Document 2R20KQn53ZNg9QVgEZQe2rp1a

Valves for the Pharmaceutical and Fine Chemical Industries Table of Contents Page Overview 3 Disc Bottom Outlet Valves Stainless Steel, Hastelloy and other Alloys 4 Glass/PTFE/PFA-lined Body 6 Additional Sensor Options - Temperature Sensors, Lining Integrity Monitoring 9 Ram Bottom Outlet Valves Stainless Steel, Hastelloy and other Alloys 10 Bottom Outlet Valves with Integrated Sampling Systems 11 Process Analytical Technology (PAT) in SchuF Valves 12 Case Study: SchuF MultiProbeTM Valve- Bespoke PAT 15 Case Study: Pharmaceutical Valve with PAT & Filtration Function 16 Customer Enquiry Form 18 Product Portfolio Overview 19 SchuF is fully registered, accredited and certified worldwide 2 Valves for the Pharmaceutical and Fine Chemical Industries Overview In recent years, the dual pressures of rationalisation and safety/environmental regulations have driven technical progress in the pharmaceutical and fine chemical industries, resulting in a number of significant developments. SchuF, which has partnered many of the world's leading pharmaceutical companies in this field, have been at the forefront of these innovations for many years, and continue to investigate new possibilities while refining and improving existing products. The major concerns of manufacturers and processers working with pharmaceutical intermediates and other fine chemicals include: Process Analytical Technology (PAT) Elimination of dead space and cross-contamination issues, in line with GMP compliance Zero leakage to atmosphere, including lethal service requirements Firesafe Certification Absolute positive shut-off, Leakage Rate Class VI Ability to handle media crystallisation and crust formation FDA compliance Clean-In-Place (CIP) capabilities Temperature measurement, even in low volume batches Efficient, safe sampling Internal surfaces polished to Ra < 0.2m Additional sensor functions Each and every SchuF pharmaceutical valve addresses these concerns while demonstrating the industry-leading combination of such time-proven qualities as robust construction and reliable operation. In addition, the customer benefits from SchuF's innovation-friendly approach, which continuously leads to the utilisation of new materials, more efficient operational designs, and an expanding range of multiple-function capabilities. 3 Disc Bottom Outlet Valves - St. St., Hastelloy and other Alloys Features Type 25 SchuF flush-mounted bottom outlet valves see extensive service in the bulk pharmaceutical and fine chemical industries. They are often used in the production of core active-ingredient acids and vitamins. The Type 25 bottom-outlet Valve in Stainless Steel, Hastelloy (or other alloy) body and trim provides a solution where customers require a flush-mounted, custom-fit valve with high corrosion resistance and complete operational reliability in order to maximise their system's high-level functionality. Bespoke design requirements can be incorporated into each valve alongside tried and tested standard design features, such as elimination of dead-space in the vessel outlet, FDA and GMP compliance for disc valves, full cleaning capability together with being flushable in place and fire-safe certified. Additional options include flushing/purging connections, internal and external polishing, positioners, limit switches, solenoid valve(s), `seat-less' disc valve construction, CIP / GMP, manual over-ride actuator, `T'- or spool-piece connection, leak detection, disc-grinding, jacking bolts, disc contouring, tapered seats, live-loaded packing and spindle wipers. Seat- this can be metal, PTFE, or PTFE with metal core (for fire-safe applications) Sealing methodsoft radial seal, or metal-to-metal Temperature Sensor Type 25BSbellows seal to atmosphere Emergency stuffingbox with PTFE sealing rings- secondary seal to atmosphere Sturdy cast yoke Actuator- as per customer specification (pneumatic actuator shown) Packing material Options Quick and easy maintenance Stuffing-box seal to atmosphere (Type 25BS) - shown here with PTFE spindle wiper Stroke/Position Indicator CIP (Clean In Place) optionFlanged