Document 2qv0B1yjG5BO9mbXo33kkG6Dg

r EiQ'jr L 3: William E. Smith, M.D =o rn U 'eb i. 3 3a1 time re , Me Education: Princeton University , .-..3. (19 34 5 Johns Hopkins School c; Mealcine, M. 19 2 3 Experience; Fallow in Bacteriology, Harvard Medical icncci !2os; .on, 1938-39. Fellow in Medicine, Mass. General Hospital 'Boston) 1940-41. Assistant in Bacteriology, Harvard Medical 5chcol (Boston) 1941-43. Assistant in Pathoicqy, Rockefeller Institute for Medical Research (NYC) 1943-47. Associate, Sloan~Kattering Institute for Cancer Research (MYC) 194 7-M . Assistant Professor of Industrial Medicine, Mew Ycrx Universi Bellevue Medical Canter (NYC) 1949-52, Associate Professor ib L3 1952-56, Research Professor, Fair Leigh Dickinson University ( U . J . i 1957-59. Professor of Health Education, ibid. 1959-64. Assist ant Clinical Professor of Community Medicine and Consultant, Divi sion of Environmental Medicine, Mt. Sinai School of Medicine (NYC) 1966-1974, Director, Health Research Institute, Fairieigh Dickinson University, _(Madison, N.J.) 19 5 9*i0^-~7VS Z^. ix.il y'/ 1 -o' h iif/'KM V*' , /VJ5 Scientific Societies: American Asso-.vation of Pathologists. American Association for Cancer Research. An\eric4ir~Tndns'tro:al ^_HysiAnft=^4UiciationT. Editor, Proceedings of Cancer Prevention Committee (A.M.A. Arch. Industrial Hygiene and Occupational Medicine 5:185-299, 1952). Member, committees of International Union Against Cancer: Louvain (1952), Sao Paulo (Chairman, Committee on Cancer Prevention, 1954), London (1958), Tokyo (1960). Group on Chemical Carcinogenesis, National Institutes of Health, Beidiesda (1967). Invited speaker: Conference^on Lung Tumors in Animals, Perugia (1965). Conference on Biological Effects of Asbestos, New York (1965). II International Conference on Biological Effects of Asbestos, Dresden (1968). Conference on Morphology of Experimental Respiratory Carcinogenesis, Oak Ridge National Laboratory (1970). Bureau of Mines Symposium an Talc, Washington (1973). Institute of Occupations and Environmental Health Conference, Montreal (1973). Workshop on Protocols for Testing Man-Made Fibers in Animals, Tarpon Springs, Fla. (1975). WHO/IARC Symposium on Biological Effects of Minsral Fibres, Lyon (1979). Publications: 20 papers on organisms of pleuropneumonia group, bacterial variation, tumor viruses (1942-52). 40 papers on chemical carcinogens, especially cests for carcinogenicity of petroleum derivatives in mice., rabbits and monkeys, and gf asbestos and other mineral fibers in hamsters (1945-80). , __ _ 5 papers on experimental cancer chemotherapy (19 80jf-83) fpy.-: /t7 -- ,, . , . 'V - ' 1 /j^ ' 7 . Y 7S'l 1 fi/\/Itic [l>L 7 Asterisk (*) ir.d SUm.LZC2C 3. 5XT1-L--I*--S *a 10 , Ill Eous , ?., ar.d Snitr. . '-M.. "The neoplastic potentialities of mreus embrvo tissues. ir.d mgs with skin cf C strain emtrvc :ranssla.tt3d :c adult initials." Zx-p. Met. , 81:597-520, 13 Smith, W.I., and Ecus, "The neoplastic potentialities of mcus embryo tissues. 21. Contributory experiments: results with t skin cf C2H and Weesser-Swiss emoryos; general considerations J. Exr. Med., =1:521-546, 1945. 