Document 2NdjeDQ5QBw82kjvBo1NKngzg
A R 7 0 6 -0 ^
Feces3MMPerMothtoEocdDoDIlCfeoAvreLlSoDtpumEdyPeAnNtRoM.TTeMt-Da6Eb3eNo1ril6Tvis.a,1mtC7iv,OSeTtsRu-.6Pd2yO9fSRo.A2r1PT,eETrf-Tl7uOIo3Xr2oI3oC;cOtSaLTnOe-4sG1ulYfonatc
FfSTelthcuuieosdsrysimtnOueedbtAyajebnicsoatlldiiyvteteeisc:iaganlnaeClydhsetiosm. gisetnryerTaeteamspteociumseenfsofrodretvheelo3pMmEenntvairnodnmvaelindtaaltiLonabaomraetothioyd of
Research Oient: 33SMMainSCtpPeenacuitaellr,t,yMBCNuhile5dm5in1igc4a42ls36Division
Sponsor:
33SMMainSCtpPeenacutiealr,l,tMyBCNuihl5de5min1ig4c4a2l3s6Division
Study Location: 33SMMainSCttPeranatuteelgr,,iMcBTNuoil5xd5iicn1og4lo42g7y0-L3aSb-o0r6artooroym SB314
Study Director:
AP33STMMhaoni.xdn:MiCrt6cePoe5wenal1dout-Mieg5clr,y7a.,Ml5BSSD-p3Neueae1ilpcc56dtai15i.atn1,l/igF4PsCAt42ho2XDr0p:-.o26rE5a1-t0e-72T3o3x-1ic7o7l3ogy
Study Toxicologist: P3DA3SMMhaedi:avn6nMCat5nnPee1acnade-Lut7ideclu3r,aR,e7MlBb-eD1ksNu3eeeialpr75d,rt45ci.Mn1hF/g4SACT42Xoo2xr:0pi-c6o2o5rEla1o-t-ge07i23Ts3to-x1i7c7o3logy
ProposeIInnd--SLLtiuiffdeeyESTtnaidmrtDeDlainatetee:::WMeodnndeasdyaNyoNvoevmebmebr e2r22,149, 919999
RTpTrhoeoigxstiuocsclotaoultoldogayrynywdLCilcaollbabmsGespipLlfieiaPerndfPocarreoms:gaerda"mCinlaPtshrsoeBc3eMdSuturSedt.yra"teagsiecxTploaxiniceodloingyTLOaXboSrOatPor0y9u5n0d, eSrtraadteegfiinced
004343
T-6316.17; T-6295.21; T-7132.3; ST-41
DfTuarennsitHsMhaekadetehsr,igiPahrl-:opduuricttyRNe-sEptoFnOsiSbEili,tyPFLOiaSisoannd3MPFOChSeAmtiocatlhseDSivtriasitoeng,ichTasopxriecvoiloougyslyLab.