connection shown Temperature Sensor Connecting Head Manual override for pneumatic actuator 4 Disc Bottom Outlet Valves - St. St., Hastelloy and other Alloys Standard Dimensions for common valve sizes Dimensions for other sizes available on request. d1 Left: The valve seat is custom-fit to match the vessel bore dimensions. The external diameter of the seat (d1) is one millimetre less than the vessel bore. X The height of the seat (X) will also match the seat and allows for a gasket seal between the seat and the vessel. d1 Hub Stroke h1 aX f1 Left: Standard version b Type 25BS/BH Disc O-Ring Medium Cutaway View Seat Vessel Wall Above: GMP O-ring seal between seat-top and vessel wall d1 a f1 h1 X Hub Stroke b D2 H (PM) H (PS) Above: Low-profile version with side-mounted actuator Valve dimension table for Disc BOV types 25BS/25BH, with PM Size Imperial X Standard d1 Standard a b h1 H (PM) H (PS) Stroke D2 50/40 2"/1" 35 69 70 149 11 687 360 30 315 80/50 3"/2" 35 94 72 147 12 692 365 35 315 60 100/80 4"/3" 35 129 74 209 18 752 425 35 315 150/100 6"/4" 40 179 87 209 18 772 445 35 315 200/150 8"/6" 40 233 103 250 24 879 510 45 390 50/40 2"/1" 35 69 62 173 11 761 434 30 315 80/50 3"/2" 35 94 53 214 12 707 380 35 315 45 100/80 4"/3" 35 129 69 255 18 775 448 35 315 150/100 6"/4" 40 179 68 279 18 798 471 35 315 200/150 8"/6" 40 233 107 321 24 955 586 45 390 All dimensions are in mm unless otherwise stated. Dimensions for other BOV models/actuators are available on request. 5 Bottom Outlet Disc Valve - Glass / PTFE / PFA-lined Body Features SchuF flush-mounted bottom outlet valves see extensive service in the bulk pharmaceutical and fine chemical industries. They are often used in the production of core active-ingredient acids and vitamins. The Type 25 bottom-outlet valve with lining in glass, PTFE/PFA, tantalum, or other materials such as rubber, provides the ideal solution when customers require a flush-mounted, custom fitted valve with high corrosion resistance and complete operational reliability in order to maximise their system's high-level functionality. Bespoke design requirements can be incorporated into each valve alongside tried and tested standard design features, such as elimination of dead-space in the vessel outlet, FDA and GMP compliance, full cleaning capability (Clean In Place, CIP) and fire-safe certification. Valves can be supplied with bellows or stuffing-box seal to atmosphere. Lined body- lining can be glass, PTFE, PFA, or other. Glass shown here Glass Disc Seat- can be PTFE/PFA, with or without a metal core (for fire-safe applications) O-Ring PTFE/PFA-lined body shown here Purge flangeClean-In-Place options Packing ringsPrimary seal to atmosphere PTFE bellows Secondary seal to atmospherepacking materi- al options Stroke/ Position Indicator Type 25 Seat Options: Both valves on this page shown with standard glass disc and standard raised seat Glass Disc Glass-lined spindleother linings available, such as tantalum Sturdy cast yoke Actuator- as per customer specification (pneumatic actuator shown) Temperature Sensor Connecting Head Actuator- as per customer specification (Manual Handwheel shown) 6 Bottom Outlet Disc Valve - Glass / PTFE / PFA-lined Body Features Type 25 Additional options include temperature/PAT sensors, accessories such as positioners, limit switches or solenoid valves, actuator manual over-ride, leak detection and live-loaded packing. Tall glass disc: Nozzle space filled without narrow dead-space Glass-lined spindleother linings available, such as tantalum Flat seat with metal core, lined with PTFE/PFA Glass-lined body shown here Packing ringsprimary seal to atmosphere Stroke/Position Indicator Seat Options: Valve shown with tall disc (allowing easy cleaning) and flat seat Purge flangeClean-In-Place Seat Options: Valve shown mounted to a vessel with a pad flange, with standard glass disc and flat seat Sturdy cast yoke Actuator- as per customer specification (pneumatic actuator shown) Optional Manual Over-ride for pneumatic actuator Temperature Sensor Connecting Head The SchuF Type 25PS Valve shown above is designed specifically for use in areas