7^ * * -- > -- / Med. 'T^s r.2cclzs*i.c cc.sr.tiiiit-2S cr rr.cusc smcrvc sitbeliun. " J. Exp. 35:459-47=, 1947. it*o in Smith, W.E., and Ecus, ?., "The .neoplastic potential!ties of mcus; embryo tissues. IV. Lunc adenomas in baby mice as result c prenatal exposure to urethane." J. Exp. Med. 88:529-354, 1 *! tn r: n neoplastic potentialities ci mouse embryo tis V. The rumors elicited with methyichclantirene from pulmcnar epithelium." J. Exp. Mec., 91:37-104, 1950. a*-: - f f w *o th. W.Z., "The materials for * W.E., D.A. of the carcin ?? . 29-9-514 i; Hoilir.c Catalvticallv Cracked Oils. Health* 4 :299-*214, 1951. A.M.A. Arch. Environ. Sunderland, C.A. , W.E. Smith and K. Sugiura, "The pathology and growth behavior of experimental tumors induced by certain petroleum products." Cancer 4:1252-1245, 1951. Smith, W.Z., J.G. Kidd and P. Ecus. "Experiments on the cause cf the rabbit carcinomas derived from virus-induced papillomas. I. Prcpagaticn cf several cf the cancers in sucklings, with etiological tests." J. Exp. Mad. 95:299-513, 1952. Ecus, P., J.G. Kidd and W.E. Smith. "Experiments on the cause cf the rabbit carcinomas derived from virus-induced papillomas. II. Serciccicail r-u- ntimes. J. Exo. Med. 95:139-174, 1952. crp-i ^k t W. . t "Lunc cznc2r srsci.3.2. 2r2r.es *10 Xpcr*n^snli2.1 asoects." A.M.A. Aren. Incust. Hvc. i Cccuc. Med., 5:209-217 1952. Smith, >4. e . , " Survev cf seme current Hritish ar.d Eurcoean studies of occupational turner problems." A.M.A. .Aron. Indust. Hyg. i Cccuo. Med. 5:242-255, 1952. Suctura, Y. cf carcir.cna ir. tr.esus mcnxeys. ir.c. ix;er:-er.:a: product::li*csir P.ssssLrrn ^joci.scs t 14. Smith, W.E. Experimental studies. Chapter 2, ?p. 12-40, ir. PULMONARY CARCINOMA: PATKCGENEEIS , DIAGNOSIS AND TREATMENT . Edgar Maver and H.C. Maier, Eds. New York Umv. Press, N.Y'I 1356. Pp. 540. 15. Smith, W.E. Environmental facttrs ir. cancer with comment cn scr.e applications cf a rapid test ccrrslatirg with caroinccenicioy. Acta Cnio Ir.terr.at' 1* Centra Car.cru.-t XIII (1): 77-35, 1357. 15. Smith, W.E., L. Miller, R.E. Elsasser and D.D. Hubert. Tests for carcir.ccer.icitv ci ashestes. Ar.n. New York Acad. Sci. 122 (Art 1): 455-433, 1355. 17. Miller, L., W.E. Smith, S.W. Berliner. Tests fer effect cf asbesco: cr. benro (a) cvrer.e carcincger.esis in the respiratcrv tract. Ibid 122 (Art 1): 489-500, 1955. 13. Smith, W.E. , L. Miller, J. Churg and I.J. Selikoff. Mesothelicmas in banisters following intrapleural injection cf asbestos. Jcurn Mt. Sinai Hcso. 32:1-0, 1965. \ 19. Smith, W.E: - Asbestos in'relaticr. to tumors cf the respiratory tract ?p. 565-570 in Lung Tumors in Animals. L. Sever!, editor, Univ. Perugia (Italy) 1966. 20. Suruki, Y., J. Churg and W.E. Smith. Phagocytosis of asbestos fibers by epithelial cells. Laboratory Investigation 13:225, 13 21. Smith, W.E. , D.D. Hubert, L. Miller, M.S. 3adollet. and J. Churg. Tests for threshold levels cf carcinegenicif/ cf asbestos. Paces 240-242 in Proceedings, Seccnc International Conference cn 3iclogical Effects cf Asbestos. Dresden, 1363. 