Document 2JEQy7ExeKMoXm1zZQMexEJ5r

FILE NAME: Talc (TALC) DATE: 1963 DOC#: TALC003 DOCUMENT DESCRIPTION: Talcosis References N zCL -Nw o \A i ^ NC SC O t 3 cC E- 5i 1 3 CO o u- N > 3 O. D . *-i Z 2- s3 Nw o rt .55 -C <u O ^ M` ^ N ' v o O Q ija 0co) 2g GS 3l "M3 O o .5 X! C- O ^u .O i C fi J 5 a = ^_ c t .c >* *3 ~C ' 3H1N3) NO'iVWJjOdNi H11V3H 0N Aiddvs iyN0iivdn3)0 ivnoivnssni Q I O i DGA 34-1964 CIS 1812-1964 Fsh G tz M pz -a obe O . Li ~ Uai ai ' gh tO< <cNi co < . ' x ^ art i^ > hqr. '; bOo "- aS- w 5- a J- -o "C Q3 ri I b ig p -c ^ a w wa C s> 5 ^ i cn co u JQ c0) " 5 p-1 ^ ac o <d --ai i x ; . et iC^ b0 Q`ti 3? 43 3 In a o,, ^ ;j a e " _ a io os ; 0) .QJZL " -3 U - - i) '|-' |CC_'-e> O 1 f f i i .ne 1^3 CXD ;* ri fMi Tr!t ) a co 2 5 w bo 2d S 3 1 s ic ' , XOJn*a5 | -- rt 52 c-o X-OtiXe -Q^O f2"t Sfrit O^ J-3>i; re: l0 g2 o 2 -e bc 2 3S1N3> NOIlVWHOdNI H11V3H dNV AJJdVS lVNOIlVdnilO IVNOIiVNdllNI O B O I %J Na. O Ah w S O ; `o _r i 3 O 03 sco scu 1 1 1 . -9 s s 2 O bfi o O co -\aw 3o 30 0 a ^ ^O o2 0O0i o e ^ ? -3 5 O_ $ 2 'w co G _,,2 <irMt *- So o e i5 "a co p o o3H VJ, 3 --. TC5 ai ai ai io i aai ?_ [ ,; ai oe :3 s ! co ho s iCO ai ^ 73 -OQ XC! T3 3 2"S W i> IOH eMt 3 O a) S ed L< tJ % o a 5 fi - a5 oa co 1 co g --S oa CO M w Jf3i Xe! B2 < .52 -ga> H bo 52 ~a 7id3 'C -- 0 j5 co 351N33 NOIlVWiOdNI H11V3H QNV 13JVS lVN011VdiD30 1VN0I1VNJJ31NI O |A O IJ ENPI 231-1963 CIS 44-1964 Fsh G tz M pz T a lc o sis (T a lc o s e ). Tolk, J .J .C . MT yd sch rift voor so c ia le gen eesk un d e", A ssen, N etherlands, 27 September 1963, Voi. 41, No. 19, pp. 597-600. Illu s. 1 5 b ib l. refs. During the examination of 12 w orkers who for 10 years or m ore had been exposed to talc dust in the rubber p rocessin g industry, 8 ca se s of pulmonary ta lc o sis w ere d isco vered. The X-ray findings are described. This has led the author to assum e that the incidence of ta lco sis is higher than was previously thought. The author d eals with m ea su res for the reduction of talc dust concentrations in the extrusion of rubber. J 5 7 V CO o Aettopathology and clin ica l asp ects of ta lc o sis ( Aspetti etio-p atologici e c h n ic i d elle pneum ocom osi da ta lc o ). Rubino. G ..F ., Maranzana, P . , P ettin ati, L . , and Scansetti, G. " Medicma del la v o ro ", Milan, Italy, June-July 1963, Vol. 54, No. 67, pp. 496-506. Illu s. 10 bibl. r e fs. R esults of a survey carried out on 357 w orkers employed for m ore than 3 y e a r s in the m ining and handling of talc (ta lc m in e r s, talc g rin d ers, and talc sp rea d ers in the rubber industry). From the clin ical point of view , it was observed that the incidence of pneumo co n io sis (v ery low in talc w ork ers) d ecrea sed in proportion to the in crea se in d istan ce from the m in e. O ptical, m icro sco p ic and X -ray diffraction an a ly sis showed that d iffer ent types of industrial talc are contaminated with such m inerals as trem olite, serpentine and quartz which are w ell known fo r their fibrogenic action. In its pure sta te, talc w ill not cause pneumoconiosis. --i- p - v ' z r W-'t O Ci - ^ ce ? w ac ^ Z- C O v* ~nj f~* S X H-] 2 N 0 a ci o ^ a bc a U S P % U O Z -S -. g N 2 C CQ _ r t = CTi TJ a : s-h - c _ w ti c S g S S O G _ 2 LO g < O -C 5 S 3 x > -a c ai ^ To- S TT33 E 2 p^i C O c S bX3 u - O C c O K <T3 O> caI ? s * _T Q W et s o O ^ .G O 5o ~ v' ^ w^ g* s * Sh '-H c og ce ^ P te _b_i 5 rO w <D -n S OQ 3 c a3 hr c o i_ -- ^ -->> -*-> a^i J --ci- Oc c - E HS S S 2 ^ --` . o ja co -3 C 3 c -*-* t s -- ? c > - c 9 - ' > ^ ' rat ^ X 2 et U aO e>t 38IN3J NOUVWSOJNI H13V3H CNV A13JVS N oiiw roe o iv n o iin h in i S ID X Z O" Q. 