Document 2jdMv1Xrv52vdyoOXgJNvGrJR

CHEMICAL MANUFACTURERS ASSOCIATION February 25, 1987 TO: IARC PROJECT PARTICIPANTS FROM: Nancy G, Doerrer Associate Director Health, Safety and Chemical Regulations SUBJECT: Draft IARC Working Papers: March 1987 Monograph Meetings Attached for your review are draft working papers from IARC on the chemical(s) for which you recently submitted summaries and bibliographies. These working papers will be used by the IARC Committee when they meet in Lyon, France, from 10-18 March 1987 to evaluate the carcinogenicity of these chemicals to humans. A summary table on genetic activity for your chemical(s) has been included (if available) with the IARC materials. This table is the outcome of the December 1986 IARC Monograph meetings. Also attached are four appendices that list chemicals with differing degrees of evidence for carcinogenicity in experimental animals. These chemicals were not part of IARC's original list to be considered in March 1987, yet have now been designated for carcinogenic evaluation at the upcoming meetings. If you have a specific concern about any of these added chemicals, or the one(s) for which you submitted information to CMA in recent months, please contact the CNA Observer to the March 1987 IARC Monograph Meetings at the address or phone number below: Robert J. Moolenaar, Ph.D. Dow Chemical Company 1803 Building Midland, MI 48640 517/636-0655 Please feel free to contact me at 202/887-1282 if you have any questions. Attachments cc: R.J. Moolenaar, Dow Chemical Company D. Matheson, Stauffer Chemical Company R.P. Schumacher, CMA G. Williamson, CMA OLI 4097 Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 2501 M Street, NW Washington. DC 20037 Telephone 202/887-1100 Telex 89617 (CMA WSH)  CHEMICAL MANUFACTURERS ASSOCIATION February 25, 1987 TO: IARC PROJECT PARTICIPANTS FROM: Nar.cy G. Doerrer Associate Director Health, Safety and Chemical Regulations SUBJECT: Draft IARC Working Papers: March 1987 Monograph Meetings Attached for your review are draft working papers from IARC on the chemical(s) for which you recently submitted summaries and bibliographies. These working papers will be used by the IARC Committee when they meet in Lyon, France, from 10-18 March 1987 to evaluate the carcinogenicity of these chemicals to humans. A summary table on genetic activity for your chemical(s) has been included (if available) with the IARC materials. This table is the outcome of the December 1986 IARC Monograph meetings. Also attached are four appendices that list chemicals with differing degrees of evidence for carcinogenicity in experimental animals. These chemicals were not part of IARC's original list to be considered in March 1987, yet have now been designated for carcinogenic evaluation at the upcoming meetings. If you have a specific concern about any of these added chemicals, or the one(s) for which you submitted information to CMA in recent months, please contact the CNA Observer to the March 1987 IARC Monograph Meetings at the address or phone number below: Robert J. Moolenaar, Ph.D. Dow Chemical Company 1803 Building Midland, MI 48640 517/636-0655 Please feel free to contact me at 202/887-1282 if you have any questions. Attachments cc: R.J. Moolenaar, Dow Chemical Company D. Matheson, Stauffer.Chemical Company R.P. Schumacher, CMA G. Williamson, CMA OLI 4098 Formerly Manufacturing Chemists Association--Serving ihe Chemical Industry Since 1872. 