Document 2qLp08dprgnLo9v80k8zLDDwL

June 30, 1969 Mr. A. D. Florence Director of Plant Safety General Motors Corporation Chevrolet Division 1455 West Alexis Toledo, Ohio Dear Mr. Florence* Following your visit to St. Louis, I have been asked to forward toxicity Information on our Pfcdraul 312. The attached table shows comparative data for this pro duct and Pydraul A-200 which, X understand, you are familiar with* The animal toxicity data indicate that Pydraul 312 is Slightly more toxic when administered orally to rata but would still be considered"practically non-toxic" from the standpoint of accidental ingeatlon by humans. Pydraul 312 is significantly less toxic when applied to the skin of rabbits. The looal effect on the skin in terms of potential Irritation also Indicates the lower degree of hasard. The eye irritation potential la comparable as are the vapor inhalation data. Our label for Pydraul 312 is the same aa for Pydraul A-200 and la aa follows1 CAOTIOHl Contains Chlorinated Hydrocarbons. Avoid prolonged breathing of vapors or mists. Avoid contact with eyes or prolonged contact with skin. If skin contact occurs, remove by washing with soap and watar. Following eye contact flush with water. If clothing becomes soaked with fluid, launder before wearing again. Experience with the Pydraul series indicates that they should be used in a system aa free from leaks as possible. OSW 018646 STLCOPCB4005190 Hr. A. D, Florence June 30, 1969 Page Two This Is particularly Important If the fluid Is at ele vated temperatures where components of the formulations may be volatilised Into the work room. At ambient temp erature the vapor pressures are such that there la no significant vapor Inhalation hazard. We recommend the avoidance of repeated and prolonged skin contact principally because the fluids are good solvents for the natural oils and fats on the skin. The removal of these natural "barriers" can lead to drying and craoking. In summary, we believe that any precautions which have been taken to avoid exposure to Pydraul A-200 will suffice in avoiding any difficulties with Pydraul 312. Sincerely, KPWlj U Enclosure c.o. b.c. R. S. Fulton V. 3. Castrop Of. F. Fague N. T. Johnson R. A. Garcia Elmer P. Wheeler Manager, Environmental Health DSW 018647 STLCOPCB4005191 COMPARATIVE TQXXCITT OP PYDRAUL 312 AND PYDRAUL A-200 Pydraul .......... _ .312............. Oral LD50-Rats 6,500 mg/kg (5^60-7735) Skin MLD Rabbits 2,000-3,160 mg/kg Skin Irritation Rabbits Max. score after 1.3/8.0 24 hrs Eye irritation Rabbits Max. score after 13.0/110 24 hrs Vapor Inhala tion - rats Fatalities/no. exposed ' 0/4 Pydraul A-200 10,500 mg/kg (9295-11,865) 625-1,250 mg/kg 3.0/8.0 24 hrs 11.3/110 1 hr 0/4 Atmosphere saturated with vapors at ambient temperature DSW 018648 STLCOPCB4005192