Document 1yy03ggXeB3OnZdNjOKRQ8ond

CL) 3 ARE-0366 `AAtrttahcuhreMdeanrdeelc,omPrmoejnetcst 9o9n7t0h6e1326M43TeFcahtneiocaflFlRueoproorcthe"Amniaclayltsi,caRleMpeotrhtoNdoo.lo8,gyJana.nd17S,up1p9o7r9t". made by Professor Stephen A. Boyd, Michigan State University, dated May 19, 1993. 006506 Review of Technical Report Summary Analytical Methodology and Support Discussion and Results Tcohrereolcattainonolb-ewtatweerenpatrhteitoicotnacnooelffwiactieerntpoarftFitMion3c4o2e2ffwiacisenrtepaonrdtetdheassol6u.b6ilxit1y0i.n There water is a strong for organic Solutes given by the equation (Chiou et al., 1982, Eaviron. Sci. Technol. 16:4-10). log Kou = 0.862 log S, + 0.710 This relationship the K, value of 6w.o6uxld10pr.ediFcotratshuepKerncoaonldedS,l,iqvuailduessoltuobibleitcyoomfpactai.b4l7eprpebquFirMe 3422 based on that either FM 3>4212007sCathleinqutihdeaatctruoalomsoltuebmipleirtyatsuhroeulodrbhealvoewaerl(ow~ 1m0exl)titnhganpotihnetpr(e<d1i0ct0edC)s.upeIrfcotohleedm.lpi.quiids Seoiltuhbeirlitthye,mie.ea.s,uarbeodutK.5,,poprbinisstepardoboafb5ly0 pwprbo.ng.If tThheem.rpel.atoifonMshFip3r4e2f2erirsed>t1o0i0n ttohe1r5epCorttsheins by the same group (Chiou 2 looksa litle different et al.) and I think than the equation this is above. a useful exercise. The The main cautionary line plotted in note is that Fig. these relationships predict (>100 to 150C) the the supercooled liquid solubility of solids. actual water solubility may be substantially If the (~ 10x) solid has a high m.p. lower. When working Swoiltuhbitlhietsyeoefqutahteiosnosl,idy.ouAnteeadnyto rpaltoet,tihteissuapergcoooodleedstliiqmuaitde stoolugbiilvietyynoout tahne imdeeaasuorfewdhaeqrueeotuhse experimental value should fall. It also emphasizes the importance and utility of obtaining accurate S,, and Ky values. bSiemtiwleaernesBtCimFataesndofebiitohecronKceyntroartiSo,n, fwaicttohrsea(cBhCEs)peccainesbe(o.bgt.a,intreodutf,rogmupepmipci)riyciaelldrienlgatiitosnsohiwpns relationship. lipid content, A unified analogous relationship can be obtained by to normalizing the soil sorption normalizing the BCF of coefficient, K, tothesoil a species by its organic carbon cdoifnfteernetnttospgeicvieesK.o.f. aqTuhaetincoorrmgaalniizsemdsf(ac.tgo.r,, zBoCoFp,l,anikstolnin,eagrupwpiitehs,S,raainndboKwytroounta, clatofgisshc)a.leTfhoer equation is: . log BCF, = 0.899 log K,, + 0.623 (from Chiou, 1985, Environ. Sci. predicting BCF values for different Technol. 19:57-62). This equation has the advantage species, as long as you know their lipid content. of AmosbimleitniteisoonfedFCea9rl5iearn,dtFheCso1i4l3 TveLrCsusplFatMes 3a4r2e2 odfeslpiimtietetdhevfaalcute.thatTthheeyfodridmne'rttdwiostciongmupioshuntdhse have much lower soil sorption coefficients than the latter. Hence, the assay seems insensitive. 006507 Experimental The water solubility here is reported as ppm or 100 times the 0.05 ppm value discussed above. "aTphpiasrehnats stoolubbielidtey;tetrhmeicnoedmpaocucunrdatleilkye.ly hMaisceslurlfeacftoarnmtaqtuiaolnitimeasyjuodcgciunrg farnodm rietssuslttruicntutrhei.s hYioguh should know concentration if it forms micelles. This (CMC). There are a variety is of easily done methods for by this measuring the determination. critical micelle Sorption of this compound by soil may be quite different above and below the CMC. `Water solubility determinations. The differenceof 43 times in the water solubilitiesofFM 3925 are FM 3422 seems rather large considering the high degree of structural similarity. Recommendation 1. Obtain an accurate water solubility for FM 3422 and 3925. 2. Obtain an accurate octanol-water partition coefficient for FM 3422 and 3925. 3. Dcoentceernmtiranteioinfs.FM 3422 and 3925 form micelles, i.e., measure the critical micelle *A key reference describing methodology for determining water solubility and octanol-water partition coefficient is: Cpa.rTt.itiCohnicoouefafnicdieDn.t aWn.d wSacthemredsodliunbigl.ityo19f8o0r.gaMneiacscuhremeimceanlst."anAdssionctieartprieotnatoifoOnfofifcoiacltaAnnoall-ywtaitcearl Chemists. Washington, D.C. 006508