Document 2RQv1rZayeNyJ2Z9Krawr2qNL

CONFIDENTIAL WORLD REGIS TER OF CASES OF ANGIOSARCOMA OF LIVER (A S L) THE REVIEW DATE 1 JANUARY 1938 **&*#** Collated by: Dr Brian Bennett Occupational Health Department ICI Chemicals and Polymers Limited Hillhouse Site PO Box 4 Thornton-Cleveleys Blackpool FY4 4QD England (Telephone (Telex (Facsimile 0253 861632 ) 67483- ICIPLHG) 0253 861861 ) GENC 006071 LIVER ANGIOSARCOMA GASES OCBFTEEfTIAL FEBRUARY 1988 CIRCULATION OF REGISTER BAGSHAW Dr I MM BAND Dr P R BARON Dr C BARRAT Dr G BAXTER Dr Peter BAYLAC Dr BEAUPRE M BELLEC Dr 8ENECH Dr M BENNETT Dr B BERTAZZI Dr P BISHOP Dr C BORRELLI F E BOYER R W BRAUN Dr C L J BREWER Dr M BRYSON Dr D D BURGESS Mr David BYREN Dr David CARTER Dr J T CAIAfEARITI A CELLA Mr C CHANCE Mr M CLARKE Dr E A CLAUS Mr P G CLAYTON Mr H OONTASSOT Dr J C DAVIES Mr J G DEJONG Dr G DELORFE Dr F DEPLAN Dr DE VOS Mr A J DIETZ Dr H W DOLL Sir Richard DOMBROWSKI S L DRIMWRIGHT Dr J R DUPONT Mr G EMONGER Mr H ERNST Dr W EVANS Dr A E J FALK, Dr H FAVRE Dr FERGUSON Dr D M FDJCHAM Ms Shirley FORMAN Dr D FRASE R W FRIEDEL Dr H P GOSZTONYI Jnr Dr GOTTESMAN RT HARRIS Dr W D HENDERSON I B HILLMAN Dr D W HINDERER Dr R K HOWARD Or JK HUMPHRY Dr N F JAUVERT Mr J JERVIS Mr H R JONES Dr R D Norsk Hydro, Newton Aycliffe, UK Cancer Control Agency of British Columbia, Vancouver, Canada ICI ftmcorn, UK AECRP, Conmentry, France University of Cambridge, UK Atochsn, Chauny, France Government of Quebec Cancer Registry, Canada ffrione Poulenc, Aubervillers, France Naphtachimie, Lavera, France ICI Hlllhouse, UK Inst of Occupational Health, Milan University, Italy EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Formosa Plastics, Delaware City, USA Akzo, Arnhem, Holland Inperial Oil, Sarnia, Ontario, Canada ICI ffillinghan, UK ICI Americas, Wilmington, Delaware USA Kemanord, Stockholm, Sweden EMAS, tendon, UK EVC, Brussels, Belgian EVC, Brussels, Belgium ICI ftmcom, UK Ontario Cancer Foundation, Toronto, Canada APME, Brussels, Belgium Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fons, France ICI, Everberg, Belgium Shell, An Den Haag, Holland Quebec, Canada Atochan, Jarrle, France EVC, Vfelwyn Garden City, UK B F Goodrich, Akron, Chio, USA Inperlal Cancer Research Find, Oxford University, UK Dow Chanlcal, Midland, Michigan, USA Vista Chemical, Houston, Texas, USA APME, Brussels, Belgium VKE, Frankfurt, Germany Berufsgenossenschaft der Chaulschen Industries, Numberg, Germany Lever Bros, Warrington, IK Chronic Diseases Div, US Dept of Health & Rman Services, Atlanta, USA Atochem, Montluel, France ICI Anericas, Wilmington, Delaware, USA Alberta Cancer Board, Edmonton, Canada Inperial Cancer Research Rind, Oxford University, UK DiversiTech General, Akron, Ohio, USA Berufsgenossenschaft der Cheidschen Industries, Heidelberg, Ganany R E Tenneco Chadcals, Plscataray, New Jersey, USA The Vinyl Institute, tfcyne, NJ, USA Uniroyal Inc, Middlebury, Connecticut, USA ICI, Hlllhouse, UK Dianond Shamrock Gorp, Dallas, Texas, USA BF Goodrich, Cleveland, Olio, USA University of Otago School of Medicine, Wellington, New Zealand ICI Australia, Melbourne, Australia Chloe Chlmie, Paris, France ICI MLllbank, Loudon UK EMAS, Bootle, UK WPX/ASL - ASL ADDRESS,! 004.072 qehc KATPEKT Dr J H KARRH Dr Bruce KLEIN Dr H KREUCER Dr R A LAGAST Dr H LALOINE Dr J P LANHAM Dr John LANOUZIERE Dr UWRQJCE-JONES LEE Dr F I LELBACH Prof 14C LEVEQUE Dr G LEVTSON Dr D A LEWIS Dr P LDLIVLtK Mr LUSS R D LUSSATO Dr Josette MAILLARD Dr J M MALTDNI Prof C MARGETTS, Mr R J MAITRE Prof lo MATTIUSSI Dr R MIDOLEION D MOKKA Mr MCNTESANO Dr R MDm Dr A A MUNOZ MUUICN Dr M MacSWEEN Prof RIM NAKAMJRA Dr S OLSON H G OWEN Dr R PADDLE Dr G M PAGLIAUJNGA Dr S PAQUET Dr PATERSON Dr J C PIRASTU Dr Roberta POPPER Dr Hans POSSBERG Dr J PUECH Dr A M PURDHAM Dr J RAMBAUD Dr J RICHARD Dr P ROBSON Mrs D RODRIGUES Dr KJF ROUSH Dr G RUTY Dr J SALG Dr Joy*;e A SARAOCI Dr R SCHEFFERS Dr T M L SCHIPPER Dr H SERONtC Dr D SHAH Dr Has SIGRIST Dr J SMITH Prof Allan H SMEIH Dr E SMITH ft J S SMITH Dr P M SPIKEAS Dr R SIAFFOK) Dr J SXAHNEOCER Mr SULAIMAN Dr 2- - Dow (hsnical Europe, Horgen, Switzerland Cupont, Wilmington, Delaware USA Dynamit Nobel, Troisdorf, Germany BF Goodrich, Akron, Chio, USA Solvay, Brussels, Belgian Solvay, Brtssels, Belglun Dew Chemical, Midland, Michigan, USA Solvay, Thvaux, France Sir Christopher, Chief Medical Officer, ICI, London UK Victoria Hospital, Blackpool, Lancs, UK University of Bonn, West Germany CDF Chimie, AZF, Bully-les-Mlnes, France St Bartholomew's Hospital, London, UK Chemical Industries Association, London, UK Solvay, Brussels, Belgian Occidental Chemical, Pottstown, Pennsylvania, USA Atochen, France Suva, Luzern, Switzerland Institute di Qncologia, Bologna, Italy ICI Directorate, Wilton HQ, UK ffedil-Anlc-S, Milan, Italy Montedison, Milan, Italy Norsk Hydro, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France Duperlal SAIC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain western Infirmary, Glasgow, Scotland Japanese PVC Association, Tckyo VC Safety Association, Louisiana, USA Trades Union Congress, London, UK ICI Central Medical Group, Alderley Park, UK Montedison, Novara, Italy Atochen, Serquigny, France IQ Runcorn, UK Istituto Superlore di Sanita, Rcme, Italy Mount Sinai Msdical Center, New York, USA thdcer-ChsnLe, Mmlch, Germany Atochen, Brignoud, France Canadian Centre for Occupational Health & Safety, Hanilton, Canada R? Recherches, Antony, France Phone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada ICI, Sao Paulo, Brazil Monsanto, St Louis, Missouri, USA Atochen, St Auban, France NIOSH, Cincinnati, USA IARC, Lyon, France D31/CVM), Geleen, Itolland University of fterdtoba, Winnipeg, Canada Diamond Shamrock, Dallas, USA CMA, Vhshington DC, USA Shell Chimie, Berre L'Etang, France University of California, Berkeley, USA Division of Envircnieutal Health, World Health Organisation, Geneva, Switzerland ICI Hlllhouse, UK Llandough Hospital, Fenarth, UK NCI/NTH, Bethesda, fhryland, USA Somerset, UK BASF, Ludwlgshafen, Germany Arabian Petrochemical Co, Saudi Arabia WPX/ASL - ASL ADDRESS,2 GENC 006073 -3- TACHECI Dr H TAMBURRO Prof CH ten BEKZ Dr W F TEUKHOFF Dr N TEPPER Dr L B TER HAAR Dr Gary TFRWIESCH Dr B THERIAULT Dr Gilles THIESS Prof Dr A M THIIS-EVENSEN Dr E THOMSON Dr D H TONER H P VAN DER MERWE Dr H J WALLACE J R WALTEMA3E H WEJDLING S 0 WHITE K H WILINSKI 0 wnilAfE Dr CMJ WILSON Prof R WRIGHT Dr A P YORK J Hoechst AG, Frankfurt, Germany University of Louisville, USA D31, Geleen, Holland fills AG, Marl, Germany Air Products, Allentcwn, Pennsylvania, USA Ethyl Corporation, Baton Rouge, Louisiana, USA Giemische Werke fills, Kreis Recklinghausen, Germany McGill University, Montreal, Canada BASF, Ludwi^hhafen, Germany Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa Esso, Sarnia, Ontario, Canada BF Goodrich, Cleveland, Ohio, Usa Norsk Hydro, Stenungsund, Sweden Duperial, Buenos Aires, Argentina Electrochsiical Industries, Acre, Israel EP Chemicals, Penarth, UK Harvard University, Canbrldge, Efassachusetts, USA ICI Wilton, UK ICI Everberg, Belgiun From: Dr B Bennett, Occupational Health Department, ICI (hanicals & Polymers Group, Hillhouse Site, PO Box 4, Thomton-develeys, Blackpool FY5 4QD, England WPX/ASL - ASL ADDRESS,3 GENC 004074 4 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVEN DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1988 PREFACE: ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The 8 new cases in the Register are the following: Canada 11 and 12; France 22; Italy 06; Japan 03; UK 19; US 4o and 4l. 2 There are amendments from the previous Register against the following cases: Japan 01 and 02. 3 I would like to thank the following for informing me of new cases: Dr Delorme, Dr Contassot, Dr Chiozzini, Dr Nakamura, Dr Evans, Dr Williams, Dr Dietz, and Professor Tamburro. 4 For the case corrections I thank Dr Nakamura. 5 It will be noted that there are gaps in our knowledge of several cases, notably Canada 11 and 12 and US 91. Also, so far as we know the following people are still alive; cases Canada 11, France 15 and 22, Germany 31 and 32, UK 14, US 33, 36, 4l. Is this correct? This is important information for the industry world-wide and we would appreciate news. 6 I should be glad if all recipients of the Register would continue to keep me fully informed of any new cases, or give the name and address of someone who can give me the necessary details. I have again attached a blank sheet at the back of the Register so that information can be supplied under the appropriate headings, so far as possible. 7 As a result of the request sent with last year's Register, regarding Co-factors, we received a great deal ofinformation about PVC Plants, which has resulted in many amendments to Tables 8, 9, 10 and 13. Further corrections will be appreciated, bearing in mind that' the Tables are confined to PVC. 8 RESEARCH: (a) May I again ask that all individuals involved in relevant research keep me informed and if possible send me reports. Perhaps recipients of this Register would pass on my request. (b) Co-factors: In response to the questionnaire enclosed with the 19&7 Register, regarding possible co factors with Vinyl Chloride, I received replies from 26 Companies, covering 61 factories. This material is now being analysed by Professor Carlo Tamburro at the University of Louisville, Kentucky, USA, and we shall report on the results as soon as possible. We are extremely grateful to all who took the trouble to give this information. If any Company has not yet completed the Co-factor questionnaire I should be grateful if it could be completed and sent back to me as soon as possible. 9 I would also be glad of help to keep the mailing list correct and up to date, with news of retirements, etc. FROM: Dr Brian Bennett, Occupational Health Department, ICI Chemicals and Polymers Limited Hillhouse Site, P 0 Box 4, Thornton-Cleveleys, Blackpool, FY5 4QD, England February 1988 bti/BGS SEliC 006075 Index Table Sequence Belgium Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases per annum (Table i) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) Distribution of Latency Periods (Tables 4B-4H) Annual Geographical Incidence (Table 5) ICI CHEMICALS & POLYMERS WPX/ASO - LANGIOCASES,4 LIVER ANGIOSARCOMA CASES (REVIEW DATE - I JANUARY 1988) | Page Page 1 ASL Case Numbers by year of Death (Table 6) 2-3 ASL Case Numbers by year of first exposure 4 (Table 7) 46 47 5-9 10-15 16-17 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) 48-49 50-51 18 Canadian PVC Producers - Start-up Dates vs ASL Cases 52 (Table 10) 19 East European PVC Producers - Start-up Dates vs ASL Cases 53 20 (Table 11) 21-24 25-32 33 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) 54 55 34 Australasian PVC Producers - Start-up Dates (Table 14) 56 35 Middle Eastern PVC Producers - Start-up Dates (Table 15) 57 36 Blank form for notifying new cases - 37 38-44 45 6ENC 006076 Page 1 HKLGUIM JC1 CMt-ttl CALS 6 PGLYHEKS LIVER Angiosarcoma Cases - {.Review Date I January 1988) UPX/ASL - LANC1QCASLS ,6 COUNTRY AND REFERENCE NO NAME OS INITIALS DATE OP BIRTH FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL COMF1RNATION ESTIMATED EXPOSURE LEVEL I OTHER | OTHER CAREER | COMMENTS HIGHLIGHTS | ___________L;__________ Soluay 00.05.76 Solvay Jeaeppe 29.06*76 High Autocleaner 14 yra 1958-I960 expoaed to polyworker 200 ppn 3 yra for 8 hrs per day and certainly unde r 500 ppa in b to autoclave 1968-J972 exposed to 50-200 ppm 8 hra per day In 253 autoc Laves 1952-1974 expoaed Co 50-200 pp In auto* clave rooa 1974-JOO Pi* 1975- 50 Pf* RETIRED 1 Feb 1975 Driller In IHepatlc teata foundry |1n Oct 1974 (2 yra) {were noraal, Fa raer | Ret l red I! 15 yra) IFeh 1975 Work In glass IHoapltsltsed lnd. 6 cheat- |May 1976 cal industry | IConpiete |Cllntca1 Snd |ca reer detalla |are given In a Ipaper by IHublet er al JIn Arch, Beig, |Hed, Soc., lHyg. Hed. |Trav. hed. I Leg. 11977 pages (601-622 I I 08.62-03. 