Document 1ymEkmKw63nJLxQ0MmKmyRxV5

2U m in u te s PAPERS AVAILABLE IQ,. USE ON AIHA PF OGi^AM A?ML 1946 KFilEi ING 'IABOPATTTY OF APPLIED PHYSIOLOGY ' 1. Experimental Observations on the Ingestion of Aluminum by a Normal Human Subject, by ..obert A. Kehoe, et al. A;study of the alimentary absorption of certain aluminum compounds administered daily to an experimental subject ever some period of time at different levels of dosage. Balance experiment vith daily observations on intake by mouth in food and ou.put in feces and urine, accompanied bj blood level determinations and clinical oboe r-va ..ions . Lemons aat^oa of the negligible alimentary absorption A fev additional observations obtained under other conditions demonstrate the absorbability of respired aluminum. 2. Furchei- Observations on the Ingestion of Lead by Normal Human Subjects1, ^he Daily Ciel Lounge Compatible vith a Balanced Lead Metabolism, by .. ober l A. Hehoe, et al. Continuation of the observations previously described culminating In the demonstration of the approximate level of daily lead ingestion (and absorption; that results in no nrogressive lead accumulation in .he body. 3. The Urinary Fluorine Excretion of Men Employed in Alkylation Plants Using the Hydrogen Fluoride Process, by Edvard J. Larger" (Could possibly be coordinated vith description of exposure (processes involved} in such plants and discussion of actual hazard VLkXjT raiArvr.canaoauntM'sa Hwi. v9a of Universal Oil Products Company if desired., Actual data from a number of plants; some observations repeated cn several occasions, with comments on significance. 4. The Metabolism of Fluorine in the Human Subject. The Excretion of Detained Fluorine, by Edvard J. Largent Continuation of systematic studies on the behavior of 2o m inutes 15 m inutes 2i> m in u te s m inutes Any one o f these w ould re q u ire from 2u to 3>u m in u te s to p r e s e n t. fluorine In the human body, these having to do vlth the rate of loss of fluorine from the body following absorption sufficient to result in retention of fluorine in the tissue. 5. The Paysiological Effects of the Absorption of Xylidlne Upon Experimental Animals, by Joseph F . Treon A systematic toxicological investigation of this compound. The results could be compared vith those of monomethyl aniline and the general effects of acsorption of this series of compounds could be commented upon, using illustrative data. Neal and his associates at Bethesda, Maryland, have done a great deal of work on Xylidlne and if desirable an effort could be made to have a joint presentation of the high spots of both Investigations. If this were done, perhaps 4u minutes for both would suffice, one taking a little more than the other to present the general considerations. 6. Other compounds investigated by Dr. Treon and his asso ciates are ready for reporting in a manner similar to that indicated above, are; (a; aminodiazine and me Lhylaminopyrimidine; (bj methyl acrylate and ethyl acrylate; (c) hexachlorobutadiene, hexachloropropyleae and penta- chloropropylene. 7. Further toxicological work on several compounds could be presented by one or another of the staff members who have been engaged in the work. (a; f-aminothlazole* (b) orthonitrodiphenyl and related compounds (plasticizers;* (c; tetraethyl tin* (dj trimethyl phosphate. a ; >J m in u te s b j 50 m in u te s c) 1j m inutes d) 15 m inutes 15 m inutes In some Inalances ve may require releases from secrecy orders in Order to be able to deal with the subject matter of these investigations. Therefore those in this group as well as certain of those in group 6 must be regarded as tentative and, therefore, are not to be given any publicity at this time beyond the -program committee. We shall be able to act promptly, however, if a specific paper happens to fit well into your program. 6. Hew Analytical Methods as developed by J. Cholak, Waldo Younker and Donald Hubbard. (aj The Determination of DDT in Air - (YounkerJ A method suitable for analysis of air for DDT content in industrial plants or other establishments, or in connection with experimental work with animals. (b> The Determination of Antimony in Biological Material Uiubbard; A precise method for dealing with small quantities of antimony in tissues, blood and excreta. 9. Our work on the Toxicology of DDT could be assembled and suitable portions of it prepared for the purposes of this meeting if desired. If this were done, certain aspects of the problem might well be dealt with by Neal and his associates and by the other groups that have been engaged in this work for some time. I hardly think this the most suitable meeting for presentation of this subject, but am willing to defer to the wishes of the Committee.