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C) t~. ; f a ">Cl .n-s' H S0_ M0) 5, et w-- ^ S JOeI Cot Sd to ^ u . a 2o 2g* >sT>sc ,,o J5i So H - ,, O t. , 3S1N33 N0I1VW803NI H11V3H 0N A133VS IVNOIlVdfDIO 1VN0I1VNS31NI O I O IU en fi 15-1964 CIS 1135-1964 Fsh Gtz Mpz Q tz C linical and radiological evolution of pneumoconiosis in the talc extract.no- inrl,,=tr,. L l ^ o )UZIs f S P ^ ^ l0 f t Ca Tde U e Pne u m o c o m o ^ t n e lF i n c iu stri a e s i a t t i T a d e l U ah' N o S e r 1963 V I " f f Ghemi, F. "M edicina d e lla v o ro " , Milan, n a n , l \ o \ e m b e r 1963, Vol. 54, No. 11, pp. 746-749. IUus. 1 bibl. ref. 5 u C 7 function tests oi -X s :emrr ENPI 110-1964 Fsh G tz Mpz Qtz Radiological and clin ical a sp ects pHpneum oconiosis in the m ining of talc ( Aspetti rad io- logici e clinici della pneumocomosi nell'industria estrattiva del talco). Pettinati, L., C oscia, G .C ., F rancia, A ., and Ghemi, F. " M edicm a del la v o ro ", Milan, Italy, 2 -- January 1964, Vol. 55, No. 1, pp. 58-63. U lus. 3 bibl. refs. 5 5 Paper read at the 25th Italian National C ongress of Occupational Health (Taorm ina, Sicily, October 1962). The authors examined periodically 260 mine workers exposed to talc dust. The number of norm al radiographs d ecrea ses progressively with in creas ing lengths of exp osu re. The radiographs of p erso n s exposed for m ore than 30 y ea rs were all outside norm al lim its, and sim ila r to those of m ixed -d u st pneum oconioses. The rad iological featu res w ere often accom panied by b ron ch itis, em physem a and d isp - noea. Electrocardiography revealed p rogressive right heart involvement in more than 50% of the c a s e s (a x is deviation, right v en tricu lar hypertrophy). 52 o AND HEALTH INFORMATION tfcNIKt o , JD t ' g 3 : H ?r H ?3 wo f5 c f I 3 ! ^ - ccrq 3 5 v d : > n 3 %a , ag : G- ijJ-U EJ C CIII 3w 3" 13 o 3 o rt M " "S g S N * o iS c3c;o S o x 4^ 3 3 1 o-o<a; 3" p 9 ^ a3q O O 33 INTERNATIONAL OCCUPATIONAL SAFETY AND HEALTH INFORMATION CENTRE 5T 3O 3 P 33 't 2- 3 c ^c g o 3P: i3 e3 cP ^ O Q< c X B 3 c *3 'S o C w 2 o Tl 3" O (n X , w -p o " s ;t orr S' N -"1 ^ >- w P o Z "O , ~ Kfi X. P O -c N qpg Ic-- o _ C-. er N ' C* a 3- ! oX c 1; L M O - 1063 \-.ir> 2497-1963 la l( pno i^rnoconio siK - A re u o rt n f , , M ^ e .'a m ^ b .T T T U fa Ltl ." , C h ic a g o , I I I ., USA J ul y l % - Vn , refs. ' V 1Jb" - V o L Fsh , * 7 x ' ^o- Gtz Mpz K l c n f e l d . M. fvch.ve.s of Environmental 1, pp. 101- 115. U lu s . U b i h l < w orkers. who w o re exposed fo r an able am ounts of talc adm ixe d w ith tre i a ve rag e of 24 j e a rs to a dust c ontaining a p p re c amount of free s ilic a developed a sym. ro lite and a ntho p hylhte and containing a s m a ll m eal teatures w ere chronic productive Itom atie fo rm ol pneumoconiosis. The m ajot eii- ted Chest expansion, d iffuse ra le s , am cough, dyspnea, d im in is h e