Document 2NaB5bjqzEDv6JVbrBE0Ld17L

[ames | | | | | 294002D.4Da5a1y6:GavvSaiggbeeShStrodynyiiiTnoRRaxttis cwvithOneGGeenenraetoionRReepprroodduuccttiioonnEvavluaatinonss ARR2E_ 3238 DDRueurvrioosmen-d35P3a8kge TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats `with One-Generation Reproduction Evaluations Revision No. 1 Volume 5 of 5 TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) AUTHOR: Gregory S. Ladics, Ph.D, D.A.B.T. ORIGINAL COMPLETED ON: December 3, 2001 REVISION NO. 1 COMPLETED ON: April 5, 2002 PERFORMING LABORATORY: E.I du Pont de Nemours and`Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 wok Reaves Novae (ID) service Cove Nuvser {J ronson suo Novos{END) TT heme LT ---- ------ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5386 APPENDIX MM INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Py ADULTS AND Fy ADULTS SompanySanftized. Does not contain TSCA CBI E32 H9-02-4D5a1y6:GaSvuabgeehrSotnuidcy TinoxRiactistywithOne:Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY FINAL BODY AND ABSOLUTE ORGAN GROUP: 1-0 0 mg/kg/day ANUNMIBMEARL. FBIoNpAYL THGYLRAONIDD s64a33212498 551781..86 00..001196 s6a433221087 65342..96 00..002233 664433228101 652971..70 00002271 664433129472 661252..38 00.002242 664433124571 568123.32 00..001280 664433227564 75569..83 0o.l0o2t3a AND ORGAN WEIGHTS WEIGHTS (grams) FROM P, ADULTS MALE RATS CompanySentized. Does not contain TSCA CBI 5 H9-02-4D5a1y6G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANTMAL FINAL BODY FINAL BODY AND ABSOLUTE ORGAN GROUP: IT1-0 25 mg/kg/day ANNIUMMBAELR FBIoNDAYL THYGRLOAINDD 664433210878 560808..59 00.002116 664433213700 6514940132 00..001167 664433124707 658109.088 00..001289 64433211646 661252.67 00..001280 664433115737 55983197.9 00001136 664433219617 661375..18 o0l0o2137 664433222333 55328192.0 00.002230 664433128139 662485..49 00..002206 643263 5395 0.019 AND ORGAN WEIGHTS WEIGHTS (grams) FROM P. ADULTS MALE RATS CompanySanitized. Does notcontain TSCA CBI 28 9204-5D1a6y:GaSvuabgcehrSotnuidcy TinoxRiacistywithOne-Generation Reproductive Evaluations Dupont-5386 INDIVIDUAL ANIMAL FINAL BODY FINAL BODY AND ABSOLUTE ORGAN GROUP: V-0 100 mg/kg/day ANUNMTBAELR FBIoNDAL THGYLRAONIDD 664433311435 625449..48 00..002268 664433311929 555644..91 00..001222 664433224156 505515..80 00..002138 664433320010 66106..84 00..001284 664433125378 650335..94 00.002370 664433116540 643590..83 00.001290 664433129008 45265142.9 00001283 AND ORGAN WEIGHTS WEIGHTS (grams) FROM P, ADULTS MALE RATS Company Saniized. Doesnotcontain TSCA CBY 1285 0H--2D4a51y6:GaSvuabgeehrSotnudiyc TinoxRiactistywith One Generation Reproductive Evaluations Dupont-5386 INDIVIDUAL ANIMAL FINAL BODY FINAL BODY AND ABSOLUTE ORGAN GROUP: VII-0 250 mg/kg/day ANNUIMMBAELR FBNOADLY THGYLRAONIDD 664433218791 624586..20 00..002278 sa6433125089 658339079 00..004134 664433126418 548077.78 00..001380 664433228754 59287.33 00..002146 664433129222 65183235 00..002255 654433116901 550491.50 00..001284 664433330127 59477.a9 00..002350 AND ORGAN WEIGHTS WEIGHTS (grams) FROM P, ADULTS MALE RATS CompanySanitized. Doesnotcontain TSCACBI --_-- 910.-24D5a1y6G:avSaugbcehSrtoundiyc iTnoxRiacittsywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANTAL FINAL BODY AND ORGAN WEIGHTS - FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM GROUP: IT-0 ma/ka/day ANNUDMMBAELR FBIoNDAYL THYGRLOAINDD 664433448509 664433326231 664433440119 664433347585 664433444778 643386 337370.88 00.001199 328769.13 00..001174 3022490 00..002106 337361178 00..002274 336359.191 00..002132 3543 0.021 P; ADULTS FEMALE RATS Company Sanitized. Does notcontain TSCA CBI 287 -- H-24516: Subchronic Toxicity 90-Day Gavage Study in Ras with One-Generation Reproductive Evaluations DuPont5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM GROUP: 1V-0 25 ma/ka/day 664433333949 334525..40 00..002211 664433436609 339717095 00..002146 664433439402 33583178 00..002202 64433443188 34365.240 00..002197 64433342759 351065..67 00002217 64sa333a7s6z 363765.090 o0l.o012s0 664433437752 3384860.97 0ol0o2t2s 645433430905 353560.005 00l.002166 643457 ami 0.023 Py ADULTS FEMALE RATS Company Senitized.DoesnotcontainTSCACBI 3 -- 9102-4D5a1y6;GaSvuabgcehrSotnuidyc TinoxRiactistywith One-Generation Reproductive Evaluations Dupont 5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM GROUP: VI-0 100 mg/ka/day NAuNMIBMEARL FIBNoAnLt THYGRLOIaD 664433342208 336870.68 00..001198 664433433593 363603.00 00.002241 664433333379 338813000 00..001176 664433441267 3324910s2 00.001264 646433348394 363650.028 00..001286 646433343630 334660..80 00..00215 P, ADULTS FEMALE RATS `Company Sanitizsd. DoesnotcontainTSCA CBY Ee H9-02-4D5a1y6:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 INDIVIDUAL ANTAL FINAL BODY AND ORGAN WEIGHTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM GROUP: VIII-0 250 mg/kg/day ANnUIMHBAELR FBIONDAYL THGYLRAONIDD 564433446473 321559.043 00..002153 664433441173 263036..64 00.001238 664433333385 363527..46 00..002168 sa6433u464s0 3931090063 00..002274 646433336256 3368100055 00.002254 66443343028 331727014 00..001199 P, ADULTS FEMALE RATS Company Sanitized. Does not contain TSCA CBI 290 _ g 5 5 3833353888838 8 1B!g 1 n Aeaag iAnia ias f BE 31 srasnsssaasss i jf EEE _ i|e zdg8 ZEEEImuEEEREIEIREEEERSEE 5 3d2i.g 8g| ssasasassasas - g i i gl Secsssssssses BHrEeR 7 aasemusaseens jie = {282 5 smmmmegennane $ RESELLER EERE] 23 3 i E 3F cdenE dsiiadd 1% 189 speesezessees | ; 3 Hema ~iF Tf i i - PBEy op sadmdennieamdsinsininieina C3 g FIRTEREREBRPERE -- gi i saiaiaiiiazazize jap F180 2 5 BF EEEEEEEREEE fg39435%53eagenss Z ANAARAAN Ramo ao. ii Fid. ocaSEHSnBREGNEREESTEEIERNEE ~3 8 8 g 3 3 i o 5 - 2 8 LE: todp gBp EmeRseEssEmnEenRs 5 BIg .ooii eefsmneamaaEaer 8p oz3zasssaaaas gi s3easdsidass 5 EF ereies ; ie. 85 B3gsmssEiEa al & 3 E Sosss0ses0es ER Hof fois HER fiz I. 3R4385833888 8 Gunsdddsdiad 38 rH EEE Ho EE 7 3% gzeesszsssnzs 2 id smn ~i 8 =3 : s3pasRiniage By OB ESNIEEEE fg : #3 sEpaansAnEenReEeEeRs - | g : fEIaEEsEann I Fe H5s 4i; gd saEiEIEEEE op oarssnesazas: g adadddadiiad i 3 5S2FsEgREIse 3 3 gaasadassddes F2E2 IE Pa r sta i 2 - g 8% sannzssasass --- 38 8 8 & g 3 ] : aE z g:Eg ii EpgE ogFUmmEmaImEmsRmEaaRn Z3 Eg 2 yssgeserasany ~~ gg ;g " coccccccccccs 3) i. Hiil HEi i Hoe g3 sss8sEsssssis cooceoseseese femme 5 24g gasassasnsess : E 5 daddadgananis EI 53 2 gf S3NoEaRmReAnRaRsEsRnReEsR 3 - 22 } 2 i i ERRgsE3388Rse 355 s; i SERRE 25 g z 2 3 ;i i5 "3 g ~3 ; z : g a3 2 ed i ' il 2 ssmmsssseszsserss jgEZE SEURRm REgREIm ZRfLE: ~ iegEgE3SEaiSgIEsRINSES GEEEES 5 51 g285 31 oie Bl Ze dgF:i: 2HI z2 i iy ogiox i5Hi3i5e3n5a r5e3n8a3m n38s3n3am 3n8s3a2s | EaENEER BL3RSR2ILANRREES pr smmmonng 3 ddsdindegigdsndy m 2 4p eecs ennneen saneun i 3 8583225030808285Y ~3 i gs2 i I gf0 BE A2RAaZtIaPRSAARSEERREER 3: so sasesareszex |e EEEEEEEEEEE EE] deff SEER gag BE 2 22 2 23gnsssegsar %1 1 soesmmmnmeer g g Co CeesdddEgred 2 g I 3H8 zpasasannzanssaas : 2 i i 3 i 5 ~ ~ 3B 8 2 i 38 gE 5 apessresgase id Boman 3. irssuncesEn cE 2 353383535380 --- z BE veceeccocsee 2 g 53 > 1H1dERE 4a, Gf GGanicEEm 5! i g rms f| i:7, RfT anaa 82 32 comm 5 Iu mann EE 30 sszsesvenses ~i i 01.-2D4a5y16G:avSaugbcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 APPENDIX NN INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS Company Sanitized. Doesnotcontain TSCACBY 2% H9-02.4D5a1y6:GavSaugbeehSrtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS ~ P; ADULTS EXPLANATORY NOTES Abbreviations AFDK == AFcocuinddendteaaldly killed SD = Sacrificed by design DuPont-5386 Company Sanilized. Does not contain TSCA CBI 1300 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTMAL GROSS AND HICROSCOPIC OBSERVATIONS - 2, ADULTS FALE RATS GROUP: 1-0 DOSE: ng/ka/day ANDOAL 8: 643147 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: NSoENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. --_--mm eo oro Company Sanitized. Does not contain TSCA CBI 9H:02D4a51y6:GSgubchSrtoundiyc TinoxRiuctistywith OneGeneration Reproductive Evaluators Dupont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS NALS RTS GROUP: 1-0 DOSE: O ma/ka/day ANINAL 8: 643148 Davs on TEST: 107 HoDE OF DEATH: 5D GROSS OBSERVATIONS: NoNE WICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNRENARKASLE NICROSCOPICALLY: NONE ITCHSROFSOCLOLPOIWCINGEXTAIMISNSAUTSISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE HORSGANNoFwOeNLOLTOWICNOGUNTTEIDSSUTENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE, sSoEnCeTIONS OF THE FOLLOVING TISSUSS WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACNToIIwNOsANTSIOONF;THOREGAFNOLLNOOWTINCGOUTNITESDSUSISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC - 4 NGnaoectregocrpotsseysd. owbhseHenowrevtvaheteris,oensbTriowstseourceeoslenwtetreiersesdurees-ienwxtaeomrietnheesda:dveadtabaansdenoatabthneormtailmietioefs were -- we `Company Sanitized. Doesnotcontain TSCA H-24516: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS ALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL 8: 643155 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNES.LATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,NICROSCOPICALLY: COAGULATING GLAND, TESTES TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `NORE. SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: "= SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. "ompany Sanitized. DoesnotcontainTSCACBI 08 0H--2D4a51y6:GavSaugbeehSrtoundiyc iTnoxRiactistywith One Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: 1-0 DOSE: mg/kg/day ANIMAL 8: 643163 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOVLULIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEWVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLAND, TESTES MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: -~ ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTIACBILEESNT FOR MICROSCOPIC NONE. CompanySanitized. Doss not contain TSCA CBY 508 H24516: Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANDHAL 8: 643176 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIOSW,INGPROTSITSASTUEE,S WSEERMEINAULNRVEEMSAIRCKLAEBSL.E NICROSCOPICALLY: COAGULATING GLAND, TESTIS TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE nSoEnCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: - SEXEACMTNIIONONANETSIOONF:THOERGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Company Sanitized. Dass not contain TSCA CBI 1305 -- 9H-02-4D5a1y6:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS ALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANDIAL : 643196 DAYS ON TEST: 108 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MIPCRROOSSTCAOTPEIC OBSERVATIONS: - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL ETPHIEDIFDOYLMLIOSW,INGSETMIISNSALUESVESWIECRLEESU,NRTEEMSATRIKSABLE MICROSCOPICALLY: COAGULATING GLAND, MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ~ SEEXCATMIIONNATSIOONF:THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC NONE Sompany Sanitized. Doss not contain TSCA CBI 3 H9-02-4D5a1y6G:aSvuabgeehrSotnudiyc TinoxRiactistwyith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS ALE RATS GRov?: 1-0 DOSE: 0 mg/kg/day ANIMAL : 643197 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC _ NONE ompanySanitized. Does not contain TSCA CBT 07 ~ 9204-5D1a6y:GaSvuabgeehrSotnuidyc TinoxRicaittsywith OneGeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS = P, ADULTS HALE RATS GROUP: 1-0 DOSE: 0 mo/ka/day ANIMAL 8: 643207 DAYS oN TEST: 108 HODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUSS WERE UNREMARKABLE NICROSCOPICALLY: NONE NTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; NICROSCOPIC DIAGNOSES NOT MADE, NONE: NSoEeC,TIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ None SompanySaniized. Dos not contain TSCA CBI 1308 S204-5D1ay6:GaSvuabgcehrSotundiyc iTnorRiacsitwyithOneGeneration Reproductive Evaluations Dupont 5386 - TNDIVIDUA, ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS ALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANAL 8: 63211 DAYS oN TEST: 109 ODE OF DEATH: SD GMRIOCSRNSOOSCOABOBSPNEIORCRVMACATOLIIROTRNIESEL:SATEDET(EsCeTlEeDcted lesions) NICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNRENARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCI.NGEXATMIISNSAUTEISON:WER=ENOANUETOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, on NSoEwCeT,IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUNTTIESSDUEISN None. WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - Company Sanitized. DoesnotcontainTSCACBI 505 H9-02.4D5a1y6:GavSaubgcehSrtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS AND WICROSCOPIC OBSERVATIONS - 2; ADULTS MALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL : 643216 DAYS ON TEST: 108 NODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESAUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. Company Sanitized. Doss notcontainTSCA CBI ED 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generution Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P: ADULTS MALE RATS GROUP: 1-0 DOSE: 0 m/kg/day ANIMAL 8: 643229 DAYS ON TEST: 107 MODE OF DEATH: SD GWRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. Company Sanitized. Doesnotcontain TSCACBI Bi 910..24D5a1y6G:avSaugbcehrSotnuidcy iTnoxRiactistywith One-Generation Reproductive Exaluaions DuPont5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS ALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANIMAL 8: 643239 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIOSW,INGPROTSITSASTUEE,S WSEERMEINAULNRVEEMSAIRCKLAEBSL,E WICROSCOPICALLY: COAGULATING GLAND, TESTIS MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: . SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. CompanySanilized.Doesnotcontain TSCACBI B12 -- H9-02D4a5y16G:avSaubgeehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations Dupont5386 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DAL +: 643202 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSoEnCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF: TOHREGAFNOLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Company Sanitized. Doss notcontainTSCACBY - ww 9H0--2D45a1y6G:avSaugbcehSrtoundiyc TinoxRiactistywithOne.Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: 1-0 DOSE: 0 na/ka/day ANIMAL 8: 643251 DAYS ON TEST: 109 NODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNEONCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE. Company Sanitized. Dossnotcontain TSCACEY --_--_-- 910.:24D5a1y6G:avSaugbcehrSotnuidcy iTnosRicaistywith One-Generation Reproductive Evaluations Dupont. 5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS WALE RATS GROUP: 1-0 DOSE: 0 mo/ka/day ANIMAL #: 643254 DAYS on TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOINCINGEXTAIMISNSAUTEISONW:ERENOANVIEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRISDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: oSEuCTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITESDSUEIS WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- Nowe. - `Company Sanitized.Doos notcontalnTSCACBI ws H9-02-4D5a1y6G:aSvuabgeehrSotnudiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPone 5386 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P: ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL 8: 643270 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR WICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF;TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE CompanySaniized.DoesnotcontainTSCACEY Te 91.02-4D5a1y6:GaSvuabgeehrSotnuidcy iTnoxRiacittywithOneGeneration Reproductive Evaluations DuPon5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643271 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEPHIEDIFDOYLMLIODWEISN,G TPRIOSSSTUAETSE,WERSEEIUNNARLEMAVERSKIACBLLEES,MICROSCOPICALLY: CORGULATING GLAND, meses KTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE T`OHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, None: HSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Nowe. - Company Sanitized.DossnotcontainTSCACB wn -- H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont-5386 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Group: 1-0 DOSE: mg/kg/day ANIMAL 8: 643276 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE `TOHREGAFNONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `None HSoEnCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE `Company Sanltized.Dossnotcontain TSCA CBI EO H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grove: 1-0 DOSE: mg/kg/day ANDHAL : 643280 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION. ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE ompany Sanitizod. Doesnotcontain TSCACBI To H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with OnGeeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS FALE RATS Grove: 1-0 DOSE: 0 mg/kg/day ANDOAL 8: 643284 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNES.LATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPIEDIFDOYLMLIOSW,INGPROTSITSASTUEE,S WSEERMEINAULNRVEEMSAIRCKLAEBSL,E NICROSCOPICALLY: COAGULATING GLAND, TESTIS MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: "= ESXEACMTNIIONONANETSIOONF;THOERGAFNOLNLOOTWINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC `ompany Sanitizad. DoesnotcontainTSCA CBY ED 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRicaittsywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grove: TrI-0 DOSE: 25 mg/kg/day ANIMAL #: 643144 DAYS ON TEST: 107 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - sompany SaniDtoeisnzotecondta.in TscACBl [1] H9-02-4D5a1y6G:avSaubgeehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont 5386 -_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: TTI-0 DOSE: 25 mg/kg/day ANIMAL B: 643153 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE - Company Sanlized. Doesnotcontain TSCA CBI 2 01-24D5a1y6:GavSaugbcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS HALE RATS Group: 111-0 DOSE: 25 mg/kg/day ANIMAL 8: 643166 DAYS ON TEST: 108 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `None NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE: Company Sanitized. Doesnotcontain TSCA Cal 5 9102-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistwyithOne-Generation Reproductive Evaluations Dupon-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: 111-0 Dose: 25 mg/kg/day ANIMAL : 643167 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE. NONE SNoExCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE - Company `Sanitized.Sanitized,Dno ot cos ntainTSCACBI es 1.24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaion Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Group: 111-0 DOSE: 25 mg/kg/day ANIMAL #: 643170 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC -- NONE. CompanySanitized. Doesnotcontain TSCA CBI 25 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generaton Reproductive Evaluations Dupon-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: 111-0 DOSE: 25 mg/kg/day ANIMAL 8: 643177 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC _ NONE. - CompanySanitized.Doesnotcontain TSCACBY 26 -- 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5386 -_ INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: III-0 DOSE: 25 ma/ka/day ANIMAL #: 643183 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNBSL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF: TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE Company Sanitized. Does notcontain TSCACBU T27 -- 910.-24D5a1y6G:avSaugbcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - B; ADULTS MALE RATS GROUP: III-0 DOSE: 25 mg/ka/day ANIMAL 8: 643184 DAYS ON TEST: 109 ODE OF DEATH: SD `MGIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLULIODWEISN,G TPIRSOSSTUAETSE,WERSEEMIUNNARLEMAVERSKIACBLLEES,NICROSCOPICALLY: COAGULATING GLAND, TESTES MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET,IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: "~ ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE - Company Sanilized. Does not contain TSCACEY 3 -- 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generaion Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS Group: 111-0 Dose: 25 mg/kg/day ANIMAL 0: 643188 DAYS ON TEST: 107 NODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESLATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNOENCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NoNE Company Saniized. Does notcontainTSCA CBY 2 - 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiaciistywith One-Generaion Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- Py ADULTS MALE RATS GROUP: 111-0 DOSE: 25 mg/kg/day ANIMAL 8: 643198 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEPHIEDIFDOYLNLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMIUNNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLAND, `TESTES MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: "= ESXEACMTNIIONONANETSIOONF:TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC CompanySanitized.Doesnotcontain TSCA CB1 ~ 530 9H0-2-4D5a1y6:GaSvuabgcehrStudoy niicnToxRiactistywith One-Generaton Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS ALE RATS Group: 111-0 DOSE: 25 mg/kg/day ANDNAL 8: 643214 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHISCROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC = NONE. Sompany Sanitized. DoesnotcontainTSCACB 1 9H:02D4a51y6:GavSaugbcehSrtoundiyc iTnoxRiactistywithOne Generation Reproductive Evaluations Dupont5386 - INDIVIDUAL ANIAL GROSS AND MICROSCOPIC OBSERVATIONS - By ADULTS ALE RATS GROUP: ITI-0 DOSE: 25 mg/kg/day ANIMAL #: 643219 DAYS on TEST: 109 NODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TNHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, Rowe: SNoEwCeT.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF: TOHREGAFNOLNLOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --- None. `Company Santized.DoesnotcontainTSCATEY _-- 9H0--24D5a1y6G:avSaugbcehSrotnuidcy iTnoxRicaittsywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANDIAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: TII-0 DOSE: 25 mg/ka/day ANDNAL 8: 643223 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION _ SEXEACMTNIIONONANETSIOONF;THOREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC Company Sanitized. Doesnotcontain TSCACBI --_ m-- m _--m 01.-2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRicaittsywithOneGeneration Reproductive Evaluations DuPont$386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Group: TII-0 DOSE: 25 mg/kg/day ANDHAL 8: 643230 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSOCBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC _ NONE. CompanySanitized. DoesnotcontTSaCAiCnBY Ta -- H-24516: Subchroric Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS ALE RATS GROUP: TII-0 DOSE: 25 na/ka/day ANDOAL 8: 643233 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. - `Company Sanitized. Does not contain TSCA CBI 3s - 19.02.4D5a1y6:GaSvuabgeehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: III-0 DOSE: 25 ma/kg/day ANIMAL 4: 643261 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIOSW,INGPROTSITSASTUEE,S WSEERISNAULNRVEEMSAIRCKLAEBSL,E WICROSCOPICALLY: COAGULATING GLAND, TESTIS MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNoEnCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION "= SEXEACMTIINOANTSIOONF: TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC ONE CompanySanitized.Doesnotcontain TSCACB! - wm 1502.4D5e1y6:GaSaugbeehrSotniyc TinoxRict withOneGeneration Reproductive Evasion Duron: 386 - CNDTVIDUAL VIRAL GROSS AND MICROSCOPIC OBSERVATIONS - 7, ADULTS WE ATS GRO: TXI-0 DOSE: 25 maka/day sims 6: 643263 oavs ow Test: 109 wove of mam: sD GVrioCsNRsOoSCoAOEnPNsIOECRvUAACTLOIIROTRNIESEE:SATEDET(AsCeTlEeDcted lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNWEARKASLE MICROSCOPICALLY: NON THCERoFSOeLoLROtUcINGBXTANITSRSNUEEISONW:ERENAOUNTEOLYZED; DEGREE OF AVTOLYSTS DID NOT PRECLUDE RTHeEoaFeOHLLoOWICNOGmTTEIDSSUTENSTWHECRDEENSCEEVETRAEBLLYESA.UTOLYZED; MICROSCOPIC DIAGNOSES NOT WADE, oSEvCeTIONS OF THE FOLLOWING TISSUES VERE NOT RESENT FOR MICROSCOPIC EXAMINATIONS _ ESXEACMToIInNOeANTSIOONF; THOERGAFNOLNLOOWTICNOGUNTTIESDS.UEIS WTEHRCEIOTRUCSEUFTFAIGCLIEESN:T FOR MICROSCOPIC - -- Company Sanilized. Doss notcontainTSCA CBY 24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5386 -_ INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P. ADULTS MALE RATS GROUP: III-0 DOSE: 25 mg/kg/day ANIMAL #: 643277 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TH FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF;THOREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC -- NONE. `CompanySanitized. Does not contain TSCA CBI TS -- 9102-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiatcslywith One-Generation Reproductive Evaluations DuPont 5386 --- INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P: ADULTS MALE RATS Grove: TII-0 DOSE: 25 mg/kg/day ANDHAL 8: 643287 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE NSOENCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION. SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Company Sanitized. Doesnotcontain TSCA CBY ED -- 0H--2D4a51y6:GavSaubgeehSrtoundiyc iTnoxRiacittywith OneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - B ADULTS NALS RATS GROUP: III-0 DOSE: 25 mg/kg/day ANDHAL 4: 643291 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA.UTOLYZED; WICROSCOPIC DIAGNOSES NOT MADE, NONE NSEoCnTeIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF: TOHREGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE `Company Sanitized. Does not contain TSCA CBY EJ H9-02.4D5a1y6G:aSvuabgeehrSotnudiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P. ADULTS MALE RATS Group: v-0 DOSE: 100 mg/kg/day. ANIMAL 643146 DAYS ON TEST: 107 NODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTEIDSSUIBNSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIIONANTSIOONF:THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. ~ompany Sanitized.Doesnotcontain TSCACBI a -- 2904-5D1ay6:GavSaugbcehSrtoundiyc TinoxRiactistywith One.Generation Reproductive Evaluations Dupont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P: ADULTS HALE RATS GROUP: V-0 DOSE: 100 ma/kg/day ano v: sansa DAYS oN TEST: 109 woe oF DEATH: 5D GWrIoCsRsOSCoOpPsIECRvACTOIRORNESL:ATE (selected lesions) No ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANNoFnONeLOLTOWCIONUGNTTIESDSUTESIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NSoEwCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF: THOERGAFNOLNLOOWTINCGOUTNITSESDUETSN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC _ Nong. - `Company Sanitized. Does notcontain TSCACB ee 2504D5a1y6GovSaugbechSrtonyi iTn Roaiith OeGeneration Reprodcive Evans Duron 86 - CADIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADVTS VALE RATS GROUP: V-0 DOSE: 100 ma/ka/day avo 4: 6anise oars ox mest: 103 wops oF oem: 5 rVEoCsRNsOoSCoAOsMTsIeMCmOuaCNnOiRIoRTnEsLEE:ASTEDET(EsCeTlEeDcted lesions): MICROSCOPIC OBSERVATIONS: NONE TSHTEDTIFeDOVeLMnLIaODVEISN,G TFIROSSSTUAETSE.WERSEEMUINNAFLEWVAERSKIACRLLEES.MICROSCOPICRLLY: COAGULATING GLAND, TTEHCEROFSOCLOLPOIWGI.NGEXTEIRSSTUIEOSNW:ERENOAWUTEOLYZED; DEGREE OF AVTOLYSIS DID NOT PRECLUDE RHoEaonFwOsNLoLrOVCINOGTTEISSSUTEhSTWHECRIEDENSCEEVEBRELLEYSA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT ADE, SSEoCeTIONS OF THE FOLLOMING TISSUES WERE NOT FRESENT FOR MICKOSCOPIC EXANINAFION -- SESCXoTIInAOeTNSIOONF: TOHREGAFNOLLNOOAINCGOUNTTIESDSUEIS WIENRCEIDEINNCSEUFTIACBILEENST FOR MICROSCOPIC - -- `Company Sanitized. Does notcontain TSCA CBI ww H9-02-4D5a1y6:GavSaugbeehSrtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont 