Document 2JK6bB9q5GgXDd3091Epk9n8g

MISCELLANEOUS REPORTS OF EXPOSURE TO TEL - I NDEXED AND SUMMARIZED (FRONT OF FIL E ) -\ ! f ^ 0017214 N21008 N .) F. 3 -ho f i r s t vary iill rep p rt o f .t l s Os s e iitio o '.as presente! Aurjust 20, 132-4 'i-iico t e s t t i ne, isis o r.s h o r t s bave been ., 'rosoiited dealn-:? *'itb th e s t iv i t io s s f tao OoTscsitte 'Thich baa siv sa uarotaitting stady to tao probleras involrod* '.` g follotsiag j*eport p ressa te a granaary o f Faysay and tayton case 8 o f poiscatng to late v.lth ofher sm ttors to d ate -o f isaportsace and i3.t-3r-33t, tsitb tha exseptioa tb a t no fonasi s t a t i s tio a l rsp o rts thna f a r bava 'neon o ntainablo fresi tha dn ?ont p ian ta iA 0017215 'toavalesasnos' ayton Cassa ' Oospmter Cassa ";is a a a tlia g hnsifaeats "ttmus Cas T2&parfasatg ''sasds of Esposta? a i tlia Ba^Ksjr P l a s t . I&saflg of Jirposu? a t th iaytoa P lant "xsards o f lOsposars a t f aew im ild iag 02 ths du font :rxa&ar of cases o io ls o sia g ' .`rutbo? of asaths lta&s* of cassa o f sali symptoa obsanred la 3 P atient `.Issearoh lasearalMS seissg Prsscutsd a t Dayton Syaptoass as produoed >y ffe ro n t types of ospossnea Tr&atmni employed Paytea as pbjrsicaa* fhere XTQT& a@ cases fre n A ll toM. tSa: oass ra p aro no easos a t p re ss t a 13 oases snc Ootober g t - a "T? r)t? 133 Pota! reporten caaes* At; 3s^vmj :.t Peepsater S \ t Aaysoa 2 ~ -O:.vi * )'^ t V^-O-P^ |M ?rrabr of removerles tuaiber a asea retaraad te noresal o r p a rt tia e wrle tuo&er who jsore l e f t th s sarrio o f the osnatp? Tuaber. se a t to Iiospitals 'usber treafcad a t ham QA5^3' ' KE 0017217 i .TtsaBor sent to h o sp itals :irab9*'. tre a te d a t 1%.. nosa a ll HE 0017218 Lersfeusnesa F ro stra ti cm Vertigo 3y#iass ITausea .r3 s i t i a g : vnorefeis. ' 1c astig a tio n Liarrhoea F airs t Lry Louth. , Looturla Fains la groins ..Memlnal gain Other gains Letallie taste loss sf weight Law olood pressure 'Low pulse js liriu s 3tppIIag lead la stools Lead! i.'3i u rin e Lo^yfeS; temperature "Lypsyasiaity Acetone .M'oi-sca Skin to st Tremors Scotoma increased asssular reactions Ifalargcid p u p ils Itching ISocous :a32fl>att0 i r r i t a t i o n SOT'Ss Lot a l l these p a tie n ts had th e -urine a s m a t and sto Among 29 p a tie n ts whoa sto o ls were examined, lead as pre m s examined'in 3 eases and lead 'as p resen t i a only one c Instances in which lead-m s absent. t r m the urine i t 'm s p e 001721-9 - 1 th is syrapto* ."boat one-half the p a tie n ts esaainsd a t t Hospital also slowed it when th e ethyl, ch lo rid e process b y .the' ohssdsts a t Bayaay* they f e l t q u ite confident t i a t hazardous than the ethyl broaside-process* hut a n im ls pois in osporiiaente .mads- f o r the Consalttes a t -Baye&y* showed th to he the case# moreover* a t the du. Pont p la n t th e o rig i 5iicaltansously conducted while the sewer etlgrl chloride pr i t Tsa in the l a t t e r work th a t the recant sudden out-break Hha wall-known stim ulating e ff e c t o f in h alatio evident i s setae o f .the ssor&sam?. tM t is sasa who were perh a l i t t l e out of sorts* would fe e l tem porarily b e tte r whilo i f they gained sou s lig h t e x h ila ra tio n frost trac es o f tea oa going host they would collapse again, Hsn working on to su ffe r more than those eiwloyed during the day* in many , At Dayton, w ith the reduction o f exposure to t g re a tly