d b re a th sounds h m ip la in t and was p ro g re s s iv e . The her I clubbing. D ys mea was the m o st constant comd ila tio n of v a ria b le degree both basal roentgenogram u su a lly disclosed in te rs titia l l o e ly spared. Ooi p u lm o n a le was the Y and m the m i ilur>g f 'c U s w ith the apices re lu < la n is m of death in ,`i. In g e n e ra l the m a jo r c o m p lic a tio n in 4 of the 6 cases and the me- ,nf w e re s im ila r to those o bserved in clm ical, roentgenographic and pathological rlnfJ_ p u lm o n a ry ta lc o s is has not been a s s o c asb ostosts. However, in contrast to the latter ('inojnu uted with an increased incidence of pulm onaiv r : ,, - (NML) ROSPA CIS 106-1960 3087-1960 1 Fsh G tz M pz Talc pneumoconiosis Kipling, M. D ,, and Bech, A. O. Transactions o f the Association oj Industrial Medical Officers, 1 ondon, United Kingdom, October 1960 Vol 10 No. 3, pp. 83-93. Ulus. Bibl. ' '' 2p 2c A review of past experience of 1azards in the use of talc is followed by seven case histones with clinical details and >.-rays, of which four cases occurred in the manu- Z< 3"=! tacture of lead accumulator plates (one with five years' exposure), one was that of 2 ^ worker*" ^ eXtmder' onc an aIurn!nium die-caster and the last an aluminium foundry (A) (/) o USPHS 90-1965 CIS 1261-1965 Fsh Gtz M rz Pop 1=> a*n -- o 2 2 9 Effect of talc dust inhalation on lung function. Kleinfeld, M. , M essite, J. , Shapiro, J. , and Swencicki, R. "A rchives of Environmental Health", Chicago, 111., USA, March 1965, Vol. 10, No. 3, pp. 431-437. Illus. lS b ib l.r e fs . Pulmonary function te sts were perform ed on 43 workers engaged in the m illing of talc The mean duration and weighted average of exposures w ere :9. 0 years and 62. 3 mppcf, resp ectively. The predominant sym ptoms w ere dyspnoea (29) and cough ( 1 2 ) . B asilai crepitations and clubbing w ere noted in 12 and 8, respectively. The mean predicted values for the various pulmonary function param eters m easured were within the 95% con fidence lim its of the control group. However, an appreciable number of talc workers had values which fell outside these lim its. This was paiticularly evident in the vital capacity, total lung capacity, and Dl q q . There w ere 16 who showed pulmonary' infiltration on their chest roentgenogram s as compared to 27 without such evidence. In general the correla tion between pulmonary function impairment and cluneal and roentgenographic findings was poor. (NLM) J 1 Tt JL Pulmonary talcosis, a clinical and environmental study. Messite, J., Reddin, G. and Klcinfeld, M. 'l.A/.A. Archives o f Industrial Hedfth, Chicago, 111., USA, Nenemhi r m , Vol. 20. No. 5, pp 408-413. Illus. Bibl. Describes an industrial hygiene survey o f talc mines and mills in New York State. I ho institution ot wet drilling has reduced the dust exposure in the mines and low eiej the incidence of pulmonary fibrosis among talc miners. The authors indicate that, while, both types of talc can produce pulm onary fibrosis, the fibrous or tremohte variety is the more pathogenic. V h w 3 o 3 TJ n g N ^ o c JT ^ c 9 - -- . . '3 M s - : i ' O g '--1^ '- - ci 3 ^ :r m , ' H 9- " c ^ O ^ Br O ^ " x > 7 3- C IS INTERNATIONAL OCCUPATIONAL SAFETY AND HEALTH INFORMATION CENTRE 3 x a g a 3 5 g c >" 6 C 3 2. Ir o 1 0_ y *-i ^ B en 4 a 'a Z ^3 r~f 2 O ' <? Oo .y 3 a f > o .b o - 3. 