IdentifiNcaatmioen::
NPp2e7F-r9EOf5ltSuF-3o:O9rPoS-e3oErcf:ltuaNnoaerrosruoolcwftoanRnaeamnSgiudelofNoen-tEhicathnAyoclli,dF, MPo-t3a9s2si3u.m Salt; CAS #
PFOSA: Periluorooctanesulfonamide
MolecularNFo-ErmtFuOlaS:E: C8F17S02N(CH2CH3)CH2CH20H PFOS: CsFitOSOj-KT PFOSA: Cdri7S02NH2
Lot NumbeNPornF-:eEOtsSFa:mOLSpolEet.:#L2o1t7s 30035, 30037, 30039 mixed and analyzed as PFOSA: L-10009
Purity:
PNPanFFdEOOA9tDSFS9nSA%O:aCl:Sy>pstE9uei9sc:re%hb9ny(83iaGq)%s.uCdeaMesst(eSd1rme)d.teeinrtemerdminbieynde1db9Fyt-hGNaCMt t,hRGe(Cs2t/)aM.riSng,
19F-NMR, 'H-NMR material was over
iHp9bQcCtmCfc(mhrIohp6rios9Puoaa*namFpoman%LntFicup1nloct3Ce9irorh)httSm6in(o,ha/tfe5)HOMi1tpteePer)ia8cySavt2.sFSnhsoN.tl,0e7iiOydmn2otbH%cahlgNSnr0hnpbe2als.,a,HedoCn2rprao16sc8t2Faquinr,,,hf%tc16iu3rcia)s1toi00a(h,etel,Cn0yn(0)2r3vC',itHF0w.zepop1i5Ft0ra2p1paf/a%a3t)1m.tmtpsi)l9x2ihoF3vpo6-%CCeno-Coemt5Nhx-PffoFc.((C8FeFMCCoCof(r%2C^Omtf7FFhaFRxwCF2S3mpe+C)g3Hc5)Aox1PiF2SFr-Msd-SSoFC1OiC3se5tsO0OHCai(sF2FsoCm.2N-FS-z2n(B-i(FSCNpHA2nNaCaO2ll)tFe2HHesFy)sr,2e3xgewa-2N2j5dS)-rsm,)(-1oSaHux0t2Sotp0-u0l-2i24Bnt0lSol2s-epd,a2nNu0t0-ptnhr-Nbht20eNmaHydee-a0vnHlNH2tlseaaobop2uwalHp2(rpwyfmlIap(eems2n(NneridrAtosocreeoohx9lfrrrpdeXfni,tmm6hehva40raeealai)0avlt.leeelddy
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T-6316.17; T-6295.21; T-7132.3; ST-41
tITCSShntetehfoasoatbrtrearmmiaslgitcaaetytmtteieC:orrainDiotasen)tooridiwnccaiuslitslm:iwylonbeniltnelsht:besatsetoiioskrenemdpwetttiiohlglnohbdtfelsiyl,eksc.eeopamtleopdnoasfititlireoo.nomortoemthperercahtuarrea.cteristics that define Animals:
IWNASSSdpotguereeuemanicrgitacinibehetf:esit:GGGGic:rnaaRRRRaitttnOOOOiiioandUUUUntiits:SRHPPPPoieaupnaxa342t1nrtri::.::alooiaqgPNcPfnnuuoFFt-eernoEOOe1ttftara2SDStoitFrA,lmmaleO,nwma,ae=nStnilan=eem3=Erys3tk3:,enn=t:3 a9p-1p1rowxiemekastely 200-250g Husbandry:
DEHnioevuti/srWionntEtoHTAagahelmfne:tmallrelorkvoreorrwpilua:raanoegondttmrfsnh:,aoTmowtMraueueiickralrtneolldtpatlbhoialdeseeelforcLci7nsthnioMt2,ooudnWndiu-tv4yrroioI38.da,fl5unsauFadnMfr,loildahnyrouet1hutamh2aopseneiuhdw/dsaoRientafuyadeitrmtecoilrenSiafgswltw3.ehri0rotlii/l-rlod7eibzma0ebar%bkopwltr,cetioolyaDlvmcmbilideeemie.tn,sdieemstttuaoutpbomapollmlliioesramdfaint1bsc0tyaaaiegHndxeaclasirhbltaaiotnnugmes Dose anMdeDthoosiduvmseAran1eoaos0golsgcilcll0iniufe/PhndrmgimamagsrvsdtLolaeaewsgemcm)/a1woiek1lai5pdlfgs0nin-lluib50elidmndserbgmmiotePlsrpelsstFealgeid:edstOd/r4riskofooao0ouSgswfsn0reeiPm(d/ndn2mgDFog-e%vrusOgoidisenpa/;suSkdwoe2isoAgenp0firprt.deaP.thrmhnloFeUe5sgsgRpOienaos/saemSivyntofr-raroasoLfa/igurntNnk)mkiesgodewpg-eosnEserinbfualn:otloostsdFfsbrpdiatoOeeiyhdynnnoeSpwzsgsorEtieieeironf,sropinPgogsruasu.ahFrpoettoeOs.f4dgftSiRNhrniwineanag-inlE2tdsrlsdot%etruirueNFndpcpTOy-geeEw3risSuvotteEsFeweuie!Onpina(lbg8lS2se8%raEife0nwoc;grei8elliel0ve
