Document 2q2ezrDdOEyojYo5M9EXq77YN

FILE NAME: WR Grace (WRG) DATE: Unknown DOC#: WRG229 DOCUMENT DESCRIPTION: 0000 Outline for Asbestos and Human Health. Incomplete document. u .c , -- ber/.e V'.. . l i n ;' - - P*LL` L>d'-> . >.\J 4c . / \ X . a b e s c o s i s ppne. r i c Cer:.; f o r a " . r e a p - S Ok *. k G w0 G O r .7 , F e , Xa , n d / o r c. 0 4*1 .4. P d d G e . - G G d d ; P. C CG PP .. C , . J . . U . b l MJ !\C CO CP, c a r i c a i a c c i n - ' ' V . _ . a j o r Cy X*. s o f ;i s !;p s t o s -C> tN*- .i d G A . Cn. r y s o t oc v o r le. p r o c u c c i e n . U* OC 4MVl i t e ( c . ' `C a p e b l u e " ) C. . S 1 JP S . .V.'vwho;,\\ J k k k i- N.. * " T r c " . o l i k.P c r i d 'P 1 VU C c i o n o f a s b e s C o s ( c o n s ) 13 o 0 1C00 1V- k /-.r ', s"> 1930 1950 1S0 *,Vo G 500 35,OC0 200,000 o 0 0 1,300,000 2,300,000 ^TjO^'jjOwO u*. u S Oc j r Os Cr.i.ien c proc.ucrs\,pipes, s '.cc. e s , s h i n x l e s ) A spha 1i and vinyl asbestos floor ci le ; v S - C 3 " OS d ; GP 'C 3 i k loafin'; frics LroNc. linings C^ i. ;C1rVHJ CO!., y d i P,GS Insule, fin-'; nstcrinlsCpipe and boiler coverings, ccc. ) Spray asbestos Filters Sus;>ccrcd or proven effects en lionIth sbe s te s i s ( a s b e s to s pr.eunoconi osi s) s . s r o r . c h o . v o r . i c c a r c i n o s : Pi V X e s o t h e l i ^ l r ia r o r s o r p l e u r a and p e rito n e u ir. J t Terrors of che R a stro i n r c a c m a l ef o c c x i lV-\ i i iv: A best(>r. cl human i.r.iifh (continued) Asbor.roiU s A , chronology 1900 -- First case < 1907 -- Above ca.se ' -i.,VO / 0;tirer cases ccd by Cooler 1930 -- verevctr.tr 1 1 / r \ *7 t / . Oritish 1933 -- U.S.Oublie , set uno industr 1963 -- Lea chart in of asbestosis in insulation workers; confirmed in bn y Area 1964-1965. ' same 3. Salient features 1. Pathologic charmes: fibrosis around respiratory bronchioles and alveolar ducts; fibrosis of pleura; calcification of pleura; ''asbestos" bodies; 2. Functional: reduced compliance, diminished VC ana impaired diffusing capacity; increased pulmonary artery pressure, cor puir, 3. Time to develop: heavy exposures 5-10 years; present levels of exposure: 20-30 years. C. Outstanding current problems 1. Relationship between dose and response: what is safe level? 2. Different effects of different types of abbescos 3. Importance of pulmonary arterial effects 4. Frequency of delayed effects from early heavy exposures. . II. Association of asbestos and lung cancer A. Chronology 1935 -- Lynch < Smith reported single case in Sout.> rOl i.a* 1947 -- Merowether in l:k stated 31 of 23 5( 13.2'/, cf certified cases of asbestosis 1924-46 died of cancer of iune; contrasted with 1.34 of ,434 cases of silicosis. - 1955 -- Doll studied 105 men who had worked 20 or more years with asbestos, concluded lung canccfrrisic 1C x that of general population 1958 -- 3raun n Truan studied Quebec asbestos miners and mill workers; found no significant excess. 1959 -- VcCullouph updated L'h study 63/365 asbestosis cases had died of lung cancer 1903 -- Mancuso studied cohort of 1,495 workers in asbestos products plant in 1535-39 using. Social security records Thru i960, lung cancer deaths were 3 x expected. 1963 -- Selikoff ff ouncl lung cancer deaths in FT and i.'J insulate in trade 20 years of more 6,6 times expected. 1964 -- Dunn found lung cancer deaths 3 x expected in California insulators. 1968 -- Cooper et al found 8 x expected in Day Area insulators. * 1. L-j\.V1' .w ya.w o*14*ei'*o 2. C - U typos ;iOu c.ifi.eyenc fro 3. .