Document 2Xnvy2xYV6RxBooq0LXpbp9g

^SK.^. Cop ie? to: E. I. du Font de Nemours^BB Cor.pany Haske11 (Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 45-78 AR226-2869 * Material Tested ^9 HasI<el1 No. 1,921 Sample Ready for Testing 7-20-77 Other Cod(is fBBH EYE IRRITATION TEST IM RABBITS Mate'rial S iBBr Depar+men"!-, Cham Procedure: One hundred milligrams of waxy test material** was placed into the right conjunc+ival sac rabbt+s. Twenty seconds after contact, one treated eye was washed with TB( va+er for one minute. The other rabbit was not washed. Ofservattons c' ne Cornea, irts and conjunctiva were made with a hand-s four hours and at one, two, and three days. biomicroscope and Ftuor-i-s+rip stain were used at exa day of treatment. ** The separated oil was remixed well with the waxy solid Results: Dose 100 mg waxy test materia I 100 mg waxy test material Treatment of Eyes Not washed Washed Cornea None None Iris None None Ocular Effects Conjuncti Redness: Mild 1-4 hours. Swe111ng: Slight 1-4 hour Discharge: Mild 1-4 hours Redness: None Swell ing: None Discharge: None -2- Summary: ^j^^^^Byp reduced transient very mild conjunct ivi+is with no cornea! or iri+ic effect when te eye. An eye dosed with the compound and promptly washed had no ocular effects. Both isyes were normal w Although only transient minimal ocular effects occurred, good hygienic practice would be to flu any eye contact. -:n)5 Report No. 45-78 Date Issued: February 17, 1978 Report by: /He^-^''S^^--<L Doris F. Edwards Tox i co 1og I s+ Approved by: ^f ^ ( )JLA r^u^j-<^-^'- Nei I Knvanek Chief, Dermal and Ocular Tox