5386 --- TNDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GRovR: v-0 DOSE: 100 mg/kg/day ANIMAL 7: 643157 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHISCROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNOENCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. ~ CompanySanitizad.Doesnotcontain TSCACB Ta 02-4D5a1y6:GavSaugbcehSrotnuidcy TinoxRicaittsywith One-Generation Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grove: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643164 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NoNE NSEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. `Company Saniized. Does not contain TSCATH Ts ~ -- 9H0--24D5a1y6G:aSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Group: v-0 DOSE: 100 mg/kg/day. ANIMAL #: 643182 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPIEDIFDOYLMLIOSW,INGPROTSITSASTUEE,S WSEERMEINAULNRVEEMSAIRCKLAEBSL,E WICROSCOPICALLY: COAGULATING GLAND, TESTIS MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION -- ESXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. "ompany Sanilized.Doesnotcontain TSCA CBI TS 51.02:4D5a1y6:GoSvuabgeehSrtoundyc iTnorRiacistywith OneGeneration Reproductive Evaluations Dupont5386 ~ INDIVIDUAL ANIYAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ADoAL 4: 643190 DAYS ON TEST: 109 HODE OF DEATH: SD GVRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) No ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AVTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; NICROSCOPIC DIAGNOSES NOT WADE, NONE: NSoEvCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --- NONE `Company Sanitized. Does notcontain TSCA BY ET 124516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day. ANIMAL #: 643199 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE O`TRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE. Company Sanitized. Does not contain TSCA CBI TE -- 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generaton Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day. ANDNAL 8: 643200 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. Company Sanitized. Does notcontain TSCACEE T55 H9-02-4D5a1y6:GaSvuabgeehrSotnuidyc TinoxRiactistwyith One-Generation Reproductive Evaluations Duponi-5386 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - B, ADULTS HALE RATS Group: v-0 DOSE: 100 mg/kg/day. ANIMAL 4: 643208 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL.ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE. sompany Sanitized. Doesnotcontain TSCACB! 50 H9-02-4D5a1y6:GavSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL 8: 643216 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTIESDSUIENS IWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE `ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC Pa NONE Sompany Sanitizad. Doesnot contain TSCA CBI 351 9H0-2-4D5a1y6:GavSaugbeehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day. ANIMAL 8: 643227 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLAND, `TESTES MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: - ESXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Company Sanilized. Doesnotcontain TSCA CBI EE H-24516: Subehronic 0-Day Gavage Study TinoxRiactistywith One-Generation Reproductive Evaluations Dupont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS ALE RATS Gop: v-0 DOSE: 100 mg/kg/day ANDHAL 8: 643238 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEEXCATMIIONANTSIOONF:THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE Company Sanitized. Doas not contain TSCA CBI 5 91.02:4D5a1y6:GoSuvbeetvSotnuidcy TinoxRiactistywith OneGeneration Reproducive Evalutions DuPont5386 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS = 2; ADULTS MALE RATS GROUP: V-0 DOSE: 100 ma/ks/day Avi +: 643200 oavs on Tes: 108 oDE OF DEATH: SD GNRIOCSRNOSO.SCOABOBSPNEIORCRVWACATOLIIROTRNIESEL:SATDEET(SsCeTlEeDcted lesions): MICRPORSOCSOTPAITCE OBSERVATIONS: - INFLAMMATION, SUBACUTE/CHRONIC, MINIWAL TEPHIEDIFDOYLNLIOSW,INGSETMIISNSAULESVESWIECRLEESU,NRTEEMSATRIKSABLE NICROSCOPICALLY: COAGULATING GLAND, MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNVETOLYZED; DEGRES OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANNoFnOeNLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NSoEwCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC none Company Senitized.Dossnotcontain TSCACal - = 012-4D5a1y6;GoSvuabgcerSotnuidcy TinoxRicsitywithOeGeneration Reproductive Evaluations Duponts386 - INDIVIDUAL ANTWAL GROSS AND MICROSCOPIC OBSERVATIONS - P. ADULTS ALE RATS GROUP: V-0 DOSE: 100 mg/ka/dey [rm Das on TEST: 208 ODE OF DEATH: SD MGrIoCsNRosO.SCoAORsPNsIOECRRUVACALOTTRIIROIENELS:SATEDET(EsCeTlEeDcted lesions:) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE VTHIECRFOOSLCLOONWCINGEXATMIISNSAUTEISONW:ER|ENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGoANFeONLLoOWCIONUGNTTEIDS.SUTENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. SSEoCvT.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXNMINATION _ SZEXCANTNoIInNOAeNTSIOONF; THOERGAFNOLRLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR WICROSCOPIC - Gompany Saritized. Dossnotcontain TSCATBY ee 91.02-4D5a1y6G:aSvuabgeehrSotnuidcyTionxRiactistywith One-Generation Reproductive Evaluations Dupont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: V=0 DOSE: 100 mg/kg/day ANTMAL 4: 643255 DAYS ON TEST: 109 KODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED HICROSCOPIC OBSERVATIONS: NONE ETPHIEDIFDOYLNLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLAND, TESTES TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE T`OHREGAFNONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESAUTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE, NONE NSoEwCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: "= SEXEACMTIINOANTSIOONF:THOREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE ompany Sanitized. Dossnotcontain TSCA CBI _ 56 - H9-02-4D5a1y6G:avSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS Grove: v0 DOSE: 100 ma/kg/day. ANIMAL 8: 643267 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIOSW,INGPROTSITSASTUEE,S WSEERMEINAULNRVEEMSAIRCKLAEBSL,E NICROSCOPICALLY: COAGULATING GLAND, TESTIS MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NOE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: - SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Sompany Sanitized. Does notcontain TSCA CBI 57 90Day Gava age Sy n Rats with OneGeneration Reproductive Evasion DuPonts386 - INDIVIDUAL ANINAL GROSS AND ICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/k/day ann bs 6a2301 oavs ow Tes: 108 wove of oem: SD GNrIoCsNRsooSCoAOpBPsNEaOCuRaACTLOiIRoTRNIBsEL:SATEDET(BsCeTlEeDcted lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE HTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AVTOLYSIS DID KOT PRECLUDE GTHREOANNoFnOeNLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESAUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. SSoEnCeTIONS OF THE FOLLOMING TISSUES WERE NOR PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACUTNIIoNOuNNtTSIOONF: THOERGAFNOLNLOOWYINCOGUNTTIESDS.UEISn WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR WICROSCOPIC = ompany Sanitized. Does not contain TSCA CBY To 0H--2D4a5y16G:avSaubgcehSrtoundiyc TinoxRiacistywith OneGeneration Reproductive Evaluations DuPon:5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS = P; ADULTS MALE RATS Grove: v-0 DOSE: 100 mg/kg/day ANDNAL 8: 643312 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE nSoENCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC -- NONE. mpany Sanitized. Does notcontain TSCA CBI 5 H0--2D4a51y6G:aSvuabgeehrSotnuidyc TinoxRiactistwyith One-Generation Reproductive Evaluations DuPont 5386 -_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Group: V-0 DOSE: 100 mg/kg/day. ANIMAL 3: 643313 DAYS ON TEST: 107 MODE OF DEATH: SD `MGIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC . NONE. Sompany Sanitized.DoesnotcontainTSCA BY 360 19.02-6D5a1y6G:avSaugbesSotnuidcy TinoxRicaittyvith One-Generation Reproductive Evaluations Dupo 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS VALE RATS GROUP: VII-O DOSE: 250 ma/ka/day ants 4: 6anise oave ox mest: 107 voDE OF DEATH: 5D cMrIoCsNRsOOSoACnBOsNePORERvMACATOLIIROTRNIESEL:SATEDET(EsCeTlEeDcted lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TVIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ER|ENOANUTEOLYZED; DEGREE OF AVTOLYSIS DID NOT PRECLUDE TRHGEoAFnOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, SNoEnCeT.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: --~ SEXEACAoTIIwNOeANTSIOONF: TOHREGAFNOLNLOOWTINCGOUNTTIESDSUETSN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - Sompany Sanitized. Dossnot containTSCA CBI Ta 9H0-2-4D5a1y6:GavSaugbcehrSotnuidcy TinoxRicaittsywith Ore-Generation Reproductive Evaluations DuPon5386 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Group: VIT-0 DOSE: 250 mg/kg/day. ANIMAL #: 643160 DAYS ON TEST: 109 ODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. OSENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE. Company Senitized. Does not contain TSCA CBI 62 9H0-2-4D5a1y6:GaSvuabgeehrSotnuidcy TinoxRiacsitywith OneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS ALE RATS GROv?: VII-0 DOSE: 250 mg/kg/day ANDMAL 8: 643161 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Company Sanitized. Dossnotcontaln TSCA CBI 6 910.-24D5a1y6G:avSaugbcehSrtoundiyc TinoxRicalttsywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Group: VIT-0 DOSE: 250 mg/kg/day. ANIMAL B: 643171 DAYS ON TEST: 107 NODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Company Sanitized. Does not contain TSCA CBI 61 H9-02-4D5a1y6:GavSaugbcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS ALE RATS GROUP: VII-0 DSB: 250 ma/ka/day ANAL #: 643191 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTHREGANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE: `Sompany Sanitized. Does not contain TSCA CBI 1365 9H0-2-4D5a1y6:GavSaubgcehSrtoundiyc TinoxRiactistywith One-CGencration Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS ALE RATS GROUP: VII-0 DOSE: 250 ma/ka/day. ANIL 8: 643192 DAYS ON TEST: 109 ODE OF DEATH: SD GMRIOCSRSOSOCBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THS FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC NONE `Sompany Sanitized. Doos not contain TSCA CBI 1366 9H0-2:4D5a1y6:GaSvuabgcehrSotnudiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS = 2; ADULTS MALE RATS GROUP: VII-0 0SE: 250 mg/kg/day. ANIMAL : 643203 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLAND, rEsTES MTHIECROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION. ~ SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. SompanySanitized.Doesnotcontain TSCA CBI 567 H9-02-4D5a1y6G:aSvuabgeehrSotnudiyc iTnoxRiactistywithOne Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS ALE RATS GROUP: VIT-0 Dose: 250 mg/kg/day ANIMAL 8: 643222 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSS DID NOT PRECLUDE OTHREGANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --- NONE Sompany Saniizad. Does not containTSCAcmt 68 H9-02-4D5a1y6:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generution Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS MALE RATS Grou: VII-0 DOSE: 250 ma/ka/day ANIMAL #643248 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNES:LATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Company Sanitized. Does not contain TSCA CBA T365 H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont $386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS HALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day. ANIMAL 0: 643249 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OHRSGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA.UTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE, NONE SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE CompanySanilized.DoesnotcontainTSCACBY 0 9H0-2-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS = Py ADULTS ALE RATS Group: VII-0 DOSE: 250 mg/kg/day. ANIMAL 8: 643274 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNOENCET,IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE Company Sanitized. Does not contain TSCACBI El H9-02-4D5a1y6G:aSvuabgeehrSotnudiyc iTnoxRiactistwyith One-Generaion Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: VIT-0 DOSE: 250 mg/kg/day. ANIMAL #: 643278 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNES:LATE (selected lesions:) NO ABNORMALITIES DETECTED MIPCRROOSSCTOAPTIEC OBSERVATIONS: - INFLAMMATION, SUBACUTE/CHRONIC, MINIVAL TEHPEIDIFDOYLMLIOSW,INGSETMIISNASLUEVSESWIECRLEESU,NRTEEMSATRIKSABLE NICROSCOPICALLY: COAGULATING GLAND, TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION - SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - Company Sanitized. Dossnotcontain TSCA CBI 7 9H0-2-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont$386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P. ADULTS MALE RATS GROUP: VII-0 088: 250 mg/ka/day ANIMAL #: 643281 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,NICROSCOPICALLY: COAGULATING GLAND, TeSTES MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: = SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CompanySanitized. Doesnotcontain TSCA CBI 7 9H0-2-4D5a1y6:GavSaugbcehrSotnuidcy TinoxRiactistywith One.Generation Reproductive Evaluations DuPon:-5386 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - P. ADULTS MALE RATS GROUP: VIT-0 DOSE: 250 mg/kg/day. ANIMAL #4: 643282 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE ETPHIEDIFDOYLMLIODWEISN,G TPIRSOSSTUAETSE,WERSEEMUINNARLEMVAERSKIACBLLEES,MICROSCOPICALLY: COAGULATING GLAND, `TESTES MTHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTRHGSANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: "= SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE ~ CompanySanitized.Dossnotcontain TSCACBI Te H9-02-4D5a1y6:GavSaugbeehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS Grou: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643285 DAYS ON TEST: 108 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESLATE (selected lesions): `EPTDIDYMIDES "Large, RIGHT; HEAD MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, NSOENCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF:TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - Company SaniDoetsniotczonetaidnT.SCACB! 