Document 2jRGk15zmZNXRkKKym0r57gyp

CHEMICAL manufacturers association August 15, 1986 TO: Health and Safety Contacts of CMA Member Companies FROM: Haney G. Doerrer Manager, Health,______ ,, Chemical Regulations SUBJECT: IARC's Classification of Potential Chemical Carcinogens On July 10, 1986 a memo was sent to each of you requesting your participation in a project to provide effective industry input at two upcoming meetings of the International Agency for Research on Cancer (IARC). A copy of that memo is attached for your review. A significant response was received from CMA member companies. This memo serves as a second notice on the project to those of you who have not yet responded. CMA has been invited to nominate an observer to attend the IARC meetings. As a representative of U.S. industry, the observer will be charged with communicating to the IARC Committee pertinent chemicalspecific information that may impact carcinogenicity evaluations. Since the chemicals/exposures to be considered number approximately 200, CMA has requested that your company selectively identify chemicals on the list, collect and assess current information on short-term tests and carcinogenicity, and make evaluations of carcinogenicity for those chemicals. The information will then be used to prepare the CMA observer prior to the IARC meetings. The attached memo explains the project in greater detail. If you are interested in having your company's chemicals represented at the upcoming IARC meetings, please return the attached form no later than Tuesday, September 2. I can be reached at 202/887-1282 with your questions and comments. Attachments B0R 007557 Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 2501 M Street. NW Washington. DC 20037 Telephone 202/887-1100 Telex 89617 (CMA WSH) July 10 1986 TO: FROM: Health and Safety Contacts of CMA Member Companies Nancy G. Doerrer Manager, Health, Safety and Chemical Regulations SUBJECT: XARC's Classification of Potential Chemical Carcinogens The Chemical Manufacturers Association has been Invited to nominate an observer to participate in two upcoming meetings of the International Agency for Research on Cancer (IARC). With the promulgation of the OSHA Hazard Communication Standard, these meetings have increased significance for the chemical industry in its duty to warn against potential human carcinogens. You are being asked to review a list of chemicals, to identify those sub stances of interest to your company, and to contact CMA by July 28, 1986, with nominations of company experts for proper chemical-specific representa tion of your scientific views. BACKGROUND A Working Group of experts chosen by IARC will meet in Lyon, France, from December 2-9, 1986, to assess the activity of approximately 200 chemi cals and complex mixtures in short-term tests. At a second meeting, to be held in Lyon from March 10-17, 1986, the degrees of evidence for carcino genicity in humans and experimental animals will be assessed for these chemicals and exposures. An overall evaluation of carcinogenic risk to humans will then be made based on experimental and epidemiological data. The list of chemicals/exposures is attached for your review. These substances have previously been evaluated by IARC in volumes 1-41 of the Monographs, but are under a second review because of the existence of new data. INDUSTRY PARTICIPATION The CMA Health and Safety Committee has established an IARC Work Group to organize industry participation in these two important meetings. The number of chemicals and short time period for assessment of this list has dictated a method of action that requires full CMA member company participa tion. Since a single CMA observer will be expected to have technical knowl- BOR 007558 CMA Health and Safety Contacts July 10, 1986 Page 2 edge of each of the chemicals to be considered at the Monograph meetings, the CMA IARC Work Group has constructed a tentative scheme to prepare the ob server. During the month of July 1986, the CMA IARC Work Group requests that you identify all chemicals on the attached list that your company manufactures, produces, or that present a specific concern. Next, you should identify company expert(s), e.g. toxicologists, pathologists, or health specialists, who will be asked in the upcoming months to collect-and evaluate all avail able