where restricted installation height is an issue 7 a f1 h1 X Stroke h1 aX f1 Stroke h1 a f1 Bottom Outlet Disc Valve - Glass / PTFE / PFA-lined Body Standard Dimensions for common valve sizes Standard seat and actuator d1 Flat seat with standard actuator* Standard seat with side-mounted actuator d1 Stroke b 60 b 60 D2 45 b H (PS) H (PM) H (PM) D2 D2 Dimensions for other sizes available on request. *Note - Variables `X' and `d1' not applicable for flat-seat valves. Valve dimension table for lined Disc Bottom Outlet Valves, with standard Pneumatic Diaphragm Actuator 60 45 Size Imperial 50/40 2"/1" 80/50 3"/2" 100/80 4"/3" 150/100 6"/4" 200/150 8"/6" 50/40 2"/1" 80/50 3"/2" 100/80 4"/3" X Standard d1 Standard x min-max a b h1 H (PM) H (PS) Stroke D2 50 49 30 - 75 94 160 17 630 475 30 315 52 79 52 - 100 57 167 18 710 480 35 315 66 99 66 - 150 55 180 25 790 480 35 315 81 148 81 - 180 75 200 23 790 500 35 315 min 40 min 190 40 - 180 110 240 42 875 700 45 390 50 49 30 - 75 43 160 17 630 475 30 315 52 79 52 - 100 14 115 18 710 480 35 315 66 99 66 - 150 14 155 25 820 510 35 315 All dimensions are in mm unless otherwise stated. Dimensions for other Bottom Outlet Valve models/actuators are available on request. 150/100 6"/4" 81 148 81 - 180 14 175 23 840 550 35 315 200/150 8"/6" min 40 min 190 40 -180 65 330 42 850 675 45 390 Right: GMP Lip-Seal between seat-top external face and the vessel wall. The lip is pressed outwards by the vessel pressure and provides a seal against the inner wall of the vessel bore. Note: The option of an O-ring seal in this location is also available Disc Lip-Seal Seat Medium Vessel Wall Cutaway View 8 Additional Sensor Options Temperature Sensor Functions SchuF Bottom Outlet Valves can be supplied with temperature measurement capability as a standard option. Retro-fit of existing valves is possible. 2xPT100 RTD, 4-wire, Class 1/3B sensors can be integrated into the disc and spindle to provide continuous real-time temperature measurement of the medium. The sensors are fitted at the medium's lowest point. No additional vessel nozzles are required. In many cases the sensor can be removed for calibration without removing the valve from service. Transmitters and connection heads supplied according to customer requirements The sensor cables can be routed out through the side of the valve in the yoke area, or through the actuator at the base of the valve. In either case, a connecting head with transmitter can be supplied at this point. The disc can be supplied with a tower to further increase accuracy and reaction time of the temperature measurement. With glass-lined discs, a tower can be supplied in tantalum. Glass Disc with integral Temperature Sensor Glass Disc with Temperature Sensor underneath a tantalum cap Lining Integrity Monitoring The integrity of the glass lining of a reactor vessel is of crucial importance and it is vital that any damage to the lining is discovered and evaluated as quickly and accurately as possible. Schuf supplies glass discs which have such monitoring capability via two electrodes on the top surface of the disc. Please contact us for more information on this feature. Metal disc with integral Temperature Sensor in extended tower 9 Ram Bottom Outlet Valve - St. St., Hastelloy and other Alloys Features Type 28 SchuF ram valves have seen extensive service in the bulk pharmaceutical and fine chemical industries, handling both liquid and powder media. They are often used in the production of core active-ingredient acids and vitamins. The Type 28 Bottom outlet valve with Stainless Steel, Hastelloy (or other alloy) body and trim (PFA lining is also possible) provides a solution where customers require a flush-mounted, custom-fit valve with high corrosion resistance and complete operational reliability in order to maximise their system's high-level functionality. Bespoke design requirements can be incorporated into each valve alongside tried and tested standard design features, such as full-stroke open flow, elimination of dead-space in the vessel outlet, GMP compliance for ram valves, full cleaning capability together with being flushable