Document 2JNVnOEBVpmzOjx1bLpYjZwr5

booi Stan Shaw DaoaUbar 7, 1967 Nr. Oaorgs Abbott Pannsalt Chanloala corporation 900 Pint Avanua King of Proaala. Pennsylvania 19A06 Daar Nr. Abbott* Tour lottar of Novanbar 10 raquastlng Ufa handling lnfomatlon on our haat tranaTar liquid, Thaminol, baa baan rsfarrad to aa for reply. Tha following diaauaaion undor spaelflo handings will, Z hopa, ba halpful. 1. Toxloltr Data Tha aout* oral toxlaltjr in rata for Tharnlnal PR-1 and PR-2 la approxlaatsiy 9 graua par kllogran and 12 grans par klldgran respectively. Whan appllad to tha akin of rabbita, tha mini--latha1 doaa la approximately l gran par kllogran for althar THHWZNOL. Xt la not unuaual to aaa grantor sensi tivity In tha rabbit with this tjrpa of uaterial. Aninala of arranl apaolaa (oat, guinaa plga, mice and nta) survived without signa of Intoxication whan axpoaad to air ladon with THSRNXNOL PR-2 for aavan hours par day for four daya. Tha oonoantntlon of tha vapor waa naintainad at A3.1 milli gram par oublo natar. Inhalation of vapors at this high oonoantntlon cauaad a wild non-apaelflo pnaunonitla. Than waa sona avldanoa of ayatanio toxloity but nloroaooplo pathology ahowad thla to ba nvanlbla. 2. Detrimental affaota on oaraonnal rssuitlnn fron ovaranaoaun No sarloua aouta datrinantal affaota on panonnal would ae expected during tha nonal handling and uaa of thla fluid. Tha vapor oonoantntlon whloh night cauaa nauaaa, vartigo, a tanponry llvar danaga an so irritating to tha ayaa, noaa, and throat that workam would not ba axpaotad to voluntarily subject thanaalvaa to such an axposun. Squally Important, howavsr, la tha possibility of ayatanio injury resulting fron day-in and day-out ohronio exposures - althar by vapor Inhalation or oontlnuoua skin exposure. MGNS 090384 Mr, George Abbott 2- Deoeiaber 7, 1967 3- Symptom of ovr axpoeure In addition to the items mentioned In (2) above, prolonged and repeated akin exposure to tha fluid may result In a solvent action on tha akin followed by drying, ahapplng, and 0racking. If tha axpoaura la sufficiently great and prolonged sufficiently, ohloraene may develop. 4. Maximum allowable concentration. Tha maximum allowable oonoantratlon for THURWHOL yn-l la 1 milligram par cubic mater. In the case of TBB3D0DIQX, FR-2 the suggested maximum allowable concentration la 0.5 milli gram per cubic meter of air. Summarizing all of the aminal toxicity data and many years exper ience with this type of chemical, our evaluation la as followai 1. The dally use of this product In recommended applications present no hazards when one follows the recommended precautions, such as the use of the medium In a completely aesled system where there will be no leakage of liquid or the vapors when the material Is heated. 2. The loss of fluid at a high temperature or by being sprayed onto heated ourfaoea (as the result of e broken line) pre sents a hazard to humans no more critical than with other type fluids. In either event, the vapors or deooopoeed pro ducts would be so Irritating that workmen would not remain In the contaminated atmosphere without respiretore or gae masks. In those Instances where breaks have occurred, exposure to the workers long enough to shut off the system and evacuate the premlaea haa not resulted in any ill effeota. 3. Skin oontaot with THSmUKOfiS at normal temperatures does not present e hazard In terms of Immediate or subsequent systemic effeota If normal personal hygiene practloea are followed. In other words. If thsre la maaslve akin axpoaura, workmen should, within a reasonable time, remove contaminated clothing and baths thoroughly. 4. Repeated or prolonged dally akin oontaot should be avoided in order to prevent possible irritation to the skin and possible systemlo affects. Again, normal personal hygiene should suffice as long Is 16 la understood that workman must not amsar tha liquid on the skin end allow It to remain. MQNS 090385 Hr. Qeorge Abbott 2' December T. 1967 If after reviewing the above Information you hava other apaolfla (meatIona, plaaaa lat me know. Very truly youra. EPWioJa Elmer P. Wheeler Manager, Environmental Health MCJNi. 090386