Document 2jy9anO4qEqJdv37EL817vb5g

Principal F.Dr . J o s e ph Ca l l a h a n CHATHAM JUNIOR HIGH SCHOOL , CHATHAM, NEW JERSEY Te l e ph o n e Me r c u r y 5-9100 January 15, 1962 Roc-art A. K e h o s , K . D . , D i r e c t o r K ettering Laboratory, Eden and Be t h e s d a C in c i n n a t i , Ohio ' Dear Dr. Kehoe: Vfhile r e a d i n g an a r t i c l e about lead, n o is o n in g in th e Ja n - u a r y , 1962, i s s u e o f t h e m a g a z i n e , Today*s H e a l t h , I came a c r o s s s e v e ra l re fe re n c e s to the work done a t K e tte r in g L aboratory to a n a l y t i c a l l y d e t e c t t r a c e s o f le a d in th e body. The a u th o r o f the a r t i c l e , a Dr. John E. A llen, p a r t i c u l a r l y p ra is e d your con tributions in this area. . The a f o r e m e n t i o n e d a r t i c l e was b r o u g h t t o my a t t e n t i o n b y . an i n q u i s i t i v e f o u r t e e n - y e a r o l d s c i e n c e s t u d e n t o f mine who was s t i m u l a t e d t o do an e x p e r im e n t on mice t o n o t e some o f th e e f f e c t s o f l e a d p o i s o n i n g . - S in c e I am n o t w e l l g r o u n d e d ' i n t h i s s p e c i f i c a r e a , we j o i n t l y d e c i d e d t o l e a r n more a b o u t t h e t o p i c t o d e t e r mine the f e a s i b i l i t y of pursuing t h is experim ent, k e e p in g .forem ost in mind th a t the liv e s o f the experim ental animals must not be jeopardised. . I would v e ry much a p p r e c i a t e y o u r a d v i c e . L i s t e d below u n d e r column A a r e some c o n s i d e r a t i o n s we w i s h t o i n v e s t i g a t e . Column B l i s t s th e means b y w h i c h we h o p e t o o b t a i n t h e n e e d e d i n f o r m a t i o n . I f you w i l l be so k i n d a s t o e v a l u a t e t h e s e s t e p s and add su g g estio n s, you would be most h e lp fu l. Column A 1 . how to d e t e c t t h e p r e s e n c e and amount o f Pb nig m en t in paint 2. f i n d o u t the amount o f Pb which, i f administered to mice in the form of p a in t scratiings in th e ir food would be s u b -le th a l Qolnrrn B 1. w rite to the Rational P a in t, V arnish, and Lacquer A s s o c ia tio n , I n c . , 1500 Rhode I s l a n d Ave. , IT.'Y. , Washington 5, D.C. . 2. ? : perhaps th is in fo r mation can be obtained from C ib a .Pharmac e u ti c a l Products, Inc. KZ 0020267 Principal Da, F.J o s e ph Ca l l a h a n CHATHAM JUNIOR HIGH SCHOOL CHATHAM, NEW JERSEY (2) Te l e ph o n e Me r c u r y 5-9100 CP i m m A 5. how to perform, l a b o r a t o r y t e s t s on b lo o d a n d /o r u r i n e to o b ta in evidence (other than 0. e x te r n a l symptoms) o f ab n o r m a l c o n c e n t r a t i o n s , o f Pb a. , w h a t ;i s the t e s t a g e n t u s e d '.In tbs. sample sc re e n in g t e s t , and where can i t be obtained? b. is the ether used (CgHjj-JpO o r a n o t h e r e t h e r ? c. what volume of u rin e is required? 4. learn "de-leading" techniques 4. a. what s p e c i f i c compounds and in what q u a n tity can . be used as cle an sin g enemas to 'a s - l e a d ' the mi. c s b. can the drug, edathsir.il . c a l c i ton d i s o d i n n ( EDTA} be obtained fo r in lection? i f so, whore can i t be . obtained, what quantity . need be purchased., v/hat is tbs c o st involved, and w ill specific directions be included to explain how to i n j e c t the an im als (subcu tan.sou s , in traver.ous, or in muscle)? C-o..l-u-.m. n B 'c o g n iz a n t o f our l a c k of su itab le , equipment and t e c h n i q u e s , we hope t o d u p lic a te the. sample screening te s t which do c t o r s cs n n er form by adding a few drops of a te s t agent into a urine s p e c i m e n , add some CThCOOH and EuOp , an d t h e n acid a s m a l l `'amount o f o t h e r a. perhaps the lo c a l b . w hysician s can c. sum' ly t h i s in fo rm a tic ? : perhaps th is information can be obtained from Ciba Fharnac exit!cal Froduc t s , Inc . . As y o u c a n - g a t h e r f r o m t h e a b o v e l i s t i n g s , a t p r e s e n t we la c k much in fo rm a tio n needed b e fo r e u n d e rta k in g the ex p erim en t. The s t u d e n t i s a n x io u s and I m ight add, q u i t e a b l e , to ta c k le this project. ) Any i n f o r m a t i o n t h a t you can f o r w a r d t o u s w i l l b e g r a t e fu lly received. Very t r u 1y your s , k ? 0020268 ? . . '.-C .. i i,-. n . Gertrude k. Clarke (hiss) 9 th . Grade Science Teacher