee as veil as If vere led to believe that the Research Project Adrisory Committee vas to consist of not sure than sight members. Ho company vas to b e represented by xjt* ban one aaijer. the C amittee appointed is in violation of both these i^r&eaents. It fails to accomplish the end in viev, namely, a small group to writ intimately vith Dr. Kehoe and his staff. I see little advantage of this group over the entire Subcommittee. I realize full veil that the fo points mentioned vere in the nature a: "i gentlemen1s agreement" and not recorded in the minutes. It is unfortu nate that must faee the prospect of spelling out in detail our instructions to the chairman of tha Subcommittee in tne future. Sincerely yours. -V:HH Dr. M. I le v c u is t / Mr. D. 7 . fttreap / ' LD VIDE, M. D. API 05193 A merican P etroleum I nstitute SO W EST 3 0 t h STREET NEW YO R K 20. N. Y. December 10, 1951 "Ip TAC 5Y 1SAC C** - .M* J J OC iif^x or Members and Associates Subcommittee on Carcinogenicity . ^ ^^ Gentlemen: I am enclosing a copy of the minutes of the meeting of the Research Project Advisory Committee which was held at Kettering Laboratory, Cincinnati, Ohio, November 26, 1951 Will you kindly Indicate your approval or disapproval of the actions and decisions of the R.P.A. Committee on the enclosed letter ballot and return It to me. Negative votes should be accompanied by an explanation.I I will also appreciate receiving any comments and suggestions you may have concerning the research project at Kettering Laboratory. Very truly yours, MtN:GE Enclosure me: Members and Associates Medical Advisory Conalttee (WITHOUT LETTEE BALLOT) M. N. Newquist, M.D. Chairman, Subc ornaittee on Carcinogenicity API 05194 ft LETTER BALLOT of the Subcommittee on Carcinogenicity Medical Advisory Cornaittee American Petroleum Institute PLEASE MARK AND RETURN TO: Dr. M. N. Newquist, Chairman Subcommittee on Carcinogenicity c/o The Texas Company 135 East 42nd Street New York 17/ New York Shall the actions and decisions of the Research Project Advisory Committee, as shown in the minutes of the November 26, 1951 meeting at Kettering Laboratory, Cincinnati, Ohio, be approved by the Subconsaittee: Yes No* Not voting (* It is requested that any negative vote be accompanied by an explanation.) NAME COMPANY. DATE API 05195 LETTER BALLOT of the Subcommittee on Carcinogenicity Medical Advisory Connittee American Petroleum Institute PLEASE MARK AND RETURN TO: Dr. M. N. Newquist, Chairman Subcommittee on Carcinogenicity c/o The Texas Company 135 East U2nd Street New York 17, New York Shall the actions and decisions of the Research Project Advisory Committee, as shown in the minutes of the November 26, 1951 meeting at Kettering Laboratory, Cincinnati, Ohio, be approved by the Subcommittee: Yes _____ No* Not voting I (* It is requested that any negative vote be accompanied by an explanation.) NAME COMPANY. DATE API 05196 REPORT CN FIRST MEETING RESEARCH PRCJECT MC-1 ADVISORY COMMITTEE November 26, I95I Kettering Laboratory Cincinnati, Ohio mtMBERS PRESENT OR REPRESENTED M. N. Newquist - Chairman E. V. Adams L. C. Beard., Jr. Kieffer Davis R. E. Eckardt T. M. Frank R. M. Landon E. K. Linder (Rep. by R. D. Bent) K. G. Mackenzie R. M. Shepardson members absent and not represented C. H. Hine R. C. Mithoff QTEERS PRESENT F. F. Heyroth - Kettering Laboratory A. V. Horton - Kettering Laboratory Robert A. Kehoe - Kettering Laboratory John J. Phair - Kettering Laboratory David V. Stroop - American Petroleum Institute I PROGRAM OF PRCJECT MC-1 In opening the meeting the chairman outlined the aims of the Medical Advisory Coamlttee, and stated that the Research Project Advisory Committee had been appointed to afford a closer bond of understanding between comnittee members and research workers. Those present were handed copies of a "Memorandum from Kettering Laboratory on Further Prosecution of API Research Project MO-1 ," dated November 26, 1951 which was discussed and acted upon item by item as follows: "A. Process Samples for Animal Tests "1. Cracked residua from thermal cracking of virgin gas oils (samples to be collected)." Two samples