2501 M Street. NW Washington, DC 20037 Telephone 202/887-1100 Telex 89617 (CMA WSH) Pis tefkgf CHEMICAL MANUFACTURERS ASSOCIATION f April 2, 1987 aJ^x ^ ^ < Toxicologists Work Group Dr. Harry Skalsky FROM: Dr. Joseph McDade, Leader Ann M. Mason, staff SUBJECT: Carcinogenic Constituents List Our next assignment has arrived! In mid-Apr Protection Agency expects to publish a massive pr< regulating the burning of hazardous wastes as fue One integral portion of this rule is the proposed^ health values addressing both carcinogenic constituents. A 86 threshold constii list of these 134 c< *|"7- as Appendix A & B. These two lists, reportedly, i constituents and levels as they will appear in th py The values shown in both of these lists are 1 undisclosed method. Hopefully, an examination of background document addressing human risk will ide background document will be sent to you as soon as n can De pnotocopied. In the meantime, please examine the list of chemicals. To assist our comment organization, we have identified companies with each chemical based on data available in SRI Chemical Producers Index: Exhibit 1 (Appendix A constituents); Exhibit 2 (Appendix B constituents).. We realize that this may not accurately reflect the current production at some company operations. Each member is asked to examine the list and call Ann Mason or Marci Siegel with a list of those chemicals on which you will comment voluntarily. Please call Ann or Marci by April 10. From this list, we will send you any additional documents we get relating to the specific chemical. fT 7 Our first meeting has been set for May 5, 1987, at CMA. Please plan to attend. If you cannot attend, please send an alternate company representative who can express your company's position. With any luck and with your cooperation, hopefully, we can complete our assigned task on schedule. In the past the Office of Solid Waste has not yielded from the OLI 4099 Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 2501 M Street. NW Washington. DC 20037 Telephone 202/887-1100 Telex 89617 (CMA WSH) w Z& U/ ^4* pis Kf CHEMICAL MANUFACTURERS ASSOCIATION ? ^ r April 2, 1987 V> (Li. TO: Toxicologists Work Group Dr. Harry Skalsky FROM: Dr. Joseph McDade, Leader Arm M. Mason, staff SUBJECT: Carcinogenic Constituents List <+/4/?7 Our next assignment has arrived! In mid-April, the Environmental Protection Agency expects to publish a massive proposed rulemaking regulating the burning of hazardous wastes as fuel in industrial boilers. One integral portion of this rule is the proposed variance based on human health values addressing both 86 threshold constituents and 48 carcinogenic constituents. A list of these 134 constituents is included as Appendix A & B. These two lists, reportedly, represent the list of constituents and levels as they will appear in the Federal Register. The values shown in both of these lists are based on an, as yet, undisclosed method. Hopefully, an examination of the portion of the background document addressing human risk will identify EPA's method. The background document will be sent to you as soon as it can be photocopied. In the meantime, please examine the list of chemicals. To assist our comment organization, we have identified companies with each chemical based on data available in SRI Chemical Producers Index: Exhibit 1 (Appendix A constituents); Exhibit 2 (Appendix B constituents).. We realize that this may not accurately reflect the current production at some company operations. Each member is asked to examine the list and call Ann Mason or Marci Siegel with a list of those chemicals on which you will comment voluntarily. Please call Ann or Marci by April 10. From this list, we will send you any additional documents we get relating to the specific chemical. /VW ^ . .