Document 2RJ6XBYd2Qxdbmj8ZavDo2gKL

COMPANY CONFIDENTIAL DISTRIBUTION /Reaearck Filea - 2 R. J. Fawcett - 3 R. W. Straaaburg R. G. Bauman M. R. Frederick C. F. Gibbe D. E. Ley H. J. Diatrick J. M. Kime J. S. Margar Patent Law Department Akron C. H. Stockman R. V. Yohe R. H. Wile on 5668 " r COOCEiCH CO. f 9 1969 RESEARCH LIBRARY QUARTERLY SUMMARY BIOACTIVE RUBBERS TEA FIRST QUARTER 1949 8. F. GOOOftCH Btorch Center 20S74001 COMPANY CONFIDENTIAL TEA 85 Budget: BIOACTIVE RUBBERS $3 0,000; Spent Through February: $6,151; Projected Rate: 106*Y- 856-469 Budget: BIOACTIVE RUBBERS By: C. S. Schollenberger, J. W. Born This project is to extend our knowledge and capabilities in the use of polymers as media for the regulated release of bioactive agents. During the first quarter we received, extracted, and analyzed for residual steroid content a set of cylindrical implants. These were returned after imp)-.r.*ation in cattle by the collaborating drug company. The matrix polymers involved were Estanes 5701 and 5714, Shell ST-125 (block SBR) and PVC plastisol. Initial steroid loading was 100 mg. per implant. Results show the ST-125 to have released the most steroid; the Estanes released less and similar amounts, and the PVC released the least. This is about the order found m Brecksville in vitro extractions, but release in the animals was slower than in saline. The Estane implants showed good biological performance. Performance of the ST-125 and PVC implants was.not as good. Microscopic e.-arrination of stored 100 mg. implants shows steroid bloom on their surfaces. We feel this could be corrected. We are now analysing a group of 55 mg. implants that were implanted in cattle. We have learned how to do these extractions and analyses quite accurately. At the drug company's request, we provided flat impiants of Estane 5714 and ST-125 at two steroid levels for their extraction tests. And. we aro coating such implants with the corresponding matrix polymers for similar tssts. $30,000; Spent Through February: $6,141; Projected Rate: 106% 20674002 B.F.GOOOttCH Reteorth Csntw COMPANY CONFIDENTIAL DISTRIBUTION Research Files - 2 R. J. Fawcett - 2 R. W. Strassburg R. G. Bauman M. R. Frederick C. F. Gibbe D. E. Ley H. J. Dietrick J. M. Kime E. T. McDonel R. A. Krueger J. S. Merger Patent Law Department Akron C. H. Stockman R. V. Yohe R. H. Wilaon THE 8. F. GOODRICH CO. JUt 1 5 1%9 RESEARCH LIBRARY QUARTERLY SUMMARY 20674003 BIOACTIVE RUBBERS TEA SECOND QUARTER 1969 BFG04453 B.F. GOODRICH Research Center COMPANY CONFIDENTIAL TEA 8 5 Budget: BIOACTIVE RUBBERS $30, 000: Spent Thru May: $14, 269: Projected rate. ... 8564-69 Budget: BIOACTIVE RUBBERS By: C. S. Schollenberger. J. W. Born With a major drug company, we are studying the tn vitro and in vivo release of a steroidal hormone from selected matrix polymers. During this quarter we provided the collaborating drug company with additional samples of two matrix polymers loaded with a third level of the hormone. Flat implants were cut from these sheets for tests. We also extracted and analyzed five sets of implants, including cylindrical and flat types, after their in vivo exposure by the drug company. Results show the Estane 5714 release rate to exceed that of the other matrix polymer, thermoplastic block SBR. They also show a concentration-release rate dependency. A research report covering work with cylindrical implants was written. The results of this project have stimulated plans to commercially exploit a product based on our findings. $30, 000; Spent Through May: $14, 269; Projected rate: 118%. 20674004 B F GOODRICH Roirarch COMPANY CONFIDENTIAL DISTRIBUTION ^ Research Files - 2 R. J. Fawcett - 2 R. W. Strassburg R. G. Bauman M. R. Frederick C. F. Gibbs D. E. Ley F. J. Donat G- E. Stueber H. J. Dietrick J. M. Kime E. T. Me Done l J. S. Marger Patent Law Department Akron C. H. Stockman R. V. Yohe R. H. Wil son 56C8 nti OCT 31969 HKMLMUV QUARTERLY SUMMARY BIOACTIVE RUBBERS TEA THIRD QUARTER I960 a. f. ooowmch Ussserck Center COMPANY CONFIDENTIAL THIRD QUARTER SUMMARY 1969 TEA 85 BIOACTIVE RUBBERS Budget: $30,000; Spent Through August: $18,306; Proj-<ti rl Rate- K'r 8564-69 BIOACTIVE RUBBERS By: C. S. Srhollenberger, J. W. Born This project is to extend our knowledge and capabilities ir. the use of polymers as media for the regulated release of bioactive agents. We are studying the in vitro and in vivo re'ease of a steroidal hormone from selected matrix polymers v-ith - major drug company. During this quarter additional sheets for flat implant fabrication were prepared. They consisted of several steroid levels in Estane 5714 matrix polymer. We have begun to determine the solubility parameters of four thermoplastic matrix polymers used in the steroid release study. This should provide a more quantitative relation of polymer structure/polarity with release rate. Budget: $30,000; Spent Through August: $18,306; Projected Rate; 82% e o o i^ s o z DISTRIBUTION C0J4PANY CONFIDENTIAL Rasaarch Filas - 2 R. J. Fawcatt - 2 R. G. Bauman M. R. Fradanck C. F. Gibbs D. S. Lay F. J. Donat G. E. Stoabar H. J. Diatrick J. A. Glass J. M. Kims E. T. McDoosl J. S. Margar Patent Lam Dapartmeat Akron C. H. Stockman R. V. YoK* R. H. Wilson o 1970 mim LIBRARY TA fs QUARTERLY SUMMARY BIOACTIYE RUBBERS TEA FOURTH QUARTER 1969 SfGO4451 B. f. OOOORICM RsMorck Canter 20S74007 COMPANY CONFIDENTIAL FOURTH QUARTER SUMMARY 1969 TEA 085 Budget: BIOACTIVE RUBBERS $30,000; Spent Through November: $24,940, Projected Rate: 89% 8564-69 BIOACTIVE RUBBERS By: C. S. Schollenberger, J. W. Born, K. S. Varga Thia project ia to extend our knowledge and ca pa billtie a in the use of polymer a aa media for the regulated releaae of bioactive agenta. We are atudying the in vitro and in vivo releaae of a stcrciJ hormone from aelected matrix polymara with a major drug company. The work ia expected to lead aoon to the only known commercial parenteral appli cation of a BFG material/product. During thia quarter we worked with IPC Development to provide eighthundred flat implants for critical animal teats by the collaborating drug company. These implants were cut from extruded strips of commercial Estane 5714 and from the stabiliaer-free polymer made in the laboratory for thia project. Eight compounds were mixed representing four levels of steroid ` hormone. Our analyses of the mixes and implants showed that intended levels were achieved. Thia initial attempt to make implants by the proposed production method went smoothly. But the extruded strip and therefore the implants varied a little in sixe. This has not interfered with the animal tests which are now underway. Budget: Effort on this project was curtailed this quarter to match a curtailed badget- $M,000; Spent Through November: $24,940; Projected Rate: 89% 8 0 (J t S 0 2 BFG04458 r* t tottorch C#nt*r