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PFOA T- 11226644..00000011 Exhibit 1264 3M_MNO1691770 3M MN01691770 RREECCEEIIVVEED~ TOXiZoLCay rt opT iate mT t of ees Ooszn "-~_r':od' Suudy Dir~ctoz: 0681RB0331 meme -'~i:;er LaS.'ratc,.".e$, Lnc. ]u]..~ 16, 1981 to ~.~ptember 4, :981 w., Go Gor'lner E Lael r BEBio n er yptry e dim T Domus Lioinfrre sas) oC tV ap,lsRlo7cE GasTricelawre 11226644..00000022 3M MN01691771 x Introtuetion ZntroSuction ThTh3ti%esao1or0arolac,lEbrraafnongrgeeffiinsndudebersreqssutteuundetyy-aOrvweaalss tcceoornnaddtuuacclttoeesddyttuoo ddaeetteeirmnmiinrneaebbctihhtees.uuppppheerreddsootssueedylleewvvaeerll of of CTScTsopo-pR-nono3L1dndn,4usus1cocoCMtrtrOieeeenCddddn--ebbbbsyyyyfootcrt33ahhM:eeaCCSsSooaTaummhrfbmeeeesertcercyygcsiuicaeauEElnlcvvtyaallCCvuuohreaareerattmmliiiioocccnenoatlnledLrLuaaaDDcbbitiootvovrreiilaasdsottiigooooyurrnnnyy,,s,,tauSScdTtRRc,.yiiokkreePiPdnrraanucclkLLr,seaaanbboobMwPrLiriiiatantntstnhno.oeerrscssiohoeetetTssaah,,ea4afnsnIIeddntnrcuc.ydaw.,yaswSat.s EsEEIPatveiuhoaialrllr,eauiagaagteteMiisiooanlSnfnnooeecctsLaaLyotatacibibaooooaonnrrtaaottffnooooTrrtrrhyyei''ttosshhsneetuSSTLdtrLyeaaaAwynbRdwoAaaGdrRsreaaEdtttaacoOSorpapnaynened.adruracettateaeiicdnSncogoogrppidyyPnPrroaoooafcrfccceechddtotiuuhhrvreredeeeasssFfn:icinfefnaooarlrwimTtrsuheueccpphhootrrhtstesttuuiSibdssaiifeemmesraat.:iiynnttaaTTiihhenneeedd in the Safety Evaluation Laboratory's record archives. Mneetshhoodsss FfELFnroorsorsoemttcyyt--DDeeauudiittgcgcvhhhhilltttaahnnssddeex1xLLu2aaai3bblloolyrryoaafttmmooaaprrttiiiuuteerrusseei,,taNereITwynwncco.MZZ,,weetaaawvlleieaarrnnneeiddziuuWWnsshhgeeiiddctheeoi//inrnMMmiiontntnhhiieeekkiisvnnstituuaddddeeyyrrt..ihievveeeddEEsaarccffhheemmvffaeaeiellnmmeeaallbrreeeaafbbovwbbraeiiesrtss bibirrnleejineeddceiitsnneggd..SewmietTTnhhh.ee I ddTmoohuegessovafweaerrypeeitotftuhhieetinnanrsyaaerrmt~iliinuffatiltecicioilnnaaillzvlllayynsgiidhnneosssreeimmmgoiinnnnaeaattteeevdddiawvaaiitytthhhe0e00oa..f55r mmpvlireeiogonffnabnppecofoyoou.rileeedd diluted semen. The day of insemination was designated day 0 of pregnancy. aEEiiinggthhtitliggerrdoouuppvesateoorff 66ataann3ii00nm,aallss15wv0,eerree10dd0,oossee5dd0,wwii2tt5hhoTrT--23111044m11aCCyOoKCCg/dddiiassyss.oollvveeMdderddeaaiillwyyereiinntwo sete moS"odfgfhio/is/kacctxogtoiom/lmlaledpl~aoaeoyuvyd~nendrdwT1ea--ata33cedd11raom44isi11ennCeadiiot0ssCcttd3rr0uiia0arnn,ttiiinAdoogui1nnvs5d0st,aigigyrirlsooil1uuee0ppnd0ss,..tawha5trt0e,oeCCrsroosnn2hwcwc5eueurrrro1eerr8reeonnpp1ftrtr0eesgcscmeoeeognnsnn/tttttkrargootw/wllidiioattnyhhaa.nnbiibbymonoatatTohlhlhrseearsglrerddoooouvsswippeeenseddrt..eubaaatttAAwiLloC0Lolnsets mw"TaTeihhineteetihkhmcaralaaaFbsblbbossiiowyyttrerressriiennggvwieeeendrroeesa+aennddhdhtoeoumudrrspsuuueeerbbdrdibbaneetgrriAunnrddccdeaiaaiyvttvsahiheniedttdu6ceeaurrlhtlluhyymuurissodiiiuiinnnnggtghyhBaaaa1nnc8ggocciionoonnftnnggsrstiogaalssennlttstteaatdiianntddllriooeoeossossenemss.vbvysoosltleeuMoucearmm)lraeeilnccooaaaffiggneetRI1ssuamm~Blwiwab/itkitktiehgho..nCiwhiorwree