63 01.67 -10.71 * 200 ppn 8h/day OA.63-12, 66 < 200 pfW 6El 1C Au toe leane r 5 yra 5 atha Operator 3 yra 9aths. 00601 I FI reman a Ince Mat a ign July 10 71. |7 9 : Thoracic |pa In 07.79. (Hepatic teats |a Uered 10.79. |PosltIve lechog r aphy (11.79. Heps- (feciimy (12.00. (( heiaol henpy. tlnforautIon Iglven in 11e ft it 12 Nov ||984 Ij ma Dr Hr Page 2 CANADA Sheet I LIVER Angiosarcoma Cases - (Review Dace: 1 Jan I960) HAY - MONTH - YEAH HrKf AI>L - LAhlj IIJLrtbtJ , 1 COUNTRY AND REFERENCE NO CANADA 01 02 0) 04 05 06 07 06 09 2 i3[ NAME OR | DATE OP INITIALS | BIRTH |15,12.n 106.03.14 (26.08.19 (05.04.19 107.05.H i 15. 12. (9 109.11.(9 113.05.20 119.07.21 1 4 (5 6 COMPANY ! 1 1 ( FACTORY FIRST VC EXPOSURE 1 1....................................... .... 1 SHAWINI CAN ( 1944 1 1 1 ( 1943 1 J t t 1 1941 t ( 1 .............................. 1 1 1945 1 1 1 ! i I ' 1944 I I 1 i I 1947 I 1 1 l ( 1946 i l I 1961 I 1 ( I 1946 1 i t 78 ! 15 9 ID 1 H 12 13 I 14 1 lb _L DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS _L 1955 41 1 YEARS OF | DATE OF EXPOSURE 1 DEATH HISTOLOGICAL CONFIRMATION _L ll 102.09.55 Yea ESTlMATED EXPOSURE LEVEL 1 1 ( OCCUPATION 1 1 1 |Reactor |c1eaner 11 1 I OTHER | OTHER ( CAREER ( COhHE NTS J HIGHLIGHTS 1 11 11 ( (Operator 1 |Smoker |polymer last Ion | Xi J______ ... 1 11 1957 43 14 14 121.12.57 Yea |ha 1nc enance |Operator | Worked 1*11Iwrlght , | (overtlae (pipefitter * | Smoker 1962 42 21 20 123.03.62 Yea i (Operator, (foreman 1 1 1 1 ( Worked |overclae | Non-saoker 1967 46 22 22 121.01.66 Yea jX 1968 57 24 05 (05.07.66 Yes j X 1971 51 24 21 |(0.04.71 Yea 1 1 | Reactor (cleaner 1 i 1 (Reactor (cleaner l 1 (Reactor Icleaner 1 i 1 |Operator, |foreaan. t Worked |overt Lae Water cooling |Saoker (unit i ; Ji Water cooling Worked (unit |overtlae t |Smoker 1 t (Maintenance, |alllvrlght 1 | Worked (overtime |Smoker * 1972 l 51 l I l 1973 l 53 i i l J 974 l 51 i * f ( 26 i \ 1 1 12 l _L 1 i 2H l i t 25 124.12.72 Yes 05 112.06.73 Yea 26 1 i- !1 104.09.74 *l j____________ X Yes X J _L i (Reactor |c leaner 1 1 | Reactor |cLeaner 1 ( (Machine shop (operator and Ipoly unit 1 ( (Maintenance laachlne a hop 1 (Worked | owe rtlae |Saok e r 1 |1n pi ant |2 5 y ra! Saoker 1 j Furnace op. 1 Iplpefltter 1 |Maintenance |Worked Invert lae |Sank er j________________ j___________________ j___________________ * Paper by l>r F DEI.OKHb. lit Anita lea d'AitAtnnle pa t ho I og l<|tie Parle, 19/8 Vnl 21 No 2 ppl05-114 cl&litm tills case had both a hepatoaa and ASL simultaneously. GENC OO.ifi?g Page 1 CANADA Sheet 2 ICt CHEMICALS & POLYMERS LIVES Angiosarcoma Cases - (Review Date: I Jan 190ft) DAY - MONTH - YEAS All dates use UK system WPX/ASL - UkNClUCASLS.a COUNTRY AND REFERENCE NO CANADA 2 NAME OR INITIALS 11 4 1 5 6| 7 DATE OF | filJtTH | COMPANY 1 1 1 FACTORY i 1 FIRST VC 1 DATE OF EXPOSURE | DIAGNOSIS Shawlnlga 8 ACE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE 1 DATE OF 0EATH 12 j n * 1 HISTOLOGICAL | CONFIRMATION | 1 ESTIMATED EXPOSURE LEVEL 14 | IS OCCUPATION | OTHER CAREER HIGHLIGHTS oo.oA.n Reactor Furnace op. cleaner maintenance packaging ----------------!IL lb OTHER COMMENTS Ex-sacker Letter from 0c Fernand Delorme, Pathologist 20.09.14 Shawlnlga Mar 82 Letter from Dr Fernsnd Delorme, Pathologist i SEN'-" Ij 0 *0 7 9 Page 4 CZECHOSLOVAKIA IC1 CHEMICALS A POLYMERS LIVER Angloaarcone Cases - (Review Date: Jan SB) WPX/ASL - LANGIOCA6ES.9 COOSTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH FIRST VC EXPOSURE C2ECHOSLOVAKIA 01 02 1 | ( t | 1 1 1 1 1 1 | 1 1 1 1 I2S.06.28 1 1 1 i ! I 106.07.27 State Co State Co 1 1 I \ i Movafcy i t 1 1 1 1 ( Novaky 1 1 1 1 i 0I.07.S7 1 I 1 \ 1 1 01. n. so OATS or DIAGNOSIS AGE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE Of DEATH 1 i t 1 24.12.73 1 45 16 J 1 1 I _t__ ! 1 27.11.64 J 37 14 11 11 ii 11 1 16 124.12.73 1t Il 11 11 1 __l 11 1 15 (26.11.64 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL I OCCUPATION 1 I OTHER CAREER HIGHLIGHTS 1 1 \ 1 Yea | t 1 1 l 1 1 Yea t 1 1 1 |Autoclave iCleaner 1 1 l 1 ! l |Autocleve Cleaner 1 |IARC letter 1 | I of 1-4-82 | Iglvlng details} (fro* Prof | (A David of (Centre tnd (Hygiene and | | | (Occ disease*. | 11 11 |[ARC letter of | (J-4-82 gave (soeedhat lalcered He tee Jfor thla case. 11 have leccepted the |change* a1nee (the date* coae |fro* Prof |A David of the (Centre of |Industrial IHyglene and IQccupat(onel (Diseases. My Idatea cone (originally |froe NIOSH. j____________ OTHER COMMENTS GENC Ij fl Afi or, 5 PRANCE Sheet I ICI CHEMICALS POLYMERS LIVER AngIosarcoaa Case* - {Review Date: | Jan 80} UPK/ASL - LANG I OCA S S. 10 1 12 11 COUNTRY AND | NAME OR J DATE OF REFERENCE | INITIALS 1 BIRTH NO FRANCE 1 4| -J i 5 1 COMPANY j FACTORY 1 J______ 1 1 01 |M j 02 |SIM j 01 INAV J 04 4 HO* j 05 jB |15.04,24 tP 101.06. 11 PttJK ji 106.01.20 RF j (27.01.27 PCl/K j t24.oi.ia PCUK |Route- j 11Ion 1 1 1 J______ 1 j Brignoud 1 1 1 4 t 1 J* t St Font 1 1 1 1 \ J \ JBrignoud 1 1 1 1 1 1 J 1 jBrigooud 1 1 1 1 1 1 i 1 1 1 1 67 FUST VC EXPOSURE DATE OF DIAGNOSIS 0O.OL.46 IS.02.67 06.07.54 15.01.75 00.00.46 15.01.75 i 14.10.44 16.01.76 IS.01.65 11.05.76 H 4 10 l 11 AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF | DATE OP EXPOSURE J DEATH 41 21 14 114.02.67 1261 16 I24.0J.75 55 24 24 129.06.75 i -L j 44 26 26 104.01.76 1 IB IJ JJ (13.05.76 t. 12 HISTOLOGICAL CONFIRMATION Yea Yea (N10SH no couenc 1 Yea Yea Yea n4 1 ( J4 t 15 l 16 1 1 ESTIMATED 1 1 EXPOSURE | OCCUPATION 1 LEVEL 1 I OTHER CAREER H1CHUCHTS 1 | J OTHER COMMENTS i1 1 1 High l |Autoclave (worker and jcleaner |Ref. Ravler ec |al Arch. Hal. IFrof. J 30 n"* 119 yr (1 Nov 75 ( Ip 171-17? High 1 1 (2 yra on |Bonoaer 110 yra on jpolyaer- |iaatlon lUihtn Jorlgln 1 IRef. |G Bonne ton et |ai "Nouvelle |preeae jnedlcale'* J 15 Nov 1977 1 Ip 735 High 1 1 j Polyworker j10 yra a 1 Jf IVCM product loot Ref. Rety et 116 yra |al Arch. Hal. lautoclave Icleaner |Confounding 13 yra (Italian PCW J Shepherd, (Sawyer, Maaon IFrof. 1 17 |6 June 7? Ip 551-555 T High 1 ( IMononer (production |worker 18 yr. (PVC If titration 1 1 4 1 t 1 i IJ8 yr. 11 High 1 |t Poly worker DThoracotoay JRef. P Coudere 1 1 1 yra 1 1 t 1 1 (9th Feb 1976 let aj 'Seaalne Icoatal Idea hoep11 aux fangloearcooa 110 Sept entice 12)Sclntlgraphyj(976 ! found ASl. . 1Prtvl miely had |3>Uaenorrhege f bone l 1 ( f ron ASL |4>Rlght langl uaurcLiDu" J A1 e o \ iHepatectuay J PI 1J l huwajc 1 et 1 | a J "La Nouv e11e 1 jPrettHo Medicaid j | 7ch July 1979 iPsge 2^.65 Page b FRANCE Sheet 2 EC1 CHEMICALS A POLYMERS LIVER Angiosarcoma Cases - (Review Dace: I Jan 1964) WPX/ASL - LANCIOCASES,I l COUNTRY AND REFERENCE NO NAHE OR INITIALS DATE OF RIRTH FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS Of EXPOSURE TO OlACHOSIS YEARS OF EXPOSURE DATE OP 1 HISTOLOGICAL | ESTIMATED DEATH | CONFIRMATION J EXPOSURE | | LEVEL I OCCUPATION irlgnoud 1 2*06.7b U.09.76 | (N10SH | says | 12.09,7b)| < me-mu) 2 yra flit ration 10-li yra polyworker and works lab? OTHER CAREER HIGHLIGHTS OTHER COMMENTS I \ |Thii nan had |AOL p rlor t o |AS. Ann. de IMal. Prof. IJuly '7? Ip 645 A b. |AOL uta found |ln 197J five lyra before | ASL 1 07 |C1R 1 1 1 1 1 l on | R l1 126.04.27 | RP 1\ 1 I Sc Auban | 0 .07.50 | After i i 49 1 11 11 26 1 22 J02.07.76 | Yea i High 1 PI ant fore- 11972-6 edaln IDled of 11 11 | death i 1 1 1 (NIOSH no | |aan In laectlon In leeptlcaesls l1 11 J NIOSH i 1 1 1 consent) | |polyner- |St Auban |Snail Liver 11 11 1 i*Y* 1 1 1t 1 lleetion | lleafon found l1 1t | 00.07.76 I 1 11 11 fafter autopsy lJ 1I 101 04.54 | Solway 1 \ ITavaux i ___________ !____________ 11 l l 23.05 57 | 03.12.75 i 42 | 19 I 1 1 1i_________________ i____________ J1 11 11 1 19 110.01.77 | Yea | Moderate |6 yra packer| j__________________ 1 |Had been 11 11 1 I 1 1 11 11 1 i J J 11 1J 1 l 1 1 \1 i1 1 I 1 1 \1 11 1 \ 1 1 11 1 11 I 11 1 11 1 1J J |4 autoclave ( t Iclnr I 1 i14 yra J | lautoclave | | |worker | (tunnel worker (previously * \ ______ L_ 06.JO.14 11 \ ! J_______________ l 10.01.48 26.04.7b 1 !l 2S.J2.77 !--------------------------- !1 __________ !___________________ I Very High Polyaer- 10 yra In |Ope rated 4,7b 1940-J96b leatlon sulphuric |for reaoval of Leaser o pera t or. acid factory, Ituoour f roo Exposure sutocleaner, storekeeper A Jllver and L 966--1976 autoclave general Idled after atntenance services | second Jsurglca L loperetion for Iblllo Ibronchja I | f 1 a t Li I a |Paper by | Dr Ret y et al |1n Archives de |Halades | Profees I otra Is 6ENC 006082 |Yol 40 hu b Pane 7 FRANCE Sheet 3 ICl CHEMICALS L POLYMERS LIVER Angloaarcoaa Cased - (Review Date: l Jan 1966) UPX/ASL - LANCIOCASES , 12 COUNTRY ANO REFERENCE NO NAME OR INITIALS DATE OF R1RTH France 10 tottit FIRST VC EXPOSURE DATE OF DIAGNOSIS _L l ACE AT | YEARS OF DIAGNOSIS ( EXPOSURE TO | DIAGNOSIS _________ I___________ I YEARS OF EXPOSURE DATE OF DEATH HIST0L0C1CAL CONFIRMATION _L ESTIMATED t EXPOSURE | OCCUPATION LEVEL J 1 t OTHER CAREER HIGHLIGHTS OTHER COMMENTS 00.0l.4l I2.0fr.76 66 ~ir U.il. 70 High High (Autoclave (cleaner 10 yrs In aechanical englneerlng Industry 1946-1956 11941-1946 Ipolynerjtastton Igeneral |purpose | worker______ 11946-1972 | VCM |*ynthesls J(HCI 4 (Acetylene) J Foreman ((agent (ile ealtriae] | (972 Iretlred Died of pulaonary eabollsa 5 days after surgery _______________ i6.oa.i4 Brlgnoud 00.05.79 19.01.31 Solvay 23.09.63 26.06.79 15-04-24 Ch I oc < h Ini ' (Foraerly KP) no.07. 27 22.06.79 29.07.81 bEE-lu GO6OS3 High f Honooer |product Ion land potyner|1sat Ion lopetator | Autocleaner 13 yt., JAuto- (cperator (9 yrs, (CopoLyaer* | 4 yrs I I 2 yrs as cycl aechanlc. 10 yrs sa ensaellsr In snltsry ware asnufacture _L Very High |19(3-1975 1975-1979 19(3-1975 |Ali types of maintenance and 11obs on work [titerml t t-|*amifsecure tuilly | 6 *a 1 m t'liam'i 1975-1979 |1n VCM Poly ______________ lITocum Cigarette saoker until 1974. Ill all of 1977 due to Oesophageal varices. Surgical Intervention 25.05. 79 (right icpat cot nay) Page FRANCE Sheet 4 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF 81RTH 01.0l.37 Chic* Chlale ( formerly RP) 13.07.22 Chioe Chlale ( Foraerly RP) Chioe Chlale (Foraerly RP) Solvay ]C[ CHEMICALS A POLYMERS LIVER Angfoearcona Castes - (Review Date: 1 Jan J9SS) WPX/ASL - LANGlOCASES.I 3 FIRST VC EXPOSURE DATE OF DIAGNOSIS 07.07.5S 28.0S.S2 OS.01.S3 17,06.48 03,04.83 ACE AT DIAGNOSIS X I YEARS OF | YEARS OF EXPOSURE TO| EXPOSURE DIAGNOSIS | X I DATE OF DEATH 12 I 14 X t1 HISTOLOGICAL | ESTIMATED | CONFIRMATION 1 EXPOSURE I OCCUPATION | LEVEL | ____________ I__________ I__________ OTHER CAREER HIGHLIGHTS .OTHER COMMENTS Left Hepatecto 1981 High-20 yr (Autoclave Moderate (cleaner I 7 M9S5-1962 | autoclave loperator J1962-1982 X j_________ I High-33 yrejPolyaerieatHoderate- lion Procaae Lou - 5 yra|Han I |Maintenance JWorker I |Health A (Safety Agent X _L J C Contaaaot Letter of S 10 1983 Retired Jan 1979. J C Contaaaot Let tern of S 10 1983 and 25 7 84. 28 I High - |Autoclave Other aectora I 23 yra (Cleaner of St Fcne 01.01.79 (1948-1971 I I Factory 19711978 J C Contaeeot Letter of S 10 1983 1 I 21.03.84 27.12.84 21.03.84 (Hfgh-12 yra|Autoclave |Low - 9 yra|Cleaner C'ENC 006084 09.03.84 tight Jepatect oay 05.OS.8424.09.84 heaorherapy or lungtietaetaala , partial realsslan. 