Document 2BMYRVLd6kxQVez9rRm8Y1Mb
CC: H. V. Bradley D. G. Wika
w. A. Bower
H. T. Begg Y. L. Power, M.D. J. A. Schmid T. L. Schrenk J. F. Thanas R. J. Zipfel
June 14, 1984
PERSONAL & CONFIDENTIAL
TO: T. M. KEMP
FROM: J. G. LOSCHIAVO ^ 1.(
UPDATE ON THE C-8 BLOOD SAMPLING PROGRAM
An overall drop continues to be observed in TEFLON Fine Pcwder/Dispersion and FEP Operators. In Table 1, it can be noted from the most recent blood sanple results (right-hand columns) that 10 out of 14 Fine Pcwder/Dispersion Operators experienced a drop in blood C-8 levels. The 4 remaining Operators experienced increases. However, 3 of those 4 Operators experienced relatively small increases (<10%) since their last sanple was taken.
In Table 2, it can be noted frcxn the most recent blood sanple results (right-hand columns) that 8 out of 10 FEP Operators experienced a drop in blood C-8 levels. An additional Operator experienced no change. The one remaining Operator experienced an increase.
Data on individuals who left TEFLON (see Table 3) indicate that the average biological half-life of C-8 in the blood (i.e., the time it takes to reduce blood C-8 level by 50%) is approximately 2.4 years and can vary significantly by individual.
Discussion
Tables 1 and 2 contain blood C-8 data for TEFLON Fine Powder/Dispersion and FEP Operators. Blood C-8 data were obtained from the FLAIR (Fluoropolymers Laboratory Analysis Information Retrieval) program. All blood samples were analyzed ty the C-8 specific method. Only data on Operators who have worked in TEFLON FEP or Fine Powder/Dispersion at least 730 days as of the first of the 3 listed sanple dates are included since new Operators will experience increasing blood C-8 levels until an equilibrium level is reached.
Fine Powder/Dispersion Operators experienced an average 24% drop in blood C-8 levels over the past 2 to 3 years. FEP Operators experienced an average 12% drcp in blood C-8 levels over the past 2 to 3 years.
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T. M. KEMP
- 2-
JUNE 14, 1984
Although many of the Fine Pcwder/Dispersion Operators are experiencing blood C-8 decreases, there are 4 Operators whose blood C-8 levels have increased. However, the increases experienced by 3 of those 4 Operators were relatively small, that is, less than a 10% increase since their last sample result. The increases experienced by the remaining Operator is believed significant, and follow-up with this Operator will be done. This particular Operator works a significant amount of overtime which may be contributing to the higher-thanexpected levels. Follow-up with the one FEP Operator experiencing a blood C-8 increase will also be done.
Blood C-8 data were obtained on 11 individuals who left TEFLON* due to transfer, resignation or retirement (see Table 3). Data on these individuals indicate that, on the average, it takes about 2.4 years to reduce blood C-8 levels by 50%.
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table 1 TEFLON* FINE PCKDER/DISPERSION OPERATORS
C-8 BLOCO SAMPLE RESULTS
000272
Date of First Sample
C-8 in Blood (ppm)
Days in TEFLON* at Sample Date
Date of Second Sanple
C-8 in Blood (ppm)
Days in TEFLON* at Sample Date
Date of Third Sample
C-8 in Blood (ppm)
Days in TEFLON* at Sample Date
1/14/82 2/18/82 10/8/81 8/7/81 10/1/81 2/11/82 8/12/81 4/2/82 1/7/82 4/6/81 3/11/82 8/19/81 3/26/82 9/15/81 7/16/81 7/16/81 3/3/82 2/9/82 9/8/82 10/9/81
26.0 24.0* 11.0
9.4 8.2 7.0 6.9 5.6 4.4 4.3 3.9 3.5* 2.9* 2.6 2.5 2.5* 1.6 1.5 1.4* 1.3*
9,358 2,332 9,260 2,379 5,813 1,989 1,743 8,311 5,765
857 800 871 8,242 9,176 5,652 1,705 5,880 770 829 1,803
1/12/83 2/17/83 11/3/82 8/6/82 9/29/82 2/10/83 7/15/82 3/2/83 1/7/83 5/12/82 3/10/83 8/17/82 3/18/83 9/14/82 6/17/82 6/30/82 3/22/83 2/10/83 10/4/83 10/6/82
20.0 25.0*
8.2 7.9 6.5 7.7 5.9 4.2 4.9 5.6 3.6 2.1* 2.8* 2.3 1.8 2.5* 1.5 1.2 1.3* 1.1*
9,721 2,696 9,651 2,743 6,176 2,353 2,080 8,645 6,130 1,258 1,164 1,234 8,599 9,540 5,988 2,054 6,264 1,136 1,220 2,165
1/10/84
18.0
10,084
No Further Data
11/4/83
5.9
10,017
8/5/83
6.0
3,107
9/29/83
5.4
6,541
2/9/84
7.6
2,717
7/12/83
6.0
2,442
2/28/84
4.5
9,008
1/4/84
4.5
6,492
1/18/84
6.5
1,509
3/7/84
3.2
1,526
No Further Data
No Further Data
9/1/83
0.96
9,892
6/15/83
1.6
6,351
No Further Data
6/17/83
0.95
6,351
2/9/84
1.3
1,500
No Further Data
No Further Data
x = 6.78 ppm
X = 5.81 ppm
x = 5.17 ppm
WM Oo00
g * These values are not included in the column average in order to directly compare the column averages.