decreased rat o f -absorption o f lead, there ha clin ica l, p ictu re p f .the. poisoning 2h su b jectiv e symptom pronounced form* in fe a t, in some cases they do not appear lead aosarptxoa have put xn t h e ir appear.snae^' la several p la in t Ms "been made, i t has been p o ssib le to fin d s lig h t Kf 0017226 Of 'polgoalng "befora ti snbject i s sonsciou o f aay ilin e i t seas li& sly $ t ti danger o f aay profemofeai. illa s s a Saytoa p te & n s s r b e 'overeme- eoapletQly A p rao tio e i a a l l ospo3ur oa j eaploys wlo sbswg nay o f t s i g is o f l sigas uhieh appaar 'as as folloas*. SligM drop in bloo fessaperstur#. alow p a isa , aa occasionai stip p lsd ery tb ro ey blood oorpusale} in ti blood* S^mpteiss aay o r iaagr a o i slighfc drop in ti blood pressar and tasposatare i s no sabeot Isas a- col or say o th sr iafeotio-os or o th e r iataed in. fe-.-abi3m,.of tbea tMags# and i ? ti gtdm i t is considerad sa fficiont cause fo r oessatioa of esposa stip p lia g a la o s t invariafcly appeara*.-, Ita apearas , td otaar sigas, is osasi dorad aa inaieation of load absorptio t appearanc o f d e fin ito syaptoffis o f sleeplessness or o thsy osear i s core tban ta s nost fle e tia g jaanaer, i s alwa Ooayalesoeaa u su ally lias besa proferaoted and mr abl to b up aa laalSdng sbout* tbay nevertheless f l a reg a lala# a p p e tite and '5igh,t* In su m a ais *s a u loi? blood pressore# . 2b psyoilo g ic a i ffeota of ts disasfeor afe ablB study afe tb e Beoastruotion H ospital,, l a general# intionfes vo ,mm&- VQvZ\tm genuine syaptoas isfcila a t Im H M* A D i . 7 2 3 1 ( ...... apposi te GS&tral 96a8Ct tiare gir- ato? tms ri & es, a-radi t h si r use,, aia! th-generai afcassphsr of caaer i a ih asti f asta? i n stortsnin?? tha ti rati sa of i l l aass* - k~?irm Gpyssgg Dodtsating th daaths Sfoa t3 sarsaty-eaa -i-t Eapsafv ti sre r i s a ia sxty~sx t t i s s a t ir o aaaljor IQth, 1923 - asarl y fl? e laoatas a f t e r t l ori gi nai poi soaia -tay incapasitatcxl aad Ma sj^etoias vmr p ra e tic a lly gone* xar sfere ao parssaasat'l assi si o r pBysioal sjssptoms ssyorii o f load ?iay s t i l i preja'blsr s foaad i a tfea sfcools of a few im iuare occasionai g a s tre dsturianees*' A g re a t majorit non V3.V "man. rotnrasd feo e lth e ? f a l l or p a rt tira woVkt, vario roasona* l o f t tso se rb ica of tfes Oosapany*, la. pattante, fcayag.isiia m a doeide lea?I s t a r s i in tfee fcody eould b caused te a exeretsd fcy p fo ti i i s ad, calcitai o h lo ria m s givea, fcllo sed hy Mearfe soaa ossea .tM s seraed te inorasse tfe load output*. In a l l iha p ati ests sta d i d, th ehiaf sotiro e o round to sb through ih howals*' A lthon^i l ead m s fotcad xa t'ha a rin e , i t of tea i absent irosa th a t sm retion. wM lo Although th irte e n deaths were recoded only oughly scse* l a two o r throe i nstances l a coaaactioa w i autopsi es wars amde^fy; o u tsid e a u th o ritie s , which nrorsd of vary l i t t l e sci en ti f i c value I n o th er cases, permi refused*. ?ha f our accurate autopsi es were made by Sr* C Medical Usssaiaer of Sew to r t C ity, upon p a tie n ts who died Hospital* Tbs gross appearances i n th ese cases only hav f or the oheetical and aioroscopio exasainatiems requi re sev completion* 'ihe hedical Ssatainer 'i s ' exceedingly busy and ef f orts ..have-bean made--to hastes th i s work, i t has not y e Hxaasiner stated th a t one of the fo u r