18.84 - liver recurrence. U.84 evolu he Jl Page 9 FRANCE Sheet 5 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH JS.12.32 02.03.25 01. JO,40 iCl CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date; l Jan J986) WPX/ASL - LANCIOCASES.I4 FIRST VC EXPOSURE DATS OF DIAGNOSIS Brlgnoud 07.04.59 26,10.34 Brlgnoud 27.12.65 SEP Hontiucon 01.09.56 05.11.67 AGE AT OlAGHGSlS 45 YEARS OF EXPOSURE TO DIAGNOSES 29 YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OTHER CAREER HIGHLIGHTS I | I t OTHER COMMENTS High Autoclave operator and cleaner (Myocardial (Infarction 11960.Coronary (bypasa 1961. ILetter from (Dr Contaaaot IS.4.66 High High High 1956-70 Low 1970-64 Autoclave operator anc cleaner In other part a 1 Portal of factory since 1946 If1broeia f roe 126,04.74. The llllrteaa was Idlagnoaed aa JpreaLnably I work related Ion 20.04.74. ILetter fro* I Dr Contaaaot Autocleaner Maintenance 4 yeara worker 105.04.66 1 I I Hepatic teat I Hay 64 normal. IHepatlc taat (Hay 66 ahawed labnomallt lea. (Letter froa I Dr Elarrae 116.07.66. ________________ 12 yeara Autoclave worker. 14 yeara In Control Rooi ILetter from (Dr Contaaaot, (At ocheat 12.12.07 1 GENC 006085 _!_____________ I__ XU CEKHANY Sheet 1 XCX CHEMICALS 6 POLYMERS LIVER Angloaarcoaa Caaea - (Review Dace; l Jan 1988) WPX/ASL - LANGIOCASES. l S 1 23 COUNTRY AND reference HO NAHE OR INITIALS DATE OP BIRTH GERMANY 1 1 1l 11 1 4 1s 6 7 8 9 10 n 12 11 14 | COMPANY [ 1 1 J FACTORY 1 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATS OF DEATH HISTOLOGICAL CONFIRMATION i ESTIMATED EXPOSURE LEVEL OCCUPATION | _L ______________1 ___________ _______________ ___________ 11 1 1 1 III t| 11 1 1 1 III II I 1 is OTHER CAREER HIGHLIGHTS 1 1 ( J 1 1 J 1 0I.I0.S6 2S.OI.69 Yea (NIOSH) Polyworker 16 OTHER COMMENTS 16.lO.S7 09.06.S2 00.00.10 I6.04.S7 14.12.71 Yea (N10SH) 10.10.71 Yea (N1USH) Polyworker Pining peatlclde aeroaol cane with VC _L J_ I (Reported under |non polyaarJiaatIon Iworkera in |NJOSH Hat of 111.1,77. |TMa of couree II a atrlccly (correct. (However 1 (wonder |whether thla (sen had high (eapoaure to JVCH in hla Jean filling loperat(on? J______________ 25,J l,74 Yea (NIOSH) 200-500 ppa but high during 1 yr an l'oc leaner Polyworker 6 temporary autocleaner (9S8 waa autocleaner for L yr |Cl I nice! Idetalle In Ipaper by (Gokel et al |VJrchowa Arch |A Path 1976 1172 p 195-201 1 i GENC 00*086 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH (NIOSH gives as Case 06) (NIOSH gives as Case 05} 00,00,32 100.00.26 ICt CHEMICALS & POLYMERS LIVER Angtoaarcoaa Cases - (Review Dale: I Jan 1900) b/PX/ASL - LANGIGCASES.16 6 78 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS 02.04.60 10.12,71 16 ______ _______ _______ J6.J2.62 00.00.75 A3 ______ _______ 15.04,54 I2.JJ.75 49 19.07.54 | 06.04.75 9 10 JJ 12 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF OEATH HISTOLOGICAL CONFIRMATION 11 05 J6.12.74 Yea (NIOSH) ______ 13 12 09.01.75 Yea _______ 21 21 11.11.75 Yee (NIOSH says 12) 25.12.75 11 13 1 JA i 11 Jt ESTIMATED 1 1 EXPOSURE | OCCUPATION J LEVEL t i 11 1J 11 15 OTHER CAREER HIGHLIGHTS | SC Cheat e 1 Isays * |"cheat airy | I laboratories! |In the J 1Techno- l Jlog leal ( |Research | JOepartaent" J KHIOSH says I Jeaalatant | I factory | Jchealst J 1 which aay bef twrong | (translation)! J1 1J J. J 1t |PVC - Menu- l J fact Lire | IShift Leatferl 1t J1 11 |PVC Mai:Li- 1 |facture and J |all work | JlncJ auto- | (cleaning | 112 yrt 1 J(1954-66) J IForeaan Tech| jOev 0 yrs | 1(1967-1975) 1 -L-L_ 1 J J6 1 1 | OTHER i COMMENTS 1 1 1 |Conf1raed 1 IReported under |non-polyaer(laailon Iworkere In INIOSH ltat of HI .3.77 and lJ,79. 1 don*t (chink this la (a correct (claaaif1 cat Lon Iby NIOSH. The (an aay have Jbeen Involved |(n VCH Ipolyaerlaaclon 11n pi lot plant |or In aaln I pi ant. 1 1 1 1 1 J 1 f J J 1 J 1 1 1 i 1 1 1 Polyworker GENC 00*087 Page GERMANY Shee t 3 12 COUNTRY AND REFERENCE NO NAH OR INITIALS DATE OF BIRTH 10 (H10SH glvea aa Case Il) (NIOSH glvea aa Caaa 10) 1C1 CHEMICALS 6 POLYMERS LIVER Angtoearcoaa Cases - (Review Date. 1 Jan I9S6) WPX/ASL - LANCtOCASES,17 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPUSURE TO DIAGNOSIS YEARS OF EXPOSURE OATS OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS 10.10,55 2S.06.77 00.10.77 24.03.78 2S.06.77 07.10.77 High peak* 12 yra polyworker Incl I 72 auto clave cleaning Control root* J yr High peak* 10 yra polyworker Incl I7X auto clave cleaning High _L 3 yra eut clave cleaner 19 yra f11 ter operator PVC Manu facture Autoclave worker for 6 yra 10/ 78 Coni 1 naed Average eapoeure fli 9 yre 150 p| occ 1000 pi Neat 1 yre . 7 & ppo . La yr av 35 pp Average eapoaure 9 yra 150 occ 1000 at yr a 7 5 ppo. lettar ol 21.04.78 GB'JC 00*083 13 GERMANY Sheet* ICl CHEMICALS LIVER Angloaarcoea Cases POLYMERS (Rev Iev Date: Jan 1986) WPX/ASL - LANCIOCASES, l fl 1 J2 1 COUNTRY AND j NAME OJt REFERENCE | INITIALS HO t GERMANY L 1 | S1 i DATE OF | BIRTH J 13 | 1 00.00.14 | 14 | 1 I J 1 1 1 1 1 ( 1 t i I i I 15 1 (NlUSH glvee| Case 11) 16 { 1 1 J l | 1 1 1 J 1 1 1 I 1 1 1 t t 00.00.29 l (00.00.21 | 4 ti 6 ? a COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS _______ ________ 9 i 10 1 1 l 1 12 | n I 14 YEARS OF EXPOSURE TO DIAGNOSIS 11 YEARS OF 1 DATE OF | HISTOLOGICAL I ESTIMATED EXPOSURE | DEATH \ CONFIRMATION \ EXPOSURE | OCCUPATION LEVEL ii 7 aa 4 t 1 00.00.60 06.04,70 61 ,, i L---------- ,------- L9.LO.53 09.10.76 49 I0.01.5S 07.0a.76 (Lelbach uapected ASL at Feb 1975 iaparotoey) 55 16 . 25 _________ 21 1| 1 14 119.05.76 1 Yea t | 1I I| 1| 1| 11 t |Not an 1 | |Angloaarcoaa | | In hib letter ( (0(211281, | (Mr Frledel ( |eald thla was | |a Plattenept-| Ithelkarslnon J | Oe t | |Spelaerohre" | |(a carctnoaa | |of the | loeaophague) 4 |not atrrlbut- | (able to VCH a I |not recagnfaed) |aa an lnduat- j (rial dlaeaae ( i! 25 (21.10.76 1 r i i ( 1 1 1 Yea 11 1 ? |Autoclave i leleaner and i (worker* i (Drier ( loperator. i |Later shift 1 | leader 1 i1 20 J07.06.76 1 Y (ASL and 1 | High (Autoclave i |worker till |Hepatocellular| 11964. |Care loose | Header and t 1 leaater 1| 1* (j 11 1t 11 Ii i i l liEML U j 6 'J 8 v 1 15 OTHER CAREER HICHLICHTS 1 16 I ( COMMENTS I i r i JF W Beat lletter of t30c h Juiw 1980 Jencloalng data (f rem |Hr H P Frledel tof BC Chewle IF U Beat lletter of I'iQU. June 1980 lenclcalng data 1 from III P Frledel of I BC Cheele (withdrawing Ithja caae 4 1 I 1 l 1 i lAngloaarcoaa (09/79. Soee |4 alao caaea (9. 11, 15. 16 |6 17 given In |NRW Report for |l 976 | Angloaarcoaa Iconf Irned, Hull details |of 11 Ineaa 11971 g1 van 1n 1NfiW Med (nap JRep for 1978, 1 Dl f fe rent |decaI U given |Jn "VC | As not' 1 at ed \ DltteJiaii " by JKaratclier |( ll*6l) ji 7 t. iage GERMANY Sheet 5 [Cl CHEMICALS & PULYHERS LIVER Angiosarcoma Cases - (Review Date; 1 Jan 1988) WPX/ASL - LANCiOCASES, 19 COUNTRY ANO reference NO HAME OR INITIALS DATE OF BIRTH GERMANY 17 (NlOSH ftlve* as Case IS) 00.00.37 18 66.60. if IS 00.00.25 00.00.15 21 1 f 1 1 * ! 100.00. 1 1 1 1 1 3 FIRST VC EXPOSURE SATE OP DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP HISTOLOGICAL DEATH CONFIRMATION ESTIMATED EXPOSURE LEVEL OTHER CAREER HIGHLIGHTS I | I OTHER COMMENTS 01.11.61 14.06.78 26.08.78 High Autoclave worker 00.00, 4s.iT.tt IS.10.54 00.06.79 ST ~S*" "ir 2S.li.>9 22.02.60 Yea He teata*log High Autoclave Worker Autoclave Worker t | Ang 1 ojiircoar |conf 1 need, |Annual report I of the North Ilh1ne lUestphalta (Medlcal |Inspectorate |for 1976 Ipages 147-177 Iglves full (decalla. Vinyl Jchlorlde IdLaeaae Jdlagnosed 102-02-71. I Oesophageal Jvarlcee. I RadloIoglcally |confirmed aero loateolyela. |Dr Beache lletter of 113-04-82 to I Dr U G P Ada 14.02.61 00.04.60 19 Yes Kaeaanglo Endothelloaa of liver with Netaataaee High Autoclave Worker |Dr Beache lletter of H3-04-82 to |Dr W G P Adaas I 4 1 4 0U01 62 1 00.09.79 t 66 18 1 13 |19.06 80 | Yes | High (Autoclave | (Dr Beache *1 11 (pronounced | |c1InlraJ | \ 1 1 IHaeaanglo j 1 1 |EndothelIona | |Worker and | |wurked In | lletter of 113-04-62 to 1 111ve r | 1 1 1 |of liver with | fd rylng shop | | Dr W G F Adas* 1 isyvkCunii) { 1 JMetastabeii | 1 1 1 11 1f 28.08.B0 1 1 11 06,12.81 !1 k l High Autoclav Chargehand, |Dr Beeche le I ast as I ng ASK Worker subsequently Foreman lletter uf _____ i2 tu Adana fiFl-l! 06090 Lit.AHA NY Sheet 6 (Cl CHEMICALS & POLYMERS LIVER Angiosarcoma Cases ( Rev Date: l Jan J988) UPX/ASL - LANGIGCASES,20 COUNTRY AND REFERENCE NO NAME OR EKET1ALS DATE OF BIRTH GERMANY 21 00.00.27 26 28 1 1 I 1 i t \ i i i I i l 12 00.00.2ft 00.00.23 06.05~.22 00.00.28 til n.ji i l\ i1 t1 l1 tt l1 i1 i1 i iI tI J_. 1 00.00.22 00,00.17 00.00.23 00.00.10 V1 l I I 1 I t i t I i I J J ... FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER H1CHUCHTS OTHER COMMENTS 1955 29.09.Si High Chemistry ('300 ppo) Worker I I Primary hepatocellar Icarcinoaa; {proliferation of the lalnusiodal cells with Islnusoldal ectasia, IFriedel Utter 23.12.ftb. 1969 I960 28.69.81 1953 14.06.76 2ft.05.S3 11 22 "17" 22.11.82 High Autoclave ('300 ppm) Cleaner High High Polyclave Worker and Autoclave Cleaner Polyworker 1955 lA.dl.83 tr IT 02.03.64 High _L Autoclave Cleaner till 1972 1 Ol.lO 60 i 11.08.85 i1 1 i1 it t1 iI i1 i1 i1 tJ ii .. ! 15.02.83 1 1 f 1 1 1 J 1 i 1 1 1 61 25 ____ 1 25 125 on.ei j Yea | High {Process | 1 i1 |worker 1947-1 1 11 |ft4- (01.10.601 t 1i 1-31.03.84 | 1 11 1 111 ( 111 1 i11 t 111 1 111 1 J11 1 111 1PVC product-| lion, | lagltetor t {area). 1 1 1 | 1 1 1 ii ! \ .. 1 . l !1 High 07.0 I. flO High Poly-.rork.er Shift leader IProf Eder (Huntch) Jletter 22.Oft.S3. tFrledel letter 19.04.85. I Prof Seimalr (Munich) lletter 22.08.83. IPriedel letter 19.04.85 (Oironlc hepatitis, (angiomatosis, sinusoidal lecteala. Frledel letter 123.12.86. |Lelbech. IFriedel letter 119.04.85 fAnnual VCH screening 124.04.85; no complaint. Jno abnormality detected. | 1 970 two-thl rds Igaatrectomy for ulcers. 11971 Coronary thrombosis 11981 Femoral |lap 1 ant a 11 on 11964 Pulmonary eahullaa (and pleuropneumonia. |Landers letters 18.09.85 land 04.02,87. 1________________________________ 1 Ha eaa ng 1os arkooa. IFriedel letter 21,12.86. J__________________ ____ | Haenangf oaarkoiaa. IFriedel Utter 23,12.06. 1955 00.64.ns 23 lAllvu Autoclave - leaner Polymarker I ave |Haemang1oasrkoaa, |Friede1 Lett er 21,12.86. _L I Hnuaa ng t osa rk cuius. IFriedel Letter 23.12.86. GEtlC 00 6 L?1 _L_ Page ITALY Sheet I 16 ICI CHEMICALS 6 POLYMERS LIVER Angiosarcoma Cases - (Review Date; 1 Jan 1986) WPX/ASL - LANGIOCASES,2J 1J l |2 1 J!L 1( COUNTRY AND | NAME OR j REFERENCE | INITIALS | NO 1 1 ITALY J1L l J 1I 3| 4| 1 DATE OF 1 BIRTH | COMPANY 1 1 1 ( 1 _______________1 l1 5 FACTORY 01 (On N10SH suppleraentary Mac) 02 03 04 1LC 1 1 1 1 1 1 J1L 1 (SE 1 1 1 |VC J ( 1 i J!L 1 |FB 1 i 1 1 1 1 1 1 ( l 115.06,14 | PANSAC (Mira (1 (Venice 11 1 11 1 11 1 11 1 1I 1 t. i1 1 1 Hont*dlaon|Porto 1( 1 Marsh are \1 11 1 14.01,20 j Solvay ( 1 IFerrara 11 1 l1 1 11 1 ii 1 11 |20.07.17 j ANIC ! k |Ravenna 11 t| 1 1 1J 1 11 1 11 i (1 i t( t 11 1 11 1 11 1 11 6(7| 6 11 11 FIRST VC | DATE OF | AGE AT EXPOSURE | DIAGNOSIS I DIAGNOSIS 1( 1L_ 1 1 1I 00.00.65 ( 19.04.71 | 36 11 (1 11 1J 11 11 1L_ 1( 00.00.57 ( 11.12.72 | 41 11 1 1 00.01.53 | (0.07.75 1 1 | 55 11 11 11 1! 11 00.04.59 | 00.01.61 I 11 11 11 11 11 11 (1 11 1\ 11 43 1 11 ( 11 1 11 1 1 1 (1 11 11 J1L 1 05 1 I I |C Daneeln (19.03.37 1 PANSAC 1 (HIre !! 1t 00.00.67 ( 07.03.83 l 46 1 11 1 t1 9 11 i 1| (Venice 1 1 1 11 11 11 11 J1L ! 