CmacnCoeynyimscdclmhleieww..naafattlteeorirAoAolrInlsvweerrafaieeonnnriimnaaaaaavvlbiaatsnsiieollmravawpmbebeealrlrrleeeeatuaocaodlrdbbiessnlieeiirab~cbvnieaiedcltdduuhnmdsud:.iamagiiinlldayyiTT.thheeyffrrRoolcLommiiodggnyhhdtdttaarssvyyoeliwlw33geeeoohrrdffeetsroooggvnoneemess.rt&tasaatt11ii2rP2ooeunncrhhoooiurunwurrdaneetidiilRlliagogbhnhbctisdt/dadeayCrrshkkow3, K5It5A,lne7ilcr5lm9,,uibsdn1uuiarr51tnvv2,,igiiovvnii111nn055,g,gsfoarac11non86intamtnbaaeaannnnlloddtsarsm22.awv59leerrooweeffacsleigsgnueueeitstxschchataaamaalntintaineioetcosndiniigzzneeaassddnna.ddmooenntdthBhiegeoagdeceysesFrtltaawyaBabecbtbiLilitgttooohssnntasdsllevwteewerdraereasarmyyeiddno2o2e9r9sseeecddaaionnfrdaaadctcechcesdeoaoarcrcdhdhoaiinnnnwiuggemtdllaeeaylyrry..ussstw,,i3,e pirncelgumdainntg its contents, was examined immediately to determine if the animal was pregnant. Resuits ane biscusston Results and Discussion Eire Group of premant Rabbis (300, 150, 100 ox ma/ke/day F-3141CeC) First Grou~ of Pregnant Rabbits (300, 150, 100 or 0 mg/kg/day T-3141COC) hCrTEeehieensruueoloirrtsSaaeellddoaaiinddndamnyiiccennooidmmossppfttoorruuaadnnttoddiis--ooirrnnneagllsaooffc~(eeaddTTb--l33dde11ee44aa1u11chCC1hseOca.CC aAatLtAALlLlLddoo13ss350ee000ss0maomomff/ggk//aka33s0gg00d0//,,addyaeyy11s55a0r0TbaaobobbibrFbtiiett11ss0000diddsmeiiysgee/d/dkwkwsigwi/t/iSdhtdhheiaiiyynnnthStehhee tCcEffaaioiuZrrrmlssmpnnttiolnunatnn fatwodtoeuedrdwadosoadnno yasyvshtehoreeyfoffdSiAoEdoffsoxteisiThhcinng,gddt.aao(yyTpaoMoTrbffheldeegnddaooi~Inswr).toiinnggfisaAuvblasrbftlvietiieetv1nrrei5n0ggSaftmooguu1Trr/l0ok0nergvrmma/eaglbdbasb/baiiykktcgossf/radaahahb1yayb0ddi0trrsaoaaallbb/Erbbdveeiiigaette/dsdsddyyewwvydiedeitirreehaeeddin:.nd Thethe The Hcoimnpeoru.nd wTahes evemrlytitonxgicdetsothparegoncacnutrrerdabbriatpsidatenoluegvhelstoopfre1c0l0uameg/kbogt/ydawyeiagnhdt higher. The resulting deaths occurred rapid enough to preclude body weight 2~BaRniikxneerr EExappeerriismeenntt No. No. ostimON 0681RB0331 -- FC-143 11226644..00000033 au_noteo1T72 3M MN01691772 - 2 eUefsffefeedcctitsns,, `tcchlleiinnf~ii.rccsaatll sgsiriggonnusps oaafnnddprooeffgctenenanntnneerccarrobopbpissytys ff~viennrddeinng0gs0s.. hiA~gL1hL otofof tbtheheetoddlooessreeatlleeedvveellss ddudoususrerdeiindngg~antaa. "trlrhaoaewbbebfbriiirttscottteserprgaoartoutonuoldlpooggolyyefvepsslrttsueu.gddnyy.a. nt Therefore, a rabb~s were Therefore, a second group too high to second group ofbe of rabbits was tolerated rabbits was dosed at lower compound levels. SSeeccoonndd GGrroouupp ooff PPrreeggmnuanntt RRaabbbbiittss ((5500,, 2255,, 1100 aanndd 00 mmgg//kkgg//ddaayy TT--33114411CCooeC)) hrTeheesulootrraallinaaddcamoiiannpiiossuttnrrdaa-ttriieoolnnatooeffd TTd-e-a33t1Wh44s11.CCOECCOaantte dddooessaeetssh