published and unpublished scientific data, with special emphasis on short-term test data and carcinogenicity information. A classification for carcinogenicity on each chemical will made by your expert(s) using the IARC system. (IARC uses the classifications 1, 2a, 2b and 3 to evaluate potential chemical carcinogens. This system is discussed and described in the Preamble to the IARC Monographs.) CMA recognizes that there may be significant overlap in company inter ests in a given chemical. When we receive your list of chemicals and names of company experts, we will initiate joint discussions with you and other member companies who have expressed the same interest to equitably distribute the task of literature searching and carcinogen evaluation. Additionally, the work load for this project will be divided into two phases: 1) collec tion and evaluation of data on short-term tests in preparation for the December 1986 IARC meeting; and 2) collection and evaluation of data leading to carcinogen classifications in preparation for the March 1987 meeting. More specific instructions, recommendations, and a time schedule for comple tion of this project will be made available when you submit written confirma tion of your participation in the process. IARC issues draft working papers 4-6 weeks in advance of the Monograph meetings. This short review period is inadequate to evaluate chemicals of concern to industry, and does not provide the time necessary to train an industry observer. Our proactive efforts to evaluate chemicals for carcino genicity, as described above, will thus provide us with a timely and accurate comparison of proposed industry/IARC classifications. We will have a full month to identify those chemicals likely to produce debate or controversy, and can prepare the CMA observer for the discussions. The CMA observer will not have a vote at the upcoming Monograph meet ings , but will have the opportunity to contribute to discussions concerning the scientific evidence for classifying chemicals as carcinogens. The nomination of this observer will consist of careful selection from a list of names generated by representatives of CMA member companies. The CMA IARC Work Group encourages you to suggest potential nominees in the coming months. CMA will provide the administrative assistance in collecting member company assessments on the 200 chemicals/exposures, nominating an industry observer to attend the meetings, and training the observer in communicating chemical-specific issues at the Monograph meetings. BOR 007559 I CMA Health and Safety Contacts July 10, 1986 ?age 3 In conclusion, CMA. asks that you assist the industry in providing a rational, scientific evaluation of carcinogenicity for chemicals under IARC review. Please make the appropriate identifications specified below, fill out the attached form, and return to CMA no later than July 28, 1986: o Identify chemicals/exposures on the attached list that are of specific concern to your company. o Identify company expert(s) to assess the health effects literature and to evaluate the carcinogenic data on chemicals of concern to your company. A second notice will be issued in early August to solicit additional participation from CMA member companies on a chemical-specific basis. Your prompt attention will facilitate the organization and administration of this project. Nancy G. Doerrer of CMA's Health, Safety and Chemical Regulations Division can be reached at 202/887-1282 with your responses, questions, and comments. Attachments BOR 007560 CHEMICAL MANUFACTURERS ASSOCIATION INDUSTRY PARTICIPATION IN IARC'S CLASSIFICATION OF POTENTIAL CHEMICAL CARCINOGENS RETURN TO: RETURN BY: Nancy G. Doerrer Chemical Manufacturers Association 2501 M Street, NW Washington, D.C. 20037 (202/887-1282) July 28, 1986 CHEMICALS/EXPOSURES COMPANY EXPERT(S) TELEPHONE NUMBER NAME COMPANY NAME ADDRESS TELEPHONE NUMBER Signed BOR 007561 IARC MONOGRAPHS ON THE EVALUATION OF THE CARCINOGENIC RISK OF CHEMICALS TO HUMANS: CHEMICALS AND INDUSTRIAL PROCESSES ASSOCIATED WITH CANCER IN HUMANS: UPDATING OF SUPPLEMENT 4 (PART 14 PART U) BcpoBure TENTATIVE LIST OF SUBSTANCES AND EXPOSURES TO BE CONSIDERED (At IARC Monograph Meetings December 2-9, 1986, and March 10-17, 1987) Exposure Acetaldehyde Acrolein Jterylcnitrile Aetinemyein D Adriamyein Aflatoxins Aldrin