Document 2j848rmrrYn9aBmknZk5d1vw5

MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W. WASHINGTON, D C. 20009 (202) 483-6126 URL 16905 REG"'' jU\_U''377 July 20, 1977 TO: Technical Panel on Vinyl Chloride Research SUBJECT: Technical Paper Entitled "Cross-Sectional Epidemiologic Survey of Vinyl Chloride Workers" Gentlemen: Dr. R. -S. Brookman of the Firestone Plastic Company has thoughtfully made available to us the subject technical paper. We have attached the title page and the abstract. Should you desire a copy of this treatise in its entirety, please address your request to the Project Manager. Sincerely "J. T. Seawell Project Manager Vinyl Qhloride Research JTS:ec Enclosure cc: Dr. R. S. Brookman Dr. T. R. Torkelson URL 16906 A CROSS-SECTIONAL EPIDEMIOLOGIC SURVEY OF VINYL CHLORIOE WORKERS Richard 0. Waxweller, M.S.I.E. Henry Falk, M.D., M.P.H.* Anthony McMichael, M.D., Ph.D.** Joseph S. Hallov, M.D. A. Scott Grivas, M.D.* William T. Stringer, M.S. Cancer and Birth Oefects Division, Bureau of Epidemiology, Center for Disease Control, Atlanta, Georgia ** Occupational Health Studies Group, University of North Carolina, Chape) Hill, North Carolina DEPARTMENT OF HEALTH, EDUCATION AND WELFARE Public Health Service Center for Disease Control National Institute for Occupational Safety and Health Division of Surveillance, Hazard Evaluations and Field Studies Cincinnati, Ohio April 1977 jh/f.! "i-M- <z&-%&-i , ABSTRACT A considerable number of studies have associated occupational vinyl chloride monomer (VCM) exposure with a variety of adverse health effects. The extent to which VCM induces these abnormalities in the workforce is not well defined. This cross-sectional medical survey of 433 predominantly white male employees, divided into four VCM exposure groups (never, light, heavy, former), deter mined the prevalence of illnesses and abnormalities based on data gathered by interview, medical examination, blood and pulmonary function tests, liver scans, and hand and chest x-rays. Age-adjusted analyses indicated that hepatomegaly, central nervous system symptoms, diastolic hypertension and spouses' fetal wastage (the Tatter two statistically significant at p <051 wSre^more prevalent among oast or presertt~VCM expQseo workers than among controls. Although VCM-relatcd respiratory system problems, acroosteplysis, Raynaud's phenomenon, and chromosome aberrations hav<T been identified by otner investigators, no excessive prevalence of these toxic effects was found in this population compared with industrial worker controls. URL 16907 Ill /