7S H9-02-4D5a1y6:GaSvuabgeehrSotnudiyc iTnoxRiactsitwyith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PB, ADULTS MALE RATS GROUP: VII-0) DOSE: 250 mg/kg/day ANTHAL 8: 643289 DAYS ON TEST: 107 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE THHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTRHGEANFOLNLOOTWCIONUGNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSoExCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC . NONE -- Company Sanitized. Doesnotcontain TSCA CBI EQ 012-4D5a1y6:GaSuugbeelSrtoundiye TinoxRiactistywith OneGeneration Reproductive Evaluations Dupont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS = 2; ADULTS ALE RATS GROUP: VII-0 DOSE: 250 ma/kg/day wna v: 643299 oaYs on TEST: 108 obE OF DEATH: SD GMrIoCsRVsOoSCoAaOBsPNeIOrCRvMaCATOLIRIORTNEISLE:SATEDET(EsCeTlEeDcted lesions) MICROSCOPIC OBSERVATIONS: NONE TEHPEIDIFDOYLMLIOSW,INGPRTOISTSASTUEE,S WSEERMEINAULNREVWESAIRCKLAEBSL,E MICROSCOPICALLY: COAGULATING GLAND, restrs MTIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE GTRHaEaNFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, Tone SNEoCwTeIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ~ ESEXCATMIIONNASTIOOFN THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAISCLIEESN:T FOR MICROSCOPIC Nong. - Company Sanitized. Does not contain TSCACBI 5 H-24516: Subehronic 90-Day Gavage Study TinoxRicaisty with One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS MALE RATS GROUP: VII-0 DOSE: 250 ma/kg/day. ANIMAL 8: 643302 DAYS ON TEST: 109 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFOLNOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. Company Saniized. DoesnotcontainTSCA CBI 7 H9-02-4D5a1y6:GavSaugbeehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS MALE RATS Grou: vII-0 Dose: 250 ma/ka/day ANIMAL #: 643317 DAYS ON TEST: 109 NODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. Company Sanitized. DoesnotcontainTSCACBI a 01.-2D4a51y6:GavSaugbcehSrtoundiyc TinoxRicaittsywith One Generation Reproducive Evaluators DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: 11-0 DOSE: 0 mg/kg/day ANTAL 0: 643319 DAYS ON TEST: 119 KODE OF DEATH: SD GMRIOCSRSOSOCBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE. TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGANFONLOLTOWCINOGUNTTIESDSUTENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, Nouz: NSoEwCeT:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC OnE. - Company Sanitized. Doesnotcontain TSCACBI ww H9-02-4D5a1y6:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIHAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Grove: 11-0 DOSE: 0 ma/ko/day ANIMAL : 643343 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT WADE, NONE. SNEONCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE Company Sanitized. Doesnotcontain TSCA CBI El 012-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRicalttsywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GRovR: TI-0 DOSE: 0 mg/kg/day ANIMAL #: 643350 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVHASGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NONE --- Sompany3Sanitized. DonotecontsainTSCA CBI 8 9H-02-4D5a1y6G:aSvuabgcehSrtoundcy TinoxRiactistwyith OnGeeneration Reproductive Evaluations Dupont 5386 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RAS GROUP: 11-0 DOSE: 0 mg/kg/day ANTAL : 643352 DAYS ON TEST: 119 oDE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTORIROENLSA:TE. (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE aTHEcmFOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANVTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWCINOGUNTTIESDSUTENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NouE: NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACNTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC - NouE. jompany Santized. Doos not contain TSCA CBI TE 910.2-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRicaittsywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: 11-0 DOSE: 0 mg/kg/day ANIMAL : 643363 DAYS ON TEST: 122 NODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNBSL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: HSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE. `Sompany Sanitized. Doesnot contain TSCACBY 8 H-24516: Subehronic Toxicity 90.Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND NICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS GROUP: TI-0 DOSE: 0 mg/kg/day ANIMAL 8: 643378 DAYS ON TEST: 125 ODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE NSOENCET,IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Sompany Sanlized. Doesnot contain TSCA CBI 1385 H-24516: Subchronic Toxicity 90-Day Gavage Study inRatswith One-Generation Reproductive Evaluations DuPon5386 - INDIVIDUAL ANDNAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: 11-0 DOSE: 0 mg/kg/day ANDOL #0 643386 DAYS ON TEST: 126 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREVARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. - "ompany Sanitized. Does not contain TSCA CBI 3 H-24516: Subchronic Toxicity 90-Day Gavage Study in Ruts with OneGeneration Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FEMALE RATS Group: 11-0 DOSE: 0 mg/kg/day ANIMAL 8: 643393 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNSSL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: OVARIES, UTERUS, MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE, NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ~ ESXEACMTNIIONONANETSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC CompanySanitized. Does notcontainTSCACBY TE -- H9-02-4D5a1y6G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Group: TI-0 DOSE: 0 mg/kg/day ANIMAL #: 643394 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRROENLSA:TES (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NONE. Company Sanitized. Does not contain TSCA CBI TEE 9H0--24D5a1y6G:avSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: 11-0 DOSE: mg/kg/day ANDHAL 8: 643397 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSOCBOSPEIRCVACTOIRORNESL.ATE (selected lesions): Liver - DISCOLORATION, TAN, MOTTLED, LEFT MICRoOmSHECROPIC OBSERVATIONS: - LIVER: NECROSIS, FOCAL, MINIMAL TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: - SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Company Sanitized. Docsnotcontain TSCA CBI 8 9102-4D5a1y6G:avSaugbeehSrtoundiyc iTnoxRiatcslywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: 11-0 DOSE: 0 wg/ka/day ANIMAL : 643401 DAYS ON TEST: 121 MODE OF DEATH: SD `MGIRCORSOSSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHISCROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE. CompanySanitized. Dossnotcontain TSCA CBI EQ -- 9102-4D5a1y6G:avSaugbcehSrtoundiyc iTnorRicaittsywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS Group: 11-0 DOSE: 0 na/ka/day ANIMAL 8: 643414 DAYS ON TEST: 119 MODE OF DEATH: SD. GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL.ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NONE SompanySanitized.Doesnotcontaln TSCACBI T91 -- H9-02-4D5a1y6G:aSvuabgeehrSotnuidcy iTnoxRiacistyithOneGeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: 11-0 DOSE: 0 ma/ks/day ANDHAL #643419 DAYS oN TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNRENARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWC.INGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNEoCnTeIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF:THOREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE Sompany Saniized. Doesnot contain TSCA CBI 0 --- 9H0-2-4D5a1y6:GaSvuabgcehrSotnuidcy TinorRiacttsywith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANDMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS FEMALE RATS DOSE: 0 mg/ka/day ANDOAL 8: 643420 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) SKIN - ALOPECIA, PERINEUM; RIGHT FRONT LIMB MICROTOHSECROPIC OBSERVATIONS: - SKIN: NO ABNORMALITIES DETECTED TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHISCROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nog SNOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; THOREGAFNOLNLOOWTICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Sompany Sanitized. ogg otcontain TSCA cp) 9 -- H9-02-4D5a1y6:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5386 --- INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Grove: 11-0 DOSE: 0 mg/ka/day ANTAL 8: 643421 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE Company Senitized. Dassnotcontain TscA car 9% -- 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5386 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: 11-0 DOSE: 0 mg/kg/day ANDOAL 4: 643447 DAYS ON TEST: 120 oDE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREWARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUTENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE `Company Sanitized.Doesnotcontain TSCA CBI 1395 H9-02-4D5a1y6:GaSvuabgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIVAL GROSS AND MICROSCOPIC OBSERVATIONS- P. ADULTS FEMALE RATS GROUP: 11-0 DOSE: mg/kg/day ANIMAL #643455 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL.ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE OSENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;THOREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. Company Sanitized. DoesnotcontainTSCA CBI E3 -- H9-02-4D5a1y6:GavSaugbcehSrtoundiyc iTnoRxaitcsitwyith OneGeneration Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND WICROSCOPIC OBSERVATIONS = Py ADULTS FEMALE RATS Group: 11-0 DOSE: 0 mg/kg/day ANIMAL 8: 643459 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, `Nowe NSOENCET,IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIINOANTSIOONF: THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE BE -- CompanySanitized. Does notcontain TSCA CBI EE 9102-4D5a1y6G:ovSaugbeehSotniyciTnoRitcstywith OneGeneration Reproducive Evaluations Dupont5386 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - p. ADULTS FEMALE WATS GROUP: TIO DOSE: 0 ma/ka/day Ano: sa3ara ons on Test: 122 MODE oF DEATH: 5D GMrIoCsRsOSCoOpPsIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITI8S DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPTCALLY: NONE TVHEECROFSOCLOLROIWCINGEXTAIMISNSAUTEISONW:ER|ENOANUTEOLYZED; DEGRES OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCINOGUNTTEIDSSUTEnSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. Tone SNEoCnTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF:TOHREGAFNOLNLOOWTINCGOUTNITSESDUE1S WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC po - CompanySanitized. Does nocontainTSCACHt ee 9H-02-4D5a1y6:GavSaugbeehSrtoundiyc TinoxRiactistwyith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS FENALE RATS Group: TI-0 DOSE: 0 mg/kg/day ANDHAL 8: 643480 DAYS ON TEST: 122 ODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREVARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE `TOHREGAFNONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF;THOREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Company Sanitized. Does not contain TSCA CBI T%5 -- 9H0--2D4a5y16G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPon5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: 1V-0 DOSE: 25 mg/kg/day ANIMAL : 643325 DAYS ON TEST: 123 HODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE CompanySanitized.Doesnot contain TSCA CBI Tao 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 --~ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P. ADULTS FEMALE FATS GROUP: 1v-0 D0SE: 25 ma/ka/day ANIMAL 4: 64333 DAYS ON TEST: 120 MODE OF DEATH: SD GMIRCORSOSSCOOBPSIECRVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE - Sompany Sanitized. Doss notcontainTSCACB Teor 209H-0:2-D6Da5ay1yG6G:aavvSaauggbeeeShSrttouunddiyyciTinnoRxRaiacttisstwywiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt:5$338866 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS GROUP: 1v-0 DOSE: 25 mg/kg/day ANIMAL 643342 DAYS ON TEST: 123 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, oSEgCTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIIONNATSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. Company Sanitized. Does not contain TSCACBY Taz -- 9H-02-6D5a1y6G:avSaugbeehSrtoundiyc TinoxRiactistwyith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FEMALE RATS RoR: TV-0 DOSE: 25 ma/ka/day ANIMAL 3: 643369 DAYS ON TEST: 119 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE. Company Sanilized. Does not contain TSCACBI -- 1303 9H0-2-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANDNAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Grove: TV-0 DOSE: 25 ma/ka/day ANIMAL 8: 643372 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUTENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT OR MICROSCOPIC _ NONE `CompanySanilized,Doesnotcontain TSCACBI Tos 9H0-2-4D5a1y6:GaSvuabgcehrSotnuidcy TinorRiactistwyithOne-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND NICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS Grove: TV-0 DOSE: 25 ma/ka/day ANDHAL 8: 643376 DAYS ON TEST: 120 ODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE -- Company Sanitized.Doesnotcontain TSCA CBI Taos 0H--2D4a51y6:GavSaugbcehrSotnuidcy TinoxRicaittsywith One-Generation Reproductive