Document 2q6ayQpan2zBo40RpjYay6QQ7

AM05H 3fr\|fD Lqy^ 0C0 IN D U STR IAL IiYCILNL I c ! < o I ooo o 'O I i ? James J. Hall (conoccp Date - Z_e-_ 'MJi_ fL~r^&v_y- X*aiKnc/ 7s '^J- Tut-e-f<*w/ ^ \tfu juor^'ts^ A^-e/lbids gJU* jmQMzlc/-zpze&yLc V sfutw' a-pi ^ -, VVC 000008972 NIOSH Manual of Analytical Methods Second Edition U. S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service Center for Disease Control National Institute for Occupational Safety anb Health VVC 000008973 CONTENTS OF VOLUME 1 Foreword ............................................................................................................... *`i Preface ................................................................................................................... v Abstract ........................--.................................................................................. v Acknowledgments .................................................................................................. xm PART I NIOSH Monitoring Methods P&CAM No. Lead in Blood and Urine ................................................................................... 102 Colorimetric Method for Free Silica .................................................................. 106 Antimony in Urine .............................................................................................. 107 Nitrogen Dioxide in Air ..................................................................................... 108 Free Silica (Quartz, Cristobalite, Tridymite) in Atmospheric Dust ................ 109 Quartz in Coal Dust by Infrared Spectroscopy ................................................ 110 Carbon Monoxide in Air ..................................................................................... 112 Carbon Monoxide in Blood ................................................................................. 113 Fluoride in Urine ................................................................................................ 114 Chloride in Air .................................................................................................... 115 Cyanide in Air .................................................................................................... 116 Fluoride and Hydrogen Fluoride in Air ............................................................ 117 Acrolein in Air .................................................................................................... 118 Beryllium in Air ................................................................................................- 121 Selenium in Urine ..................... 124 Formaldehyde in Air ............................................................................................ 125 Hydrogen Sulfide in Air ..................................................................................... 126 Organic Solvents in Air ..................................................................................... 127 Arsenic in Urine and Air ................................................................................... 139 Arsenic in Urine and Air..................................................................................... 140 2,4-Toluenediisocyanate (TDI) in Air .............................................................. 141 p.p-Diphenylmethanediisocyanate (MDI) in Air ................................................ 142 Mercury in Urine .................................................................................................. 145 Sulfur Dioxide in Air............................................................................................ 146 Total Particulate Chromium in Air.................................................................... 152 Ozone in Air ........................................................................................................ 153 Ozone in Air ........................................................................................................ 154 Parathion in Air .................................................................................................... 158 Oil Mist in Air...................................................................................................... 159 Sulfur Dioxide in Air .......................................................................................... 160 Sulfur Dioxide in Air .......................................................................................... 163 Mercury in Urine .............................................. 165 Mercury in Blood .................................................................................................. 167 Aromatic Amines in Air ..................................................................................... 168 Chromic Acid Mist in Air ................................................................................. 169 General Procedure for Metals ...................... 173 Mercury in Air .................................................................................................... 175 Tin in Atmospheric Particulate Matter and Biologic Materials ...................... 176 Gallium in Air ...................... 177 Vinyl Chloride in Air............................................................................................ 178 Carbon Disulfide in Air....................................................................................... 179 Arsenic in Air .................................................................................................... 180 ix VVC 000008974 Selenium in Air .................................................................................................... 181 Chromium in Air .................................................................................................. 182 Polynuclear Aromatic Compounds in Air .......................................................... 183 Polynuclear Aromatic Hydrocarbons in Air ...................................................... 184 Benzo(a)pyrene in Air.......................................................................................... 186 Sulfuric Acid Mist in Air ................................................................................... 187 Arsenic in Air ...................................................................................................... 188 Antimony in Air .................................................................................................. 189 Indium in Air ........................................................................................................ 190 Lead and Cadmium in Air ................................................................................. 191 Arsenic in Blood .................................................................................................. 192 Antimony in Blood .............................................................................................. 193 Indium in Blood .................................................................................................. 194 Lead in Blood .................................................................................................... 195 Arsenic in Urine .................................................................................................. 196 Antimony in Urine .............................................................................................. 197 Gallium in Urine .................................................................................................. 