Document 2JqbMvG7mN202bMbveaRawZMR

AMERICAN PETROLEUM 1801 K STREET, NORTHWEST JAMES M. McNERNEY, M.P.H., Staff Toxicofogitt Oiviiion of Medicine and Biological Science PLAINTIFF'S EXHIBIT INSTITUTE WASHINGTON, D.C. 20006 AFH44 (2021 833-S742 December 17, 1974 Eula Bingham Mattheis, Ph.D. Department of Environmental Health Kettering Laboratory University of Cincinnati Medical Center 3223 Eden Avenue Cincinnati, Ohio 45219 Dear Eula: The following items were discussed by the Carcinogenesis Research Panel on November 20, 1974 and we would like the oppor tunity to explore them further with you at my office on December 18, 1974: 1* Literature Review It is expected that this effort will not only assist the Kettering staff but also the Research Panel in giving direction to the overall program. Therefore, we would like to arrange a procedure whereby copies of pertinent literature would be sent to API for distribution'1 to.and study 'by 'the"'Reseafch' Pahel.' Meetings of the Panel with the Researcher during the study would include both review of progress and discussions on the future of the program. Although the literature review and preparation of a mono graph will entail a year or more to complete, the Panel would like the opportunity to review progress on the mono graph in its formative stages. It is the current thinking that the monograph will be issued as an API publication and the authors will be en couraged to use it as the basis for a review article published in the scientific literature. 2. Experimental Studies . Arrangements for the preparation, characterization, and storage of the petroleum fractions are near completion. It is planned that the fractions be retained within an industry laboratory where strict attention will be paid to safety and stability during storage. Adequate; repre sentative aliquots will be delivered to the specific contractors for carcinogenic screening and analysis. SC-API-4725 r r ( f r (' f" E. Bingham Mattheis, Ph.D. Page 2 Additional aliquots will be made available in case of spills, for supplemental testing, etc, at the discretion of the Panel. A best estimate of the requirements for the bioassays, there fore, is needed. The Panel would like to discuss and outline in detail the specific histopathology to be performed including the animals to receive post mortem examination and examination of site of application. Confirmation of all tumors should be made. 3. Administrative The type and frequency of progress reports and the location and frequency of meetings should also be discussed and agreed upon. It is the desire of the Panel and I am certain even more so, you, that we resolve all experimental design and administrative questions pertinent to the negotiation of a contract on Decem ber 18th. On the basis of our discussions, I hope to be able to prepare a contract and submit it to our attorneys for processing before the end of the week. Sincerely, Jl 9 J/aes H. McNerney JMM/p cc: Carcinogenesis Research Panel R.A. Scala, Ph.D. ^f J) Op/ 3