of residua from thermal cracking operations at Everett and Aruba refineries were offered by R. M. Shepardson as products of thermal cracking operations which have been used without significant change for many years. API 05197 -2- ACTION action ACTION ACTION The advisory committee voted to accept the offer of the two samples. "2 . Sidestreams and residua from other cracking processes to he tested on a limited basis to improve analytical methods of estimating potency and further to test the validity of these methods (these samples already collected, analysed spectrophotometrically, and held in reserve in the laboratories of twenty-one of the participating companies)." In response to a question, it was explained that these samples were not fuel oil;, they comprised a limited number of existing samples requiring biological tests to round out data needed in the development of the analytical tool. The recommendation was accepted.. "3 . Untreated lube stocks from straight run distillation now being screened by analytical methods. Samples to be selected for animal testing on the basis of a comparison of their physical properties (including absorption spectra) with those of virgin distillates already tested." In the understanding that these samples comprised those received from the British Medical Research Council, the committee voted for a prompt initiation cf animal and analytical tests on the Oklahoma Bright Stock and Kuwait and Venezuela crude oils. "h. Scottish shale oil and fractions thereof. To gain further analogies between potencies to mice and potential hazards to exposed humans, two or three fractions of shale oil comparable to those employed as spindle lubricants in the British cotton industry tc be tested. (Samples already collected and held at Kettering Laboratory.)" Because of its value as a historical tie-in, the committee accepted this recommendation. "B. Reference Standards "For control purposes and improvement of biological methods it is contemplated that tests on known concen trations of standard carcinogens in standard solvents will be carried out with about 9 per cent of the animals received." Discussion of this phase of work pointed up its growing importance as a fundamental tool needed by independent investigators ir. seeking comparable and reproducible results. API 05198 -3< This shift in relative importance towards fundasental factors, such as solvents, dosage, and "co-carcinogens" was emphasized by a number of members. - The committee accepted Doctor Kehoe's offer to submit, within 60 days, a revision of this item to include all known factors and corrections of significant importance to the establishment of standardized procedures. "C. Analytical Techniques for Estimating Carcinogenic Potencies of Petroleum Products "Chemical research will continue on the two main approaches to this goal, the empirical and the fundamental. Animal testing of fractions which can furnish useful information for this purpose will, as in the past, be given priority over tests on process samples. At the same time, it is recognized that an analytical tool has very limited significance when based on an Inadequate number of biological tests of samples of materials to which it is to be applied. "Tests on non-carcinogenic fractions of various oils will be conducted to determine the effects of variations in the composition of these fractions upon the total effective potency of the oils. It is obvious that if fractions which do not contain polycyclic carcinogens are markedly affecting the rate of induction of tumors in the test animals, then any tool based purely on the concentration of polycyclics will be seriously limited in general applicability." Members discussed the differing criteria used by investigators at New York University and Kettering Laboratory and pointed out the desirability for a full exchange of data in order to expedite the completion of the best possible analytical tool. The committee voted to request these investigators to exchange all data of value incidental to the prompt development of the best possible analytical tool or tools. "D. Epidemiological Studies "Efforts to expedite the collection of case records and other pertinent information on an industry-wide basis will be continued. At the present rate of reporting, there should be sufficient accumulation of information by the time of the spring meeting in 1952 to permit a preliminary tabulation of the data." Doctor Phair made a brief but complete outline of the program of epidemiological studies. The conanittee accepted Doctor Phair's report and program (see Kettering interim reports for past 18 months for program details). API 05199 ACTION ` ' ACTION . Experimental Study of Efficacy of Various Cleansing Agents and Skin Creams ' "As soon as the current tests which employ rinsing with white oil and washing with detergent solution have been completed, new experiments will he started to compare hydrocarbon solvents, such as technical white oil, with the viscous medicinal white oil currently employed as a rinsing material. "Further tests with other skin creams will be designed on the basis of the results of the current tests with Verex." The committee offered no objections to the proposal except to suggest that proprietary cleansing agents and skin creams should not be Included in tests unless complete formula information is available, and that in no case should trade names be used in reporting results. "F. Dilution of Carcinogenic Oils "Sixteen of the participating companies have already started or completed collection of representative production blends containing carcinogenic streams from catalytic cracking or recycle coking, together with data on the composition of these blends. The majority of the members of the committee have evidenced their desire for an analytical tool applicable to these complex mixtures. Since it is obvious that no such tool could be developed without knowing the biological potency of at least a few of the blends, a selected group of these materials, on which detailed information is available, should be subjected to animal testing." Members of the committee pointed out the endlees complexities of mixtures occurring in refinery operations and the futility of testing two or six or twelve of the hundreds and even thousands of mixtures which would be produced in refineries during the progress of such tests. The committee voted against the collection of these production blends in favor of blending samples now at hand for which analytical and biological data are already available. ACTION II SYNTHESIS OF CARCINOGENS AND SOLVENTS At the suggestion of L. C. Beard, Jr., it was agreed that synthesis of each carcinogen or solvent should be considered Jointly by directors of Projects M > 1 and U2, but that the initial step in each case should be taken by Doctor A. Wesley Horton by letter addressed to Doctor Harry Sutherland, Chairman, API 05200 - 5- Project h2 Advisory Committee, c/o Shell Oil Company. P.0 Box 1531, Modesto, California, with carbon copies to Doctor L. C. Beard, Jr., and Doctor Robert W. Schiessler, Director, API Project U2, The Pennsylvania State College, State College, Pennsylvania. Ill LIMITED APPLICATION TESTS ON ''HIGH-POTENCY" OILS Discussion of this subject developed information of work already done independently by two investigators. ACTION ` It was a consensus that the results of work done should be correlated and that additional work should be done if needed to supplement the correlation. ACTION "" 17 PAPILLOMAS 75. MALIGNANCIES IN REPORTING POTENCIES There was a consensus that the supplying of complete data sheets was the only factual answer to this difficulty; also it was agreed that microscopy should be used to prove malignancies. V NEXT MEETING Consideration was given to the time and place of the second meeting of the advisory connittee. ACTION The committee agreed that the second meeting should be held at Kettering Laboratory sometime in February or early March, but left the exact date to be selected by the chairman at a time when there would be no conflict with the Washington meeting of ASTM Committee D-2, or other important industry meetings. VI ADJOURNMENT There being no further business the meeting was adjourned. Approved: M. N. Newquist, M.D. Chairman 12-10-51 D. V. Stroop_____ Acting Secretary API 05201 flayr tram 0. T. 3troqp for lafcrnatiQP cf X. 1. tawpiict. K.D. 12II-51 tadlda* 19 Ofcio i Capital Dfclfc 7, 1 9 . 