Document 1r6KDwdvNLXkN4mwR1OB9rZd

/ - *J. B , H A F F N E R ,P R E S ID E N T J. M . B O W L B V , VIC E P R E S ID E N T K . C . B R O W N E L L , VICE P R E S ID E N T J . A . M A R T I N O , V ICE P R E S ID E N T R O B E R T L IN D L E Y 2 IE G F E L D , SE C R ETA R Y -TR EA SU R ER / S L & U ^ U U J X - / </ i l v *u/ Jj i -* * </ / 3m. A.. ^' * -'i ! --* ? / - V*' " * V i - t * - '* > k -4-20 LEXINGTON AVENUE r- 'v. v ;- / wr 1 * -- NEW YORK 1T,>T.Y. /j \ ' L Z ^ m - k -tr H '= /' M A N F R E D BOW D!TCH D IR E C T O R O F H EA LTH A N O SA F E T Y June lU, 1955 Robert A. Kehoe, M. D., D irector K ettering Laboratory of Applied Physiology University of Cincinnati College of Medicine Eden Avenue C in cinnati 19* Ohio Dear Bobs During my absence l a s t week a t th e AMA m eeting, th e enclosed fu rth e r inform ation about th e case of th e Chinese baby was received from Dr. Byers. Yrnile we are s t i l l fe e lin g our way in an e tio lo g ic a l fog, i t seems a t l e a s t to give p r e tty c le a r diagnostic evidence. I f e e l th a t I am now in a p o sitio n to pass along to Dr. Byers some o f th e comments in your good l e t t e r of May 2l;th, which I s h a ll pres e n tly do, w ith a copy to you* Sincerely, J V r 0 0 4/ ^i 98 C0 P I HAHDOLFH K* BIKES, M. * The Children* Medical Center 300 Longwood, Avenue Boston ' Jims 3 195$ Mr* Manfred Bowdlteh Lead Industries Association !i20 Lexington Avenue Host York IT , N* Y* > . Bear Manfred* ' 1 have your l e t t e r o f May 27th, and I am a fra id t h a t itd ic n n Q t occur to me to p u t a l l th e data down about th e diagnosis i n th e 'f B H ^ h i l d . Mobody knows j u s t when th e o n set of her disease was, as i t was gradual, and the p aren ts were sure i n re tro s p e c t th a t th c h ild had been poorly f o r poae weeks before they brought h e r to ua w ith c le a r-o u t symptoms of . e n c e p h a litis . In a d d itio n to e n c e p h a litis, she had anemia w ith many s tip p le d c e l l s , about as many as I have ever seen in a blood smear, co-- prop orphyrinuria, and a very high output o f le a d on Verssne. i?e got a 2l;-hour specimen when th e c h ild f i r s t cam in , a t which iH e she was c r i t i c a l l y H I* The output o f lea d then amounted only to 30 sa c ro grsjss per 2k hours, but she seemed so i l l th a t I f e l t t h a t t h i s le v e l was probably not re p re s e n ta tiv e . X th in k 'o n ly a sm all amount o f very d ilu te u rin e , having a s p e c ific g ra v ity of 1006, was excreted in th e 2k tours* The n e st day we put h er on Veraene, and she put out 3000 micro grams o f le a d and kept i t up a t th a t r a t s f o r a number of days on Ver- seno. Bach course o f Vcrsene has re s u lte d in s lig h tly lower but s t i l l very pathological outputs o f lead* I as unable to say exactly what the lev el of load in the mother's blood was* Br. BuToit's la b o ra to ry re p o rts t h a t , sp e ctro sc o p ica lly , the mother's ^ blood load in a t the upper lim its o f normal, and I have not been able to * g e t the to give rac say q u a n tita tiv e statem ent about it* The fa th e r i s a student and u su a lly e a ts a t horns, and he also does much o f h is working there too. I s t i l l have a fe e lin g th a t somewhere th e o r ie n ta ls a re holding out on ua and th a t t h i s baby has received m edication o f which we a re not aware, but I d o n 't know how to g e t a t i t any more thoroughly a t th i3 t i c . The fam ily, who a t f i r s t were q u ite ready to take, th e c h ild o u t of th e h o sp ita l to a w itch d o c to r, have I think become q u ite fond o f us l a t e l y and maybe in tin e we w ill g e t th e answer. Bone changes by x -ra y were dubious* Sincerely yours, / s / dandy K ir 0 0 1 4 7 9 9 Randolph K* Byers, M. D. To: From: LEAD INDUSTRIES ASSOCIATION 420 LEXINGTON AVENUE NEW YORK 17, N. Y. Dr. Kehoe Manfred Bowditch F urther on th e Chinese baby. \ K f 0014800