22. Smith, W.E., and E. Yatdi. Induction cf carcinomas from mouse lung transplanted with asbestos. Proceedings American Association Cancer Research 10:84, 1969. Smith, W.E. Mescthelicrr.a in relation to asbestos. T Report. Grant No. 3R01 EC - 00116-0451. 3/21/1970. Smith, W.E., L. Miller and J. Churg. An experimental mccei for study cf cocarcinocenesis in the respiratcrv* tract. Paces 293-3 in Morphology cf Experimental Respirator*/ Carcmccenesis. AEC Symposium Series 21, 1370. Smi*"h, W.E. , E.L. Cutie- and D.D. Hubert. Effects cf ccLv T:C cr. Research 12:34, 1971. e p it_r.eln ir. m: sentii Researc: in respcr.se rc Hygiene Assn. . ind L. Millsr. C^r'cinocsr.ssi; * - cu1t.c--s--. :r. different levels cf vicsr.ir. A. Er.vircr.- 3 ^ 1 ' o " Biologic differences r.c ar.c snort asnestcs f=in--e0 r-- 1 2 2:A 152 (Fes, "i Q ' Airier. Indust. .th, W.Z. Asbestos, talc and nitrides in relation to castric cancer. Amer. Incest. Hycisr.e Assn. 24 : 22 7-22 8 (Mav) 1ST 2 = or or, . r.. k r* -- ^ 1 ^ ^ csmrccenesis as related tc ^*hra "8072****' Fibres fer Biological Ixteri.tsr. Transcrict cf tr.e Institute cf Cccucaticnai and Ervincrmertal Health Ccr.farer.ee, Montreal, Cct. 29, 30 , 1272. ?. V. Pelr.ar, Hubert, D.D., W.Z. Smith, 1. Dcerries and ?. Weissman. Effect cf asbestos cn lung clearance cf bento(a)pyrene in hamsters. Abstract Mo. 26. Alter. Incust. Hyc. Cent., Boston, (May) 1972 Smith, W.Z. Experimental studies cn biological effects of tremcl: talc on hamsters. Fp. 43-43 in Proceedings cf the Symposium c Talc. Washington, D.C. Information Circular 8629 . A. Gccdwi comp. U.S. Bureau of Mines. 1974. Smith, W.Z. and D.D. Hubert. The intrapleural route as a means fc estimating carcinogenicity. ??. 93-101 in Experimental lunc Cancer. Carcinogenesis and Hicassays. Zd. by Z. Karbe & J.F. ?ark. Springer-7erlag, 3eriir/Nev York 1974. Sabeiman, S. Wa.tr.an, W. Smith and S. Douglas. Appearance cf C type virus-like particles after co-cultivation cf a human turnc cell line with rat (XC) cells. Int. J. Cancer 16:355-369, 197 Scbel, H.J., Z. Marquet, W.Z. Smith and D.D. Hubert. Asbestcsinduced mesetheliemas in hamsters: similarities to human mesotheliomas and presence cf type C virus particles ? sd 2 *"2 c Proc., in press. Smith, W.Z., D.D. Hubert, H.J. Scbel and E. Marcuet. 3iolcgic tes.. cf tremclite in hamsters. In Conference cn Cccucaticnai Zxocs to Fibrous and Particulate Dust and Their Extension into the Environment. Wash., D.C., Dec 2-7, 1977. Society for Ocoup. and Envircn. Health. In cress. Smith, W.E. editor. ?,'cc2ocir.cs c he Cancer Prevention Committe A.M.A. -.".oust. Coouo. Med c . 1 35-232, 1252. Smith, W.E. S vrr.ee s i um cr. C3r*c2zr Pirsv^sri wi.cn- SixcM Ir.12r* national Cancer Cor.cress. Sac Paulo. 1954. Acta Ur.io Internat Contra Car.crum. v r - - Ml 10V For Resolutions, refs to pp. 151-155. 