pati ents presented no the autopsy fra a which l ead poisoning could have "been diag tejwlotdge of the man's occupation^ I n three other pati en characteri sti c f i ndi ngs were as f ollowss "Sxtreme conge srueous xnadbrassa* and the luags showed "extreme congestion The bloodvessels oa the surf ace of the br si a showed " i nten outer l ay er of brai n substance showed "sm all hemorrhages" congestion of th e abdominal viscera#, I n one case there w appearance of the muscles, in one ease, blood was presen I n three pati ents the causa o f death, m s given, as `'HSeforr I n the f ourth case, i t ran given as "Cleaeral V isserai Cong case in which th e p ar ti al chesaicsl anal y si s has been comp q u an tity of load -mg found i n the brai n substance*-said to hal f grains* . ` ceedingly obstnate althaugh a great v a rte ty o f bygadtios thass provittgl`T?ithottt '0t sM. msTpM.tm p a rte ttia rly m s Parslfiofea and sim ila r,draga piso mere wXl-ngr usele&s* 119 to tija exaessive individual dosag o 90 graina i th p a case.s' # la ose case o f v io le' n t d e llr lu a tr e a to t a t tbe d a s givea hg^odessaatically w ith started re lie ? causing slesp hours* Thm the s?&tam stbseqxtently recorred ia tisis p 3at was agaia effective, Tha aM osiual pains vara rello saat "and:such' remedies a s cadein w ith vacuation o f tija ho To promote elim ination#. the p a tie n ts -ver enco q u a n titie s of fluids* pl ai n m te r# lemonade# m ilk and vichy w ra strongly evacuated vdth saline cathartics#' Perspir m a te and e le c tr ic l i ght baths# To the p a tie n ts at tha Pa sodium thiosulphate m e given by in je c tio n i nto the veins,* extensively used al so i n mercury poisoning to promote elim tha pati ents tr eated a t 't h e Beconstraction Hospital i t see value# ' ' A lkalies such as soda and magnesium sulphate w supposed acidosis, In tha m ildest cases th e only treatm ent followe patient from fu rth e r exposure to tha poison and placing him abundant fresh a i r and sunlight w ith moderate exercise#- ieno th a t patients- w ith mild ya&toas. oho were kept i n bed K f 00172? 1 'X Tr\ J- fa eM* 9 Ivf- o % C3 g moots ? oH0t CS i I & if t 3? 3 *3y c;w;* fcsi** *cf u 3- 3 4 $ ff- * et SI S fo eKt* o1 et 'te ^MC ,eej o^-2 -02 ats-CQ- soc,s tT xaA^$B^&</?@$r.O0 axs&ju sis?, t&. <zG$ aopq.ri3 g e *zTs vado .' s s a h ; p ano S g%psSte e arn cxps. m m s V. ystima tSa*Gwgh th t e s t o f ih p la a t to g a i to th e i r ,mTkr '; th eseapiag ftssas ca a e re ra i ooe&aions ttMc i f i l i s i th s pl&nt also* th anto el&ves w r e f i l l s d mith laad allojr fzma te a -f ti abavo th fido? fhs propese vas reyy dusty s a i re a d ily ra s disseminatesi*. Several so -c alled '?blewmtsMo aal&ng it'a e o e s a a e y fa r a l l th sa to rosh o at o f tha h n lM s o o e ttae s fos* tro o r thsee Smura befo're a l l tra s s e o f odor be rm orod * 2hare miao vaarteus ocsaeions vfhen s p illa oosra opportuni t y fo r SJdn, oontaot tsdth. te tsa e th y i lead. Owing o h araetsr o f t l tsexl? i t - m e -injpossible to detesmiae frost t bea* ospoaecl J n s t t had bee a t fa u lt fo r @mh p a rtie u l *s* rario u s so n a; fallar o f o o ustaat ae o f th p ro te o t beea raoaaajended by tha fefiieal. Dep&rfcaeafcf m&mm m m Ott tl oeoasitm o f th dlgtaa& tlng o f th Bsyva partoent orderad tba-^gtststst prteotit eastarea foy th - elad.- l a r ^ b e y fkoa head to f o t a n i th atrs p la a t -was t lth m te r to allay k isstgfr-gm o f aja ar a s s i g i t m s asM notS.