Document 2J3GB4Eg67oVVnOzJKMGV6L4g

THE NEW YORK ACADEMY OF SCIENCES East Sixty-third Street New Yotfc, N.Y. 10021 MAY 10, 11, 1974 WORKING GROUP TOXICITY OF VINYL CHLORIDE POLYVINYL CHLORIDE E. Cuyler Hammond, Sc.D., President Kenneth Wade Thompson, M.D., Acting Associate Executive Director Herbert J. Kayden, M.D., Chairman, Conference Committee Co-Sponsors: - American Cancer Society National Institute of Environmental Health Sciences National Institute for Occupational Safety and Health Society for Occupational and Environmental Health All sessions at THE DELMONICO HOTEL rk Avenue 59th Street New Yotfc. N.Y 10022 FRIDAY, MAY tO, 1974 ---------------------------------------- URL 18504 CONFERENCE CHAIRMEN: Irving J. Selikoff, M.D. Mount Sinai School of Medicine of the City University of New York and E. Cuyler Hammond, Sc.D. American Cancer Society New York City, N.Y. 8:00 A.M. REGISTRATION 8:45 A.M. GREETINGS FROM THE ACADEMY E. C. Hammond, Sc.D., President INTRODUCTORY REMARKS 1. J. Selikoff, M.D., Mount Sinai School of Medicine of the City University of New Yoiic 9:00 A.M. MORNING SESSION SESSION CHAIRMAN M. M. Key, M.D. National Institute for Occupational Safety and Health Rockville, Md. NON-MALIGNANT DISEASE CHAIRMEN E. Mastromatteo, M.D. International Labour Office Geneva. Switzerland and M. N. Johnson, M.D. B. F. Goodrich Co. Akron, Ohio La CLINICAL MANIFESTATIONS AND COURSE OF VINYL CHLORIDE DISEASE G. Veltman, M.D., C. E. Lange, M.D., S. Juhe, M.D., G. Stein, M.D. and U. Bachner, M.D,, University of Bonn, Bonn, Germany b, FURTHER RESULTS IN POLYVINYL CHLORIDE PRODUCTION WORKERS C. E. Lange, M.D., S. Juhe, M.D., G. Stein, M.D. and G. Veltman, M.D., University of Bonn, Bonn, Germany 2. DISEASE AMONG VINYL CHLORIR^,-,,, POLYVINYL CHLORIDE WORKERS IN ROMANIA -- OBSERVATIONS 1963-1973 I-Syciu, MD. L. Prodran, M.D.. E. Ilea, M.D., A. Paduraru, M.D., C Valaszkai, M.D. and L. Pascu, M.D,, Occupational Diseases Clinic, University of Cluj, Romania FRIDAY, MAY 10, 19/4 3. LIVER DAMAGE AMONG POLYVINYL CHLORIDE PRODUCTION WORKERS J. I.. Creech, M.D and L. Makk, M.D,, University of Louisville. (.ouisville, Ky. 4. ACROOSTEOLYSIS IN VINYL CHLORIDE PLANTS IN JAPAN H. Sakubc, M.D., National Institute of Industrial Health, Kawasaki, Japan 5. PREVALENCE OF DISEASE AMONG VINYL CHLORIDE AND POLYVINYL CHLORIDE WORKERS g^JLilis, M.D., S. Daum, M D., H. A. Anderson, M.D., S. A. Fisehbein, M.D. and I. J. Selikoff, M.D., Mount Sinai School of Medicine of the City University of New York Discussion opened by: P. Berk, M. D., National Institute of Arthritis, Metabolic and Digestive Diseases, Bethesda, Maryland and A. Miller, M D.. Mount Sinai School of Medicine of the City University of New York 6. UNUSUAL SPLENOMEGALIC LIVER DISEASE AS EVIDENCED BY PERITONEOSCOPY AND GUIDED LIVER BIOPSY AMONG POLYVINYL CHLORIDE PRODUCTION WORKERS H.J. Marstcller, M.D..W.K. Lelhach.M.D , R. Muller, M.D. and P. Gcdigk, M. D., University of Bonn, Bonn, Germany. 7. ALTERATIONS OF LIVER ANDSPLEEN AMONG WORKERS EXPOSED TO VINYL CHLORIDE H. Popper, M.D., Fogarty Center, National Institutes of Health, Bethesda, Maryland and Mount Sinai School of Medicine of tire City University of New York, and L. B. Thomas, M.D., National Cancer Institute, Bethesda, Md. Discussion opened by: P. Gedigk, M.D. University of Bonn Bonn, Germany EXPERIMENTAL OBSERVATIONS CHAIRMAN E. J. Fairchild, II, Ph.D. National Institute for Occupational Safety and Health Rockville, Md. 8. BIOCHEMICAL APPROACHES TO EVALUATION OFBIOLOGICAL EFFECTS OF VINYL CHLORIDE P. Gchring, Ph.D., Dow Chemical Company, Midland, Michigan FRIDAY. MAY TP. 197.1 --- Uql Discussion opened by: Ci Ostcr. Ph D.. Mount Sinai School of Medicine of the City University of New York and R. J. Jaeger. Ph D., Harvard School of Public Health, Boston, Mass. LUNCHEON 2:00 PM AFTERNOON SESSION SESSION CHAIRMAN R. S. F. Schilling, M.D. London School of Hygiene and Tropical Medicine London. England NEOPLASTIC EFFECTS CHAIRMAN J. W Ltoyd, Sc.D. National Institute for Occupational Safety and Health Rockville, Md. 9. CHARACTERISTICS OF CASES OF ANGIOSARCOMA OF THE LIVER IN U S. VINYL CHLORIDE POLYVINYL CHLORIDE WORKERS C. W, Heath. Jr.. M.D. and H. Falk, M.D., Bureau ol Epidemiology, Center for Disease Control. Atlanta. Georgia ^ C\.