-.pparcat sy N ^ ... ,M,Jt.U-. C-4x U_ w V*>v><tOn44 ^tH' Waor3 of cl1fioroni; bypoo of asbestos *'%0 i>c O *. j ^"*o :ctnis and hydro carbono-- ia asbestos merely a car. io;:? oec t-1>o o ork^'w fcOitiwiUiioiipo asbestos v/ith mesothelioma of pleura and peritoneum .1 . e erano.o-y 1546 -- 1'Ayers reported mescthel ini tumor in thesis Icichar reported p>eri`concai mesothelioma tornar ropo roed 4 tumors in 72 canon of asbestosis kvcj ---- .ve. re /le.,eu 13 cicuens ir London iawo...on vita anoeotcsia and found that 0 had had ovarian or peritoneal cancer LCcw ---- Lryner, S^cycs and arenano reporoeu ot Gicruae m e s m e liomats i.; oo.Ar.eav,..' Capy in crocxdoiitc arem , lvo2 "- XcC;. ..yr.ey > O.j, OS oc. oou.es v.cc* i.o;ne ia aoc cm and 9 had vrorhc; zCt ; py. u COb o IT a 19 3 - ' -4 , ; i . . W- W -- A -xW rcp_ vecs*-o o p_ .curai nosGunoiiora-a in *.I moulaar3 o^ra 19le ---- art iaUr.up ana smith reported 11 diffuse abdominal tumors associated ivith asbestos exposures 1965 -- lines .nd dado expanded scrics(of McCau^hoy) to 45; 32 V i t ` *. J O " "iyht or heavy exposure to asbestos iv65 ---- Tacos e .`.ncv^c.i reportca 6 pleural tumors in Dresden asbestos u'orxcrs 1935 -* Oman rerienod 17 pleural mesothelioma in Liverpool; 12 had te wC i i ' u 1 1' I ul V JkvC'.* cO S wC 3 v. 0 D Ip o 5 ---- SaihOit ct al, revcou-cd t,5u0 autoesiesj found 26 cases o; ssbestosis, L in these 4 pleural and 3 paritene;: 1 inV L w tei tU A. S. found ; rev:c-,/ir.p API? files, 45 mesotheliomata. In 307 asbestos vorxer deaths (over 20 yrs in trade), 10 mesothelioma. In 31,052 deaths in AGO study, 3 pleural mososae1lunata. 1906 -- Pevhousc and Phompscn old matched case study in London; 51 of 70 uosothclcornata had some history of asbestos exposure. 1967 -- Lie;ber., arci i'iatavica report 42 cases in Penney irania. P O %* * cm* icrturcj 1j 1*' o~ *3 icu t Latent periods vary lonn(2Q-4Q-years) Usual c.uestiens regardir.j rolo of co-factors and dosc-rcspon C l u C>lO itw * * p w I \;ith tuners of the C l tra c t '* C 1 Vi*\*'.C..'.*''*o -*Zw- '' / la., x.v;- l U c jT;.-'oi*uwv., -0 gcciwmS rtorx cancer CG iG.1 Cl 10 ycr.rt '".CvZ'-i"'. in I co.*>rc o*.' irGulc.ti*r.^ a 0v".Su I u*...i*.i ij Cw.*p%.**. c* w*.u*t O/.p*jC--GG G*. ***j ^ / a >OCtcC( to Gastric oc.r.cur obs/cx:> 12/4.3; colon or rector:. 17,^5, . .. v V'k*U k O t*. *v* -/ ** ^j i L, 0 fc wO *-i A 1^ t i i u C u i . kl >J 4 . 4 4* . C C .u V>>4a w . v%*'*. / --. U. *.0 %*. cl 4> 1 _,*4 C <^/C am XIX u j i l c u c O a V>C / t * 1 0 '<V4 a O* J j C k IC C **OVi S i i O V j C G lx p o i^ c G CO i a f GX p G C UCd * iawlICTkc ZCCtUPCJ . Irisuff ici>-*Vc data Co bi^in defining role of asbestos typo co-factors, or dosage relationships. :he "a sbe stos body" it w/U IS-7 1029 i'.Oi 193 *Vn J; Jc `ZV Va*i -- - COOXO '.I /-}-. -;cr.*!\w_Mw d bT/t **<-*rchar.il ir. F ra~i cc illcd co;.tec *.a.t j Ca.5 W l4. lots ; _lWS,.W*.L %**Cl X--UuOr,; SeeyCG ted tGI*7.1 1`asbes C03 is -- .c GO or.ted by oth or fi era U5 * -- 'd !'pr.cur.:a CdiIG3 IG body*1 Csuyh attested 1(r,inert 1-fibro body" -~ Crete suscosted "iferrusinous body" jOdies. 1931 S..r.aon are strschan reported m 4S of oO asbestos wor.ccrs'tputurr. recorded at indo:-: of exposure-, not of disease. 963 -- .965 ,965 -- .965 - ,966 - .9 GO - .vuu - .966 -- ,968 .969 14.%/ i P. VJW . i .i ri c, t <-/ ., %. : --- ,. i. - .% ,. i ,.... A-- 4. O VA. W* w 43 , *~T/ a. G C w I a. 4 - t . *c O J<.> y A A4_ k xxc itive Ls*le A: m j. .o *u,>ci 2/, Xi. isburpn, only 5% bad -any. Vb*'b' r repor-cu s9.u/. -- n> iPite.ur,^. Xcu: n repored 57.6% of 234 + in Finland; 6.47. had A_\r^.ilvel reported 43.c7 in Montreal, 47 had many, Covou;per et ai found 427. -- in Sar. Francisco, Gibh.oa;xsi at ai reported 547. of non and 447 of wor.cn in Milan scri; Gu-I < u.,,oous ki aor.ov .lo cpo.L*d 3 /.. t x.l * ..juu.y.ij ^***^ O I/'CCC 1GTl l.CC.'--X1CUO . c . ' ft ct ai report iittlo increase since 1934, more found in blue-collar than white collar workers. :e os ss. :oa as central fiber difficult, conflicting 2. reports frcr. rittaburph and New York studies Most positive cases have very few dobruXinous bodies 3. Sources and significance unclear.