in place and fire-safe certified. Additional options include flushing/purging connections, internal and external polishing, positioners, limit switches, solenoid valve(s), manual over-ride for powered actuators, `T'- or spool-piece connection, leak detection, jacking bolts, ram contouring, tapered seats, and live-loaded packing. Seat- this provides a range of sealing options, e.g. soft radial seal or metal-to-metal sealing. In addition, the sealing point can be in the valve itself or higher in the vessel bore Live-loaded packing option Sturdy cast yoke Temperature Sensor SchuF ram valves provide full flow when the ram is completely retracted. Radial sealing ring arrangement shown here Packing material options The SchuF ram valve seat is custom-fitted to match the vessel flange dimensions. The seat `d1` diameter is 1mm less than the vessel bore, and the seat height `X' matches the bore height. Stroke/ Position Indicator Radial seal in valve body d1 X Temperature Sensor Connecting Head Radial seal in vessel bore d1 X Actuator- as per customer specification Radial seal in valve body, seat with custom d1 d1 X 10 Bottom Outlet Valves - Draining and Sampling Systems Multiple Benefits SchuF offers a number of draining and sampling systems which operate through a single valve connection point. For example, Schuf supplies a combination of a ram-type drain valve with an integrated laterally mounted wafer-type sampling valve, Type 28PF. Type 28 & 30 Series Advantages of this system include: No need for an extra, dedicated vessel port for sampling Unused sample is simply returned into the vessel - no waste Crust-breaking facility available Gravity feed, no need for vacuum or Nitrogen No submerged piping which can become blocked Large sample diameters for crystals Sample volume control with dead-man's handle Exact amounts trapped in sample cavity An additional flush-valve prevents cross-contamination If space is at a premium, it is possible to combine wafer-type sampling valve with a disc valve in a patented SchuF combination, the Type 25PF. This valve is a shorter, more compact, lower-cost version which still features the sampling and crust-breaking capability. Above: The type 28PF sampling system allows a variety of operational steps to be carried out in any sequence, with repetitions as required- for example, multiple sample-taking before valve is opened and product released to the next stage Right: Large type 28 Ram valve with integral sampling function and pneumatic actuation Right: Small type 28 Ram valve with integral sampling function and pneumatic actuation Above: Sampling Valve with repeatable fixed-volume sampling capability, with heating (or cooling) chamber and purge 11 Process Analytical Technology SchuF Patented MultiProbeTM Valve for PAT Applications Type 25X PAT Applications in Pharmaceutical Reactors In recent years, there has been a significant increase in the use of Process Analytical Technology to optimise pharmaceutical and fine chemical manufacturing processes. Chemical processes can be monitored with fully-immersed PAT tools such as infra-red (IR), Raman, FBRM, and PVM probes, where direct insertion into a reactor vessel is required. Reactions can be analyzed in real time with PAT tools, providing immediate data on critical process control parameters (such as reaction initiation/endpoint, reaction progression, intermediate formation, concentration, yield, etc.). If problems arise during the reaction, parameters can be modified before the batch is completed. The aim is therefore to reduce production cycling time and eliminate product sampling, prevent rejection of batches and to improve energy, material use and overall efficiency. Challenges facing the Customer A major challenge in the use of PAT is the lack of suitable entry points to introduce the measuring technology into reactors. The modification of existing vessels is prohibitively expensive, requires revalidation and is sometimes not even permitted. Entry from the reactor top can also be a problem for low volume batches. SchuF has developed a patented, innovative, cost-effective solution to overcome this problem. The SchuF PAT Solution-MultiProbeTM Reactor Bottom Outlet Valve (Patented): SchuF has long been the market leader in drain valves for pharmaceutical and fine chemical applications, leading the way with deadspace-free, GMP-compatible designs, bellows sealing to atmosphere and fire-safe certified valves. Now SchuF enables customers to incorporate PAT technology into a reactor bottom outlet valve with builtin PAT probe monitoring capabilities. The PAT probe is installed through the valve actuator, stem and disc and is directly exposed to the medium in the reactor. 