Document 2Ro33GELOKojvpkk47BX2ONXN
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D.G. WEIBLEN
222030161---11155 222230036116----1131~85 22220230160----2321BE85
201-IS
SSuubjbejcet~:t:PRFauMt--3344T22o22xicity Study RRReeatqquueeTssottxiAAci66t77y882200Study AapprriiZl 66,, 11997388
T0O:: JI..EE.. LLONNGG FFRROOMM:: JJOONN BBEELLIISSLLEE
222200--228E 201-15
201-1S
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for FC - 95.
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hhthaaennddsllieinrngugmttseeaccmhhpnnliieqqsuueeveaarppepprrooappnrraiilaayttzeeed
the serum samples were analyzed
for total fluoride content.
RWATT
saMatlee HMaallee aMallee
DDOOSSEE ((ppppmm)) 0 o
1I0000 330000
3422
3422
in
in
serun
serum
((pppmp)m~ TTOOTTAASLLERUFFNLL_UU(OOpRRpIInDD)EE
TIMN
SERUM (ppm)
0
0.6
0.6
oa z-O.1
1LO000
~<00.1
228055
reFnemaallee
0
0
-
FPeemnaallee
1i0000
<~ 00.I
(20
Female
Female
330000
<~ 00..3
L20
2s
~Greeppoorrtteedd iinn MMaarrcchh 1133,, 11997788 lleetttteerr..
~35
FFLLUUOORRIINNEE - - - MN MRR
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NNlMAeRRv..el wTTahhsee mmaaa~lldeeedssFeeCrr-uu9mm5-- (33C00s00FIpTpSppOmn3'K33)442222andwwaassthepprreesppaaamrpreleded pfFroorerpaNWMrHRRe.,d for
Exhibit 1166
1111666..00000011
awA10038579
3MA10035579
2 -
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The F/NMR spectrum of the 2 samples were identical (slight difference seen in branching). This means that the serum contains CSFI?SO3- that the rat has metabolized from 3422.
DISCUSSION
rod sugges, eh Shs uty ending BEE (Cot I would suggest that this study feeding FM-34~2 (CsFITSO2-
NFF(CeC-<283H00s77)C((HC2sCCFHI2?aOSHO)PRN(a(1CnCldRg7H)as}C5CplHriRe0zCvCHiH22oZOu0PsPH--))stuiindnywwhhwiiictchhh
mboitche
both
sfeereudminsg were
serums were
fITtoouniidmmppll[ii~ee/ssNMRtt)hhaatttoaanncyyont33aMMinpprroCoSddFuuIcc?ttSObb3ee-aarriiinnsgga tthsheeigCnCisgfFPiI)cT7aSSnOOt2ZNNCCfHHi22n--ding.
sie en sponte boKuboeleWold elernie Carlee group upon exposure to rata or mice would @enerate CsF17SO3-
which accumulates in the animal's blood and tissue (see liver
analysis to be reported later].
im ot IR AALS Soi SETI 3 The next step would be to extrapolate these findkngs to man
per Guy and Tares research. Thus, I have suggested before
and will state again the significance of characterizing those
Spoeinnehere persons SoC Shen heplbuic hell fine, previous samples from 3M employees exposed to 3 M's skin
protectants and carpet treatment products. If CsFI?SO3- is found in these persons blood, then the public health issue becomes simply one of frequency and type of exposure to 3 M products.
wRiebeelo
11116666..00000022
3MA10035580