Document 2J6NvX1bGpRaK8wGnZ8jXMKJ7

Younger Laboratories &ioclt6*ntiti . . . PhaAMoadacjMU . . . iAnalqUi 3620 Telegraph Hoao St. Louis 29, Missouri PHONE! TILDEN 6-2.110 Qe/diiiocde Of AmbjAiA. rurjicr - '- Tckc ologicd InTestigciian Of I Aroclor 2!cnscrrto Sample limber h6 Kmscato Project limber T-62-44i . July 3rd, 1962 C-v-y-Ai^ std: i coir uctu fcr Konsants Chemical Caspany, St* Louis* Missouri 3DEpSlT10N^ exhibit zips -TKrrr'L x cczruic - ' :) Ore.I L e0 ( eta) The diluted compound uro to rpr' pue^lfwley strain r.lbiro rats, .'ftar the appro r:.t3 were fed four levels . calculation o: of 2. J. uq 2 e yav e'etornired, groups of male rnd ferule rererts of 0.1 fraction: 1 lo; intorr la ct tlcity range thereby supplying ::ct* for according to a modification of the method Observations w acode symptoms sal the viscera of the animals that Guccunbed were n icroscqplcally. The data* together with the dilution at which the compound was fed, are shewn in Trhla I. B) Skin bsorptioa Ilf (Rabbits) The diluted compound va.s applied in increasing dcaco nt increments of 0.2 fractional log iutcrvrla to the closely clipped, intact in of hen/ 2c - lend white female Titbits* The trooted areas wore covered with piratic strips end tin eninrls placed in voix'en stocks for periods up to tuonty-faur hours* after which time they wars GB.:i(.T3ed to individual cages. Observations were made for tcaic symptoms ani tn vis care cf the a.niaa Is that succumbed were cX'r.lr.cJ m crosconically. The c't*, together with the dilution at which tic ccnpounJ sra applied, are ahem in Table II. SCM 002622 This confidential report u not to be ueed in any form of advertising without written permiuion 0024a HARTOLDMON0021820 To I Ibnsanto Chcnicr.l C ^>cry . 't. Louis, lusscurf, lounger Laboratories Certificate of nslyais - Page 2 (l/j/C2) - r<2-hk 'J?n EEl.T.-L ? OGT'uE - (Continued) C) Skin IrriicticH (Rabbits) Tbo finely ground powder and a 5o.c solution in com oil were s^Uad to the clipped, intact skin of ; lbino rabbits an: renerrod after t'.:cntyrour hours ' with soap rod warn voter* The application was covered with pi stlc stride to retard eraporKtion cad avoid cantrn.ln.at, 1, * aberrations were nadf over s period of arrcrcl days for irritation. Tbo data, scored according to the nethod of 'reiae, '-'cod--it! and Cr. Ivory (JcxLm.il of Phaa* and llrpmrtieS| 7glns 82, eceabar, 19Wt) cxb shown in Table in* T.) E;e Irritcticn (Rabbits) Twenty (20*0) KilUgrrus of finely ground sample vere placed in the ccnjunctinl sac of the right eye of each of three' albino rabbits and obsemticas nad over a period of cororcl days for inflcxcntiOT, The eyas were rirsed with va.m isotonic saline solution after twenty-four hours. T.ie data, scored according to the method of `raise, ei al# are shown in T-ble 17. - S17X RT ; roelor h!i6S> A) Orel L gg (Rats) The Orel L go for nalo end fenale rets was placed at 16,000 nilliprcrs par kilogram with lower and taper Units of 13,760 to 18,560 nilliarms porkilocrra. The compound was classod as pre cticoily