1! *- M.i It nit 1 Ned <il LavuCk) 6 5 ji445, IS 74. Fur tlief details In letler I run Dr Mnnt ubsii t e Killnjil and Kondlnel 1 a 1 n Art a Oncologic H Vnh 1 1980 pugci* 15 - 49 i1 11 9 1 io t U 1 12 1 11 t 14 ( it 1i i1 tJ YEARS OF | YEARS OF | DATE OF ( HISTOLOGICAL I ESTIMATED 1 J EXPOSURE TO | EXPOSURE J DEATH I CONFIRMATION | EXPOSURE ( OCCUPATION ( DIAGNOSIS 1 1 1 LEVEL l | 15 OTHER CAREER HIGHLIGHTS 1 1 1 1 | 16 OTHER COMMENTS _J 1 11 11 i 06 1 03 (16.04.71 ( 7 Yea 1( 11 1( 11 11 11 1 _____1 1( 15 | 06 (27.(2.72 ( Yee J (PVC bag (eat ruder ( 1 1 l t 1 1 | 1 1 1 ( j 1 i IPolyworker | (Primary tumour |may have been | per Icardlia. |Hoc hoaoIgeneoua with |other caaee. |* ** 1a 1 (i -J 1 11 22 1 21 |10,07.75 f 11 11 (1 1\ Yes 1 High ii lAutocleaner | IS jr. (1953-1 1-6 11 Autoclave loperator | 112 yra (1961- ( I ( 1972-5 did a variety of| Job* | Including | PVC pecking | aa a* _i i 1( 21 1 21 |30.03.81 ( 11 11 11 JJ (1 (t (( (1 11 11 Yea jm..... .. i 1 i ( (2 yra - (1 yr - |Never cleaned | Very Kfgh I Monomer | autoclaves. | | 5 yra - | Medlua loperator 1 I 20 yra - (See paper by J ** ICHUPP1NO .t )Non-smoker. |el Hed Lavoro 1 Consumed | 4 yra | Low (Autoclave |Vol 6 (1982) loperator 4 |pp 555-563 (other dutleal 11lttle lalcohol. IAOL. No (In suepene- | (ion polymer-J 1 i (laatlon. | 1 1( 11 11 |Area Foreman) | to aaee Oept| (since 1975. ( ] 1 _! i 16 l t 1 1 1 1 1 1 6 (06.04.81 | 1 1 1 1 Yee |Hedlu-? |High ii 1( (Beg estruderj ((967-1975 ( (CofMerclal | (Oept 1976- ( | J9H] | t1 1 IS Paglla1 Lungs teles of 12 AuK 1993 f ( > nn April Iut I9H2. 6EHC fj06U`7- 1 ITALY Sheet 2 [Cl CHEMICALS POLYMERS LIVER Angloearcojaa Cases - (Review Date: I Jan 1988) UPX/ASL - LANGIOCASES,22 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH FIRST VC EXPOSURE YEARS OF DATE OF ACE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EX POSURE OtACNOSIS DATE OF DEATH HISTOLOGICAL ESTIHATED CONFIRMATION EXPOSURE LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS ITALY 06 1 CZ (21*06 36 |Hontedlaon |Porto |0) 10*60 J06 12*as i 49 | 25 | 25 | 3.02*86 i Yes |Hi*h f PVC J 11 1 (Marchera \ i 1 l1 1 |1960-71 leanufacturet II 1 | Venice 1 1 i 1 i t 1 (Medlua | 11 years aa| JJ 1 1 1 t i 1 i\ I 1 1971-74 lAutoclave | t1 1 111 1 l1 1 1 Low Ideaner | 11 1 t 1 l I I I1 1 11975-85 \1960-71, | 1i 1 1 1 ( i \ I1 1 1 |14 yeara ln| II 1 l 1 I i I l1 1 1 |ControI | 11 1 1 1 1 i 1 ii 1 1 IRooa | JI i 1 I 1 I i 1 i1 i ij I I197J-85 | | Letter* from Dr Chioislnl, Venice J 22.09.87 and n.Ol.BS J 1 l J I i t 1 GENl 006093 'aK** JAPAN J0 ICI CHEMICALS 4 POLYHEHS LIVER hi^loesrcou Cases - (Review Date: I Jan 1988) W-PK/ASL - LANC10CASES.23 l 12 131 COUNTRY AND t NAME OR | DATE OF REFERENCE ( INITIALS 1 R1RTH | 4 COMPANY 1 |5 1 1 1 | FACTORY NO 1 JAPAN 1 1 1 1 01 |?oaoj1 |01.08*22 )Mitsui |Nagoya |Morl IToatau 1 1 J 1 1 1 1 1 1 I 02 |SC 1 11 102.08.39 (Kartegafuchl|Osaka 6 FIRST VC EXPOSURE 00.04.53 00.11.58 7 DATE OF DIAGNOSIS a 24.10.75 10.08.76 8 AGE AT DIAGNOSIS * 51 IT 9 YEARS OF EXPOSURE TO DIAGNOSIS * 22 17 1 10 l 1 11 1 1 12 j 13 1 14 i J 5 1 16 1 J JL 1 i1 t YEARS OF 1 DATE OF HISTOLOGICAL | ESTINATE0 i i EXPOSURE 1 DEATH CONFIRMATION | EXPOSURE | OCCUPATION | OTHER CAREER J 1 | OTHER | . COMMENTS t | LEVEL 1 * HIGHLIGHTS i 1 J JL J 1 11 1 1 1 11 1 J i n 124.10.75 1 1 1 1 l l t 1 1 1 11 J Yes |PVC Assoc 113 yrs auto-| Isays not |clave 1 iknown. 1* Japan Icleaner 1 1964 - | | iTlaea lasslgned to | (indicated (different 1 Jon 25.10.75Jwork alnce | (exposures |had HI | (often at Ihealtb | (3000 ppo up| | |co 1974 1 1 i |Japan Tines 125. 10.75 4 |Japanese PVC |Assoc letters |of 31.03.78 4 (30.11.87 1 1 1 1 J 1 i 13 110.08.76 Yes J JL_ 11 1 |Hot known |In poiyaer- | 1 J (Japanese PVC laation nock Aasoclation Inc lading letters of autoclave 31.03.78 4 cleaning 30.11.67 1 03 | YS 1 1 1 1 1 11 (01.09 30 IKlceul 1 IToatau 11 11 11 11 1 |Nagoya 1 1 1 J j 1 | 00.07.65 1 1 1 1 1 1 26.06.85 1 1 1 1 1 _______________ I___ 54 ___ L_ 20 11 5 114 09.85 | Yes 1 11 1 11 1 11 1 11 1 |1 11 1 High |5 years 1 1 l ILetter froa 1 |Autoclave | l Icleaner | (Dr Nakaaura, (Japanese PVC ii 1 |Aasoclation 1i 1 |30.Li.87 1 -JL__________________ i___________________ * In hla otter of let Apr! 1982, Dr Honteaano of (ARC says Japanese Ministry of Labour give Date of diagnosis Age of diagnosis Years of exposure 21-08-74 52 22 GENC 0060?4 Page J9 NORWAY [Cl CHtHJ CALS A POLYMERS LIVER Angioaarcoaa Cases - (Review Dace: Jan I 968) WPi/ASL - LANCIOCASES.24 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FIRST VC EXPOSURE DATE OP DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOCICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS 23.12.IS Norsk Hydro Heroy* 00.03.SO OA.Ol.72 High Forenan & Autoclave aupe rvlsor Conf1raed by Dr ThfUEvanaen of NH. At aPHE Htg of 9 June 197D Mr P Rangnea atated that AH had been a eaber of a at art-up ceaa. VCM A PVC were Bade In *aae tmlldtng. The VCH waa Bade froa acetylene GENC 0U6H9- Page SWEDEN ICl CHEMICALS 6 pOLYHtKS LIVER Angiosarcoma Cases - (Review Date; Jan 1988) WPX/ASL - LAND IOCASS,2 5 1 COUNTRY AND J REFERENCE | NO ( SWEDEN l 1 ) \1 NAME OR J DATE OP \ INITIALS | BIRTH J 11 1L ii ii COMPANY 1I 1 1 FIRST VC | DATE OF | AGE AT FACTORY | EXPOSURE | DIAGNOSIS | DIAGNOSIS 11 1 LL I1 1 I1 1 YEARS OP EXPOSURE TO DIAGNOSIS 01 | NU i 123.06.27 ( Kernsnord (Sundavall | 14.08.51 1 20.10.70 | 1L _JL L L 27.II.IJ QO.OI.45 43 _L 19 I years or | 0ATE or EXPOSURE | DEATH 1 J__________1 HISTOLOGICAL CONFIRMATION 11 ESTIMATED 1 1 EXPOSURE j OCCUPATION | LEVEL 1 1 11 OTHER CAREER HIGHLIGHTS ( ( | OTHER C0HMENTS 11 11 18 (20.10.70 Yes | Polyworker | _______J__________J ___________________ 1 J________________ L I1 27 (16.00.72 High | VCM | ( (production | II Mr S^oelln'i letter of 26 March 1970 confirms BL waa a aonoaer worker who was heavily exposed, probably even ore ao than a noraal reactor cleaner 10.06.10 16.Ik.14 00.05*47 J8.03.76 00.00.46 12.05.77 21 (19.03.76 tt 31 112.05.77 ( 122.11.80 1 IJ GB^ 006096 High High |Polyworker ( J_____________ L 11946-1958 J | polymer- ( (leaden | |worker (12 | lyre) 6 1950-| 11977 foreman! ((19 yre) J (I Ii 1* (I High 6 Years Low ID Years _L J I*964-1970 Icent Mfnge (operator 11970-I960 Idrler |operat or ( j--------------------- In first 12 yra of caploynent had been heavlly exposed. in 1974, liver a bno rai11C y and necroala dlagnoaed. lata confirmed Ln Dr 0 Byren letter 10.8.77 to ceric letter of 2nd Nov 1981 F roai Ir David Byre a letter of 1st April 1982. I>r Honteaano of 1AHC says In Sweden's National Board of' llth gives 20-02-70 aa date of diagnosis for Case IIj and 15--US-- ?2 for Case 02. Page 21 UK Sheet! IC1 CHEMICALS A POLYMERS LIVER Angioaarcoaa Case# - (Review Dace: J Jen 1988) UPX/ASL - LANG I OCAS ES ,26 1 1 12 J3 ! i1 COUNTRY AND J NAME OR 1 DATE OP REFERENCE | INITIALS | BIRTH HO 1 -J 1 UK I 01 |WJ 03 IftJW 04 t JSR f20*04.01 l 1 1 1 1 1 1 1 1 1 J 1 1 (02.06.07 t 1 i 1 123.06.20 1 1 J ( I 1 1 J \ \ 1 1 1 1 ( 1 1 1 1 1 I 1 4 15 6 7 81 9 COMPANY i FACTORY J PIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT | YEARS OP DIAGNOSIS | EXPOSURE TO DIAGNOSIS ICI |HiHhouse 04.04.44 03.J2.72 71 1 28 (For 4 Collier paper says 23, 12.72) jl j BP | Berry 00.02.66 00.12.74 j' ICI (Hlllhouae 26.04.54 00.06.79 37 | 09 t 59 1 25 __________ L 10 J 1 12 YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION 22 03.12.72 (Pox 6 ColLler paper aaya 23.12.72) Yes 3.5 24.12.74 Yea 18 12.10.79 Yea 13 1 14 4 t5 ( 1 ESTIMATED I EXPOSURE | OCCUPATION ( LEVEL l OTHER CAREER HIGHLIGHTS i 1 1 500 ppa 1 |1944-7 VCH 1 |1947-8 Drler| |1948-61 |Autoclave (operator j I96J-66 (Drier ( 1 1 \ 1 1 J 1 J * High JAucoclave Icleaner 1 1 1 1 1 tI Medinahigh 154-5 | Bagging JP1ant |55-6 |Drier Plant 156-58 1 1 Pre-war fLah 1 packer (1939-45 anay Ivehlcle (Maintenance 11945-54 |Autoclave |worker |58-6) )Chergehand (Drier | Plane |6l-72 | Fo renan (C 2/3 Plant Jfleh packer 1 1 1 1 1 1 1 1 1 1 1 1 1 1 16 | OTHER | COMMENTS (Lee and Harry |Lancet 129-06074 Ipagea (316-8 |Dubloui (fabrication (caae (Eapoaure (Halted to (2.66 - 9,69 j G ENC 00609 Page UK Sheet 2 ) I2 COUNTRY AND REFERENCE NO UK 05 NAKE OR INITIALS DATE OP BIRTH 30.03.14 1931 nr RGB l6.CU.i4 os 08.05. i-* BP Barry Barry Barry Barry ] C t CliEH I CALS 6 POLYMERS LIVER Angloaarcoiaa Canes - (Review Date; 1 Jan tfPX/ASL - LANG IOCASKS,27 PIRST VC EXPOSURE DATE OF DIAGNOSIS OS.01.51 OO.LO.79 "oOOcT Twr bo.oo.eo it.ot.ib 2J.U.81 AGE AT DIAGNOSIS "wr TT YEARS OF EXPOSURE TO DIAGNOSIS 2D IB YEARS OF EXPOSURE DATE OP DEATH S72 11.66.80 X 24 25.J2.S1 j 13 15 HISTOLOGICAL CONFIRKATION ESTIMATED \ EXPOSURE | OCCUPATION LEVEL __________ i 11951-52 |Polycleaner 11952-55 | Latex 11955-60 J Potyfloor mo-64 (Poly IChargahand 11964-70 | Charging (operator |1970-72 |Drier loperator J_ IT rr (Poly Floor lOperator 15 yra (Greaser on I Poly Floor I Polycleaner 1J 963-5 (Recovery 11965-1971 I J. 1950-1958 iiiw-si 500 ppa I AuC oclave 1968-1974 loperator 200 ppa II 951-195? (Chargeaan lautoclave |building 11957-1974 | Shift laupervlaor lautoclave Ibulldlng - |Never |cleaned lautoclavea Ibiii lauperv lanr1a IJob entalled {entering | a u[oclaven |Co (napect OTHER CAREER HIGHLIGHTS 193S-194S _L Motor Mechanic J946-1950 Operator on Acetylene Production Plant OTHER COMMENTS GNC 006Q?s Page 23 UK Sheet 3 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE cSF" BIRTH 07.05.2S 04.04.47 08.05.26 24.01.37 Barry Barry 1CI CHEMICALS 4 POLYMERS LIVER Anglosarcoaa Casea - (Review Date: l Jan 1966) WPJtfASL - LANC10CASXii,2 8 FIRST vd EXPOSURE 15.02.50 DATE OF DIAGNOSIS 02.03*S3 AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 33 YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL COMF1 RKATION 24.02.S3 TT IS ESTIMATED EXPOSURE LEVEL dim OCCUPATION Polyworker OTHER I OTHER CAREER | COMMENTS HiCHLICHTS :_______________ I 2 year* on Acrylonitrlle Resin plant. Afeo prior to 1950. 4 years RAF Maintenance. 3 years Motor car palntahop. 2 years In Graving Dock. 27.04.66 High - U Polycleaner nontha (500 1966-67. ppo}. Low- Spray-drier JB Months (50 Pfa). .bagger 1967- 68 Hedtua - Blow-down 21 nontha stripper (200 pin) opera tor 1968-70. Heavy goods | Intonation vehicle driverfglven In until final | letter ilines. f 1B. 06.84 f rn I Dr D M J i Ui ill ana I 02.06.B5 High 1965 -69 Hed 69-79 Low 79-82 PolycLeaner J965-68. Service operator 66-69. Foly Operator 69-79. Leading Hand 79-62. Low 1957-69 Spare man High 59-74 bagging Low 74-86 floor 1957-59. Antoclave Ope ra(or J 959-86 1 ILetter of I04.06.B5 (Dr Paul Saleh land letter of 104.06.65 JDr 0 H 0 Evane |Oesophageal lhaeoorrhege Idue to loeeophageel Ivaricea due to |Angloaarcoaa |of liver J____________ ILetter 126.06.85 jDr Y I Lee I I genc 0 Page 24 UK Sheet 4 [Cl CHEMICALS 4 POLYHERS LIVER Angtoearcooa Caaea - (Review Date : January J9B8) WPX/ASL2 - LAHCIOCASES.8 11 1 12 \ 1 1 4 COUNTRY AMD REFERENCE 11 ii (NAME OR ( |INITIALS! DATE OF BIRTH 1 j COMPANY MO 1 1 i___ 1 L l i I1 UK | MJ 102.01,48 |BP 11 1 1 i 1 J t 1t 11 1t 11 | 5 i6 | 7 1 B 19 lI 1 10 nLI 1 12 1 1 14 1i 11 l tYEARS OF ( i i 11 IrtlSTO- 1 1 |FIRST VC \ DATE OF \ACE AT | EXPOSURE | YEARS 0F| DATE OF |LOGICAL 1 ESTlMATEDl | FACTORY leXFOSURg |DIACNOSISlOIACNOS[S|TO (EX POSHRE| DEATH |CONFIRH-| EXPOSURE | OCCUPATION i1 | DIACNOSI S| | IATION | LEVEL \ 1j 11 1 11 JL 11 11 11 i ia| Barry I 1968 | Jan 86 1 37 13 1 02 0b.H6 1 Yea | High I Polycleaner 11 11 ll 11 11 11 1i 1J iI 11 t| i| Low High 11968-69 |Central 1 Depot 11969-70 IPolyfloor 11970-1971 1 1 is 1 16 1 1 1 OTHER f CAREER | | H1CHLICHTS OTHER COMMENTS 1 1 1 |Moved (o lAcryLonlt rile IPLant until lleft BP 1983. |Regained well, work (actively, until Jan L98o iManager of | 1C A SS Ltd at jCardlff Airport 11 14 ICS 1 IS 06.42 |BP 11 11 ll 11 11 t1 11 1l 1,, . 