Document 21700RxoJ1JVEw8rLrRaxnzp

AR226-3200 H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations__________________DuPont-5368 % TRADE SECRET Study Title H-24516: Subchronic Toxicity with One9-G0-eDnearyaGtioanvaRgeepSrotudduyctiinonRaEtvsaluations Volume 4 of 5 Laboratory ProjectID: DuPont-5386 Test G uidelines: UO.PSP.TESPA87H0.e3a1lt0h0E(1f9fe9c8ts) Test Guidelines AUTHOR: Gregory S. Ladies, Ph.D., D.A.B.T. Study Completed on: December 3,2001 Performing Laboratory: EH.aI.skdeullPLoanbtodreatNoerymfoourrTsoaxnidcoCloogmypaanndy Industrial Medicine NElekwtoanrkR, oDaedl,awP.aOre. B1o9x71540-0050 ImilW ork Request Number: 0*Service C ode N um ber Spo nsor Study N um ber:' ) Page 970 of 1500 . Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643330 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, .PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE # DuPont-5386 971 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643336 Unscheduled Sacrifice Duration of dosing-days: 105. Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : KIDNEYS : CALCULUS\CALCULI, BILATERAL, severe. URINARY BLADDER : CALCULUS\CALCULI , severe. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : MINERALIZATION, mild. NECROSIS, TUBULAR, mild. HYPERPLASIA, TRANSITIONAL CELL, moderate. INFLAMMATION, ACUTE, mild. THYMUS : ATROPHY, mild. 643336 Continued on the next page .... DuPont-5386 H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643336 Continued from previous page Histopathology : URINARY BLADDER : HYPERPLASIA, SIMPLE, TRANSITIONAL CELL, moderate. INFLAMMATION, SUBACUTE/CHRONIC, mild. HEMORRHAGE, mild. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643354 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643354 Continued on the next page .... 973 Company Sanitized. Does not contain TSCA CBI # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643354 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643361 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643361 Continued on the next page .... # DuPont-5386 974 Company Sanitized. Does not contain TSCA CBI ## H90--2D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643361 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, 'LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE # DuPont-5386 975 Sanitized, Does not contain TSCA CBI m H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643362 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : NECROSIS, FOCAL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. m DuPont-5386 643362 Continued on the next page .... 976 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643362 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643374 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643374 Continued on the next page .... DuPont-5386 977 eenpamjp S an itized, oes not contain Y S C A CBS H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Genration Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643374 Continued from previous page Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. 643377 No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 'PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : PITUITARY GLAND : LARGE. 643377 Continued on the next page .... DuPont-5386 978 Company Sanitized. Does not contain TSCA CBI ## H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS . Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643377 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 979 Company Sanitized. Does notcontain TSCA CBI # H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643383 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, .THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. DuPont-5386 980 Company Sanitized. Does not contain TSCA CB1 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations__________ _____________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643384 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 981 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref 643387 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, -Ph a r y n x /l a r y n x , e y e (s ) w i t h o p t i c n e r v e , s k i n , m a m m a r y GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE, MANDIBLE # DuPont-5386 982 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643398 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. PARATHYROID GLANDS : NOT PRESENT. 643398 Continued on the next page .... 0 DuPont-5386 983 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643398 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643402 .Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 643402 Continued on the next page DuPont-5386 984 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643402 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 643405 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. 643405 Continued on the next page .... 985 Does not contain TSCA BI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643405 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643406 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 643406 Continued on the next page .... 986 Company Sanitized. P oes not contain TSCA CBI ## H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643406 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643415 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : PITUITARY GLAND : LARGE. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, 643415 Continued on the next page .... 987 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643415 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PITUITARY GLAND : - HYPERPLASIA, DIFFUSE, mild. NOSE : SQUAMOUS HYPERPLASIA, NASOLACRIMAL DUCT, mild. 643425 No Microscopic Abnormality Observed : LIVER, THYROID GLAND, MANDIBLE Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND 643425 Continued on the next page .... 988 Company Sanitized. Does not contain TSCA CB| ## 9H0--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643425 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : HYDRONEPHROSIS, BILATERAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643426 . Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643426 Continued on the next page .... 989 DuPont-5386 # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643426 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643436 Terminal Sacrifice Killed on Day : 93 Exposure Group : 9O-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643436 Continued on the next page 990 not confab) TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643436 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CYST, minimal. HEART : CARDIOMYOPATHY, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE # DuPont-5386 991 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643448 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE, MANDIBLE # DuPont-5386 992 Does not contain TSCACBI 9H0--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref 643453 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, -PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CYST, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE, MANDIBLE DuPont-5386 993 IBompany Sanitized. Does not contain TSCACBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643463 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. LUNGS : THROMBUS, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 643463 Continued on the next page .... 994 DuPont-5386 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643463 Continued from previous page Histopathology No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643465 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal 643465 Continued on the next page .... DuPont-5386 995 Company Sanitized. Does not contain TSCA CBt J901--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643465 Continued from previous page Histopathology : NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. 643477 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, 'BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. 643477 Continued on the next page .... # DuPont-5386 996 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643477 Continued from previous page Histopathology : PARATHYROID GLANDS : NOT PRESENT. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC . NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643484 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643484 Continued on the next page .... 997 Company Sanitized. Does not contain TSCA CBf # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643484 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. 643486 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643486 Continued on the next page .... DuPont-5386 998 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643486 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. MESENTERIC LYMPH NODE : NOT PRESENT. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL.MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE DuPont-5386 999 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643321 Unscheduled Sacrifice Duration of dosing-days: 29 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, BILATERAL, PELVIS, moderate. DISCOLORATION, TAN, BILATERAL, GRANULAR . URINARY BLADDER : DILATATION, severe. CALCULUS\CALCULI, 7MM DIA. No.Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : HYDRONEPHROSIS, BILATERAL, mild. INFLAMMATION, ACUTE, moderate. HYPERPLASIA, TRANSITIONAL CELL, mild. NECROSIS, TUBULAR, moderate. HEART : CARDIOMYOPATHY, minimal. 643321 Continued on the next page .... DuPont-5386 1000 Company Sanitized. Does not contain TSCA CBi H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females AAnniimmaall RReeff Microscopic & Macroscopic Findings 643321 Continued from previous page Histopathology : SPLEEN : DEPLETION, LYMPHOID, moderate. THYMUS : ATROPHY, moderate. URINARY BLADDER : HYPERPLASIA, SIMPLE, TRANSITIONAL CELL, moderate. BONE MARROW : ATROPHY, mild. MANDIBLE : .NOT PRESENT. No Microscopic Abnormality Observed : LIVER, LUNGS, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE DuPont-5386 1001 Company Sanitized. Does notcontain TSCACBj H90--2D45ay16G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643324 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : , INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does notcontain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643364 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : .... INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE, MANDIBLE DuPont-5386 1003 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643379 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY - -GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 643380 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643380 Continued on the next page .... DuPont-5386 1004 Company Sanitized. Does not contain TSCACBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643380 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : -INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643389 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643389 Continued on the next page .... 1005 Con>panySanHlzed. Does not contain TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic Sc Macroscopic Findings 643389 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : .ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. FRACTURE/CALLUS, TOOTH. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE 643390 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : ,,,,Tr,TMT LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643390 Continued on the next page DuPont-5386 1006 Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643390 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : .INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE, MANDIBLE 643391 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, a o r t a ' BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643391 Continued on the next page 1007 DuPont-5386 in TSCA CBf  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproducti.on Evaluations---------------------------- -------------------------------------------------------D--u-P--o-n--t---5-3--8-6-- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643391 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : ,,,,o THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES,.UTERUS, URINARY BLADDER, TTTSMT1R/KNEE JOINT. STERNUM, NOSE Histopathology : THYROID GLAND : .ALTERATION, COLLOID, minimal. 643396 Terminal Sacrifice Killed on Day : 93 Exposure Group : 9O-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM* PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, S X x / L A R Y N i , EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643396 Continued on the next page .... Doe# not contain TSGA CBl H90--2D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643396 Continued from previous page Histopathology LIVER : .. . INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : .. . NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE, MANDIBLE 643410 Terminal Sacrifice Killed on Day : 93 "Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643410 Continued on the next page DuPont-5386 H90--2D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643410 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 643433 No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643433 Continued on the next page DuPont-5386 1010 Company Sanitized. Does no! contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643433 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643437 Terminal Sacrifice -Killed on Day : 181 ' Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 643437 Continued on the next page DuPont-5386 1011 Company Sanitized. Does not contain TSCA CBI  ## H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations __________________ _--------------------------------------------------D--u--P-o-n-t---5--3-8--6- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643437 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 643458 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : .. t INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 643458 Continued on the next page .... Company Sanitized. Does not contain TSCA CB1 00 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations___________ _____________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643458 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643483 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, moderate. DuPont-5386 1013 Company Sanitized. Does not contain TSCA CBI H90-2-D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction E valuations________________________ ______________ -_______________D_u--P-o-n--t---5-3--8-6- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643322 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, - THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : NOSE : ., DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LIVER, KIDNEYS, THYROID GLAND, MANDIBLE 1014 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643323 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, -THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : .. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE, MANDIBLE DuPont-5386 H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643360 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, .THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. DuPont-5386 1016 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643366 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 1017 Company Sanitized. Does not contain TSCA CBI #.. . # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_____ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643367 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, MANDIBLE # DuPont-5386 1018 Company Sanitized. Does not contain TSCA CBI # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643373 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE DuPont-5386 1019 Company Sanitized. Dom not contain TSCA CB1 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations___________ ________________________________ ____________ DuPont-538( INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643381 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, minimal. 1020 Company SanitizedI. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643382 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, .THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND, NOSE 643392 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : LUNGS : DISCOLORATION, DARK. 643392 Continued on the next page .... DuPont-5386 1021 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643392 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, .STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS * NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : LUNGS, THYROID GLAND, NOSE, MANDIBLE DuPont-5386 1022 Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group :: VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643409 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, .THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, - PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, MANDIBLE DuPont-5386 1023 Company Sanitized. Does not contain TSCA CBI  H90--2D45ay16G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations _________________________________ ___________ ________ DuFon.tOJgg INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643412 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 1024 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643461 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 1025 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643462 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY 'GLAND (FEMALE) , OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC,.minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 1026 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643472 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, MANDIBLE DuPont-5386 1027 Does not contain TSCA CBi H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643489 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN,.SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 1028 o>npany Sanitized. Does not contain TSCA CBI  0.. H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643329 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, minimal. DuPont-5386 1029 TMpany Sanitized. Does not contain TSGA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643332 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, "PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643332 Continued on the next page .... DuPont-5386 1030 Company SanFHzed. Does not contato TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings Animal Ref Microscopic & Macroscopic Findings 643332 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), ' OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643340 Found Dead Duration of dosing-days: 69 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : ADRENAL GLANDS : LARGE, BILATERAL, moderate. WHOLE BODY : Autolysis: tissues taken, severe. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 643340 Continued on the next page 1031 DuPont-5386 notcontain TSCA CBl H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643340 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : SPLEEN : DEPLETION, LYMPHOID, mild. JEJUNUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, moderate. THYMUS : ATROPHY, severe. PARATHYROID GLANDS : NOT PRESENT. E Y E (S ) WITH OPTIC NERVE : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION, AMELOBLASTS, mild. MANDIBLE : NOT PRESENT. DuPont-5386 643340 Continued on the next page .... 1032 Company Sanitized. Does not contain TSCA CBi H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643340 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, .EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643341 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643341 Continued on the next page .... # DuPont-5386 1033 Company Sanitized. Does not contain TSCA CBI fll H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643341 Continued from previous page Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. SPLEEN : NOT PRESENT. THYROID GLAND : ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : KIDNEYS,' LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW # DuPont-5386 1034 Company Sanitized. Does not contain TSCA CBi H90--2D4a5y16G: aSvaugbechSrtoiindiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643345 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, -"PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 1035 Company Sanitized. Does net eontsfn ts**a RRi 9H0--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643347 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ` 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, MANDIBLE DuPont-5386 1036 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref 643351 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, -PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LIVER, KIDNEYS, NOSE, MANDIBLE DuPont-5386 1037 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643356 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. DEGENERATION, AMELOBLASTS, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. # DuPont-5386 1038 Company Sanitized. Does not contain TSCA CB1 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations___________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643358 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 1039 Company S a n d ed . Does no! contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643359 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, - 'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, minimal. . PARATHYROID GLANDS : NOT PRESENT. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643359 Continued on the next page .... DuPont-5386 1040 Company SanWzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643359 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643368 'Accidentally Killed Duration of dosing-days: 53 Exposure Group : REPRODUCTION Animal is signed off from necropsy Gross Pathology : ESOPHAGUS : PUNCTURE, GAVAGE ERROR. SKIN : STAIN. RED, PERINEUM. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643368 Continued on the next page .... DuPont-5386 1041 Company Sanitized, Does not contain TSCA CfM H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643368 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. SPLEEN : 'DEPLETION, LYMPHOID, mild. JEJUNUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, moderate. THYMUS : ATROPHY, severe. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, severe. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, severe. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : NOT PRESENT. DuPont-5386 643368 Continued on the next page .... 1042 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643368 Continued from previous page Histopathology : No Microscopic Abnormality observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM 643370 ''Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643370 Continued on the next page .... DuPont-5386 1043 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643370 Continued from previous page Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : INFARCT, minimal. NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. MESENTERIC LYMPH NODE : NOT PRESENT. PARATHYROID GLANDS : NOT PRESENT. EYE'(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW DuPont-5386 1044 Sanitized. Dom notcontain TSCACEU TT-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643388 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, - 'PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : HYPERPLASIA/SQUAMOUS METAPLASIA, minimal. TRANSITIONAL CELL, DuPont-5386 1045 Company Sanitized. Does not contain TSCA CB1 H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 rag/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643404 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, -KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, --PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, moderate. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. 643404 Continued on the next page .... DuPont-5386 1046 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643404 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, MANDIBLE 643408 -'Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 643408 Continued on the next page .... DuPont-5386 1047 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Tpxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643408 Continued from previous page Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW # DuPont-5386 1048 Company S an d ed . Does not contain TSCA CB1 H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643423 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, --PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 1049 Company Sanitized- Doe*not contain TSCA CBI 9H0--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII 250 mg/kg/day Sex: Females Animal Ref Microscopie & Macroscopie Findings 643435 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, minimal. URINARY BLADDER : NOT PRESENT. 643435 Continued on the next page .... DuPont-5386 1050 Company Sanitized. Does not contain TSCACBj H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643435 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643441 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643441 Continued on the next page .... DuPont-5386 1051 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643441 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATt y CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 1052 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643444 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, .. THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 1053 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643446 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, mild. PARATHYROID GLANDS : NOT PRESENT. E Y E (S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. 643446 Continued on the next page .... DuPont-5386 1054 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643446 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, ' SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643450 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643450 Continued on the next page .... DuPont-5386 1055 Company Sanitized. P ees not contain TSCA CBI m H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations # ____________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643450 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, minimal. 643456 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643456 Continued on the next page .... 1056 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643456 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT, mild. No Microscopic Abnormality Observed : MANDIBLE # DuPont-5386 1057 Does notcontain TSCACBJ # H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643466 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. MESENTERIC LYMPH NODE : NOT PRESENT. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, mild. E Y E (S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. 643466 Continued on the next page ... # DuPont-5386 1058 Company Sanitized. Does not contain TSCACBI # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref 643466 Microscopic & Macroscopic Findings Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643474 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643474 Continued on the next page .... # DuPont-5386 1059 Company SanWzed. Does noconiata TSCA CBI # ' H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_____ ___________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643474 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643481 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed, off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643481 Continued on the next page .... 1060 Company Sanitized. Does not contain TSCA CBf # # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643481 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS.: NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : MANDIBLE 1061 Company Sanitized. Does not contain TSCA CBI # H90--2D45ay16G: aSvaugbehSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643487 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE DuPont-5386 1062 Company SanIHzed. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX O REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Pi MALE RATS m 1063 Company Sanitized. Does not eontafn TSC CBf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Pi MALE RATS EXPLANATORY NOTES Notes: Test Days 75-89 = Cohabitation period DuPont-5386 1064 Company SanWzed. Does not contain TSCA CBI H90--2D45a1y6G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pi MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 78 85 92 99 106 602.8 514.2 515.9 624.5 465.5 441.0 522.9 564.4 507.3 560.0 635.1 525.9 651.7 565.1 587.4 524.9 582.0 562.8 677.2 482.3 614.2 539.7 520.4 644 ...1 480.7 454.9 533.6 575.4 522.7 578.7 636.5 540.9 675.1 580.0 591.1 539.2 597.9 574.2 696.9 494.6 627.7 552.6 539.2 647.5 484.6 465.7 556.8 595.5 528.4 586.8 649.3 551.5 692.9 596.4 617.3 557.9 601.1 587.9 716.4 512.6 625.4 562.6 556.3 664.9 506.3 482.6 569.3 608.0 538.7 598.1 669.5 570.5 704.6 604.4 627.2 563.1 613.8 600.1 725.5 522.5 648.8 569.4 569.5 681.1 513.3 493.0 575.8 626.0 541.9 614.9 676.4 582.0 716.0 617.4 637.9 577.1 631.2 605.8 738.2 536.8 % 1065 Company SanWzed. Does no! contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 78 85 92 99 106 469.8 626.4 495.5 570.3 477.4 606.8 566.9 589.6 549.5 529.1 558.2 623.5 574.0 464.8 554.3 517.3 465.1 584.7 569.3 484.8 473.5 641.6 .. 513.5 568.3 485.6 619.3 567.9 607.3 568.7 542.3 578.2 637.1 581.1 460.9 579.6 525.8 480.6 582.7 590.0 502.0 480.6 660.3 530.1 583.2 496.3 642.7 583.2 624.1 580.6 558.4 585.8 643.9 596.7 472.6 583.1 530.9 493.3 594.2 615.9 520.0 490.8 679.0 538.7 597.3 504.1 662.5 595.4 646.7 597.8 577.8 583.8 653.0 614.6 495.0 597.7 533.7 511.3 605.3 629.5 529.5 495.4 695.9 541.3 610.4 513.9 676.7 612.9 657.4 613.5 588.6 592.1 660.5 623.5 476.9 605.2 544.7 518.4 614.2 636.2 532.8 1066 Company SanWzed. Does no! contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pj. MALE RATS GROUP: V-0 ' DOSE: 100 MG/KG/DAY test DAYS: ANIMAL NUMBER 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 . 78 85 92 99 106 511.6 566.3 558.8 512.4 543.0 547.4 592.5 507.2 466.6 545.1 560.7 601.1 552.8 538.6 568.5 592.7 499.6 606.0 526.7 553.2 515.1 590.0 576.7 523.6 556.5 568.7 614.7 516.6 474.0 561.9 576.0 600.0 571.6 546.3 582.1 604.7 505.8 618.5 530.6 551.9 527.8 604.1 597.7 533.3 551.1 572.7 622.7 529.3 489.0 581.2 592.4 619.0 585.7 538.2 591.1 616.0 520.2 633.6 531.9 552.4 538.8 630.8 611.8 541.9 552.8 584.7 629.1 551.4 496.6 586.5 605.6 637.4 599.9 538.8 601.2 626.2 495.1 645.2 540.9 567.7 536.6 636.4 610.9 550.9 554.2 561.4 581.4 542.0 493.4 600.9 610.9 640.7 605.3 537.4 616.0 640.0 497.4 637.4 465.9 563.9 1067 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pi MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643281 78 85 92 99 106 403.6 536.3 577.3 499.4 505.7 429.6 443.7 490.4 477.9 491.0 542.1 513.5 481.5 509.4 513.3 578.4 433.6 447.6 530.5 431.4 572.0 596.1 528.9 542.4 457.8 457.6 501.4 506.7 508.7 563.5 512.7 485.4 519.2 539.0 599.4 473.5 472.1 538.9 440.0 592.9 615.9 554.9 567.1 464.5 473.0 507.7 516.6 511.0 579.1 529.7 489.5 538.3 559.3 626.8 500.5 478.8 544.8 449.3 611.8 624.7 565.8 576.1 419.4. 480.5 523.8 524.6 515.1 597.4 536.6 498.4 528.8 574.6 654.0 524.6 486.1 548.6 454.2 627.6 632.1 576.7 587.0 397.7 495.4 534.0 538.4 518.9 604.5 538.3 505.3 529.7 584.5 674.5 540.6 496.8 560.8 Does not contain TSCA CBf H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX P REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS 10! I. Does not contain TSCA CBf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations______________ REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS EXPLANATORY NOTES Notes: Test Days 75-89 = Cohabitation period DuPont-5386 1070 H90--2D4a5y16G:avSaugbechSrtoundiyc TinoRxiactistywith One-GenerationReproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643254 78-85 85-92 92-99 99-106 78-106 11.4 25.5 4.5 19.6 15.2 13.9 10.7 11.0 15.4 18.7 1.4 15.0 23.4 14.9 3.7 14.3 15.9 11.4 19.7 12.3 13.5 12.9 18.8 3.4 3.9 10.8 23.2 20.1 5.7 8.1 12.8 10.6 17.8 16.4 26.2 18.7 3.2 13.7 19.5 18.0 -2.3 10.0 17.1 17.4 21.7 16.9 12.5 12.5 10.3 11.3 20.2 19.0 11.7 8.0 9.9 5.2 12.7 12.2 9.1 9.9 23.4 6.8 13.2 16.2 7.0 10.4 6.5 18.0 3.2 16.8 6.9 11.5 11.4 13.0 10.7 14.0 17.4 5.7 12.7 14.3 46.0 55.2 53.6 56.6 47.8 52.0 52.9 61.6 34.6 54.9 41.3 56.1 64.3 52.3 50.5 52.2 49.2 43.0 61.0 54.5 1071 Company Sanitized. Does not contain TSCA CB1 H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 78-85 85-92 92-99 99-106 78-106 3.7 15.2 18.0 - 2.0 8.2 12.5 1.0 17.7 19.2 13.2 20.0 13.6 7.1 -3.9 25.3 8.5 15.5 - 2.0 20.7 17.2 7.1 18.7 16.6 14.9 10.7 23.4 15.3 16.8 11.9 16.1 7.6 6.8 15.6 11.7 3.5 5.1 12.7 11.5 25.9 18.0 10.2 18.7 8.6 14.1 7.8 19.8 12.2 22.6 17.2 19.4 - 2.0 9.1 17.9 22.4 14.6 2.8 18.0 11.1 13.6 9.5 4.6 162.. 69 13.1 9.8 14.2 17.5 10.7 15.7 10.8 8.3 7.5 8.9 -18.1 7.5 11.0 7.1 8.9 6.7 3.3 25.6 69.5 45.8 40.1 36.5 69.9 46.0 67.8 64.0 59.5 33.9 37.0 49.5 12.1 50.9 27.4 53.3 29.5 66.9 48.0 % 1072 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pj. MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643313 643182 . 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 . 78-85 85-92 92-99 99-106 78-106 3.5 23.7 17.9 11.2 13.5 21.3 22.2 9.4 7.4 16.8 15.3 -1.1 18.8 7.7 13.6 12.0 6.2 12.5 3.9 -1.3 12.7 14.1 21.0 9.7 -5.4 4.0 8.0 12.7 15.0 19.3 16.4 19.0 14.1 -8.1 9.0 11.3 14.4 15.1 1.3 0.5 11.0 26.7 14.1 8.6 1.7 12.0 6.4 22.1 7.6 5.3 13.2 18.4 14.2 0.6 10.1 10.2 -25.1 11.6 9.0 15.3 -2.2 5.6 -0.9 9.0 1.4 -23.3 -47.7 -9.4 -3.2 14.4 5.3 3.3 5.4 -1.4 14.8 13.8 2.3 -7.8 -75.0 -3.8 25.0 70.1 52.1 38.5 11.2 14.0 -11.1 34.8 26.8 55.8 50.2 39.6 52.5 -1.2 47.5 47.3 -2.2 31.4 -60.8 10.7 1073 Company Sanitized. Does not contain TSCA CM 9H0--2D45ay16G:aSvaugbechSrtoundiyciTnoRxaictsitywith One-GenerationReproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY TEST DAYS: 78-85 85-92 92-99 99-106 78-106 ANIMAL NUMBER 643289 27.8 8.6 9.3 4.9 50.6 643171 35.7 20.9 18.9 15.8 91.3 643158 18.8 19.8 8.8 7.4 54.8 643249 29.5 26.0 10.9 10.9 77.3 643161 36.7 2417 9.0 10.9 81.3 643248 28.2 6.7 -45.1 -21.7 -31.9 643285 13.9 15.4 7.5 14.9 51.7 643278 11.0 6.3 16.1 10.2 43.6 643299 28.8 9.9 8.0 13.8 60.5 643274 17.7 2.3 4.1 3.8 27.9 643192 , 21.4 15.6 18.3 7.1 62.4 643222 -0.8 17.0 6.9 1.7 24.8 643160 3.9 4.1 8.9 6.9 23.8 643191 9.8 19.1 -9.5 0.9 20.3 643203 25.7 20.3 15.3 9.9 71.2 643282 21.0 27.4 27.2 20.5 96.1 A 643302 643317 643281 39.9 24.5 8.4 27.0 6.7 5.9 24.1 7.3 3.8 16.0 10.7 12.2 107.0 49.2 30.3 m 1074 Company Sanitized. Does not contai_n TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX Q REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION 1075 Company Sanitized. Does not contain TSCA CBI 9H0--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P! FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter delivered; data excluded from statistical analysis. b c d No gestation data since no copulation plug was observed; no litter was delivered. NaDnoaatlalyitsntieosr.tdceollilveecrteedd,dhuoewtoeveerrr,oirm. plants were observed at necropsy. Data was excluded from statistical /e NDaomgedsetalitvioenreddaptariosirntcoecnoollpelcutigown aosf oDbasyer2v1eGd,bhoodwyewveerigahlti.tter was delivered. g Accidentally killed Test Day 91 (Day 14G). 