` " ^ 10. MORTALITY STUDY Of'POLYVINYL CHLORIDE WORKERS I. R. Tabershaw, M.D., and W. Gaffey, Ph.D.. Tabershaw-Cooper Associates, Inc . Berkeley, California. 11. INDUSTRY WIDE IN VESTIGATION OF DISEASE MANIFESTATIONS AMONG WORKERS EMPLOYED IN VINYL CHLORIDE -- POLYVINYL CHLORIDE PRODUCTION J. K. Wagoner. S.D. Hyg., J. Mallov, M.D. and W Stringer, M.D., National Institute for Occupational Safety and Health. Cincinnati. Ohio. 12. MORTALITY EXPERIENCE OF A COHORT OF VINYL CHLORIDE - POLYVINYL CHLORIDE WORKERS. 1946-197.1 W J. Nuholsnn, Ph.D.. E.C. Hammond, Sc.D. and I. J. Selikoff, M.D.. Mount Sinai School of Medicine of the City University of New Yotk and the American Cancer Society. New York Cily, New York. Discussion opened by: T. F. Mancuso, M.D., University of Pittsburgh School of Public Health. Muriel L. Newhouse, M.D., London School of Hygiene and Tropica) Medicine, London, England and FRIDAY, MAY 10. 1974 B Holmberg. Ph.D., National Board of Occupational Safely and Health. Stockholm, Sweden. 13. PATHOLOGY OF ANGIOSARCOMA OF THE LIVER AMONG VINYL CHLORIDEPOLYVINYL CHLORIDE WORKERS L. B. Thomas, M.D. and H. Popper, M.D., National Institutes of Health, Bethesda. Md. DfWfmiwi opened by: H. L. Stewart, M.D., National Cancer Institute. Bethesda, Md. and O. Auerbach, M.D., Veterans Administration Hospital, East Orange, N.J. EXPERIMENTAL OBSERVATIONS CHAIRMAN U. Saffiotti, M.D. National Cancer Institute Bethesda, Md. M. HEMATOGENOUS DISSEMINATION OF INGESTED PVC MICROPARTICLES G. Volkheimer, M.D., Berlin, Germany 15. CARCINOGENICITY BIO-ASSAYS OF VINYL CHLORIDE: CURRENT RESULTS C. Maltoni, M.D. and G. Lefemine, M.D., Institute of Oncology and Tumor Center, Bologna, Italy 16. EXPERIMENTAL STUDIES WITH VINYL CHLORIDE M.L. Keplinger, Ph D., J.W. Goode, Ph.D., D.E. Gordon. D.V.M., Ph.D.. and J.C. Calandra, M.D., Ph.D., Industrial Bio-test. Laboratories, Inc., Northbrook, III. Discussion opened by: Eula Bingham, Ph.D. University of Cincinnati, Cincinnati, Ohio and B.L, Van Duuren, Ph.D. New York University New York City, N.Y. 7:30 P.M. SUBSCRIPTION DINNER OELMONICO HOTEL SATURDAY, MAY 11, 1974 9:00 A M. MORNING SESSION SESSION CHAIRMAN E. Dixon, M.D. Celanese Coip. New York City, N.Y. SATURDAY. MAY 11. 1074 CONTROL OF EXPOSURE CHAIRMAN C. Levinson International Federation of Chemical and General Workers' Unions Geneva, Switzerland 17. EXPERIENCE IN INDUSTRIAL EXPOSURE CONTROL V. K. Rowe, Ph.D., Dow Chemical Company, Midland, Michigan 18. THE ENVIRONMENTAL THREAT FROM VINYL CHLORIDE BEYOND THE WORK PLACE G. Schweitzer, Ph.D., Environmental Protection Agency, Washington, D.C. Discussion opened by: M. Com, Ph.D., University of Pittsburgh School of Public Health, Pittsburgh, Pa. and V. A. Newill, M.D., Environmental Protec tion Agency, Washington, D.C. PROBLEMS AND PERSPECTIVES CHAIRMAN N. J. Roberts, M.D, Exxon Corporation New York City, N.Y. 19. CLINICAL MANAGEMENT OF WORKERS EX POSED TO VINYL CHLORIDE AND POLYVINYL CHLORIDE C. A. Johnson, M.D., Goodyear Tire and Rubber Company, Akron, Ohio 20. SURVEILLANCE OF WORKERS WITH HISTORY OF EXPOSURE TO VINYL CHLORIDE L. Beliczky, A. Mazzoechi and G. Perkel, Vinyl Chloride Health Committee, Industrial Union De partment, AFL-CIO, Washington. D.C. 21. EPIDEMIOLOGICAL APPROACHES TO THE EVALUATION OF EXTENT OF NEO PLASTIC RISK OF VINYL CHLORIDE--POLYVINYL CHLORIDE E. C. Hammond, Sc.D., American Cancer Soci ety, New York City, N.Y. 22. MOUSE TO MAN -- EXTRAPOLATION OF LABORATORY RESULTS TO HUMAN DISEASE M. A. Schneiderman, Ph.D., National Cancer Institute, Bethesda, Md. Discussion opened by: R. Doll, M.D., Oxford University, Oxford, England