3 WO --" ` '3 "! ^ g. H ^ ^ fl ^ ~? OZ " 3 5 a 3 ?,, 2 , z T3 o a N r, o OO 3 O1 ^ c c * (/) * This card annuls and ieplaces the card already issued w ith the same CIS num ber, which bore the incorrect co d e Fsh M pz : si. SUVA 2-1969 CIS 1083-1969 Fsh Gtz Mpz S ilicatoses (a s b e s to s is , ta lc o s is ) (Silikatosen ( A sbestose, T alkose)). (Also publish* in F r e n c h .) Schlegel, II. " B er u fsk ra n k h eiten - M aladies p ro f e s si o n n e ll e s " , Schwei zerisc h e U nfallversicherungsanstalt, Lucerne, Switzerland, N ovem ber 1968, M e r k b l a t t Mr. 1. 7 pp. I ll u s . 6 b i b l . r e f s . o=>. oe F i r s t of a s e r ie s of inform ation sh eets published by the Swiss National Accident In o 5 surance Institute and designed for the Swiss medical corps. Subjects dealt with mchido a s b e s t o s ;ind ta lc h a z a r d s and w o rk in g e n v iro n m e n ts w h e r e th ey m a y be c n co u n ie ie d . uptake and pathogenic effects of asb esto s and talc p a rtic le s; diagnosis; prophylaxis and technical protection; insurance p ra c tic es; incidence oi a sb esto sis and talcosis m Switzerland. m o USPIIS 73-1967 ('IS 1602-1967 Fsh G tz Mpz Commercial talc and talcosis Weiss B. . and Boettncr F.A m e nta l l U a l t h " , C h ic ag o 111 USA i'cbi u a r y 1967 . Vol. 11 Illus. 13 b i b l . r e f s 'A r e l m os of F r u onN o. 2 pp .!<)- '(i- T h e a u th o rs s ta t e th a t it has still not b e en iullv d e te rm in e d w h e th e r ta lc o s is s c a u s e bv m i n e r a l t a lc o r b y o t h e r m i n e r a l s th a t e x i s t in c o m m o n ml ta le Oiu iliflu.it t v in ' ip stu dy of th is s u b je c t is the la<k oi m i n e r a l o g i c a l u n i t o r n u t ' b e tw ee n d i l i c r e n t t tl e o i p o s its , and m o r d e r to clarify m ineralogy irom the occupational health standpoint ti e authors have studied the principal talc deposits worked m the United M ates. 1;k posits fall into 2 groups: (a ) deposits formed from carbonate rocks usually eon p r i m a r i l y of t a l c , t r e m o h t e and a n th o p h v lh te , ( h ) l e n t i c u ' a r o r e s oi s e r p e n t i n e c o n ta in in g ta l e , m a g n e s i t e and c h l o r i t e . The f o i m e r t \ p e was found to lie a gre.. t e r ill d u s t n a l h a z a r d . It is thought th a t th e l a t t e r t\p c m a y In' innoc uous and ii th is ta c t c cad t/) bceo mc omnefri rcmi aeldt,a liet wdeopuelnddiinndgicoantethteh eo rniegei nd oi oi rthaet hmaast et r i2a dl ifft r e n t th r e s h o l d h i n t \ lin e - o o 1 c. J KNri 14-UT1 ris u : u - \'M\ \ Fsh Gtz Mpz Qmj O O U) I o Dust exposure in talc grinding ami corresp onding hazard ( Ksposizionc p risehio nello opei'll7ioni di maomatur t del tulco). i ron.Mno, 1,, , Oosoia, G .i', f and Oapellaro, F, 11Modtema del lavoro", Milan, Italy. Nowunbor 1963, Yol. 54, No. 11. pp. 744 745, Ulus. 2 bsbl, reis. Taper road at tho 25th Italian National ('engross of Occupational Health (Taorm ina, SumU. October 1962), l'lio authors studied workers engaged \n the milling of talc, none ot whom had prexioush boon engaged on dusty work. Tito moan average age of the wholo group was 47.il t o n s with in average duration oi exposure of Ul.fi years. The w o ik e is wore dixuiod into 3 groups (up to 10 w a r s ' exposure, 11-20 years' exposure, m ou' than 20 \o a i s ' exposure ). Nearly 50'\ prosonted no ovidonoo of pneumoconiosis. 