1076 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643319*5 643350a 643363 643397 643421 643420a 643419 643414* 643401 643455 643378 643393*5 643447 643478 643386 0 7 14 21 306.1 274.2 318.3 302.2 304.6 - 306.1 336.7 311.1 269.9 365.6 357.8 343.8 269.6 281.1 359.5 - 322.0 281.7 287.7 328.9 294.4 355.7 333.8 334.7 311.0 361.8 332.2 301.7 403.0 396.0 381.6 299.9 313.9 383.3 - 350.3 308.9 308.0 339.3 322.4 382.0 344.3 363.5 327.3 400.1 369.3 339.6 426.8 428.2 416.5 332.9 340.2 419.9 - 394.3 340.8 337.5 322.7 394.4 478.0 349.9 451.6 318.2 476.5 -C _c 397.9 533.9 370.9 421.3 444.7 471.9 - -C 433.1 426.7 1077 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479e 643403e 643376 643422<3 643452 643475 643372 643400 643395 643457 0 7 14 21 307.2 292.4 327.7 309.8 301.0 345.8 306.5 391.8 303.8 363.9 - 297.8 315.9 349.0 336.1 345.7 315.4 275.4 289.7 307.2 341.6 317.4 348.1 352.4 340.4 375.2 325.8 415.8 335.6 404.7 - 323.0 336.2 374.6 375.7 374.3 339.9 287.3 316.7 339.9 366.8 358.6 386.5 386.7 375.9 412.3 345.9 434.8 364.5 388.7 333.3 368.6 401.0 392.3 383.9 358.4 322.4 339.3 368.8 447.7 -C _C 499.2 437.9 511.0 408.7 422.7 451.1 555.5 313.9 _f 400.1 445.3 386.7 489.6 371.4 -C _C % 1078 Company Sanft'zed. Does notconfo'n TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470'fr 643434 643349 643454 643333 0 7 14 21 312.5 288.9 321.4 294.8 310.0 310.4 304.7 274.2 315.0 271.5 326.2 278.6 313.6 271.9 297.8 304.1 312.3 266.4 309.6 338.6 311.2 348.9 327.5 346.8 312.8 333.5 288.1 341.1 301.1 358.4 283.3 336.7 299.6 338.9 345.1 342.2 311.5 331.7 371.2 326.3 379.2 360.1 381.7 331.6 363.9 301.6 377.7 329.5 405.3 287.5 366.4 333.8 433.2 308.7 455.2 463.4 452.3 301.9 _C 296.6 . _c 385.2 _C 282.7 410.5 381.4 362.3 376.0 .373.7 345.5 363.1 454.8 498.7 _c 373.0 451.8 1079 Company Sanitized. Does no! contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335e 643468 643440 643430a 643431* 643326 643365 643375 643328 643348a 643346 643449 643429 643424a 14 21 276.6 255.0 331.7 284.5 295.4 - 273.8 292.0 272.4 - 312.0 318.5 312.8 302.1 265.7 307.5 328.1 314.1 240.8 319.8 300.5 364.9 307.1 322.1 - 310.0 327.6 280.6 - 325.1 350.8 361.7 346.1 276.0 263.6 361.6 348.0 267.8 345.2 336.0 399.2 341.1 354.6 347.3 363.4 282.2 362.0 369.8 401.2 384.5 283.4 -9 386.4 382.6 281.8 436.3 415.1 495.7 433.6 447.5 440.3 476.6 267.0 443.6 435.4 _c _c 283.7 -9 493.9 371.4 283.8 % 1080 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX R REPRODUCTIVE TOXICOLOGY _ INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION 1081 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter delivered; data excluded from statistical analysis. b No gestation data since no copulation plug was observed; no litter was delivered. cd e NNDoaotlaigtnteeosrttdaceotliliolveencrteeddda,dthauoewsitenovceeerrr,onirmo. pplalnutgs wweares oobbsseervrevdedat,nheocrwopesvye.rDaaltiattwearswexacsluddeeldivfreormeds.tatistical analysis. / Dam delivered prior to collection of day 21G body weight. g Accidentally killed Test Day 91 (Day 14G). 1082 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643319-k 643350a 643363 643397 643421 643420a 643419 643414*3 643401 643455 643378 643393-k 643447 643478 643386 01 7-14 14-21 0-21 22.8 20.2 37.4 31.6 30.1 - 4.9 25.1 21.1 31.8 37.4 38.2 37.8 30.3 32.8 23.8 - 28.3 27.2 20.3 10.4 28.0 26.3 10.5 28.8 '16.3 38.3 37.1 37.9 23.8 32.2 34.9 33.0 26.3 36.6 44.0 31.9 29.5 -16.6 72.0 96.0 5.6 88.1 -9.1 76.4 -C _c -28.9 105.7 -45.6 88.4 104.5 52.0 -C 92.3 89.2 16.6 120.2 159.7 47.7 147.0 12.1 139.8 -C -C 32.3 176.1 27.1 151.7 163.6 112.4 - -C 151.4 139.0 i 1083 Company Sanitized. Does not contain TSCACB_ i H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING GESTATION GROUP: IV-0 . DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479e 643403a 643376 643422*3 643452 643475 643372 643400 643395 643457 O 1 o 7-14 14-21 0-21 34.4 25.0 20.4 42.6 39.4 29.4 19.3 24.0 31.8 40.8 - 25.2 20.3 25.6 39.6 28.6 24.5 11.9 27.0 32.7 25.2 41.2 38.4 34.3 35.5 37.1 20.1 19.0 28.9 -16.0 - 10.3 32.4 26.4 16.6 9.6 18.5 35.1 22.6 28.9 80.9 -C -C 112.5 62.0 98.7 62.8 -12.1 86.6 166.8 - -19.4 -0.9 53.0 2.8 131.2 49.0 ' -C -C 140.5 -C -C 189.4 136.9 165.2 102.2 30.9 147.3 191.6 16.1 _f 51.1 109.2 41.0 174.2 96.0 _C _C 1084 Company Sanitized. Does n0, contain TSCACBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pa FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470-fr 643434 643349 643454 643333 643460 0-7 7-14 14-21 0-21 26.1 22.3 27.5 32.7 36.8 2.4 28.8 13.9 26.1 29.6 32.2 4.7 23.1 27.7 - 41.1 41.0 29.9 45.1 22.1 32.6 15.1 30.3 32.6 34.9 18.8 30.4 13.5 36.6 28.4 46.9 4.2 29.7 34.2 23.4 30.9 31.5 34.0 31.4 62.0 -17.6 76.0 103.3 70.6 -29.7 -C -5.0 -C 55.7 -C -4.8 44.1 47.6 92.5 122.7 _c 27.5 88.7 120.7 19.8 133.8 168.6 142.3 -8.5 _c 22.4 _c 113.7 _c 4 .1 96.9 109.5 157.0 194.6 _c 106.6 142.2 1085 Company Sanitized. Does notcontainTSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY m GESTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335e 643468 643440 643430a 643431* 643326 643365 643375 643328 643348a 643346 643449 643429 643424a 0-7 7-14 14-21 0-21 43.2 45.5 33.2 22.6 26.7 36.2 35.6 8.2 - 13.1 32.3 48.9 44.0 10.3 -43.9 33.5 33.9 27.0 25.4 35.5 34.3 34.0 32.5 37.3 ' 35.8 1.6 36.9 19.0 39.5 38.4 7-g.4 24.8 34.6 14.0 91.1 79.1 96.5 92.5 92.9 93.0 113.2 -15.2 81.6 65.6 -C -C 0-g.3 107.5 -11.2 2.0 159.7 160.1 164.0 149.1 152.1 166.5 184.6 -5.4 131.6 116.9 _C _C 18-g.0 165.8 57.3 43.0 % 1086 Company Sanitized. Does not contain TSCA C8` H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX S REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF ?i FEMALE RATS DURING LACTATION 1087 Company Sanitized. Doss not contain TSCA CSf H90--2D45ay16G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No litter delivered. b Nstaotilsittitcearldaenliavleyrseisd., however, implants were observed at necropsy. Data was excluded from c d e AFocucniddenDteaalldyTkeilslteDd Tayes9t9D(aDya9y12(2DGa)y. 14G). Found dead Test Day 106 (Lactation Day 0). % 1088 Company Sanitized. Does not contain TSCA C61 H90--2D45ay16G:avSaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: II-0 DOSE: 0 MG/KG/DAY LACTATION DAYS : ANIMAL NUMBER 0 7 14 21 643352a 643343 643459 643394a 643480 643319a 643350a 643363 643397 643421 643420a 643419 643414-b 643401 643455 643378 643393a 643447 643478 643386 - 297.4 360.5 - 331.7 - - 367.4 356.1 320.1 - 412.6 - 312.9 305.9 389.9 - 387.7 320.5 329.0 - 319.1 378.4 _ 353.2 - - 380.0 300.2 320.1 - 398.0 - 324.1 327.2 372.2 - 376.9 321.5 339.2 - 335.8 392.7 _ 361.0 - _ 392.4 358.8 283.8 - 414_ .8 338.7 343.3 375.9 - 387.2 355.5 347.9 - 336.3 377.8 _ 330.8 - _ 379.1 361.1 286.3 - 402.9 _ 324.0 331.8 376.7 - 365.9 339.1 354.3 1089 Company Sanitized. Does not contain T$CA CBI H90--2D45ay16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479 643403a 643376 643422^ 643452 643475 643372 643400 643395 ' 643457 0 7 14 21 340.9 328.5 369.8 360.2 325.7 381.6 336.3 - 352.7 435.4 341.2 - 343.9 - 324.7 367.9 363.1 301.4 336.2 368.5 352.7 346.8 306.1 375.6 354.9 377.3 339.9 - 353 .4 434.8 301.7 - 337.0 - 334.1 372.6 347.0 322.5 345.5 370.5 387.6 370.7 385.7 398.1 388.4 397.8 368.7 - 368.1 431.8 370.2 - 371.9 - 375.4 394.0 374.3 344.7 364.6 383.5 342.4 355.0 391.5 377.9 353.7 381.8 352.0 - 346.4 405.7 358.6 - 366.9 - 375.0 388.9 346.7 356.0 350.5 371.1 1090 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470a 643434 643349 643454e 643333 643460 0 7 14 21 376.8 - 354.8 353.1 379.7 - 338.5 - 367.8 330.7 318.1 - 294.7 292.9 - 335.9 354.1 - 270.6 353.6 371.7 - 374.9 353.0 374.0 - 346.9 - 373.5 319.5 328.4 - 345.0 334.4 - 355.2 369.3 - 341.2 313.3 370.7 - 390.6 374.6 393.0 - 378.5 - 389.2 350.1 341.4 - 379.3 341.2 - 376.9 390.1 - 371.2 353.0 367.8 - 380.6 363.0 360.9 - 353.0 - 381.7 341.5 356.3 - 378.3 329.2 - 360.8 365.2 - 346.8 360.0 1091 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 643326 643365 643375 643328 643348a 643346^ 643449 643429e 643424a 0 7 14 21 345.3 316.1 388.9 324.2 328.8 328.7 319.8 345.3 - - 336.2 353.2 365.3 327.5 - - 363.0 - - 350.1 331.3 408.9 343.5 341.2 359.9 322.9 304.2 - - 348.6 353.4 366.3 340.3 - - 370.6 - - 362.8 352.8 415.0 348.9 371.8 319.0 348.4 384.3 - - 375.2 371.2 368.3 305.6 - - 391.2 - - 345.4 259.3 306.4 283.6 357.6 362.4 319.3 390.6 - - 361.5 380.5 378.7 312.4 - - 377.1 - - % 1092 Company Sanitized. Does not contain TSCA CBi 9H0--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX T REPRODUCTIVE TOXICOLOGY m INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING LACTATION 1093 Company Sanitized. Does not contain TSCACBI H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations DuPont-5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No litter delivered. b Nstaotilsittticearldaenliavleyrseisd., however, implants were observed at necropsy. Data were excluded from c d e AFocucniddeDnteaalldyTkeilsltedDTayes9t9D(aDya9y122(DGa).y 14G). Found Dead Test Day 106 (Lactation Day 0). 1094 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: II-0 DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643319a 643350a 643363 643397 643421 643420a 643419 643414-b 643401 643455 643378 643393a 643447 643478 643386 0-7 7-14 14-21 0-21 21.7 17.9 21.5 - - 12.6 -55.9 0.0 -14.6 - 11.2 21.3 -17.7 - -10.8 1.0 10.2 16.7 14.3 - 7.8 - 12.4 58.6 -36.3 16.8 - 14.6 16.1 3.7 10.3 34.0 8.7 0.5 -14.9 -. -30.2 - -13.3 2.3 2.5 - -11.9 - -14.7 -11.5 0.8 -21.3 -16.4 6.4 38.9 17.3 -0.9 - 11.7 5.0 -33.8 -9.7 - 11.1 25.9 -13.2 -21.8 18.6 25.3 1095 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY LACTATION DAYS: 0-7 ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479 643403a 643376 643422> 643452 643475 643372 643400 643395 643457 11.8 18.3 -63.7 . 15.4 29.2 -4.3 3.6 - 0.7 -0.6 -39.5 - -6.9 - 9.4 4.7 -16.1 21.1 9.3 2.0 7-14 14-21 0-21 34.9 23.9 79.6 22.5 33.5 20.5 28.8 - 14.7 -3.0 68.5 - 34.9 - 41.3 21.4 27.3 22.2 19.1 13.0 -45.2 -15.7 5.8 -20.2 -34.7 -16.0 -16.7 - -21.7 -26.1 -11.6 - -5.0 - -0.4 -5.1 -27.6 11.3 -14.1 -12.4 1.5 26.5 21.7 17.7 28.0 0.2 15.7 - -6.3 -29.7 17.4 _ 23.0 _ 50.3 21.0 -16.4 54.6 -14.3 2.6 1096 Company Sanitized. Does not contain TSCA CBI 9H0--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470a 643434 643349 643454e 643333 643460 0-7 -5.1 - 20.1 -0.1 -5.7 - 8.4 - 5.7 -11.2 10.3 - 50.3 41.5 - 19.3 15.2 - 70.6 -40.3 7-14 14-21 0-21 -1.0 _ 15.7 21.6 19.0 _ 31.6 - 15.7 30.6 13.0 - 34.3 6.8 _ 21.7 20.8 - 30.0 39.7 -2._ 9 -10.0 -11.6 -32.1 _ -25.5 -7.5 -8.6 14.9 _ -1.0 -12.0 _ -16.1 -24.9 _ -24.4 7.0 -9._ 0 25.8 9.9 -18._ 8 14.5 13.9 10.8 38.2 _ 83.6 36.3 24.9 11._ 1 76.2 6.4 1097 " cOoHmirpwannvySaSnafn|>iTti(zMe|d. .DDaoesno<tc->o--n-ta*in TSCAmGBi 7 H90--2D45ay16G:aSvaugbechSrtoundiyciTnoRxaictsitywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 643326 643365 643375 643328 643348a 643346^ 643449 643429e 643424a 0-7 7-14 14-21 0-21 4.8 15.2 20.0 19.3 12.4 31.2 3.1 -41.1 - - 12.4 0.2 1.0 12.8 - - 7.6 - - 12.7 21.5 6.1 5.4 30.6 -40.9 25.5 80.1 - - 26.6 17.8 2.0 -34.7 _ . 20.6 - _ -17.4 -93.5 -108.6 -65.3 -14.2 43.4 -29.1 6.3 _ _ -13.7 9.3 10.4 6._ 8 -14.1 - _ 0.1 -56.8 -82.5 -40.6 28.8 33.7 -0.5 45._ 3 25.3 27.3 13.4 -15.1 _ 14.1 _ _ 1098 Company Sanitized. Doesnotcontain TSCACB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX U REPRODUCTIVE TOXICOLOGY INDIVIDUAL DAILY FOOD CONSUMPTION BY Pj FEMALE RATS DURING GESTATION 1099 CompanySanitized. Doesnot contain TSCACBI H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION BY Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a b NNoo gliettsetratdioelnivdearteads;idnacteaneoxcplluudgewdafsroombssetravtiesdti;cnaol alintatelyrswisa.s delivered. c Nstaotilsittticearldaenliavleyrseisd., however, implants were observed at necropsy. Data were excluded from d e ANoccgideestnattailolny kdialtlaedsiTnceestnDoapylu9g1 w(Dasayob1s4eGrv).ed, however a litter was delivered. 1100 Company Sanitized. Doesnotcontain TSCACBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pj FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643319^ 643350a 643363 643397 643421 643420a 643419 643414e 643401 643455 643378 643393-b 643447 643478 643386 0-7 24.5 20.9 26.3 27.7 15.4 21.6 29.6 25.9 23.3 34.6 30.0 30.8 25.5 23.2 . 27.5 27.2 25.3 21.8 7-14 14-21 25.8 25.1 27.7 25.9 30.3 26.3 32.5 28.1 27.9 35.1 32.3 29.4 29.0 37.1 32.6 31.4 27.2 22.7 19.8 25.0 25.2 25.4 9.0 21.8 30.1 28.4 26.2 22.1 31.2 23.6 29.4 24.6 28.8 30.9 26.3 23.8 0-21 23.4 23.7 26.4 26.4 18.2 23.2 30.7 27.5 25.8 30.6 31.2 27.9 28.0 28.3 29.6 29.8 26.3 22.8 '" 1101 Company Sanitized. Does notcontain TSCACBt H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluat.ions DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pi FEMALE RATS during gestation GROUP: IV-0 DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479d 643403a 643376 643422e 643452 643475 643372 643400 643395 643457 0-7 7-14 14-21 0-21 23.8 24.1 .23.4 27.6 27.8 28.5 20.4 26.1 25.2 32.1 22.9 22.6 24.1 27.1 26.7 21.5 23.7 24.0 25.5 28.3 26.0 26.1 27.4 28.8 28.9 22.4 28.4 26.5 35.4 22.9 24.6 31.2 27.4 26.2 22.3 24.1 23.5 28.5 27.8 27.3 27.1 24.6 27.0 29.1 26.4 6.5 24.8 37.1 19.5 26.4 29.3 26.6 24.4 32.5 25.0 22.9 26.4 26.6 25.8 25.5 26.5 27.9 28.8 23.1 20.3 25.5 34.9 21.7 24.6 28.2 27.0 25.8 25.4 24.3 23.5 26.8 % -------------------------------------------------------------------I2 Company Sanitized. Does notcontain TSCACBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY P! FEMALE RATS DURING GESTATION GROUP: VI-0 ' DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470^ 643434 643349 643454 643333 643460 0-7 7-14 14-21 0-21 26.8 22.5 25.6 25.2 28.3 21.0 26.8 22.3 23.3 24.9 27.9 17.7 22.9 22.8 30.0 25.6 26.7 26.9 23.8 32.4 24.2 27.7 28.8 30.1 22.4 27.6 22.8 29.8 27.5 30.7 21.2 27.2 25.0 29.5 16.8 26.7 28.1 30.5 18.3 28.7 19.0 33.4 27.0 26.8 18.2 22.3 23.4 28.0 26.7 28.1 29.8 . 26.9 26.3 21.5 26.6 26.6 28.1 29.6 21.2 26.7 27.4 29.6 20.6 27.7 21.3 28.8 26.4 28.5 19.1 24.1 23.7 28.1 24.6 27.1 27.8 26.3 1103 Company Sanitized. Does notcontain TSCACBf m H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pi FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335d 643468 643440 643430a 643431* 643326 643365 643375 643328 643348a 643346 643449 643429 643424a 0-7 7-14 14-21 0-21 32.1 25.5 27.0 29.1 25.3 - 26.7 28.9 25.4 - 25.1 29.6 27.7 30.5 24.0 14.3 31.0 22.5 19.4 30.2 . 26.3 26.4 28.6 29.4 27.7 29.5 22.1 - 27.7 30.5 31.7 32.2 24.2 36.8 26.1 25.3 22.7 31.7 23.8 24.3 18.7 32.4 28.9 26.3 17.3 28.7 27.0 30.0 27.0 23.9 _e 28.8 . 17.3 21.0 31.3 25.2 25.9 25.5 29.0 27.8 28.2 21.6 27.2 29.0 29.8 29.9 24.0 _e 28.7 21.7 21.0 m 1104 Company Sanitized. Does notcontain TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX V REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS m 1105 Company Sanitized- Does notcontain TSCCBl H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 . 643211 643163 643197 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA RIGHT FRONT PAW(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 85 85 92 108 1106 Company Sanitized. Does notcontain TSCACB) H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643242 643251 643155 643147 643276 643254 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 Company Sanitized. Does notcontain TSCACBI m H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 % '-- U8 Company Sanitized. Does notcontain TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643167 643223 643233 643183 643219 643263 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 Company Sanitized. Does not contain TSCACBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED . SACRIFICED BY DESIGN TEST DAY 107 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA LEFT FRONT PAW(S) ALOPECIA LEFT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED. SACRIFICED BY DESIGN TEST DAY 109 85 107 85 108 85 108 Company Samtaeo. uoes uncertain TSCACBl H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643227 643164 643154 643156 643208 643190 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 CompanySamtfced. Does no.oonUdnTSCACBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643289 643171 . 643158 643249 643161 643248 643285 643278 643299 643274 643192 . 