12 Process Analytical Technology SchuF Patented MultiProbeTM Valve for PAT Applications Type 25X Technical Features: SchuF's unique MultiProbeTM patented design ensures that the medium in the reactor does not leak through the valve stem. The PAT probe can be removed quickly between batches without the need to remove the valve from the vessel. As the PAT probe is located in the bottom part of the vessel, even low volume batches can be monitored in real-time. Integrating PAT technology with the SchuF valve eliminates the need to modify existing reactor vessels. It is a low-cost solution, allowing the implementation of modern PAT technology in both existing and new reactors. A wide range of materials is available, including Stainless Steel, Hastelloy, Glass-Lined, PTFE-Lined and Tantalum Clad valves. The MultiProbeTM Valve - an extremely cost-effective solution: No need to modify reactor vessels Reduced batch cycle time/product sampling Improved product quality Improved energy and material use Increased process robustness Easy installation and maintenance The single-shaft version accommodates one PAT probe. The Infra-Red PAT probe shown here incorporates a 1xPT100 temperature sensor The dual-probe version utilises two shafts, one for a PAT probe and one for a standard 2xPT100 temperature sensoreach instrument can be installed or removed independently of the other 13 Process Analytical Technology SchuF Patented MultiProbeTM Valve for PAT Applications The following PAT Probe types have previously been utilised in SchuF Valves: FTIR (mid- and near-IR ranges) RAMAN Turbidity ATR LiquiSonic pH Right: A SchuF disc-rising drain valve with singleshaft PAT probe arrangement. The valve has a glass-lined body and PTFE-lined seat, together with a side-access flange which provides CIP functionality Type 25X Above: A SchuF disc-rising drain valve with double-shaft PAT probe and temperature sensor arrangement. Further Sensor Technology LiquiSonic from SensoTech: Measure absolute sonic velocity in the process liquid Detect & monitor liquid concentration and density Probe is open to the process (full immersion) Integral part of the valve disc 14 Process Analytical Technology Case Study: SchuF MultiProbeTM Valve- Bespoke PAT Type 25X Pfizer UK outline how PAT technology can be introduced- even with limited reactor entry points Staff at Pfizer R&D had introduced online mid-infrared (IR) spectroscopy in the research laboratories as an important tool for understanding and optimising processes on a small scale before upscaling to commercial manufacturing processes. There are significant challenges facing the transition of this technology from the laboratory to larger-scale manufacturing, and perhaps the most significant challenge arises because of the general lack of suitable entry points for the measurement technology into the reactor vessels and the prohibitively high cost of modifying or replacing the reactors in a facility to enable PAT to be used throughout. Bespoke PAT To overcome this problem, Pfizer UK utilised a bespoke drain valve configuration with built-in online IR monitoring capability. Figure 1 (below, right) shows the schematic of the drain-valve with integrated IR probe. In this design, an oversized actuator and valve bellows were used to accommodate the extra diameter required for an IR probe. In use, the IR probe protrudes through the valve plug, adjacent to a temperature probe, and performs measurements in the body of the liquid held in a reactor. A specialised two-seal design enables the IR-probe to be