Document 2NoeqzxGvVE92Mb5Ykyak7zdL

TO: W. C. HOLBROOK FROM: R. IC. HINDFRIER SUBJ: AUGUST 1981 PROGRESS y i U\xlDATE: AUGUST 31, 1931 1. PVC/CPVC Pipe. Task Force. A steering committee (V/. C. Becker, R. A. Krueger, K. Lee, M. M. O'Hara) for this task force has been formed. 1 have, assisted L. Filer in developing a detailed proposal of objectives and activities for this task force. 2. IISRP. EFG has terminated its membership in IISRP. After a discussion with K. Creene, I contacted IISRP to determine whether they would be receptive to my continued participation in selected areas. A response is expected shortly. 3. Cure-Rite 18 and OBTS. The long-term feeding studies with Cure-Rite 18 and Santocure MQR (.OBTS) con tinue to proceed satisfactorily. 4. Surpori. We have initiated human patch testing with a Surpon abscrbant polymer. Results are expected by the end of September. A test marketing program is planned if the results are favorable. We have received a verbal report that Surpon extracts caused significant cell death in the cytotoxicity screen. This indicates that we will have to consider further studies to look at the effect of Surpon polymers on sensitive tissues. However, other verbal reports from one of our customers indicate that Surpon A-3S3 did not produce any detrimental effects in wound healing studies. 5. Combustion Toxicology. Combustion toxicology studies with certain PVC, estane, and CPVC products are due to begin soon. 6. International/Europe. We are continuing to work with International to develop a transition program to cope with unfinished projects that are affected by the sale of Ciago. 7. International/Australia. We are continuing to work with Altona in an effort to obtain health related information for Australian food and drug approval of Bisp'nenol A. 2I13Z001 BFG10700 ,\m o l io>p * Harm, uoi, >o. i.to- i <* Interactions between Drugs and Polyvinyl Chloride Infusion Bags Elizabelh A. Kowaluk, Michael S. Roberts, Harvey D. Blackburn, and Alan E. Polack Forty-six injectable drug products, many of which are admin istered by i.v. infusion, were studied for loss from aqueous solu tions stored in polyvinyl chloride infusion bags for various peri ods of time. The polyvinyl hags were stored in the dark ut room tempera ture for up to three months. Drugs stored in glass vials served as controls. The solutions were assayed spectrophotometrically at regular intervals. The effects of drug concentration and pH on the loss of drug from solution were studied. Octanol-water par tition coefficients were used as a gauge of lipid solubility of the drugs. Five of the drug products--clomethiazole edisylate, diaze pam, hydralazine hydrochloride, thiopental sodium, and war farin sodium--were found to be lost to a substantial extent after one week. For all drugs studied, the effect of the initial concen tration on drug loss varied. The amount of drug lost over a given t ime was a function of the pH of the solution. The main physico chemical determinants controlling drug sorption appeared to be the extent of ionization and the lipid solubility of the drug. For most of the drugs studied, minimal losses from the aque- ous solutions were observed over short periods of storage time. Disappearance was slow and time dependent, indicating a diffu- ' *. s sion-controlled sorption process. The losses of clomethiazole edisylate, thiopental sodium, and diazepam may be clinically important. Index terms: Absorption; Anesthetics; Anticoagulants; Clo methiazole edisylate; Concentration; Containers; Diazepam; Diffusion; Hydralazine hydrochloride; Hydrogen ion concentra tion; Hypotensive agents; Injections; Ionization; Plastics; Poly vinyl chloride; Sedatives and hypnotics; Solubility; Stability; Storage; Thiopental sodium; Warfarin sodium Previous studies1-6 have reported the loss of certain drugs from aqueous solutions stored in plastic infusion bags for various periods of time. Generally, these losses have been attributed to interaction between the drug and the plastic infusion bag. Such interaction may result in reduced drug delivery to the patient and, in some cases, diminished ther apeutic response. Documentation of the compatibility of substances cur rently administered by intravenous administration sets, with the plastic infusion bags used in certain systems, is lim ited.l-3-5-7 The most detailed evaluation of drug sorption by plastic infusion bags is in the study of Moorhatch and Elizabeth A. Kowaluk, Michael S. Roberts, Ph.D., Harvey D. Blackburn, M .S, and Alan E. Polack, Ph.D., are associated with the School of Pharmacy, University of Tasmania. Address reprint requests to Ms Kowaluk, School of Pharmacy, University of Tasmania, Box 252C, GPO, Hobart, 7001, Tasmania, Australia. The donations of Travenol Laboratories and other pharmaceutical man- ufacturers in Australia are acknowledged. The assistance of the hospital pharmacy departments of Flinders Medical Center in Adelaide, Royal Hobart Hospital in Hobart, and'Alfred Hospital in Melbourne, is acknowledged. Supported by a grant from the National Health and Medical Reaearch Council, Australia. -- Presented at the Pharmaceutical Sciences Section of the Australian and New Zealand Association for the Advancement of Science meeting, Adelaide, May 1980. Copyright 1981, American Society of Hospital Pharmacists, Inc. All rights reserved. Chiou,4 which reported on the sorption of 17 drugs. Although only limited information is available on the compatibility of drugs with polyvinyl chloride (the main resin in com mercially available plastic infusion bags), the sorption of drugs by nylon and polyethylene has been evaluated ex tensively.8-12 As the availability of medication through the intravenous route is of critical importance in patient therapy, it is essential to know not only which substances may be lost during intravenous infusion, but also which drugs may be safely administered using plastic intravenous delivery sys tems. The present study was undertaken with the following intentions: 5 1. To survey a range of drugs, including those presently being administered by intravenous infusion, for possible inter actions with plastic infusion bags, 2. To establish some of the physicochemical variables that control the rate, extent, and mechanism of such interactions to enable the subsequent development of criteria that may be used to predict their occurrence, and 3. To assess the possible clinical implications, if any, of those interactions that were found to occur. Ji; The study consisted of several parts, the first being a . preliminary survey of a range of drugs to identify the drugs k that are lost from aqueous solution during storage in plastic \ infusion bags. The main goal of the survey was to evaluate ^ the compatibility of medicaments routinely used in infusions '<;!; by various Australian hospitals. The compatibility of anti- V neoplastic medications with plastic infusion bags was not v examined in this survey because of their restricted avail ability and cost. In the second part of the study, the relative losses of some - selected drugs in unbuffered aqueous solutions were com pared with the losses in solutions buffered at pH 7.4. This study was undertaken because in situ pharmacologic studies are usually performed with drug solutions maintained at a pH of 7.4.13 Methods Table 1 lists the drug products used in the preliminary survey. The drugs norepinephrine bitartrate* and isopro terenol hydrochlorideb were examined; however, they were found to be unstable on storage and were not considered further. Studies of the loss of all but two of the drugs from aqueous solution during storage in plastic infusion bags were con ducted using 0.9% sodium chloride injection as the solvent. The study of the loss of sodium nitroprusside was performed with 5% dextrose injection as the solvent, and the study with clomethiazole edisylate used the infusion solution supplied by the manufacturer. The preliminary survey was conducted using Viaflex (polyvinyl chloride) infusion bags' containing 500 ml of 0.99! sodium chloride injection or 500 ml of 5% dextrose injection in the case