Document 2jVknBN568QnXkyxrD9LgQ0b6

VI. Swbxtonca 44 Dimethylphthalate........................................ 44 Diphenyl....................................................... Ethylamtne................................................... Ethyl sec-amyl ketone (5-methyl-3-heplan- one)............................................................. Ethyl benzeii'Ethyl butyl ketone (3-Heptanone)............... + C Ethylene glycol dinibate &/ niboglycerin- Skin.... ....................................................... Ethylene imine-Skin ................................... C Ethyl mercaptan........................................... N-Ethylmoiphotine-Skin............................. Piteous glass............................................... Formic acid ................................................ 44 Gasoline..... ............................................... sec-Hexyl acetate 44 Hexachloronaphthalene - Skin.................... lion oxide lume ........................................... Isoamyl acetate............................................ Isobutyl acetate........................................... 44 Isobutyl alcohol............................................ Isopropyl acetate......................................... 4 Maleic anhydiide.......................................... Methylaraine........................... -................... Methyl (n-amyl) ketone (2-Heptanone) ...... Methyl iodide - Skin ................................... Methyl isocyanate - Skin ........................... C Monomethyt hydsazine - Skin .................... 4 Naphtha (coat tat)....................................... 44 Nibic oxide................................................. 4+ Octachtoionaphthalene - Skin.................... Oxalic acid................................................... 4+ Parquat - Skin .......................................-- Phenyl ethet (vapoi)................................... Phenyl ethei-Biphenyl mixture (vapoi)...... 4 Phenyl glycidyl ethei (PGE)...................... Plval (2-Pivalyl-1.3-indandione) .............. 44 Propyl alcohol................--........ -.............. Propylene imina - Skin................................ Rhodium. Metal fume and dusts................. Soluble salts.............................................. 44 Ronnel--............................ ........................ Selenium hexafluoiide.................................. Tellutlum hexafluoiide................................ 4tC Tetphenyls........ ........................................... 44 Tebachlotonaphthalene - Skin.................... Tebamethyl lead (TML) (as lead) - Skin .... Tebamethyl succinonlbile - Skin............... Tiemolite....................... ............................. 44 Tiibutyl phosphate ..................................... 1.1,2-Tiichlotoethane - Skin...................... Xylene....................-.................................. 44 Zinc chloiide............................................... 4 1966 Revision 44 1966 Additions f For intermittent exposure only _ 5. 0.2 1. 10. 18. 25. 130. too. 435. 50. 230. . U.Q2t 0.1) 0.5 1. 10. 25. 20. 94. - 5. 5. 9. * 50. 300. _ 0.2 _ 10. too. 525. 150. 700. too. 300. 250. 950. 0.25 1. 10. 12. too. 465. 5. 28. 0.02 0.05 0.2 0.35 too. 400. 25. 30. _ 0.1 _ 1. 0.5 1. 7. 1. 7. 10. 62. 0.1 200. 450 2. 5. _ 0.1 _ 0.001 _ IS. 0.05 0.4 0.02 0.2 1. 9.4 _ 2. 0.07S 0.5 3. 5 mppcf - -- 5. 10. 45. 100. 435. - 1. Appendix A A1 Benzidine Because of high incidence of bladdei tumots in man, any exposuie, including skin, is extiemely hazatdous. A2 ^.Nophthylemine. Because of the extiemely high incidence of bladdei tumots in workers handling this compound and the inability to control exposures,j) -naphthylamine has been prohibited (tom manufactute, use and othei activities that in volve human contact by the State of Pennsylvania. A'N-Nitrosodimethylamlne Because of extiemely high toxicity and presumed catcinogenic potential of this compound, con tact by any toute should not be permitted. A4 Polytetrofluoroethylene* decomposition products, Theimal decomposition of the fluotocatbon chain in ait leads to the fotmation of oxidized products containing catbon, fluotine and oxygen. Because these piaducts decompose by hydro lysis in alkaline solution, they can be quantitatively deter mined in ait as fluoride to provide an index of exposuie. No TLV is recommended pending determination of the toxicity of the products, but air concentrations should be minimal. A*f) Propiolactone Because of high acute toxicity and demonsba ted skin tumor production in animals, contact by any route should be avoided. A* Gasoline. The composition of gasoline varies greatly and thus a single TLV fix all types of gasoline is no longei ap plicable. In general, the aromatic hydrocarbon content will determine what TLV applies. Consequently the content of benzene, other atomatics and additives should be determined to anive at the appropriate TLV (Elkins, et al. A.I.H.A.J. 24, 99, 1963). * Trade Names: Algoflon, Fluon, Halon, Teflon, Tetian Appendix B B.l THRESHOLD LIMIT VALUES FOR MIXTURES be considered as additive. That is, if the sum of the following fractions, Ci + Cz+. . . . Cn Ti Ta Tn exceeds unity, then the threshold limit of the mixture should be considered as being exceeded. Ct indicates the obseived atmospheric concentration, and Ti the corresponding thres hold limit, (See Example lA.a.). Exceptions to the above rule may be made when there is good reason to believe that the chief effects of the different harmful substances are not in tact additive, but independent as when purely local effects on different organs of the body are produced by the various components of the mixture. In such cases the threshold limit ordinarily is exceeded only when at least one member of the series (Cj or_C2 etc.) itself T. Tz has a value exceeding unity, (See Example lA.b.) Antagonistic action or potentiation may occur with some combinations of atmospheric contaminants. Such cases at present must be determined individually. Potentiating or an tagonistic agents are not necessarily harmful by themselves. Potentiating effects of exposuie to such agents by routes other than that of inhalation is also possible, e.g. imbibed al cohol and inhaled narcotic (trichloroethylene). Potentiation is characteristically exhibited at high concentrations, less probably at low. When a given operation or process characteristically emits a numbet of harmful dusts, fumes, vapots or gases, it will frequently be only feasible to attempt to evaluate the hazard by measurement of a single substance. In such cases, the threshold limit used lot this substance should be reduced by a suitable factor, the magnitude of which will depend on the number, toxicity and relative quantity of the othei contami nants ordinarily present. Examples of processes which are typically associated with two or more harmful atmospheric contaminants are welding, automobile repair, blasting, painting, lacqueiing, certain foundry operations, diesel exhausts, etc. (Example 2.) When two or more hazardous substances are present, their combined effect, rather than that of either individually, should be given primary consideration. In the absence of informa tion fo the contrary, the effects of the different hazards should 03122226