9. 7* t d 50t t it n a o t r Dark 20, k v M i i Tor j w iataMttoi Z soatlas poa terovltb a rial-- n) of apaiitarao a k a W d f tf a t r U a M n l a i Institute tains tta bird artar of 29. Z tall* tat tta f t-- I li aolf-avlotetary, at if zoa boat m p fotaUaH of inaan f , Doctor KStao toolA agprodote m e talaglns tlaa to fcU ttaotiaa. Vary truly yours, // 1 B* FOrtlnss . A. Fortlaps, aocrstwy to Or. Kates tf API 05202 3. . .t far Informtlap af X. I. \ Krt. X. accomr c T S g H C T Far th Third tartar qf_1951 jut*ny A. s* * * : fJU 5rle S5J r U H y ffi H -- tlB UitMiar fait* Frajaet) $ lS.oo 22.27 1375.02 196l.*5 1125.00 1 2 0 0 .0 0 526.16 378.92 *oo.x 230.X 373*26 27*.50 162.35 lfc.00 99. 95.56 8297.72 990.31 397. *22.67 fctortlen of Boot, Om Ilaetrlelty, ftod ftfiUfi, ate. ................. # 33*5.39 6135.3* *,588.63 it fe* of 2k* tartar 1951........ $ 18,307.58 fctfrte - July 1991.................. 50.0. **1 8 68,307.58 - 3rd tartar 1951........ afc.586.63 AiallAl* fur Furthar Wort $ *3,718.95 * lad of 3rd tartar 1951......... API 05203 UNIVERSITY OF CINCINNATI ` KETTERING LABORATORY ACCOUNT OF AMERICAN PETROLEUM INSTITUTE For the Third Quarter of 1951 (Eased on Proportion of Time Actually Spent on Project) i/ihfirt A. Kehoe {jSncis Heyroth 'linn Pbair l e y Horton sell Tye '5,,th Pierle 0thy Templeton iyian Duvall rjdon Parkinson o h Denham -arrie Sivley tarl Kraut le do Younker . and Pelt a ?rank Cleveland prank Dutra Haymond Suskind Supervision General Technical Supervision Coordination of Exper. Technical Assistance n n n <1 II 11 II It n il n it it n n n r Work Pathological.Assistance Il ft Dermatological Assistance TSOUS EXPENSE 18.00 22.27 1375.02 1981.45 II25.OO 1200.00 526.I6 378.92 400.00 23O.OO 373.26 274.50 162.35 14.00 99.OO 9506 22.23 8297.72 ! 'raveling Expense Purchase of Animals 990.31 397.20 Laboratory Supplies Proportion of Secretarial, Library, Janitors, Wash Eoys, Draftsman, Shipping Clerks, Animal Caretakers, Histopathological Preparation etc .............................. Proportion of Heat, Gas, Electricity, Steam, Telephone, Postage, Pensions, Annuities, Maintenance, Animal Food and Supplies etc .............................................. 422.67 8345,39 II TOTAL 24,588.63 Balance Available for Further Work at End of 2nd Quarter 1 9 5 1 ................. $18,307.58 Beceipts - July 1951 ......................... 50,000.00 iotal Sum A v a i l a b l e ............................ 68,307.58 B*penditures - 3rd Quarter 1 9 5 1 ............ 24,588.63 Glance Available for Further Work at End of 3rd Quarter 1951 . 43,718.95 I t > API 05205 87, 1951 Dr. Robert ! Zbhoe Unitaralty of Cincinnati The lettering obarttory College of Medicine - Eden Aeenoe Cincinnati 19, Ohio Sear Doctor Echoes Paroaaat to oar contllaMtrton contract vlth the UBieerelty of Cincinnati, ocmerlag the cork oa inreeetigatian of the toxicity a d node of aetloa of certain petroleM redacts, m eacloco the 2hetltato'e cheek la the aeont of $31,692.b, which rvjreaoate the difforeaec between $50,000 end the unexpended of $18,307*58 * reported at the ead of the eoooad quarter, June 30, 1951* Ihle check ocapletes the pajaente dae airier the procent contract far the /ear ending Jane 30, 1958. i DIB sc oe: Dr. X. L Linder Dr. M. I. Beeqalet Tory truly /our , loto to Mr. Walker: Thle expenditure le to be charged agalnat the Medical Reaeareh Pand. DVB API 05206 ladonatort UNIVERSITY OF CINCINNATI department of preventive m edicine and in dustrial health December 2 S , Irpl CARLE ADDRESS: KETLAS. CINCINNATI TELEPHONE: C A m o i MM mr . d . V. Stroop, Director reoarnnent of technical Services ijierioan Petroleum Institute O Vest 50th Street jiev York City 20 pear Mr. Stroop: I herewith acknowledge with thanks receipt of American Petroleum institute's check in the amount cf v -1,692.42, covering expendi tures to be made on their behalf. Very truly yours Y R ^ o r t llaagg^^., Secretary to D r . Kehoe ef API 05207