of sodium nitroprusside. Each drug was prepared in an appropriate concentrator so that when a practical volume (50 ml or less) was injectec *0 Go W Oo 130S American Journal ol Hospital Pharmacy Vol 38 Sap 1981 BFG10702 0002-9289/61/0901-1308S01.50 1 Drugs sod polyvinyl chloride infusion b9S drug was determined (Table 1). Blank solutions containing all components except the drug were used for adjustment of zero absorbance. In all cases, the drug solutions followed Beer's law over the concentration range studied. Samples of the following drug solutions were diluted immediately before assay: (1) acetazolamide sodium solutions were di luted 1:1 with phosphate buffer pH 8.1; (2) ampicillin tri hydrate solutions were diluted 1:1 with phosphate buffer pH 7.4; (3) amoxicillin trihydrate and metronidazole solutions were diluted 1:1 with 0.2 N hydrochloric acid; (4) diazepam and dopamine hydrochloride solutions were diluted 1:1 with 0.2 N sulfuric acid; and (5) clomethiazole edisylate solutions were diluted 1:200 with distilled water. The aminoglycoside antibiotics, gentamicin sulfate, ka- namycin sulfate, and tobramycin sulfate, were assayed using the chemical derivatization procedure of Csiba.14-15 This procedure involved the preparation of the dihydrolutidine derivative of the aminoglycoside and its subsequent spec- trophotometric determination. In this study absorbance was measured at 336 nm rather than at 356 nm as suggested by Csiba.15 Samples of all other drug solutions were assayed undi luted. ' , The difference, if any, between the amount of drug in so lution in the Viaflex bag and the amount in solution in the glass vial at any specific time was taken to be the amount of drug lost from solution during storage in the plastic infusion bag. Each result reported is the mean of the assays of at least two containers. The coefficient of variation for the assays was less than 10%. Effect of pH on Loss. The effect of the pH of the drug solution in the plastic infusion bag on loss of drug from so lution was studied for a number of selected drugs by buf fering the solutions to a pH of 7.4 with a final phosphate buffer concentration of 0.02 M. The experimental procedure was the same as the one used for the preliminary survey except that 50 ml of 0.9% sodium chloride injection from the Viaflex bags and 10 ml of 0.9% sodium chloride injection from the glass vials were replaced by an equivalent volume of a concentrated solution of the phosphate buffer (0.2 M). The initial concentrations were the same as in the preliminary survey. Effect of Initial Concentration on Loss. The effect of varying the initial concentration of a drug solution on the loss of the drug was studied for a selection of drugs that showed losses of greater than 10% either from solutions buffered to pH 7.4 or from unbuffered solutions after storage for one week in plastic infusion bags. These drugs were clomethiazole edisylate, hydralazine hydrochloride, thiopental sodium, and warfarin sodium in unbuffered solutions and chlorpromazine hydrochloride, promazine hydrochloride, and promethazine hydrochloride in buffered solutions. -- Octanol-Water Partition Coefficients. Literature values for octanol-water partition coefficients have been used for all drugs studied where possible. When these values were not available for given compounds, partition coefficients were determined experimentally as follows. An aliquot of each drug solution was added to an aliquot of n-octanol1' (ana lytical grade), which had been saturated with the particular diluent being used, in a glass bottle. (The proportions of aqueous phase to octanol phase were varied from 1:1 to 250:1 according to the affinity of a given drug for octanol.) Each bottle was sealed and agitated periodically during its storage in the dark at room temperature. Two aliquots of the drug solution were also placed into separate 50-ml gla3s bottles to act as controls. The aqueous phase was analyzed at weekly intervals until equilibrium was achieved. To prepare the solutions for assay, the content of the sample bottles was centrifuged at 3000 rpm for 10 minutes to achieve as com plete as possible separation of aqueous and octanol phases. The octanol was aspirated off together with about 1 ml of the aqueous phase. The remainder of the aqueous phase was assayed spectrophotometrically (Table 1) and compared with the absorbance of the drug solutions from the control bottles. The apparent octanol-water partition coefficients were determined for each drug according to the following equa tion: K = [(Awi -- Awp)/Awp] (V,,/Vo) (1) where K is the apparent octanol-water partition coefficient, Awi the initial absorbance of the aqueous drug so lution, Awf is the the final absorbance of the aqueous drug solution, Vw is the volume of the aqueous phase, and Vo is the volume of the octanol phase. The apparent octanol-water partition coefficients for all of' the drugs were adjusted for the pH of the. individual infusion solutions using the following equation: Pinfu* ~ Pcorr (1 OCinfiu) = ^ipp (1 0^nfu3)/( 1 <?app) (2) where Pj,,fu is the apparent octanol-water partition coeffi cient for a drug in a given infusion solution, Pcorr is the true octanol-water partition coefficient (i.e., octanol-water par tition coefficient of the unionized drug), Papp is the experi mentally determined octanol-water partition coefficient, and rrinfus end aapp are the degree of ionization of drug in the infusion solution and aqueous solution used for partition coefficient determination, respectively. Results and Discussion Preliminary Survey. Only five of the 46 drug products examined showed substantial loss after storage in plastic infusion bags for one week--clomethiazole edisylate, di azepam, hydralazine hydrochloride, thiopental sodium, and warfarin sodium (Table 1). Except for the phenothiazines, quinine sulfate, quinidine sulfate, and prednisolone, all drugs showing negligible loss from solution, had apparent octa nol-water partition coefficients less than 5. The majority of drugs appeared to be relatively stable in aqueous solutions stored in glass containers. After one week of storage, only methicillin sodium and cephalothin sodium showed any change in absorbance. In both cases an increase in absorbance was observed. 1310 American Journal of Hospital Pharmacy Vol 38 Sep 1981 BFG10704 Orugs and polyvinyl chlofida InlutJoo bags centration (Figure.4). During storage, the bags containing clomethiazoie edisylate solutions seemed to become softer and more pliable, particularly at the higher concentrations. The distinctive odor of the solution was detectable in the immediate vicinity of the bags. It was apparent that clomethiazole edisylate altered the properties of the plastic and that this effect was a function of its concentration. Autian8 reported a similar effect for the sorption of phenol by nylon and for the interaction of certain types of esters with rigid polyvinyl chloride bottles. He suggested that this occurred as a result of the tendency of these substances to act as sol vents for the plastics,8 in some instances causing greater polymer-chain flexibility through plasticization.12 It is probable that clomethiazoie acts in a similar manner. At high concentrations it "plasticizes" or "swells" the polyvinyl chloride resin of the infusion bag. In this way, it enhances its own sorption and possibly its permeation through the plastic also. Fluck9 and Roberts et al.10 reported altered sorption and permeability characteristics for plastics in contact with some organic solvents, as well. pH and Partition Coefficient. Figures 5 and 6 show plots of the percentage of thiopental sodium and promethazine hydrochloride, respectively, remaining in unbuffered and buffered (pH 7.4) aqueous solutions stored in plastic infusion bags for various periods of time. For the acidic drug thio pental sodium, sorption was fastest when the solution was unbuffered (pH 6.0) (Figure 5). At this pH, a greater pro portion of the drug was unionized than at a pH of 7.4. In contrast, sorption of the basic drug promethazine was much greater at a pH of 7.4 when 1.96% of the