198 Indium in Urine .................................................................................................... 199 Lead in Urine ...................................................................................................... 200 Methyl Chloride in Air.......................................................................................... 201 Acrylonitrile in Air .............................................................................................. 202 Nitroglycerin and Ethylene Glycol Dinitrate (Nitroglycol) in Air .................... 203 Sulfur Dioxide in Air ........................................................................................... 204 Ammonia in Air.................................................................................................... 205 Total Particulate Aromatic Hydrocarbons (TPAH) in Air .............................. 206 Lead in Blood and Urine ................................................................................... 208 Free Chlorine in Air ....... 209 Acrolein in Air...................................................................................................... 211 Gaseous and Particulate Fluorides in Air............................................................ 212 Bis(chloromethyl) Ether in Air ........................................................................... 213 Lead , in Air or Blood ......................................................................................... 214 Inorganic Phosphate in Urine............................................................................... 215 Phosphoric Acid in Air ............................................................................. 216 Benzene-Soluble Compounds in Air .................................................................. 217 Phosgene in Air ........................................................................................... 219 Chloromethyl Methyl Ether and Bis(chloromethyl) Ether in Air .................. 220 Aliphatic Amines in Air .......... 221 Zinc Oxide in Air ....................................... 222 Cadmium in Blood .............................................................................................. 223 Cadmium in Urine ................................................................................................ 224 Kepone in Air........................................................................................................ 225 -2,6-Di-t-Butyl-p-Cresol (DBPC) in Air ................ 226 Polymethylsiloxane Mist in Air ......................................................................... 227 Thiram in Air ...................................................................................................... 228 Pentachlorophenol in Urine ............................................................................... 230 Nitrogen Dioxide and Nitric Oxide in Air ........................................................ 231 Formic Acid in Air ............................................................................................ 232 Diazonium Salts and Azo Dyes in Air ....................... .................................... 234 Formaldehyde in Air .................... 235 4,4'-Methylenebi$(2-chloroaniline) in Air .......................................................... 236 Procedure for the Preparation of Tissue for Analysis ..................................... 237 x VVC 000008975 Asbestos Fiber in Air ......................................................................................... 239 Sodium Hydroxide in Air..................................................................................... 241 Phosphorous in Air .............................................................................................. 242 Benzidine in Air.................................................................................................... 243 Polychlorinated Biphenyls (PCB) in Air............................................................ 244 Chrysotile Asbestos in Bulk Samples .............................................................. 245 3,3'-Dichlorobenzidine in Air.................................................................... -........ 246 Methyl Alcohol in Air.......................................................................................... 247 Hydrazine Compounds in Air ............................................................................. 248 Benzo(a)Pyrene in Particulates ........................................................................... 251 N-Nitrosodimethylamine in Air........................................................................... 252 Polychlorinated Biphenyls (PCB) in Air ............................................................ 253 Thiophene in Air .................................................................................................. 255 Azelaic Acid in Air ............................................................................................ 256 Phosphorous (white) in Air ................................................................................. 257 Free Silica (Quartz, Crystobalite, Tridymite) in Airborne Dust...................... 259 Lead in Blood and Urine...................................................................................... 262 Index xi vvc 000008976 CONTENTS OF VOLUME 2 PART II Standards Completion Program Validated Methods Acetone ................................................................................................................ Antimony and compounds (as Sb)......................................................................... 2-Butanone ........................................................................................................... Hydrogen sulfide................................................................................................... Manganese and compounds (as Mn) ............................................................... Ozone .................................................................................................................... Camphor................................................................................................................ Mesityl oxide ................................................. 5-Methyl-3-heptanone ........................................................................................ Methyl (n-amyl) ketone ...................................................................................... Ethyl butyl ketone .............................................................................................. Hexone ..................................-.............................................................................. Cyclohexanone ....................................................................................... ............. 