-nteagively disilo a tx io t stgtsrvision .vs jj s-olt tliat no tsmbX of say s c r t -folloved^ KE 00172|6 valves and th at in -th e process o f emptying the load allo ch lo ride vapor was released in considerable qu an tity thr end o f the autoclave Too much relian c e had been place ion o f v e n tila tio n and the raa t hero fo r had not ro ra ssis Sixteen autoclaves fille d tvds sash clay asid a t varyin Therefor th e re vac the p o s s ib ility o f soaps o f tftyl o containing traces of te tra e th y l lead derivable from sixt openings . The vorfcmaa i a th is process vfor no masks*. o f the building are separated, only by as interrupted flo scaping vapors might-.-be. eommsa to both floors#) Inasm more d i f f ic u lt to confine than steam, unusual tig h tn e ss e tc . must he secured^ m z iim z OF 1SP03TJRH AT Tm m YTm PM1T 1. F i lli n g drums -with Ethyl flu id 2* h a sh in g drums. 3 Clea n in g and d ecap p in g sm a ll cans- in vSii s h ip p ed *- (Hazard h er e from in h a la 4 An a ly t ic a l and exp er im en ta l vrfe on t e t r a ESjgX. Th f i l l i n g o f small cans o f Ethyl flu id and th heoa completely discontinued, thus elim inating most o f th w ill'now b no appreciable exposure to the dust of tr f - e t Bu r in g t h e p a st, seven aka ( i s p r io r to. A a t c-ayton h ave bean v e fy m a t e r ia lly r ed u ced ^ Th is i s a these- operations required the esployaent of a considerable s u tM s .operation discontinued fclie s itu a i danger*-'-of esposero Isas aat-.tiio avEnbav-Qf-. ft^loyoes. also lias been reduced^ The hazards which now vernala to ha considered are 1*. The f i l l i n g of A m i of ''Sfchyl" fluid, Oda i s v en t i l at a rosa. Tha consti to sa ta ara pipaci ia to tM s rooia i n aay m y b j th sasployea^ Thoir ai i v ery l ato th Qrm i s m t i c f i l l i n g devices wMch radoea tea p o s s ib ilit of spi i l&g a Tsnisrorn*, 2v The unloading o f tetra thyl lead la to Storage tante aecopl3ld i& th a m iniasi esaunt of clanger fro siq>asur* o f vaporB urhich s ig h t b `had*. i s preyonted by th ose of Basic 3*. f&a wasMng o f' druns SMa i s being dome in a sp b r issane of autosaatio raacMnery ojyl appesaci to he a saf pro 4*. A nalysls of tetrathyl lead^ The picesa wlich sin g le :cha&st*;i involves a sllg h t assrant of'scostar#; SO!- months ago a greats number of sm all'pumps whi Bayton fo r dispensing the concentrated fluid; were returned to a t t e s t to clean those quishly and get them out of the vay,, a poisoned. by the in itia tio n o f the dust o f -t r i- e th y l.lead s a lts Operation carried out fo r a l i t t l e jaora than q meSe brought ab o f the cases of poisoning uhich have occurred In Bayton sino : . a te r s ia SS cases o f puisoaiag"' b ^ a ss 111* ta t 'ter '- ".v 'piosssrat tesaos o f t te dicoovexp o f s i^ s s tir s sig a s o f 1mA :V ' ata aot- los tiiasr Isst'iss? Itter released er trsasferred t o f tt e eigh tesa fser miAovmlj 111! tte u ^ a rw o f itea ted es for ssramL 'm^3. s t a tim* . piggarrogiss g s m i s m iaj> f i a Goamlttee te s feaaolated e s i t o tad oapr to a l l esployeos Im iling tetraeiljgrl lead i a txanspo'rtatioft eliv e s^ taaK"'raagaB: si&#v H rinted pstera o f a araia g a ls f U l i a g a tn tio a a sa aay ca puroBasi&g t l^ l gasolina i s f a earfi o f v zrzla g a g aiast i t a na fo r say e t t e r paspaos t te a t