drug was unionized, rather than at a pH of 5 when only 0.008% of the drug was present as the unionized form (Figure 6). Table 2 shows that the percentage of other drugs lost from aqueous solutions stored in plastic infusion bags for one week was also a function of the solution pH. For a given drug, the extent of loss appeared to be directly related to the fraction unionized. In accordance with the classical pH-partition hypothesis, the greatest loss occurred for the drugs with the highest apparent octanol-water partition coefficients (Table 2). The correlation between percentage of drug lost during ' the storage of aqueous solutions in plastic infusion bags for. one week and the apparent octanol-water partition coeffi cient (PBpp) (Table 2) was poor (r = 0.645, n = 23). There fore, equation 3, which describes that relationship, was of limited value in predicting the probable losses of other drugs. percentage loss = 0.005 Ppp + 20.3 (3) The poor correlation between the percentage loss and the apparent octanol-water partition coefficient can be partly ascribed to the inability of equation 3 to encompass the dy namic nature of the sorption process. For example, drugs with a high apparent octanol-water partition coefficient and a low percentage unionized (less than 0.1%) show a lower percent loss than predicted by equation 1; for those the percentage loss is governed by the rate of sorption of un ionized drug. . Since the pH values of various infusion solutions available for clinical use vary,16 it is possible to minimize the sorption of some lipophilic drugs by plastic infusion bags over short storage times by using infusion solutions with a pH such that the drugs are almost completely ionized in solution. Alter natively, a different i.v. delivery system1 or storage in a re frigerator17 could be used to minimize loss. Consideration of the pH of the solution in studies on drug-plastic interac tion should be applied in clinical situations. The extent of loss of drugs stored in plastic infusion bags may be enhanced by a reduction of the solution volume5 or chemical instability.12-18 These effects should be considered also in the use and storage of solutions in plastic infusion bags. Conclusion For most of the drugs studied, minimal losses of the drug from its aqueous solutions stored in plastic infusion bags over short time periods were observed. However, losses of clo- Figure 5. Effect of pH of infusion solution on percentage of thiopental sodium remaining in aqueous solution during storage in plastic infusion bags: () buffered pH 7.4, () unbuffered pH c* 6.0. Figure 6. Effect of pH of infusion solution on percentage of promethazine hydrochloride remaining in aqueous solution during storage in plastic infusion bags: () buffered pH 7.4, () unbuffered pH ** 5.0. 1312 American Journal of Hospital Pharmacy Vol 36 Sap 1981 BFG10706 Drugs and polyvinyl chlortdo Infusion bsgs/Calocholsmlnos and torbulallna sullalo 36:173-7. 18. Newton DW. Physicochemical determinants of incompatibility and instability in injectable drug solutions and admixtures. Am JHospPharm. 1978;35:1213-22. 19. Hansch C, Leo A. Substituent constants for correlation analysis in chemistry and biology. New York: John Wiley & Sons, 1979. 20. Kurz H, Michels H, Stickel HH. Differences in the binding of drugs to plasma proteins from newborn and adult man II. Ear J Clin Pharmacol. 1977; 11:469-72. 21. Julkunen RJK. The absorption of warfarin from the rat small intestine in-situ. J Pharm Pharmacol. 1976; 28:493-7. Am J Ho*p Pharm. 1981; 38:1314-9 Stability of Five Catecholamines and Terbutaline Sulfate in 5% Dextrose Injection in the Absence and Presence of Aminophylline David W. Newton, Esther Yin Yee Fung, and David A. Williams The stability of dopamine hydrochloride, epinephrine hydro chloride, isoproterenol hydrochloride, methyldopate hydro chloride, norepinephrine bitartrate, and terbutaline sulfate in 5?o dextrose injection with and without aminophylline was eval uated. Kinetic data were obtained from the stability-indicating, -. , high-performance liquid chromatographic assay method for autoxidation of the five sympathomimetic catecholamines and terbutaline sulfate. The autoxidation of epinephrine hydrochloride, isoprotere nol hydrochloride, norepinephrine bitartrate, and terbutaline sulfate was much faster in the alkaline solutions (pH 7.7-8.1) containing aminophylline than in the acidic solutions (pH 3.94.5) without aminophylline. On a molar basis among & agon ists, terbutaline sulfate was considerably more stable than epi nephrine hydrochloride or isoproterenol hydrochloride. The au toxidation of terbutaline sulfate and the five catecholamine* followed apparent zero-order kinetics. The rate constants and degradation time* to fall to 90% of original potency were deter mined for each drug. Visual inspection was found to be grossly inadequate for estimating the stability of catecholamines to au toxidation. Epinephrine hydrochloride, norepinephrine bitartrate, and isoproterenol hydrochloride should not be combined with ami nophylline or similarly alkaline drugs in LVP solutions. The stability of very potent and life-saving drugs prepared for i.v. admixtures must be studied with stability-indicating assay methods. Index terms: Additives; Aminophylline; Bronchodilators; Dex trose; Dopamine hydrochloride; Epinephrine hydrochloride; Hydrogen ion concentration; Incompatibilities; Injections; Iso proterenol hydrochloride; Kinetics; Methyldopata hydrochlo ride; Norepinephrine hydrochloride; Rate constants; Spasmoly tics; Stability; Sympathomimetic agents; Terbutaline sulfate David W. Newton, Ph.D., is Associate Professor, Department of Pharma ceutics. College of Pharmacy, The University of Nebraska Medical Center. Esther Yin Yee Kung, MS, is a pharmacist. Tiers Drug Store, Uxbridge, Ontario, Canada. David A. Williams, Ph.D, is Associate Professor, De partment of Chemistry, Massachusetts College of Pharmacy and Allied Health Sciences, Boston. Address reprint request* to Lr. Newton, Department of Pharmaceutics, The University of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, NE 68105. __ Donations of drug samples by American Critical Care, Ciba Pharmaceutical, Merck Sharp & Dohme, and Sterling-Winthrop are acknowledged. The as sistance of Donna Earnshaw is acknowledged. Abstracted in part from a thesis submitted to the graduate school, Mas sachusetts College of Pharmacy and Allied Health Sciences, in partial ful fillment of the requirements for the M.S. degree. Copyright 1981, American Society of Hospital Pharmacist*, Inc. All rights reserved. The autoxidation" of phenolic drugs, catecholamines, and related sympathomimetics is a common stability problem.1-6 Several of these life-saving drugs, particularly the /32 agonists epinephrine hydrochloride and isoproterenol hydrochloride, may be administered concurrently by in travenous infusion, possibly in i.v. admixtures, with ami nophylline in clinical exigencies such as status asthmaticus and anaphylaxis.7-10 The pharmacologic efficacy of these drugs is directly related to the stability of their phenolic hydroxy (Ar--OH)b groups.4-11-12 An alkaline pH, such as that of aminophylline injection (8.6-9.0),13 is a major de terminant of the autoxidation of Ar--OH to form less sympathomimetically potent quinones (Ar=0).1-6 The usual agents that catalyze the oxidation of colorless phenolic drugs, often to colored products such as the semiquinones, quinones, and adrenochromes, were reviewed elsewhere.14-15 The phenoxide anion (Ar--0~) is more sus ceptible to oxidation than the undissociated Ar--OH group, and the oxidation rate of the --OH group decreases in the order of the ortho, para, and meta positions.1-6-16 The chemical stability of several sympathomimetic cat echolamines mixed with large-volume parenteral (LVP) solutions has been reported.15-17-21 These studies15-17-21 found that catecholamine degradation (autoxidation) in creases sharply above a pH of 6. Thus, substituting a typical pKa of 9 for the most acidic phenolic --OH group into equation l,14-22 it is apparent that as little as 0.1% of phen oxide ion can catalyze the oxidation of Ar--OH to Ar=0 at a pH of 6. % dissociated = 100/[1 + antilog (pKa -- pH)] (1) There appear to be no published data on the stability of catecholamines in i.v. admixtures with aminophylline, al though warnings against preparing such solutions have been proffered.13-23 The purpose of this investigation was to obtain kinetic data through a stability-indicating assay method for the autoxidation of five sympathomimetic catecholamines and terbutaline sulfate mixed with 5% dextrose injection in the presence and absence of aminophylline. Although cur rently terbutaline sulfate is only approved for subcutaneous injection, it was included because of its investigational i.v. use in treating premature labor. Methods HPLC Assay. A paired-ion high-performance liquid chromatographic (HPLC) assay using a variable wavelength fluorometric detector was developed because it offered the advantages of: (1) expediency, (2) specificity and sensitivity 1314 American Journal of Hospital Pharmacy Vol 38 Sep 1981 nnn?.Q?ao/8i/noni.ni4ni xn BFG TECHNICAL DOCUMENT dUFGoodrich Chemical Division RESEARCH AND DEVELOPMENT REPORT ::n; :)A"a analv.'