1 ______ 1 | Barry 1 1 l 1 1 1 1 1 1 11 107 07.66 127 08.87 | 45 111 1 11 <1 1 11 111 t11 1 i1 111 -1 1 L- 1 21 1 11 1 J 1 1 1 1 1 l 1 1l | Alive 1 1i 1t il il il ii il ii * _J li l Yea 110 sonthalPolycleener | 1 High 11966-67 | 1L0 years 1 Poly floor \ Iconatant |worker at tl*ea| ]Hedlim Ibetween | (but on 11968-1982 | (Inter- 1 tnlttent 1 1 1 Ub 1 1 _J JL-. _ l ILettere from Dr DMD Evans, |Pathologist, Penarth, Wales land Dr DHJ HI 1 liana, flp, Barry t 1 1 1 1 1 L__________ GENC 006100 i i fa*e USA Sheet 1 25 [Cl CHEMICALS 6 POLYMERS LIVR Angloaarcocaa Case# - (Review Date: l Jen 198B) EJX ayatea of daces DAY - MONTH - YEAS UPX/ASL - LANC[OCASES,29 COUNTRY AND REFERENCE NO HAKE OR INITIALS DATE OF BIRTH Earl Parka 17*10.21 Edward 25.05.15 Dinwiddle 25.01.1 2 Ray Auetln Jonea? 21.11.28 Charles T Seart J FACTORY I 1 J |LoulaI vlUe \ I FIRST VC EXPOSURE DATE OF DIAGNOSIS 03.01.71 ACC AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH 01.03.71 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION Pot Cleaner (Block Jua J974) p 53 OTHER I | OTHER CAREER | COMMENTS HIGHLIGHTS | J___________ I Hlatory Riven {Roiling Stone In Annate NY |Art ACAD SCIENCES {Ref 1 NY Acad Vol 129 ( 1979) |of Sc Syap page 190 In 11974 Paper by {Aleo Block B R Cot tine of)Jaae J.7.74 OSHA |p 51 |Louie' I vlUe 15.11.55 00.05.70 |Loutsf villa | Lou laI villa 19.12.71 27.09.71 (NIOSH aaye 23.09.71) 19.12.71 07.01.63 Pot Cleaner (Cf Block) Pot Cleaner (Cf Block) Louleville Courier Journal 02-09-BO Pot Cleaner (Cf Block) 1 I Ref j fAlao Block MAMA 1.7.74 Ip 53 J_________________ IRef J I Also Block i J_______________ IRef I lAleo Block ILoule\ villa J_______ I LouieI villa I 1 l 19.06*44 09.04.64 00.02.74 | S Chari e | stem 00.00.68 09.04.64 Pot Cleaner (Cf Block) US A1r Force Pot Cleaner (Cf Block) IRef I JAleo Block IRef 1 + |Loulevllie {Tinea 21.7.75 | Ret ired Aprl l 11974 lAleo Block _L t iloud year | N l hr a ra 29.08.61 SENC 006101 Hajie 26 USA Sheet 2 LC[ CHEMICALS A POLYMERS LIVER Angiosarcoma Casea - (Review Date: 1 Jan 1966) UK ayatea of tUtea DAY - MONTH * YEAR WI>X/ASL_2 - LANClOCASeS *f ` 12 l3 J________ J_____________ j COUNTRY AND | NAME OR | DATE OF REFERENCE | INITIALS | BIRTH J_ _ _ _NO 1 J________ USA 1 J 4 |3 COMPANY | FACTORY 6 76 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIACNOSJS __________ 9 10 11 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE _________ DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 1 14 1 J 5 1 1 | OCCUPATION 1 | OTHER CAREER HIGHLIGHTS 1 ( * 1 1 1 J6 OTHER COMMENTS 09 | Raymond (08.11.3] RFC IGettle- 1 | Finger? 1 11 11 11 1J 11 1J J_________J________ 1 |Louie| vine 26.03.43 OJ.03.74 43 Jin | 16.06.13 Goodyear (Niagara 12.06.31 00.03.66 _________J________ 1 _________ 1 55 i I27.0i.09 Goodyear |Niagara 14. 10.46 00.03.70 61 j_________J________ !_________ l 29 24 11.03.75 17 L7 (0.05.68 ____________ _________ 23 23 L6.03.70 ____________ _________ Yes 2000 ppa Yea Yea __________ i (Ref 1 has |wrong flgurea |re first Jexpoaure. |Loulevllle (Tinea (29.10.74, t J 2.3.75. 110.3.76 1 i JRef j 1 J IRef ( J 12 IFrencIa A 117.11.16 Ft reatone |Pottetovn J3.07.49 02.03.69 | Bachman 1 J 11 11 11 11 11 ! j_____________ 1 n IRIchard IOI.12.2J UCC (Edward ( fCleodenln j _____________ _______ |S Char le- M. 12.42 | aton 00.03.74 j_____________ j_____________ 1 14 1 1 1l 1t J1 i1 11 11 1j 50 20 L9 02.05.69 ____________ ______________ 52 32 26 07.04.74 ____________ Yea Yea I II II I I I 1^1 II II I I I * III III High 10 yra 10 yra aa (Utility k reactor op. |Service op. {not cleaner J Bagger - separate JDryer op. crew cleaned)Stripping op. autoclaves) |3 yra prior leervlce In IRef 1 letter |of 26 April 11976 iroa 1 Russell A Park I to J T Seawel 1 |of MCA | (tyre plant ( i1 2000 pfa J |CharJ eeton 1 Dally Mall 121.7.75 i1 II SENC 006102 I ' |Never dlag|noaed as ang1 Icearenas of |llver. Inform1st Jon gIven In lletter 22 May 11984 from |J A Salg. 1 I |Account ant; |ASI. - No evi- VCM Page 27 USA Sheet 3 [Cl CHEMICALS A POLYMERS LIVER Angiosarcoma Cases - (Review Date: J Jan 1988) UK System of dates DAY - MONTH - YEAR WPX/ASW - LANG IOCASES , 2 1 l |2 1 4 IJ COUNTRY AND | NAME OR REFERENCE | INITIALS NO DATE OP RUTH J1 1 1 COMPANY | FACTORY 1 _____________ ______________J! 1 USA 1 67 a FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS _______________ 16 |James 04.1*.27 BFG (Howard |LouisIvllle 08.OS.SO 00.00.69 1 J 1 1 1 L 7 |Peerenbooa 06.OS.31 RFC 1 |Louts- Ivllle 23.06.55 JJ. 10,74 1 1 1 1 18 (Chari le 22.04.2S BFG |Arthur j 1 JAvon Lake 1 1 1 l 1 1 15.09.54 00.00.75 _____________ ______________ JL l 19 iVirgil 00.00.IS ucc |S Charie- 00.00.43 *9.06.35 | Christian | aton J 1 1 1 JL 1 20 Ji.Ofl.17 Goodyear I Niagara 00.00.55 10.01,76 1 21 |Chester 02.09.09 UCC f lilnkl e JL i |S Cliarle- 00. 1 2.44 | ulna Early 77 1 1 1 JL 41 41 46 60 5fl 67 9 YEARS OF EXPOSURE TO DIAGNOSIS 19 19 2L 32 21 30 10 1 11 1 YEARS OF | DATE OF EXPOSURE | DEATH 1 f 04 127.01.69 1 1 1 j 19 1I6.i0.fl0 1 1 13 102.11.75 * l j 12 106.04.76 1J 1I J! I Ifl 130.01.76 j 22 102.01.77 | 1 1 11 12 | 11 | 14 11 11 H1ST0L0C [CAL | ESTIMATED | CONFIRMATION | EXPOSURE | OCCUPATION | LEVEL | 1 1 1 1 Yea 1 | 1 L 1 1 1 | 1951-4 VCH |polymer- |lation 11 11 11 11 Yes on H,10.74 but no poat-aortea 16.LO.flO ( 1 1 1 I 1 1 1 1 t | 1 1I ii 1I Yes 113 y re | Navy \autocleane r | |8 yra on J lEetol ITyre Store Iplastlciserf Jfc Carboset f (operation ( 15 OTHER CAREER HIGHLIGHTS 1 1 1 1 J | 1 1 16 OTHER COMMENTS From L954 1 |Table 4 in onward a in |Wagoner Amy and other| TeBt iaony to service. 46-50 Amy |US Senate |Conf traed 1n |H N Johnson llir 07.08.76 t |Dr H N Johnson (letter of |24,2.BI conIftrmed death |6 years after (diagnosis | Coni 1 rued in |M N Johnson |Ur 07.08.76 |A L so Rol1 log (Stone sag. 115.01.76 Yes Yea Yes j_______________ i_________________ (2000 ppa 1 1 1 1 1 1 1 1 it 1t 1 1 1 \ l I 1 1 1 1 W[ 1J1 aaa port |Sun Caret te 121 June 1975 (Charleston I Dal 1y hall 121.7.75 ( INIGSH Letter |of 25.10.79 J 28 yra with fOCC at SC |Ret1 red (News u`lL-in |21.2.77 i yENE 00610.3 1 USA Sheet 4 ICl CHEMICALS & EOLYHtHS LIVER Angloaarcoaa Cased - (Review Date: Jan 1938) UK syaten of dates DAY - MONTH - YEAR 2WPX/ASL - LANCIOCAS&S,3 COUNTRY AMD REFERENCE NO USA NAME OR INITIALS OATS OR BIRTH 02.10.23 FIRST VC EXPOSURE DATE OP DIAGNOSIS LoulavlUe 11.07.47 00.01.76 21 00.00.23 Creat Fitchburg 08.04.58 06.04.73 Aaerlcan Haae. CheaJcal x 24 Charles i.oi.iJ Coopany UCC S Qiarle- "TOT Edward a ton Hoore (25) 11 f runt rej{ rned In H Kaalnakl let I AGE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS 29 15 YEARS OP EXPOSURE DATE OP DEATH 04.12.76 06.04.>3 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL _L I I OCCUPATION J 15 OTHER CAREER I HICHLtCHTS i. 1 J OTHER |. COMMENTS \ I |Loulavllie iTlaee 26.1.76 |aald he waa ) the lOth as ivice la ac |Be J J a Lane of |whoa 3 had Idled by 126.1.76 {In hie letter (of 16.09.81 |Dr H N Johnson Iconflraa thla 11a the Iceae deacrlbed I by Dannaher iTaaburro 4 Yaa I in Peb J980 |Aa J Medicine IVol 70 p280 I To- 18 r of 5 No vein be 24T (NIOSH aaye 26) TTMTTf Cholaogloaarcooa <R Raalnahi 26/2/79) _L fediiai to 1941-65 non- l9i7-39 ... high for solvent loff and on 24 yra vinyl reain 11afaourer unit and 11^39-41 aay diape rafon {have been vinyl reelna lexpoaed ae unit flrat ireactor aa fitter Jcleaner helper, then 11943 becaae IN H Wheeler lletter of 118.8.77 to |J Stafford Igivee detalia IRoae Kaalnakl Matter of 126/2/79 |R Kaalnakl ehlft lahift fitter 1(5 Nov 1980) util Icy aan l1946 becaae lauggeats that lahift utility |NIOSH will |aan |retaln on 126.04.65 register since leaployaent waa Ithla neoplaea 11 etainated |aay he associ- \ j_ated with ASL. N Wheeler lletter of 6ENC 00610^ 120/2/79 and iRoaeKajsl nakl |lei^^^>f Page 29 USA Sheets 1CI CHEMICALS & POLYMERS LIVER Angiosarcoma Catsee - (Jtevleu Date: l Jan 1988) UK. system of dates DAY - MONTH - YEAS WP X / A SL 2 - LANCIOCASES.4 11 l 12(3 .1 ... J.. COUNTRY AND | HAHE OR | DATE Of REFERENCE | INITIALS | BIRTH NO USA ji 1J 11 4 1 3| 6 -Jl ] l FIRST VC COMPANY J FACTORY J EXPOSURE _JL 11 7 DATE OF DIAGNOSIS 26 |John Berry|07.07.23 RFC (Louis- | 03.10.47 00.00.77 11 Ivllia | <up to 2 it 1I year* 11 11 11 11 after death) 11 IJ 11 i1 11 1i 11 11 11 J1 1l 1l 11 1l 1t 11 1f 1l 27 |J L t11.05.16 UCC ii |S Chsrle-| 01.07.41 30.ll.t8 |For rest | | aton | 11 J1 ii 11 ii 11 i i 26 1 1 i i Ml.0i.l7 1 UCC 11 J1 -1|,S --1 Chsrte-| | aton i 00.0S.44 03.tl.7fi 1 29 1 1 1 112.10.07 t UCC t . ... i |S Charle-| 00.OS.42 | eton | 00.03.80 1J 30 |WVN 122.07.22 Tenneco 1 |Flemlngton ll.Q6.64 30.12.80 11 Chemicals 1 1 11 ii 1t 11 i i i f 31 f i i j i 109.11.23 UCC 11 11 I1 ii J S harle-| 12.03.46 01.OS.81 ACE AT DIAGNOSIS 52 (death) 62 61 72 58 57 9 1 JO 1 H .1 i YEARS OF 1 YEARS OF I DATE OF EXPOSURE TO 1 EXPOSURE | DEATH DIAGNOSIS 28 (death) 1 16 |J J.02.75 12 1 n 14 J \ HISTOLOGICAL | ESTIMATED 1 CONFIRMATION | EXPOSURE OCCUPATION 1 | LEVEL I 1 11 Yea |Exposed in Various 1ob| |aoae degree In PVC Jto 22 planes from (chemicals cold rooe to* |but Bain paste | expoaure recovery to |was to VCH, PVC charging! |probably operator to Jhlgh paste 15 OTHER CAREER HIGHLIGHTS 1 i 1 | 1 J 16 OTHER COMMENTS JR Kaminski lleeter of J26/2/79 and (Prof. Taaburro 11et ter of 19/ 1/79 1 | ( 1 charging. 1 Ill August | 1965. 1 Terminated | employment 1 | 1 I i 1 20 |25.H.78 1(HlOfH (sty* 27 land C IDsily Haiti US) i Jan 1966 I Yea 1 High Operator to (Exposure In JR N Wheeler I 10.10.76 IbuLk and 11 tr of 4 Jan 1 Idleperalon PVC|I979 and 1 (manufacture | Charles ton 1 IDaily Mall 1 130.11.78 and |R Kami nek 1 34 1 3t |03.1 l.)4 i Ye* 126/2/79 1 lletter of i 38 1 16 101.03.80 Yea i i (6/4/79 fR Kaminski ILettera of 17 1 15 130.12.80 i i Yea |6 - Unknown Maine enance * 19th June J980 I14 5th Nov I960 |9 - Minimal Mechanic 1 6 yre 1 Elsewhere t i i... 35 1 13 *02.04.82 I U yre | Boiler house| [ 1 i Operator 1 1 9 yre I Yes (High (But Chemical IFrom 1959 to |Br Dacey Jnot aa high Operator In 976 A1Iphatlc|letter | a a reactor Icleaner |would cha rge reactor Chemlcala 116.Id.HI and operator and | Sl H Wheeler from July I976|letter of |e xperlenee) to da |9.J l.8i. (Worked as Foreman I Alt>o Dr Dacey J J abtmrer Aj Iphat 1c IJ et ter of 11 ton 3ier*J ra J HI re b'ENC 0 0 j j) s I June 1941 | E ii May 1946 lperat loci | J at u of death. | did nay | have 1 Page USA Sheet 6 30 IC1 CHEHICALS & POLYMERS LIVER Angiosarcoma Cases - (Review Date: I Jan 1988) UJC system of dates DAY - MONTH - YEAR WPX/ASL_2 - LANG10CASES,5 l 12 3 4 i5 6 7 8 _______ COUNTRY AND | NAME OR REFERENCE | INITIALS NO DATE OF BIRTH US 32 |C U Giroux 22-02-06 COMPANY | FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS j Monsanto Springfield l5-10-5L | Has* ______________ 00-07-79 7L US 33 j |S Ferguson 08-10-27 | Jnr RFC i |Loulavll a 139-09-54 L1-05-82 54 US 34 | Nr Byrus 24-01-34 RFC j ILoulavll e 1955 03-11-82 48 US 35 US 1A ______________ j 09-03-12 UCC IS Charle- 23-07-44 (ton ______________ 18-07-83 71 27-OB-32 rhe Genera IAshtab Tire and |Ula lubber Co |11-06-56 21-08-83 50 !i 9 YEARS OF EXPOSURE TO DIAGNOSIS 28 28 27 39 27 11 11 10 | 11 | 12 1 13 1 14 $ 15 1 16 !1 11 t1 11 YEARS OF | DATE OF | HISTOLOGICAL | ESTlHATED 1 1 EXPOSURE | DEATH | CONFIRMATION I EXPOSURE 1 OCCUPATION | 11 | LEVEL I 1 OTHER CAREER HIGHLIGHTS 1 1 1 i OTHER COMMENTS 11 JJ tI 14 117-05-80 ( An autopsy (The death 11940-1951 J (In PVC 1 | was done and IcsrtlfIcatelVarloua Jobs) autoclave 4 l Immediate (gave Jin potyaer | area) | | cause of |Hr Clroux1 taanufacture | | | death given |usual IBUTVAR | 1 1 A* (occupation |LUSTREX | 1 pAnglot.