Evaluations DuPont-5386 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: 1-0 DOSE: 25 na/ka/day ANIMAL #: 643395 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE: SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE Company Sanltized. Doesnotcontain TSCA CBY 3 20H0--:2DD4a5a1yy6G:GoavSvuaabggceehSrStotunudidycyiTinnoRxRaiatctisstwywiitthhOOnnee-GGeenneerraatiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DuDuPPoonnti-55338866 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P. ADULTS FEMALE RATS GROUP: 1V-0 DOSE: 25 mg/kg/day ANDMAL 8: 643399 DAYS ON TEST: 132 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA.UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;THOREGAFNOLNLOOWTINCGOUTNITESDSUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC -- ONE. Company Sanitized. Doss not contain TSCA CBI -- Tao -- 2-920D4-5aD1ay6yG:GuavSvuaabggceehSrStotunudidycyiTinnoRxRaiatctisstwywiitthhOOnnee-GeGneenreartaiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt55338866 - INDIVIDUAL ANDMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: 1V-0 Doss: 25 mg/kg/day. ANDMAL #: 643400 Das oN TEST: 121 NODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. Company Sanitized. Doesnot contain TSCACBI 3 9H0-2-4D5a1y6:GaSvuabgcehrSotnudiyc TinoxRiacittywith One- Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: 1V-0 DOSE: 25 mg/ka/day ANTHAL &: 643403 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: - SEXEACMTNIIONONANETSIOONF;TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC Company Sanltized. Doesnotcontain TSCA CBI 705 -- H9-02-4D5a1y6G:aSvuabgcehrSotnudiyc TinoxRiactistwyith One-Generaton Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS GROUP: 1V-0 DOSE: 25 mg/kg/day ANIMAL : 643418 DAYS ON TEST: 125 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTEALBLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE Sompany Sanitized. Doesnotcontain TSCA CBI _--_-- 9H02-4D5s1y6:GaSvuabgcerSotnuidcy TinriRcaitstywith OneGeneration Reproductive Evaluations Duponc5386 - INDIVIDUAL ANZMAL GROSS AND MICROSCOPIC OBSERVATIONS - 9, ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 ma/ka/day Ava 4: 643422 oavs on Test: 119 oDE OF DEATH: 5D GMrIoCsRsOSCopOsPsIRCUACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TaHcEtFAOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: OVARIES, UTERUS, MTIHCEROFSOCLOLPOIWCI.NGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSTWNECRIEDESNCEEVETRAEBLLYESA:VTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, one: SNEoCwTeIONS OF THS FOLLOWING TISSUSS WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION. SEXEACMNTIoINwOAeNTSIOONF; THOERGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Company Sanitized.DossnotconteinTSCACBL Te 2H90-0-2-D4Du5ay1y6G:GaaSvvuaabggeeehSrStotunuddiyyciTinnoRxRaiatctsistwwyiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt55338866 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - B, ADULTS FEMALE RATS GROUP: 1v-0 0SE: 25 mg/ke/day. ANIMAL #: 643438 DAYS ON TEST: 121 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected NO ABNORMALITIES DETECTED lesions) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTONICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; NONE TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC `Company Sanilized. Doesnotcontain TSCACRY Taz -- 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FALE RATS GROUP: IV-0 DOSE: 25 mg/ka/day ANDOAL 0: 643445 DAYS ON TEST: 119 ODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICRUOTESRCUOSPIC OBSERVATIONS: - DILATATION, GLAND/LUMEN, MINIMAL THE FOLLOWING TISSUES WERE UNREVARKABLE MICROSCOPICALLY: OVARIES, VAGINA TMHIECROFSOCLOLPOWIICNGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: - SEXEACMTNIIONONANETSIOONF;THOERGAFNOLNLOOWTINCGOUTNITESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC Sompany Sanitized. Doesnot containTSCA CBI Tan -- 9H0-2-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: 1V-0 DOSE: 25 mg/kg/day ANDIAL 8: 643452 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSOCBOSPEIRCVACTOIRORNESL:ATE (selected NO ABNORMALITIES DETECTED lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: SNOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE "ompanySanitized. Doss not contain TSCA CBI _--_-- H9-02-4D5a1y6G:avSaugbeehSrtoundiyc iTnoxRiactistwyith OneGeneration Reproductive Evaluations DuPont-5386 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - B, ADULTS FEMALE RATS GROUP: 1U-0 Dose: 25 mg/kg/day ANIMAL 4: 643457 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUETOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN.T FOR MICROSCOPIC -- NONE `Sompany Sanitizad. Doss notcontainTSCA CBI Tas -- 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: 1V-0 DOSE: 25 mg/kg/day ANIMAL #: 643464 avs ON TEST: 121 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEEXCATMIINOANTSIOONF: THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. ~ompany Sanitized.DoesnotcontainTSCACB --------Ta-- e ------ H9-02-4D5a1y6G:avSaugbeehSrtoundiyc iTnoxRiactistwyith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND NICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: 1V-0 DOSE: 25 mg/kg/day ANIMAL 643475 DAYS ON TEST: 120 ODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACOTRIROENLSATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLONING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTEREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSoENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF:THOERGAFNOLNLOOWTICNOGUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE. `mpanySanitized. DoesnotcontainTSCACBI Ta -- 9H0--2D45a1y6G:aSvuabgeehrSotnuidcy iTnoxRiactistwyith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS GROUP: 1v-0 DOSE: 25 mg/kg/day ANTHAL 4: 643479 DAYS ON TEST: 120 MODE OF DEATH: 8D. GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TEE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOTWINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE. -_-- `ompany" SaSnalntized. Doesnotcontain TSCA cay Tas 1.24516: Subehronic 90-Day Gavage Study TinoxRicaisty with One-Generation Reproductive Evaluations Dupont5386 - INDIVIDUAL ANTMAL GROSS AND MICROSCOPIC OBSERVATIONS = P, ADULTS FEMALE RATS Group: TV-0 DOSE: 25 mg/kg/day ANDHAL 8: 643490 DAYS ON TEST: 119 MODE OF DEATH: SD. GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIIONNATSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE. Company Sanitized.DoesnotcontainTSCA CBI Ta H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/ka/day ANIMAL #: 643320 DAYS ON TEST: 122 NODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNESL.ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWCIONUGNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF;THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC NONE. Company Sanitized. Does not contain TSCA CBI T20 H-24516: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P. ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day. ANIMAL B: 643331 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: OVARIES, UTERUS, MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT WADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF: TOHREGAFNOLNLOOTWICNOGUNTITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - NONE. Company Sanitized. Does not contain TSCA CBI Tar -- 0H--2D4a51y6:GaSvuabgeehrSotnuidcy iTnoxRiactistywith One Generation Reproductive Evaluations DuPont 5386 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P: ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL 0: 643333 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --- NONE. CompanySanitized.Doesnotcontain TSCA CBI Ta 9H0-2-4D5a1y6:GavSaugbcehSrtounidcy TinoxRiactistwyith One-Generaton Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 9; ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day. ANIMAL : 643337 DAYS ON TEST: 120 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, NSOENCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF: THOERGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC _ NONE. `CompanySanitized.Doesnotcontain TSCA CBI 2 -- H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats with One-Generaion Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL : 643339 DAYS ON TEST: 120 ODE OF DEATH: SD. GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFOLNLOTOWICNOGUNTTEIDSSUTENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE: NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIINOANTSIOONF: THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC -- NONE Company Sanitized. Doesnotcontain TSCA CBI a2 -- H9-02-4D5a1y6G:aSvuabgeehrSotnudiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day. ANIMAL 643349 DAYS ON TEST: 121 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEEXCATMIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. ompany Sanitized. Does not contain TSCA CBI 3 -- 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith OreGeneration Reproductive Evaluations DuPont 5386 -_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - o, ADULTS FEMALE RATS Group: VI-0 DOSE: 100 mg/kg/day ANDIAL #: 643353 DAYS ON TEST: 120 MODE OF DEATH: sD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTIHCEROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; TOHREGAFNOLLNOOTWINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE. -- CompanySanitized.Doesnotcontain TSCACBY -- 3 910.-2D45a1y6G:aSvuabgcehrSotnuidey TinoxRiactistywithOne.Geneon Reproductive Exalusions Dupon5356 - INDIVIDUAL, ANHAL GROSS AND MICROSCOPIC OBSERVATIONS - 7, ADULTS FENALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ADL 4: 6433s? oavs on mest: 119 oDE oF pEATH: 8D GHIrCoRNsOosSCoAOnBPsNIsOCRR.vUAACTLOIIROTRNIESEL:SATEDET(EsCeTlEeDcted lesions:) MICRrOaSCnOsPIC OBSERVATIONS: - DILATATION, GLAND/LUNEN, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: OVARIES, VAGINA TMIHCEROFSOCLOLPOIWCI.NGEXATMIISNSAUTEISON:WER=ENOANUTEOLYZED; DEGRES OF AUTOLYSIS DID NOT PRECLUDE TGHREATNoFnOeNLOLTOWCIONUGNTTEIDSSUTEhSIWNECRIEDESNCEEVETRAEBLLYESA:VTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. SSEoCnTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION. SEXEACMNTIoINnOAeNTSIOONF, TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNGSEUFTFAIBCLIEESNT FOR MICROSCOPIC - --- CompanySantized. DoesnotcontainTSCACEN H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 ma/ka/day ANIMAL : 643385 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNBSL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: _ SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. - `CompanySanitized.Doesnotcontain TSCACBI Taw : H9-02-4D5a1y6:GaSvuabgcehrSotnudiyc TinoxRiactistywithOGneeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANTMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 ma/kg/day. ANDHAL #: 643407 DAYS ON TEST: 120 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. `NONE, NSOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --~ NONE CompanySaniized.Doesnotcontain TSCACBI 3 910.2-4D5a1y6:GavSaugbcehSrotnuidcy iTnorRiatistywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: VI-0 DOSE: 100 mg/kg/day. ANIMAL 8: 643416 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -~ NONE Company Sanitized. Does not contain TSCA CBI 50 -- 3H90-0-2-D4Da5a1yy6G:GaavvSaauggbeeehSSrttouunddiyyciTinnoRxaRiatctsistwywiitthhOOnneeGeGenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DuDuPPoonntt-35338866 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 200 mg/kg/day. ANIMAL #: 643427 DAYS ON TEST: 122 MODE OF DEATH: SD MGRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE WICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOREGAFNOLNLOOTWINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE. sompany Sanltized. Dossnotcontain TSCA CBt -- Tan H9-02-4D5a1y6G:aSvuabgeehrSotnudiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon$386 = INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL 8: 643428 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOOBSPEIRCVACTOIRORNES.LATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC --- NONE. Company `panySSeanintized. Doesnotcontain TSCAcB 2 -- 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRicaittsywith One-Generaton Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day. ANIMAL 8: 643434 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSTS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, one SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE Pe Company Sanitizod. Does notcontalnTSCA!om 3 -- 0H--2D4a51y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL 8: 643439 DAYS ON TEST: 122 NODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREVARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISON:WERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFOLNLOTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT BRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN.T FOR MICROSCOPIC _ NONE Company Sanitized. Doss not containTSCACB Ta -- 0H--2D4a51y6:GaSvuabgeelrSotnuidcy iTnorRiactistywith One-Generaton Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/ka/day ANIMAL 8: 643454 DAYS ON TEST: 99 MODE OF DEATH: ED GMRIOCSRSOSCOOBPSIECRVACTOIRORNESLATE (selected lesions): SKIN - STAIN, RED, FACE MICROSCOPIC OBSERVATIONS: NONE VTAHGEINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:EREHOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC = NONE. CompanySanitized.DossnotcontainTSCACBI 3 -- 290H0-:-2DD6au5yy1G6G:aavSvuaabggeeehSrStotunuddiyyciTinnoRxRaiacttisstwywiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPpoonnte-55338866 -~ INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL 0: 643460 DAYS ON TEST: 120 NODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE: SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC --~ NONE. Company Sanitized. Dossnot containTSCA CBI 436 2010.