Document 2qrvm6NOpX8pgozEZGoYpR6Nb
AR 426 -- 14HT
HFALSUEEITRNmCGATRiOBNOnwNoSRRDs1vTSION PARKERSHURG, A, vi,
ee: GJoJ.:.FbFM..itYRcZoehoriewgnl/ahl6na,,.rdJtH5r,i..,skaSestProlk)paepslettl,aipc.fFsaavs,ken 1a, CFEl.D3.S.heHrGosrarisar,rteyreHnnaesyk)elIl Ttasu,r, Ha--s_kell ra5. ay 8, 1970
TOTLGICAL DFORUTION on cq rm
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ne telephone roma 418 LILu%ndeurssitnagndC1G8E,RCyouforcucrar.enBt0lypearreeuestinogsc,rAeP.FTCo,
comnts
but are
of Apri)
phasing
16,
Ccohlroernenfdiocnaecibdiafmoarri`ztheed otthheerav20ilpaebrlecetnot.xiciAtEyT
die acid 1
1s notusedr,1on Polymertzingitant information on CaaPr
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three. CAPR and CoAPRO enups
oirsalthdeoslaogweessttTuedpyeated oral dosage th
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ora Jevala.
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ShiKnaettreachtyhs."orW2ei%nhacovtaehteenro SLiipnvefecoriremesantlaiasroonweenmlelen,ti,hteE.haxutceoeJrxpvslteaertrfctoyrenoltfhaerdtgihkesinmusoecwncmltaetdeegfrefieactlhtaatorcecchuslriosarteonindalirycsy
taste:
To
aa4ver the
initial
toxtetty questions
on
intc actd perertan CGAPIC, T suggest the following
TI.
Determination of lethay Tdeetteerm(iMnsattoipoanthooflolgoyweosft
oSroaalsednotsraagteioc:aubsyinsginlgile
oral
doses
and
600
5
S
liver ents),
ver enlargement in
g
EID072196
=
000086
DWS 1036533
WE. Rilten
Page 2
May 8, 1970
TH.
dccumilation in the
(two-week subacute
rat
to
cause
ver
enlargement
TIE
PJAeRcOmLuOlSatLiEonexatmai
,
ntahtei
oral dosing),
oantoftothleestuheasl,
lesvveatls
d(eveise'Bato-
TT S58ITRatTafatleryorfaolr dreevgriensesion of Liver entargement 10
"fS0iemiseansuMrtaehte,oLtiEsvteRersEteinotananrdgscukaimnnntSs]eo.rdpattiovnintomnieeettny ((CthhiLs24,1a
VI.
TIT
PRAeEpReOaLtoeRdYapbuptliwciatthioenxasmkiinnataibosnorpottiosnyvesrteusdy without histo. [rior ska trritation and sensitization (sa
0in dtehetegrumiinneaP1t8haerned c13anabienidronieonvtithTveenrouogohyegtuiiagnnoeadoPpn1ie8gs
VIII. Eye irritation,
$750
#1100 #1000 450
`1500
3200
IX. sRaetpheoaltoegdy,(two-weex) inhalation administration with bistoT fGionoanltemvtadlouantioofn.the shove progres, taterta reportsand
300 "2000
"sg
13 materially t1o3"th,erlcaosrts.emmInntaevaluation 1a the above station as not added
Tradesae So0% ch, 30,000. They Trud Tats and dogs including aone-dgdeinteiroant,iowneTeTpercoodmuecntdioan-5t0e-rday feeding study in
y La meciction-t because ve have no chronic DSetpuednidesingononantyheofTe`these surfactants ang 80 adequate st atogen study in rats,
ad rats, night be indteacea' sults
of this
9-day study,
a
udies Protracted
in gon-rodent stu
species,
dy in dogs or dogs
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EID072197
E
000087 DWS 1036is534
4. E. Elton
Page 3
May 8, 1970
none
rare San eltntnate
of the repeated io
continious
exposure
to
cairre
by
tanalation,
Deeleidmifnoartiaonreopfearteepdeastkeidnheaxlpaotsiuorne sbtuydiseksinwaoduslodrpbteionnecweosusladr'y,elSiimilarly,
GFfoohourvrraecrihhnnlidonuragsetinrttdhieiearcleaLxhctyatagtanie.etnntiosftt,untaeoMbrs,dtoeorxvpMteotclriiogosapnyni',ntgtoeaxtssihtceiitnhtsgeyemmbsootesunotdrnyie,bese"nte1ofxTiShicuicigsiaglevsontmueilxandtavtaise1tsseitgpthetboy
ty testing program
RAStVt:acghmment
RESEARCH MARNIACGEERA,D B3.10-wSaCrIeEzNCES Gove
-
000088
T
wl
EID072198
DW 103653s5
SSROMAURREYOOFFTTROIXCICIITTYY DDAATTAISOONRCCaaAPPRPCC 4AN8DCCHHLIOORREENDDIICC AAcCTTDD
Test
TOroarlnaApSpervoexizate
Oral liver enlargement
Oral Subacute
Sgirre 670 ng/xg
60-90 ng/kg
ND
Approximate Lethal
Dose
_--
0.8 mg/L
(caused liver enlargement)
Chlorendtc Actd 5000 zg/xgws
Fo
0"8 x
caused
eet) 1000 mg/xg
seven deaths
ND
Chlorendic# anhydride 1000 mg/kg not lethal
No
ae) 8 x
#ix
1000 mg/kg
deaths (10
caused
rats
ND
(Respiratory irritant in rats).
? rDoattataftreormaHtonoakaer Chemica
*} = BA*ERl} Jabgratory found 2250 mg/kg
:
0000899
EIDO072199
Hy $ 1036-536 *