643222 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 COLORED DISCHARGE RIGHT EYE(S) RED TEETH CLIPPED ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 TEETH CLIPPED SACRIFICED BY DESIGN TEST DAY 107 TEETH CLIPPED COLORED DISCHARGE NOSE BLACK COLORED DISCHARGE BOTH EYE(S) RED TEETH CROOKED COLORED DISCHARGE RIGHT EYE(S) RED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 TEETH CLIPPED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 85 92 85 85 99 107 99 107 85 85 85 92 99 106 99 106 99 108 108 108 85 85 1112 Company Sanitized, oes notcontain TSCACBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj. MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643160 643191 643203 643282 643302 643317 643281 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 TEETH CLIPPED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 8592 1113 Company San.U0. woes noicontain TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX W REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICDAULROINBGSEGREVSATTAITOINOSNIN Pi FEMALE RATS 1114 Company Sanitized. Does notcontain TSCACBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations__________________ DuPont-5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION Footnotes EXPLANATORY NOTES a Copulation plug observed but no litter delivered. b c NDoatalitnteort dcoellilveecrteedd,ohnodwaeyv2e1r, dimuepltaonetrartoior.n sites observed at necropsy. Notes This appendix includes only signs from rats with copulation plug observed. 1115 Company Sanitized. Does not contain TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643352^ 643343 643459 643394a 643480 643350a 643363 643397* 643421* 643420a 643419 643414e 643401 643455 643378 643447* 643478 643386 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA RIGHT FRONT LEG ALOPECIA RIGHT FRONT PAW ALOPECIA RIGHT SHOULDER SORE RIGHT SHOULDER NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 21 21 21 21 21 21 21 21 1116 Company Sanitized. Does notcontain TSCACBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643399 643334* 643464* 643369 643490 643342 643438 643445a 643418 643325 643403a 643376 643422e 643452 643475 643372 643400 643395* 643457* NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA RIGHT FRONT L E G (S ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 07 14 21 1117 Company Sanitized. Does not contain TSCACBI H90--2D45ay16G:aSvaugbechSitoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643320 6434883 643428 643439 643353 6433853 643339-b 6434733 643337-b 643416 643407-b 6433573 643331 643427 643434 643349 643454-k 643333 643460 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STAINED ABDOMEN YELLOW NO ABNORMALITIES DETECTED ALOPECIA LEFT FRONT LEG(S) STAINED PERINEUM YELLOW NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED FOUND DEAD 03/20/01 (Test Day 99) NO ABNORMALITIES DETECTED ALOPECIA LEFT FRONT LEG(S) ALOPECIA BOTH FRONT LEG(S) 00 7 14 00 22 22 07 14 21 1118 Company Sanitized. Does notcontainTSCACBI H90--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj. FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643467 643443 643417 643413 643338 643468 643440 643430a 643326 643365 643375 643328 643348a 643346 643449 643429 643424a ALOPECIA LEFT HIND QUARTERS ALOPECIA RIGHT SIDE(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STAINED PERINEUM YELLOW WET PERINEUM NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ACCIDENTALLY KILLED 03/12/01 (Test Day 91) NO ABNORMALITIES DETECTED ALOPECIA BOTH REAR LEG(S) ALOPECIA RIGHT FRONT LEG(S) TEETH CLIPPED ALOPECIA RIGHT FRONT PAW(S) DIARRHEA WET UNDERBODY STAINED FACE BROWN WEAK NO ABNORMALITIES DETECTED 14 0 0 0 21 21 21 21 21 21 21 14 21 14 0 21 21 21 21 21 1119 Company Sanitized. Does notcontain TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX X REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION 1120 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No copulation plug was observed, however, a litter was delivered. b Found dead prior to collection of Day 0 lactation clinical signs. Note This appendix includes clinical observations from lactating rats only. 1121 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING LACTATION GROUP: I.I-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643343 643459 643480 643363 643397 643421 643419 643401 643455 643378 643447 643478 643386 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO a b n o r m a l i t i e s DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 ALOPECIA LEFT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 126 21 21 1122 Company Sanitized. Does not contain TSCACBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643399 643334 643464 643369 643490 643342 643438 643418 643325 643479a 643376 643452 643475 643372 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 132 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 DISCHARGE VAGINAL OPENING RED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 ALOPECIA BOTH FRONT L E G (S ) SACRIFICED BY DESIGN TEST DAY 123 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 123 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST. DAY 122 . . 0 7 0 7 0 21 21 21 1123 Company Sanitized. Does not contain TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643400 643395 643457 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 # 1124 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643320 643428 643439 643353 643339 643337 643416 643407 643331 643427 643434 643349 643333 643460 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 120 COLORED DISCHARGE NOSE BROWN ABNORMAL GAIT OR MOBILITY HUNCHED OVER DISCHARGE VAGINAL OPENING RED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA RIGHT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA BOTH FRONT L E G (S} SACRIFICED BY DESIGN TEST DAY 120 0 21 00 07 00 00 14 21 21 21 0 21 1125 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj. FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643467 643443 643417 643413 643338 643335a 643468 643440 643326 643365 643375 643328 643449 643429-fr NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 TEETH CLIPPED ALOPECIA RIGHT FRONT L E G (S) ALOPECIA LEFT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED . SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST. DAY 125 FOUND DEAD TEST DAY 106 77 14 21 21 21 00 1126 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX Y INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN P, FEMALE RATS 1127 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN PtFEMALE RATS DuPont-5386 EXPLANATORY NOTES Footnotes: a b c d Mean cycle length was not calculable due to insufficient data. NNoo pevreidcoenitcael ionftecrovpaullcaotiuolndwbeascfaolcuunlda;teadnisminaclewnaosenvoidt penrecgenoafnct.opulation was found. Nstaotiesvtiicdaelnacneaolyfsciospsuinlacteiothnewaansimfoaulnwda, sbuptreagnnimanatldwuarisnpgrepganrtaontf.thDeaetsatrwoeurseceyxccleluedveadlufraotimon. Abbreviations: -- = No Data 1128 Company San.taed. woes no contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 643421 643397 643363 643350 643319* 643480 643394 643459 643343 643352 643386 643478 643477 643393* 643378 643455 643401 643414 643419 643420 23 22 25 27 35 24 25 21 24 22 29 : 25 23 35 27 24 23 22 25 30 22 23 24 89 71 21 20 19 21 27 24 24 17 26 22 25 26 32 24 23 65 50 64 7 23 75 68 71 75 73 59 68 78 54 67 58 65 50 56 63 13 3.80 2 27 4.00 2 12 4.00 4 4 __ a 6 6 10.50 __ c 4 4.00 3 12 4.50 5 10 5.33 1 4 4.50 3 0 4.00 1 17 4.60 8 8 4.00 4 4 4.00 2 20 4.00 __ c 11 4.25 6 17 5.00 4 9 5.00 3 18 4.00 1 20 4.00 4 13 6.50 10 % 1129 Company Sanitized. Does not contain tscacbi H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP IV-0: 25 MG/KG/DAY ANIMAL NUMBER NUMBER OP DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 643325 643418 643445 643438 643342 643490 643369 643464 643334 643399 643457 643395 643400 643372 643475 643452 643422 643376 643403 643479d 26 27 24 24 26 22 22 23 23 34 23 23 24 25 21 22 24 23 22 35 31 58 26 70 17 71 8 79 31 54 23 73 36 59 13 78 22 70 18 68 22 74 13 70 25 67 24 48 19 67 27 55 29 54 22 57 5 73 17 74 12 5.00 5 4 4.20 7 13 4.00 3 13 7.33 3 15 4.00 5 5 4.00 1 5 5.00 1 9 4.00 2 9 4.00 2 15 4.83 13 4 4.00 2 17 5.00 2 8 4.00 3 28 4.00 4 14 4.67 1 18 4.67 1 17 3.80 3 22 4.00 3 23 4.50 1 9 4.75 __ c 1130 Company Sanitized. Does notcontain TSCACBI 9H0--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VI-0: 100 MG/KG/DAY ANIMAL NUMBER 643416 643337 643473 643339 643385 643353 643439 643428 643488 643320 643460 643333 643454 643349 643434 643470e 643427 643331 643357 643407 NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 25 20 76 4 5.00 4 23 22 65 13 5.00 2 25 24 68 8 4.75 4 23 22 70 9 4.25 2 21 24 67 10 5.00 1 22 27 55 18 4.67 1 25 20 60 20 4.00 4 25 8 80 12 6.67 4 25 28 60 12 4.50 4 25 24 64 12 4.75 4 21 10 62 29 3.75 1 22 27 55 18 4.33 1 23 26 61 13 4.50 2 24 25 63 13 4.00 3 25 20 76 4 4.00 4 35 91 9 0 __ a __ c 24 8 71 21 6.00 3 22 9 77 14 4.00 1 22 32 55 14 4.00 1 23 30 65 4 5.00 2 1131 Company Sanitized. Does not contain TSCACBl H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643431* 643430 643440 643468 643335d 643338 643413 643417 643443 643467 643424 643429 643449 643346 643348 643328 643375 643365 643326 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VIII-0: 250 MG/KG/DAY NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 35 23 69 9 5.33 __ c 22 18 68 14 4.33 1 24 13 79 8 9.50 4 27 7 78 15 6.00 6 33 12 88 0 6.00 __ c 24 21 67 13 4.25 4 25 24 72 4 4.00 4 22 23 59 18 4.00 1 22 32 55 14 3.75 1 27 7 70 22 4.00 6 22 32 68 0 4.33 1 29 10 69 21 4.40 8 27 26 67 7 3.67 7 22 14 82 5 4.00 2 24 25 71 4 4.00 4 23 17 70 13 5.33 2 23 13 74 13 5.00 2 24 25 58 17 5.00 4 25 24 64 12 4.00 4 1132 Company Sanitized. Does notcontain TSCACBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX Z INDIVIDUAL ANIMACLOEHSATBRIOTAUTSICOYNCINLEPiSTFEAMGEASLEDURRAITNSG PREMATING AND % 1133 __________________ CompanySanitized. Does notcontain TSCACBi 9H0--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS EXPLANATORY NOTES Notes: TTeesstt DDaayyss 5745--7885 PCroehmabatiitnatgion period Abbreviations: DE == EDsitersutsrus XP == PNrooessatmrupsle or stage could not be defined from sample. Footnotes: a No evidence of copulation was found; animal was not pregnant. >No evidence of copulation was found; animal was pregnant. 1134 Company Sanitized. Does notcontain TSCACBI  H90--2D45ay16G:aSvaugbechSrtoundiyc.iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY TEST DAYS 66 67 DD D mE M_E_ E 68 P P D, E 69 E E D E 70 D D E 71 D. dE E 72 D P D E 7E3 E E 74 1D1 P E 75 D D E E 76 77 PP|| e !mE 78 Ei 79 E 80 81 82 83 84 85 86 87 88 3 l J?_ JL JL e p' e P D E e ee D, d d: eD D' eD e T)1 E e' d ;J L mE DEjMD DD BD D s DD_ D Dj _DJ w E D_ ' E x_ E E D, D E D E D D DD p PE PDNE [iDlvl D m|DD D DP aP D D D P_ E b so DEE _E_ E iDDDDll D m _D fDt a mnp _ Ej i1p51] B DDD D_ n m un EEEEEEE '! p E 11 ft P E D D D E e" _E_ E DD P E D . p i n a J np _E_ m PE i # H/-24-516: Subchronic Toxicity m jO-Day Gavage Study in Rats with One-Generation Reproductive Evaluations # DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP IV-0: 25 MG/KG/DAY ANIMAL 36NU4M3B3E2R5 643418 64 3445 643438 A6 4 3 3 4 2 643490 643369 643464 A6 4 3 3 3 4 643399 643457 A66 44 33 34 90 50 66 44 33 34 77 25 643452 643422 A6 4 3 3 7 6 373166 44 33 440739 iI!;!QD1OID!PD5PDdiDDDDD!4iT,iI1:|''fMDplD:IEDD5DdD''eDDD.5,lHl05DDPlDa6lDlBiD5EPDn7IDDDDD5PDEDDPD8I|EEiDDDEDD5El9l|6DDD012EDDEEEEDEPDDD2DDEEDl12I_HADDD6EDEDDDDPPDDESl2__l22_QDDDD6EPDDEDDDPDDPP113__E2JDDDDDDEEPDDDEDDEEPL1_mEt_DDEEEDeDEppDDEPEEDi__1DDD6DDEEEEDDDDPDDEDD16_1e221_DDDDE6EDDDDPED1:P171__I2i:DDDDD6DDEPPEEPdESE.8_|LAsJDDDD6DDEDEEXD2WlLD9J,1iTI1DDDE7DDEPPPDDDDPEDD1Ei01lS, 1iT3DDDDDEEE7EDDEDD2DPD1]."_D1[A3DDDDDDDDD7DDDPEEE2EEY2.SmIDDDDD7EEEPPDDDDDPpPE3' [DDDDDDDDEDEDDDDDP7DDP4.Ep!I,DDDDDDEPPPDDEPEPlfl'iKJ3333pDDD7pDEP".116]1mm~A7DD1EP71POnD7DDD8_HH_0d7D9;_132'82i01p338T1,;8PD2 83 E ;D 84 K 3 85 86 87 illlrDo 3 ili i l 88 n 11 1136 Company anitize& Oes not contain TSCA CBl H90--2D45ay16G: aSyaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VI-0: 100 MG/KG/DAY ANIMAL TEST DAYS NUMBER 643416 643337 643473 643339 643385 66 443334 3593 1 16 4 3 4 2 8 664433342808 m6 4 3 4 6 0 I I 643 3 3 3 643454 26 4 3 3 4 9 H6 4 3 4 3 4 643470 643427 643331 643357 54 55 56 a ia tp ; D D D| D1 D D. ;IPD]M 3 i!P ISn idi p e i D Dl DD D T> Id Dl [p~ Dl Pi E f Ei E E M DD D 59 DD DD DD E P D D D D 60 DD E E DP ~D| E D D D P D D 61 62 "dD"mDD DD DE XD DD DE DE mE dE D la D D Dl 63 64 D. 65 D D Id ! DD J^ DD jDDD DD DD DD 66 67 _P_J_ D DP D DD :D X D D 68 IT E DP D D 69 70 71 D D mD' D ID ED EP E D ID D ID D ID D I 72 D D D DD D DI D 7D3:E E [ RE. D D 77 78 D R . d" D' D D DP D_P] RE L - . D D DDDDP.]iEEP.iDDDll! D DD |"PD: DP DPE D \ El E D DEE D K E O E I mE DDDP 79 E 80 ][ 81 E Di DD: D D P DEP E DD D D iD D Dm i 82 E 83 E 84 85 1 EE 86 87 i EE 88 E 1137 SsBlMzed, Does noieortalmTSCA CBf # /' # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _________________ # DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VIII-0 : 250 MG/KG/DAY ANIMAL TEST DAYS | NUMBER 54 55 56 57 58 60 61 62 63 64 65 66 67 \ 6 8 69 70 71 72 74 75 76 77 178 79 80 81 82 83 84 85186187 88 643431 P _ E _ 0 :D; D 1 D D D U a , P D D | D D D P E D D P E E D A A A I g i l P E A p r a a643430 D E E D D Dig d d D D D O D D P, D dTd 643440 D 1 1 P D D D d d d |d |d D D D D, P E D D ! A A pkap dJd643468 D b D D DH d d d DD D D D D D D S p ila p n a a643335 m D B3| D D D D | d P d x [p ] d D D l a p 11 D D d : D X d :H A g 1 m H 11 Pj: B ! 643338 E D I d D _P E D D D r a p DD P E DDDX DDD p i'sMipj643413 m 0 D D D E D d d d p |p |p i D D P E 11 D D E w D D 643417 D D E D d |p M D p p ^ a D D D M D D D P 643443 E E E D D P D d pa E 9 d d |d ^3 D D P E D D D E pli643467 P 3 d d D P D D g d d o d d 11 D P E [d D D P DA a il643424 D DID E E D D E E D d J d m D D H E E D D P pi [F pi PI B lai643429 n i D jDj D D 0 D | d E I d "d ] d P D D D PE DD P E [x p p643449 E 0 D D E D D D 0 D D l D d D D D E 3 d D P DD PE A ili PS643346 111 Dj D P D D d d d i dI d d : E D D E D X SBJ A A 1 S D i i643348 [p D; E X DIpDDDp D P E D D DD d| eH643328 D D p i E D D D D d D P l p P p P E DEDDP dJ A P D ~bla643375 li! JE_ D D D D D | a D D D P D D P; _p_ A i643365 g A A S JP643326 gD D D X P E M D Dha^al P, D ~d Tm D D D E D "d" P p D JD_D Vaj D HDD D0 D D P D E _D_ n D 1 1138 Company-Sanitized. Does not contain TSCA CBI H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX AA REPRODUCTIVE TOXICOLOGY INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pt MALE RATS % " 39 TSCACBICom pany SanHtoed. Does not contain H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pa MALE RATS GROUP 1-0 0 MG/KG/DAY Animal Percent Number____Motile 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 93 90 95 99 96 91 86 94 95 94 GROUP V-0 100 MG/KG/DAY Animal Number Percent Motile 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 96 91 96 84 93 95 96 92 98 92 GROUP III-O 25 MG/KG/DAY Animal Number Percent Motile 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 89 92 78 98 95 92 91 93 96 98 . GROUP VII-0 250 MG/KG/DAY Animal Number Percent Motile 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 80 89 97 95 95 92 81 89 97 88 1140 Company Sanitized. Does not contain TSCA CBI 9H0--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX BB INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P, MALE RATS 1141 Company Saniliaed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Px MALE RATS GROUP 1-0: 0 MG/KG/DAY Animal Number 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 Total Normal 199 200 195 197 199 198 197 197 196 198 Tail Abnormal 1 0 0 0 1 0 1 0 2 0 Head Abnormal 0 0 5 3 0 2 2 3 2 2 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 99.5 100.0 97.5 98.5 99.5 99.0 98.5 98.5 98.0 99.0 GROUP III-O: 25 MG/KG/DAY Animal Number 643287 6431^8 643230 643170 643144 643277 643214 643261 643166 643153 Total Tail Normal Abnormal 199 . 199 198 198 199 199 192 200 198 197 0 0 0 0 0 1 2 0 0 1 Head Abnormal 1 1 2 2 1 0 6 0 2 2 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 99.5 99.5 99.0 99.0 99.5 99.5 96.0 100.0 99.0 98.5 1142 Company Sanitized. Does notcontain TSCACBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Px MALE RATS GROUP V-0: 100 MG/KG/DAY Animal Number 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 Total Normal 195 198 198 200 199 199 199 198 198 199 Tail Abnormal 0 1 1 0 0 0 0 1 1 0 Head Abnormal 5 1 1 0 1 1 1 1 1 1 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 97.5 99.0 99.0 100.0 99.5 99.5 99.5 99.0 99.0 99.5 GROUP VII-0 : 250 MG/KG/DAY Animal Number 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 Total Normal 196 193 199 200 197 200 197 198 200 197 Tail Abnormal 2 6 1 0 0 0 0 0 0 0 Head Abnormal 2 1 0 0 3 0 3 2 0 3 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 98.0 96.5 99.5 100.0 98.5 100.0 98.5 99.0 100.0 98.5 1143 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX CC INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN Pj MALE RATS 1144 Company Sanitized. Does notcontain TSCA CBl H90--2D45ay16G:aSvaugbechSrtoundiyciTnoRxaictsitywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Px MALE RATS GROUP 1-0: 0 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 311.0 299.3 256.0 254.9 311.0 341.4 332.0 332.0 282.9 266.6 1067.8 1249.0 758.6 858.1 1002.4 1154.4 1195.5 1216.1 869.1 938.2 -0: 25 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 274.2 229.1 272.4 346.0 280.6 225.6 280.6 254.9 337.9 296.9 1191.1 850.8 906.7 1045.1 1131.3 836.3 934.9 899.9 1238.4 948.4 Testicular Spermatids Per testis Per g testis 109.9 128.0 147.9 131.0 144.4 151.4 146.7 103.5 118.7 119.3 69.0 81.3 90.0 84.2 86.4 103.0 100.5 65.4 75.1 89.8 Testicular Spermatids Per testis Per g testis 114.0 112.2 118.7 136.8 107.0 152.6 122.8 124.5 114.6 114.6 94.8 66.5 74.0 79.8 88.4 110.5 79.6 86.2 81.4 83.3 1145 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evalimrinnc DuPont-5386 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Px MALE RATS GROUP V-0: 100 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 339.0 285.3 301.6 240.8 261.9 321.5 187.1 249.0 281.7 312.1 GROUP VII-0: 250 MG/KG/DAY 1239.5 945.8 970.4 723.6 879.6 1054.7 690.2 884.2 910.9 1198.6 Testicular Spermatids Per testis Per g testis 154.3 158.4 166.0 135.0 168.4 154.9 163.7 162.5 166.6 169.5 106.3 101.0 103.1 81.1 98.0 91.4 108.3 102.6 106.1 112.8 Animal ____ Epididymal Sperm________ Testicular Spermatids Number Per cauda Per g cauda Per testis Per g ___________ __________________ testis 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 368.3 282.9 327.3 328.5 426.7 244.3 231.5 318.0 245.5 218.6 1280.8 894.7 884.9 977.7 1116.7 906.9 742.6 897.5 859.3 895.6 144.4 119.8 133.9 122.2 161.3 154.3 166.0 169.5 151.4 142.6 96.1 94.0 79.1 81.5 101.8 99.4 110.8 87.3 91.3 90.7 1146 Company Sanitized. Does not contain TSCA CB1 9H0--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluating DuPont-5386 APPENDIX DD REPRODUCTIVE TOXICOLOGY INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION 1147 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyciTnoRxaictsitywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION EXPLANATORY NOTES Notes: Column labeled "Plug Observed" + indicates that a copulatory plug was observed - indicates that no copulatory plug was observed Column labeled "Litter Produced" + indicates that a litter was produced - indicates that no litter was produced Footnotes: a No litter delivered, however, implantation sites were observed at necropsy. b uNnokncoopwunl.ation plug was observed, however, a litter was delivered. Gestation length c Found dead on Day 22G (Test Day 99). d e Accidentally killed on Day 14G (Test Day 91). Found dead on Lactation Day 0 (Test Day 106). 