--2DD4a5a1yy6G:GaovSavugbeehSrStotunudidycyiTinnoxRRiaacttisstwywiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DuDPuopnoe:35338866 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - By ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 ma/kg/day ANIHAL 4: 643470 DAYS ON TEST: 119 WoDE OF DEATH: sD GMRIOCSNRSOOSCOAOBBPSNIEOCRRVMAACTLOIIROTRNISSEL:SATEDET(EsCeTlEeDcted lesions) MICROSCOPIC OBSERVATIONS: NONE TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMIHCEROFSOCLOLPOIWCI.NGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNCEIRDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, Row SNoEwCeT:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC SKAVINATION ~ SEXEACMTDIWOANTSIOONF;THOREGAFNOLNLOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Sompany Senitized. Does notcontainTSCA CBI -- we ZH92-0:2-4DD5ea1yy6:GGaaSvvuaabggeeehSrStotunuddiyyciTinnoRxRaiacttisstwywiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonnttS$338866 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANTHAL 8: 643473 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSOCBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICURTOESRCUOSPIC OBSERVATIONS: - DILATATION, GLAND/LUMEN, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:EREHOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: -- SEXEACMTIINOANTSIOONF; THOERGAFNOLLNOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN.T FOR MICROSCOPIC NONE: Sompany Sanltized. Dossnotcontain TSCA CBI Tan 0H0---2DD4aa51yy6G:GaSavuagbgceehSvStotunudidycyiTinnoRrRiacatitstsywwiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvxaalluuastiioonnss DDuuPpoonntt35338866 ~ INDIVIDUM, ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS - P ADULTS FEMALG RATS GROUP: VI-0 DOSE: 100 mg/kg/day Anas 4: 64348 DArs on TEST: 129 Hove oF DEATH: SD GMRIOCSNRSOOSACOBOBNPSOIECRRVMACATOLIIROTRNIESEL:SATDEET(EsCeTlEeDcted lesions): MICuRrOESRCUOSPIC OBSERVATIONS: - DILATATION, GLAND/LUEN. MILD THE FOLLOWING TISSUSS WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA TNHIECROFSOCLOLPOIWCINGEXTAIMSINSAUTEISONW:ERENOAUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRUGEANFOLNLOOTNICNOGUNTTIESDSUTENSIWNECRIEDENSCEEVERTAEBLLYESA:VTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, None SNoEwCeT.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOWTINCGOUTNITESDSUEISN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC Nowe. `ompany Sanitized. Dossnotcontain TSCA CBI ww H9-02-4D5a1y6:GaSvuabgeehrSotnudiyc TinoxRiactistwyith One-Generation Reproductive Evaluations DuPont5386. -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Group: VIII-0 DOSE: 250 mg/kg/day ANDOAL #: 643326 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNOENCET,IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN.T FOR MICROSCOPIC _ NONE - Company Sanitized. DoosnotcontTSaCAiCnEA To H9-02-4D5a1y6G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS GROUP: VITI-0 DOSE: 250 na/kg/day ANIMAL #: 643328 DAYS ON TEST: 121 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNOENCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. - Company Sanltized.Doesnotcontain TSCACBI Taal 19.02-0D5a1y6:GeSvuabgsSotnuidcy TinoxRiactistywith One-Generation Reproduce Evaluons Dupont - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FENALE WATS GROUP: VIII-0 DOSE: 350 ma/ka/day ana v: 6a3335 oavs ox Tests 121 wp OF DEATH: 5D GMIrCoRsNOsOSCoAOBnPNsIOCsR.aMvACaLOIIRoTRNIEsEL:SATEDET(EsCeTlEeDcted lesions:) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THIHCERGFSOCLOLPOIWEI.NGBXATNIISNSAUTEISON:WERENOANVTEOLYZED; DEGRES OF AUTOLYSIS DID NOT PRECLUDE HGRSGTAoNFnOeNL0L7OWICNOGUNTTEIDSSUTENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. SSoEnCeT.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: - ESXEACMoTIINNO.ANTSIOONF: THOREGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC `CompanySenitized,DoesnotcontainTSCACB --- wm H9-02-4D5a1y6G:avSaugbcehSrtoundiyc iTnoxRiactistwyith One-Generaion Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS Group: VIII-0 DOSE: 250 ma/kg/day. ANIMAL : 643338 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL.ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF;THOERGAFNOLNLOOTWICNOGUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC - Nowe `Company Sanitized. Does not contain TSCACBY 3 -- 9H02-5D1ay6:GavSaugbeehSrtoundiyc TinoxRicaistywithOneGeneration Reproductive Evaluations Dupont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FENALE RATS GROUP: VIII-0 DOSE: 250 m/ka/day ANIMAL #643346 DAYS ox TEST: 91 NODE OF DEATH: AK GHrIoCsRsOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) sStwoAmLaLciItNTESTINE sky =~ bDrIsSTTeENNDDEEDD WwiItThH GGaAsS,, SsEeVvEeRREe = sav, Rep, FacE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANVIEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA.UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, Nowe: NSoEuCET:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION "~ SEEXCATIINOANTSIOONF; TOHREGAFNOLNLOOTWICNOGUNTTIESSDUETSn NONE. WIENRCEIDEINNCSEUFTFAIBCLIEESN.T FOR MICROSCOPIC `Company Sanitized. Doosnotcontain TSCACEH _-- To 0H--2D4a51y6:GvSaubgcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS Group: VITI-0 DOSE: 250 mg/kg/day ANIMAL 8: 643348 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREVARKABLE NICROSCOPICALLY: OVARIES, UTERUS, MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE. NSOENCET,IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: _ ESXEACMTIINOANTSIOONF: TOHREGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. Company Sanltized.Doesnotcontain TSCA CBI Teas 9204-5D1ay6:GovSaugbcehSrotnidc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPons386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FOALS WATS GROUP: VITO DOSE: 250 m/ka/day AvnoL 4: 643365 oars on Test: 122 woDE OF DEATH: SD GMrIoCsRNsOOSCoAnOBsPNEIORCRVMACATOLIIROTRNIESEL:SATEDET(EsCeTlEeDcted lesions): MICROSCOPIC OBSERVATIONS: NOvE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ER|ENOANUTEOLYZED; DEGRES OF AUTOLYSIS DID NOT PRECLUDE RTHGEoAnFeON:LOLTOWCIONUGNTTEIDSSUTEhSIWNECRIEDENSCEEVETRAEBLLYESA:VTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. SSoEnCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: _ ESXEACMTNoIInNOeAN.TSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUETSN WIENRCEIDEINNCSEUFFTAIBCLIEESN:T FOR MICROSCOPIC -- Company Sanitizad.DossnotcontTSaCAiCnBI ws 910.2-4D5a1y6:GaSvuabgehoSntuidcy TinorRiatcsiywith One Generation Reproductive Evaluations Dupont 5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - 2; ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL 4: 643375 DAYS ON TEST: 121 NODE OF DEATH: 5D GNrIoCsRsOSCoOsPsIECRvCATOIRORNESLATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, on SNoEnCeT:IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ~ SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC one: - `Company Sanitizod. Doos notconTtSaCAiCBnY ww H9-02-4D5a1y6:GaSvuabgeehrSotnudiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL 8: 643013 DAYS ON TEST: 122 1ODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE ~~ Company Sanilized. Does not contain TSCA CBI Tas 24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ~ INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS - 2, ADULTS FEMALE RATS Group: VITI-0 DOSE: 250 mg/kg/day ANIMAL : 643417 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFOLNLOOTWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTEALBLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: ESXEACMTIINOANTSIOONF; THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE CompanySanitized. Doasnotcontain TSCA CBI 3 -- 910.-2D45a1y6G:aSvuabgcehrSotruidcy TinorRiacittsywith One-Generation Reproductive Evaluations Dubont5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - By ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mo/ka/day ANIMAL 8: 643424 DAYS ON TEST: 119 NODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESAUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE, rSoENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWINCGOUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE - `CompanySanltized. DosnotcontTSaCAiCBnI wo ~ H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats with Ore-Generaton Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS Grou: VIII-0 DOSE: 250 mg/kg/day. ANIMAL 4: 643629 DAYS ON TEST: 106 MODE OF DEATH: FD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions): uKTIeDRNUESYS -~ HDIELMAOTRARTHIAOGNE, BILATERAL, PELVIS skmn ~- OSBTSAITNR,UCTRIEDO,N, VEBONDTYR;ALPLBOADCYE,NTAFACE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGAFNONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE HSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXANINATION: -- ESXEACMTNIIONONANETSIOONF;THOERGAFNOLNLOOWTINCGOUTNTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC `Company Sanitized. Does not contain TSCA CBI -- Tat 910.2-4D5a1y6:GaSvuabgcehrSotnudiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS- P, ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANTAL #: 643430 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE VTHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, HONE, NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: _ SEXEACMTIINOANTSIOONF: THOERGAFNOLNLOOTWICNOGUNTTIESDSUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE. Company Sanltized. Dossnotcontain TSCA CBI -- = 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRiacittsywithOneGeneration Reproductive Evaluations DuPont 5386 ~ INDIVIDUAL ANTHAL GROSS AND NICROSCOPIC OBSERVATIONS - 2: ADULTS FEMALE RATS Group: VIII-0 DOSE: 250 ma/kg/day ANIMAL 8: 643431 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE TVHAEGINFAOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, TMHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNOENCET.IONS OF THS FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: _ SEXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC NONE. CompanySanitized. Does not contain TSCA CBI 5 -- 9H0-2-4D5a1y6:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - Py ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day. ANDNAL : 643440 DAYS ON TEST: 122 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOWIICNGEXTAIMISNSAUTEISONW:ERENOAUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTHREGANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESAUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF;THOREGAFNOLNLOOWTINCGOUNTTIESSDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC NONE CompanySanltized.Doesnotcontain TSCACBY -- Tasa H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P: ADULTS FEMALE RATS Group: VIII-0 DOSE: 250 ma/ke/day. ANDIAL #0 643443 DAYS ON TEST: 119 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions:) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXATMIISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TORHGEANFONLOLTOWICNOGUNTTIESDSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE NSOENCETIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEEXCATMIIONNATSIOONF;THOERGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC _ NONE. Company Sanltized. Does not contain TSCA CB Tass -- 9H0--2D45a1y6G:avSaugbcehSrtourdiyc iTnorRiactistywith One-Generaion Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS AND NICROSCOPIC OBSERVATIONS - P: ADULTS FENALE RATS GROUP: VIII-O DOSE: 250 mg/ko/day ANDHAL b: 643449 DAYS ON TEST: 125 NODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) No ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE TMHIECROFSOCLOLPOIWCINGEXTAMIISNSAUTEISONW:ERENAOUNTEOLYZED: DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWCIONUGNTTEIDSSUTENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOR WADE, Noe. SNOERCET.IONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: SEXEACMTIINOANTSIOONF; THOERGAFNOLNLOOWTINCGOUTNITSESDUETSN WIENRCEIDEINNCSEUFTFAIBCLIEESN.T FOR MICROSCOPIC -- NONE. `Company Sanitized. Does notcontain TSCA CBI -- uw -- 9H0-2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FEMALE RATS Group: VITI-0 DOSE: 250 ma/ke/day ANIMAL #: 643467 DAYS ON TEST: 125 MODE OF DEATH: SD GMRIOCSRSOSCOBOSPEIRCVACTOIRORNESL:ATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE MTHIECROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE OTRHGEANFONLOLTOWCINOGUNTTEIDSSUIENSIWNECRIEDENSCEEVETRAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, NONE oSEnCeTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION ESXEACMTIINOANTSIOONF;TOHREGAFNOLNLOOWTINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESNT FOR MICROSCOPIC -- NONE CompanySanitized. DoesnotcontainTSCA CBI TST 0H--2D4a51y6:GavSaugbcehSrotnuidcy iTnoxRiactistywith One-Generaton Reproductive Evaluations DuPont5386 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 ma/ka/day. ANIMAL 0: 643468 DAYS ON TEST: 125 MODE OF DEATH: SD GMRIOCSRSOSCOOBPSIECRVACTOIRORNESL:ATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE NICROSCOPICALLY: NONE TMIHCEROFSOCLOLPOIWCINGEXTAIMISNSAUTEISONW:ERENOANUTEOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE TOHREGANFONLOLTOWICNOGUNTTEIDSSUIENSIWNECRIEDESNCEEVERTAEBLLYESA:UTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. NONE SNEOCNTEIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION SEXEACMTIINOANTSIOONF; TOHREGAFNOLNLOOTWINCGOUTNITSESDUEISN WIENRCEIDEINNCSEUFTFAIBCLIEESN:T FOR MICROSCOPIC _ NONE -- `CompanySanitized. DoesnotcontalnTSCACEA Tash -- H9-02.4D5a1y6:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX 00 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F; PUPS. - Company Sanitized. Dossnot contain TSCA CBI = H-24516: Subchronic Toxicity 90-Dsy Gavage Study in Rats withOneGeneration Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F; PUPS EXPLANATORY NOTES