Document 2j552a0EEe4OD3xRz72QkYGBg

April 9, 1968 .'ir* Jones Armstrong Mcicer Aluminum it Chomical Company Tront'./ood Korka ..poJ'.ene, VnuhLngfcon 99210 Door Mr. Arnotrone 1 Mr. Pogue or our Seattle office has aoked me to forward toxicity and oaf# handling information relative to our firerooiatant hydraullo fluids, Pydraul 312 nnd Pydraul A-200. The oral toxioity of Pydraul 312 chows an LDtn to rats of 6900 ragAc and it is olasoiflod as 'practically non-toxic" from tho acuta oral point of view. When applied to the akin undiluted and allowed to remain overnight, a barely peroeptlVlo reduces occurred, giving 0 maximum acore of 1.3/8.0, which was classed as a alight irritant. The material proved capable of Leing absorbed through the skin in high doeea when allowod to remain on the rabbit under a cuff. The minimum lethal dose was comowhere over 2000 and under 3)00 mg/kg. This would foil into the "slightly toxic'' range. The material is a alight eye irritant when applied undiluted to the rabbits* eyea and there was mild diacomfort and alight rednesa. The maximum aoore woo 13/110 and the eye had returned to normal within three days. ilats survived six-hour inhalation exposure to the vapors evolved nt ambient temperatures following the passage of air through the material* No systemic effects wore noted. Animal toxioity studios with Pydraul A-200 have Indicated that the oral lethal dooe to rats is 13,500 milligrams per kilogram. The lothol dose when the material was applied undiluted to the unlrokon akin of rabbits la approximately r?5) milligrams per kilogram. The akin and eye Irritation end vapor inhalation teats results were comparable to the data for Pydroul 312. COMPANY CONFIDENTIAL TRAN 058123 HARTOLDMON0042270 Mr. James Armstrong -2* ,April 9 19GJ3 Ve conoludo from the above that accidental ingestion on the part or humans lc not a particular horard in view of the high oral lethal dose in rats. Similarly* single massive akin expoourcs should not be immediately harardouo. The lethal dose obtalnod in skin penetration studies is ouch* houovor, that prolonged and repeated skin contact should be avoided because of posolblo systemic effocts. In addition* prolonged and ropoated skin contact may lead to skin irritation. Vo also feel that vapor inhalation should be avoided when the fluid is heated to elovstod temperatures. Guch exposure again relates to prolonged or repeated exposures rather than short-term massive or acute exposures. In the case of the latter* workmen would not voluntarily oxpooe themselves to concentrations that are hazardous because of Irritation of tho respiratory tract. I have enclosed a oopy of a summary of our Interpretation of the data for Pydraul 312. The information applies similarly to Pydraul A-200* If I can be of any further help, please let me know. Sincerely* RSXicJs cc> D. R. Pogue - Seattle BCC: N. T. Johnson Enclosure A, Smraot Kelly* M.D. Medical Dlreotor COMPANY CONFIDENTIAL TRAN 0**12, HARTOLDMON0042271