38. Weil, C.S. Cancer and experimental design. Discussion of dose- responses, time to tumors, species variability and route of administration. Document submitted to CSKA Docket No. H-090. * 39. Page, R.C. , et al. Symposium on a Cancer Control Program for HighBoiling Catalyticallv Cracked Oils. A.M.A. Arch. Environ. Health 4 : 29 7-345, 1951. * 40. Wade, L. Observations on skin cancer among refinery workers. Arch. Environ. Health 6:730-735, 1963. * 41. Amer. Confer. Govern. Indust. Hygienists. "Threshold limit values for chemical substances in workroom air adopted by ACGIH for 1977." Refer to p. 40. 42. Wagner, J.C. Experimental production of mesothelial tumors of the pleura bv implantation of dusts in laboratory animals. Nature 196:180-181,' 1962. 43. Stanton, M.F. and C. Wrench. Mechanisms of mesothelioma induction with asbestos and fibrous glass. J. Nat'l Cancer Inst. 48:797821, 1972. 44. Stanton, M.F. Fiber carcinogenesis: Is asbestos the only hazard? J. Nat'l Cancer Inst. 52:633-634, 1974. 45. Stanton, M.F., et al. Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J. Nat'l Cancer Inst. 58:587-604, 1977. 46. Stanton, MIF. and M. Layarc. The carcinogenicity of fibrous minera Workshop on Asbestos: Definitions and Measurement Methods. National Bureau of Standards and OSHA. 1978. In press. 47. Wagner, J.C., G. Berry and V. Timbrell. Mesothelioma in rats after inoculation with asbestos and other materials. Brit. J. Cancer 28:173-185, 1973. 48. Pott, F., F. Huth and K.H. Friedrichs. Tumorigenic effect of fibrous dusts in experimental animals. Environ. Health Perspec tives 9:313-315, 1974. 49. Turner, F.C. Sarcomas at sites of subcutaneously implanted bakelit disks in rats. J. Nat'l Cancer Inst. 2:81-83, 1941. 50. Druckrey, H. und D. Schmahl. Cancerogene Wirkung von KunststuffFolien. Ztschr. Naturforsch. 7b (6): 353-356, 1952. * 51. 52. Druckrey, H. und D. Schmahl. Cancerogene Wirkung von Quarz bei Implantation an Ratten. Naturwissenschaften 22:534-535, 1954. Oppenheimer, B. et al. Carcinogenic effect of metals in rodents. * Cancer Research 16:439-441, 1956.  53 01 Gara, ?..W. and J.M. Srown. Comparison cf the cartinccer.tr actions cf subcutaneous ir.plants cf ircn and aluminum tr. J. Nat'i Cancer Inst. 22:947-957, 1967. V4 r-s vo f Ban w.n. Pa Ire JAMA, Auc. Letter ts tr.e setter--Money Cause 1977, Vol. 223, Nc. 5, p. *297, Heucer, W.C. and W.W. Payne. Experimental studies in sietai carcir.ccenesis: chromium, nickel, iron, arsenic. Arcu Health 5:445-462, 1962. 56. Heuper, W.C. Cancer induction by pclyurethan and polysiliccr plastics. J. Nat`1 Cancer Inst. 22:1005-1028, 1964. ' 57. Sass, 3. et al. Incidence cf spontaneous r.ecplasrs in 12 4 4 r thrcuchout the natural life-scan. J.' Nat11 Cancer Inst. 1455, 1975. 53. Bender, E. et al. Mesotheiicme beim Golchamstsr. Arch. Geschwulstferse h. 41/3:207-216, 1573 . 59. Menhert, W. et al. 42/1:22-25, 1974 . 60. Wagner, J.C. et al. The effects cf the inhalation of asbesto rats. British J. Cancer 23:252-269, 1974. 61. Gross, ?. The effects offibrous glass dust cn the lungs of animals. ?p. 169-178 in Occupational Exposure to Fibrous NIOSH Division of Criteria Documentation and Standards Development. 1976. * 52. Gross, ?. The biclccic cateccrizaticr. cf inhaled fiber class Arch. Environ. Health 21:101-107, 1976. in n. n 62. Gillam, J.D., j.M. Dement, R.A. Lemen, J.R. Wagoner, V.E. Ar and H.P. Blejer. Mortality patterns among hard rock ccl exposed to an asbestifora mineral. Ann. New York Acad. 271:226-244, 1976. 