1ho iollowmg symptoms woio touml in tho 11 -20 years group : increased linear markings (5 o a se s); modulation t'2 ea st's), ealcificat ion or p leu ro-losion s (4 o a se s); emphysema ( 3 oases ), enlarged helium shadow s (2 e a se s ). The authors ooncludo that the longer the duration id exposure, the more tiequent wore the number ot o ases of pneumoconiosis whit'li oould ix' diagnosed i uhologieaUy. I'SPHS vs-iooa ns 1249-1905 Fsh Gtz Mpz Pop. wO ^ < =c -- o moci i n; Kl mnl i ' hl . M. , M o s s i l o , ,1., S h a p ir o ,1. Swi-ncirki, H. , mid S a r k ' U . ,1. ".Journal ol O ccupa ti ona l M e d ic in e " , O hic aa o 111' ' " ' V'SA, .limitary Uhls. Vol. 7, No. 1, p p . J k - 17. Illu.s. 11 Mid. r o t s . ' " I m m o n a rv function tenta v i t p e rlo rm e d i,, k; wm-kci.s who w ore engaged in llio m i l l . n s ot ta lc l o r m o r e than 10 y e a r s and who had c l m i c a l and ro r i i l KonoRn i Plii<- Imdin TM c o n s i s t e n t with ta lc p n e u m o c o n io s is . In 1 1 ol (he 1(1 w o r k e r s , th e p n e u m o c o n io s is w a s ' s im p to m a lie Dyspnoea was the predominant s \ n , Ptom. t'oupli was p re s e n t but not con s i s t e n t . t h e m e a n d u r a tio n ol e s p o s u r e w a s 70 1 y e a r s , with a ra nj;e ol 311-2, and tho moan wciRhU'd a v e r a p e o x p o s m e w a s (18.0 mppel ( m i l l i o n s o f p a r t i e l e s p e r ru in e foot ol a " ' - , 1,10 laUl' ' `'xclH',ih the p r e s e n t t h i e s h o l d ol 70 mppel a s re e o i n m e n d e d by the A m e r iean ( onlerenee ot lhn ern m en t.il Industrial llvpienisls. The ehanges mdieated that there was an impairment m yontilatmy lunetion and dillusion eapaeity for eurbon monoxyde ( 1m<'0 ) m a s i g m i i e a n l m im b i'r ot im h\ idu.iis ' ' ( NI.M) ILO 146-1966 CIS 843-1966 Fsh Gtz Mpz Msb : mn Determination ol dust particle siz e in the lungs and lymph nodes of tale industry workers < by means of the electron and phase contrast m icroscope ( Elektronen- und hchtm ikro- skopischc Korngrofienbestimmungen an Lungen- und Lymphknotonstauben von Talkum O o arbeitern). Einbrodt, H . J . , M etze, H: , and K losterkotter, W. " Arehiv fr Hygiene und B ak teriologie", Munich, Germany (F ed Re p . ) , 1965, Vol. 149, No. 5/<>, 8 pp. ( special issu e). Illus. 12b ib l.rcfs. <=> Dust isolated by means of formam ide from 12 lungs, including 9 with lymph nodes, was examined to determ ine the particle s iz e distribution. In all c a s e s, the lungb w ere those oi workers in the talc industry and m ines m Styria (A u stria ). The dust was counted I by electron and phase contrast m icroscopy, and the resu lt expressed in summation graphs. It was lound that particles in the 0. 05 n to 0. 2 \i siz e range w ere especially prone to be taken up in the lymph This selectivity is ascribed to the silic a content of the dust, since no preferential transport via the lymph is observable in pure ta lco sis. It may be ( / ) assumed that the hazardous p articles are to bo found in this particle siz e range. o J