Document 2qO62M7dBz6EZVbB3B0vDq2dN

Thi Shervln-UllllMM Conpany FC.eb6ru. aSryeh8u,rr1978 Research Proposal (Explanation) Than aoaoa to bo llttlo doubt that pa1st films containing 0.^ lb on tbai drlad aolldo would ba toxic to a child ifi 1) Iha child ingested * 11 ea* of thick (0.089 |i./a>l) peine fllaa par day for long parioda of tiao. 2) All of tha load in dia paint fila could ba extracted froo tho paine flla by digestive flulda. 3) Ibxlcity ia defined aa any Incraaee in blood load level above Id) ^g/ 100 nl, tho aarfana neraal laval. the quaetIona, than, that should bo ananorod by a definitive raaaarch project would aoaa to at least Include tbs following! l) How auch loose paint chips does a child who baa plea and has paine chips avallabia actually aatT 8) How wall can tha dlgsacivo fluids sxcraee load fron o paint chip that has boon palvorlaad only to tha extant that a child with pica would pulverise a paint chip Pham anting itf 3) Can anneal retardation (idiich scans to bo die clinical synpton nose snapactsd fron low -- JD4) |ig/10C nl -- blood lead-lersls) bo studied in test aninelsT Thorn are other gnesclana that should ba posad particularly with respeat to the toxicologleal offsets of substitata driers and to tho effect of load "free" paint filns on old high lead points - but those will bo discussed later. Iha nrgwonts advanced by 9c. Horry Hag supporting the Ingestion of ~ ll of thick point filn per day by children with plea appear to bo odbjoet to a geod deal of possible oner. As srgunsnt depends an tho density (Orads 3) of x-xnya of cbildxon who how saean "nibbtsh" end the aasunption ehot all of tha dually resulea fron the presence of land ia tha a touch. Obviously way other rnnjootnra of rubbish could eontriboto to tho x-ray daasity such as calclw fron chalk or bariun fron barytes la old paine Him or titaaiu fron titanlun dioxide in paint filns or own iron few rust. The other argunant dopends on tho fecal lend eontent of n child suffering few load poisoning uho bad oaten point containing 9.5$ lead and calculating both to dotaeniae bow ouch toad paint tho child bed nates to 0007-SWP-037118 N22930 |in that fsesl lead content (lflO ag.). Ala appears ca ba abase 9 gram or 11 * af chick (O.lfij / *) palat flta. havercbeltas, aChac aspects have suggested oaa ar M ar aa a aotoal aaauat al palac Ilia aacaa dally by a chili with ylaa. taaca la ear labacacarlaa have ahem Chat 0.55 K1 will aaecaec about kOf of the lead Is this (lisa (85 - 90g) durtag A baa* a>traction Caaca. Mack by (Bus aad UtehClald (lOCtt, i960) ladieacad chat rat acaaaeha astraeead abase JoT af laad fruu laad drlar aad 296 lead frow laad pi^mtt aaacalaad la wall |ul> vsritad palae film chae mra Cad ea Aa raea. If m eaka Aa factor af 5 (11 etP/g ca*} elma Aa faccar af g-1/2 (1005 eol./ b05 aal.) aad wsltlply ehaaa dm Aa 0.065 (laad 1ml advacatsi by Aa Aaricm Acadaay af Mdlatrica baasd aa lacaaelsa af 11 ca* of palae par day f--Cclhtsg coaplaAly aelubla laad) vs get a Cigars af 0.7305 Vb. Ala la mil alMwa Aa Isrsl af 0.95 advocated by Ac food aad Drag JMhatalaevaetsa aad suppstead by Cba palae Induscry Ala pataca auc Aa tsparcaaea af ACalalag aacvrtca dau aa Aa aamt af palae a child sill me aad aa Aa solubility af laad la patat Alps A dlgaac&va fluids. Aa Mad aad Drug AMAAtratlm baa pcepaaad a laad Halt A palats far lahabiCad dmlllaga of O.95 aad Aa palae Aduaeiy baa aspparead Ala loml. Ay 0.95 to* acaad af O.35 r 0.76* 1 good aaaaar A tbae this A Aa lamac level af laad Aae will aoe require Aa was of subatltuta drlars A paAe film. gabseiAM drlara am bad far em raaaoaa: 1. Aay hava mfcnam eaalcalagiaal affaett. 8. Aay hava aakaova sffaau aa palae film. Therefore, It la proposed that As rsaaarch prajact should laslads Aa etugy af Aa toxicology af cabalt aad ealaiwa. AA caa A daaa at a roassaablo amt aloes Aaaa drlara cao (aad dwli) ba used A Che law laad paAta ae lavsla above Alch-they are used la laad cmealatag pa(a(i. It also A pmpsasd Aat affects aa Aa palot film should bo aeudiad. d m poaai> bla ar avm probable offset frea ualag higher lavsla of eobalc la gmatar ihrlAaga, and laaa ability ca raise far Amo palae film soapsred ea ataller film amealalag laad drlars. AA caAlaaelsa of ehrAhaga aad aciffaaaa will apply asm etnas m all paAe film Am asch palnea am mad os mils wiA aAsagome graatar cbaaaaa af ramlng Aa aid palae to peal. Aaa, if As eld palae happoaa A ba high laad paAe vs rnU A vaklog laad aora availabU to Aildma with pica by ualag lead "fraa" palsta. MAc film burnt ea ail ar slkyds dry by oxldaelm aad pelyaartsacAa. A a drlar laad promcaa palymrAacim rsAar Am ealdatiea Asnaa cabalt peamcaa oaidatlea eaAar Am polyaarlaatloa. Mckari (Baft. Saee. Clr. hob, 1991) ahaaad ebat AevamAg aamaA af laad drier A ltaaaad Al decreased the vaAtila Ima frm llmaad all (AiA eovld ba arpanfad ca deeraaaa Arlakago). Aa Nsactaal -2- 0007-8HP-037119 0007-SWP-000118411 Faint Production dub (Official H|ut, ljUj thovod cobalt and aangannaa cauaod incraaaad weigh* loaaaa with llnaaad nil (and preauaably Ineraaaad hrinklag). Ihajr alaa ahewod that Co and Mo drlara lad ta cracking af ex pend llnaaad all fllaa (Indicating ahrlakage). In "rila romacloo, Ptopartlee, and Degradation" (Zntaraclanea - 1958) It waa chaw that pure ell fllaa ahrank aa auch aa 16 - 17* in IBO daya i|lig la tha laboratory. ana, than la canaldarabla evidence that yalnta ualng cobalt aa a drier Kill ahrlnk aora and will ba aora rigid than tbaaa nalng load. Adolttudly any palate an non fomilatod with cobale aa the prtaary driar. Int da m know what thalr affect baa baaa on old, waak paint fllaaT It nanld oeaa that a ceaearch prajact on load ahmld eanaldar tbaaa faetara. -3- 0007-SUP-037120 0007-SWP-000118412