Aluminium production 4-Amincbiphenyl Amitrole Anaesthetics, volatile Analgesic mixtures containing phenacetin Ihenacetin Aniline (and its hydrochloride) Arsenic and arsenic compounds Asbestos Attapulgite Auramine, mnufacture of Auramine Azathiqprine Beizene Benzidine BOR 007562 Benzidine-based dyes: Direct Black 38 Direct Blue 6 Direct Brown 95 Berylliw and berylliun confounds Betel quid with and without tobacco (chewing) Betel leaf Areca nut N,N'-Bis(2-chlaroethyl)-2-naphthyl-- amine (Chlornaphazine) Bischloraethyl nitrosourea (BCNU) Bis (diloramethyl)ether and tedinical grade chlorcnethyl methyl ether Bitunens Bleanycins Boot ard shoe manufacture and repair Bracken fern 1.3- Butadiene 1.4- Butanediol dimethanesulphcnate (Myleran) Cadmium and cadmium compounds Carbon blacks Carbon tetrachloride Carpentry and joinery Qienotherapy for lynphcns: MOPP, etc. Qiloranbucil Chloraafhenicol Chlordane/Heptadilar - 2- Chlorinated toluenes, production of: Banzai diloride Benzotridiloride Benzoyl diloride Benzyl chloride 1- (2-Otloroethyl )-3-cyelchexyl-lnitrosourea (CCNU) Chloroform QtLarcphenols 2,4-Dichlorophenol Pentadilaraphenol 2.3,4,6-Tetraedilarcphenol 2.4.5-Trichlarophenol 2.4.6-Trichlorcphcnol Chlaroprene Cholesterol Oiraoiium and chrooiua compounds ortho-Chrysoidine Ci splatin Clofibrate Coal gasification Coal-tar pitches Goal-tars Coke production Creosotes Cyelaoates Cyclophosphamide Dacarbazine DDT Diazepam 1,2-Dibrc*B3-3-chloraprcpane i ortho-Pichlorobenzene and para-Oichlorobenzene 3,3' -Dichlorotoenzidine Didiloroaethane 1,3-Ditdaorcprcpene Dieldrin Diethyl sulphate 3,3'-Oimethoxybenzidine (ortho- Dianisidine) Dimethylcarbemoyl <iloride Dimethyl sulphate 1,4-Oioxane Gpichlarohydrin Erianite Ethylene difc* snide Ethylene oxide Ethylene thiourea Fluorides (inorganic, in drinking- water) 5-Fluorouracil Fb: Furniture and cabinet making Haesmtite mining, underground (with exposures to radon) Haesmtite (iron oxide) Hexachlorobenzene Hexadilarocyclchexane Hydralazine Hydrazine Iron and steel founding BOR 007563 Exposure -3 Iron dextran oooplex Isexiiastinic acid hydrazide Isopropyl alcohol mnufacture (strong-acid process) Isopropyl alcohol Isopropyl oils lead and lead ccepounds Leather dusts leather goods mnufacture Leather tanning and processing Usher and sawmill industry Magenta, mnufacture of Magenta Melphalan 6-Mereaptcpurine Methotrexate 5-Methoxypsoralen (> UVR) S-Methoxypsoralen ( + UVR) Methyl bromide 4,4'-Methylene bis(2-^hloroaniline) (M3CA) 4,4'-Methylene bis(2-methylaniline) N-Methyl-N' -nitro-N-nitraeoguanidine Metronidazole Mineral oils Histard gas 1-Naphthylamine 2^fephthylamine 1-Naphthylthiourea Bcposur Nidcel refining Nidcel and nidcel copounds Nitrogen wstard Odiratoxin A Oxymetholone Fhenazcpyridine (and its hydrochloride) Phenelzine Ehenobarbital Rienoxyacid herbicides 2.4-0 and esters 2.4-DP MCPA MCPP Silver 2,4,5-T and esters Phenylbutazone N-Rienyl-2-naphthylamine thenytoin Folybrominated biphenyls Polychlorinated biphenyls Prednisone Procarbazine hydrochloride Propylene oxide Propylthiouracil Pulp and paper mnufacture Reserpine Aibber industry Sacdiarin Sepiolite BOR 007564 -4- Sex hormones: Cabined oral contraceptives Ssquential oral contraceptives Other oestrogen-progestin cotoinations Androgens: Testosterone Oestrogens: Chlorotrianisene conjugated oestrogens Dienoestrol Diethylstilboestrol Diethylstilhoestrol dipropionate Ethinyloestradiol Hexoestrol Nestranol Oestradiol-17s and esters Oestriol Oestrone and oestrone benzoate Progestins: Chlomadinone acetate Dimethisterane Ethynodiol diacetate 17o-Hydroxyprogestercne caproate Lynoestrenol Medroxyprogesterone acetate Megestrol acetate Norethisterone Norethisterone acetate Norethynodrel Norgestrel Progesterone Other: Clomiphene Clcraiphene citrate Shale-oils Silica Smokeless tobacco prodicts Soots (and soot extracts) Spi rcnolactone Styrene Sulfafurazole Sulfamethoxazole Talc Tetrachlorodibenzo-para-dioxin (TCDD) ----- 1,1,2,2-TetracdU.oroethane TtetradUoroethylepe 2,4- and 2,6-lbluene diisocyanates ortho-Toluidine Tteosulphan (^TTrrii(dd.aroethylene 4,5*,8-Trimethylpsoralen (+ UVR) Tr i s (azir idiny1) ^ara-benzoqui none (Triaziquone) Tris(l-aziridinyl) phosphine sulphids (Thiotepa) Uracil mustard Vinblastine sulphate Vincristine sulphate Vinyl chloride, Vinylidene chloride Vbllastonite Mood dusts BOR 007565