1148 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-GenerationReproductive Evaluations DuPont-5386 FEMALE ANIMAL# 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414a 643401 643455 643378 643393 643447 643478 643386 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: 11-0,1-0 DOSE: 0 MG/KG/DAY MALE #1 ANIMAL# 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643254 PLUG OBSERVED + + + + + - + + + + + + + + + + + + + MALE #2 ANIMAL# PLUG LITTER GESTATION OBSERVED PRODUCED LENGTH(days) + 23 + 23 + 23 + 22 + 22 + 22 + 22 + 22 + 22 + 23 + 22 + 22 + 22 % ' 1149 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 FEMALE ANIMAL# 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479* 643403 643376 643422a 643452 643475 643372 643400 643395 643457 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: IV-0,III-0 DOSE: 25 MG/KG/DAY MALE #1 ANIMAL# 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 PLUG OBSERVED + + + + + + + + + + + + + + + '+ + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + + + + + + + + + + + + + + GESTATION LENGTH(days) 23 22 23 22 22 22 22 22 22 -- 21 23 23 22 22 22 22 1150 Company Sanitized. Does not cornato TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 FEMALE ANIMAL# 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454e 643333 643460 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VI-0,V-0 DOSE: 100 MG/KG/DAY MALE #1 ANIMAL# 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 PLUG OBSERVED + + + + + + + + + + + + + + + '+ + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + + + + + + + + + + + GESTATION LENGTH(days) 22 22 22 23 22 22 22 22 23 23 22 22 23 23 % 1151 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 FEMALE ANIMAL# 643467 643443 643417 643413 643338 643335* 643468 643440 643430 643431 643326 643365 643375 643328 643348 643346d 643449 643429e 643424 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VIII-0,VII-0 DOSE: 250 MG/KG/DAY MALE #1 ANIMAL# 643289 643171 643158 643249 643161 643274 643248 643285 643278 643299 643192 643222 643160 643191 643203 643282 643302 643317 643281 PLUG OBSERVED + + + + + - + + + - + + + + + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + + + + + - - + + + + - + + - GESTATION LENGTH(days) 23 22 22 22 22 -23 22 --22 22 23 23 --22 23 -- 1152 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX EE REPRODUCTIVE TOXICOLOGY INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY m 1153 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations____________________DuPont-5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY EXPLANATORY NOTES Footnotes: a No implantation efficiency can be calculated. b No litter produced; no implantation efficiency calculated. c Found dead Day 22G (Test Day 99); the uterus contained 17 fetuses. d Accidentally killed Day 14G (Test Day 91); the uterus contained 12 fetuses. e Found dead Lactation Day 0 (Test Day 106). Abbreviations: -- No data % 1154 Company Sanitized. Does not contain TSCACffl H90--2D45ay16G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: II-0 DOSE: 0 MG/KG/DAY Animal Number Pups Bom Number of Implantation Sites Implantation Efficiency 643343 643459 643480 643363 643397 643421 643419 643414^ 643401 643455 643378 643447 643478 643386 12 15 15 17 16 12 16 0 15 16 8 19 15 15 10 16 15 18 17 13 15 2 16 16 8 19 15 16 __ a 93.8 100.0 94.4 94.1 92.3 __ a -- 93.8 100.0 100.0 100.0 100.0 93.8 55 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: IV-0 DOSE: 25 MG/KG/DAY Animal Number Pups Bora Number of Implantation Sites Implantation Efficiency 643399 643334 643464 643369 643490 . 643342 643438 643418 643325 643479 643376 643422*' 643452 643475 643372 643400 643395 643457 14 15 14 18 14 16 14 15 15 7 15 0 12 2 17 15 8 16 17 16 14 14 14 16 17 15 16 9 16 2 15 4 18 15 8 16 82.4 93.8 100.0 __ a 100.0 100.0 82.4 100.0 93.8 77.8 93.8 -- 80.0 50.0 94.4 100.0 100.0 100.0 1156 Company Sanitized. Does not contain TSCA H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 # INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VI-0 DOSE: 100 MG/KG/DAY Animal Number Pups Bom Number of Implantation Sites Implantation Efficiency 643320 643428 643439 643353 643339 643337 643416 643407 643331 643427 643434 643349 643454e 643333 643460 6 14 14 9 15 15 6 16 9 14 16 18 -- 7 14 15 16 16 11 16 . 17 8 14 12 15 14 18 17 9 14 40.0 87.5 87.5 81.8 93.8. 88.2 75.0 __ a 75.0 93.3 __ a 100.0 -- 77.8 100.0 1157 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VIII-0 DOSE: 250 MG/KG/DAY Animal Number Pups Bom Number of Implantation Sites Implantation Efficiency 643467 643443 643417 643413 643338 643335 643468 643440 643326 643365 643375 643328 643346^ 643449 643429e 13 12 10 12 14 14 14 18 14 9 5 11 -- 17 16 12 11 13 12 16 16 18 18 16 8 14 12 12 17 15 __ a __ a 76.9 100.0 87.5 87.5 77.8 100.0 87.5 __ a 35.7 91.7 -- 100.0 __ a % . : 58 Company Sanitized. Does not contain TSCA CSi H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX FF REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP SURVIVAL: F, GENERATION 1159 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 9 REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP SURVIVAL: Fj GENERATION EXPLANATORY NOTES Footnotes: a No litter delivered. b c AFocucniddednetaaldlyteksitlldeadyte9s9t (dDayay9122(GD)a.y 14G); no litter was delivered. d e Found dead test day 106 (Lactation Day 0); data excluded from statistical analysis. Number bom includes 13 unsexable fetuses. 1160 Company Sanitized. Does not contain TSCA CBl m H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643352s 643343 643459 643394s 643480 643319s 643350s 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 BORN _ 12 15 - .15 - - 17 16 12 16 15 16 8 19 15 15 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 *- -- 12 12 8 8 15 15 88 -- -- 15 15 8 8 - --- - --- 17 17 8 8 16 16 8 8 12 12 8 8 -- -- 16 16 8 8 - - - - 15 15 8 8 15 15 8 8 88 88 -- -- 19 19 8 8 15 15 88 15 15 8 8 DAY 14 8 8 8 8 8 8 8 8 8 8 8 8 8 C O C O C O > 0 0 I CO CO CO I CO CO CO DuPont-5386 % 1161 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643319a 6 43350a 643363 643397 643421 643420a 643419 643414a 643401 643455 643378 643393a 643447 643478 643386 BORN _ 6 12 - 6 7 8 6 - 11 - 12 10 5 - 12 8 10 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 _ 6 12 - 6 7 8 6 - 11 - 12 9 5 - 12 8 10 _ 6 12 - 6 7 8 6 - 11 - 12 9 5 - 12 8 10 -- 44 55 -- 44 -- - 44 44 44 -44 -55 44 55 -44 44 44 DAY : - 4 5 4 4 4 4 4 5 4 5 4 4 4 DuPont-5386 1162 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643352s 643343 643459 543394a 643480 643319s 643350s 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 BORN - 6 3 9 - 10 8 6 5 3 6 3 7 7 5 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 -- - - - 6 6444 3 3 3 33 -- - - - . 99444 -- - -- - --1 0 10 4 4 4 8 8444 6 64 44 -- - - 5 54 44 -' - - - 333 33 6 64 44 33 3 33 -- - - 774 44 7 74 44 55 4 44 ' : U63 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643352* 643343 643459 643394* 643480 643319* 643350* 643363 643397 643421 643420* 643419 643414* 643401 643455 643378 643393* 643447 643478 643386 INDIVIDUAL PUP SURVIVAL: F! GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY _ 0.50 0.80 - 0.40 - - 0.41 0.50 0.50 - 0.69 - 0.80 0.63 0.63 0.63 0.53 0.67 - 1 0 0 .0 1 0 0 .0 - 1 0 0 .0 -' 1 0 0 .0 1 0 0 .0 1 0 0 .0 - 1 0 0 .0 - 1 0 0 .0 93.8 1 0 0 .0 - 1 0 0 .0 1 0 0 .0 1 0 0 .0 . - 1 0 0 .0 1 0 0 .0 - 1 0 0 .0 - 1 0 0 .0 1 0 0 .0 1 0 0 .0 - 1 0 0 .0 - 1 0 0 .0 1 0 0 .0 1 0 0 .0 - 1 0 0 .0 1 0 0 .0 1 0 0 .0 DuPont-5386 LACTATION INDEX - 100 .0 100 .0 - 100 .0 - 1 0 0 .0 100 .0 100 .0 - 100 .0 - 100 .0 1 0 0 .0 1 0 0 .0 - 1 0 0 .0 1 0 0 .0 1 0 0 .0 % H64 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643352s 643343 643459 643394s 643480 643319s 643350a 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 - 100.0 - 100.0 100.0 100.0 100.0 - ' 100.0 90.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 - - 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-5386 1165 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643352^ 643343 643459 643394a 643480 643319s 643350s 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 -" 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 - 100.0 - - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 DuPont-5386 # 1166 Company Sanitized. Does notcontain TSCACflf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445s 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 BORN 14 15 14 18 14 16 14 15 15 7 15 - 12 2 17 15 8 16 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 14 14 8 8 8 8 15 15 8 8 8 8 14 14 8 8 8 8 18 18 8 8 8 8 14 14 8 8 8 8 16 16 8 8 8 8 14 13 8 8 8 8 ----- - 15 13 8 8 8 8 15 15 8 8 8 8 7 7 777 7 ----- - 14 14 8 6 8 8 ----- - 12 12 8 8 8 8 2 2 222 2 17 17 8 8 8 8 14 12 888 8 88888 8 16 15 8 8 8 8 % 1167 Company Sanitized. Does notcontain TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445s 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 BORN 6 10 5 7 10 8 6 - 8 11 1 - 11 - 7 0 10 9 4 10 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 6 644 10 10 4 4 5 54 4 7 744 10 10 4 4 8 844 6 644 --- - 8 744 11 11 4 4 1 11 1 - -- - 10 10 4 4 -- _ - 7 744 0000 10 10 4 4 8 844 4 444 10 10 4 4 DAY 14 DAY 21 44 44 44 44 44 44 44 -44 44 11 -- 44 -44 00 44 44 44 44 1168 Company Sanitized. Does not contain TSCACBl H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479 643403a 643376 643422a 643452 643475 643372 643400 643395 643457 BORN 8 5 9 11 4 8 8 - 7 4 6 - 4 - 5 2 7 6 4 6 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OP FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 88 55 99 11 11 44 88 87 -- 76 44 6 - 6 - 44 -- 55 22 77 64 44 65 44 44 44 44 44 44 44 -- 44 44 66 -- 44 -- 44 22 44 4 ' 4 44 44 DAY 14 DAY 21 44 44 44 44 44 44 44 - 4 4 6 ^ - 44 - 4 2 42 44 44 44 44 1169 Company Sanitized. Does not contain TSCACBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643399 643334 643464 643369. 643490 643342 643438 643445s 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.43 0.67 0.36 0.39 0.71 0.50 0.43 0.53 0.73 0.14 0.73 0.58 0.00 0.59 0.60 0.50 0.63 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 100.0 100.0 100.0 93.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.9 86.7 100.0 100.0 100.0 100.0 100.0 100.0 85.7 100.0 93.8 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1 0 0 .0 100.0 1170 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445s 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY % BORN ALIVE 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.9 100.0 100.0 88.9 100.0 100.0 NUMBER OF MALE PUPS 0-4 DAY VIA LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-5386 1171 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 INDIVIDUAL PUP SURVIVAL: F 1 GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY % BORN ALIVE 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 NUMBER OF FEMALE PUPS LACTATION 0-4 DAY VIABILITY INDEX 100.0 100.0 100.0 100.0 100.0 100.0 87.5 - 85.7 100.0 100.0 100.0 100.0 100.0 100.0 66.7 100.0 83.3 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-5386 1172 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470a 643434 643349 643454* 643333 643460 BORN 6 - 14 14 9 - 15 - 15 6 16 - 9 14 - 16 18 - 7 14 INDIVIDUAL PUP SURVIVAL: Fj GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 44444 4 - -- - - - 14 14 8 8 8 8 10 10 8 8 8 8 99888 8 - - - - -' - 15 15 8 8 8 8 - -- - - - 15 15 8 8 8 8 65555 5 16 0 0 0 0 0 - -- - - - 00000 0 14 14 8 8 8 8 -- - - - - 16 16 8 8 8 8 18 17 8 8 8 8 . -- - - - - 77777 7 14 14 8 8 8 8 1173 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470a 643434 643349 643454* 643333e 643460 BORN 3 7 9 5 6 8 5 7 4 5 6 7 3e 7 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OP MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 2222 - - -7 744 7755 5544 ---6644 ---8844 54 44 7 000 ---00 00 5544 -- -6644 7644 ---- 3e 3 3 3 7744 DAY 14 2 4 5 4 4 4 4 0 0 4 4 4 3 4 tC. o I ^ I U1 DuPont-5386 % : F74 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF FEMALE PUPS ANIMAL NUMBER BORN BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 643320 3 2 2 2 2 2 643488a - - - - - " 643428 7 7 7 4 4 4 643439 5 3 3 3 3 3 643353 643385s 4 - 4 - 4 - 4 - 4 - 4 _ 643339 9 9 9 4 4 4 643473s - - - - - " 643337 7 7 7 4 4 4 643416 1 1 1 1 1 1 643407 9 9 0 0 0 0 643357s - - - - - " 643331 5 0 0 0 0 0 643427 9 9 9 4 4 4 643470s - - - - - " 643434 10 10 10 4 4 4 643349 11 11 11 4 4 4 643454* ' - - - - - - 643333e 4e 4e 4 643460 7 7 7 4 4 4 4 4 4 % i i * f i <* h o i o ** DuPont-5386 ' " U75 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643320 643488s 643428 643439 643353 643385s 643339 643473s 643337 643416 643407 643357s 643331 643427 643470s 643434 643349 643454-6 643333 643460 INDIVIDUAL PUP SURVIVAL: F* GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.50 - 0.50 0.64 0.56 - 0.40 - 0.53 0.83 0.44 0.44 0.36 - 0.38 0.39 - 0.43 0.50 66.7 100.0 71.4 100.0 100.0 -' 100.0 100.0 100.0 0.0 100.0 100.0 100.0 -100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 83.3 0.0 100.0 100.0 94.4 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1176 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL ' NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470a 643434 643349 643454b 643333 643460 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 66.7 - 100.0 77.8 100.0 - 100.0 - 100.0 100.0 100.0 - 0.0 100.0 - 100.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 80.0 0.0 - 100.0 - 100.0 85.7 - 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 - 100.0 - 100.0 100.0 - 100.0 100.0 ' DuPont-5386 1177 Company Sanitized. Does not contain TSCA CSl H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470s 643434 643349 643454* 643333 643460 INDIVIDUAL PUP SURVIVAL: Ft GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY % BORN ALIVE NUMBER OF FEMALE PUPS LACTATION 0-4 DAY VIABILITY INDEX 66.7 - 100.0 60.0 100.0 - 100.0 - 100.0 100.0 100.0 0.0 100.0 - 100.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 0.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-5386 1178 Company Sanitized. Does not contain TSCA CBl % H90--2D4a5y16G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER BORN 643467 . 13 643443 12 643417 10 643413 . 12 643338 14 643335 14 643468 14 643440 18 643430a - 643431a - 643326 14 643365 9 643375 5 643328 11 643348a - 643346c - 643449 17 643429d'e 16 643424a - INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 13 13 8 8 12 12 8 8 10 10 8 8 12 12 8 8 14 14 8 8 14 14 88 14 14 8 8 18 18 8 8 ---- -- -- 13 12 8 8 88 88 11 10 11 8 8 8 ---- ---- 17 17 8 8 0--- ---- DAY 14 DAY 21 88 88 88 88 88 88 88 88 --88 88 00 88 --- -" 88 --- % : 1179 Company Sanitized. Does not contain TSCA CBI 9H0--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduc,tive Evaluations DuPont-5386 ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 643326 643365 643375 643328 643348a 643346e 643449 643429<d 643424a BORN 8 7 6 7 8 7 9 9 8 4 3 6 10 0 - INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 88 77 66 77 88 77 99 99 --- 76 33 .0 0 64 --- 10 10 0-- 4 4 4 4. 4 4 4 4 4 3 0 4 4 - 4 4 4 4 4 4 4 4 4 3 0 4 4 - DAY 14 DAY 21 44 44 44 44 44 44 44 44 --44 33 00 44 --44 --- 1180 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 643326 643365 643375 643328 643348a 643346c 643449 643429d 643424a BORN 5 5 4 5 6 7 5 9 - - 6 5 2 5 - - 7 3 - INDIVIDUAL PUP SURVVAL: Fx GENERATION GROUP : VIII-0 DOSE: 250 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY : 55444 4 5 5444 4 44444 4 5 54444 6 6444 4 7 7444 4 55444 4 9 9444 4 -- - - - - -- - - - 6 6444 4 5- 5 5 5 5 5 1 1 100 0 54444 4 - - - -- - - ---- " 7 7444 4 0 -- - - - - -- - 1181 Company Sanitized. Does not contain TSCA CB) H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431s 643326 643365 643375 643328 643348s 643346e 643449 643429d 643424s INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.62 0.58 0.60 0.58 0.57 0.50 0.64 0.50 - - 0.57 0.44 0.60 0.55 - - 0.59 0.00 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - - 92.9 88.9 20.0 100.0 - - 100.0 0.