.; ppdgpam : par : : - v.trs manual by D. T. POPOVICH 4382 4 Project No. _______ Report Typo ^ersjjtanual llProm CantorPiasticSDolo Sept 9 >_ *1 Copy Approval Authority -3 DISTRIELfTION *: . 'after. A. Davidson *: ?. ,'ri ier/C. A. Darnels * . E. Flerung/R. M. Kreager t . L. Gardner et al. ?. o. Hong et al. r. F. V. Lloyd/C. N. Bush D. Longewey . 0. Lott f. h. Marty/H. L. Brandt *B. k. Mikofalvy/R. D. Hardesty d. E. Witanhafor i. I. Yieh et al C. T. P. (0* .'iality Control Lab (3) 'roup File (2) Bfwxsvn LLE *' Fawcett * . A. Glass/G. F. Thonpson ` . Ley/C. H.Luftrr . . Sc* lat iter >hi*-e/T !i. For ,-y the * rrur: "opies Only Wi tenhafer CLEVELAND *N. R. Aquino/E. C. Martinelli F. J. Donat A. L. Hastings/L. M. Puckett *j. C. 'ealy/F. E. Krause *R. A. Krueger/V. S. Lodge M. M. O'Mara G. D. Schaaf/B. C. Knoble R. F. Schubert/C. A. Marshall P. T. ShannorvN. J. level 1 J. W. >*61861.13. F. Carroll LOUISVILLE *E. L. Beeler. 13. . ''..tnuk M. J. Carmack/s. T. Pr.-u-n NIAGARA j. Dunn/P. olivet C. Brooks "R. Chaw la PEDRICrrOWN T. Nosai/VI. A. (`AI.VERT Cm T.'V. Pit/ lQUO BFACV n". Moore I i 21134001 PVC RESIN TESTINO DATA ANALYSIS PROCRANS PART J USERS MANUAL 8Y D T POPOVICH ABSTRACT Computer programs for the PVC resin tasting data analysis hav* baan written in a data fila oriantad fashion so as to provide a single summary report, including comments, of all tests run on a resin sample, while maintaining a record of multiple samples in progress These programs replace the Nonroe calculator and are currently available for use in PVC manufacturing resin testing labs wherein computer support.is available SCOPE For several years the data analysis in the PVC Resin Testing ' ab was performed via the Honroe 1860 programmable calcjlator Th-se programs ware for analysis of particle site and porosity (HO They were supplied to us. as to all production plants, by the manufacturing services group. In addition to those, we had written some additional programs to porform th# calculations for Inherent Viscosity. Bulk Density etc. In anticipation of the obsolecanca of tho Nonroe I860, wo decided to provide these sea# services as part of the installation of tho AI.TC Modcoa* 7870. This sms indeed one of tho first tasks completed on this now computer. Because tho Nodcomp 7870 Is to servo as the host coa^utor to several satellite computers which collect data from various eiperlmentel facilities, wo decided to net only perform data analysis for the laboratory but to dosin the system such that it would ho compatible with a imere automated data retrieval system In keeping with this goal 0 system was designed to inalyie data from the testing lab and ms intain temporary files on each sample until testing Is complete, Then a report of the test results is written. See tho following page for an oiample of this summary report. This users manual i* Part I of tba docuawntation for this system. Part II will daal with the mathematical treatmant of tho data and soma programming considerations. Highly commented program listings are available from the author on reguest. CONCLUSIONS AND SIGNIFICANCE 1 Programs for analyiing PVC Resin Testing data havs bsen written in a high level programming language (FORTRAN IV) 2 Those programs osist in two forms: (1) stand-alone versions which porform data analysis only and (2) a file oriantad system which accumulates a summary report of all taste 3 These programs can ba usad in any of the production plants using Nodcomp Computers with minimal changes and can easily be adapted for use on other computer equipment supporting FORTRAN IV This system, which is a complete replacement for the Nonroe calculator, has bean written to easily intr*ic* > " altc data ratripval system tp it developed In tho future 3(4$T T Z BFG10710 PVC RESIN TESTING LAB AVON LAKE TECH CENTER BLDG Aij SAMPLE IDENTIFICATION: MANUAL REQUESTED BY POPOVICH DATE IN 9/ 4/1981 DATE OF REPORT PLANT LOCATION ALT': PROJECT NO 1234 9/ 8/1961 TTME OF RFPORT io IP p ART I CLE SIZE * POROSITY (HO) AVER PORE 91ZE CUMULATIVE * PORE SIZE DIST MESH -- X ON -- X ON -- X THRU ------ * FINES POROSITY * FINE PGR/TCTL POP 40 2 34 2 34 60 43 IS 43 68 34. 32 INHERENT VISCOSITY 80 34 32 80 20 19 80 APPARENT BULK DENS 10O 10 66 90 86 9. 14 * COMPACT BULK DENS 140 8 63 99 49 0 31 FUNNEL FLOW 200 0 31 100 00 0. 00 * POWDER MIX TIME PAN 0 OO 10O 00 0 00 DOP POROSITY ^AT LOSS....................... AVER PART SIZE 241 37 MICRON BENNER FISH EYE PART SIZE DIST - 33 33 PERCNT * STATE OF GLASS.......... COARSE FRACTION 43 68 PERCNT TOTAL SOLIDS............... FINE FRACTION - 0 31 PERCNT * APF. PACK. FRAC COM. PACK. FRAC CUMULATIVE * MESH X ON X ON X THRU 0 260 ML/GM 0 672 M I CRN 99 338 V. 0 089 ML/G.' 341 0 937 0 309 or./ML 0 3H3 OM/Ml 20 7 SEC 330. 0 SEC 0 230 CC/GM 0 090 X 87 1 730 3 933 X 0 496 0 368 40 60 80 100 140 200 PAN 0 OO 1 31 22 11 29 13 34 67 9 03 3 01 0 30 2 01 24 12 33 27 87 94 96 99 100. 00 99 30 97 99 73 88 46 73 12 06 3. 01 -0 00 * * AVER PART SIZE - PART SIZE DIST - COARSE FRACTION. . - FII FRACTION - 133 06 MICRON 33. 42 PERCNT 1.91 PERCNT 12. 04 PERCNT * HERE HE CAN AOO ANY COMMENT IN FREE FORMAT UP TO 70 CHARACTERS AMD NE GAM CORRECT TVCH BEFORE THEY ARE 8T0RED THIS II A COMMENT ENTERED THROUGH THE COMMENT PROGRAM WE CAN AISO CORRECT THESE 3AHRLE ID MANUAL COPY FOR POPOVICH REQUESTED BY POPOVICH DATE 9/ B/19G1 TABLE OF CONTENTS ABSTRACT SCOPE CONCLUSIONS AND LIST OF FIGURES SIGNIFICANCE I INTRODUCTION II TERMINAL MONITOR PROORAM (TMP) III BATCH PROCESSING PROGRAM (JOB) IV SAMPLE ORIENTED PROGRAMS IV I SAMPLE PROORAM IV 2 COMMENT PROGRAM............................ IV 3 DIRECTORY PROGRAM............................ IV 4 REPORT PROORAM.................................... V DATA ANALYSIS PROGRAMS............................ V 1 COMMON CHARACTERISTICS.................. V 2 8TAND-AL0C VERSIONS....................... V 3 PARTICLE SIZE PROGRAM.................... V 4 POROSITY (HO) PROGRAM................... V 3 APPARENT BULK DENSITY PROORAM. V 6 COMPACT BULK 0EN8ITY PROORAM. . V 7 POROSITY (OOP) PROORAM.................. V 8 STATE OP GLASS PROORAM.................. V 9 HEAT LOES PROOA*1............................ V 10 IMl RENT VISCOSITY PROGRAM . V it TOTAL SOLIOS PROGRAM.................... V 12 BENNER FISH EYE PROORAM............. V 13 FUNNEL FLOW PROORAM. v 14 POWDER MIX TIME PROORAM BFG10712 frOOfrCTTZ LIST OF FICURES 1 PROCRAM SAMPLE (SAMPLE) 9 2 PROCRAM COMMENT (COMMENT) 12 3 PROCRAM DIRECTORY (DIRECT) 13 4 PROCRAM REPORT(inttrim) (REPORT) 14 5 PROCRAM REPORT (final) (REPORT) 16 6 PROCRAM PARTICLE SIZE....................... (APS >18 7 PROCRAM POROSITY (POR >22 8 PROGRAM APPARENT BULK DENSITY (ABD >27 9 PROGRAM COMPACT BULK DENSITY . . (CBD > 28 10 PROGRAM POROSITY (OOP)(OOP >29 11 PROGRAM STATE OF GLASS (OLAS). 30 12 PROGRAM HEAT LOSS (HL >31 13 PROGRAM INHERENT VISC08ITY (IV >32 14 PROGRAM TOTAL 9QLID8 <TS >33 19 PROORAM BENNER FI8H EYES................ (BEN ) 34 16 PROGRAM FUNNEL FLOW (FF > 39 17 PROGRAM POWDER MIX TIME.................. (PMT > 36 21134005 I INTRODUCTION 3 M tSSSBiMMMQIdBSI T h a QCLAB sgttem i * designed to accapt data from tha many testi performed in th* r asm tatting lab. ttora thata result* m a fil# until all th# test t from a particular tamp la have been coir.pltteo and than wrlta a c omprahantiva raport of tha raiultt from thata test* In ordar to accomplish thit. thara ara two tgpas of program* involvad in tha tgttam. Tha firtt catagorg of programs is designed to contro 1 tha fllat attociatad with aach tamp la Tha ttcond catagorg ha t programt that procatt ta*t data and store tha raiultt in tha Ml at. Flnallg. two additional subjects will ba addressed In this manual Thata ara tha Terminal Monitor Prc;rn (TMP) and tha Bate h Processing Program <JOB>. II TERMINAL MONITOR PROGRAM (TMP) fWRaMataMBaaa--mm Tha purpose of thit program it to allow tha wtor to concrol tr.a activitg at hit terminal. Thara aro throe items related to TMP with which tha QCLAB ustr need ba concerned. Thata aro: (1) tha abilitg to otart th* BATCH program. <2> to abort an oiocuting program or O) to interrupt a program that it oiocuting. To invoke TMP tho utor hat tha option of oithor of two actions: (1) ittuo a 'break' command with tho break keg on the terminal or (2) 'control A' where gou must hold down tho control keg and the character 'A' aimultaneoutlg. In either of thoto cates TW will be Invoked and th* computer will proa^t the user with a '>' character to indicate that TMP it readg for a command Tha user than will rotpond bg: 1 RUN BAT Thit will causa tho BATCH (JOB) protram to oiocute and < the prompt character '' to appear indicating that JOB it waiting for a cotMtand. /A Thit will cause the eiecuting program to abort and return control to JOB NOTE It it good practice to lttue a JOB command after aborting a program. (praa^t character) I (gou input) (prompt character) /R This will causa an Interrupted program to resume eiecutian. Ill BATCH PROCESSING PROGRAM (JOB) Th* purpota of this program it to allow th* eiecutlon of other programs and to establish th* proper environment to that th* input and output to theta programt it praperlg directed. The prompt character for JOB it th* 'O' Whenever thit character it th* last item an tha screen. JOB will accapt a command. The keg te the lab sgttem it th* JOB comaMnd 'QCLAB' followed bg th* naaM of th* program that it to be eiocuted An optienal third parameter mag b* entered in this sequence to allow outpvt to th* CRT rather than BFG10714 21X34006 t-i* Diciantir This allows the suppression of the herd copy whenever it is not needed A typical commend to JOB would b* s QCLAB SAMPLE (prompt character output by JOB' (input by user to call the program SAMP' ) or e OCLAB DIRECTORY TY (input by user to eiecute the program DIRECTORY and have the output appear on the CRT rather than on the printer IV SAMPLE PILE ORIENTED PROGRAMS IV 1 PROCRAM SAMPLE This it the Min program for sample file control. When the sample identification is entered, the program searches the files and attempts to locate the sample file. Sample identification may consist of one to siiteen charactors entered in free form. Examples SA 1334* SEC 4967i P76. Other eiamples can bo found in figure 3. During the search two possibilities osist: 1 A file by that name is not located and the program assumes a now file is going to bo entered. 2 A file by that name is located and tho program assumes an update of this file is required. Each of these cases mill bo discussed. New sample If the sample is new. the program will ask for certain background inforeuitlen. This will include tho name of the requester, the plant location and the project number. After this step is completed, the program will ask to have the tests which are to be run on this sample Identified. A verification step is included in which the regwestod tests are output to the user for ver i." lc.tton and correction. The tests which have been requested are then identified in the saddle file. The reguested tests are flagged in this manner so the system can track the tests which need to be run The final task which is performed is to allow the entry of tree-form comments about this sample. These My be used to identify tests which are to be run. but are not Included in the list of standard tests The results of theso special tests My also be entered in the coeHsent section of the files. However, these would be input using the program 'COMMENT' (see program COMMENT' below) A maximum of ten coewents is allowed in eech tile 2X134007 J1 .1 tempi# the ijmplt f 1 1 which hit been idtntiMid it already, in t r e fllf, th* program iftuin that an update of thi file .s mi-ei Firtt the program interrogate# tha uter to dittrmini if the f,.i it to be d 1 t d If th 11 it tha cate. a pattword mutt ba n>rM btfora d1 ation occurt If dalation it not intandad. tha program than procaadt to tha 'ADD'/'DELETE' routina In which tha requested tattt ara idantifiad and corractiont ara mada Tha program will than go to tha comment entry routina for additional comments When th i t updata It complata. th* tamp la fila It ra-wnttan If thit program it abnormally tarminatad (i a. by an abcit or tome >.nar t'lttam avant). tha fila will not ba re-written and tha .li will not occur In thit cata tha fila will raaain at it wat prior to thit call Eiamplat of thaia appaar in Figura 1 IV S PROGRAM COMMENT Thit program allowt tha antry of comment# into a tamp la fila Tha program atkt for tha tampla 1 dantification Whan tha taaipla it locatad in tha filaa tha utar antart tha coaHnt(t) in a fraa-form of up to 70 character# Prior to writing tha comment into tho filat tha prograai will writa it back to tho utar for verification Whan tha coaaant it verified it will ba writtan into tha fila and antry of another comment will ba regueated. Whan all tha coaaantt have baan entered, tha command 'DONE' will tarminata tha program Eiampla appaart in Figura 2. Iv 3 PROCRAM DIRECTORY The purpota of thit program it twofold 1 It littt all tha tamp lot currently in tho fila 2 It tarvat at a rafaranca to determine eiactly how each tampla it idantifiad. If. whan antaring tha tampla identification into any of the programt in thit eyetem. any charactar or tpaca it not aiactlg tha aewe at whan it wat initielited- tho temple will not ba found. IV 4 PROGRAM REPORT Thit program it utod to report tho reaulta In addition, two other functiont art performed by thit program Tho firat of theta la to check tha data fila and confirm that all data from all tha test: that have baan regueated it preaent If thit it not tha cata. tha tet for which data it miaalng will ba identified and tha utar will ba aeted if an interim report theuld ba printed A final report will not bo written until all tha regueated teata ara reporta4 1* rertaln t?tt ara m longer needed, they mutt ba m&wm BFG10716 J<*leted using the program SAMPLE' before the final ftport Jill be i.lawid Sine* the completion of the final report results in tne Jeletion of the lenpli fil*. th1i routine provides some protection for the fi lit If all tha data is present. a final report mill ce printed in triplicate One of then copiet nil 1 1 be ilenMMH *" be kept in the lab at tha permanent record of the test results Tne copy will be identified to be sent to the requester j f the tests The third copy mill be identified to be sent to data retrieval When these three copies have been printed, the user mill be asked to verify that they are complete If the reports are complete, the sample is removed from the files If the report is not satisfactory, the program will exit Aftr the cause . c unsatisfactory report is corrected, the user can recall this program and print out the report Interim report This report can be issued if testing is not complete Unlike the final report, only one copy will be printed This report is also identified as an interim report When this report is Issued, the tests that have been requested and have not been reported will be flagged with a negative test value. Examples of an interim and final report can be found in Figures 4 and 3 V DATA ANALYSIS PROGRAMS The purpose