ooiffn 5t500h,,e 20255Bogox/rXa11/00dmmaggy//kkGggr//odduaapyywaddsiidddunnoeott. ort0obesseuaanrnlvteiIdnnitntuuinbbcaaotttmiihpeooonnusnteedurr-drrrooyerr.l..atOenNdNeoo ds2se5iiagtgnhnasssn.dooffonOeeeniiett0hhdmeeegrra/tkahagbb/oodrrnattyii~oohnneraoob0rrbimtgrr/eeksseogoarc/rhppdttaiiyhooanndgrwnwoeeeurrcpeerowpassy due cofFoiibmnnspddeioirnnuvggnessdd ooliffenvaae~bblhooserrttbsiietoocunnvdey.eoonrr Orrdaeneysessoorr2pp5Sttiiixaoonnnad,.ndonAAneinbb0eoodmdyoygf/kwweeggii/eggsdhhtettaytillroooanssb.ssbiotocTcchceueuarrcrrhleeoddshsadiinninnaaellcbilrodoytpthshryreeee wwZceeaciib~ggbphhiotttusndccooveiilrnneeccviiedoldfesefddbwwefiitettawhdhe.encclliiTdnnhaiieyccsaabllosdixsysiiggUannenssidgohonfftineeeciihttoahhfneegrregsennsoootfaootrri4o1n1ff.euwthrssTttehooeeoollclssoosmsipinondudiinnicdcaabttoliidennyvggalstthhee b5bre3eatt/bwvkbeegieet/nnsdadydwaaeyyrgsserosuosiifpxxf(aaTfnnaeddebdl.enniinn2ee)T.hooeffTbhgogeeedssyttcaaowttmeiipiooognnuhntvdwee-crrtheeraenagssetiiseggdnnoiifrffiaicbcaabalnilntttlsltyyhrrededcieioffvffceeeorrrmeeepdnnottufnrdfforrnoolmmevttethelhhsee 00 mgiignen/iisetktidagaat/llidoanwyweeiivgggerhhrotteupllgooa(ssiTssnaibnlccgeaauunss2eeo)dd.rebbyybTohcdecoyommcpwpooeomuuipnngoddhutnaadd~t-ahntaiirnnneiiatssthtteerrdaa0ttriiamoobngnb/ikatasgnnd/ddrabbeyyycodvdgaareyoyruepd11.88foorffom r_he gestation were gaining more body weight than the 0 mg/kg/day group. Ccoonncclluussiioonn hsTtheuedyoobbvjjaeesccttimivevece ovofifthddeetttheeerrmmisinenicinongngdaanngrouuupppppeeorrf ddoorsasbeebillteesvv.eell Tffhooerr araennsuoolrrtaasll srruaagbbgbbeiistttttetehrraaatttoolltooheggyy 3ts500eturndmaygtgo//lkwkoagasg//ydaamyyesttudddoowysisetehbellcteeahvveueesllesewvacooouunlltdddoxigbbceeroeuaafpnnfaoaacfpptpprrrooaofbppbrribii~oaasdtt,yee hwheiiTigghghehhtrddeoossslueeolsetiisnnocasacuugrrrgaarebbesbb~diitttinha~thethe taabebssreeanntccoeelogoofyf scctooummdppyoouunnbded-c-rarueeslleaatteeaddtoddxeeiaactthhise..ffect of body weight loss occurred in the 11226644..00000044 3M_MNO1691773 3M MN01691773 co a 8, N EME 3s jg ooo $888 FERS i P 0 0 0 0 cose iP ao ee 0 ~ 0 0 35 Bgl g 2 ece cee 0 0 0 0 LI i 32 feo on oo oo 5 ol % on so oo : ooo no cone 3i 0 0 0 0 Ne won ooo fi .W ,-~ 0 0 0 of oo ot oo oo i 0 0 0 0 s Ed sag 3] d &E F- s838s%s feFE gi$e3wd5z 3i35i nt 11226644..00000055 a uore17s7 3M MN01691774 - : ". Table 2 Bral RangMeafainndeBrocyStWuediyghotf GTa-i3n14o1rCeLCosisn Rabbits oy 6 5 12 1s 18 23 mSaT/AxN.s/tDaEy V 41.216 25.14445.36145.S66342.43 951.574 0SmTaA/Nk.a/DlEayV 16.467 37-.g4g52.283 85.35696.S95 452.139 8 SmTAGN/. 8aDyEV 15.36410g5.os4t118.