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - - 92.3 100.0 100.0 72.7 - 100.0 - - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0.0 100.0 100.0 - 1182 Company Sanitized. Does not contain TSCACBI H90--2D4a5y16G:avSaugbechSrtoundiyciTnoRxiactsitywith One-Generation Reproductive Evaluations ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430s 643431s 643326 643365 643375 643328 643348s 643346e 643449 643429*3 643424s INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS LACTATION 0-4 DAY VIABILITY INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - - 87.5 75.0 0.0 .. 100.0 - - 100.0 - - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - - 85.7 100.0 - 66.7 - - 100.0 - - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - - 100.0 100.0 - 100.0 - 100.0 - - DuPont-5386 1183 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations ANIMAL NUMBER S43467 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 643326 643365 643375 643328 643348a 643346e 643449 643429d 643424a INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY % BORN ALIVE NUMBER OF FEMALE PUPS LACTATION 0-4 DAY VIABILITY INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - - 100.0 100.0 50.0 . 100.0 - - 100.0 0.0 - 100.0 100.0 100.0 100.0. 100.0 100.0 100.0 100.0 - - 100.0 100.0 100.0 80.0 - - 100.0 - - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - - 100.0 100.0 0.0 100.0 - - 100.0 - - DuPont-5386 1184 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G:avSaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX GG REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP WEIGHTS: F, GENERATION H85 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP WEIGHTS: Fi GENERATION DuPont-5386 EXPLANATORY NOTES Footnotes: a b NTwoolitptuepr sdewlievreeremdi.ssexed; data excluded from male and female mean pup weights, c One pup was missexed; data excluded from male and female mean pup weights. d /e No male pups bom. NFooulnivdedpeuadpsDaatybi2r2thG. (Test Day 99). g h NReocmoradlienpgueprsrobro, mdataalievxec.luded. i j /k AFocucniddednetaaldlyLkaicllteadtioDnaDy a1y4G0 ((TTeessttDDaayy 19016).). NNoo lliivvee ppuuppss oonn LLaaccttaattiioonn DDaayy 47.. 1186 ' " "P " '' no.co,,,a,,, TSCA H90--2D4a5y16G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations____________________DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: II-0 Dose: 0 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 li 12 643352s 643343 643459 643394s 7.90 7.40 8.20 7.10 7.50 6.90 8.30 8.40 7.60 7.00 7.20 7.50 7.40 7.00 8.00 7.30 7.40 8.40 7.70 7.40 7.70 8.10 8.20 8.30 8.70 8.10 8.10 643480 643319s 6.50 8.50 8.00 7.40 8.00 7.90 7.20 8.40 7.40 8.10 7.30 7.90 7.80 7.90 7.70 643350s 643363 643397 643421 6.70 6.60 7.10 6.50 7.00 6.70 7.10 . 6.20 6.20 6.20 7.20 7.30 6.70 7.20 6.70 5.90 6.50 6.30 6.80 6.40 7.50 6.90 6.30 6.10 6.40 6.30 6.30 6.10 6.60 6.20 6.40 6.00 7.00 6.30 6.70 6.60 6.60 6.20 7.00 5.60 6.40 7.10 6.50 oo VO 6.20 ___________________________________________________________________1__1_8__7 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: II-0 Dose: 0 mg/kg/day Animal Pup Number Sex 1 2 3 4 5 6 7 8 9 10 11 12 643420a 643419 643414a 7.50 7.20 7.30 6.90 7.00 7.10 6.60 6.00 5.60 6.90 6.40 5.60 6.50 6.50 6.00 6.00 643401 643455 643378 643393a 6.10 5.30 7.00 6.40 8.70 8.10 6.20 5.80 6.50 5.90 9.20 6.60 6.20 5.60 6.60 6.30 7.90 7.90 6.30 6.90 6.50 7.90 6.10 6.60 6.70 8.40 6.90 7.10 5.90 6.00 7.00 6.20 7.20 6.40 6.90 5.40 6.10 5.90 643447 643478 643386 6.60 6.20 6.00 5.70 6.40 5.90 6.30 6.60 7.20 6.00 6.30 6.20 6.20 6.20 6.50 6.40 6.30 5.70 6.50 6.40 6.60 6.50 6.30 6.30 6.70 6.40 6.50 5.40 6.40 6.00 7.00 6.60 6.20 6.40 6.70 7.20 6.50 6.80 5.80 6.10 6.50 5.60 7.00 6.60 6.40 5.50 6.30 7.10 6.50 1188 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams) : F]_ Generation Lactation Day 0 Group: IV-0 Dose: 25 mg/kg/day Animal Number 643399* 643334 643464 643369 643490e 643342 643438 643445a Pup Sex 1 7.30 7.50 6.30 6.30 8.10 6.90 6.50 6.00 7.00 6.60 7.60 6.20 6.20 6.00 2 8.10 7.40 7.10 6.40 7.50 7.40 6.90 5.70 6.90 6.40 7.20 6.90 6.30 6.30 3 8.00 7.50 6.20 6.20 7.40 6.90 6.80 6.00 6.60 5.70 7.40 7.30 5.80 5.90 4 7.60 8.10 7.30 6.40 8.20 7.20 6.10 6.50 6.40 6.40 6.00 6.30 5.80 6.10 Pup Number 567 7.50 6.60 6.20 8.20 7.60 6.50 6.20 6.90 6.20 6.50 5.90 6.00 5.40 7.60 6.60 6.90 7.00 5.80 6.80 6.90 6.70 6.00 5.60 7.80 7.00 7.20 6.80 6.10 6.60 6.90 6.60 6.10 8 7.50 6.40 7.50 6.20 6.70 6.90 7.10 6.40 9 7.00 7.00 6.80 5.10 6.00 10 7.00 6.00 6.00 11 5.60 643418 643325 6.80 7.00 7.20 6.80 6.80 6.10 6.60 6.80 6.30 6.60 7.50 5.80 4.30 6.60 7.10 7.20 6.90 6.30 7.10 6.70 6.00 6.90 6.80 6.40 7.00 6.90 7.50 6.90 6.70 7.30 1189 Company Sanitized. Does not oontaln TSCA CBl H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: IV-0 Dose : 25 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 643479 643403a 8.30 7.00 7.50 7.70 7.60 7.20 7.20 643376 643422a 6.90 6.70 7.40 6.50 7.40 6.60 7.40 6.80 6.90 7.10 6.00 6.50 6.70 6.90 643452 643475d 643372 643400 643395e 643457 7.50 7.30 7.00 7.30 7.90 7.80 6.60 6.70 7.50 6.50 7.10 6.50 7.40 7.60 6.60 5.60 5.90 7.50 6.40 6.30 6.40 7.00 6.90 7.00 6.00 5.40 6.30 6.50 6.00 6.00 6.50 5.80 6.00 5.40 6.10 6.60 6.40 6.20 7.00 6.20 5.50 5.60 6.90 6.00 5.80 7.30 6.60 5.90 4.10 6.20 6.10 6.00 7.10 7.10 5.90 5.10 5.90 5.50 7.50 6.90 5.50 5.80 6.00 5.70 5.90 6.70 6.50 7.20 6.90 1190 CompanySanitized. Does notcontain TSCA cbI H90--2D45ay16G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: VI-0 Dose: 100 mg/kg/day DuPont-5386 Animal Number 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 Pup Number Pup Sex 1 2 3 4 5 6 7 8 9 10 11 7.20 8.00 7.00 7.30 6.40 6.70 6.70 7.00 6.00 6.50 6.40 6.00 6.00 6.70 6.40 7.20 6.80 6.80 6.80 7.00 6.10 5.70 6.40 6.90 6.80 6.70 5.50 5.30 9.10 7.50 8.90 8.30 8.30 7.50 8.40 7.40 7.10 7.40 6.80 6.50 6.30 6.20 6.70 6.90 6.50 6.30 6.70 6.40 6.20 6.20 6.50 6.40 6.20 6.60 6.80 6.40 7.20 6.60 7.20 6.50 5.50 6.40 6.50 6.50 6.10 5.20 7.00 6.20 7.10 7.60 7.00 6.00 1191 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: VI-0 Dose: 100 mg/kg/day A.ni,mal, Number 643407 643357s P_up Sex 1 5.70 5.00 2 5.30 4.50 3 6.50 5.40 4 5.70 4.90 --Pupc-N-u-m-b-e-r 56 7 6.30 5.70 5.70 5.20 5.20 6.00 8 6.10 9 5.40 10 11 643331e 643427 643470s 7.70 7.10 7.10 6.70 7.30 6.80 6.70 6.70 7.80 7.00 7.00 7.10 7.10 7.10 643434 643349 643454f 6.70 5.50 6.50 6.20 5.70 6.00 5.90 6.10 6.50 5.50 6.20 6.10 6.50 6.20 6.30 6.00 5.60 5.70 6.40 5.60 6.50 6.20 6.30 6.70 6.70 6.30 6.00 6.50 5.60 5.80 6.20 5.90 6.40 6.00 6433339 643460 8.20 8.20 7.60 8.70 8.20 8.20 7.30 7.60 7.50 7.20 7.70 7.30 7.70 7.10 % U92 Company Sanitized. Does not contain TSCA CBI 9H0--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: VIII-0 Dose: 250 mg/kg/day Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 643430a Pup Sex 1 7.20 6.90 7.00 6.80 6.30 7.50 6.80 5.30 6.80 6.60 6.90 6.00 7.80 7.50 6.30 6.00 2 6.60 6.90 6.20 6.60 6.10 5.40 7.00 6.40 6.30 5.50 6.80 6.10 7.50 6.80 6.60 6.10 3 7.00 6.80 7.20 6.70 8.00 5.70 6.10 6.70 6.90 6.20 6.30 6.50 7.80 7.60 6.40 6.10 4 7.30 6.30 7.20 6.00 8.10 7.40 7.20 6.80 6.90 6.80 7.30 6.40 7.80 6.50 6.30 5.80 Pur jtorib 56 7.40 7.00 6.40 6.70 5.90 7.10 7.10 6.00 7.30 5.90 6.60 5.70 6.60 5.90 6.30 7.50 6.30 5.80 6.70 7.40 6.80 6.50 5.40 7.60 6.80 5.60 7 7.10 7.10 5.30 6.60 6.80 5.90 6.80 6.10 6.50 8 7.50 6.80 7.10 7.00 6.60 9 7.60 6.10 5.60 643431a 1193 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 0 Group: VIII-0 Dose: 250 mg/kg/day Animal Pup Number Sex 1 643326 643365 643375* 643328 643348a 5.70 6.30 6.90 7.00 5.30 5.80 5.30 2 6.60 6.50 7.60 6.50 5.30 5.60 3 6.20 6.10 7.90 7.00 6.00 5.50 4 6.90 5.50 7.20 4.90 5.20 Pup Number 56 6.50 6.50 6.30 6.00 7.50 5.20 5.50 5.00 7 6.20 643346-* 643449 6434293 6.40 6.80 6.20 6.70 6.80 6.10 5.70 5.70 5.70 6.20 5.90 6.10 5.60 6.20 643424a DuPont-5386 1194 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: II-0 Dose: 0 mg/kg/day DuPont-5386 Animal Pup Pup Number -- ------ Number Sex 1 2 3 4 5 6 7 8 9 643352s 10 11 12 ' 643343 643459 643394s 12.10 13.00 12.70 12.30 12.20 12.60 12.10 11.90 12.00 12.10 11.10 12.10 11.10 12.30 10.90 13.80 13.50 14.20 12.10 13.00 12.70 13.80 13.60 13.30 12.30 10.10 13.20 643480 643319s 14.60 14.20 13.30 11.70 13.90 12.90 13.40 14.30 12.70 12.50 13.20 12.30 12.20 12.40 12.40 643350s 643363 643397 643421 10.20 10.90 10.20 11.10 11.40 12.70 10.70 10.90 10.40 10.30 9.50 10.40 10.40 11.00 9.90 10.60 12.00 11.60 12.80 11.90 11.70 10.40 11.90 9.20 10.90 11.50 11.30 11.40 10.50 9.70 10.80 11.20 9.20 11.20 8.60 9.80 11.60 9.10 9.90 10.90 10.20 10.20 10.10 9.20 % 1195 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): F* Gnration Lactation Day 4 Preculling Group : II--0 Dose : 0 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 11 12 643420s 643419 643414s 12.70 12.50 11.60 9.70 10.60 12.80 10.60 9.80 12.10 10.80 9.90 11.50 11.40 11.10 11.20 9.80 643401 643455 643378 643393s 643447 643478 643386 10.10 10.30 10.00 11.00 10.10 9.70 9.80 10.00 9.60 10.20 9.00 9.10 8.40 10.10 9.80 10.50 10.90 11.50 11.30 11.60 10.60 10.30 9.30 10.30 9.70 9.70 10.60 10.30 14.10 15.50 13.40 16.60 14.70 15.50 12.80 15.70 10.70 9.70 10.70 10.,80 9.90 9.60 9.50 9.70 6.30 11.00 9.90 9.50 10.80 9.80 9.40 9.90 10.00 9.80 11.70 11.20 11.40 10.40 11.90 10.90 11.90 11.30 10.80 10.10 10.00 10.50 10.50 10.30 11.60 11.20 10.40 10.40 11.60 10.50 10.90 11.10 9.80 10.20 9.50 10.00 9.60 10.50 9.60 11.00 10.90 9.40 9.90 1196 Company Sanitized. Does not contain TSCA CSf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling GROUP: IV-0 DOSE: 25 MG/KG/DAY DuPont-5386 Animal Number 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 Pup Number Pup Sex 1 2 3 4 5 6 7 8 9 10 too COo ion o CM o GO o GO oo 13 .50 13 .80 12 .40 12 .40 12 .60 12 .10 11 .20 12 .40 12 .30 12 .60 11 .80 12 .90 11 .60 11 .50 10 .7 0 10 .00 10 .00 10 .70 10 .80 11 .30 11 .00 10 .90 10 .30 1 0 ..80 10 10 .80 10 .20 9 . 70 10 .00 13 .20 13 .90 12 13 .20 12 13 .00 11 .70 11 11 12 .60 11 .80 12 .00 11 .90 li .50 10 .20 10 .70 9 . 40 9 . 70 9 . 90 11 .50 9 . 80 9 . 50 8 . 50 9 . 40 9 . 10 6 . 90 11 .20 10 .20 10 .20 9 . 40 1 0 ..20 9 . 90 10 .10 9 . 90 8 . 70 10 .50 9 . 40 10 .10 9 . 70 9 . 80 1 0 ..20 9 . 00 8 . 00 8 . 30 8 . 30 13 .00 11 .20 10 .80 10 .20 10 .00 12 .60 12 .50 12 .10 12 .10 11 .40 12 .00 10 .40 11 10 .50 11 .70 11 10 .00 10 .20 11 .00 10 .90 9 . 60 10 .50 9 . 90 10 .10 10 .80 9 . 90 10 .50 9 . 80 10 .30 1 1 ..70 1 1 ,.30 11 .00 1 0 ..80 1 1 ..20 1 1 ,.60 6 . 10 1 1 ..10 1 1 ..00 10 .10 1 1 ,.20 1 1 ,.70 1 0 ..60 1 1 ..40 1 3 ..50 12 .30 1 3 ..00 12 ..80 13 ..60 12 .60 1 3 . 2 0 1 2 . 8 0 1 2 . 9 0 1 2 . 8 0 1 2 .. 90 1 1 ..40 1 2 ..30 1 1 ..90 1197 Company Sanitized. Does not contain TSCA cel H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group : IV-0 Dose: 25 mg/kg/day Animal Pup Number Sex 1 2 3 Pup Number 4 5 6 7 8 9 10 11 643479 643403a 15.40 12.70 14.50 13.70 13.70 14.40 14.20 643376 643422a 10.40 11.40 11.10 10.50 10.50 10.80 11.10 9.80 9.70 11.70 9.50 10.50 10.00 10.10 643452 643475d 643372 643400 643395 643457 12.40 12.40 11.80 11.50 12.70 12.30 11.10 11.60 12.70 11.00 11.70 11.70 15.10 13.50 10.10 10.20 11.10 11.10 10.40 10.00 12.20 11.00 11.00 9.60 10.30 10.90 10.10 10.90 9.20 9.50 8.60 7.70 8.70 7.10 9.70 9.00 9.30 8.60 7.90 8.60 8.00 8.10 7.80 12.60 13.80 13.40 13.00 13.20 13.20 14.40 12.90 11.70 12.00 11.10 12.60 11.30 11.20 11.60 10.80 10.50 11.50 11.00 10.30 10.50 11.20 11.70 1198 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Animal Number 643320 643488a Group: VI-0 Pup Sex 1 2 . 34 13.50 15.10 14.10 14.00 Dose: 100 mg/kg/day Pup Number 56 7 8 9 10 ll 643428 643439 643353 643385a 643339 643473a 643337 643416 11.20 11.00 10.90 9.90 10.40 10.70 10.20 9.10 10.50 10.60 11.10 9.10 11.00 10.20 10.20 13.60 12.40 13.30 10.20 13.60 12.30 12.00 13.30 10.40 14 .40 16.70 14.70 16.50 15.80 10.80 13.70 15.40 14.60 10.50 10.60 11.70 11.20 11.30 10.40 11.00 11.10 9.60 10.30 8.40 9.90 11.20 10.60 10.90 11.00 11.40 12.70 11.90 12.00 11.50 12.50 11.10 10.60 11.40 12.00 10.70 11.70 8.90 11.50 13.30 13.40 13.90 13.80 10.70 1199 Company Sanitized. Does not contain TSCA oaf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Generation Lactation Day 4 Preculling Group: VI-0 Dose: 100 mg/kg/day Animal Pup Number Sex 643407* 12 Pup Number 3 4 5 6 7 8 9 10 11 6433573 643331e 643427 643470a 643434 643349 643454f 643333 643460 12.50 11.70 11.00 12.10 11.50 11.90 11.30 11.60 11.90 13 .10 11 .70 11 .70 11 .40 12 .00 9.90 8.50 10.90 9.00 8.90 9.50 10.10 10.60 10.00 6.90 10.20 8.30 10.30 10.80 10.40 10.00 9.40 9.10 9.80 8 .40 8 .80 7. 10 8 .60 10 .50 8 .80 8 .90 8 .70 9.00 9,.80 9..80 9,.00 8 .90 8.10 15.60 14.80 12.90 12.10 14.60 13.40 12.40 12.20 13.80 14.00 12.20 11.30 13.50 11.80 12.40 1 2 ,.90 1 2 ,.00 12 .80 1 2 ,.20 1 2 .60 1 1 .90 1200 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Preculling Group: VI11-0 Dose: 250 mg/kg/day Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 643430a Pup Sex 1 10.00 8.50 11.20 12.30 9.50 9.50 . 10.80 9.40 11.40 11.10 10.40 10.40 11.80 9.00 11.60 9.00 2 10.70 8.30 12.10 11.00 13.80 6.80 12.70 11.30 12.00 11.60 10.20 8.80 12.20 9.60 9..90 9.90 3 9.90 10.30 11.90 12.30 9.30 8.30 11.90 10.70 11.30 11.20 9.20 8.40 10.20 11.40 10.30 10.60 4 9.10 8.80 11.90 12.00 7.20 11.80 12.70 11.40 11.30 11.50 11.70 10.50 10.40 11.20 11.20 10.50 Pup Number 56 8.60 10.00 12.80 11.60 9.40 7.90 12.40 10.70 9.20 11.60 11.70 9.80 11.40 9.60 12.50 11.00 10.00 9.70 12.30 10.40 9.30 11.00 10.50 11.70 10.90 9.00 7 9.70 13.30 10.90 11.00 12.10 10.10 9.60 10.30 10.30 8 8.60 10.70 8.20 10.80 11.00 9 10.80 11.10 10.20 6434313 1201 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Preculling Group: VIII-0 Dose: 250 mg/kg/day Animal Number 643326 643365 643375* 643328 643348a Pup Number Pup Sex 1 2 3 4 5 6 11.40 11.70 10.80 9.90 11.00 10.10 11.10 9.70 10.90 11.10 11.30 11.30 11.40 11.30 10.80 9.80 10.50 10.20 10.90 10.30 4.80 10.10 11.30 11.40 7.90 9.80 11.70 9.20 11.40 7 8 9 10 643346* 643449 6434297 643424a 11.10 12.20 10.30 11.30 9.90 9.70 8.40 10.10 9.70 8.60 9.50 10.80 10.40 10.10 8.00 8.60 8.60 * 1202 Company Sanitized. Does notcontain TSCACBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Pi Gnration Lactation Day 4 Postculling Group: II -o Dose : 0 mg/kg/day Animal Number 643352s Pup Sex 1 Pup Number 234 5 643343 643459 643394s 13.00 12.10 12.30 12.30 12.30 11.90 13.80 10.10 12.20 12.10 13.50 13.20 12.60 12.10 14.20 12.' 643480 643319s 14.60 13.30 13.90 12.90 13.40 14.30 13.20 12.20 643350s 643363 643397 643421 10.20 10.40 10.60 10.90 11.20 10.90 10.90 9.50 12.00 11.30 9.20 10.20 11.10 11.00 12.80 9.70 11.20 10.20 12.70 9.20 10.40 10.80 9.80 10.10 DuPont-5386 1203 Company Sanitized. Does not contain TSCA CB H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations____________________DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group :: II -0 Dose: 0 mg/kg/day Animal Number 643420s Pup Sex 1 Pup Number 2 34 5 643419 643414s 643401 643455 643378 643393s 11.60 10.60 10.60 12.10 11.40 11.10 11.20 9.80 11.00 9.00 10.90 10.30 14.10 15.50 10.10 9.10 11.50 9.70 15.50 12.80 9.80 8.40 11.30 9.70 13.40 15.70 10.00 11.60 10.60 16.60 io.: 14.' 643447 643478 643386 10.80 9.50 11.20 10.10 11.20 9.50 6.30 10.80 10.40 10.50 10.50 10.00 9.90 9.80 10.90 10.30 10.90 10.50 10.90 9.90 11.90 11.60 11.10 9.60 Company Sanitized Does not contain TSCA CSl H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Postculling Group: IV-0 Dose: 25 mg/kg/day Animal Number 643399 643334 643464 643369 643490 643342 643438 643445s 643418 643325 Pup Sex 1 Pup Number 2 34 13 .80 12 .40 12 .60 12 .10 ou> 12 .40 12 12 .60 11 .80 oo o CO 10 .70 10 11 10 .30 10 .80 10 .20 9 . 70 10 .00 13 .90 12 .20 13 .20 12 .50 11 .80 12 .60 12 .00 11 .90 10 .20 10 .70 9 . 40 11 .50 8 . 50 9 . 90 10 .20 8 . 70 10 .20 10 .50 9 . 40 10 .20 9 . 00 10 .80 8 . 00 10 .00 8 . 30 12 .50 8 . 30 12 .10 11 .40 12 .00 10 .50 11 .70 10 .20 11 .00 9 . 60 10 .50 10 .80 9 . 90 10 .50 9 . 80 1 1 ..30 1 0 ..80 1 1 ..60 6 . 10 1 1 ..00 1 1 ..40 1 2 ,.90 1 0 ..10 1 2 ,.80 1 1 ..40 1 1 ..20 1 3 ..60 1 2 ,.30 11 .70 13 .20 11 .90 5 6 DuPont-5386 1205 Sanitized. Does not contain tsc a cbi Company H90--2D4a5y6G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group : IV- 0 Dose: 50 mg/kg/day Animal Number 643479 643403a Pup Sex 1 Pup Number 2 345 6 15.40 12.70 14.50 13.70 13.70 14.40 14.20 643376 643422a 10.40 11.10 10.50 11.70 9.50 10.50 10.00 10.10 643452 643475d 643372 643400 643395 643457 12.40 12.40 11.50 12.70 11.60 12.70 11.70 11.70 15.10 13.50 11.10 10.40 12.20 11.00 10.30 10.90 10.10 9.20 8.70 7.10 9.00 7.90 8.60 8.00 8.10 7.80 12.60 13.80 13.40 13.00 13.20 13.20 14.40 12.90 11.70 12.00 11.10 11.20 11.00 10.30 10.50 11.20 DuPont-5386 1206 Company Sanitized. Does not contain TSCA Cfll H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Postculling Group: VI-0 Dose : 100 mg/kg/day Animal Number 643320 643488a Pup Sex 1 Pup Number 234 13.50 15.10 14.10 14.00 5 643428 643439 643353 643385s 643339 643473s 643337 643416 11.00 10.50 10.20 12.00 14.40 10.80 9.90 10.60 13.60 13.30 16.70 13.70 10.40 11.10 13.30 10.40 16.50 15.40 10.20 11.00 10.20 15.80 14.60 13.6 10.50 10.60 11.20 10.40 11.00 9.60 9.90 11.20 12.70 12.00 13.30 10.70 11.90 11.70 13.40 11.50 8.90 13.90 12.50 11.50 13.80 DuPont-5386 1207 Company Sanitized. Does notcontain TSCACBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Postculling Group: VI-0 Dose: 100 mg/kg/day Animal Number 643407* Pup Sex 1 Pup Number -- K-----234 5 643357a 643331e 643427 643470a 643434 643349 643454-f 12.50 11.70 11.00 12.10 11.60 11.90 11.70 11.40 9.90 6.90 10.10 9.00 10.00 10.30 7.10 8.70 10.40 9.80 8.30 8.90 9.40 9.80 8.60 8.90 643333 643460 15.60 14.80 12.40 12.10 14.60 13.40 12.20 11.30 13.80 14.00 12.90 12.20 13.50 12.80 11.90 DuPont-5386 1208 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group : VIII-0 Dose: 250 mg/kg/day Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 Pud Number Pup -- ------ Sex 1 2 3 4 too ou> 10 .70 8 . 