of each of the programs in this category is to accept data from the various tests, process that data and write the results of the data analysis or data input into the sample file U 1 COMMON CHARACTERISTICS The programs in the data analysis category have certain common characteristics These programs, like the file control programs, are called by the JOB comauand 'QCLAB tttt'i where XXXX is the name of the program. In each of thoeo programs tho same method of sample file identification, sampla file location and exiting is used All tha programs remain active until tho exit is requested by tho csapanl 'DOC' This allows many samples on which the tame test has baan perforaw d to bo processed without having to recall the program Par each cample In each of these programs, the ueer will bo aliassed two attempts to ontor the sample jeent. f uat ion If tho file is not located after the the eecond attempt, the program will exit to allow the user to check the file directory be moans of program 'DIRECTORY' to verify tho temple file exists and the correct identif1caton is being ueed In the following sectione a summary of the features of each program will be discussed There are examples of sach of these programs in the figures at the end of this atanual There art two types of programs in the date analysis category Some of the oMgnpi in this cateoory ere merely vehicles for the data to be entered into the files That is. some of the test results romlit BFG10717 6006-8TTZ of a tingla va 1 ua and no cilculitiont ir met uiry to ivaluate tha data Thtst art 1 BENNER PISH EYES 2 FUNNEL FLOW 3 POWDER MIX TIME (PROGRAM BEN) (PROORAM FF) <PROGRAM PMT> Each of tha othar prognat In this unit parfora torn# typa of calculation V 2 STAND-ALONE PROGRAMS Occasionally< a feast say ba raguirad whara feha raquastar dos not with to havt feha antira raporfe ar.tarad into feha sysfeam To accoausodafea this, aach of feha programs In which calculations art parforaiad has a complimanfeary program that pa'foras feha calculations tut dots not lntorfaco to tha sacipla Tilts Thasa ar# callad 'STAND-ALONE PROGRAMS'. Thasa coap1Imanfeary programs art callad by appanding an 'A' onto feha ragular naaai for aiampla 'APS' bacoaas 'APSA Tha following grograas do data analysis and thus hava sfeand-alona varsions 1 APPARENT BULK DENSITY 2 PARTICLE SIZE ANALYSIS 3 COMPACT BULK DENSITY 4. DOP POROSITY................................. 3 STATE OF GLASS............................ 6. HEAT LOSS......................................... 7 INHERENT VISCOSITY 8. POROSITY (HO)............................... 9 TOTAL SOLIDS (PROGRAM ABD or ABDA) (PROGRAM APS or APSA) (PROGRAM CBD or CBDA) (PROGRAM DOP) fe (PROGRAM OLAS or CLASA) (PROGRAM HL or HLA ) (PROGRAM IV or IVA ) (PROGRAM POR or PORA) (PROGRAM TS or T8A ) V 3 PARTICLE SIZE Program Faaturas 1 Thara is eurrantly a salacfeion of four scraan packs a. Mask siias ao. *o. ao. ioo. iao. 300 b Mash Sitds *0.100.170.300.330.370 c. Mash siias 30. 40.SO.60. 80. 100 d. Mash sltas 40.90.40.70. 90. IOO Ona lacfead pri t 3 lacausa af feha nwahar of data points that ara to ba anfearad for this feast, a data adlting routina has baan providad to allow feha usar to inspacfe and corract feha data bafora any calculations ara parferaad. H* the file and indeies to the second storage area The if should not* that 1# a third set of results it tntirid. it ui i : ripliCI the ttcond set On those r#ri occdtioni when the Jir wiihpt to replace the firt sot of results. th* results of the first test may bo dalatad using the program `SAMPLE' Tr* . i-- particle site program will accept the nait data set end enter the results into the first file position Example appears in Figure 6. v 4 POROSITY (Mercurg Intrusion) There are two features of special note In the porositu analysis 1 After the user has entered all the data for this program, an editing routine is called that allows the user to inspect the input data and correct the sample weight and/or the penetrometer "stem* readings. The program remains in this mode until the data is approved bg the user. 2 Occasionallg a request is made for the porositg of the fines from a sample and a report of the ratio of the fines porositg to the porositg from the entire sample. The porositg program has been written to accommodate this request. This is accomplished bg having the program determine if a porositg result is alreadg present in the file. If the result is there, as it must be for the fines porositg to be calculated, the user is given the option of entering the data as a fines porositg or replacing the results from the previous regular porositg. The selection of this option will be clear bg inspecting the examples in Figure 7 Example appears in Figure 7. V 3 Apparent Bulk Densitg There is just one feature of special note in this program. Normallg. onlg one cup is used for this tost in each xb The tare weight of this cug is unlikelg to change enough to af< -t the test This taro weight has been put into the program and the user need not enter it. If an occasion should arise where this cup is changed* a change in the program will be required. This program requires onlg the entrg of the sample Identification and the gross weight of the resin and the cup Therefore no date correction features are Included in this program If an irro* it made in data entrg and the reeults are written into the files. th* user need onlg re-enter the sample identification and the correct gross weight. The results will be updated in the files Example appears in Figure V 6 Coapict 8ulk Density Thi* program it vary much Ilka tha Apparant Bulk Dantity program On# dtfharanca it that tha tara waight of tha graduate mutt b* antarad for aach tanpt of aaaplaa At a convanianca to tha tha tara waight of tha graduata naad only ba antarad onca at th boginning oh tha program. Tharafora> tha program niuaai that each tampla mat run with tha tama graduata. If for torn* raaton tha graduata was changad during a tariat of tastt. tha program must ba racallad to antar tha tara waight of tha naw graduata In this program only two itami of data ara required tor aac^ tampla (batida tha graduata tara waight) Thata ara tha grots waight of tha tamplo/graduata and tha voluma of tha tampla This program doat not provido any tpacial data aditing faaturci At with tha othar programs, if data corractlon it required. tha uut timpla re-enters tha sample idantiflcatlon and iht corrected data and tha filat will ba updatad. Eiaa^la appaart in Figure 9. V. y POROSITY (OOP) Program Faaturoa 1. Tha density of OOP at 30 dag. C. it part of this program. To accoawodata tha occasional uoa of anothar platticiiar or a changa in density dua to a changa in tamparatura. tha density valua can ha changad bafara tha taot data it antarad. Eiae^le appaaro in Pigwra 10. Tha following programs have no tpacial faaturas and tha oparation of aach of thaoa is oalf aiplanatorg. STATS OF 0LAS8........................... (LAS) HEAT LOSS............................................ (HL> IMCREMT VISCOSITY.....................(IV) TOTAL SOLIDS.................................... (TS) FISH EYES..........................(BEN) FLOW.................................. <FF) MX TIME............................ (PHT) Eiampleo af aach af thaoa programs appaar in Figurat 11 thru 17 21134012 FIGURE 1 OP 3CLA0 sample ASS 1-TV 3-ATO RAD-QCD LMT-QCM EXE SAMPLE. LMT INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE MANUAL ENTER EXPERIMENTER IDENTIFICATION (UP TO 8 CHAR ) POPOVICH ENTER LOCATION IDENTIFICATION (UP TO 8 CHAR ) altc ENTER PROJECT NUMBER 1234 ENTER TEST TO BE ADDED (ENTER DONE AFTER LA8T TEST ENTERLD THE TESTS NOW AVAILABLE ARE: APS APS2 POR FPOR LAS DOP TS AVERAOE PARTICLE SIZE SECOND SCREEN PACK POROSITY FINES POROSITY STATE OP LASS OOP POROSITY TOTAL SOLIDS * BEN PMT AID CBD PP IV HL BENNER FISH EYE 6 MIN POWOER MIX TIME APPARENT BULK DENSITY COMPACT BULK DENSITY FUNNEL PLOW INHERENT VISCOSITY HEAT LOSS PLEASE ENTER (BE OF THESE. IF THE TEST YOU WISH DOCS NOT APPEAR ON THIS LIST THE RE9ULT MUST BE ENTERED THROUGH THE PROGRAM "COMMENT* FOR IT TO APPEAR ON THE FINAL REPORT ENTER TEST TO E ADDED (ENTER DONE AFTER LAST TEST ENTERED) APS ENTER TEST TO BE ADDED (ENTER DONE AFTER LA8T TEST ENTERED) APS2 ENTER TEST TO BC AOOED (ENTER DONE AFTER LAST TEST ENTERED) POR ENTER TEST TO BE AOOCD (INTER DOME AFTER LAST TEST ENTERED) FPOR ENTER TEST TO BE ADDED (ENTER DONE AFTER LAST TEST ENTERED) LAS ENTER TEST TO C ADOCD (INTER DONE AFTER LAST TEST ENTERED; DOP ENTER TEST TO BC AOOCD (ENTER DONE AFTER LAST TEST ENTERED) TS ENTER TEST TO BC ADOCD (ENTER DONE AFTER LAST TEST ENTERED) BEN ENTER TEST TO BC ADOCD (ENTER DONE AFTER LAST TEST ENTERED) PMT ENTER TE9T TO C ADOCD (CNTCR DONE AFTER LAST TEST ENTERED) ABO ENTER TEST TO ME ADOCD (ENTER DONE AFTER LAST TEST ENTERED) CBD 21134013 BFG10721 FIGURE 1 continued ENTER TEST TO BE ADDED (ENTER DONE AFTER LAST TEST ENTERED FF ENTER TEST TO BE ADDED (ENTER DONE AFTER LAST TEST ENTERED IV ENTER TEST TO BE ADDED (ENTER DONE AFTER LAST TEST ENTERED) te,, TEST TO BE ADDED (ENTER DONE AFTER LAST TEST ENTERED) DONE THE TESTS YOU HAVE REQUESTED ARE APS POR AID C1D FF IV HL BEN PUT OCAS APS3 OOP TS FPOR IS THIS LIST COMPLETE AND CORRECT 7 NO not*: hor* it oaoaplt *# to* w* upBoto thit Bilo. DO YOU WISH TO -ADO" OR "DELETE- A TEST DELETE not*: too* v* Mill Boloto PP. ENTER TEST TO DELETE (ENTER DONE AFTER LAST TEST IS ENTERED) FF not*: thit Mill rtotvo PP fro* tko list. ENTER TEST TO DELETE (ENTER DONE AFTER LAST TEST IS ENTERED) DONE not*: m *f>* Bon* Bolotin* t*t THE TESTS YOU HAVA1 RESUESTED ARE: APS POR ABD CBD IV HL BEN PUT OLAS APES DOP TS FPOR IS THIS LIST COMPLETE AND CORRECT 7 NO not* lot'* put PP hock In. DO YOU WISH TO "ADD" OR "DELETE" A TEST ADD KOfrSTTZ FIQURE 1 continued ENTER TEST TO BE ADDED (ENTER DONE AFTER LAST TEST ENTERED) FF not* FF goat back in. ENTER TEST TO BE ADDED (ENTER DONE AFTER LAST TcST ENTERED) DONE not* wa ara now dona adding. THE TESTS YOU HAVE REQUESTED ARE APS POR ABD CBD FF IV HL BEN PHT LAS APSS OOP TS FPOR IS THIS LIST COMPLETE AND CORRECT ? ______ YES not*: now wo go on to tbo noit atop* COMMENTS ARE THERE ANY ADDITIONAL TESTS THAT ARE TO SE RUN OR OTHER COttCNTS YOU WISH TO MAKE ABOUT THIS SAMPLE ? YES ENTER COMMENT HERE WE CAN ADO ANY COMMENT IN FREE FORMAT UP TO 70 CHARACTERS HERE WE CAN ADO ANY COISCNT IN FREE FORMAT UP TO 70 CHARACTERS IS THIS CORRECT 7 YES not*: tha caaaant is vtrlliid as correct. ANY MORE COMMENTS 7 YES noto: add anotkar co--awt. ENTER COISCNT AND WE CAN COLLECT THEM BEFORE THEY ARE STORED AND WE CAN COLLECT THEM BEFORE TVCV ARE STORED IS THIS CORRECT ? NO ENTER CMIHT ANO WE CAM CORRECT THEM BEFORE THEY ARC STORED AND WE CAN CORRECT THEM BEFORE THEY ARC STORED IS THIS CORRECT 7 YES ANY MORE CMBCHTS 7 no nt: ws naw dana and tha prograai will aiit. 21134015 FIGURE 3 JOB * QCLAB DIRECTORY ASS 1-TY 3-ATC RAD-QCD LMT-QCM EXE DIRECT,LMT i ?. SAMPLE DIRECTOPY**# SA 2139 25KPAS F76 SA 2149 81. 86 SA 2143 799KPAS MANUAL SA 21461 799KPA8 9179 9180C UA 1904 SEO 349 9197 8A 2146 70X 9173 9168 SA 2148 799KPAS 9196 8A 2140 29MPAS SEO 347 UA 1904 8EQ 348 MA 1909 91S1C 91o4 SEu 3*o SA 21461 60X SA 2136 29KPAS 9179 UA 1906 28 SAMPLES IN DIRECTORY STOP DIREC JOB END 8CLAB FIGURE 4 - GG JCLAB REPORT ASS 1-TY 3*ATC RAD-QCD LMT-QCM EXE REPORT.LMT INPUT SAMPLE IDENTIFICATION MANUAL IS THIS A FINAL REPORT ? NO not* You Mill notice that this i on interim report Th* valuat oP th* t*t raault* Mill eh hava baan raguatad ar* all nagativa. Wa Mill output th# Pinal raport in Figura 3. 8T0frTT2 PVC RESIN TEST I NO LAB AVON LAKE TECH CENTER BlDL 413 SAMPLE IDENTIFICATION MANUAL REQUESTED BY POPOVICH DATE IN 9/ 4/1981 DATE OF REPORT PLANT LQr AT I ON ALT/ PROJECT NO 1234 9/ 8/1981 TIME OF REPORT 8 49 * P ART I C L E SIZE * * POROSITY <HO I > AVER. PORE SIZE = CUMULATIVE PORE SIZE DIST MESH -- X ON -------- X ON -------- X THRU FINES POROSITY FINE POR/TOTL POT -1 0 00 0 00 100. 00 -1 0 00 0 00 100 00 INHERENT VISCOSITY -l 0 00 -1 0.00 0 00 0.00 100. 00 100. 00 APPARENT BULK DENS COMPACT BULK DENS -1 0.00 0.00 100. 00 FUNNEL FLOW. -1 PAN 0.00 0 00 0 . 00 0. 00 100. 00 100. 00 POUOER MIX TIME. OOP POROSITY HEAT LOSS....................... AVER PART SIZE - -1.00 MICRON BENNER FISH EYE PART SIZE 0IST - -1.00 PERCNT STATE OF SLA8S. . COARSE FRACTION. - 0. 00 PERCNT TOTAL SOLIDS............... FINE FRACTION 0. 00 PERCNT APP PACK. FRAC MESH X ON CUMULATIVE X ON X THRU -1 000 ML /GM -1 000 M I CRN -1 000 */, -1 oco -- i coo -l 000 -l 000 JM/ML -i ooo CM/ML 1 0 SEC i. 0 SEC -i. 000 CC/QM -l. ooo X -l -l. 000 0 000 X 0. 000 0 000 < -I -l -1 -1 -1 -1 PAN -0 00 0 00 0 00 0 00 0 00 0 00 000 0 00 0 00 0. 00 O 00 0 00 0.00 000 100. 00 100.00 100 00 100 00 100 00 100 00 100 00 AVER PART. SIZE PART SIZE DIRT COARSE FRACTION. - FINE FRACTION - -1 00 MICRON -1. 00 PERCNT -O 00 PERCNT 0. 00 PERCNT MEM Mi CAN ADD ANY COMMENT IN FREE FORMAT UP TO 70 CHARACTERS AND UK Cm CORRECT THEM BEFORE THEY ARE STORED THIS IS A COmCNT ENTERED THROUGH THE COMMENT PR OOP AM HE CAM ALSO CORRECT THESE to se o H* to AAMPLF ID MAHiWM INTCR1H fttPOMT REQUESTED BY: POPOVICH OATC 9/ B/' l 9 1 BFG10727 FIOURE 3 JOB QCLAB REPORT ASS 1-TY 3-ATQ RAD-QCD LHTHKH EXE REPORT.LMT i o. INPUT SAMPLE IDENTIFICATION IS THIS A FINAL REPORT 7 YES not*. Tbit i o Final report. IF any of til* toots wiich have boon requested have not boon reported, tbo proproa will infora you t tbit tin# and prevent tbo Final report Area being written ion tbo reports oro written. DID THE REPORT CIRC OUT ALL RIGHT 7 NO note: Tbit will cm* tbo prepraa to oilt without reoMvinp tbo staple Area tbo File*. See section IV. 4 Final Roport. YES noto: Tbis will cause tbo Filo to bo r ved. and tbo propron will tbon oiit. 21134020 BFG10728 i7 uvC RESIN TEST INO LAO AVON LAKE TECH CENTER 8LDC 413 SAMPLE IDENTIFICATION manual REOLESTED BY POPOVICH DATE IN 9/ 4/1981 DATE OF REPORT plant location ALTC PROJECT NO 1234 9/ 8/1981 TIME OF REPORT LO 12 P AR T I CLE SIZE POROSITY (HO) AVER. PORE SIZE CUMULATIVE PORE SIZE DI8T MESH X ON X ON X THRU * PINES POROSITY -- -- -- FINE POR/TOTL POR 40 2 94 2 34 97 46 60 43 19 43 68 34 32 INHERENT VISCOSITY 80 34 92 80 20 19 SO APPARENT BULK DENS lOO 10 66 99 86 9. 14 COMPACT BULK DENS 140 8 63 99 49 0. 31 FUNNEL FLOW................. 200 0 31 100 00 0 00 PONDER MIX TIME PAN 0 OO 100. 00 0 00 DOP POROSITY HEAT LOSS AVER PART. SIZE 241 37 MICRON BENNER FI8H EYE PART SIZE DIST - 33 33 PERCNT STATE OF 0LA8S. COARSE FRACTION. - 43 68 PERCNT TOTAL SOLIDS............... FINE FRACTION - 0. 31 PERCNT <#P. PACK. FRAC. --- --f COM. PACK. FRAC. . . CUMULATIVE FC9H X ON X ON X TKitU 0 260 ML/CM 0 672 MICRN 99 938 X O 089 ML/CM w J4I o 937 0 909 QM/Mi_ 0 983 GM, KL 20 7 SEC 330 0 SEC 0 290 CC/OM 0 090 X 87 1 730 3 999 X 0 496 0 968 40 60 80 lOO 140 200 PAN 0 00 1 31 22 11 29 13 34 67 9 03 3. 01 0. 30 2. 01 24 12 33 27 87 94 96. 99 lOO 00 99. 30 97 99 73. 88 46. 73 12. 04 3.01 -O. 00 AVER PART SIZE - 133. 06 MICRON PART SIZE DIST. - 33. 43 PERCNT COARSE FRACTION. - 1.31 PERCNT FINE FRACTION 13. 08 PERCNT -> HERE UK CAN AOO ANY CONHENT IN FREE FORMAT UP TO 70 CHARACTERS AND ME CAN CORRECT THEM BEFORE THEY ARE STORES THI8 IS A COMNBMT ENTERED THROUGH THE COMMENT PROGRAM ME CAN ALSO CORRECT THESE fO h** 8 O *0 b* SAMPLE ID MANUAL COPY FOP LAI RC3UESTED BY POPOVICH DATS 9/ B/1981 PICURE 6 JOB * OCLAB APS ASS 1-TY 3-ATO EXE APS. LMT rad-ocd lht-qcm PARTICLE SI 2E*** INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE M6M1 |Ai STANDARD SCREEN PACKS ARE: 12 ---- 40 60 60 100 SO 170 too 200 140 200 230 270 3 -- 40 90 60 SO too 4 -- 40 90 60 70 90 100 INPUT DESIRED SCREEN PACK NUMBER INPUT TOTAL OAOLE UEIOKT 2 DTUT SCREEN 1 CROSS AND TARE HEIGHTS 40 71 40. 66 INPUT SCREEN 2 GROM AM) TARE HEIGHTS 38 04 37 24 INPUT SCREEN 3 GROSS M> TARE HEIGHTS 36. 64 39. 46 II*UT SCREEN 4 GROSS M> TARE HEIGHTS 39 44 39. S3 INPUT 8C8WM S GROSS AND TARE HEIGHTS 34 62 34. 49 INPUT rUt 6 GROSS AND TARE HEIGHTS 33 63 33. SI INPUT PAM MM AMD TARE HEIGHTS 199 28 1SS. SB SCAN GROSS TARE 1 40. 71 40 66 2 38. 04 37 24 3 36. 64 39. 46 4 39. 44 39. 23 9 34. 68 34. 49 6 33 63 33. 42 7 199. kU 199. da Z Z O tV T T Z FICURE 6 continued DO YOU WISH TO CORRECT ANY OF THESE WEIGHTS YES not* tar* on icrain 6 i incorrect ENTER SCREEN NUMBER TO BE CORRECTED 6 INPUT SCREEN 6 GROSS AND TARE WEIGHTS 33 63 33 62 BCRN GROSS TARE "> l *0 71 40 66 2 38. 