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T-6316.17; T-6295.2I; T-7132.3; ST-41
gTbPfraAoecayFwcrevsmOpeetianoiueSgivgnnmneeAlegep8t,2o(a0i5%2n2n.%r%gmaeTttm;lhsTw/2euwiek0nleesegmgmineobrnguno8o/l0u8dmsin0piyaoL.n2nw1)d%Rtoewhei1ngrTi-lowshldwuutabislegydelpehorzenpesnetrche8erseoepi0oioavsoftnreoyveforadetiahnfhmbfPegiicyneFislxaetOdiutlmiuwdSscrmsyoiAelo.lnelobTsvcdfoeeiiwnal1niatgo%dtedrsliaomynatwfibciaontieechlniltfeseoobottneorreferaenep1/ted2ds%e,o%rwvtsfhoiiinaelrlgnmo.readl Observation o fAnimals:
BColidnyicWaEEifolmibenaOaismccdgebhhihernsvdataegsennirsa:divimtwm.ealiataylilllopwbwnreisiillo:lrlerbbcteeoowordebeuesidtgeh.rhavAenedaddsdiimdaita.imiolynedaflioafrtienmldyoinprtgraisoliwrtytiolalnbtrdeemaretmocroebrniddteiatdynadasntdhenyotaarbele FrequeOrnecmnyeaacinnoidnntgrNoaulnmaimnbdaelosrnwoefilPAlFbnOeimSsaAaclrsri:afitcwedillobnedsaayc2ri-fpicoesdt odnosdea. y 1 post dose. All Specimen Collection & Analysis: MethodwUAaownfoinradlitilftnhmebtSeerwaepaauloersnnrecidwdpncimooeitflhesrlecdtcebnoeedfelsdoilCneewsfacueoolit.tllirhlvloeaTeboncnalehtucaiiezocmhpeonipndeal:alnieotbriiacmayfttluueaCvrdsl.iOonwflr2euoilamwmlnbeidleelogabwfcreouharsrsemishnceneeodterawcdwbrieoolidltlphi.bssem5yD-rp1eaceic0alroygfmroefdrelomecddneee,siddotwa.hnyDeiezsisuegoirdhdninteesg
rtEftanwasa5ererennleaaommiimpadcqlnczllarupohisyecobnrfveosnaepeeusirettnsersatieadw.nertyrtrleasull,iialaEd.oflribnslbuqewTaatldbegu,oocmheleeiahoesdedbdpntdudolllsndtisoaeorepv(iegeottroewdrhudcadrol6elmiiyfwlgnoacolpcmettoiatwrrlnlh-flootllml7o.i)epetbl20rnlAwcyewe0abttlb0iieaiCeselolpe0lnbmxlnteebocbfdrxaroateileimiulsivnogrltecbseisdismdodpctefeaoeleruosaeclnodrennttfrwarfaiceeduoil1dbtynmidgen5towosthdeooiwtlt(oseoiovatvt2uinueapegil3tbnaapahiaa0nabdelrnetninohedqamaayttlxehl.unieycciriedodTmaneseotbimuhnoafss1adrte,.ttgt.eaorho5etuislirzTemlfnilaymvuearaihninnegntf3nlesrgoetramif.orgwnrleraeBorierbatmidacrmldliomrler1ooaoyrdbb1coitsfnhela0idu)tocedo0gfwaeosmleen.xaadairdlsmitlcwgOhucabpebinfllelleolleessrs. lbsiaqecusriitdfoicrneeidtdroaogtne-7dn0afyoCr2-ffpuootrusbrteiodbcoihsoeecmhweiicmllailbcaeanleaaxlnycasisilsye.sdiK,s.wideniegyhsefdroamndafnlaimshaflsrozen in
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T-6316.17; T-6295.21; T-7132.3; ST-41
SpecimAtaeennlmal lHupyrosaiirnnsae,drtilahliynnedsgset:foesrcaeemdspaaltned-s7wt0hielCl sbeienruptmhaecakSnetddralitinevgedirrcyfoTircoemxaiecntodalbosoghlyiiptLepaeabdnoatlroya:stoisryw.illFboer
K3T9SM3ter.5ilsePEpBaHnhuuavols,ninhrMsoeeAnNnNmv,oeP5e.n:hn5u.6t1Dea53l.31T--37e3c7h38n1-6o0lo8g1y,
and Safety Services Facsimile No.: 651-778-6176.
