Document 2qN2xw3am1YOyn228jNnwVDvp

March 5,2007 Via Electronic and U.S. Mail Richard Irons, PhD, DABT Principal Investigator, Shanghai Health Study University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Ralph J Altiere, PhD Dean, School of Pharmacy University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Re: The Shanghai Health Study Dear Drs. Irons and Altiere: We are writing on behalf of the the scientific and clinical research being We appreciate Dr. Shanghai and his previously (API) in support of '-HH"HE:,uU~ Health Study. January 29th SHS Oversight expressed for moving forward by Dr. Irons. party, requires a proposal consistent with its the urgency of this matter, and if we can assist in advise. API has been authorized to spend additional V'-'~HH"F,V"H upon API receiving formal financial members of the Benzene Health Research Consortium. the study being continued are the implementation of an acceptable independent Quality Assurance/Quality Control plan and acceptable metrics and milestones for progress and payment. API has considered the Draft request, Shanghai Health Study Proposed Budget for Extension and JCML Transition dated November 10, 2006, submitted by Dr. Irons of the University of Colorado. Additional funding up to $6,559,864 has been agreed to. This represents funding for the following (as described in the referenced request): 1 Plan A Study Completion Total (Tables I and 2) 1 $5,759,864 1 SHELL-MCCLURG-065191 Plan B Laboratory Transition Personnel Proposed Budget (From Table 3) $400,000 Post Study Costs for continued publication of study findings $400,000 TOTAL $625522864 Formal authorization and disbursement of these additional monies is contingent upon successful execution of an agreement between API and the research entity that will be continuing the study. Given the urgency to execute a grant/contract to forward to receiving a proposal in the near future to '-'LU''''',", establish a new contract with the University of entity. API Exhibits A-I to A-III, Proposal Guide For attached; the information requested therein is commitment. Sincerely, Red Cavaney SHELL-MCCLURG-065192