motor fuajU, Oopies o f ttes rul@3*! reg u latio n s aad -ssasnia r@rt* fh s IJedisal BepartsieBt of t t e Standard Oil Compaq ssr sploys a special in sp ssto r wte ls . Borretod fresa -tte se Burean o f M aas and irte- t i e i t s a l l t f i l l i n g sta tio n s v&mF st^ p lied # HO matea metegr re p o rta to t t e U sosl opertese feines x d th rM c h t t e r a l e s ' &m srrief out isn"rep o rta -.eag e r fallar to. otear? l l t o m l l y t t e r a l m &n& r^fiLations !m-@ Besa B s n m tly sa.tsator^ and n ' sa eta o f poisoaiag t m & m n m 'm . . ^ ;. .. Tte snperisssnts in s titu to s 1>y t t e oamitta i a t M iteratorr o f Qlimbla m xi-retty nade ''Hrofessoy p ila n and ... i S Sasoline* S ii objeet has beea Icept s t r i o t l y ia Mn alt any acisn tifio features of th snbji Mob are of-oollat ona o f tM la b o ra to ria s i s y a t saay to saka a f in a l rep o r e stab lish sd thua f a r th a t d a ily sk ia coatawt of Sfciyl Gaso fow tseaks i s eapable of oauaing stadi aegre of te tra e th y l l sajr bs deteradned la- th stool o i t h e an ln als esperiarm ted already bave shoca syasptams o f ehroalo lead poisoniag* I Contai tte e , ans tM s f a e t d o fin ite ly i s estahlished th a t i cufce tM s lin o of exporiiasatation farth er D e ta ils o f the d iffe re n t anjssals In relafcio to th srfaoe ezposed tl-sei detemdue madama and minia* dosage a re ia ts r e s tia g s o ia n b applied to t e s a beings*; fbs trcie qaostioa is vheth and storsi. in tiie huaaa System ihrongh proloagad o r f&ocpxe Gasoline, flaoe th a t f a s t i s determ inai i t m atter l i t t l e how such o r 'sjw l i t t l e lead i s absorbed, o r over how larga - z j y j m gas gcraen With ekhaust .gas, - experim nt ere in s t itutad b Olierai cal Gorspstay bsforo th thyl Gasolin o Coramitte tv;j.s ap connoted fo r abcmt a year*. A fter o ig i m a t a of aspert ra s i astisi by the Bureau of id n es^ p ra o tio a lly sosplefceXy e sny hssard fo r th publie> H overtheless, th ere i s a .grotr K 0017231 o f ob vatiea have been mad oa # 0 th a t lead i s t both i ' " nvt**-* it;|s ls lw i % , t e gasatiti varying from a f , up t 'f t y- for-, a te ty -fQ u r teu ? period*. excreted t e 'tb s w rite exceeded te a t in t t e t& m m fo r a co ;t e a l l o tte r s t t e q u a n tity aerated i a t i e th a t ia t t e urta* Sommimi Inadequate* (te sa sse incomp on t t e infissa o f -tarioa# s a l ts m . t t e s r s t i o a o f lead oases tte a ^ n is tjm tio a . Of m im . bicarbonate ia a dosags Increased t t e quantity c ra te d ia twenty fea r tears f o f se cre tio n varied frost t h i r t y to f i f t y neraeats-/- In on tte ' ' dacedf. In/oae ease in which i t vas e^Ieyes* ' c a l c i ch f if te e n grassa daily*" increased t t e se cre tio n o f lead i n bo almost double i t s former quantity. - . . . : . , ....... ~i . 1 each failed to increase secretion* I a on cae# sodium . ^ p s r te e a ta tio a both i a rasa and in anmala t h t f lin e * I f s e c r e t ! c m be obtained m& ssiat& iasd a cum ulative 'e f l^ t 'w i- be produced by lead* a t least," ia - " ; '' ' d irect medcei control*, rf t e Busard froea E thyl a s s o lin e ^ 'K ' x,r ' -- - ' . considerable number and v a rie ty of anima ten the hasard fm m t t e above source^ Experiments are KE 0017232 Suissitte foy the f a t r a e t ^ l Lead osirditea W Dr* W* S d lm a .topsn* _GMi*sssa /v / f ad Br* Robert - Ke'oe%, i ..... 0017233 SL'* j4 P ,