JGL:mah 6/14/84 0679m
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TABLE 2 TEFLON FEP OPERATORS 0-8 BLOOD SAMPLE RESULTS
Date of First Sample
C-8 in Blood (ppm)
Days in TEFLON at Sample Date
9/25/81 10/14/81 8/5/81 2/2/82 4/15/82 11/9/81 12/16/81 4/1/81 4/21/81 8/13/81 12/4/81 10/15/81 3/17/82 8/26/81
7.5* 4.5* 4.2 3.1 2.1* 1.8 1.8 1.3 1.25 1.20 0.82* 0.75 0.52 0.51
8,131 7,257 9,456 9,438 8,917 9,139 1,977 5,449
732 8,109 1,145 1,807 5,417
891
x = 1.64 ppm
Date of Second Sample
9/23/82 8/18/83 7/29/82 2/21/83 4/14/83 12/13/82 1/12/83 3/31/82 10/9/81 7/12/82 12/1/83 10/14/82 3/17/83 7/29/82
C-8 in Blood (ppm)
Days in TEFLON at Sample Date
6.3* 1.3* 4.2 2.8 1.5* 1.6 1.6 0.95 1.2 1.0 0.75* 0.72 0.44 0.48
8,494 7,930 9,814 9,822 9,281 9,538 2,369 5,813
903 8,442 1,872 2,171 5,782 1,228
1.50 ppm
Dare of Third Sample
0 8 in Blood (ppm)
Days in TEFLON at Sanple Date
No Further Data
No Further Data
6/30/83
4.2
10,150
3/6/84 2.6 10,200
No Further Data
11/25/83
1.3
9,881
1/12/84
2.4
2,734
4/26/83
0.79
6,204
12/1/83
1.1
1,686
6/15/83
0.94
8,780
No Further Data
10/12/83
0.46
2,534
3/15/84
0.35
6,145
8/23/83
0.38
1,618
x = 1.45 ppm
EID080546
* These values are not included in the column average in order to directly conpare the column averages.
JGL:mah 6/14/84 0680m
9Wioodrv
TABLE 3 EMPLOYEES WHO LEFT "TEFLON*" JOBS
! in Blood When :t TEFLON* (ppm)
21.0* 19.0
3.8 2.1 1.3 0.64 0.57 0.22 0.14 0.11 0.11 x = 4.45 ppm
C-8 in Blood at A Later Date (ppm)
8.4 16.0
2.2 1.7 0.49 0.47 0.14 0.15 0.08 0.078 0.053 x = 2.71 ppm
Days Elapsed Between Samples
1,044 128 780 785 859 563 730 315 759 780 807
x = 686 days
Reason for Leaving TEFLON*
Retired from Company Retired from Company Retired from Company Retired from Company Trans, to another WW Div. Resigned from Company Trans, to another WW Div. Retired from Company Trans, to another WW Div. Trans, to another WW Div. Trans, to another WW Div.
4.45
x 100 = 39.1% average decrease over 686 days (1.9 yr.) 50.0% average decrease would occur over 877 days (2.4 yr.)
* Sanple was collected 4 months before individual left TEFLON*. All other results in this column represent the blood C-8 level at the time individual left TEFLON*.
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