30 11 12 .30 9 . 50 9 . 50 11 .90 11 .30 12 .00 11 .60 10 .40 10 .40 12 .20 9 . 60 9 . 90 10 .60 9 . 90 10 12 .10 11 .00 13 .80 6 . 80 9 . 20 10 .70 11 .30 11 .20 11 .70 8 . 80 11 .70 11 .40 10 .30 10 .50 7 . 90 8 . 80 12 12 .30 9 . 30 8 . 30 12 .30 11 .40 11 .30 11 .50 11 .40 8 . 40 9 . 60 11 .20 10 9 . 70 oo o GO 9 . 70 10 .00 12 .40 12 .00 7 . 20 11 .80 10 .90 11 .60 11 .70 9 . 30 11 .00 10 .50 8 . 20 11 .00 10 .80 11 .00 5 643431a DuPont-5386 1209 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 643326 643365 643375* 643328 643348a Pup Sex 1 Pup Number 2 34 11.00 11.70 10.80 9.90 10.90 11.30 11.10 9.70 11.40 10.50 11.30 11.30 10.90 10.30 10.80 4.80 10.10 11.30 11.40 7.90 9.80 11.70 9.20 11.40 643346* 643449 643429J 12.20 11.30 9.90 10.10 10.40 10.10 8.00 8.60 643424s DuPont-5386 % 1210 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group : II-O Dose : 0 mg/kg/day Animal Number 643352s Pup Sex 1 Pup Number 23 4 5 643343 643459 643394s 19.40 18.40 22.70 17.10 18.70 19.00 21.50 20.70 19.60 18.70 22.70 19.00 19.70 18.80 22.40 20.: 643480 643319s 21.20 23.10 20.20 22.90 19.60 21.40 22.20 20.10 643350s 643363 643397 643421 19.40 17.10 17.60 16.90 16.00 14.50 16.90 16.30 20.00 19.40 13.70 15.00 20.70 18.20 22.10 18.80 14.40 15.10 18.90 18.50 18.30 18.10 16.90 15.80 DuPont-5386 1211 Company Sanitized. Does not contain TSCA CBl % H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 7 Group: II-O Dose : 0 mg/kg/day Animal Number 643420a 643419 643414a 643401 643455 643378 643393a 643447-, 643478 643386 Pup Sex 1 19.50 16.20 17.00 14.80 16.90 14.70 19.40 18.40 18.50 17.20 16.70 15.80 18.80 16.80 Pup Number 234 17.90 20.00 18.20 19.00 18.40 18.70 17.50 15.50 17.40 15.70 20.50 22.00 17.00 15.90 17.20 17.30 19.60 22.00 17.40 16.50 15.10 23.00 18.70 18.30 15.70 18.70 15.80 17.20 17.10 17.50 15.60 16.40 15.70 15.20 19.00 19.60 18.80 17.40 15.40 17.90 5 DuPont-5386 % 1212 Company Sanitized. Does not contain TSCA CB( H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 7 Group: IV-0 Dose: 25 mg/kg/day Animal Number 643399 643334 643464 643369 643490 643342 643438 643445a Pup Sex 1 Pup Number 234 19..70 2 1 .30 19,.50 19..00 19..30 19,.70 19,.20 18..80 17,.60 18,.00 19,.30 19..40 16,.70 14,.40 18,.90 15..80 16,.90 17 .30 19,.10 18..00 16,.50 16 .50 16,.30 17..10 15..90 17 .70 16..30 17..50 15,.00 14 .60 16,.40 16,.40 15,.20 17 .00 17,.20 16..90 14 .90 15 .60 16,.00 15..70 16 .80 18 .00 17,.90 19,.30 18 .20 19 .40 18 .80 18..30 16 .40 17 .50 16 .40 18..40 17 .10 15 .80 16 .70 17..40 5 6 643418 643325 9.20 19..30 17..80 18.,80 17 .20 17..70 18..80 18..20 19 .00 22 ,.30 2 0 ,.70 2 2 .80 21 .70 19,.60 2 1 ,.90 19..70 DuPont-5386 1213 Company Sanitized. Does notcontain TSCACBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group : IV-0 Dose : 25 mg/kg/day Animal Number 643479 643403a Pup Sex 1 Pup Number 2 345 6 22.50 21.00 21.40 19.10 18.10 19.60 20.50 643376 643422s 643452 643475d 643372 643400 . 643395 643457 17.70 19.20 15.60 16.80 15.00 16.60 15.10 17.20 19.40 20.10 19.60 18.00 18.30 19.30 18.40 18.20 22.50 20.60 17.90 17.00 18.80 17.90 17.10 17.00 15.50 15.80 12.50 14.40 13.00 10.60 13.40 11.90 12.80 12.20 19.40 20.90 20.40 21.20 19.90 19.00 18.70 20.40 19.90 20.80 19.00 17.90 18.20 18.10 17.80 17.30 DuPont-5386 1214 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations____________ Individual Pup Weights (grams): Pi Generation Lactation Day 7 Group : VI-0 Dose: 100 mg/kg/day Animal Number 643320 643488a Pup Number Pup Sex 1 2 3 4 22.50 21.20 21.30 22.60 5 643428 643439 643353 643385a 643339 643473a 643337 643416 17.10 17.40 18.10 17.80 17.70 17.80 18.50 16.90 20.50 16.90 20.80 16.90 17.10 18:00 20.00 23.50 23.30 21.30 23.50 20.80 22.40 20.50 16.20 17.70 18.10 17.10 17.00 17.50 16.00 17.50 16.30 20.30 19.40 21.70 20.10 18.50 19.50 19.40 15.70 17.70 18.10 19.20 19.00 15.00 DuPont-5386 _________________________________________ 1215 Company Sanitized. Does not contain TSCA CB! H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fx Generation Lactation Day 7 Group : VI-0 Dose: 100 mg/kg/day Animal Number 643407* 643357a 643331e 643427 643470a 643434 643349 643454 643333 643460 Pup Sex 1 Pup Number 234 1 9 . 8 0 1 7 ..80 1 9 ..50 1 9 ..20 1 9 . 1 0 1 9 ..00 1 9 ..30 1 9 ..30 17.10 14.10 16.60 15.40 14 ..90 1 5 ..80 1 7 ..60 13 .. 70 1 5 ..90 1 1 ..40 1 7 ..60 1 4 ..80 1 6 ..90 1 0 ..70 1 5 ..40 1 4 ..00 20.90 20.60 16.20 14.30 22 ..70 1 9 ..70 1 6 ..00 1 5 ..00 2 0 ..20 2 1 ..30 1 5 ..90 1 5 ..10 1 9 ..50 15 ..50 1 3 ..90 5 DuPont-5386 # 1216 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations____________ Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group: VIII-0 Dose: 250 mg/kg/day Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 Pup Sex 1 12.40 11.50 18.80 18.10 20.00 15.00 13.10 16.80 16.50 16.70 19.50 17.20 13.80 16.40 12.20 12.70 Pup Number -- -----234 10.20 13.60 20.10 19.00 12.90 17.20 18.10 16.50 15.90 16.00 19.60 15.40 11.80 16.10 11.80 12.30 13.50 15.60 19.60 19.50 9.60 11.80 16.20 16.90 15.80 14.00 18.30 17.60 17.10 12.00 12.80 10.80 13.80 11.30 20.20 19.50 14.90 9.80 18.40 15.20 16.30 16.50 17.80 15.20 17.90 17.20 11.70 11.90 5 643431s DuPont-5386 fr 1217 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group: VIII-0 Animal Number 643326 643365 643375h -1 Pup Sex 1 14.80 17.70 14.90 12.60 Dose: 250 mg/kg/day Pup Number 234 17.10 16.70 14.10 13.90 18.40 17.80 14.80 12.90 16.90 15.80 13.60 5 643328. 643348a 12.20 17.60 15.00 16.00 16.20 17.30 17.30 14.60 643346* 643449 6434297 . 15.20 15.80 20.30 17.10 17.60 15.30 15.80 13.50 643424a DuPont-5386 1218 Company Sanitized. Does no*contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams) : F]_ Gnration Lactation Day 14 Group: II-O Dose: 0 mg/kg/day Animal Number 643352a Pup Sex 1 Pud Number 234 5 643343 643459 543394a 37.90 36.00 43.70 36.00 40.90 38.10 43.10 40.60 39.20 37.20 44.50 40.50 38.70 37.30 40.60 46.10 643480 643319a 643350a 643363643397 643421 43.30 45.00 43.70 46.30 44.50 41.90 43.30 43.90 38.20 39.60 41.00 34.80 30.60 31.60 42.30 38.80 33.30 35.80 33.30 30.60 43.10 36.80 34.60 33.10 30.30 32.10 41.00 40.10 37.20 35.20 34.80 32.10 DuPont-5386 1219 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group : II-O Dose : 0 mg/kg/day Animal Number 643420a Pup Sex 1 Pup Number 234 5 643419 643414a 43.30 42.10 42.90 41.60 38.50 41.10 40.70 41.30 643401 643455 643378 643393a 35.70 35.00 36.20 32.30 36.70 40.10 35.70 31.30 35.30 30.60 38.90 39.60 36.30 33.80 35.30 34.50 38.10 33.60 37.40 30.50 35.20 37.30 35.30 40.60 643447 643478 643386 39.50 34.00 36.90 37.20 39.80 37.10 37.50 36.40 37.60 36.50 39.20 39.60 37.30 35.50 38.80 38.80 40.20 37.50 34.30 38.00 38.70 37.40 40.90 37.40 DuPont-5386 % __________________________________________________________________1__2_2_0_ Company Sanitized. Does not contain TSCA CBI H90--2D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Lactation Day 14 Generation Group: IV-0 Dose: 100 mg/kg/day Animal Number 643399 643334 643464 643369 643490 643342 643438 643445s Pup Sex 1 Pup Number -- 234 39..90 39,.00 39..10 37..20 37..40 37..30 38..70 36..90 38..30 38,.50 37..60 37 .10 34,.60 38..00 35..30 38..30 40,.10 38..20 41..10 37 .50 38,.20 37..90 37..40 36,.00 37,.90 35,.70 38..30 35..30 37..20 34..40 36. 35..10 37..70 34..30 36..50 33..80 34..80 33..70 36..30 39 .30 41,.70 38..20 42,.70 39..80 38..90 40..30 39..10 34..90 33..80 37,.70 36,.90 37..10 34,.40 36,.50 32,.90 oO CN <N GO m 5 6 643418 643325 39..00 37..80 38,.30 25..10 37 .60 36..10 37,.90 38..10 47 .10 42 .80 46..90 44 .90 43 .20 45..20 46,.40 40..60 DuPont-5386 # 1221 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group: IV- 0 Dose : 100 mg/kg/day Animal Number 643479 6434033 Pup Sex 1 Pup Number 2345 6 39.90 35.10 35.90 40.20 36.70 31.30 34.40 643376 643422a 34.70 34.40 33.70 39.90 31.20 31.00 35.80 32.20 643452 643475d 643372 643400 . 643395 643457 36.30 38.00 36.70 36.90 36.40 37.00 35.80 34.60 39.80 38.50 38.40 39.60 37.00 37.00 35.40 35.80 33.90 32.60 32.20 29.90 27.30 30.70 32.20 30.00 28.90 29.50 37.50 36.80 36.50 38.20 37.30 35.30 37.00 36.10 40.10 40.80 39.30 36.30 38.30 38.60 38.70 37.80 DuPont-5386 ________________________________________1_2_2__2__________________________________ Company Sanitized. Does notcontain TSCA CS H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group: VI-0 Dose: 100 mg/kg/day . Animal Number 643320 643488^ Pup Sex 1 Pup Number -- -----234 44.60 43.00 43.90 41.20 643428 643439 643353 643385a 643339 643473 643337 643416 36.10 36.20 36.40 38.80 40.20 35.40 36.40 34.40 37.80 35.00 38.40 36.20 33.60 32.70 38.70 34.80 39.60 31.40 34.50 33.60 32.50 39.80 38.30 36.10 38.00 38.90 37.10 39.50 34.20 35.50 35.80 38.40 38.50 36.20 32.40 41.30 37.70 36.10 38.80 39.60 35.30 40.70 33.20 38.10 DuPont-5386 % 1223 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: VI-0 Dose: 100 mg/kg/day Animal Pup Number Sex ' 643407^ 1 Pup Number -- 2345 643357^ 643331e 643427 643470s 643434 643349 643454^ 643333 643460 35.70 39.90 36.20 36.80 36.50 37.40 38.20 36.70 31.60 34.40 37.10 34.30 23.50 27.90 30.30 32.60 28.30 34.30 34.40 32.00 30.10 32.20 31.10 29.90 36.30 38.00 40.30 38.80 35.80 35.70 35.60 33.40 34.90 33.20 34.90 32.10 32.20 32.50 33.40 DuPont-5386 # 1224 Seinpaag Sanitized. Does not contain TSCA CB8 H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: VIII-0 Animal Number 643467 Pup Sex 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 1 30.40 25.50 35.10 32.20 34.40 31.50 28.90 25.80 30.70 31.60 29.60 29.60 32.80 36.90 28.10 28.50 Dose: 1000 mg/kg/day Pup Number 2 25.60 34.10 34.00 34.90 26.90 19.60 25.90 26.90 33.00 29.80 31.30 27.10 37.70 35.20 26.90 25.50 34 16.70 30.50 35.30 32.50 20.50 27.90 28.00 26.60 31.00 32.20 31.20 29.00 28.10 33.60 26.00 29.00 5 24.30 23.60 34.80 33.80 28.20 24.90 22.30 26.30 33.10 31.50 29.90 26.80 35.70 31.10 30.10 29.70 DuPont-5386 1225 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group : VIII-0 Dose : 1000 mg/kg/day Animal Number 643326 643365 643375*/! Pup Sex 1 33.40 30.70 30.00 28.00 Pup Number 234 32.50 31.70 29.30 29.00 32.50 33.10 23.30 28.20 30.20 31.80 26.90 643328 643348a 20.80 27.40 24.10 25.20 21.90 23.60 26.40 25.60 643346-! 643449 643429J 643424a 35.50 36.60 31.80 33.30 35.20 33.00 28.80 31.60 DuPont-5386 # 1226 .mparajf Samffiked, oes noi contain TSCA CBi 9H0--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Lactation Day 21 Gnration Group : II -0 Dose: 0 mg/kg/day Animal Number 643352a Pup Sex 1 Pup Number 234 5 643343 643459 643394a 66.50 58.70 72.00 67.40 64.30 61.00 67.80 65.60 65.60 64.00 69.90 59.10 62.70 59.30 71.70 74.1 643480 6433193 70.90 79.00 77.40 73.20 72.50 72.80 71.50 67.40 643350a 643363 643397 643421 67.60 65.30 62.20 55.60 45.70 45.30 68.30 61.80 60.10 57.60 47.60 47.70 66.30 65.20 58.10 57.40 44.20 44.10 73.60 62.00 64.60 55.10 49.50 45.90 DuPont-5386 : 1227 Company Sanftized. Does noicomaln TSCA H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations____________ Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: II-O Animal Number 643420a Pup Sex 1 Dose : 0 mg/kg/day Pup Number 234 5 643419 643414a 62.50 62.30 66.30 63.70 66.80 58.60 63.70 60.50 643401 643455 643378 643393a 57.70 56.20 56.90 54.20 66.70 65.50 61.00 56.00 55.20 49.50 61.60 54.30 56.20 50.30 48.40 57.50 60.40 63.10 57.40 54.00 46.50 59.60 643447643478 643386 58.80 58.60 63.80 58.60 66.90 64.40 62.60 50.70 59.00 61.30 67.90 59.70 56.20 57.50 61.30 63.50 66.30 60.60 59.50 58.40 59.70 58.50 63.00 58.30 DuPont-5386 1228 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 GROUP: IV-0 DOSE: 25 MG/KG/DAY Animal Number 643399 643334 643464 643369 643490 643342 643438 643445^ 643418 643325 Pup Sex 1 Pup Number -- 2 34 59..80 65..50 65..20 67..50 59..40 62..60 64..90 61..40 60..30 61,.90 61..30 63,.20 61..00 61,.80 56..60 58..50 70,.50 6 6 .90 67,.80 6 8 .10 65..20 61,.80 63..70 63,.90 63 .30 59 ,.50 57..20 56..40 56,.80 54..60 55,.70 56..30 55..20 65..40 53 ,.80 58,.10 56,.40 57,.20 52..70 54..50 67,.50 61,.10 67,.80 64,.50 61..70 61,.80 61..90 65 .10 54 ,.30 63 ,.00 56..80 62..00 62..00 53 .90 58,.50 59,.10 61..60 39,.30 59..40 60,.20 57..00 56 .20 56,.10 59..90 68,.70 77 .90 70,.10 72,.90 66..40 66 .60 72 .30 69,.00 5 6 DuPont-5386 1229 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: IV-0 Dose: 25 mg/kg/day Animal Number Pup Sex 1 Pup Number -- ------2 34 643479 . 643403s 70.90 60.40 69.60 60.20 66.10 5 6 643376 643422s 54.00 56.60 58.00 64.30 49.50 55.70 50.10 44.80 643452 643475d 643372 643400 643395 643457 62.50 66.60 60.90 61.70 60.40 60.30 61.00 58.40 66.50 67.00 62.00 66.20 62.80 64.80 55.60 58.00 61.10 56.50 47.00 47.30 51.90 42.10 45.60 43.90 48.20 46.70 61.00 60.60 58.30 59.50 60.50 56.80 58.80 56.00 57.00 61.40 58.40 63.50 56.90 55.60 58.80 59.00 DuPont-5386 ' 1230 Company Sanitized. Does not contain TSCA CSf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 21 Group: VI-0 Dose: 100 mg/kg/day Animal Number 643320 643488a Pup Sex 1 Pup Number 23 4 68.50 GO.50 60.60 65.70 5 643428 643439 643353 643385a 643339 643473 643337 643416 58.40 54.00 59.00 60.40 65.80 64.30 57..10 56..70 61..40 56..50 60,.30 50..20 58..70 54..20 55..10 53..10 66 .10 59..70 52 .10 52 ,.10 60..40 66 .30 59,.00 59.40 60..30 56..60 56..60 53.10 58..80 57..70 55..80 62.60 55.90 61.30 54.30 64..20 61,.40 64 .50 64..40 52,.80 63..30 60 ,.70 62 .50 59..90 DuPont-5386 # _ _ _ _____________________________________________1_2_3__1 Company Sanitized. Does not contain TSCA CB 9H0--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group : VI-0 Dose: 100 mg/kg/day Animal Number 643407* Pup Sex 1 Pup Number 234 5 643357a 643331e 643427 643470a 643434 643349 643454^ 643333 643460 63,.10 61..70 62 .40 6 6 .00 60..80 57..30 57,.80 60..40 59 .20 50,.30 56 .10 53..40 38 .90 45..30 48 .00 51..50 43,.90 56..30 51 .60 55..80 46,.30 48..90 51,.60 49..30 58 .80 6 6 .70 63..70 59..60 61,.60 60,.10 56..10 63 .20 64..90 64..50 59..60 55,.70 57..00 56..00 60..10 DuPont-5386 1232 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fx Generation Lactation Day 21 Group : VIII-0 Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431s Pup Sex 1 43.70 45.10 38.10 35.60 32.00 33.60 31.20 36.10 49.60 50.30 54.60 49.00 43.40 60.30 45.00 44.60 Dose: 250 mg/kg/day Pup Number 2 34 54.00 43.00 39.20 35.10 23.00 22.10 39.50 34.20 50.30 46.10 50.80 45.50 59.10 52.80 46.60 48.90 29.80 54.60 35.70 35.70 29.00 30.30 37.00 34.60 52.80 51.70 56.90 49.00 57.80 55.70 53.60 50.70 42.60 58.40 41.30 39.70 40.00 27.90 40.80 35.80 50.70 47.60 50.70 45.20 52.40 45.60 48.50 49.00 5 DuPont-5386 f t _________________________________________ ________ 1233 ompany Sanitized. Does not contain TSCA CB! H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: VIII-0 Dose: 250 mg/kg/day Animal Number 643326 643365 643375* / 1 Pup Sex 1 Pup Number 234 5 53.70 53.50 49.40 51.20 55.40 50.60 53.50 52.20 39.90 47.10 46.50 44.70 41.80 42.90 44.00 43.60 643328 643348s 34.60 47.50 41.00 43.40 45.50 39.70 45.60 40.40 6433464 643449 6434291 643424s 52.40 53.10 60.40 55.70 47.40 58.40 54.30 51.50 DuPont-5386 1234 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations m DuPont-5386 APPENDIX HH REPRODUCTIVE TOXICOLOGY m INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION % 1235 Company Sanitized. Does not contain t s c a c b i H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION EXPLANATORY NOTES Footnotes a No live pups bom 1236 Company Sanitized. Does not contain TSCA H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fx GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 643343 643459 643480 643363 643397 643421 643419 643401 643455 643378 643447 643478 643386 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED .. NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1237 notcontain TSCACBf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fx GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 643399 643334 643464 643369 643490 643342 643438 643418 643325 643479 643376 643452 643475 643372 643400 643395 643457 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED . NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1238 ConiPany Sanitized. Does no,contain TSCA cbI H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fj GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 643320 643428 643439 643353 643339 643337 643416 643407 643331s 643427 643434 643349 643333 643460 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1239 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 643467 NO ABNORMALITIES DETECTED 643443 NO ABNORMALITIES DETECTED 643417 DAY 21 3 OF 8 2 OF 8 DISCHARGE NOSE BLACK WEAK LITTER SUMMARY : 3 2 DISCHARGE NOSE WEAK DAY 21 PUP DATA: PUP: a DISCHARGE NOSE BLACK WEAK b DISCHARGE NOSE BLACK WEAK c DISCHARGE NOSE BLACK 643413 NO ABNORMALITIES DETECTED 643338 NO ABNORMALITIES DETECTED 643335 