Abbreviations FD = Founddesd DuPont5386 Company Sanitized. Doss not contain TSCACEU 1260 9H0-.24D5a1y6G:aSvuabgcehSonyic TinoxRicaittywith One Generation Reproduce Evausions - IXDIVIDUAL ANIHAL GROSS OBSERVATIONS - F, 2025 OM GROUP: 11-0 DOSE: 0 MG/KG/DAY oAWonDmeeLn Cpeuxp NwUsiMuBrmER onoarTsest eaze osseRvATIONS Gass uw 67028 21 FD No ABNORMALITIES DEFECTED Duponcs386 - CompanySanitized.Doesnotcontaln TSCACBY -- we 9H0-2-4D5a1y6:GavSaugbechSrtonuidcy TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont5386 - INDIVIDUAL ANDIAL GROSS OBSERVATIONS- F; PUPS DAM GROUP: TV-0 DOSE: 25 MG/KG/DAY oANaIMAL PUP ANsIuMpAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 643376 M 647033 643800 M 647034 -21 FD -21 FD LSUTNOGMSACH- N-OTNOEMXIPLAKNDESDPOT SLUTNOGMSACH- -NONTOEMXIPLAKNDESDPOT Company Sanitized.Doesnot contaln TSCACBI Te 19.02-4D5a1y6:GavSaugbechSrtouidcyTionxRicaistywithOneGeneration Reproductive Evaluations Dupont 5386 - INDIVIDUAL ANTAL GROSS OBSERVATIONS - , PUPS DAM GROUP: VI-0 DOSE: 100 MG/KG/DAY oAaNnAL PUP ANwDoWrML avs NUMBER SEX NUMDER ON TEST FATE OBSERVATIONS 63320 Fo 66477005422 2211 EFDD NNOo AABBNNOORRMMAALLIITTIIEESS DDEEFTEECCTTEEDD 643439 667700337 2211 FFDD NNOO AABBNNOORRMMAALLIITTIIEESS DDEETTEECCTTEEDD F78070557 2211 FFDD NNOO AABBNNOORRMMAALLIITTIIEESS DDeEmTeEcCTTeEDD 643331 M 647038 21 FD SLUTNOGMSACH- N-OTNOEMXIPLAKNDESDeoT 6703-21 FD LSUTNOGMSACH- N-OTNOEMXIPLAKNDESDpor 67060 21 ED 67001 21 FD SSLUTTNOOGMMSAACCHH- N--ONTNooEXMMPIIALLNKKDESsDPp.OoTr Fo 64058 21 0 SLUTNOGMSACH- NOTNoEMXIPLAKNDSEPDOT 67059 21 E> SLTUONMGSACH- N-OTNOEMXIPLAKNDSEDor - 647060 -21 FD SLTUONMGSACH- N-OTNoEMXIPLAKNDESDpor LUNGS - NOT EXPANDED 67061 647062 21 FD -21 FD LSUTNOGMSACH- N-OTNoEMXIPLAKNDEsDpor STOMACH - No MILK SPOT LUNGS - NOT EXPANDED. - Company Sanitized. Doos notcontainTSCACBI ww 9H0-2-4D5u1y6:GaSvuabgcehrSotnudiyc TinoxRiactistywith One-Generation Reproductive Exaluations - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F; PUPS DAM GROUP: VIII-0 DOSE: 250 MG/KG/DAY oANaIVAL PUP ANsIuMpAL DAYS NUMBER SEX NUMBER ON TEST FATE 0BSERVATIONS DuPont5386 643326 647046 21 FD SLUTNOGNSACH- N-OTNOEXWPILAKNDESDPOT 643365 647047 21 FD 643375 664477004443 2211 FFDD 7045 21 FD F 647063 21 FD SLUTNOGMSACH- N-OTNOEXMIPLAKNDESDPOT NSPOTEORMAIABTCONHNOERAM-LALNCIOATVIMEIISTLYK-DESTOCETACNTENDIBALIZED LSTUONMGASCH- N-OTNOEMXIPLAKNDESDPOT LUNGS - NOT EXPANDED 643429 66477006665 2-211 FFDD NNOO AABBNNOORRMMAALLIITTIIEESS DDEETTEECCTTEEDD U 664477006273 2211 FFDD NPoUPABANPPOERAMRASLITPIREESMADTEURTEECTED 67030 21 FD WPHUOPLEAPPBEOADRYS- PARUETMOALTYUSRTES, SEVERE - 647031 -21 ED WPHUOPLEAPPBEOADYRS- PARUETWOALTYUSRIES, SEVERE WHOLE BODY - AUTOLYSIS, SEVERE 664477003428 2211 EEDD WWHHOOLLEE BBOODDYY -- AAUUTTOOLLYYSSIISS.. SSEEVVEERREE 664477004590 3211 FEDD NNOO AABBNNOORRMMAALLIITTIIEESS DDEETTEECCTTEEDD 647051 "21 FD WPHUOPLAEPPBEOADYRS-PARUETMOALTYUSRIES, SEVERE 647035 -21 FD WPHUOPLAEPPBEOADYRS-PARUETMOALTYUSRIES, SEVERE 664477005534 -2211 FFDD WNOHOALBENOBROMDAYLI-TIAEUTSOLDYESTIESC,TEDSEVERE 647055 21 FD WPHUOPLEAPPBEOADRYS-PARUETMOALTYUSRTES, SEVERE 67064 21 FD WPHUOPLEAPPBEOADYRS~PARUETMOALTYUSRTES, SEVERE Company Sanitized.DoesnotcontalnTSCACB Tia 9H0-2.4D5a1y6;GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont5386 APPENDIX PP INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS -- Company Sanitized. Does not contain TSCA CEY Te 510.2-4D5a1y6:GavSaugbcehSrotnuidcy iTnoxRicaittsywith OnGeeneration Reproductive Evaluations Dupont5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS F; WEANLINGS EXPLANATORY NOTES Abbreviations SP = Sucrifced bydesig;necropsyperformed Company Sanilized. Doos notcontain TSCACB we 9204-5D1ay6:GaSvuabgcehrSotnuidcy TinorRiacittwyith One-Generation Reproduciv Evaluations Dupont 5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - , WEANLING amon avs NALE RATS GROUP: I-1 DOSE: 0 MG/KG/DAY MBER on TesT FATE onseRvATIONS 67051 1 SP No ABNORMALITIES DETECTED 6702 1 Se NO ABNORMALITIES DETECTED 67083 1 SP NO ABNORMALITIES DETECTED 667083 1 SP NO ABNORMALITIES DEWECTED 57085 1 Sp No ABNORMALITIES DETECTED 67086 1 SP No ABNORMALITIES DETECTED 67057 1 SP NO ABNORMALITIES DETECTED 667088 1 SP NO ABNORMALITIES DETECTED 67089 1 Se Ko ABNORMALITIES DETECTED 6700 1 Se NO ABNORMALITIES DETECTED 647091 1 SP NO ABNORMALITIES DETECTED ~ 670% 1 SP NO ABNORMALITIES DETECTED 67053 1 SP NO ABNORMALITIES DETECTED 67094 1 SP NO ABNORMALITIES DETECTED 67095 1S? NO AGNORMALITIES DETECTED "ompany Sanitzed.Dossnotcontainschcay 5 012-4D5a1y6:GaSvuabgeehrSotnuidcy iTnoxRicaittsywith OneGeneration Reproductive Evaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYS MALS RATS NUMBER ON TEST FATE GROUP: I-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647096 647097 47098 647099 647100 eer101 647102 647103 647100 647105 647106 _ 647107 647108 647109 67110 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - Jompany Sanitized. Doesnotcontain TSCA Cat =. 9204-5D1a6y:GevSaugbetrSotnudiyc TinoxRiacsistyvith One-Generation Reproductive Evaluations Dupons386 - INDIVIDUAL ANIVAL GROSS OBSERVATIONS - F, WEANLINGS nNoasEnR onoarvsest MALE RATS Fav GROUP: 1-1 DOSE: 0 MG/KG/DAY onservaTIONS S731 1 SP NO ASNORMALITIES DETECTED 7112 1 sp No AMORMALITIES DETECTED a: 1 so AmorsmuITIss DevecTED 67114 1 sp No AMOmGALITISS DETECTED 71s 1 sp No AmOmGALITIES petEcTED sa7116 1 sp No ANOmMALITIES DETECTED 7117 1 sp No AmOmMLITIES DETECTED 7:8 1 sp No AmORMALITIES DERECTED 7119 1 sp No AmOmGALITISS DETECTED 7120 1 sp No ABNORMALITIES DETECTED 6721 1 sp No AMOMGAMITIES DETECTED _ eamm 1 se No ABNORMALITIES DETECTED -- ~ompanySanitzed.Doesnotcontain TscA Cal we 9102-4D5a1y6:GavSaugbcehSrtoundiyc TinoxRicaittywithOne.Generation Reproductive Evaluations Dupont5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F. WEANLINGS ANOnMBaEnR oDNaTsESTALEPatReATS GROVE: INI-I DOSE: 25 MG/KG/DAY onseRuATIONS 67139 1 SP NO ABNORMALITIES DETECTED 7140 1 sp No AmORMALITISS DETECTED 6741 1 SP NO ABNORMALITIES DETECTED a7 1 sp NO ABNORMALITIES DETECTED 6743 1 sp No ABNORMALITIES DETECTED 67148 1 SP NO ABYORMALITIES DETECTED 7185 1 SP NO AMORMALITISS DETECTED 67146 1 SP NO ABNORMALITIES DETECTED 7247 1 spo AmORMALITISS DETECTED 748 1 sp No ABNORMALITIES DETECTED 67169 1 SP NO ABNORMALITIES DEFECTED _ 67IS0 1 SP NO ABNORWALITIES DETECTED 67151 1 SP NO ABNORMALITIES DETECTED 67152 1 sp NO AMORMALITIES DETECTED 67155 1 sp No AMNORMALITIES DETECTED S715 1 sp NO AmNORMALITISS DETECTED - SompanySaniized. DossnotcontainTSCACE I 91.02D4a5y16G:avSaubgcehSrtoundiyc iTn oRactskwith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS aL oavs MALE RATS GROUP: III-L DOSE: 25 MG/KG/DAY NUMBER ON TEST PATE OBSERVATIONS 67155 1 Sp NO ABNORMALITIES DETECTED 67156 1S? NO ABNORMALITIES DETECTED 67157 1 SP NO ABNORMALITIES DETECTED 647158 1 SP NO ABNORMALITIES DETECTED 647155 1 Sp KKIIDDNNEEYYSS -- SLMAARLGLE,, RLIeGFHTT; SEVERE 647160 1S? NO ABNORMALITIES DETECTED 67161 1 SP NO ABNORMALITIES DETECTED 67162 1 Sp NO ABNORMALITIES DETECTED 67163 1 5? NO ABNORMALITIES DETECTED 67166 1 SP NO ABNORMALITIES DETECTED 647165 1 SP NO ABNORMALITIES DETECTED "6716s 1S? NO ASNORMALITIES DETECTED 647167 1S? NO ABNORMALITIES DETECTED | 647168 1 SP NO AGNORMALITIES DETECTED 647169 1S? NO ABNORMALITIES DETECTED Company SanltDosisnzotecondta.in TSCA CB --_--_---m me 9204-5D1a6y:GevSaugbcehSrtoundiyc iTnoxRiactistywith OneGeneration Reproductive valusions Dupones86 ~ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WERNLINGS mTOmMBaE oNoaTrsESTALeE rRATS GROUP: TII-1 DOSE: 25 MG/KG/DAY osseRvaATIONS 67170 1 sp No AMORMALITIES DETECTED 677 1 sp No AWNORMALITIES DavECTED 6772 1 sp No ABNORMALITIES DETECTED 6773 1 sp No AWORMAITIES DETECTED 87174 1 sp NO ASNORMALITIES DETECTED 87175 1 sp Ko ABNORMALITIES DETECTED 67176 1 sp NO ANORMALITIES DETECTED 8777 1 sp No AmNomGALITISS DETECTED 778 1 sp No AmORMALITIES DETECTED 6779 1 sp No ABNORMALITIES DETECTED 64780 1 Sp NO ABNORMALITIES DETECTED ~ STL 1 5p No ABNORMALITIES DETECTED 6782 1 SP NO AMORMALITIES DETECTED 67183 1 SP NO AWORMALITIES DETECTED - -_-- `Company Sanitized. Doesnotcontain TSCA CBI 9102.4D5a1y6:GavSaugbcehSroundiyc TinriRcaittsywith One-Generstion Reproductive Evalutions Dupon:3386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS aNOoMBnER oNoarTsESTWMFEATERATS GROUP: V-1 DOSE: 100 MG/KG/DAY osservaTIONS 671% 1 SP NO ABNORMALITIES DETECTED 67197 1 SP NO ABNORMALITIES DETECTED 6719 1 SP NO ABNORMALITIES DETECTED 64719 1 SP NO ABNORMALITIES DETECTED 647200 1 SP NO ABNORMALITIES DETECTED 647201 1 SP NO ABNORMALITIES DETECTED 1200 1 sp NO ABNORMALITIES DETECTED 647200 1 sp No ABNORMALITIES DETECTED 647206 1 Sp NO ABNORMALITIES DETECTED 67205 1 SP NO ABNORMALITIES DETECTED 7206 1 sp KO ABNORMALITIES DETECTED 6207 1 SP NO ABNORMALITIES DETECTED 67208 1 SP NO ABNORMALITIES DETECTED 67209 1 sp NO ABNORMALITIES DETECTED 7210 1 SP NO ABNORMALITIES DETECTED - `Company Senltized.DossnotcontainTSCACB1 ee 9208-5D1a6y:GavSaugbeehSvtoundiyc iTnoRaittvith One-Generaion Reproductive Evaluations Dupo 5386 - INDIVIDUAL, ANIWAL GROSS OBSERVATIONS - F, WEANLING aWOnNoEEsR oNoaTrsESTWALFETERATS GROUP: V-1 DOSE: 100 MG/KG/DAY osservaTIONS 7211 1 SP No ABNORMALITIES DETECTED 7212 1 sp KO ABNORMALITIES DETECTED G13 1 sp No ANORMALITIES DETECTED 67214 1 SP No ABNORMALITIES DETECTED G7215 1 sp No ABNORMALITIES DETECTED 67216 1 SP NO ABNORMALITIES DETECTED 67217 1 SP No ABNORMALITIES DETECTED 218 1 sp No ABNORMALITIES DETECTED 647219 1 SP NO ABNORMALITIES DETECTED 647220 1 SP NO ABNORMALITIES DETECTED 647221 1 SP No ABNORMALITIES DETECTED ema 1 sp No AWORMALITIES DETECTED 647223 1 SP No ABNORMALITIES DETECTED Gm226 1 sp No AsomALITIES DETECTED 647225 1 Sb No ABNORMALITIES DETECTED - CompanySanitized. Doesnotcontain TSCA CBI -= H9-02-4D5a1y6G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANINAL GROSS OBSERVATIONS - F; WEAKLINGS ANTAL DAYS MALE FATS NUMBER ON TEST FATE GROUP: V-1 DOSE: 100 G/KG/DAY OBSERVATIONS san226 647227 sa7228 san229 SP NO ABNORMALITIES DETECTED 1 SP NO ABNORMALITIES DETECTED 1 SP No ABNORMALITIES DETECTED 1 SP NO ABNORMALITIES DETECTED - Company Sanitized. Does not contain TSCA Cay = 19.02-4D5a1y6G:avSaubgeehSrotniyc TinoxRiactistywith One- Generation Reproductive Evaluions Dupont5386 - INDIVIDUAL ANIVAL GROSS OBSERVATIONS - F, WERNLINGS aMBnEnR ONoarTsESMTALEFATREATS GROUP: VII-L DOSE: 250 MG/KG/DAY onseRvaTIONS 64722 1 Se NO ABNORMALITIES DETECTED 647260 1 SP No ABNORMALITIES DETECTED 647248 1S? NO ABNORMALITIES DETECTED 67205 1 SP NO ABNORMALITIES DETECTED 647246 1 SP NO ABNORMALITIES DETECTED 67207 1 SP NO ABNORMALITIES DETECTED 67208 1 SP NO ABNORMALITIES DETECTED 67269 1 SP NO ABNORMALITIES DETECTED 67250 1 SP NO ABNORMALITIES DETECTED 67251 1 SP NO ABNORMALITIES DETECTED 67252 1 SP NO ABNORMALITIES DETECTED 67253 1 SP NO ABNORMALITIES DETECTED 67258 1 SP NO ABNORMALITIES DETECTED 67255 1 SP NO ABNORMALITIES DETECTED 6725 1 SP NO ABNORMALITIES DETECTED - Company Sanitized. Dossnot contain TSCATRY ---- H9-02.4D5a1y6G:aSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproductive Ealustions DuPon-5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS aNDHAL DAYS MALE FATS NUMBER ON TEST FATE GROUP: VII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS san2s7 sar2s8 647259 647260 6ar261 647262 647263 641264 647265 647266 647267 _ sa7268 647269 647270 ar2m1 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 Se 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO AGNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI - = 910.2-4D5a1y6:GavSaugbcehSrtoandiyc TinoxRicaittywith One-Generstion Reproduciv Exalusions Dupont5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS anos oars MALE RATS GROUP: VII-L DOSE: 250 MG/KG/DAY MBER oN TEST FATE OBSERVATIONS 67272 1 SP No ABNORMALITIES DETECTED 67273 1 SP No ABNORMALITIES DETECTED 67274 1 Sp NO ABNORMALITIES DETECTED 67275 1 S52 NO ABNORMALITIES DETECTED 67276 1 SP NO ABNORMALITIES DETECTED - CompanySanitized. DoesnotcontainTSCACBI ee H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYS FEMALE RATS NUMBER ON TEST FATE Group: TI-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647290 647291 sar292 647293 647294 647295 647296 647297 647298 647299 647300 _ 647301 647302 647303 647308 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED = - Company Sanltized. Does not contain TSCACBI a. H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYS FEMALE RATS NUMBER ON TEST FATE Group: 11-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647305 1 SP NO ABNORMALITIES DETECTED 647306 1 SP NO ABNORMALITIES DETECTED 647307 1 SP NO ABNORMALITIES DETECTED 647308 1 SP NO ABNORMALITIES DETECTED 667309 1 SP NO ABNORMALITIES DETECTED 7310 1 SP NO ABNORMALITIES DETECTED 647311 1S? NO ABNORMALITIES DETECTED 647312 1S? NO ABNORMALITIES DETECTED 647313 1S? NO ABNORMALITIES DETECTED san314 1S? NO ABNORMALITIES DETECTED 647315 ose NO ABNORMALITIES DETECTED _ 647316 1S? NO ABNORMALITIES DETECTED 547317 1 Sp NO ABNORMALITIES DETECTED sa7318 1S? NO ABNORMALITIES DETECTED 647319 1 SP NO ABNORMALITIES DETECTED - CompanySanitized. Doss not contain TSCA CBI ww 01.