ncn-toxLc by oral L-gestion in nrlo and ferule rsta. , D) Skin bscrptico Ilf ( abbits) The Ilinirun Lethal oce by skin absorption in fena-lo r-bbits wts founi to be greater than 2000 nilligrarifl per kilogram nnc! leS3 thru 3160 nilligrors per kilogr-a. The compound was classed as slightly tcccic by akin absorption Li ferrla rabbits. C) Skin Irritation (Rabbits) The ccaspcund was classed as a Moderate skin irritant. The ever: go m'Xinm score was 3*6 cut of a possible 8 in twonty-four hours. V) Ea* Irritation (Rabbits) The compound was classed as a Mild eye irritant. Ths cTBrcge maxima score was 19.6 out of 0 possible 110 in four hours. YOQKET: L'BCR TORES SCM 002623 HARTOLDMON0021821 Tot Jbna-'nto Cxrvic -1 Company . Si louie, Kiasouri Younger Laboratories Certifiesto of /n.-lysis - Page 3 (7/3/62) - 1-62-14; T BLE I TIE Cfl/L LT ao 07 ' / roclor 14165' ; Cfl PATS Sample Fed As A $0QX Solution to Com Oil 'ninal Ko. - Sex 'eight -Ga 0 7sa Hf. /Kg 1- Formla 2-- Fer.sla 3- Feme la k- 16 la 5- KalS 6- Kale 7- Female 8- Female p- Female 10- Kale 11- Kale 12- Kale 13- Fc-r.r to lU- Far. c la 15- Female 16- Kale 17- Kale lo- Mala ' 1?- Fiyr.iil* 20- Kale 200 10,000 190 10,000 215 10,0.00 230 10,000 225 10,000 2h0 12,600 210 12,600 225 12,600 215 12,600 2h0 12,600 250 15,300 235 15,300 220 15,300 215 15,600 210 15,300 25| 20,000 250 20,000 230 20,000 215 20,000 2h0 20,000 Fat# Survived Survived .'urrived Survived Survived Survived Survived Survived Survived I lad Survived :isd Survived ' led Survived led Survived Tied Died riad risccssics - The Oral L"80 for nr to end female r ts was placed at 16,000 jailHcrrr.s per kilogram ulth lower and upper limit a of 13 *760 to 10,560 milligrcras per kilocrrr. Tba oameimd was olsasod r.a practically non-toxic by orsi Incest ion In arto end female rata . Surrivnl tins we a two to air clcyg with cost deaths occurring in three to fair c.-ys. Taric aynptana included mrem diarrhea, leas of appetite, and increasing weakness At .--ctopsy thoro t-rs infianrr.tian of the gastric r.ucosa, liver discolor; tion, -nc renal hyperunic. mrcroocopic-lly. SC M 002b2<t 002.10 HARTOLDMON0021822 Tot Kcnacrrto Ohmic-1 Ccripnny ft. Louis, I-iissourl Tocmcer laboratories Certificr.te of Analysis - prc8 I* (7/3/62) - r-CZ-kh TABLE rr THE K'NIKOH LETLL : 03F 0? Lroclor MS' m sm .BsauncH m rabbib Sample Applied As 0.02 Solution In Com OH /ni-al No, - Sex './eight Kg. ' 0811 Mfe /Kg. "eight Qmngt 5 l ays Liter ft. 1 - Female 2 - Female 3 - Female I; - Fenala $ - Female 6- 2.3 2.6 2.S 2.7 2.1 2.6 79h 1260 ' 2000 2000 3160 5010 0.2 + 0.1 - 0.2 - 0.1 - 0.3 - 0.3 Fate Survived Durvivsd Surrired Survivod Tied - 21 Cays Tied - 9 Cays riscoocicjr - The Kinir.ua LetiirJ. oao by Skin Absorption L-. ferric rrbbits mi-.3 fount to bo gra-vtcr than 2030 BnH[r,xa per kilogras Mad less than 3160 nilligrcna par kilogn.n Ths cor^comd was cl.'