^. ..ma *1 aa "bettl e|1951-1964 | 11 loperator** (Various Jobs| i1 jin |in and | 11 |** cheat cals (around PVC J 11 |Industry**. lautoclaves | J1 11964-1973 lf ii IVarloua | ij Iclertcsl | it (Jobs In PVC | ii IpoLymerlaatIon i( |facility/ 1 1 I Information (given In lletter of 24 (February 1982 1froa Dr lWalter C IBarnes of JHonsanto ISprlngfteld to |Dr A Munn of (Monsanto |Eu rope. t I 1 j | ii ii Ii 28 (Alive | Yea i | Retl red 101-03-73. (Multiple | 1 ( l 1 J 1t Hobs | lletter of 11 tlncludlng l 112 Aug 1982 * 11 1Foly | 1 Dr M N Johnson JJ lOperator * | (letter of !1 i J Polycleaner.I 128 Feb 1983. 11 1 1 LO 104.08.83 |Yea iPoly 1965 left BFC |Dr H N Johnson 11 (Operator * |to become a lletter of 11 (Autoclave Clergyman. 13 Nov 1982, ll (Cleaner 1 |28 Feb 1983 1f 11955-65. 1 land 9 Aug 11 1| 11984. !1 ii 14 118-07-83 | Yea 11 11 i\ ti 27 |Altve | Yes 1 f (High froa 1 11944 to t | 1955. 1 |Medium froa| 11955-1958 1 \ (Moderate 11956-56 1 I J | J | 1 | t 1 1 (letter of |5 Sept 1983. ( f 11 r( 11 |labourer l 11956-57 | Iprod Helper | (letter of 1 12 Sept 1903: Ispucted at 11 11957-70 | (medJca 1 loperator | |Ha^9ftl. GENC u 0 610 6 ii 11970-75 | lelet't Ml I dll | | 1 975-pn-i.tHH J i'MU'i *i i h^^Hed IHa^WSd i Page USA Sheet 1 JC( CHEMICALS 6 POLYMERS LIVER Angloaarcoaa Case* - (Review Dace: 1 January 1980> WPX/AS12 - LANGI0CASES.6 UK aye tea of daces CAY - MONTH - YEAR t1 1 2 1 3l 4 1 5 16 )1 1 1 7 ) B 19 i 1 10 1 u 1 13 ( 14 ii 1 15 | J1 t1 COUNTRY AND INAHE OR I DATE 0P1 REFERENCE |INITIALS! BIRTH ( NO \ \ Ji 1 1 11 1 1 (YEARS OF l (HtSTO- 11 | FIRST VC |DATE OF |AGE AT | EXPOSURE |YEARS OF| DATE OF |LOGICAL |EST[MATED! (OTHER COMPANY 1 FACTORY | EXPOSURE |D1ACN0SIS|DIAGNOSIS!TO (EXPOSURE! DEATH |CONFIRM-!EXPOSURE OCCUPATION |CAREER 1 1 | j li |DIAGNOSIS! 1 |ATION J LEVEL 1 |HIGHLIGHTS! OTHER COMMENTS t... - . f USA 1 1 J1-- 1 1 __ j1 1 ! l 11 11 lHr J |29.08.291 RFG 1 Louis- ( 1953 106.08.84 ( 54 1 31 | 22 106.08.84 I Yea 1 High | Worked |Payton 1 1 Ivllle 11 1 1 (regularly | 1 1 Information given In Letter 09.OS.84 | froe Dr H N Johnson \1 \1 1 1 (In PVC areal | 11 J1 ( 1 |In the | | 11 1t 11 i1 i 1J 1 11 1 1 i i (early days 1 was a J | reactor | 1 I | 11 11 1 l Jcleaner | j 11 11 t i 11953-75. I JVB \f 11 U8.08.221AU | |Products (Calvert IClty J1 11 100.02.63 |19.01.84 1 1t _J 1 6L ( 1 l1 l 20 t 20 128.10.83 1 Yea 1 High | Kora* 1 t 1 1 11963-19821 progression! I 1 Throtsbo cytopenla and leukopenia since since 1978. Cold treataent for arthritis | 1976. Under Dr's care about 6 sooths 11 11 1 !1 11 t1 \1 11 ( 1 1 1 1 J t 1 |froa helper! (to senior 1 loperstor. Icleened i ( before death, had passed standard physical i examination 1 months earlier. J harr letters of 22.10.84 and 23.01.85. 1 1 t1 11 1 J1 t 1 1 Ireectors, t letrlpplng | 1 | 1 11 1 ( land l 1 1 l1 1 1 (recovery | | 1 Jt 1 1 lareas as | ( 1 fi 1 1 Iwell as | | 11 1 l1 1l t 1 J t (charging t loperator. 1 i_________ ________________ Jt-- -J 1 11 1l 1 |J Meal cel27.06.18|Pantasote (Passaic 1 1960 | March ( 65 1 24 1 |1984 | 1 1 i1 1 1 111 j_________J J 1 23 129.06.84 1 1 1 i 1 Yes | Low Ji 1| 129.09.60 - (Worked IMay 66 Ibefore (Vinyl 11960 |Fabrication!with US i | Never In hospital for any chronic or ( acute aedlcal probleas. Death certificate | states cause of death cardlo--pulaonary (iarrest secondary to anglosarcoas of | ver. 1 11 1 1 1 Plant (Air | Letter of 15.07.66 froa John E Ertel 1 11 I 1 1 Hli?h |May 66 - (Porce, |cof Pantaeote with letter of 24.02.86 1 111 ( (Aug 70 |United ( froa Dr Auerbach, Pathologist. 1J 1i 1 1 1 Utility IWool 1 1 11 1 1 |Resin | Dyers ( 11 111 1 1 Operator land ( 11 111 1 tlinc Jul 66|0ksnlte | 11 i1 1t *1 1 1 1 1- Sep 67 | Reactor 1 1 | l i( ii iil I 1 (Operator) f f 1f 1 1 | Lou I Sep 70-82 I 1 ii 1l 1 1 t Horoiib r I | 1i 11 fl 11 1 1 i 1 |Operator 1 | Low | 1 9H7--H 1 1 j | GBrtC 00* i0< 1I 1j 1 1 |MI 1 1 f 1 11 1i i f |Opertor , 1 1 11 1l i \ | Cu l c.icL, i 1 i 11 11i 1 (Shop, uM ll| j t* ii 11i 11 l 1 1 .. ...................... | 1 Page 32 OSA Sheet 8 ICl CHEMICALS 4 POLYMERS LIVER Anglosarcoaa Casea - (Keylew Date: I January 19B8) WPX/ASL2 - LANCIOCaSES.? UK ayatea of dates DAY - MONTH - YEAR 11i 1 J 1 2 1 3 t 4 | 5 1 6 i i 1 8 1 9 1 io 1 U1 J 13 | 14 ( 1 15 1 lb JL 11 COUNTRY ANO (NAME OR | DATE OF| REFERENCE (INITIALS| BIRTH | NO I 1 J l J 1 j________ 1 (YEARS OF J_______ f (HISTO- 1 1 I 1 11 1 |FIRST VC |DATE OF | AGE AT (EXPOSURE 1 YEARS OF| DATE OP |LOGICAL | ESTIMATED) |OTHER COMPANY | FACTORY |EXPOSURE |DIAGNOSIS)DIAGNOSIS!TO (EXPOSURE! DEATH |CONFIRM- |EXPOSURE |OCCUPATION (CAREER 1 1( | DIACNOSI S| |ATION 1 LEVEL 1 (HIGHLIGHTS! OTHER COMMENTS USA AO J| L| IP P 126.10.141 BFG ICllaer I J1 11 (1 11 J i J 1 j________ J1 | i 1 1 1 1 \ 1 J_____ 1________ (1 (Louie- (22.05.42 ( 198? t 22 1 45 l 14 103.01.87 1 Yea | Nigh |Cheat cal ILetter froa Dr Diet*, RFC, (villa 1 | 1 1 11942-197A|Worker 1 (10.3.87 11( ( 11 11942-45 1 1 111 1 1 1 Low | 11 111 | 1 11975-I976)Foreaan 1 1 111 l 1 1 |1945-76 1 l JL J1 1L 111 A L (R Buckley 7 1915 J Goodyear INlsgara (T Ute | 1967 1 22 11 1 | 1940'* 1 11 111 J 1 | ? 40* 1 T 30 | approx 1 Alive i 1 1 T Yea 1 1 J________ i__________ 1 11 1 11 1 1t 1 11 1 1 1 ILetter froa Prof Taaburro |University of Louisville J 11 1J1 1 11 t 1 11 J________L 1t1 JJJ ( J_______ i 11 1 J1 ( 1 J I GENl- 00.51 OS Page 33 YUGOSLAV[A COUNTRY AND REFERENCE NO NAME OR INITIALS CATE OF SIRTH [Cl QlbMjCALS & POLYHEKS LIVER Angioaarcoaa Caeee - (Review Date: 1 Jan 1988) 12 YEARS OF FIRST VC CATE OF ACE AT EXPOSURE YEARS OF EXPOSURE DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE LEVEL OTHER CAREER HIGHLIGHTS WX/ASL - LAKClOCASES.il OTHER COMMENTS Jugo Vtnil Spilt 1 02 I i m.i 1 * 311Jugo [ Split 11 1 100.00 50J12.07 73 i l 42 | [ 23 1 t1 18 112.07 73 | l Yea* 1 1 IVinil 1 1 1 i 1 1l i1 1 1 111 1 1 1 1 i1 1 1 1i1 1 J 1t i l i 1 11l 1 1 11 i1 t . .]. -- -1 - 1 _l _J_______ _____L_ l 1- -1 .. _____L._ j . t ,06.30 jugo Vinil Split 15.12.58 03.09.78 1i | VCH * (Production 1 11 1 11 ! J_______ SAR1C et al paper Env Health Perspective VoV 17. PP J89-J92 J976 1 I * In hie letter of 3 Oct J978, Or Splrtaa of |NIOSH changed the etatwa of Case 02 to VCH (production employee. Dr Splrtaa aleo |notIf led a new Caae 03 aleo a VCH production (worker. i_____________________________________________________________________ Rage Kaainekl letter of 19 June I960 end IARC letter of l April 1982 bENC 0061 O'* Page 34 TABLE\_ (Review Date - 1 Jan 1988) Incidence of ASL Cases Per Annum By date of death 1955 ............................................................................................. 1 60 7 ............................................................................................. 1 8 ................................................................................................0 90 1960 ................................................................................................0 1 ............................................................................................. 1 2 ............................................................................................ 1 3 ............................................................................................. 0 4 ............................................................................................. 2 5 ............................................................................................. 0 6 ................................................................................................0 7 ............................................................................................. I 8 ............................................................................................. 5 9 .......................................... 3 1970 ............................................................................................. 2 1 ............................................................................................. 3 2 ............................................................................................. 5 3 ............................................................................................. 8 4 ...................................................................... .,.................... 5 5 ..............................................................................................11 6 .............................................................................................. 11 7 ............................................................................................. 9 8 ....................................................................................... 10 95 1980 ............................................ 10 1 ............................................................................................. 5 2 ............................................................................................. 3 3 ..............................................................................................10 4 ............................................................................................. 7 5 ............................................................................................. 6 6 .................................................................................... 3 7 .......................................................................................... Total 129 H,B. 1 Does not include Italian 01 but does include German 03. 2 The 1977 total includes US case 24 which is a (^^angiosarcoma. GEWC 006110 3 Does not Include the following who are stilt a^We, so far as known: Cant l, Pel 5 6 22, 03! 6 12, IIK14, IJS11, In {, Page 35 Distribution of ASL Cases by Country (Review Date - l Jan 1988) TABLE 2 USA W Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway 38 *** 31 ** *** 22 *** \3 *** 12*** 5 **** 5* 4 ***** 3 2 2 1 Total 138 * Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholangiosarcoma; S, Canll, Frl5 & 22, G31 A 32, UK14, US33, 36 & 41, who are still alive, so far as known. **** Includes one monomer worker. ***** Includes two monomer workers. i.e Western Europe North America Rest of World 79 50 9 G^C r,r Total 138 WPX/ASL2 - LANGIOCASES,10 Page 36 Pattern of ASL Cases by Factory TABLE 3 (Review Date - t Jan 1988) (a) U Europe Of the 79 cases in W Europe, 68 have occurred in clusters at 12 factories. Of the 31 German cases, 28 have occurred in clusters at A factories. . ASL Cases Dynamit, Troisdorf, Germany BP, Barry, UK Hacker, Burghausen, Germany Atochem (formerly Chloe Chimie, formerly RP), St Fons, France PCUK, Brignoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Gerraany ICI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium Atochem, St Auban, France 12 10 9 8 7 5 4 3 3 3 2 2 68 KB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) H America Of the 50 cases in N America, 42 have occurred at four factories out of a total of 55 factories. In N America 43 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawlnigan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 10 5 42 NB: The re are 29 pre 1962 PVC plants in N America; 12 of these have had ASL cases (Ref Tables 9 6 10) (c) Rest of World The 9 ASL cases are believed to be in one cluster of and two clusters of 2 cases, gemc /ASL2 - LANG10CASES, 1 1 *L1 Page 37 TABLE 4A Latency Periods (Years from first Exposure to Diagnosis) (Review Date - 1 Jan 1988) W Europe N America Country Belgium France Germany Italy Norway Sweden UK No of Cases 2 22 31 5 1 5 13 79 Total Years 35 574 632 99 22 122 293 1777 Average 17.5 26.09 * 20.38 * 19.8 22 24.5 22.53 * 22.49 W Europe Average Rest of World US Canada 37 955 25.81 * 10 205 20.5 * 47 1160 24.68 N America Average Summa El Czechoslovakia Japan Yugoslavia W Europe N America Rest of World 2 3 4 9 79 47 9 135 30 59 85 174 1777 1160 174 3111 15.0 19.66 21.2 19.33 Rest of World Average 22.49 24.68 19.33 23.04 * World Average GENC 00611 th > below world average! . 