-2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYS FEMALE RATS NUMBER ON TEST FATE Group: T1-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647320 1 SP NO ABNORMALITIES DETECTED 47321 1 SP NO ABNORMALITIES DETECTED 647322 1 SP NO ABNORMALITIES DETECTED 641323 1 SP NO ABNORMALITIES DETECTED 647324 1 SP NO ABNORMALITIES DETECTED 647325 1 SP NO ABNORMALITIES DETECTED - Company Sanitized. Does not contain TSCATBY -_. H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 -_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - 7, WEANLINGS AMAL DAYS FEMALE RATS NUMBER ON TEST FATE GROUP: Tv-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 47303 1 SP NO ABNORMALITIES DETECTED 647344 1 SP NO ABNORMALITIES DETECTED 647345 1 SP NO ABNORMALITIES DETECTED 647346 1 SP NO ABNORMALITIES DETECTED 647347 1 SP NO ABNORMALITIES DETECTED 647348 1 SP NO ABNORMALITIES DETECTED 647349 1 SP NO ABNORMALITIES DETECTED 647350 1 SP NO ABNORMALITIES DETECTED 647351 1 SP NO ABNORMALITIES DETECTED 647352 1 SP NO ABNORMALITIES DETECTED 647353 1 SP NO ABNORMALITIES DETECTED --- 647350 1 SP NO ABNORMALITIES DETECTED 647355 1 SP NO ABNORMALITIES DETECTED 647356 1 SP NO ABNORMALITIES DETECTED 647357 1 SP NO ABNORMALITIES DETECTED 647358 1 SP NO ABNORMALITIES DETECTED - `CompanySanitized.DoesnotcontainTSCA CBI re H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ana Days FEMALE RATS NUMBER ON TEST FATE Grou: TV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 647359 647360 647361 7362 647363 647364 647365 647366 647367 647368 647369 -- 647370 647371 647372 67373 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1S? 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - CompanySanitized. Does not contain TSCA CBI =. 9204-5D1a6y:GaSvuabgcehrSotnuidcy iTnorRiactiywith One.Generation Reproductive Evaluations Dupo 5386 - INDIVIDUAL ANTWAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYS FEMALS RATS GROUP: 1v-1 DOSE: 25 MG/KG/DAY NUMBER ON TEST FATE ossERvATIONS 67374 1S? NO ABNORMALITIES DETECTED 67375 1 SP NO ABNORMALITIES DETECTED 67376 1 sp NO ABNORMALITIES DETECTED 67377 1 Sr NO ABNORMALITIES DETECTED 67378 1 SP NO ABNORMALITIES DETECTED 647379 1 SP NO ABNORMALITIES DETECTED 647380 1 SP NO ABNORMALITIES DETECTED 67381 1 Sp NO ABNORMALITISS DETECTED 6738 1S? NO ABNORMALITIES DETECTED 67383 1S? NO ABNORMALITIES DETECTED 6738 1 Sp NO ABNORMALITIES DETECTED S485 1S NO ABNORMALITIES DETECTED 67386 1S? NO ABNORMALITIES DETECTED 67387 1 SP NO ABNORMALITIES DETECTED 647388 1 SP NO ABNORMALITIES DETECTED - Company Sentized. Doss not contain TSCA CBI - S134e516GoSnceoSnoesToxic ithOneGraton Repro Evans Duras os ows res was croup: Tr osm: 25 NO/KO/ONY Fe -- wim 3 er wo ssommisies pereoseD wis 1 sn asommisrss oer Fe -- - --_-- Company Sanitized. Doesnotcontain TSCACBU H9-02-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiactistywith One Generation Reproductive Evaluations Dupont-5386 - INDIVIDUAL ANTHAL GROSS OBSERVATIONS - F, WEANLINGS ANIMAL DAYS FEMALE RATS NUMBER ON TEST FATE GROUP: VI-1 DOSE: 100 MG/KG/DAY OBSERVATIONS 647406 647407 647408 647409 647410 47411 sara12 647413 647414 sa7415 47416 saa 6ara18 647419 647420 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1S? NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - CompanySanitized.DoesnotcontainTSCACBI ww. 2904-5D1ay6:GavSaugbcehSrtourdiyc TinorRiactistywithOneGeneration Reproductive Evaluations Dupont-5386 - INDIVIDUAL ANTAL GROSS OBSERVATIONS - F: WEANGLINGS ANUNMIBELR ONDAYTSESFTEMAFLAETERATS GROUP: VI-L DOSE: 100 MG/KG/DAY OBSERVATIONS 67621 1 SP NO ABNORMALITIES DETECTED 67422 1 SP NO ABNORMALITIES DETECTED 67023 1S? NO ABNORMALITIES DETECTED 67420 1 SP NO ABNORMALITIES DETECTED 67425 1 SP NO ABNORMALITIES DETECTED 647426 1S? NO ABNORMALITIES DETECTED 647627 1 SP NO ABNORMALITIES DETECTED 6472628 1 SP NO ABNORMALITIES DETECTED 67429 1 SP NO ABNORMALITIES DETECTED 67430 1 SP NO ABNORMALITIES DETECTED 67431 1 SP NO ABNORMALITIES DETECTED 64732 1 sp No ABNORMALITIES DETECTED 67433 1 Sp NO ABNORMALITIES DETECTED 743 1 SP NO ABNORMALITIES DETECTED 67035 1S? NO ABNORMALITIES DETECTED - `Company Sanitized. Does notcontainTSCA CBY --. 1902.8D5a1y6:GavSaubgcehrSotnuideyTionxiRactistywithOneGeneration Reproduce Evans Duroncs3ks - INDIVIDUAL ANIMAL GROSS OBSERVNTIONS - F, WEANLINGS mSOMoBER oNowTsEFSETMALAETREATS GROUP: VIII DOSE: 250 MG/KG/DAY osseruatzoNs 7448 1 Sp NO ABNORMALITIES DETECTED 789 1 so AmomuLITIES DETECTED 7850 1 Ss No ABNORMALITIES DETECTED rast 1 Ss No ABNORMALITIES DETECTED aras2 1 se ro AmommLInES DevecrED 67453 1 Ss No ABNORMALITIES DETECTED 47458 1 Sp No ABNORMALITIES DETECTED 647855 1 sto AmowmurniEs desecrad Gass 1 sp No ABNORMALITIES DETECTED 451 1 so AsomwITIES DETECTED ass 1 sp NO ABNORMALITIES DETECTED Gass 1 se No ABNORMALITIES DETECTED 7 ewast 1 se wo amsomuuross pemscrsp Gr461 1 Sp NO ABNORMALITIES DEFECTED asa 1 Ss Ko ABNORMALITIES DETECTED - Company Sanitized. Does not contain TSCA CBI _--------- 2904-5D1ay6:GaSvuabgcehrSotnuidcy Toxicity in Rats with OneGeneration Reproductive Exaluations DuPon-5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS ANDO DAYSFEMALE RATS NOMBER ON TEST FATE GROUP: VITI-1 DOSE: 250 MG/KG/DAY OBSERVATIONS 647463 6ara6a 647465 647466 647467 647468 647469 647470 arent 647472 647473 _ 647474 647475 647476 647477 1 SP 1 SP 1 SP 1 SP i SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 sp 1 SP 1 SP 1S? 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - EE Company Sanitized. Does not contaln TSCA CBI 9H.02D4a5y16G:avSaugbcehSrtoundiyc iTnoxRiacistywithOneGeneration Reproductive Evaluations Dupont 5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS- F. WEANLINGS awn avsFEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY NUMBER ON TEST FATE OBSERVATIONS 647478 1 SP NO ABNORMALITIES DETECTED 67479 1S NO ABNORMALITIES DETECTED 67880 1 SP NO ABNORMALITIES DETECTED 67881 1 SP NO ABNORMALITIES DETECTED 67882 1 SP No ABNORMALITIES DETECTED 67483 1 SP NO ABNORMALITIES DETECTED 6748 1 Sp NO ABNORMALITIES DETECTED - Company Sanitizad. Doosnotcontain TSCA CBI ww. 9H02-1D5a1y6G: aSgubeehSrtondiyc TinoxRiaciistywithOneGeneration Reproduciv Evaluations Dupont 5386 APPENDIX QQ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F ADULTS Company Sanitized. Does not contain TSCACE en 1902-4D5a1y6:GaSvuabgcehSriouidcy TinoxRiactistywith One-Generaton Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS Fy ADULTS EXPLANATORY NOTES Abbreviations SD = Sacrificed by design Duron 5386 ~ `Company Saniized. Dossnotcontain TscA cat we 19.02-4D5a1y6G:vSaugbeehSrtoundiyc TinoxRiactistywith OeGeneration Reproductive Evalustions Dupont5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F; ADULTS ALE RATS GROUP: I-1 DOSE: 0 MG/KG/DAY ANNUIMMBAELR oNDAYTSEST oDDEEATHOF OBSERVATIONS 647068 40 SD NO ABNORMALITIES DETECTED 67069 40 SD KIDNEYS - DILATATION, BILATERAL, PELVIS 67070 40 SD NO ABNORMALITIES DETECTED S707 40 SD NO ABNORMALITIES DETECTED 67072 40 SD No ABNORMALITIES DETECTED 67073 40 SD NO ABNORMALITIES DETECTED 6707 40 Sb NO ABNORMALITIES DETECTED 67075 40 SD NO ABNORMALITIES DETECTED 67076 40 SO NO ABNORMALITIES DETECTED 67077 40 SO KO ABNORMALITIES DETECTED 67078 40 SO NO ABNORMALITIES DETECTED = 647079 40 SD NO AGNORMALITIES DETECTED 667080 40 SD NO ABNORMALITIES DETECTED - Company Sanitized. DoesnotcontainTSCACBY oo. 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRicaittsywith One-Generation Reproductive Evaluations - INDIVIDUAL ANTHAL GROSS OBSERVATIONS - F) ADULTS DuPont-5386 MALE RATS GROUP: TII-1 DOSE: 25 MG/KG/DAY NAUNMDBNEARL ONDAYTSEST MODDEEATOHF OBSERVATIONS 647123 40 SD NO ABNORMALITIES DETECTED 647124 40 SD NO ABNORMALITIES DETECTED 647125 40 SD NO ABNORMALITIES DETECTED 647126 40 SD NO ABNORMALITIES DETECTED 647127 40 SD NO ABNORMALITIES DETECTED 647128 40 SD NO ABNORMALITIES DETECTED 647120 40 SD NO ABNORMALITIES DETECTED 647130 40 SD NO ABNORMALITIES DETECTED 647131 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS 647132 40 SD NO ABNORMALITIES DETECTED 647133 40 SD NO ABNORMALITIES DETECTED = 64713: 40 SD KIDNEYS - DILATATION, UNILATERAL, PELVIS 647135 40 SD NO ABNORMALITIES DETECTED 647136 40 SD NO ABNORMALITIES DETECTED 647137 40 SD NO ABNORMALITIES DETECTED 647138 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS - Company Sanitized. Does not contain TSCACBY w= 02-4D5a16y:GavSaugbcehSrtoundiyc iTnoxRicaittsywith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy ADULTS MALE RATS Group: V-1 DOSE: 100 MG/KG/DAY ANNUIMMBAELR ONDAYTSEST MODDEEATOHF OBSERVATIONS 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATERAL, MINIMAL, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED - CompanySanitized. Doesnotcontain TSCACBY - = 9H-02-4D5a1y6:GaSvuabgcehrSotnuidcy TinoxRiactistwyith One-Generation Reproductive Evaluations DuPont 5386 - INDIVIDUAL ANTHAL GROSS OBSERVATIONS - F: ADULTS MALE RATS Group: VII-1 DOSE: 250 MG/KG/DAY NAUNMDBNEARL ONDATYSEST MODDEAETHOF OBSERVATIONS 647230 40 SD NO ABNORMALITIES DETECTED 647231 40 SD NO ABNORMALITIES DETECTED 647232 40 SD NO ABNORMALITIES DETECTED 647233 40 SD NO ABNORMALITIES DETECTED 647234 40 SD NO ABNORMALITIES DETECTED 647235 40 SD NO ABNORMALITIES DETECTED 647236 40 SD NO ABNORMALITIES DETECTED 647237 40 SD NO ABNORMALITIES DETECTED 647238 40 SD NO ABNORMALITIES DETECTED 647239 40 SD NO ABNORMALITIES DETECTED 647240 40 SD NO ABNORMALITIES DETECTED ~ 647241 40 SD NO ABNORMALITIES DETECTED - Company Sanitized. Dos not contain TSCA CBI we. H9-02-4D5a1y6:GaSvuabgeehrSotnudiyc TinoxRiactistywith One Generation Reproductive Evaluations DuPon-5386 --- INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, ADULTS FEMALE RATS GRovP: 11-1 DOSE: 0 MG/KG/DAY. ANNUIMMBAELR ONDATYESST MODDEAETHOF OBSERVATIONS 647277 40 SD NO ABNORMALITIES DETECTED 647278 40 SD NO ABNORMALITIES DETECTED 647279 40 SD NO ABNORMALITIES DETECTED 647280 40 SD NO ABNORMALITIES DETECTED 647281 40 SD NO ABNORMALITIES DETECTED 647282 40 SD NO ABNORMALITIES DETECTED 647283 40 SD NO ABNORMALITIES DETECTED 647284 40 SD NO ABNORMALITIES DETECTED 647285 40 SD NO ABNORMALITIES DETECTED 647286 40 SD NO ABNORMALITIES DETECTED 647287 40 SD NO ABNORMALITIES DETECTED - 647288 40 SD NO ABNORMALITIES DETECTED 647289 40 SD NO ABNORMALITIES DETECTED -- Company Sanitized. Doesnotcontain TSCA CBI ou. 0H--2D4a51y6:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generaton Reproductive Evaluations DuPon-5386 -_ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fy ADULTS FEMALE RATS GROUP: 1v-1 DOSE: 25 MG/KG/DAY NAUNMIBMEARL ONDATYSEST MODDEEATOHF OBSERVATIONS 647326 40 SD NO ABNORMALITIES DETECTED 647327 40 SD NO ABNORMALITIES DETECTED 647328 40 SD NO ABNORMALITIES DETECTED 647329 40 SD NO ABNORMALITIES DETECTED 647330 40 SD NO ABNORMALITIES DETECTED 647331 40 SD NO ABNORMALITIES DETECTED 647332 40 SD NO ABNORMALITIES DETECTED 647333 40 SD NO ABNORMALITIES DETECTED 647334 40 SD NO ABNORMALITIES DETECTED 647335 40 SD NO ABNORMALITIES DETECTED 647336 40 SD NO ABNORMALITIES DETECTED - 647337 40 SD NO ABNORMALITIES DETECTED 647338 40 SD NO ABNORMALITIES DETECTED 647339 40 SD NO ABNORMALITIES DETECTED 647380 40 SD NO ABNORMALITIES DETECTED 647381 40 SD NO ABNORMALITIES DETECTED 647342 40 SD NO ABNORMALITIES DETECTED - Company Sanitized. Doss not containTSCACBY ww. H9-02-4D5a1y6G:aSvuabgeehrSotnuidyc iTnoxRiactistwyith One-Generation Reproductive Evaluations DuPont5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F: ADULTS FEMALE RATS Grove: VI-1 DOSE: 100 MG/KG/DAY. NAUNMIBMEARL ONDAYTSEST MODDEEATOHF OBSERVATIONS 64739 40 SD NO ABNORMALITIES DETECTED 647395 40 SD NO ABNORMALITIES DETECTED 647396 40 SD NO ABNORMALITIES DETECTED 647397 40 SD KIDNEYS - DILATATION. UNILATERAL, PELVIS 647398 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS 647399 40 SD NO ABNORMALITIES DETECTED 647400 40 SD NO ABNORMALITIES DETECTED 647401 40 SD NO ABNORMALITIES DETECTED 647802 40 SD NO ABNORMALITIES DETECTED 647403 40 SD NO ABNORMALITIES DETECTED 647404 40 SD NO ABNORMALITIES DETECTED --- 647405 40 SD NO ABNORMALITIES DETECTED - Company Sanitized. Does not contain TSCA ow. H9-02-4D5a1y6:GaSvuabgcehrSotnudiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5386 - INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY. ANNUIMMBAELR ONDATYESST MODDEAETHOF OBSERVATIONS 647436 40 SD NO ABNORMALITIES DETECTED 647437 40 SD NO ABNORMALITIES DETECTED 647438 40 SD NO ABNORMALITIES DETECTED 647439 40 SD NO ABNORMALITIES DETECTED 647440 40 SD NO ABNORMALITIES DETECTED 647441 40 SD NO ABNORMALITIES DETECTED 647442 40 SD NO ABNORMALITIES DETECTED 647443 40 SD NO ABNORMALITIES DETECTED 647444 40 SD NO ABNORMALITIES DETECTED 647445 40 SD NO ABNORMALITIES DETECTED 647446 40 SD NO ABNORMALITIES DETECTED = 647847 40 SD NO ABNORMALITIES DETECTED = - Company Saniized. Does not contain TSCA Cs: ~~ 910.2-4D5a1y6:GavSaugbcehSrtoundiyc iTnoxRiacittywithOne.Generation Reproductive Evalusions DRuepviosnetd.P5a3g4e6 APPENDIX RR REASON FOR REVISION NO. | - EE Company Sanitized. Does not contain TSCA CB REASON FOR REVISION NO. 1 `The following changes were made to correct typographical errors Tagen Pages 7 and 8- Tableof Contents, Removed sublitles that were inadvertently included for * Page 66 - A. Biochemical Measurements, reference to tables `was corrected to read "Tables 34-35." * Pages 105-122 - Header, Corrected study title and DuPont number. + Pages 131-174, 317-481, 629, 970, and 1281 - Header, Corrected DuPont number. Page 156~ Table 34, (p< 0.05) by Dunn's defined test." to "#" by adding "# the bottomofthe Statistically table. significant difference from control `The following pages were revised or added to reflect these changes; * Pages 1,317,629, 970, and 1281 modified to include "Revision No. - Title Pages for Volumes 1,2, 3, 1" and to update total numberof 4, and pages. 5, respectively were - Page 11- Table of Contents was modified to include Appendix RR Pages 1501-1503 - Appendix RR, Reason for Revision No. | was added. "Revised page" was addedto the headersofall pages that were modified in this revision. `The original pages were removed from the report and are maintained in the Medical Research file. rrr fe} Sn-- =-prea `Approvedby: ttl ( --pPe-205. wnt Revision No. | oigie5atnI/ Wos pSai n @onipany Saniiized. Does not contain TSCA CE" 9H0-2-6D5a1y6:GavSaugbesSotndiyc TinoxRiactistyith OneGeneration Reproductive Exausions QUALITFYOARSRSEUVRIASNICONE NSOT.A|TEMENT Dates of Inspections: Revision No. 1: 5-Apr-02 ReDvuirsoend:P5a3g5e6 Reportedby--:HeonbuQpuWalryyyABstBBr. absrrAouumseitor e _ 05-EADPR-003 Company Sanitized. Doss notcontainTSCA CE To --