.sscd re slightly toxic by skin absorption in fcnals robbits. Survival tira was nine to twonty-cna days. Toxic aynptms included lethargy and reduced appetite after ocvcrel days, Those succtsabinc developed traaors and an mamic-lika appecr'nca several ir.ys before decth, t autopsy there was liver diacolorat cn and pulncn-17 hyperemia microscopically. ..... ........... ... in tuts report is to be used in development of the product and may be given to responsible sales contacts, but it is not to be used by them in advertising copy. The source of this material is not to be divulged until it appears in formal publications. No exceptions to the established rule may be made without the approval of the Medical Departmeat in St. Louis. Customers' inquiries regarding matters of toxicity are to be referred as before to the Medical Depart ment in St. Louis for reply. -- Monsanto Chemical Company SCM 002o 25 0025 1 HARTOLDMONOQ21823 To I Monsanto -Ixaaicrl Canpary .t, Louis| tisarari, lounger Laboratories Certificate of Anal sis - Page $ (7/3/62) - T-62-^4 i? ^ 2 ^ J* SEN EmiT. TICN IN It 33ITS AFTST. /rPLICL'TICH CF rcclor 446$' Srjipla /'ppliod Finely Ground Powder Srapl* Applied A* A $0,0# Solution In Cora Oil Anir.al Hunber Jtaerie.'l ~rr lurtica t The End Gf 1 Hour It Hours 24 Hours 46 Hours 72 Hours l: 0 Hours l68 Ifoura FDHU grcon". PCWTER 1 02 k3 2 1 2 01 3 3 3 1 0 3 02 320 /.verrge 0.0 1*6 3*6 3.6 3.0 1,6 0,3 i: C' 33X11 - The ecnpcund was classed as a noderrte skin Irritant. 72.TLF CP CUT PCSf Eli Ho skin charge was noted after orb hour. Slight to well define! erythcrw with no edcr.a evolopsd within four hours for rn tverr go score of 1.6 out of n possible 8.' Overnight there ves alight e:cnr, inc wains the nrer.-ge score to 3,6. Although tho -pplic-ticn vra ten eyed, no suvGt;ntirl chrnge v.-s noted until the fifth day when the ever.'go scow dropped to 1.6. Econo had disappeared but slight -redness vna still present $0* SGLDTICN IN CCRN OUl A $0,0,2 solirtion In com oil produced elr.c3t identic'1 d.-ta to that ahem bovet placing it in the *noder to !dn inlt-nt* e-tegoiy. . SCM OOZoZo 00252 HARTOLDMON0021824 To I Kcnar.nto Chcr.ic 1 Cccipaay St Louis, Msscuri Touncor L; tor. tories Certificate of /nalysis - Page 6 (7/j/c2) - y-C2-hk T /. S L E If EE EP-IT/TICN IN PJ B'.'ITS /FTZR APPLICATION OS '/roclor Uh6$i SazpIJS (20*0 MilHgrcna) Applied As Finely Ground Powdr Aninnl number Runoriccl Pyalueticn t The rhd Of 1 Ecur U Hours 2li Hours U8 Hours 72 Hours 120 Hoars 160 Hoars 1 1$ 18 13 9h 2 0 2 12 18 18 U 8 h 0 3 15 21 18 Ik 8 h 0 Averse li**0 19.6 16.3 11.6 6.6 2.6 0.0 ' ISCISSICN Bio ccnpound was classed as a nild eye irritant* ekj . isccnfoit was r.ild imxd lately following applic. tier. after one hour there was nodorata discharge, nUd redness of tiro conjunctivas, mild edena, ;nd slight Iris concostim for an averago score of lU.O cut of a possible 110* Dullness increased slightly in four hours end little change was noted overnight. After ir igaticn the infl'.xanatico gr..du* ly reduced so that by tho fifth da iris road cornea wore noracl. Slight redness of the palpebral conjunctivas remined for an aver: c score of 2*6, idrt ClU2o27 no2.^a HARTOLDMON0021825