10 cases, France, and USA have an average latency period above world average; Germany, UK and Cai Canll or 12, or US41: details not known. Page 38 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1988) 11 11 1 0-9 yrs | 10-14 yrs 11 11 Belgium 1 1 1 1 Canada ** Czechoslovakia f 13 1 11 France Germany Italy 1 1 11 1 15 1 1 Japan 1 11 Norway Sweden 1 \ 1' 1 1 1 UK 1 t USA ** 1 \ l 12 Yugoslavia 1 1 1 1 11 TOTAL ** 11 11| 12 11 1 1 15-19 yrs | 1 1 1 21 1 1 1 1| 1 41 1 91 1 2t 1 1| \ \ 1 21 1 5\ 1 7j i i i i 33 | 1 1 1 20-24 yrs | 1 1 t 1 1 5| l 1 1 31 1 10* | 1 21 1 21 1 1 i 1 1| 1 91 i 4! 1 1 37 1 1 t 1 25-29 yrs 1 1 1 1 1 2 8 5 11 1 21 1 4 81 1 1 | 1 30 1 1 30-34 yrs 1 1 1 1 1 1 1 3 2 1 11 2 5 1 1 ! t 13 i i 11 11 35+ yrs || 11 11 1I 11 11 11 11 \1 1 3 || 11 J1 1 1l 1i 11 1 1\ 11 11 If II 11 6 \1 11 11 11 11 9 11 11 Total 2 10 2 22 31 5 3 1 5 13 37 4 135 1 I Average I Latency I Period ((Table 4A) 1 1 17.5 1 1 20.5 \ | 15.0 1 1 26.09 1 1 20.38 1 1 19.8 1 j 19.66 1 | 22 J 1 24.5 1 1 22.53 f | 25.81 i I 21.2 1 1 I 23.04 1 * Includes G 03 aerosol can filler ** Does not include Canll or 12, or US4 1 : details not known G0C 006114 IASL2 - LANGIOCASES,13 Page 39 (Review date 1 .January 1988) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE | YEAR OF | LATENCY PERIOD | ARITHMETIC MEAN 1 LATENCY PERIOD 1 FIRST EXPOSURE | (NO OF YEARS) | OF LATENCY PERIODS 1 11 48 | 1939 1 38* 1 | 1 1 47 | 1940 1 1 289 - 36.12 1 46 I 1 1 37,21,37,41 |8 1 45 1 2 1 32,38,45 | 1 44 1 3 1 38,14,32 | 1 1 4 I 28,11,24,20,24,34,39 | 718 26.59 I 1 5 1 27,22,28,29 | 27 1 1 6 I 21,29,31,26,28,15,23,1 I 1 1 30,35 40 I 7 I 29,24,29,28 | | 1 1 39 1 8 1 28,24,34 | 1 I 9 1 30,26,20 | 521 - 24.80 1 1 1950 I 26,22,31,19,23,14,33 1 21 1 I 1 I 19,28,17,28,34,29 | 1 35 1 2 1 21**,15 | 34 1 3 1 25,22,23,22,20,31,22,1 1 1 1 1 32*** | 1 4 1 21,21,25,25,21,28***,| 1 1 1 22 | 787 = 22.48 1 ! 5 1 22,23,24,14,19,21,27 | 35 1 1 I 27*** 24,28,30*** | 1 1 6 1 21,12,27*** | 1 30 I 7 I 19,17,15,13,16,28 | 1 29 I 8 1 18,18,15,17,20,29*** | 1 1 9 1 16,21,25,27 | 544 at 18.75 1 I 1960 1 13,18,21,25,24,25 | 29 I 1 1 15,16,16,16,19,19,12 | 25 1 2 1 13,18,17,12,18,21 | 24 1 3 1 16,17,20,21 | 1 1 1 1 1 4 1 16,17 | 221 a 17.0 1 I 5 1 11,19,20 | 13 1 1 6 1 9,18,21*** 20 | 7 1 16 | I 1 1 19 1 8 1 18 | 1 I 9 1 13 I 31 15.5 1 1 1970 t V 12 1 VIOLA 1 15 1 2 ! 14 1 3 i 11 11 i 1 MALTONI ! 4i i 1 GOODRICH 1 TOTAL 1 135 CASES | 3111 = 23.04 1 11 1 135 1 * Cholangiosarcoma ** Aerosol can filler *** The following are still alive, so far as known Frl5 and 22, G31 and 32, UK14, US33 and 36 NB: Does not include Canl1 or 12, US41: details not known WPX/ASL2 - LANGIOCASES,14 GEMC 006115 TABLE 4D page 40 (Review date 1 January 1988) LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION " MAX POSSIBLE I YEAR OF I LATENCY PERIODS IN LATENCY PERIOD 1 FIRST EXPOSURE | WESTERN EUROPE | NORTH AMERICA 1 48 1 1939 1 1 1 1 38* 47 1 46 1 1940 1 1 I 37,41 1 | 21,37 45 1 44 1 21 3 1 38 1 32,38,45 | 14,32 1 4 1 28 1 5 1 27 | 11,24,20,24,34,39 | 22,28,29 1 40 ! 6 1 21,29,31,33 7 1 29 | 26,28,15,23,30,35 | 24,29,28 39 1 8 1 28,34 | 24 1 9 1 30,26 | 20 1 1950 1 26,22,31 | 19 1 1 1 19,28,34,29, | 17,28 35 1 34 1 1 2 1 21** 3 I 25,22,22,32*** 4 I 21,21,25,25 | 15 I 23,31 I 21,28*** 1 5 1 22,23,24,27***24,281 14,19,21,27 1 1 30 1 | 30*** 6 1 21,12 7 1 19.17.15,13.28 | | 27*** I 29 1 8 I 18,18,29*** | 15 I 9 1 16,21,25,27, | 1 1960 I 13,18,21,25,25 I 24 1 1 1 15,16,16,16,19,19 | 12 25 1 24 1 2 I 13,18,17,18,21 3 1 16,17,21 I 12 | 20 1 4 1 16 | 17 1 5 1 11,19 I I 20 1 6 | 9,18,21*** 7 1 16 | I 19 1 8 1 18 | 1 9 1 13 | 1 VIOLA 1970 1 1 11 2! I 1 MALTONI 3 1 TOTAL CASES 1 79 | 47 * Cholangiosarcoraa ** Aerosol can filler *** The following are still alive, so far as known Frl5 and 22, G31 and 32, UK14, US33 and 36 1 ROW 1 1 1 I 1 1 1 1 1 1 I 1 1 23, 14 1 1 1 22,20 22 1 1 1 1 16 1 17,20 1 1 1 1 1 1 1 20 1 1 1 1 1 1 1 1 19 NB: Does not Include Canll or 12, or US41: details not known WPX/ASL2 - LANGIOCASES,15 TABLE 4E Page 41 (Revi ew date 1 January 1988) 1i 11 PLANT 1 START i LATENCY PERIODS OF ASL CASES 1 NO OF | AVERAGE 1 UP i IN SPECIFIC PLANTS 1 CASES | LATENCY PERIOD I DATE i (10 OR MORE CASES) 11 1i 11 1i 11 LOUISVILLE 1 1940? i 12,14,15,19,19,20,24,27,28,28,28,29 ,29 | 15 I 24.53 yea USA 1 i 31,45 11 TROISDORF W GERMANY 1 1 1954 i I 12,13,16,16,18,19,19,21,23,25,28,29 i 11 1 12 1 11 19.91 11 I1 SHAWINIGAN I 1943 1 11,12,14,21,22,23,24,24,26,28 1 10 I 20.5 CANADA 1(1941?) i 11 1I I1 S CHARLESTON 1 1939? 1 24,30,32,32,34,35,37,38,38,39, 1 10 I 33.99 USA ii 11 11 11 BARRY I 1948 1 9,17,18,28,31,33,18,19,18,21 1 10 | 21.20 UK i i 11 MB: Does not include cases Canll and 12 at Shawinigan: details not known WPX/ASL2 - LANGIOCASES,16 ~ UQ,ill? Page 42 TABLE 4F (Review date 1 January 1988) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) YEAR OF FIRST | LOUISVILLE | TROISDORF | SHAWINIGAN 1 S CHARLESTON 1 BARRY EXPOSURE I USA I W GERMANY I CANADA 1 USA 1 UK 1939 1 1 1 1 38 1 1940 I 1 11 1 11 1 1 21 1 37 1 21 1 1 1 32,38 1 31 1 1 14 1 32 1 4 I 20 1 1 11,24 1 24,34,39 1 5 1 28,29,27 1 I 22 1 1 61 1 1 26,28 1 30,35 1 7 I 29,28 1 1 24 1 1 8 I 24 1 tI 1 91 I 11 1 1950 1 19 1 1I 1 31,33 11 1 29 1 1 1 28 2 1 15 1 11 1 3 1 31 1 I 23 1 1 4 I 28 1 21,25 5 1 14,19 I 23,28 1 1 1 1 1 1* 61 1 12 1 1 1 71 1 13 1 1 1 81 1 !1 1 91 1 !1 1 1960 1 1 11 1 11 I 16,16,19,19, I 12 1 1 2 1 12 31 1 18 1 1 1 1 I 1 18 1 | m 41 1 11 1 51 1 11 1 19 61 1 11 1 9,18,21 71 1 11 1 81 1 11 1 18 91 1 11 1 1970 1 1 11 1 11 1 11 1 21 1 11 1 NB: Does not Include cases CanlL and 12 at Shawinigan: details not known WPX/ASL2 - LANGIOCASES,17 t3HC 006113 Page 43 TABLE 4G (Review date 1 January 1988) PLANT | | 1 BURGHAUSEN | W GERMANY | ST FONS FRANCE 1 | ( BRIGNOUD FRANCE 1 | | SUNDSVALL SWEDEN 1 f | NIAGARA USA J I | 1 SPLIT 1 YUGOSLAVIA! 1 MARL | W GERMANY | 1 START-UP DATE |LATENCY PERIOD OF ASL CASES |IN SPECIFIC PLANTS(4-9 CASES) 1933 1 I 17,21,22,25,24,13,21,32,30 1 1939 1 | 21.28,29,37,38,27,41,34 i 1950 1 | 11,16,18,26,30,25,34 i 1945 1 1 16,19,27,29,31 1 1947 1 I 15,17,21,23 i 1950 i 1 20,20,22,23 t 1948 1 | 15,16,22,21 i i NO OF | AVERAGE PERIOD CASES 1 9 1 22.77 years I 1 8 1 31.88 i 1 7 1 22.85 1 1 5 1 24.4 1 1 4 1 19 i i 4 1 21.25 1 1 4 1 18.5 i i NB: Does not include LTS41 (Niagara): details not known WPX/ASL2 - LANGIOCASES,18 006U9 Page 44 (Review date 1 January 1988) TABLE 4H LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) " = YEAR OF IburghausenI ST FONS 1 FIRST EXPOSURE 1 W GERMANY1 FRANCE 1 1 11 1939 1 1 11 1I 1940 1 2 1 1 1 1 1 37,41 1 1 1 1 31 41 1 38 1 1 1 51 61 71 81 1 1 29 1 1 28,34 1 1 1 1 91 11 1950 1 2 1 1 1 11 11 11 3 125,32 | 1 4 121 1 1 5 122,24,30 1 27 1 61 7 1 17 81 91 1 21 I 1 1 1 1 1 1 1960 121 | 1 11 11 21 31 41 11 11 11 51 61 71 81 1I 11 11 11 9 1970 I 13 1 1 1 1 1 11 21 11 1I 1 I1 BRIGNOUDl FRANCE 1 1 26,30 34 18 16,25 11 SUNDSVALLl SWEDEN 1 1 1 1 1 1 1 1 1 27* 1 31 1 29 1 1 1 1 19 I 1 1 1 1 1 1 1 1 1 1 1 1 16 1 1 1 1 1 1 1 1 I 1 NIAGARA I USA 1 I 15,23 I 17 1 I 21 I SPLIT 1 MARL YUGO- IW GERMANY SLAV!A 23* | 20 I 22 22* 20 115,16 121 *Monomer worker NB: Does not include US41 (Niagara): details not known WPX/ASL2 - LANGIOCASES,19 0ENC 006V20 Page 45 TABLE 5 (Review Date - 1 Jan 1988) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 1986 1987 TOTAL 1i | Western Europe | North America 1 1 1 1 1 1 I1 1 i1 |1 1 i1 I1 I1 I1 I1 1 |5 i2 I1 Il 14 |1 t2 |1 14 13 12 i6 16 16 17 I5 -t 4 13 13 12 | 16 14 I5 1o I1 17 12 13 I5 12 15 1 13 1 1 |1 j 74* ** 1 46** Rest of World 1 3 1 2 1 - 1 9 Annual Total 1 1 1 1 2 1 5 3 2 3 5 8 5 11 11 9 10 5 10 5 3 10 7 6 3 1 129 ( Cumulative 1 | Total | Key Events 1. 11 12 13 14 16 |7 1 12 1 15 1 17 | 20 1 25 | 33 1 38 f 49 | 60 | 69 1 79 I 84 | 94 I 99 I 102 | 112 f 119 1 125 | 128 | 129 1 1 1 1 1 1 1 1 I 1 | Viola 1 1 | Maltoni | Goodrich 1 t 1 t 1 1 1 1 1 1 1 1 1 * Includes G03 aerosol can filler but omits It 01 bag extruder ** Does not include the following who are still alive, so far as known: Canll, Frl5 and 22, fill 4 32, UK14, US33, 18 8 41 1 | 1 1 1 1 1 1 1 1 1 j 1 1 | | 1 1 1 1 t 1 1 1 1 1 t 1 1 SENG 006121 WPX/ASI.2 LANG 1OCASKS , 20 Page 46 TABLE 6 (Review dace l January 1988) ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It.01) KEY 1 i1 EVENTS 1 I WESTERN EUROPE I NORTH AMERICA 1 REST OF WORLD| 1 11 1 11 1 1955 1 Cl I 11 7 | C2 1 18 i1 I9 iI 1 1960 1 11 1 US8 1 12 1 C3 1 13 11 14 1 US5 1 Cz2 | 11 6 11 1 7 1 FI 11 18 1 C4,C5,US4,US7,US10 1 1 9 1 G1 1 US12.US16 1 Viola 1 1970 1 Swl 1 US11 1 1 1 I G2 I C6.US2 I 1 2 I N1,Sw2,UKl ,It2 1 C7 1 Maltoni 1 3 I G3** I C8,US1,US3,US23 1 Y1,Y2,Cz1 I Goodrich 1 4 | G4.G5.UK3 I C9.US13 1 1 5 I F2,F3,G6,G7,G8,It3 I US6,US9,US18,US26 1 Jap 1 | 1 6 I Bl,F4,F5,F6,F7,Sw3 I US19,US20,US22, 1 Jap2,Y3 ^ 1 7 I F8,F9 ,G10,G11,G12,Sw4 1 8 I F10,F11,G9,G13,G15 I C10,US21,US24* I US27.US28 1 Y4 1 ^m 1 I G16.G17 1 I 1 9 | F12,F13,UK4,UK5,G18 1 1 1 1980 I UK6, UK7,G19,Sw5,G20,G21US | US17, US29, US30.US32 1 1 1 I It4,F14,UK8,G22,G23 1 1 1 2 I G26 I US31.C12 1 1 3 I UK09,It5,F17,B2,G24,G25,G30| US35, US34, US38 1 1 4 1 UK10, F16, F18, G27.G29 I US37.US39 I 1 5 I UK11, UK12,FI 9,F20,G28 1 1 Jap3 1 I 6 I F21,UK13,It6 1 1 17 1 Total 1 74*** I US40 h 46*** 1 19 1 1 11 * Cholangiosarcoraa ** Aerosol can filler *** Does not include the following who are still alive, so far as known: Frl5 & 22, G31 & 32, UK14, US33, 36 & 41 Canll, WPX/ASL2 - LANGI0CASES.21 GENC 006122 Page 47 (Review date 1 January 1988) TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01) KEY | EVENTS | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 t 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Viola 1 I 1939 40 1 2 3 4 5 6 7 8 9 50 1 2 3 4 5 6 7 8 9 60 1 2 3 4 5 6 7 8 9 70 I 1 | WESTERN EUROPE 1 1 11 11 11 1 IFrl1,Fr 16 1 1 1 1 Fr 14 1 1 1 UK1 1 Sw2 |Frl,Fr3,Sw4 1 1 1 1 Sw3 1Fr9, Frl7 |Frl2,Fr4 1 1 1 |Fr7,N1,UK8,UK9 1 ISwl,UK5,Fr20,G30 1 | G3** 1 |G15,It3,G26,G31*** 1 |G7,G8,UK4,G19 1 I Gil,G16,G18, Frl5*** IG23,G28,G32*** I FRIO,Gl 1 1 1 |Fr8,G4,It2,G2,UK12 |Fr6,Bl,Fr22*** 1 1 |Fr2,It4,Frl9,Fr21 1 |G5,G13,G25,G28,It6 1 |G9,G10,G12,G17,G20,G22| |G6,UK6,G21,B2,G29 IFrl3, UK7,Fr18 t 1 1 Sw5 |Fr5,UK11 IUK3, UK10.UK14*** | It5 IUK13 1 G24 1 1 1 1 1 ! 