NO ABNORMALITIES DETECTED 643468 NO ABNORMALITIES DETECTED 643440 NO ABNORMALITIES DETECTED 643326 NO ABNORMALITIES DETECTED 643365 NO ABNORMALITIES DETECTED 643375 NO ABNORMALITIES DETECTED 643328 NO ABNORMALITIES DETECTED 643449 NO ABNORMALITIES DETECTED 643429a 1240 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX H REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: Fi GENERATION % 1241 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: Fj GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. a No data due to weighing error. DuPont-5386 1242 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 1 8 15 22 29 36 62.7 74.6 73.2 73.6 64.6 49.5 63.7 58.1 54.0 67.2 59.5 59.7 63.0 103.2 132.2 118.0 130.1 115.0 94.7 107.2 98.9 93.7 114.4 101.1 95.2 109.0 156.5 207.8 182.8 201.1 181.8 156.0 176.4 154.7 153.0 179.9 167.6 158.8 162.3 204.0 279.5 248.8 264.2 243.5 213.7 250.0 215.9 218.3 250.6 227.3 228.7 227.5 251.7 352.7 310.2 336.7 307.8 265.6 325.4 257.3 279.2 282.6 273.9 302.6 285.8 303.9 411.7 326.6 333.8 367.0 325.4 314.3 323.3 284.7 366.5 349.4 325.9 302.2 1243 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fi MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 1 8 15 22 29 36 67.5 63.2 68.1 56.4 58.1 64.5 62.0 60.2 72.9 70.9 64.3 61.7 64.8 42.1 59.5 63.5 106.2 108.5 103.3 97.6 103.5 105.7 102.2 107.1 122.8 113.1 104.3 108.7 103.4 73.3 95.2 108.2 176.4 172.2 158.8 156.8 166.5 163.7 167.0 168.5 187.5 176.0 165.5 170.8 164.4 118.6 145.1 165.0 230.8 236.4 213.2 215.0 225.8 232.3 234.8 237.5 242.4 231.0 224.4 231.7 229.1 171.6 207.3 220.4 301.6 282.6 278.2 276.4 290.2 247.0 260.1 293.3 319.2 285.7 280.5 308.6 279.2 222.2 261.9 272.8 _a 343.9 304.5 336.7 348.4 341.2 283.5 363.8 383.2 341.5 302.5 376.1 311.9 276.8 324.0 339.1 # 1244 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP : V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 1 8 15 22 29 36 60.5 52.1 48.2 66.3 56.6 60.7 59.9 66.0 53.4 55.8 63.7 59.6 99.6 92.8 81.8 114.4 98.8 106.5 98.0 109.8 96.1 94.4 104.7 108.8 151.8 150.0 135.3 181.3 167.6 168.7 158.9 175.1 157.7 150.7 165.0 173.0 217.6 212.6 203.5 244.6 221.1 231.2 223.3 237.6 225.3 210.1 223.4 225.2 264.4 279.5 232.7 315.5 302.2 267.4 280.7 275.2 286.7 274.0 288.7 283.9 276.6 298.2 259.1 382.7 375.5 299.1 300.9 305.1 300.2 300.1 313.4 314.5 1245 Company Sanitized. Does not contain TSCA CB1 H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fi MALE RATS GROUP : VII-1 DOSE : 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 1 8 15 22 29 36 42.6 41.3 40.0 40.8 50.7 50.7 52.4 48.5 51.2 46.5 43.4 55.7 86.3 91.5 96.7 82.1 96.4 85.3 87.4 83.9 84.8 80.3 80.5 100.9 137.5 144.5 170.4 139.6 158.8 143.5 143.3 139.6 131.4 135.8 133.4 155.8 203.2 211.9 224.0 197.3 221.1 200.7 209.1 210.9 190.5 202.0 187.0 214.3 258.8 272.7 344.6 252.2 281.3 255.5 259.0 242.8 239.8 270.4 245.1 246.2 318.3 331.9 417.0 280.9 296.9 275.0 318.9 265.3 299.5 277.7 313.3 327.4 1246 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: II-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 1 8 15 22 29 36 59.3 59.1 67.4 62.0 55.1 45.9 60.5 50.3 46.5 63.1 58.4 58.5 58.3 96.0 103.1 103.8 99.6 96.4 84.1 93.2 85.0 78.1 95.5 102.2 94.0 91.4 130.3 139.6 136.8 143.7 144.1 132.3 139.9 122.5 121.7 137.1 156.4 135.0 126.3 156.9 160.9 152.2 180.4 185.9 163.3 179.6 158.2 155.0 181.8 185.8 167.0 150.2 177.1 182.7 170.8 199.8 204.7 192.7 207.7 173.2 176.8 210.2 217.7 194.6 161.6 203.4 201.4 179.7 221.4 219.6 212.8 219.6 200.7 191.0 211.6 231.0 213.7 176.7 1247 Company Sanitized. Does not contai_n TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP : IV-1 DOSE : 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 1 8 15 22 29 36 61.4 58.5 63.9 56.3 54.5 65.1 59.1 59.9 69.0 60.5 44.8 58.4 67.0 56.5 46.7 56.0 59.0 91.7 97.0 98.2 96.0 92.1 106.5 98.1 99.4 108.8 100.3 77.6 95.5 99.0 87.9 79.5 86.7 97.5 138.6 143.9 137.7 146.2 141.0 158.4 150.9 145.1 171.7 140.9 114.8 137.8 137.1 124.0 120.6 123.3 140.4 161.4 186.5 168.8 181.1 176.9 212.3 196.4 180.0 220.4 162.9 137.3 171.9 171.9 155.7 150.5 151.1 168.3 186.1 204.9 192.1 209.8 201.1 246.4 223.6 191.4 232.3 171.7 146.5 195.8 200.7 174.7 172.1 180.4 196.1 _a 223.5 206.5 228.5 223.2 283.9 242.1 203.7 280.7 197.7 164.9 222.7 218.1 196.8 192.7 196.2 219.3 % 1248 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: VI-1 DOSE : 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 1 8 15 22 29 36 65.7 52.1 53.1 59.0 55.8 62.5 54.3 60.4 51.5 49.3 56.1 60 .1 101.8 88.9 90.3 91.5 96.1 84.0 86.5 97.6 87.6 77.8 84.3 98.2 143.2 135.5 131.5 125.9 138.5 142.2 132.0 141.8 130.8 117.1 123.9 141.0 167.7 166.5 164.1 161.1 177.8 184.3 166.2 177.2 170.3 142.0 160.1 173.0 193.1 194.3 185.0 167.7 211.5 209.8 190.3 204.7 200.8 159.8 181.8 198.3 213.2 215.3 206.8 194.1 235.8 235.6 215.2 222.1 219.3 173.7 196.9 222.9 # 1249 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 1 8 15 22 29 36 58.4 39.7 27.9 35.8 47.6 45.2 45.6 49.0 52.2 43.6 40.4 51.5 97.2 88.5 68.1 70.4 78.5 76.6 77.8 80.2 84.9 69.1 73.8 94.5 142.1 124.3 117.6 113.2 125.8 123.3 118.3 . 124.3 127.3 115.4 124.6 141.4 176.2 157.1 166.1 143.3 167.8 162.1 153.4 157.1 157.0 158.3 163.2 178.9 203.5 190.5 210.4 170.6 190.7 189.6 164.3 183.4 173.4 186.7 190.3 199.1 197.3 194.5 238.3 193.8 219.7 209.0 187.7 210.1 206.9 217.1 202.0 198.8 1250 Company Sanitized. Does noi oonlain TSCA CM H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX JJ REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION m 1251 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. a No data due to weighing error. DuPont-5386 1252 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 1-8 -15 15-22 22-29 29-36 1-36 40.5 57.6 44.8 56.5 50.4 45.2 43.5 40.8 39.7 47.2 41.6 35.5 46.0 53.3 75.6 64.8 71.0 66.8 61.3 69.2 55.8 59.3 65.5 66.5 63.6 53.3 47.5 71.7 66.0 63.1 61.7 57.7 73.6 61.2 65.3 70.7 59.7 69.9 65.2 47.7 73.2 61.4 72.5 64.3 51.9 75.4 41.4 60.9 32.0 46.6 73.9 58.3 52.2 59.0 16.4 -2.9 59.2 59.8 -11.1 66.0 5.5 83.9 75.5 23.3 16.4 241.2 337.1 253.4 260.2 302.4 275.9 250.6 265.2 230.7 299.3 289.9 266.2 239.2 % 1253 Company Sanitized. Does not contain TSCA CB! H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 1-8 8-15 15-22 22-29 29-36 1-36 38.7 45.3 35.2 41.2 45.4 41.2 40.2 46.9 49.9 42.2 40.0 47.0 38.6 31.2 35.7 44.7 70.2 63.7 55.5 59.2 63.0 58.0 64.8 61.4 64.7 62.9 61.2 62.1 61.0 45.3 49.9 56.8 54.4 64.2 54.4 58.2 59.3 68.6 67.8 69.0 54.9 55.0 58.9 60.9 64.7 53.0 62.2 55.4 70.8 46.2 65.0 61.4 64.4 14.7 25.3 55.8 76.8 54.7 56.1 76.9 50.1 50.6 .54.6 52.4 _a 61.3 26.3 60.3 58.2 94.2 23.4 70.5 64.0 55.8 22.0 67.5 32.7 54.6 62.1 66.3 _a 280.7 236.4 280.3 290.3 276.7 221.5 303.6 310.3 270.6 238.2 314.4 247.1 234.7 264.5 275.6 1254 Company Sanitized. Does not contain tscacbI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 1-8 8-15 15-22 22-29 29-36 1-36 39.1 40.7 33.6 48.1 42.2 45.8 38.1 43.8 42.7 38.6 41.0 49.2 52.2 57.2 53.5 66.9 68.8 62.2 60.9 65.3 61.6 56.3 60.3 64.2 65.8 62.6 68.2 63.3 53.5 62.5 64.4 62.5 67.6 59.4 58.4 52.2 46.8 66.9 29.2 70.9 81.1 36.2 57.4 37.6 61.4 63.9 65.3 58.7 12.2 18.7 26.4 67.2 73.3 31.7 20.2 29.9 13.5 26.1 24.7 30.6 216.1 246.1 210.9 316.4 318.9 238.4 241.0 239.1 246.8 244.3 249.7 254.9 1255 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: VII-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 1-8 8-15 15-22 22-29 29-36 1-36 43.7 50.2 56.7 41.3 45.7 34.6 35.0 35.4 33.6 33.8 37.1 45.2 51.2 53.0 73.7 57.5 62.4 58.2 55.9 55.7 46.6 55.5 52.9 54.9 65.7 67.4 53.6 57.7 62.3 57.2 65.8 71.3 59.1 66.2 53.6 58.5 55.6 60.8 120.6 54.9 60.2 54.8 49.9 31.9 49.3 68.4 58.1 31.9 59.5 59.2 72.4 28.7 15.6 19.5 59.9 22.5 59.7 7.3 68.2 81.2 275.7 290.6 3.77.0 240.1 246.2 224.3 266.5 216.8 248.3 231.2 269.9 271.7 1256 Company Sanitized. Does not contain TSCA Cl H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fi FEMALE RATS GROUP: II-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 36.7 44.0 36.4 37.6 41.3 38.2 32.7 34.7 31.6 32.4 43.8 35.5 33.1 34.3 36.5 33.0 44.1 47.7 48.2 46.7 37.5 43.6 41.6 54.2 41.0 34.9 26.6 21.3 15.4 36.7 41.8 31.0 39.7 35.7 33.3 44.7 29.4 32.0 23.9 20.2 21.8 18.6 19.4 18.8 29.4 28.1 15.0 21.8 28.4 31.9 27.6 11.4 26.3 18.7 8.9 21.6 14.9 20.1 11.9 27.5 14.2 1.4 13.3 19.1 15.1 144.1 142.3 112.3 159.4 164.5 166.9 159.1 150.4 144.5 148.5 172.6 155.2 118.4 # 1257 Company Sanitized. Does not contain TSCA CBl H90--2D45a1y6G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj. FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 1-8 8-15 15-22 22-29 29-36 1-36 30.3 38.5 34.3 39.7 37.6 41.4 39.0 39.5 39.8 39.8 32.8 37.1 32.0 31.4 32.8 30.7 38.5 46.9 46.9 39.5 50.2 48.9 51.9 52.8 45.7 62.9 40.6 37.2 42.3 38.1 36.1 41.1 36.6 42.9 22.8 42.6 31.1 34.9 35.9 53.9 45.5 34.9 48.7 22.0 22.5 34.1 34.8 31.7 29.9 27.8 27.9 24.7 18.4 23.3 28.7 24.2 34.1 27.2 11.4 11.9 8.8 9.2 23.9 28.8 19.0 21.6 29.3 27.8 _a 18.6 14.4 18.7 22.1 37.5 18.5 12.3 48.4 26.0 18.4 26.9 17.4 22.1 20.6 15.8 23.2 _a 165.0 142.6 172.2 168.7 218.8 183.0 143.8 211.7 137.2 120.1 164.3 151.1 140.3 146.0 140.2 160.3 A ,,a*,TSCACB)1258 Company S a r t ia . Doe, no, H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx FEMALE RATS GROUP: V I-1' DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 1-8 8-15 15-22 22-29 29-36 1-36 36.1 36.8 37.2 32.5 40.3 21.5 32.2 37.2 36.1 28.5 28.2 38.1 41.4 46.6 41.2 34.4 42.4 58.2 45.5 44.2 43.2 39.3 39.6 42.8 24.5 31.0 32.6 35.2 39.3 42.1 34.2 35.4 39.5 24.9 36.2 32.0 25.4 27.8 20.9 6.6 33.7 25.5 24.1 27.5 30.5 17.8 21.7 25.3 20.1 21.0 21.8 26.4 24.3 25.8 24.9 17.4 18.5 13.9 15.1 24.6 147.5 163.2 153.7 135.1 180.0 173.1 160.9 161.7 167.8 124.4 140.8 162.8 1259 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:avSaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF F 1 FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 38.8 48.8 40.2 34.6 30.9 31.4 32.2 31.2 32.7 25.5 33.4 43.0 44.9 35.8 49.5 42.8 47.3 46.7 40.5 44.1 42.4 46.3 50.8 46.9 34.1 32.8 48.5 30.1 42.0 38.8 35.1 32.8 29.7 42.9 38.6 37.5 27.3 33.4 44.3 27.3 22.9 27.5 10.9 26.3 16.4 28.4 27.1 20.2 -6.2 4.0 27.9 23.2 29.0 19.4 23.4 26.7 33.5 30.4 11.7 -0.3 138.9 154.8 210.4 158.0 172.1 163.8 142.1 161.1 154.7 173.5 161.6 147.3 1260 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX KK REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: F, GENERATION 1261 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:avSaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. DuPont-5386 # # 1262 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fi MALE RATS GROUP : 1-1 DOSE : 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 1-8 8-15 15-22 22-29 29-36 1-36 12.3 15.2 12.7 15.3 12.6 14.4 12.0 12.7 11.0 13.5 12.0 11.1 12.0 20.5 22.8 20.1 23.6 20.0 18.8 20.6 18.7 18.2 19.6 20.3 18.6 18.0 20.4 27.3 25.1 27.1 23.6 23.3 25.1 22.7 22.9 25.5 23.7 24.1 23.8 22.9 30.3 26.7 31.1 26.1 24.8 30.3 23.9 27.8 25.0 25.6 29.5 27.0 25.6 9.2 26.1 24.4 10.2 9.5 21.8 12.8 23.3 30.9 31.0 26.2 25.8 20.3 21.0 22.2 24.3 18.5 18.2 22.0 18.2 20.6 22.9 22.5 21.9 21.4 1263 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 1-8 8-15 15-22 22-29 29-36 1-36 11.5 11.9 11.7 11.0 11.5 13.2 12.2 13.3 14.1 12.2 11.8 14.1 11.9 9.8 10.9 14.0 19.4 19.6 18.0 17.2 18.1 19.2 19.3 20.1 20.4 18.9 18.8 21.2 19.6 15.1 15.3 19.0 23.5 23.1 21.8 21.4 22.7 24.6 24.9 24.5 25.0 22.0 21.9 24.6 25.0 19.8 20.6 22.2 26.7 24.3 25.0 25.7 25.6 21.6 24.1 28.1 28.8 22.7 23.8 31.2 25.4 22.5 22.8 24.7 46.6 26.5 24.0 2.3 7.8 28.6 22.8 31.1 28.5 25.9 22.9 14.4 25.2 25.2 25.4 15.5 25.5 21.1 20.1 15.5 17.1 21.4 20.7 23.4 23.4 20.3 19.8 21.1 21.4 18.5 19.0 19.1 # 1264 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fj. MALE RATS GROUP : V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 1-8 8-15 15-22 22-29 29-36 1-36 10.7 11.6 9.6 13.7 12.0 12.4 11.5 12.9 11.1 11.3 11.6 15.6 16.9 18.6 17.4 20.9 20.6 20.9 19.1 20.6 18.4 17.1 18.7 21.2 21.7 24.4 24.9 26.0 24.2 25.9 25.2 24.7 24.4 21.8 23.3 22.8 25.0 29.4 26.0 29.3 30.2 26.1 28.2 26.2 29.5 26.3 27.2 24.5 21.1 25.7 23.5 17.7 15.4 27.2 25.2 25.4 24.6 24.9 26.2 25.5 19.1 21.9 20.3 21.5 20.5 22.5 21.8 22.0 21.6 20.3 21.4 21.9 1265 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx MALE RATS GROUP : VII-1 DOSE : 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 1-8 8-15 15-22 22-29 29-36 1-36 12.0 12.8 12.5 10.9 12.9 10.3 11.0 10.3 11.2 11.2 10.1 12.8 18.0 15.0 19.4 16.9 19.5 16.8 17.9 17.3 17.2 15.7 16.2 18.5 23.4 22.4 24.7 20.8 25.3 21.6 23.3 24.5 21.4 23.2 20.1 22.4 26.0 28.1 34.5 24.1 28.7 24.3 26.0 24.7 24.8 27.4 23.6 22.7 28.0 4.2 8.1 23.0 24.2 23.9 28.3 23.5 25.7 24.7 26.5 28.0 21.5 16.5 19.8 19.1 22.2 19.4 21.3 20.1 20.1 20.4 19.3 20.9 % 1266 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:avSaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F 1 FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 12.1 12.5 11.2 11.0 11.9 11.4 10.8 12.4 9.6 11.0 13.2 11.4 11.0 16.1 17.1 15.8 15.6 16.9 16.3 16.6 15.3 15.4 15.5 20.9 17.0 15.2 18.6 16.6 15.4 17.5 18.6 17.7 20.1 17.9 17.7 18.3 18.9 17.7 16.3 18.5 17.1 14.9 17.9 18.7 18.8 20.1 16.7 17.2 20.6 20.9 18.3 16.0 19.5 17.7 15.4 17.8 18.5 18.5 18.5 17.4 17.3 17.8 20.4 18.3 15.5 17.0 16.2 14.6 16.0 16.9 16.5 17.2 15.9 15.5 16.6 18.9 16.6 14.8 1267 company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 9.9 12.8 12.2 11.6 10.9 13.3 11.6 12.3 12.3 13.1 9.0 11.8 10.5 10.7 10.2 10.8 11.9 16.8 16.9 16.4 16.2 15.4 19.3 18.4 16.1 20.2 18.2 13.7 17.1 16.3 14.9 15.4 15.1 16.7 17.3 19.9 17.4 18.4 18.3 23.4 22.4 17.4 23.3 17.2 14.9 19.9 17.3 16.6 16.3 15.8 17.0 17.3 18.1 17.4 19.7 18.2 23.0 21.5 16.9 22.3 16.2 14.4 20.2 18.1 15.8 16.8 16.8 17.6 46.8 19.4 17.2 20.4 18.8 25.9 23.7 14.7 27.0 18.0 15.5 22.5 17.3 15.4 17.2 16.6 18.1 21.6 17.4 16.1 17.3 16.3 21.0 19.5 15.5 21.0 16.5 13.5 18.3 15.9 14.7 15.2 15.0 16.2 1268 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx FEMALE RATS GROUP: VI-1. DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 11.4 11.7 11.1 10.7 12.8 7.9 10.5 13.5 13.1 9.4 9.4 11.7 15.7 16.3 16.6 14.3 16.0 18.3 16.4 17.7 16.2 15.6 15.1 18.4 16.5 17.7 19.8 17.0 18.5 19.9 19.5 19.7 19.6 15.5 16.9 20.9 16.8 19.0 19.5 16.1 20.1 21.3 20.3 19.6 19.7 15.8 17.5 21.5 17.7 19.4 19.9 16.0 19.8 21.5 19.7 20.2 19.9 15.6 17.1 20.9 15.6 16.8 17.4 14.8 17.5 17.8 17.3 18.1 17.7 14.4 15.2 18.7 1269 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F 1 FEMALE RATS GROUP: VIII-'l DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 - 12.0 12.8 10.2 9.7 10.2 9.6 10.6 9.6 11.3 8.5 9.0 12.2 17.7 15.7 14.8 14.6 15.1 14.5 14.9 16.0 16.8 14.5 16.5 18.5 18.5 17.6 18.6 16.6 18.6 17.5 17.2 17.2 16.4 12.0 19.6 19.6 19.8 19.8 19.5 17.5 19.4 17.6 17.1 18.0 16.7 18.9 19.0 20.5 16.5 14.2 19.4 18.4 19.8 17.9 17.0 18.9 18.3 19.6 20.2 17.5 16.9 16.0 16.5 15.4 16.6 15.4 15.4 15.9 15.9 14.7 16.9 17.7 1270 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:aSvaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX LL REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS: Fi GENERATION % 1271 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:avSaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS: F, GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. DuPont-5386 1272 Company Sanitized. Does not contain TSCA CBI 9H0--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERV 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 19 19 19 19 18 18 20 20 19 19 19 19 19 19 19 19 20 20 20 20 20 20 27 27 20 20 1273 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G:avSaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: II-1 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 14 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 20 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 21 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 21 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 21 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 22 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 20 PREPUTIAL SEPARATION COMPLETE 23 SACRIFICED BY DESIGN TEST DAY 40 . PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 24 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 21 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 22 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 20 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 20 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 27 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 26 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 22 14 20 21 21 21 22 20 23 24 . 21 22 20 20 27 26 22 1274 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 20 20 25 25 29 29 20 20 23 23 22 22 27 27 20 20 23 23 27 27 20 20 22 22 1275 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: VII-1 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 24 24 21 21 20 20 24 24 23 23 20 20 21 21 23 23 24 24 24 24 27 27 21 21 # 1276 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 88 10 10 99 14 14 12 12 12 12 13 13 13 13 12 12 18 18 12 12 12 12 12 12 1277 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 12 12 11 11 19 19 12 12 15 15 13 13 11 11 12 12 13 13 40 40 11 11 11 11 88 13 13 12 12 11 11 11 11 13 13 1278 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY DuPont-5386 ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 ; 12 17 11 10 12 14 12 13 11 12 11 10 12 17 11 10 12 14 12 13 11 _ 12 11 10 1279 Company Sanitized. Does not contain TSCA CBI H90-2-D45a1y6G:avSaugbechSrtoundiyciTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 10 10 11 11 20 20 11 11 13 13 12 12 12 12 12 12 12 12 14 14 12 12 11 11 1280 Company Sanitized. Does not contain TSCA CBI