Document 2qJ1gLbGGyLRKnv96OrbOXg6g

CHEMICALS 3 '0 INDUSTRIES INTEROFFICE X LAKE CHARLES TO Distribution FROM R. P. Lynci DATE SUBJECT April 22, 1974 VCM Tank Car Safety Meeting A review of the rulings and company reactions to these rulings was made in Philadelphia at the VCM tank car safety meeting. X was most impressed with the change in attitudes of most of the VC Poly people. They are doing most of the things that were impossible in February (by their words). The most important item was the mouse failure. A table of results shows this: Control Group 50 ppm VC* 200 ppm VC 2500 ppm VC Mice 15/5 31/9 //13 8/13 Mortality (M/F) Rates 4/4 10/8 6/9 5/7 Hamsters 13/22 20/20 2Z/29 27/27 VC was administered for 7 hours/day for 5 days/week. The rodents not fed anything and 100 of each sex were used. Control 50 ppm 200 ppm 2500 ppm Results of Autopsies Tumors Lung Angio - -" 4 22 6 34 19 17 17 Skin " 2 2 3 As may be readily seen these results will lead to some severe restrictions on VC. The existing temporary standard will probably not stand. It is hoped that 10 ppm will be tried. The mice test is equivalent to approximately 20 to 25 years for a human when the first angios were found. Moltoni is also finding tumors at low levels but his work is not released yet. (Most of the mortalities are from eating one another because of hunger.) BFG now has approximately ten cases. Only two or three died of angio but the others are reasonably real. Most of them had slides of biopsies that were checked for angio. Some of the deaths are back to 1969. Another important item was the nav 10 minute test. This has been very confusing. OSHA and NIOSH have both given and are using different times 1-3 hours. Basically they do not care about SL 091400