2-Pentanone ......................................................................................................... p-tert-Butylcoluene ............................................................................................... Cumene ................................................................................................................ Vinyl toluene ....................................................................................................... alpha-Methyl styrene .......................................................................................... Terphenyls ........................................................................................................... Cyclohexane ......................................................................................................... Ethyl benzene............................................................................................. Styrene .................................................................................................................. sec-Amyl acetate.............................................................. :................................... tert-Butyl acetate ................................................................................................. Dibutyl phthalate ................................................................................................. Ethyl acrylate ....................................................................................................... Ethyl formate ....................................................................................................... Methyl isoamyl acetate.......................................................................................... Methyl acrylate .................................................................................................. Methyl cellosolve acetate .................................................................................. Di-2-Ethylhexyl phthalate.................................................................................... 2-Ethoxyethyl acetate ........................................................................................ Methyl acetate ..................................................................................................... Isobutyl acetate .................................................................................................. Isoamyl acetate .................................................................................................. sec-Butyl acetate ................................................................................................ Butyl acetate .................................................................................. n-Propyl acetate ......................................... Ethyl acetate......................................................................................................... Isopropyl acetate ................................................................................................ n-Amyl acetate..................................................................................................... Allyl alcohol ......................................................................................................... sec-Butyl alcohol ................................................................................................ Cyclohexanol .....................................................................;................................ Diacetone alcohol ........... Ethyl alcohol ....................................................................................................... Hydroquinone ...................................................................................................... SI S2 S3 S4 S5 S8 S10 S12 SI3 S15 SI6 SIS S19 S20 S22 S23 S25 S26 S27 S28 S29 S30 S31 S32 S33 S35 S3 6 S37 S38 S39 S40 S41 S42 S44 S45 S46 S47 S48 S49 S50 S51 S52 S53 S54 S55 S56 S57 ' iii VVC 000008977 Isoamyl alcohol .................................................................................................. *S5.8 Methyl alcohol .................................................................................................... S59 Methyl isobutyl carbinol .................................................................................... S60 Propyl alcohol .................................................................................................... S62 tert-Butyl alcohol.......................................................................................................S63 Isobutyl alcohol ........ S64 Isopropyl alcohol ................................................................................................ S65 Butyl alcohol ....................................................................................................... S66 Chlorinated camphene ........................................................................................ S67 Dipropylene glycol methyl ether ....................................................................... S69 Glycidol ............................................................................................................... S70 Methylal ............................................................................................................... S71 Phenyl ether ......................................................................................................... S72 Phenyl ether-Biphenyl mixture (vapor) .......................... S73 Phenyl glycidyl ether ................ S74 Propylene oxide .................................................................................................. S75 2-Butoxy ethanol ............................................................................................... S76 Isopropyl glycidyl ether ...................................................................................... S77 Tetrahydrofuran .................................................................................................. S78 Methyl cellosolve ................................................................................................ S79 Ethyl ether ........................................................................................................... S80 n-Butyl glycidyl ether ........................................................................................ S81 Cyclohexene ....... S82 Naphtha, coal tar ................................................................................................ S86 Propane ............................................................................................................... S87 Turpentine ........................................................................................................... S88 Heptane ............................................................................................................... S89 Hexane ................................................................................................................. S90 Butadiene ............................................................................................................. S91 Ketene ................................................................................................................. S92 LPG (Liquified petroleum gas) ......................................................................... S93 Methylcyclohexane .............................................................................................. S94 Propylene dichloride............................................................................................ S95 Pentachloronaphthalene ...................................................................................... S96 Octachloronaphthalene ........................................................................................ S97 Methyl iodide ....................................................................................................... S98 Hexachloronaphthalene ...................................................................................... SI00 Hexachloroethane ................................................................................................ S101 Fluorotrichloromethane ..................................................................................... SI02 Ethylene chlorohydrin ........................................................................................ Si03 Ethylene dibromide ............................................................................................ S104 Ethyl bromide .................................................................................................... SI06 Difluorodibromomethane .................................................................................... S107 Dichlorotetrafluoroethane .................................................................................... S108 Dichloromonofluoromethane............................................................................... S109 1,2-Dichloroethylene .......................................................................................... SI 10 Dichlorodifiuoromethane .................................................................................... Sill Chloroprene ....................................... SI 12 Chlorobromomethane ................ Si 13 Bromoform ........................................................................................................... SI 14 Benzyl chloride..................................................................................................... SI 15 IV VVC 000006978 Allyl chloride ...................................... Acetylene tetrabromide....................... Epichlorohydrin .................................. Chlorinated diphenyl oxide.... ............ Chlorodiphenyl, 54% chlorine ........ Ethylene dichloride ........................... 1,1-Dichloroethane ............................. 1.1.2.2- Tetrachloroethane................ Trifluoromonobromomethane ............. 1,2,3-Trichloropropane....................... Trichloronaphthalene ......................... 1.1.2- TrichIoro-lt2,2-trifluoroethane . Tetrachloronaphthalene ..................... 1.1.1.2- Tetrachloro-2,2-difluoroethane 1 tl,2,2-Tetrachloro-l ,2-difluoroethane Chlorobenzene .................................... 1.1.2- Trichloroethane ................... Index .. S116 - SI 17 .. SI 18 .. SI 19 .. S121 . S122 .. S123 .. S124 .. S125 .. S126 .. S128 .. S129 .. S130 .. S131 .. S132 .. SI33 .. S134 v VVC 000008979 CONTENTS OF VOLUME 3 PART n Standards Completion Program Validated Methods o-Dichlorobenzene .............................................................................................. SI35 Diazomethane ................. S137 Diethylamine .................................................................................. ................... SI39 Dimethylamine .................................................................................................... SI42 1.1- DimethyIhydrazine ................................... -............................................... S143 Ethylamine .......................................................................................................... SI44 N-Ethylmorpholine .............................................................................................. SI 46 Isopropylamine .................................................................................................... S147 Monomethyl hydrazine ....................................................................................... SI49 Morpholine .......................................................................................................... SI50 Triethylamine ...................................................................................................... S152 Monomethyl aniline ............................................................................................ SI53 Tetramethyl succinonitrile ................................................................................. SI55 Acrylonitrile ........................................................................................................ SI56 Phenylhydrazine .................................................................................................. SI60 Pyridine .............................................................................................................. SI61 Xylidine .............................. ............................................................................... SI62 Dimethylaniline.................................................................................................... SI 64 Acetonitrile .......................................................................................................... SI65 Cresol, all isomers .............................................................................................. S167 o-Toluidine .......................................................................................................... SI 68 Acetic anhydride ................................................................................................ SI70 Sulfuric acid ........................................................................................................ S174 Hydrogen bromide .............................................................................................. S175 Hydrogen fluoride ................................................................................................ S176 2-Hexanone ........................................................................................................ S178 Phthalic anhydride .............;............................................................................... SI79 Tin, inorganic compounds, except oxides.......................................................... SI 83 Zirconium compounds (as Zr) ................................. S185 Copper, dusts and mists..................................................................................... Si 86 Tellurium hexafluoride ....................................................................................... SI 87 Rhodium, metal fume and dust........................................................................... SI 88 Rhodium, soluble salts ....................................................................................... S189 Selenium compounds (as Se) ............................................................................. S190 Platinum, soluble salts (as Pt) ........................................................................... S191 Molybdenum, soluble compounds .................................................................... SI93 Barium, soluble compounds ............................. S198 Yttrium ................................................................................................................ S200 Tellurium ...................... S204 Calcium oxide...................................................................................................... S205 Nickel, metal and soluble compounds (as Ni).................................................... S206 Tributyl phosphate ............................................................................................. S208 Triorthocresyl phosphate ................................................................................... S209 Triphenyl phosphate ......... .;v............................................................................ S210 1.1- Dichloro-l-nitroethane ............................................................................... S213 Ethylene glycol dinitrate/'Nitroglycerin ................................ S216 Nitrobenzene ...................................................................................................... S217 iii VVC 000008980 p-Nitrochlorobenzene .......................................................................................... S218 Nitrotoluene ......................................................................................................... S223 Tetranitromethane .............................................................................................. S224 Tetryl (2,4,6-Trinitrophenylmethylnitramine) .................................................. S225 n-Propylnitrate ............. S227 Arsine .................-....... ......................................................................................... S229 Hydrazine ........................................ -................................................................... S237 Hydrogen chloride .............................................................................................. S246 Carbon disulfide .................................................................. .....---....... --........ S248 Carbon dioxide .................................................................................................... S249 Cyanide (as CN) .................................................................................................. S250 Dimethyl acetamide ............................................................................................ S254 Dimethyl formamide............................................................................................ S255 Carbon black ...................................................................................................... S262 Ethyl silicate ................................................ S264 Oil mist, mineral.................................................................................................. S272 Carbaryl ...................... S273 DDT ................................................................................................................... S274 Aldrin ................................................................................................................. S275 p-Dichlorobenzene .............................................................................................. S281 Dieldrin ................................................ S283 EPN (O-Eihyl-O-p-nitrophcnyl phenylphosphonothiolaic) ............................ S285 Ethylene oxide .................................................................................................... S286 Lindane ............................................................................................................... S290 Naphthalene ........................................................................................................ S292 Nicotine .......................................... S293 Parathion ............................................................................................................. S295 Thallium, soluble compounds (as Tl) ................................................................ S306 Arsenic and compounds (asAs) .......................................................................... S309 Aniline ................................................................................................................. S310 Benzene .............................................................................................................. S311 Cadmium dust ............................................................................................ S312 Cadmium fume .................................................................................................. S313 Carbon tetrachloride........................................................................................... S314 Silica, crystalline .................................................................................................. S315 Chromic acid and chromates ............................................................................. S317 Xylene ................................................................................................................ S318 Chromium, soluble chromicand chromous salts (as Cr) ................................. S323 Methyl chloroform ........ S328 Methylene chloride ........................................................................................... S329 Phenol -............................................................................................................... S330 Phosphoric acid ..................................................... S333 Tetrachloroelhylene ........................................................................................... S335 Trichloroethylene ................................................................................................ S336 Beryllium and berylliumcompounds (as Be) ................................................... S339 Lead and inorganic lead compounds .......................-....................................... S341 Toluene .............................................................................................................. S343 Boron oxide ........................................................................................................ S349 Chloroform ...............................v......................................................................... S351 Chromium, metal and insoluble compounds........................................................ S352 Dichloroethyl ether.............................................................................................. S357 iv VVC 00000B981 Diisobutyl ketone ................................................................................................ S358 Dioxane ..................................................................-............................................................... S3 60 Isophoione ............................................................................................................................. S367 Isopropyl ether .................................................................................................... S368 Magnesium oxide fume .................................................................................................... S3 69 Malathion ............................................................................................................ S370 Methyl bromide .................................................................................................. S372 Molybdenum, insoluble compounds .............................................................................. S376 Octane ................................................................................................................. S378 Pentane .......................................-....................................................................... S379 Petroleum distillates ........................................................................................... S380 Stoddard solvent.................................................................................................. S382 Titanium dioxide ............................................................................................... S385 Vanadium, V205 dust......................................................................................... S391 Index v VVC 000008902