11 NORTH AMERICA 1[ 1 REST OF WORLD| 11 US24* 1| 1I C3.US27 US13, US29,US40 C2.US19 Cl ,C5 ,US5,US7,US28, US35 1 1 1 1 I I i I I | C4,US3,US9 1 C7 ,C9,US8,USl1,US21 ,US3 11 C6,US22,US26 ! USl 1 US12 1 USl 6 |Y2, US10, US32 1 US4 Cz2 1 1 1 1 1 1 1 CIO, US37 US18.US33*** US2,US17,US20,US34 US36*** US23 1 Japl,Y1 1Y3 1 1 1 ICzl 1Jap2,Y4 I | 1 1 1 I | US39 C8 US6 US38 US30 1 1 1 1 1 1 1Jap3 1 I 1 1 1 1 1 11 11 11 11 1I I Maltoni 1 31 11 1 Totall79 11 * Choiangiosarcoma (US24) ** Aerosol can filler (G3) 1 1 1 47**** 1 11 11 19 | 11 *** Frl5 & 22, G31 & 32, UK14, US33 & 36 are still alive, so far as known **** Does not include Canll or 12, or US41: details not known WPX/ASL2 - LANGIOCASES.22 OENC 006123 Rage 48 WPX/ASL2 - LANGIOCASES, (Review dace 1 January L988) TABLE 8 WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL CASES (PUTTING G03 & It.01) I START-UP| COUNTRY NAME | COMPANY NAf I LOCATION | ASL CASE NJMBER | YEAR GF | 1 YEAR I 1 1 1 I 1st Exposure | 1931 IWbst Germany IBASF I Ludwigshafen 1 1 I 1933 IWtest Germany |Wacker IBurghausen 104,07,11,15,23,24 157,54,55,53,55,69,60,531 1 1938 I Italy 1 IMontecatini 1 |Acna 125,31,32 1 155 1 | 1 1939 I France | Khorve-Poulenc/ |SC Fons 103,09,10,11,14 146,48,56,41,43, 1 1 iQoloe/Atochan 1 115,16,17 155,41,48 | 1940 1 United Kingdom |ICI/EVC I Runcorn (Closed 1948) 1 1 1 United Kingdom |ICI/EVC IHillhouse 101,04,12 144,54.57 | 1945 |&eden IKemanord/Nobel |Sundsvall(Stockvik) 101,02,03,04,05 151,45.47,46,64 | 1946 IFrmnce IRhone-Poulenc I Roussillon 101 146 I 1948 1 United KingdomlBP Qian/ICI/EVC|Barry 103,05,06,07,08,05 166,51,62,63,50,50 I 11 1 110,11,13,14 166,65,68,66 | IWest Germany |CHH/Huls IMarl 109,10,26,29 161,61,53,62 1 1949 1 Belgian ISolvay 1Janeppe 101,02 158,62 I 1950 I France IPCUK/Atochem IBrignoud 102,04,05,06,12,19 159,49,65,58,49,59,51 1 11 1 120 1 1 I France | Hicne-Poulenc/ |SC Auban 107,22 150,58 I 1 I Holland iChloe/Atochan 1 1 |Shell IPemis, Rotterdam 1 1 1 1 1 1Norway |Norsk IHeroya, Potsgrunn 101 150 I 1951 1 Switzerland ILonza/ICI/EVC ISins 1952 1 Italy IMontedison ITtemi 1 1 A 1 1 Italy IMontedison/EVC 1Porto Marghera 102,06 157,60 I 1953 1Austria IHalvic/Solvay IHallein 1 1 1 I France ISolvay ITavaux 108,13,18 157,63.63 | 1 Italy ISolvay I Ferrara 103 153 I |Spain 1 Rio Rodano IHemanl 1 1 1 1 United KingdomlBXL/BIP/NORSK lAycliffe 1 1 1 |West Germany IHoechst IGendorf 118 155 I 1954 IWest Germany | Dynamic Troisdorf 101,02,08,12,16,1/ 156,57,54,61,55,61, I 11 1 119,20,21,22,27,30 154,61,62,61,55,51 I 1955 1 Spain 1956 1 Spain IMonsanto IberlalMonzon iCaiqsa [Sabinanigo 1 1 1 1 1 1 1 I Hispavic/Solvay| Torrelavega 1 1 1 1958 IWest Germany ISolvay IRheinberg 1 1 1 1960 1 Italy IS C Ravenna/EVCIRavema 104 159 | IWest Germany ILonza/ICI/EVC IMaldshut 106,13,28 162,60,60 | 1961 I Italy |Montedlson/EVC |Brindisi 1 1 1 1962 1 Portugal I Cites IOporto 1 1 1 1965 I France |Rhone-Poulenc IMontlucon 121 159 I 1 Italy IPozzl IFerrandina 1 1 1 I Italy IPensac IMira, Venice 105 167 I IWest Germany IWacker 1 Cologne 1 1 1 1966 IWest Germany IHoechst | Knapsack(Frankfurt 105* 160 | 1967 I France I Spain lAtochem |Rio Rodano IBalan | Miranda de Ebro 1 1 1 1 1 1 (Greece |Esso Pappas IDiavata Salonika 1 1 1 1968 IBelgiun IBadiphil 1 Antwerp 1 1 1 1969 1 United KingdomlVinatex/Norsk IStaveley 1 1 1 I Italy IRunartLca/EVC I Cagliari Sardina 1 1 1 Continued GENC 006124 Page 49 Table 8 - Continued fcESIEEN EUROPE PVC PRODUCERS - START UP DATES vs ASL CASES (OMITTING GQ3 & It.OH 1 START-UP I OOUNnar NAME | COMPANY NAM | UXATICN 1 YEAR 1 1 1970 (Italy 1 |SIR 1 1 Porto Torres Sar 1 United Kingdom IICI/EVC I Runcorn 1 1971 I Spain I Hlspavic/SolvayIMartorell I Sweden 1 Ksnanord/Norsk I Sterlingsund I United KingdcmlBP Chan IBagLan Bay 1 1972 1 Finland IPekema ISvartback 1 Holland |D1 (Beek Limburg 1 1976 1 France |Soc Art D'vinyl| Mazingarbe 1 1 1977 1 Spain l(CDF) | (Monsanto IberialTarragona | 1982 1 West Germany I ICI/EVC |VosLapp 11 I Wilhelmshaven 1 ASL CASE NUMBER | 11 11 11 11 1 11 1( 11 11 11 11 11 11 YEAR OF 1st Exposure * Laboratory worker in Research Department WPX/ASL2 - LANSIOCASES.24 GENC 006125 (Review dace 1 January 1988) TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES 1 START-UP I COMPANY NAME LOCATION l ASL CASE YEAR OF 1 YEAR 1 1 1939? I *UCC S Charleston 1 NUMBER 1 1st EXPOSURE 107,13,19,21,24, 144,42,43,46,39, 1 127.28.29.31,35 I 4 1 ,44.42.46.44 | Dow Midland (made | 1 I 1940? I *BFG Saran copolymer) I Louisville 101,02,03,04,05, 148 ,55,45,52,44, 1 106,09,16,17,22, 162 ,45,50,55,47, 1 126,33,34.37,40 147 ,54,55,53,42 I 1946 |*UCC/Dow Texas City (Partially closed 1977) 1 1947 I Goodyear Niagara Falls 108,10,11,20,41 | 46 ,51.46,55,? 1 1948 1 Firestone/ Pottstown |12 149 I Occidental 1 I Uniroyal Painesville | 1 I 1950 I Monsanto (closed 1975) Springfield I |32 151 1 1 1952 1 Dow 1 BFG (Closed 1975 I Midland (No PVC since c 1975) Avon Lake 118 154 1 1953 I Diamond/BFG Deer Park | 1 1954 I General Tire/ ** Ashtabula 136 156 I DiversiTech (Closed 1984. Reopened 1986 by Vygen) 1 1956 1 Air Products Pensacola (Pace) I I Atlantic Refining Brooklyn(Closed late 1960s) I Borden Leominster (Closed 1984) 1 Conoco 1 BFG Hebronville (Closed 1975) Niagara | 1 I Great American Fitchburg |23 158 1 Plastics (Closed 1983) I 1 Hooker Hicksville (Closed 1980-81) 1 Pantasote Passaic(Closed 1984) 39 160 I 1957 I Atlantic Tubing | Tenneco/ Cranston (Closed 1967) Flemington NJ 130 1 159 1 Occidental (Closed 1985) 1 1 1958 I Keysor Century Saugus, Cal I 1 Air Products Calvert City(Paducah) 38 163 1 (Closed March 1982 Re-opened October 1983) I 1960 1 BFG Long Beach, Cal (No PVC now. 1 1 Borden Formerly shown as Watson) Illiopolis | 1 1962 I Tenneco/Occidental Burlington NJ I I 1963 I Conoco/Vista Aberdeen, Miss I I Stauffer Long Beach, Cal (Closed 1982) 1 1965 I Conoco/Olin Assonet, Mass (Closed by Olin 1975) I Ethyl Baton Rouge (Closed 1984) 1 1966 I Diamond/Georgia Delaware City | I Gulf 1 IGen Tire/Pantasote Mt Pleasant W Va |(Closed 1982) I BFG Henry, 111 | I Stauffer/Formosa Delaware City (Sold to Formosa 1981) I 1967 I Allied/Robintech/ Painesville, 0. (No PVC made by Robintech. I Georgia Pacific GP converted to polystyrene) I Hooker/Occidental Burlington NJ | 1 1968 1 Firestone/Occidental Perryville (Closed 1982) WPX/ASL2 - LANGIOCASES,25 Continued Page 51 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP I COMPANY NAME 1 1 YEAR | 1 1969 I BFG 1 1 1 1 Goodyear/BFG 1 1971 I Conoco/vista 1 | 1 1972 1 Nat Starch I 1 1973 I Borden | 1 1974 | Atlantic Tubing/ 1 1 1 Tallyrand 1 1 Shintech 1 1975 | Certaln-teed I I | 1 1 Georgia Pacific/ I 1 1 Georgia Gulf I 1 1 Tenneco/OccidentalI 1 1979 | Firestone/ I 1 1 Occidental 1 1983 I Formosa I I 1 1986 I -Vygen*_U_ LOCATION | ASL CASE Pedricktown NJ 1 1 NUMBER Plaquemine 1 Oklahoma City I Meredosia, 111 I Springfield | Cranston RI (Closed 1982) Freeport, Tex 1 | Lake Charles | Plaquemine, La | Pasadena, Tex 1 | Addis (formerly shown as Plaquemine) I Point Comfort, Tex| Ashtabula, Ohio I 1 YEAR OF | 1 1st EXPOSURE 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 * My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech, MB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL2 - LANGIOCASES,26 GENQ 006127 !. Page 52 (Review dace 1 January 1988) TABLE 10 CANADIAN FVC PRODUCERS - START-UP DATES vs ASL CASES 1 START-UP I I YEAR I 11 I 1943 I 1(1941?) I 11 11 1 1951 I 11 11 1 1957 1 1I 11 1 1966 I 11 11 1 1979 I 11 COMPANY NAME | 1 Goodrich (Formerly Gulf) 1 | | 1 Monsanto 1 I I Goodrich 1 | 1 1 Esso (Imperial Oil) | 1 1 Diamond Shamrock Alb/| BF Goodrich | LOCATION 1 ASL CASE 1 NUMBER Shawinlgan 1 101, 02,03,04,05 106, 07,08,09,10 111, 12 ! La Salle (Closed 1975) 1 1 Welland (? Niagara) 1 Sarnia 1 1 1 1 Fore Saskatchewan 1 1 1 YEAR OF 1 1st EXPOSURE 1 144,43,41,45,44, 147,46,61,46,53 1?,? 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES.27 006V2* Page 53 (Review dace 1 January 1988) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES 1 START-UP 1 COUNTRY NAME 1 COMPANY NAME 1 YEAR 1Pre 1939 I East Germany I State Company 1 1941 |Russia I State Coraps 1 1950 1 Yugoslavia IJugo Vinil 1 1951 |Czechoslovakia I State Comps 1 1955 |Easc Germany I State Comps I 1956 1 Rumania I State Comps 1 1957 1 Poland |State Comps I Rumania 1 State Comps 1 1958 1 Rumania I State Comps 1 1959 1 Hungary |State Comps 1 1961 I Rumania |State Comps 1 1963 I Yugoslavia lOhis 1 1965 1 Bulgaria |State Comps 1 1967 1 Poland |State Comps 1 1969 1 Russia 1 State Comps 1 1970 I Rumania 1 State Comps 1 Russia I State Comps 1 1972 1 Yugoslavia IVinilplastika 1 1975 I Czechoslovakia I State Comps I Russia (State Comps 1 1976 1 Yugoslavia 1 Hip 1 1977 1 Rumania I State Coraps | LOCATION 1 1 Schopau I Vladimir et al (Split |Novaky IBitterfeldt IIcechim ICsweicim (Dwory) ITirnaveni ITurda IRisnov IBerente Borsod |Borzestt |Skople |Varna |Tarnow IDjeriinsk IRimnicu Vilcea (Volgograd 1 Zadar INeratovice IKalush Area IPancevo (Rimnicu Vilcea | ASL CASE I NUMBER 1 1 101,02,03,04 101,02 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | YEAR OF | 1st Exposure 1 1 153,50,54,48 157.50 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGI0CASES.28 GENC 00612? (Review date 1 January 1988) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES 1 START-UP 1 COMPANY NAME I YEAR 1 1950 1 Chisso Corp I Kanegafuchi Rag I Tekkosha 1 1951 I Mitsui Toatsu 1 1952 | Mitsubishi Mon 1 Sumitomo Kag 1 1951 I Denkl Kagaku | Nippon Zeon I Toa Gosei 1 1955 | Ryo-Nlchi 1 1956 I Nippon Zeon I Nisshin Kagaku 1 1957 | Kureha Kasei 1 Shinetsu Kag I f 960 I Denki Kagaku 1 Kanegafuchi Kag 1 1964 1 Chisso Corp I 1966 I Tokuyama Seksui I 1967 I San Arrow Kagak I Sumitomo Kag I 1968 I Ryo-Nichi I Shinetsu Kag 1 1970 I Chisso Corp I Denki Kagaku I Kanegafuchi Kag I Kawasaki Yukl I Mitsui Toatsu I Nissan Kagaku I Shinetsu Kag 1 1971 I Tekkosha 1 1973 1 Asahi Glass I 1974 I Toyo Soda I 1975 I Central Kagaku 1 Toyo Soda 1 1977 I Unknown | LOCATION 1 | Minamata | Osaka 1 Sakata 1 Nagoya | Yokkaichi | Kikumoto I Shibukawa I Kambara | Tckushima I Uozu I Takoaka | Takeo | Nishiki 1 Naoetsu 1 Ohmi I Takasago I Chiba I Tokuyama I Tokuyama | Chiba I Mizushima I Tokuyama I Mizushima I Goi (Chiba) | Kashima | Kawasaki | Sakai I Chiba | Kashima I Yokkaichi | Hayatsuki | Sakata | Yokkaishi | Kawasaki I Yokkaichi | Kashima 1 ASL CASE 1 NUMBER 1 I 02 1 1 01, 03 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 YEAR OF 1 1st EXPOSURE 1 1 58 1 1 53, 65 1 1 1 1 1 1 1 1* 1 1 1 1 I 1 I fl 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,29 GENC 006130 (Review dace 1 January 1988) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS |START-UP I 1 YEAR 1 1953 1 I 1954 1 1 1955 | 1 1956 I I 1960 1 1 1 1961 I 1 1965 I 1 1966 I 1 1967 | I 1 1963 1 I 1970 1 I 1 1971 I 1 1975 1 1 1976 1 1 1977 1 1 1978 1 I 1 1 1979 1 COMPANY NAME Monsanto Mexica Policyd Gaon Do Brazil Elchlor/Solvay Electrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega SOC Paramonga Primex Policasa Petro Dow Polimeros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari | LOCATION | 11 1 Lecheria (Mexico) 1 I Mexico City (Mexico) | | Sao Paulo (Brazil) 1 I Sao Caecano (Brazil) I ICapitan Bermudez^Argentina)| I Mendoz (Argentina) I Cinco Saltos (Argentina) 1 Cartagena (Colombia) | Medellin (Colombia) | | 1 | I Mexico | | Paramonga (Peru) | I Puebla (Mexico) | | Managua (Nicaragua) | I Conception (Chile) | I St Martin Puebla (Mexico) | I Guyanilla (Puerto Rico) I EL Tablazo (Venezuela) 1 Tlazcala (Mexico) | Cubato (Brazil) 1 El Salvador I Coatzacoalcos (Mexico) | I I I I I I Camacari Bahia (Brazil) ( ASL CASE NUMBER I YEAR OF | 1st EXPOSURE 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,30 Page 56 ( Review dace 1 January 1988) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP YEAR COMPANY NAME Mid 1950s ICI Auscralia 1960s B F Goodrich Lace 1970s ICI AusCralia 1 LOCATION | I Bocany, Sydney | | Melbourne | | LaverCon | Melbourne | | ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE I 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES.31 GBC 006132 (Review dace 1 January 1988) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START-UP DATES START-UP DATE Sept 1986 COUNTRY NAME Saudi Arabia COMPANY NAME LOCATION National Plastic |Arabian Petrochemical Company Company IMadiant (Ibn Hayan) lAl-Jubail IAl-Sinahyah WPX/ASL2 - LANGIOCASES,3 2 Panel Country; COUNTRY AND REFERENCE NO NAME OK INITIALS DATE OF RlftTH 1C[ CHLHlCALS & POLYMERS LIVER Angloaarcoaa Gaaes - (Review Dace: I Jan 19..) 12 FIRST VC EXPOSURE YEARS OF DATE OF ACE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS _L DATE OF DEATH HISTO LOGICAL COHFI WH AT [ON ESTIHATED EXPOSURE LEVEL WPX/ASL - LANCtOCASES,32 OTHER CAREER HIGHLIGHTS OTHER COHMENTS hPMr