Document 2ROjKwN71gD3wb02GOzvx24ap

rnS'M^I3^*^ """ ilfc-n f. Cl l,*u Ilia Mil wiill-itiri-------fr isliiiiaii mr`- - i n i 65 Mutation Rctcarch, 87 (1981) 65--79 Elaevier/Nortb-Holland Biomedical Press This material may bo protected by copyright lav; (Title 17 U. S. Code), WV^yo i Univiisity Middletown. Connecticut $-'lt tCPEMC URL 05497 INTERNATIONAL COMMISSION FOR PROTECTION AGAINST ENVIRONMENTAL MUTAGENS AND CARCINOGENS 1CPEMC WORKING PAPER TGl/1 EPIDEMIOLOGICAL STUDIES INTO THE POSSIBLE CARCINOGENICITY OP HAIR DYES JOHANNES CLEMMESEN Stockholmigade 43, 2100 Copenhanen O (Denmark) (Received 3 April 1981) (Accepted 29 April 1931) Summary As emphasized by Wynder et al. (1963): "With too broad a defmnii.n of an occupation, increased risks for specific job categories can be overlooked. On the other hand, with rather restrictive definitions, it becomes unliki-iy that any study of limited size will yield significant results.". It follows that duration and intensity of exposure to hair dyes are difficult to determine and iiu- i.in ni period of a possible carcinogenesis is correspondingly difficult to dofim . It is against this background that investigators have worked. With Uu tion of Wynder et al. (1963), Cole et al. (1972) and Kinlen et al. (1977j, mcsi authors have restricted themselves to brief communications of nonsifinificnm results. Statistical significance is interpreted in most cases to be P > 0.005, v.hich * ll has bean agreed to publish this document as a workinr. paper for Task Croup \ ..r ih- tni. rn.i' tkmal Commission for Protection against Environmental Mutagens and Carcim>Kt*n<i <H l i ' i>' >. I views expreaaed are those ol the author and do not necessarily represent those of the Cumint w>m. They are published to stimulate discussion and comments, which will be weU-um>*<l by tl..All eorrtN>ondnce and reprint requests should b addressed to the secretary u( ICi'KMC P*ul HJtl. Uihmrn, Ph.D., Medical Biological Laboratory Th'O. P.f). box 4ft, SltHi) A \ H ti--^ut1 ''< Netherlandi). Tel. 15-138777. Telex 38034 ptm> nl. ICPhMC doc. 33-1081-15.7. 0165-1110/81/0000--0000/502.50 O 1981 Elsrvicr/NorthHoiiund Bionn-dn-.il I'm - 'fWVW 'P||f i