Document 2jOBYBD5kwR7RqEyZx2OVnoQR

MANUFACTURING CHEMISTS ASSOCIATION H7* CON*CCT*CUf AvCNuE N W WASHINGTON 0 C 70009 i709> aJi?* Marcfc 21, 1975 Technical Ta*k Orcop oe vloyl Chlortdo ftaaaarch SUBJSCTi AttadMd tor yamr Infrr--11 r<i m tJa IoIIooIa^i 2. A eopf of th |f>f yroaaotad by 9r. Qnrdoo of Induatrial AIO-TMT UtentorlM at tbo M 5 mo*1 of tha lotorMtlonal of Pathology i Orloaoo Mtitlai "Cooporiooo of tho mrnrjbolofio Paatmroo of aopotic AoqioaarooM ia fta tai MmU Pollootaf fraloaytd tipoiari to Vlayl Ctlorl4.a 3. A mm nlnw te mllakllltr of a m book aotltlof "lho NtaiaUati- of vloyl Chlocido - A fUrt Maaal, * pobliafcof by tha CkMioaX Xotaotrioo Aaoociatioo Uaitad, AlaMtc boa. 93 Albort MobaM, Loodoo MX 7TO M/oto RSV 0020465 TPVC* 4 arlitr interim report date 3 Miy 9 had been mi led to tht Panel prior to the meeting. It covered grota and histopathologic findings in Mill groups of rats sacrificed after one year. Jt ms agreed that if the secretary did not receive coes :nti to the contrary by June 7, concurrence would be assumed. In that case these reports would then be side public including 'istributlon to appropriate government agencies. The secretary relayed a question fros Dr. Gordon of 1ST regarding the examinations of brain tissusa from aninala that had died. Dr. Gordon felt such U/orsation could be useful la the light of Professor Maltoni*s reported correlation of tumors in animal and human brain tissues. Similar wort oo sacrificed animals la already covered in the MCA agreement with IMT. This is to be rssolved by Dr. Torfcelson. (Botei it hes since been reported by Dr. Torts Ison that in the future Ilf will attempt to examine brains from sll animals, including those found dead.) ' torn* of Do* Studies 4.1. Metabolism At the meeting. Dr. Torfcelsoa gave the secretary a formal interim report. September 1. 1974 to Nty 1. 1979. from Dow to be reproduced and distributed to the Panel. Dow is also prepsring aa article besed on this information for piblieatloo in a ecloatifie journal which will be distributed to the sponsors. 4.2. Teratology It ia expected that the fiael report will be completed by the end of this suaaer per Dr. Torts Ison. 4*3. Matagenlsla The report is currently in preparation and should be reedy wlthiag two weeks per Dr. Torkeieon. 7. financial Statue Mr. A. C. Clark summarised the financial data on tha project and a copy of his report is attached. Tha Penal was also informed that since so many changes had occurred In the Industry recently, reported capacities were being updated by questionneires to management contacts. RSV 0020466 0*MAT70 COPY MANUFACTURING CHEMISTS ASSOCIATION c Claak ,rf P^VU*' I m-f i, :-mf un 2. \)T5 Philip H. Afcelaon. Editor "Science" 1515 Massachusetts Avenue, N. W, Washington, D.C. 20005 Dear Or, Abel son i The Entail article, 'Scientific Freedom and teapc.asibility " (J. T. Edsall, "Science," May 16. 1975) requires coeetut. I presume Or. Edsall is not responsible for the content of the arti cle, but merely prepared it frost the AAAS eowittss report, flow ever, scientific freedom end responsibility are as important tor AAAJ comlttee* as they are for other scientists. The "case of data suppression concerning the carcinogenicity of vinyl chloride" (pg. 690) is a melange of omissions and untruths inconsistent with scientific freedom and responsibility. Since so nneh pertinent information has been omitted concerning this mstter readers may bn misled into believing or. Bdsall's report. Edsall states that, "up to that time (May 1970) then had apparently been no reeeart* in the plastics industry concerning the possible hasarde of vinyl chloride...", This is untrue, 2m fact, the basic published data on vinyl chloride tonicity ana from American industry, (r*f*MM 1-7) information in refer ences 4, 5, 6, and 7 had been publicly disclosed and presented prior to their publication dates, Furthermore, the investigations of Or. F. L. viols and Or, Jtoltooi have been supported by Wnrrgiean industries. Sdeall correctly states that Itonufactoring Chemists Association (MCA) eenber ooapenles entered into an agreement with the European sponsors of ftaltoni's vocfc not to reveal Xtaliar data. The agreement eas not disaiadlar to thnt hetee an Anerlean sponsors (Oovemnant, Industry, and Aendenie) sad research institutiona that ne data rsmsln the property of the institution and not be disclosed until the study is ooglstsf and evaluated prior to disclosure of final results in proper scientific channels, Thera wns no intention to withhold adverse data, Under MCA rules, all data developed under its auspices must be promptly reported publicly, without exception, this has been done with all data on vinyl chloride. RSV 0020467 Philip *. AbeIson 'ScitnM* tor June 2. 