Document 2qBJy3bjom1pqjVo8Oe65rKNb

CENTSAt RESEARCH AND DEVELOPMENT DEPARTMENT HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE April 15, 1988 MEMORANDUM TO W. C. HAAF A, 0. HAY, M.D, S. G. HUNDLEY A. M. KAPLAN G. L. KENNEDY N. D. KRIVANEK L. 5, MULLIN C. F. REINHARDT, M.D A. M. SARRIF W, L. SPROUT, M.D. G. P. SYKES H. 0. TROCHIMOWICZ 3. F. VISKOCIL - ERD - ER - CR&D - CR&D - CR&D - CRl&O - CR&D - CR&D - CR&D - CR&D - CR&D - CR&D - CR&D N-11502-2 N-11400 HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY HASKELL LABORATORY FROM: R, C. GRAHAM, AEL COMMITTEE SECRETARY AEL COMMITTEE NOTES (Next Meeting - Wednesday May 11, 1988 - Haskell Laboratory Haskell Laboratory Room #619 Starting at 9:00 a.m. 1 Minutes of April 13, 1988 Meeting (a). Decision Items Carbitol Acetate (PP.D) 10 ppm (8- and 12-hour TWA). Chlorine (CAP) Dodecanedioic Acid (PPD) CEG * 0,05 ppm (24-hour TWA), 5 mg/m3 (8- and 12-hour TWA), respirable dust. 10 mg/m3 (8- and 12-hour TWA), total dust. CEG =0.5 mg/m3 (24-hour TWA), total dust. Formaldehyde (PPD) CEG = 0.2 ppm (24-hour TWA). Continued Discussion Items Lead (ESP.) Benzene (C&P) -- Dibasic Esters (Update Subcommittee) These items were continued. Benzene will be discussed at the May meeting. Dibasic Esters will be continued until ongoing, studies being conducted at Haskell are completed. Lead will'" be continued until an ongoing review of the extensive toxicity data base is completed. 2. Agenda for May 11, 1988 Meeting (a), Declsion Items C h 1 o r o p r ene (P P D) CEG = 0.5 ppm (24-hour TWA), Ethanolamine (PPD) CEG = 0.3 ppm (24-hour TWA). Fiber Glass (Fibers Subcommittee) AEL = 5 fibers/cc (8-hour TWA) , fibers > 5 microns long, < 5 microns in diameter, and with an aspect ratio of > 3:1. (b). Finalization Items Acrylonitrile (PPD) CEG = 20 ppb (24-hour TWA), 2-Ethylhexanol (PPD) Tetraethyleneglycol Diacrylate (ED) (c3. Piscussion items AEL = 20 ppm (8-hour TWA), AEL = 0.5 mg/m^ (8- and 12-hour TWA). Benzaldehyde (ED) Benzaldehyde has slight acute oral toxicity with an LD5Q in rats of 1300 mg/kg. Benzaldehyde was not a skin irritant or sensitizer when tested on the skin of guinea pigs. No deaths occurred in a group of six rats exposed to 1525 ppm of a benzaldehyde:Zany1 A {20;1) mixture. No adverse effects were observed in rats fed 10QQ or 10,000 ppm of benzaldehyde in their diet for up to 28 weeks. In a two-week inhalation study, no adverse effects were observed in rats exposed to 185 ppm of the benzaldehyde-Zonyl A mixture mentioned above, Benzaldehyde has 2 ppm [8-hour TWA) and 4 ppm (15-minute TWA) WEELs that were established in 1985, -4-r DUP040011192