Document 2RjekX90DoKLMQpkXo0k9rRy6

A Ae22-1600 J!--_-- F sau rTHosm TLETON Prevatared TeflonDivision wae DAC ow Ju Gm ly Hess renaed Aang Lorman . 000138 EID079371 E. I. bu PoNT DE NEaMOUR&S COMPANY PaneRPs.ou0.RGB,oxW.12V1a7. 26101 POLYMER PRODUCTS DEPARTMENT CC: CS.. GH.ayMacsBhlio-nTeok-yTookyo D. K. Duncan - Wilm. Septenser 15, 1961 MMRI.TSUSI. TFALKUAODRAOCHEMICALS CO. LTD. HSHIIHMOIZ3U600 JSnHoIaZNUOKA PREFECTURE PROPOSED EMPLOYEE BLOOD SAMPLING PROGRAM We would like to obtain blood samples from a representative group of employees at Shimizu Works to determine if there is a significant difference between C-8 APFC dispersing agent values at shinizu and Washington Works. About twelve samples should be enough. They should include several people who work arownd the TEFLON fine powder dryers because we believe that they are a major source of exposure. Your plant has batch dryers whereas Dordrecht and Washington Works have continuous dryers. MWe will analyze the samples at Du Pont's Experimental Station and return the results to you so that they can be given to the employees as confidential medical information. : i. 3 EIDO079372 2 There's a world of things we're doing Something about 000139 . -2- BACKGROUND We have used C-8 at Washington Works for more than 25 years and in earlier years it was handled less carefully than in recent years. Limited data indicates that C-8 is persistent in the human body and we have established a program to monitor selected employees regularly. We have established engineering controls to reduce potential exposure to C-8 and required the use of protective equipment for some Jobs. | Significant additional control effort began in 1979 after 34 Company(our supplier of C-8 APFC dispersing agent) advised us of accumulation of organic fluorine in the blood of some of their workers. In March, 1981, 34 Company advised us that tests indicated that oral doses of C-8 caused birth defects in rats. As a result, we transferred all females of child bearing potential from jobs with significant potential for C-8 exposure and increased our efforts to prevent exposure. Du Pont's Haskell Laboratory is making tests to determine if exposure by inhalation of C-8 causes birth defects and also is making tests with oral doses similar to the 3M tests. We expect results of these tests in' about a month. 3M Company is repeating their original study and we expect to receive some information in October, 1981. 5 ~ EID079373 0139 000140 a -3- | Samples of blood taken at Washington Works showed that polymerization operators had an average of about 5 ppm organic fluorine and the maximum value was about 29 ppa. Monomer operators and professionals generally had much lower values. We sampled some employees in the TEFLON Division at Dordrecht Works in May, 1981, and we found that the C-B content of their blood samples was very similar to results at Weshington Works. There appears to be no background level of naturally occurring C-8 in blood samples. A thorough study of the employees health records showed no conclusive evidence of effects resulting fron exposure to C-8. . We have asked Haskell Laboratory to establish an acceptable level for C-8 in workers blood that will be the basis for managing our blood monitoring programs. We will be glad to answer any questions and provide more information that you may need. Paul Thistleton Senfor Engineer : Technical Department P/nsw Pre se "000141 - EID079374 ~ |0 ( M aml ofwl rg I 8 BLOOD SAMPLING RES 4 Births and Pregnancies s plate Cnn) ics : i Ll Status * : ul } 275% 0.45 NNoorrmmaall chcihillddC-eboofmFJluunoeroc1a98r0b.ons 4/79. [ 27045 0.28 Normal child - born April 1981. A hi3 Er o.078 NUomrbmialilcaclhilcdord- bbolronodAp0r.0i5l51p9p8m1.. w8 ' 0 Fis{ve-months-pregnent.onpeaar Lovre a EUA6N67 ly DoS 2t3a44f9 0.0 0. ivemonths.pregaant. Plprred Jp Qugt Its! Jnsen 6 O"58+ 2.5% - COhhiclidr-m2edplouyse'yaenards.tear duct d.efect. wss 254, 7 177% 0.048 child - 4 months. Et aa J Binds Sims 8 512 21007 red hi~terss lye 1191 #bCeufrorernetpbrleogondanclye.vel - in fluorocarbons area only one month ETE ON = 2 1 000142 HD079375