twAhilelllkSbitderansteteoygrisecpdeTacoitmx-i7ec0noslCoag.nydltahbefroermbaioinchdeemr oicfaslearunmalyasnisd. liTvheersweisllpbeecikmeepntsin
Tfohlleownusm: ber, type, and date ofspecimens to be generated for analysis are as
TABLE 1 -Spea mensfo r EnvironmentalLab
S pecim en
C ollect o n d a te
Day 1 post dose Day 2 post dose
Environm ental Lab Specim ens
Urine Feces
12 12
10 10
Sera 2
10
Liver 2
10
Strategic Tax. Lab Specim ens
Sera Liver
2 2
10 10
Kidneys
10
Total 22 22 12 12 12 12 10
Data Analysis: All results will be provided for inclusion in the final report.
Responsibilities: tDcioseslaluenecntsainpLgecuiinemb-lekifneesrsfaponerdcaiAmnaneldynrssei,swp. eSrfeoarcmatinwgiltlhbeenreecsrpoopnssieibsleanfdorcdoollseicntgintgheanadnismenaldsi,ng ArenvdierwewbeSfeoarceaat wfinilalldrreapftoartfiisnaislsrueepdo.rt and ensure the report receives appropriate 3M
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Signatures:
Hi).
DSSetru.ndiAoyrnDdRriereeswecatSorcrehacTaot xicologist
ADStdeuavdnaynnTcaeoJd.xLTicuooexlobicgkoieslrot, gMisSt
T-6316.17; T-6295.21; T-7132.3; ST-41
Date Date
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T-6316.17; T-6295.21; T-7132.3; ST-41
References: 1. PayfT8e1wr6,o,R6Y/C2e3ah/ra9Fr7ae.cet3deMirnizgSatSMiotuDndyoL.faFbSMMB-uD3d9dA2in3ng,alM2y3tii6xcat-u2lrBRe-eo1qf1u.Leostts#5320408395., 3A0n0a3l7yt&ica3l0R0e3p9ofrotr# 2. KesLStnpaeber,cotTrrao.tsoFcrloyupo/yrSoRcMheMeqmuDeics-ta2l#3I65s-o23mB03e-1r01D.3, iMDsterSicbepumetciboiaenlrtby1y,A11d99Fh9-e7Ns.iMveRs &SpCechtermosiccoaplsyA. nalytical 3. Payf5e9r4, 2R6.GRCe/pMorSt 9an/2a4ly/9si9s.o3fMPFSOAS&AC(LLa-1b0B00u9il)d.inSgA2&36C-2ABn-a1l1y.tical Request No. 4. KLSapebestocntrreaort,socTroy.p/CyShRMemeMqiucDaels-t2C#3h6a5-r92aB4ct2-e16r1i.z3,aMStieopSntpeoemcfbiPaeFlrtOy2SA5A,d1h,9Le9s-i91v.0e0s0&9,Cbhyem1HicaanlsdA1n9aFly-tNicMalR
5. CDC15hoe8rRro4po.mooRrasaettFoqeg.uArCeanshptaahl#ryyatAciGct-aer1olr5iuTz1pae2.tc5iho4nn.ooRlofegPpyFoCOrteSn1At0e/Sr7,a/B9m9up,illaednsind, gTL-2e70t1t1e3-r21a--1d2d9(e,LnC-d1Au0mT00Ct9o-) raenpdoTrtN1-0A/1-4/99.
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