retracted for replacement or repair if required. This overall design also provides another layer of flexibility because the probe is a stand-alone unit and can be connected to an online mid-IR instrument or transferred to the laboratory and used with a lab-based instrument. These Hastelloy valves have been designed with two types of bespoke reactor seal, so that they can be used on both Hastelloy and glass-lined reactors of various sizes, eliminating the risk of damaging the glass-lined reactor neck. Low-cost solution This relatively low-cost solution has enabled PAT technology to be applied across 22 reactors in the facility without the need to modify any of the equipment - a significant improvement from the three reactors that previously had ports suitable for the IR probes. Although it was previously possible to install an IR probe via a recirculation loop incorporating an IR flow-cell, this arrangement has a number of safety concerns. These include hazards associated with reactive chemistries in flexible hoses: difficulty in recirculation of heavy slurries: and also, this setup is not suitable for temperature- sensitive chemistry. Further advantages offered by the new approach include the fact that we can generate PAT data even at the minimum working volume in a reactor; we are able to monitor cryogenic and high-temperature reactions, and, if required, correct the spectral data for the effect of changing reactor content temperature. Therefore this relatively simple but innovative valve installation has the potential to significantly impact the business through reduced batch cycle time, improved quality and increased process robustness. The Chemical Engineer Today/ May Ling Yeow/Pfizer UK Pic: Pfizer UK Figure 1 15  Robert Gerhardt | Dreamstime.com Lucaderoma | Dreamstime.com Process Analytical Technology Case Study: Pharmaceutical valve with PAT & Filtration Function SchuF valves are tailor-made to match the customer's precise requirements. As well as operating in its primary function, a SchuF valve can provide additional PAT functionality in a number of areas. There follows is an example of a valve which was designed with such multifunctionality in mind. The Roche Group is a leading international healthcare company with principal businesses in pharmaceuticals and diagnostics. The Process Issue SchuF have been able to provide a technical solution to a difficult process which had previously been an issue for Roche. The core activity of this Roche process is one of particle engineering. The product crystallises in the medium as temperature is reduced, and here real-time measurement of the reaction is crucial to the success of the entire process. In addition, extremely fine adjustment of the flow rate from the vessel is required. Roche Ireland, based in Clarecastle, Co Clare, is a manufacturing centre of excellence for the production of active pharmaceutical ingredients destined for conversion to medicines in dosage form at other Roche facilities throughout the world. 16 Process Analytical Technology Case Study: Pharmaceutical Valve with PAT & Filtration Function The Solution Initially, the valve keeps the vessel 100% closed when the process is initiated. The valve provides parallel PAT and temperature-sensing functions. In this particular process, the temperature of the reactor is being reduced to bring about crystallisation of the product. Thus the temperature is continuously monitored while the PAT probe is used to measure turbidity, which will indicate when the optimum conditions for crystallisation have been reached. At this point in the reaction, the valve can be opened with an incredibly fine degree of precision due to the pneumatically-operated actuator. This fine control, in conjunction with the integral filter/strainer with its graduated level of particulate straining, allows the carefully-controlled releasing of the solvent liquors. This finely-adjusted flow rate allows the crystallising product to physically support itself in the reactor, allowing the solvent to drain through while creating the opportunity for the desired larger-sized crystals to form as the