Document 2RyNM76jaJMwjRyqgkvKbG3L
July 18, 1975
Dr. J.C. Calandra Industrial BIO-TEST Laboratories
1N8o1rt0hbFrrooonkt,age11E1d.. 6oo62
/
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re: AROCLOR 2-year Rat Feeding Studies
Dear Joe;
The attached table--ErinMiarIzes a comparison of the 3 revised AROCLOR reports ((1242y> 1254, 1260).
In 2 instances, the previous conclusion of "slightly tumorlgenic"
was changed v-o "does not appear to b uarcii'iogeiilc". , The latter phrase is preferable. May* we request that the AROCLOR 1254 report be amended to say "does net appear to be carcinogenic".
The number of hepatomas reported for AROCLORS 1260 and 1242 have been Interchanged. This appears to have arisen from con fusion regarding the numbering of the animals. The original
reports show tumors in animals with numbers in the 100-300 range
for Ak OCLOR 1260 and in the 500 to 800 range for AROCLOR 1242. This leads me to conclude that the numbering scheme shown in the second set of reports is correct. With AROCLOR 1254 confusion is compounded. The original report showed tumors in animals
with numbers in the units to teens, but the revised report-shows animal numbers ranging from 40 to 1000. Can this be straightened out?
I was unable to reconcile the differences in the animal numbers between the first supplemental report and the original reports, I had inquired as to the changes in the numbers. As I recall", I was told that the sections had been renumbered when the new slides were made and that a key relating to the seta of numbers
NEV 000008
Dr, J.C. Calandra July 18, 1975 Page - 2 -
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would be supplied. This has not been done. It may not be necessary for AROCLOKS 1260 and 12*1-2, but AROCLOR 1254 remains unresolved.
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Insofar as I-can see., the remainder of the reports appear acceptable.
Kindest personal regards,
Sincerely,
George J. Levinskas, PhD Mgr., Environmental Assessment
and Toxicology
/bkp
att. cc: Dr, George Roush, Jr., M.D.
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-D*
Product
Supplemental Report
#1 (mailed)
AROCLOR 126o
conclusion hepatoman.
slightly tumorigenic
r 10
3
range of test animal nos:
p. p.
109
*
600 to 800 1000 series
p. 11
70 to 100
p. 12
500 to 600
p. 13
600 to 700
p . i5
700 Beries
Supplemental Reuort #2 (JCC delivered'
does not appear carcinogenic
7
100 to 300 800 to 900
lOtto 40
80 to 200
200 to 300 200 to 300
AROCLOR 1254 conclusion
hepatomas
slightly tumorigenic
6
slightly tumorigenic
6
AROCLOR 1242
conclusion
slightly tumorigenic
does not appear carcinogenic
hepatomas range of test animal nos.
73
as in report #2 as in report #1 for AROCLOR 1260 AROCLOR 1260
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