09 37. 24 3 36 64 35 96 4 39 44 35. 23 5 34 62 34 45 6 33 63 33 62 7 159. 20 155. 28 DO YOU WISH TO CORRECT ANY OF THESE tuZIGHTS ? NO PARTICLE SI Z E INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER OOC* AFTER LAST SAMPLE DONE STOP APS JOS END SCLAB 21134023 H382 FIGURE 6 continued JOB QCLAB APS ASS 1-TY 3-ATQ RAD-OCD LMT-QCM EXE APS.LMT PARTICLE SIZE*** INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE MANUAL STANDARD SCREEN PACKS ARE: 12 ---- 40 60 80 100 140 200 60 100 170 200 230 270 3 -- 20 40 90 60 SO 100 882SSS INPUT DESIRED SCREEN PACE NUMBER 1 not*: mm mrm choosing scroon pock I. INPUT TOTAL RAIPLt HEIGHT 2 INPUT SCREEN 1 GROSS AND TARE HEIGHTS 40. 67 40. 66 INPUT SCREEN 2 GROSS A* TARS HEIGHTS 37 27 37. 24 INPUT SCREEN 3 GROSS AND TMIS HEIGHTS 36 40 33. 46 INPUT SCREEN 4 GROSS AM> TARE HEIGHTS 39.81 39.23 INPUT SCREEN 3 GROSS AMD TARE HEIGHTS 39. 14 34. 4S INPUT SMBS 4 GROSS MS> TARE HEIGHTS 33. SO 38.40 INPUT PMI GROM AMD TARE HEIGHTS 199.34 ISO. SS SCAN GROSS TARE 1 40. 67 40. 66 2 37. 27 37. 24 3 36. 40 39. 46 4 39. SI 39. 23 5 39. 14 34. 49 6 33. SO 33. 62 7 199 34 199. 28 BFG10733 FIGURE 7 JOB OCLAB POR BASS 1-TV 3-ATO RAD-OCD LMT-OCM 4EXE POR.LMT POROSITY PROGRAM I.4PUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE MANUAL INPUT SAMPLE WEIGHT 1613 6. 9 PSIA STEM READING 0 8 9 PSIA STEM READING 066 10 9 P8IA 8TEM READING 072 18 9 PSIA STEM READING 074 14 4 PSIA STEM READING 076 10. 0 P8I0 STEM READING 077 20. 0 PSIO STEM READING . 070 40. 0 PSIO STEM READINO 080 60. 0 PSIO STEM READING 082 0. 0 PSIO STEM READING 083 100 0 PSIO STEM READING . 084 120 0 PSIO STEM READING 089 140. 0 PSIO STEM READING . 086 160. 0 PSIO STEM READING 087 180. 0 PSIO STEM READING . 089 200. 0 PSIO STEM READINO . 090 300. 0 PSIO STEM READINO . 099 400. 0 PSIO STEM READINO . 101 900. 0 PSIO STEM READING . 107 1000. 0 PSIO STEM READINO 119 1900.0 PSIO STEM READING . 121 2000. 0 PSIO STEM READINO . 122 3000 0 PSIO STEM READING . 124 9000. 0 PSSS STEM READINO . 124 21134027 8 *5 FIGURE 7 continued SAMPLE WEIOHT 0 1613 PRESSURE STEM PRESSURE STEM 63 0 000 140 0 83 0. 066 160. 0 10 3 0. 072 180. 0 12 3 0. 074 200. 0 14 4 0. 076 300. 0 10 0 0 077 400. 0 20 0 0. 079 300. 0 40 0 0. 080 1000. 0 60 0 0. 082 1300 0 80. 0 0. 083 2000. 0 iOO 0 0. 084 3000. 0 120. 0 0. 083 ^000. 0 YOU WISH TO CORRECT ANY OF THESE VALUES YES ICHT OR STEM ? WEIOHT TER CORRECT WEIOHT . 1614 0 086 0 087 0 089 0 090 0. 095 0 101 0. 107 0 It9 0 121 0. 122 0. 124 0. 124 SAMPLE WEIOHT - 0. 1414 PRESSURE STEM PRESSURE STEM 6. 3 0. 000 140. 0 8. 3 0. 066 160. 0 10. 3 0. 072 ISO. 0 12 3 0. 074 200. 0 14. 4 0. 074 300. 0 10. 0 0. 077 400. 0 20. 0 0. 079 300. 0 40. 0 0. 080 1000. 0 60.0 0. 082 1300. 0 80.0 0. 083 2000. 0 100. 0 0. 084 3000. 0 120. 0 0. 083 5000. 0 1 TO CORRECT ANY OF THESE VALUES YES WEIOHT OR STEM ? 0. 086 0. 087 0. 089 0. 090 0. 093 0 101 0. 107 0. 119 0. 121 0 122 0. 124 0 124 BFG10735 FIGURE 7 continued . I. ENTER PRESSURE OF STEM READINO TO BE CORRECTED 2oC0 ENTER CORRECT STEM READINO 121 SAMPLE WEIGHT - 0 1614 PRESSURE STEM PRESSURE 6S 0 000 140 0 as 0. 044 160 0 1" 9 0. 072 ISO. 0 12 9 O. 074 200 0 14 4 0. 074 300. 0 lO 0 0. 077 400. 0 20 0 0. 079 JOO 0 40 0 0. OSO 1000. 0 60 0 0. 002 1900. 0 SO 0 O 003 2000. 0 100 0 0. 004 3000. 0 120. 0 0. 009 9000. 0 1 TO CORRECT ANY OF THESE VALUES NO STEM 0. 066 0 067 0 09 0 090 0. 099 0. 101 0. 107 0. 119 0 121 0. 121 0. 124 0. 124 0 R 0 S I T V PR 0 0 R A M INPUT SAMPLE IDENTIFICATION (UP TO 14 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE DONE STOP POR JOS END SCLAS 21X34028 FIGURE 7 continued i'Q % JC*.A3 POR *ASS 1-TY 3-ATG E <E POR.LMT rad-qcd lht-qcm POROSITY PROGRAM INPUT SAMPLE IDENTIFICATION (UP ENTER "DONE" AFTER LAST SAMPLE MANUAL THE POROSITY FOR MANUAL IS THIS A FINES POROSITY > YES TO 16 HAS CHARACTERS > BEEN ENTERED INPUT SAMPLE HEIGHT 1563 6 5 PSIA STEM READING 0 a 5 PSIA STEM READINO 002 10 5 PSIA STEM READING . oto 12 S PSIA STEM READING 010 14 4 PSIA STEM READING 012 10 0 PSIO STEM READING . 013 20 0 PSIG STEM READING 014 40 0 PSIO STEM READING . 015 60 0 PSIO STEM READING . 016 ao 0 PSIO STEM READING . 016 100 0 PSIO STEM READING . 016 120 0 PSIO STEM READING . 016 140 0 PSIO STEM READING 016 160 0 PSIO STEM READING 017 180 0 PSIO STEM READING . 017 200 0 PSIO STEM READING . 017 300 0 PSIO STEM READING . 019 400 0 PSIO STEM READING . 022 500. 0 PSIO STEM READING . 024 1000 0 PSIO tl! MACING . 027 1500. 0 PSIO STEM MACING . 020 2000. 0 PSIO STM MAOINO . 009 3000 0 PSIO STIH READING . 030 5000 0 PSIO STEM READING . 031 r FIGURE 7 continued 26 . SAMPLE WEIGHT - O 1363 PRESSURE STEM PRESSURE 63 0 OOO 140. 0 83 0 002 160. 0 10 3 0. 010 190. 0 12. 3 0 010 200 0 14 4 0. 012 300. 0 10. 0 0. 013 400. 0 20 0 0. 014 300. 0 40. 0 0. 013 1000. 0 60. 0 0 016 1300. 0 80. 0 0. 016 2000. 0 100. 0 0. 014 3000. 0 120. 0 0. 014 3000. 0 hi TO CORRECT ANY OF THESE VALUE8 NO STEM 0 016 0 017 0 017 0 017 0. 019 0. 022 0. 024 0. 027 0. 028 0 029 0. 030 0. 031 0 R 0 8 I T V PR 0 0 R A M INPUT SAMPLE IDENTIFICATION <UP TO 14 CHARACTERS) ENTER -DONE- AFTER LAST BATTLE I STOP POR 21134030 BFG10738 M S FIGURE 9 ca 3C.-43 CBD *A3S l-TV 3-ATC RAD-QCD LMT-QCM EXE CBD.LHT Ji . * COMPACT BULK DENSITY * * ENTER THE WEIOHT OF THE ORADUATE 187 6 INPUT SAMPLE IDENTIFICATION <UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SA**LE MANUAL INPUT DROSS WEIGHT AND VOLUME OF SAMPLE 312 42 214 INPUT SAMPLE IDENTIFICATION <UP TO 16 CHARACTERS) ENTER "DONE* AFTER LAST SAf*LE DONE STOP CBD JOB END OCLAB Z & iH T T Z FIOURE 10 .-OB v>Ci-AB OOP *ASS 1-TV 3-ATC RAD-QCD LMT-QCM EXE DOP.LMT * * * DOP POROSITY * * * I AM USING THE DENSITY FOB P-7S PLASTICIZER AT 30 DEC C WHICH IS 977 OH/CC DO YOU WISH TO CHANGE THIS VALUE NO INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE MANUAL ENTER TARE WEIGHT OF TIME 27 4 ENTER CROSS WEIGHT BEFORE PLASTICIZER 32 4 ENTER CROSS WEIGHT AFTER PLASTICIZER 33 62 INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DOTC* AFTER LAST SAMPLE DONE STOP OOP *vos ENO OCLAB KOW TO BFG10741 FIOURE 11 JOB QCLAB CLAS ASS l-TY 3-ATO RAD-QCD LMT-QCM EXE OLAS. LMT * * * STATE OF LASS ** INPUT SAMPLE IDENTIFICATION (UP TO 16 CHAPACTEAS) ENTER "DONE" AFTER LA8T 8AMPLE MANUAL INPUT THE SAMPLE WEIQHT. COUNTER READING AND TURNS 13 93 1.3 INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE DONE STOP QLA8 JOS END QCLAB FIOURE 13 JOB QCLAB IV ASS l-TV 3-ATC RAD-QCD LHT-QCM EXE IV.LMT *** INHERENT VISCOSITY *** ENTER BLANK DROP TINES (3) 226 8 226 7 ENTER SAMPLE ID ('DONE" AFTER LAST SAMPLE) MANUAL SAMPLE WEIGHT, DROP TIMES (2) 2017 273. 8 274 0 ENTER SAMPLE ID DONE STOP IV ("DONE* AFTER LAST SAMPLE) I END OCLAI 21134036 BFG10744 FIGURE 14 JOB QCLAB TS ASS 1-TY 3ATQ EXE TS.LMT RAD-QCD LMT-QCM INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS > ENTER DONE" AFTER LAST SAMPLE MANUAL INPUT WET. DRV AND PAN WEIGHTS FOR PAN 1 4 9430 1 3693 i 4263 INPUT WET. DRV AND PAN WEIGHTS FOR PAN 2 4. 8473 1. 3633 1 4280 INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE DONE STOP TS JOS END QCLAB 1 FIQURE 13 JOB OCLAB BEN ASS 1-TY 3-ATC RAD-QCD LMT-QCM EXE BEN.LMT BENNER FISH EYES INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE* AFTER LAST 8AMPLE INPUT BENNER FISH EYE COUNT FOR MANUAL 87 INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LA8T SAMPLE DOC STOP BEN JOB END OCLAB i BFG10746 s m wsTre FIQURE 16 JOB QCLAB FF ASS 1-TY 3-ATO EXE FF,LMT RAD-QCD LMT-OCM * * * FUNNEL FLOW #* INPUT SAMPLE IDENTIFICATION lUP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE MANUAL INPUT THE FUNNEL FLOW TIME FOR MANUAL 20 7 INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE DONE STOP FF UOB EM> SCLAB i 21134039 FIQURE 17 JOB QCLAB PUT ASS 1-TV 3-ATO RAD-QCD LMT-OCH EXE PMT.LMT * * * POWDER MIX TIME . * INPUT SAMPLE IDENTIFICATION (UP TO 16 CHARACTERS) ENTER "DONE" AFTER LAST SAMPLE MANUAL INPUT THE PONDER MIX TIME FOR MANUAL IN SECONDS 3 SO INPUT SAMPLE IDENTIFICATION (UP TO 14 CHARACTERS) ENTER "DOC" AFTER LA8T 9Af*LE DONE STOP PMT JOS END OCLAB O K im TZ