de- liquoring process continues. Dr. John O'Reilly explained that a normal valve would not have been acceptable for their needs. He goes on: "The resulting design is one which provides a solution which could otherwise only have been achieved by potentially spending millions on a full Hastelloy separation system". The conventional process, which would include a set of reactors and separators, plus the transferring of material between processes (the reaction would take place in one vessel, crystallisation in another) and the various cleaning and preparation steps, could require a number of days to reach completion. Utilising the SchuF valve allows the operation to be done in 30 minutes, with minimal effort and increased control. SchuF, in conjunction with Senior Analytical Chemist Dr. John O' Reilly and Roche technical staff, was able to provide a Drain Valve which incorporated a number of crucial capabilities. 17 Customer Enquiry Sheet Part 1 - Your Company Information Name: Company: E-mail: Part 2 - Your Order Information General: Quantity: Tag No.: Valve Model: Part 3 - Valve and Process Information Valve Information: Valve Inlet Size (DN/Inch): Valve Outlet Size (DN/Inch): Inlet Flanged/Weld-End: Operating Temp.: Design Temp.: Body Material: Medium: Certificates Etc.: Actuator Type: Air-Fail Position: Part 4 - Further Notes/Topics/Info Name: Company: E-mail: Name: Company: E-mail: Title: Telephone: Fax: Application: Project Name: Project No.: Valve Pressure Rating: Valve Delta P: Outlet Flanged/Weld-End: Operating Pressure: Design Pressure: Trim Material: Fugitive Emissions/Clean Air: Firesafe Rating: Air Supply Pressure: Manual Override: Title: Telephone: Fax: Title: Telephone: Fax: 18 Product Portfolio Overview The SchuF Group has delivered over one million valves during its 100 year history to a wide variety of industries in over 50 countries worldwide. Headquartered near Frankfurt in Germany, the company has additional design and manufacturing centres in Italy, India, Ireland, UK and the USA. The SchuF Group has sales and agent offices covering almost every country in the world. We manufacture valve products that control, isolate, divert, and sample liquids, gases, powders, and slurries. Our product range of engineered, customised valves includes: Drain & Sampling Valves Piston Bottom Outlet Valves Disc Lowering / Rising Bottom Outlet Valves Custom Bottom Outlet Valves Screw-in, Line & Wafer Sampling Valves Isolation Valves Control Valves Switching Valves Lift Plug Valves TruEPlug Valve Globe Valves High Pressure Angle Valve Special Gate Valves Angle Control Valves Multistage Control Valves Cage Control Valves In-line Control Valves Automatic Recirculation Valves Y, R & T type Diverter Valves Multiway Diverter Valves SwitchPlug Valve ManiFlow Selector Valve Custom Diverter Valves Spray Rinse & Injection Valves Spray Rinse Valve Steam Injection Valve Safety Related Valves Line Blind Systems Changeover Valves Emergency Tank Shut-off Valves (TESO) Customised Valves Pharma Valves Client List: Abbott AbbVie Amgen Astellas Pharma AstraZeneca BASF Bayer BMS Boehringer Ingelheim Bristol-Myers Squibb CAD Middle East Dow Chemical DSM Eisai Co Eli Lilly GE Healthcare GlaxoSmithKline Hospira Janssen Johnson and Johnson Lonza Merck Monsanto Novartis Pfizer Roche Sanofi Scinopharm Shasun Syngenta Takeda UCB SCHUF PHARMA VALVES - 100 YEARS OF INNOVATION 19 SchuFli! Worldwide 4440-,*14ill. 4 UNITED KINGDOM GERMANY www.schuf.com 61'.t Fetterolf Corporation phone: @fetterolfvalves.corn SchuF (USA) Inc. phone: @schuf.us z< SchuF Valve Technolo _I phone: LU Mschuf.ie GmbH www.schuf.de SchuF Chemieventile Vertriebs GmbH & Co.KG phone: (4?schuf.de Your Sales Channel: SchuF Benelux B.V. phone +31 25 12 34 448 Mgschuf.nl Emartins Armaturen -- ME phone: +55 19 98013503 Lschuf.corn SchuF South East Asia Pte. Ltd. phone +31 62062 6664 M@schuf.n1 SchuF Valves China Ltd. phone +85 22 86 50 86 1 Egvol.net Your Local Agent: --I La Tecnovalvo S.r.l. < phone: +39 023503508 Wlatecnovalvo.com SchuF (UK) Ltd. phone: @schuf.co.uk I-1 SchuF Speciality Valves India Pvt. Ltd. Z phone: M@schuf-india.com