54. Dement, J.M., R.D. Zumwalde and X.M. Wallingford. Discussicr. asbestos fiber exoosures in a hard rock cold mine. ibid I 245-352, 1976. * 55. McDonald, J.C., G.W. Gibbs, F.D.X. Liddell, and A.D. McDonald. Mortality after long exposure to cummingtonite-grunerite. Presented at Annual Meetinc, American Thoracic Society, Ms 1977. * 66. Grcss, ?. et al. Ingested mineral fibers. Do they penetrate tissue or cause cancer? Arch. Environ. Health 29:341-347, 67. Gibel, W. et al. Tierexperimencelie Cntersuchur.cen uber erne kanserccer.e Wirkung vcr. Ashestfilterr.aceriai r.ach craler Aufnahme. Arch. Geschwulstforsch. 46/6:437-442, 1976. -j rt 68. Storeygard, A.R. and A.L. Brown. Penetration of the small intes mucosa by asbestos fibers. Mayo Clinic Proc. 52:809-812, 19 * 69. Smith, W.E. Report of 28 April 1976 to Mr. X.M. Haley, Reserve Mining Company. * 770. Smith, W.E. Report of 15 February 1977 to Mr. A.H. Samuel, Rese: Mining Company. * 71. Champness, P. Deposition 28 April 1977.. 72. Cunningham, H.M. and R.D. 56:976, 1973. 73. Pontefract, R.D. and H.M. 74. Cunningham, H.M. and R.D. asbestos Naturei 249: * 75. Stewart, I.M. Selected thoughts on asbestos quantitation. Pp. 9 in Symposium on Electron Microscopy of Microfibers. FDA. 197 76. Cook, P.M. (Electron microscope analysis of urine samples) Lett (' of April 11, 1977 to Ms. Pamela P. Quinn, Water Quality Divis Office of General Counsel, EPA, Washington, D.C. 77. Cook, P.M., G.E. Glass and J.H. Tucker. Asbestifora amphibole minerals: detection and measurement of high concentrations i municipal water supplies. Science 185:853-855, 1974. 78. U.S. Court of Appeals /for the Eighth Circuit. Decision filed March 14, 1975 in Reserve Mining Company et al vs. Environmer. Protection Agency, et al. Refer to p. 47. 79. Glass, G.E. Identification and distribution of inorganic compcne in water: What to measure? Ann. N.Y. Acad. Sci. 298:31-46, 80. * 81. Smith, W.E. Report of 4 February 1976 to Mr. X.M". Haley, Reservt Mining Company. * 82. Smith, W.E. Letter of 7 July 1977 to Mr. Edward T. Fride. 83. Stewart, I.M. Asbestos in the watersupolies of the ten regional cities. Final Report on EPA Contract No. 68-01-2690. EPA 560/6-76-017. 1976. 84. Moore, J.A. NIEHS - Oral asbestos studies. Workshop on Asbesto Definitions and Measurement Methods. National Bureau of Standards and OSHA. 1978. In press. es 36 87 * 33 * go Greener 197 4 as. grit. J. Ir.cusi. Med. 21:91-10 .'laser., T.J. , 7.W. McKay ar. Duluth wa:sr succiv: 1019-20, 1=74. Miller. .Asbestos-like fibers 1-be career mortality. JAMA 21 Levy, 3.S., Z. Sicurdscn, Investigating possible Surveillar.es cf yastre Am. J. Zcidemici. 102 Mar.cel, Z. Laudon and J. Pearson. ' ifecus of asbestos in city water: testiral incidence in Duluth, Minn. 62-263, 1375. y in relation to asbestos in nuricit rvaron. Health 22:195-190, 1977. il 1375 to Mr. X.M. Haley, Reserve * on Bacciler, anc *. A. ^ an 1 Precaraticn c asbestos fibers experimental use. Ann. New York Acad. Sci 132(Art 1): 451- (