Document 2Jd8nXar4Ne1OJLrjMpZxB6e7

OO C=fl Industrial Hygiene Digeat February, 196 129 Treatment of Coronary Atherosclerosis with Linetole. P. E. Lubomsky, V. I, Bobkova and P. M. Savenkov. Klinicheskaya Medistsina No, 8, 68 (1960). Russian. Linetole is a preparation consisting of ethyl esters of linoleic and linolic acids ir the same proportions as these fatty acids are found in linseed oil. It has been prepared by the Soviet Drug Industry at the request of the authors. A daily dose of 20 ml. was given foi 20 days to 50 patients with known coronary atherosclerosis. In 10 patients it was used ove; longer periods of time. During the administration of this agent the cholesterol and beta-lip protein levels in the serum dropped and in the intervals when the administration of Linetole was discontinued these rose gradually again. Patients noticed marked improvement in thei general well-being and a decrease in anginal symptoms. -- Can. Med. Assn. J. Absti 130 Verrucous Carcinoma of the Buccal Mucosa in Tobacco Chewers. K. Sorger and J. A, My Can. Med. Assn. J. 83, 1413-1417 (Dec. 31, 1960). Squamous cell carcinoma is the most common malignant neoplasm affecting the oral mucosa. Such tumors may present considerable histological variation, but the majorii are only moderately well differentiated. They are frequently preceded by leukoplakia. Sy philis, dental irritation, smoking and the Plummer-Vinson syndrome are recognized as fac which probably predispose to oral cancer, More specially, in carcinomas of the buccal mu cosa the chewing of betel nuts as practiced in many countries of the Far East, and of tobac including snuffs is considered to be an important predisposing factor. In the great majority of patients with this verrucous type of squamous carcinoma a history of tobacco chewing coi be obtained. The present report deals with 4 such cases of verrucous carcinoma of the buc mucosa which were encountered in old men with a longstanding history of tobacco chewing. J view of the fact that this variety of oral cancer carries a much better prognosis than the mo usual squamous cell carcinomas of the mouth and since a 1- to 7-year follow-up is availablt in 3 of the 4 cases, it would seem to be justified to draw further attention to this lesion. Th need for awareness of this entity and for its separation from the usual type of squamous car cinoma of the mouth is emphasized. -- Can. Med, Assn. J. 131 Immunization, Antibiotics and Surgery in Wound Management. O, P. Hampton, Jr. Ind. Med. b Surg. 29, 553-555 (Dec. I960). Precise and thorough wound surgery remains the most important preventive mea sure against all forms of wound infection including tetanus, gas gangrene and pyogenic woun infection. Only against tetanus are biological products effective in producing some immunit Active immunization with tetanus toxoid is far more valuable as a preventive measure than passive immunization with tetanus antitoxin. Antibiotics may be valuable at times in preven ing wound infection of all kinds but only as an adjuvant to other measures, -- Author's summary 132 The Efficiency of an Ethylene Oxide Sterilizer in Hospital Practice. R. Znamirowski, Shei McDonald and T. E. Roy. Can, Med. Assn. J. 83, 1004-1006 (Nov. 5, 1960), Dried preparations of Staphylococcus pyogenes and spores of Bacillus cereus wer used to test the efficiency of an ethylene oxide sterilizer. When used according to the manu facturer's instructions, exposure for 2 hours at a temperature of 130*F with 2 cans of gas giving a pressure of 12 lb. and with 30 ml. of water in the reservoir, the machine failed to sterilize micro-organisms dried on glass. Some staphylococci dried on glass survived trea ment for 6 hours and spores of B. cereus on glass survived 18 hours. Sterilization was re markably better when the bacteria were dried on absorbent paper. Future improvements in the design of machines, especially for the control and application of humidity, may lead to effective ethylene oxide sterilizers for practical use in hospitals. -- Authors' summary 9. 03120741