Document 1yK2e6o4eb6Gv44nKmLqxG0dq

Acute L e t h e r n i a in Two Cenentions Following Chronic Exposure to BenzeneL ?*I. ; i W O Y , S . ERDEY,GCLTENEP.D~G.-\s2cd GL\~;*G Di>iLor Secctionc of HJrrna!clrjy 2 r l l Cece:iu. Ir.!cr;?zl CTi?:ic= i I;!anbtri .!.:&.CY! Sc>oal, CJ?a. r%:3?15@~1 i t T Abwucr. Two cuo of acute !eukaemi3. one !)mphob:asti; 2nd KrJ-f4br;'J tire orker rnjcloblastic, f d l o u i n g ch:onic txposurc to tenz:ar in two rclatiws, 2 m3n and his pat:mal uncle, arc pruen:cd. T h e possibly sigdiunt role of genetic prcaispojition is discussed. fr .+cute !euk>enia 4 .-k:ia?c&d faston i Fxniiill x c u r ~ C C.? as conclu!:d that some zerc:ic f x t o n were ?ii33:4 by c h r w i c exposure to Srnz:ne in thzs pa:ienfs. !* < ! +The indilidual siijs:$ibility IIX S t e n conjid<r:d 0i:t of :!le main fxtors 3 in the incidence of chronic benzerx poisoninp ( B R O ~ S I S C .1965;. Tker: zre selveral studies i n favcur of 3 grcxc variitian in iadi\idclal jGj:optil?i:it:/ .t [REJSEKand Reiskova, 1955; S.A!ILAHT1T9.55; Aicsov et cl., 197!j. Tr,: 5 cause o.-ihis variation is not compldeIy understood. Accordins to BXOW:--~S-$C -4[I9651'the most probab!e explanation lies in inn3:e dlffzrecces in th2poterlcy 4of dife:ent individuals to carry out the metabolic de!oxic3!ion'. As early as 1922 REIFSCHSEIDERsuggested 3 possible firni!y sujceptibility. Il'e c2.n g i v t .$ +some examples from o w series of chronic benzene p o i j o ~ n gin support o f f this assumption. Two of our thalasjaemic patieEts with ap1as;ic s n x m i a dire to chronic benzene exposure, one fatal. werc brotkcrs [XKSOY2nd EWE>!. 119691. Also two patients with pancytopenia associated *ith chrorjc e.xposur:. -*to benzene, one fatal, were cousins [XRsaY er of., 197221. d T h e association between benzene exposure and leukaemia is known 4 [V~CLIASaInd SAITA,I964;AKSOYet 01.. 1972bl. Recently we studied two J 4-patients with acute leukztmia in two generations following chronic exposare Y to benzene; one was recorded shortIy elsewhere ($.KSOY et a!.. 19732:. .J. .Thk study W Y supported by a grant (TACII72) from the ScierhiEc and T c c h n i d + Research Council of Tu:Lry. 2 b .a L ..-"t J a a, Rej'sratices .AKSOY, M. m d EROEV,S.: Sonx patier= in ditTcrent thalassaeniis synd:onits shouing the kttercgcncity of beta-ihd;lsjaemis genes. Ann. El. Y.A u d . Sci. 165: 13 (1969). A a o r , M.; DISCOLK.. ;A~cLzrT, .; E m o f . S., and DisCc G.: Haernatolofiial cf- fcc:s of chronic benzene ;@iswing in 217 workers. Brit. J. kdustr. Sled. 28: 196 (1971). XKSOY!.d.; DISFOLK..; EnoE\f, S.; AiicCx, T.. and D!W,OL. G.: D C ! ~ I :oSf blcod c h a c s x in 31 patients w i t h pxi;y!cmzi~.associated *ith lo~=-:crmexposure to Senreae. Brit. J. industr. \fed. 29; 56 (I9:La). XKSSY.\I.; DWOL.K.: ERDEYS,.. 3rd i h c c ~G,.:Acute lcubeir.ii duc to chronic cxpscrc to benzene. Amcr. J. \led. 51: 160 (197%). ~ A R B E R ,R. a n 3 SPIERS.P.: Oxrord silrvry o f childiiood cancc:. P r o s . Rep. 11. M.tthl.Bull. Minist. Hlrh. LAS. Scrv. 23; 46 (1964). B m u . G.E.;W A a w t , 5.: CERUOP..S.. and D I M O ~L.K.: Chromosome abnor- malitin in conrtituiional plastic anemia. S e w Engl. J. ?4d.274: 3 (1356). f l R O W > G , E.: Tolticity azd rnoraboiism of industrial S O I ~ CpAp.: ~3-.65 (E!stvier. Ainstcrdsrn 1965). G 0 ~ t - zA.; C A V I G S U L X et BERSARDJ,.: Lcs leucemia benreniqur. Bul.. Inst. nit. Sante 421 (iF6T). GOSH.3l.L.: Fami!iaf leukaznii. Acta haemat., BaKl 43: 99 (197'). CCYZ.F.W.: ?xScm, i n 1 e u i e r . i ~c!ic!cgy. Plenary Scrsicr.5 Siie~iiricCsnwib:tioiir. I Ith :n:. C%gr. h a t . . !4x21 !9X. ;!p. 4 - 5 7 (Lchmann) HEW, R.; KOLERK, .D.; RIGASD, .A.: DAHSKGE. S.; CASE. M.P.; TISDALEV.,. and MILLER,R.W.: Leukaemia acd lymphocytes in atania-t:langiecra\i3. Lancet ii: 1193 (19WMACMAHOE.Ya.nd LEW. 31.A.: Prtsa!al origin of chiIdhood teuktmia: cvidena from twint. Sew Engl. J. Mcd. 270: 1052 (1364). ..MOORHEAD,P.S.; N o w 4 P.C.: MELHA.YW, . J.; B A ~ PD.M., and ,HLWERFORD. D.A.: Chromosome preparations of leucocytcscultured from human penpberal blood. Eap. GII Res. 20: 613 (1960). R E I ~ N C I O CE.RA.:. Bcnrol poisoning: its occdrrence *nd pretention. Nat. Safely Council 1 Ith Proc. Annu. Cor.gr. Detroit; cited from b~ow.wxo1, 965. p. 2-49. Request reprints from: Prof. 51. Aasor, Internal Clinic of l r t ~ n b u l.\ledid S;hool. . ca.w, Isrunbid (Turkey)