-17 76.g4e 47.713 9211.35 10mSTgAN/.dDaEyV23.g6q62216%25.10272135 20.357 62ase7 2 significantly --Significantly lloovweerr t~hhaann t~hhee ccoonnttrrooll ((DDuunnnneetttt''ss &t tteesstt p p << 00..0055)) 11226644..00000066 3M_MNO1691775 3M MN01691775 - . s. ut ringer sptusntofsa1 tc ta ratbics Oral Rangefin~er Study of T-3141COC in Rabbits ET aa kane to) a rs soy sees Individual Body Weights (g) and Mean Body Weights A With Sta.,x~t,rd Deviations EEE 3 6 EEE 9 12 15 18 29 o nooo LmNNMEEW mBEoNREeASmEZE2mnaEIIsSNRnEIeRlNeEInoeRRd EEaeRNd0IsEeNndRonEEeeNd MWEaRsLaE NIB 2149 2177 NIB 2158 2469 NI8 21~3 2457 mERmEaSnEmRmIaNnana 2127 2180 2278 2709 2319 2362 2495 2516 2585 2704 2687 296 251! 2522 2522 2615 2636 2881 srevenoer32sSaateaahaaiisasnesSaAeRs A2028 as6S ow 3s 5 sm 1s 1s =m DRV 3 6 9 12 15 18 ~9 | 20o01i8ra2311s55s:a13n5376%5 250386 1350755 sSospo 1H32B0 1U70S0 z029 0tB 2152 2574 2632 2589 2627 2622 2707 2955 o1k8 aEnEEnEsaannaETnBaRNIINnEIS OtB oh ER ER ENERERIN EN LS OtB Bn EREREIRRERERIEE 0tB 2154 2165 2t66 2118 2523 1878 216~ 2588 1891 2110 2545 1821 2029 2595 1889 2204 2685 1981 2299 2?56 199~ 2463 7e29 2162 || orevembelztnsizaa2057 2aseRsEuasE2S70Ases ST/IN. 2279 2726 2257 22~e 2~15 2770 2589 DEY~22. 4335. 5729. 83~?. 5355. 2417. 943t. 11226644..00000077 sucons 3M MN01691776 . 5 --MNop~ednitixx Tx ((CCoonncclluuddeedd)) nO~grriaavllidRRuaaan~lgeeEBfioindn~ydeeWrreiSSgtthuutddsyy I~uLividual ~ ~y Weights oo((ff5g)) TT-a-ann33dd1144MM11eeCCaaOennCC ~ BiinondyRyRaaWWbbeebbiiiiggtthhssttss WWfi~thh SSttaannddaarrdd DDeevviiaattiioonnss AY. DRY 3 3 66 5 12 15 18 25 9 12 15 18 29 2255 MMGG//KKGG//DDRAVY PPPiiLBBB 222111555565 112991220990 211199477122 121991080332 112991550113 222618048828 222180655455 222422388866 PPPPILiiBBBB 2222111155557766 2211171742829585 1212727151543631 112i751?128i5725 1221766184881135 i112977148041772 2111198866114466 2222028430357%78 PPPPi1ttBBB8 2222111166657887 2222098t48089008 2222058292918688 2221678972721717 2221098716144145 1112599976473213 2121101925281114 2322303236983735 PIB 2168 2988 2926 2727 2981 2982 3851 3887 STANMM.EEARNNDEV3S22S11.44773522711.883383422608.774444322580.6666S4422211226674322511.999922622244.1111 STRN. DEV399.8397. 8348.4439.5442.7435. 2362.6 ov 3 6 5 12 1s 18 25 DRY 3 6 9 12 15 18 29 1180MMaG/kKaG/DDRRYV 001188 22211t565905 121616929339 112727404666 112770665656 121707747225 111980532144 t11869776999 222820280299 004188 2222111166661218 2112818104824143 2121282622821565 2211198846451188 1212628840444049 1211829897587117 1211539932363089 2222151253523232 0@118B 2222111166672950 2222155048881558 2222162623331850 2222616121260788 2222661280783358 2222255243742312 2222355229938557 2222664563609290 2t78 2688 2135 2117 2175 2233 223? 2488 STANMM.EEARNDNEV31220087?3343122711.227773022108.996352922611.807702722311.220812722711.556662222832.44443 STRN. DEV318.4317.7381.8298.8275.1277.6228.2 11226644..00000088 3M_MNO169177T 3M MN01691777 DreyRTIO 10 nr cane EM..GG~.'.. GGCooarrsttennocrr ((o,rrd~aqiinneadl ++ 1i)) . E.6. samrecnt W~e. CG.~ MLaemoprraeiochht + . D. GRAfEith + P. A. Wel (5) W. C. McCormick F. D. Griffith F. A. Obel (5) 11226644..00000099 _MNot691TTS 3M MN01691778