^ -7 Our first meeting has been set for May 5, 1987, at CMA. Please plan to attend. If you cannot attend, please send an alternate company representative who can express your company's position. With any luck and , with your cooperation, hopefully, we can complete our assigned task on schedule. In the past the Office of Solid Waste has not yielded from the OLI 4100 Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 2501 M Street. NW Washington, DC 20037 Telephone 202/887-1100 Telex 89617 (CMA WSH) comment date. We cannot, and should not, count on any more than 60 days to review the appropriate documents and reply to EPA. Joining us in our effort will be Neil King, as external legal counsel, and a consultant toxicologist. We at CMA look forward to working with you. Please call Marci Siegel (202-887-1175) or Ann Mason (202-887-1180) if you have any questions. xc: Environmental Management Committee - please route to the appropriate person ----Rob Bradford - please route to the appropriate person Dave Cannon Neil King Janet Matey Betty Moran Tom Robinson Bob Romano Has Shah Carol Stack Mike Walls OLI 4101 appeno;* a REFERENCE: AIR CONCENTRATIONS (RACs) FOR THRESHOLD CONSTITUENTS Constituent Mix tmijn Annui 1 Average Ground Level Concentration (ug/m5) acetonitrile acetcphensne acrolein a 1 uni nun- phospnioe a !> ! a Icons 1 antimony ba'lim bi' <u*r. cyan lae ben;icine bisIE-etnylnexyTlpntna late bromometnane calcun cyanide carbon aisulfice cnloroane i-cniorc-],5-0Ltaiiene cnlorcnetnane Ctironue 111 copoer cyanioe cresch cyamaelEree) cyanogen di-n-putyl pntnalate o-di;nloroben;ene dichlorcdifluoranetMane 2,<-dichloropnenol 1,3-dithloropropene diethyl phthalate dimethoate 2.A-d in itrophenol diphenylamine endosulfan endnn f lounne forma laehyoe formic acid 10 500 0.25 0.25 S o.zs 50 50 0 5 * 1C-*5 17 0.7 25 2 DC 5 x JO'3 ' 2.S 0.7 1,000 50 100 17 75 10 10 170 7.5 O.ZS 10 1.0 1.0 225 0.01 0.05 50 2 x 10`3 1700 237 OLI 4102 ArP[KDIX A (continued) Const Uuen: Maxinu/n Annuel Average Ground Level Concentration (ug/m'1) trw"'lie oxioe the 11 iu>r tna 11 .ut (1) acetate thallium (i) carDonate thallium (1) cnlorioe tnalliutn (1) nitrate tnalliuir. selenite tnalliur. (1) sulfate tciuene I,2.A-trichloroben;ene t r i cn loromonof 1 uo rome t hane u ,4.5-trichIoropnencl vane iiar. pentonoe v inj 1 cnlorioe 0.25 50 C 05 0.25 0.5 C5 0.5 0.5 500 17 250 100 17 0.05 239 OLI 4103 APp;SD!x B (coni injetl) Const Uuent NiCk-el (oanoon. 1 & Sucsjifioe) C-huropropane S-li itroso-n-mein,' ljrea ki-S lirosopynro' lC'ifc Peniach ioron t1rooeryene Pronarcioe Resenp'ne 3.1 . .C-Tetra;nioroethane let rapnloroemj lent Imo-rea 7r icr.loroetny lent Risk. Specific Dose (ug/ir.J) 3 10'! a * 10'3 1 x 10'S 2 x 10*? 1 x 1C'1 2 3 1C'3 2 * 1C'3 2\ 2 1C'3 a 241 OLI 4104 EXHIBIT 1 APPENDIX A CONSTITUENTS CHEMICAL acetonitrile COMPANY (based on SRI information) E. I. du Pont de Nemours & Co. Petrochemicals Department Intermediates Division Standard Oil Company (Ohio) acetophenone Allied Signal, Inc. Atlantic Richfield Co. ARCO Lyondell Petrochemical Co. Georgia Gulf Corp. Givaudan Corporation Texaco, Inc. acrolein Union Carbide Corp. Solvents & Coating Division aluminum phosphide none listed (but phosphate listed) phosphate (unspecified) Chesebrough-Pond's, Inc. Stauffer Chemical Company Basic Chemicals Division phosphate (mono) Chesebrough-Pond's, Inc. Stauffer Chemical Company Basic Chemicals Division Tenneco, Inc. Albright & Wilson, Inc. allyl alcohol FMC Corp. Industrial Chemical Group antimony ASARCO Allied Signal Harshaw/Fitrol Laurel Industries, Inc. McGean-Roheo, Inc. M & T Chemicals, Inc. Pennwalt Corp., Ozark-Mahoning Stauffer barium Barium & Chemicals, Inc. Chemical Products Corporation Deepwater, Inc. Ferro Corporation Transelco Division General Electric Company G. Frederick Smith Company GTE Corporation Harshaw/Filtrol Partnership OLI 4105 page 10 2,4,5-trichlorophenol vandium pentoxide vinyl chloride not listed Associated Minerals & Metals Gulf Atlas Intercontinental - Somex Kerr-McGee Union Carbide Corporation Stauffer Borden Dow Formosa Georgia Gulf BFGoodrich PPG Shell Vista Air Products & Chemicals Polymer Chem. OLI 4106