1975 P*9 2 U. S. Government scientists Vnew of Maltoni's pre1lainary results early in 1973 but considered it as preliminary as did U, S. industry. At the Second International Symposium on Cancer Detection and Prevention in Bolocna, April 9-12, 1973, Dr. Ksltoni showed a table of preliminary results linking vinyl chloride with cancer formation^ (wt published until 1974). Dr. thnberto Saffiotti, Associate Director of Carcinogenisis, Rational Cancer Institute, was present at the meeting and subsequently discussed the results with Mai ton1 at his Italian laboratory.9 Saffiotti felt that the work needed to be included in *a well documented report* to be assessed by the world Health Organization (Review Panel of the International Agency for Research on Cancer of which the United States is a mast-- ber). This coamittee also considsred Hal tool's data preliminary at that time and 'decided to postpone compilation of the definitive review to the next meeting of the committee.*9 relieving a period in which epidemiological end animal studies were being established, MCA on April 17, 1973 esked the European# to jointly make presentations to United States and European Govern ment authorities. The Europeans readily agreed, and on June 15, 1973 MCA eelled the Rational Institute for Occupational Safety and Health (V206B) and requested an opportunity to bring new information to that agency's attention. The appointment was set by RIOSH for July 17. five European and American industry representatives presented to RIDSa the information that tumors had been obeerved at concentretions below that reported by viola. At that time, human cases had not been reported! therefore, no special significance could be attached to the types of tumors obeerved by Multoni. The MCA suggested label referred to by Bdsall vns illustrated in the Chemical Safety Data Sheet (SPSS) on vinyl chloride, revised April 1972. Section 10.1 on Bee 1th Buserde refers to viola's pub lished studies. The Data Sheet states "Recent research studies reported from Italy indicate that repeated, long-term high level exposures of rets to vinyl chloride ennomer vapor can result im the development of malignant tumors. However, smny years of in* duetrial experience with human exposures to concentrations frequently far above current standards have not demonstrated any carcinogenicity to husians." Thus the statement by Ed sail that MCA "...appears to have deliberately deceived RIOSH regarding the true facte.* is inac curate and misleading. Sincerely, RSV 0020468 fteferenceei (1) Torkelson, T. T, Oya, and V. 1C. Itoit Thm toxicity of vinyl chlorlda as determined by repeated exposure of laboratory sniaals, American Industrial Hygiene Association Joonul, 22(5) . 354-361. 1961. (2) Wilson, ft. It., W. E. McCormick, C. F. Tat, and J. L. Ci Occupational Acroosteolysis, report of 31 casas. Tba Journal of the American Madical Association, 20118). 577-581. 1967. (3) Baretta, I. D., B. D. St--rt, and J. I. MatcdUar. Rxposure to vinyl chloride vapori breath analysis air sampling. Anaricaa Industrial Bygiaoe Uioclifloa Journal, ?0. 537-544. 1969. (4) Diman, 8. D., W. A. Cook, W. M. Mhitakouma, I. J. and ? Ditchecfc. Occupational Acroostaolyslat X. An logical Study. ArdklvM of Environmental Baultfc. 22, 61*73* 1971, 5) Cook, W. A., 9. M. Oiavar, B. D. Disaaa, ccuputional Acroostaolyula i IX. An Industrial Archives of Bnvlronaaotal Baaltk, 22. 74*83. 1971* (6) Doda and J. study. Archives of Bnri > A. I. 8. mmmm* it XXZ. A oUnd--l il Baultll, 22, 83*91, 1971. (7) Kramer, C. 0., and J. 8* ItatAlar. and asviromant seasu-'anssts for uorttert Anarican Industrial Rygitat Aaaociatlon J af tllrtml to vinyl 1. ^3C1I. 19*38. <8) Maltoni, C. Occupational Carcinogeniala. Second International Byapsuim on Concur Dutnctlm Bologna, April 9-13, 1973* Bhoerpta Nadiea,9 (9) Bearing bafora the Butii imittaa on Bnvi.rnnm--it of on Co--Tct, On1tad Stataa Sanato, August 21, 1974, (Burial Vo. 93-110) on Dangers of Vinyl Chloride, pages 54*54. JWlj o/j 7^-: Casar* Maltoni*, Adriano Cilibarti*. Luciano Gianni* and Pasqualo Chiaco*: Tt>a appaaranca of angiosarcomas in rats following oral adad.ruaeration of vinyl chlorida** (Insorganza di angio-- sareooi in ratti, in saguito a soooinistxaziona par via oral* di cloruro di vinile) Ospadali dalla Vita, 2 (1), 6S-C* (1975). . *ZMtitata of Oncology and taor Coal Hospitals of Bolofu, Rsgioaal lotpital Orgsal in fiald of Ml Translated froo Italian by ThaR^lpk McClroy Co., Custom Dlvisioa* 2102 Rio Grand*, Austin, Taxas 71705 USA RSV 0020470