Document 1gvV6XerRnwL5o75GDEMdpO95

Komarov* AA. Markova T.F. Gigiena truda i protaationalnye xaboievamja. Mo(leva. USSR Fob. 1976. p.8-12.11 rof. (In Russian) Result* of occupational health ttudies in 580 research workeri employing puUed-power or continuous-power lasers of various wavelengths in the in frared. optical and ultraviolet ranges. Neurological examination* showed in creased fatigue at the end of the woritshift and symptoms of autonomic as thenia in 30% of them. As there were no pathological nervous or cardiovascu lar symptom* the disorders were attributed to neurodynamic changes of the higher autonomic centres responsible for homeostasis. These disorders arise out of a combination of harmful factors (noise, radiofrequency radiation. osme.etcJ in which laser radiation play* an important part toe7Sil CIS 77-406 Occupational medicine and microwave* - Personnel working In the radiation field of a radar aerial (La mAdecine du travail at lee ondee AlectromagnAtique* hyperfrAquences - A propos du personnel travaiHent dans !e champ d'Amission d'un "aArien radar"). Saunier G. UniveraltA da Bordeaux It UnitAt d'enaeignement at de recherche des sciences mAdteale*. Bordeaux. France. 1976.210p. Ulus. 169 ref. (In French) This MO thesis examines the value of clinical and biochemical criteria in the surveillance of personnel exposed to microwave radiation from a radar anten na. and the safety standards in force in the French army, and sets out to de- tannine whether these regulations should be extended to civilians working in the proximity of such emitters. Contents: technical notes on radar and its am ission; effects of microwaves on man (thermal and specific effects according to American. Russian and French observations); French end other standards and regulations: workplace studies to determine the efficadty of medical su pervision and preventive measures; review of the various types of emitter* other than mlitary. with their hazards and conditions of use. ceaecr 120 TOXIC AND DANGEROUS SUBSTANCES CIS 77*416 Petroleum hydrocarbon toxicity studies. IX, X. XI, XII, XIII. Animal end human response to vapors of "86 Thinner", "SO Thinner", Deodorised Kerosene, "40 Thinner", end Toluene Con centrate. Carpenter C.P- Kinkeed E.R Geary D.L, Myers R.C., Nachreiner DJ, SuMiven U, King J.M. Toxicology and Applied Pharmacology, New York, USA. Jww 1976. VoL36. No3. p.409-490.62 ref. (In English) Tlia 6 types of advants studied are commercial mixtures of aliphatic, cydoalh phatic end aromatic hydrocarbons. Suggested "hygienic" standards for inha lation of "80 Thinner" KUSmo/l or lOOppm). "GO Thinner" (1.7mg/l or 430ppm). Deodorized Kerosene fa. IOmg/1 or 14ppm), "40 Thinner" !0.15mg/l or 2Gppml, end Toluene Concentrate (1.9mg/l or 480ppm) ere given. Detailed reedta of human and animal experiment* support the recommended values. . <i, (oeem CIS77-411 The dose dependant pharmacokinetic profile of 2,4,5triohlorophenaxyaoetic odd following Intravenous administration torafe. Seuerhoff M.W.. BraunW.H, Blau 6JLGehring PJ. Toxicology and AppliedPharmacology. NewYork. USA, June 1978. VoL36, No3, p.491-501. Gref.OnEngfieh) Cfearano* tetea from plasma, tissue distribution, metabolism and excretion routs* and rate* of 2.4.5-trichlorophenoxyacetic add (2.4.6-T) were studied after single 5 or lOOm^kg do***. About 96% of the smaller dose of 2.4.5-T wo* excreted In the urine: about 86% of the larger dose we* excreted. The distribution was also markedly altered; the tietua/plssma ratio* for brain, fat and muscle warn simiar for both doses, but the liver and kidney ratios were significantly different The statistics! protection of experimental results with large does* to predict exposure hatsrds of email amount* is not justified be cause the capability of the body to handle the compound is altered. 0M121 CIS 77-412 Chronic toxiooiogic investigations of phoealone in the and ret Gallo MX Toxicology end Applied Pharmacology. New York. June 1976, Vd36, NoJ. p.561-668.5 ref. (in English) Phosatone was fed to rats *t 25,60 snd 2E0ppm snd to dogs at 100,200 and lOOQppm. There wea a dose-dependent inhibition of red Wood cells sod plas ma endinastarase with an extrapolated level cl no observable effect at 26ppm. Long-term exposure (2 years) shows * low order of toxicity for these animal*. town: CIS 77-413 Some neurotoxic properties of triethyien* glycol dinltrate: A comparison with decamethonium. Andersen M.E., Koppenhaver RE, Jenkins l_J. Toxicology and Applied Pharmacology, New York. USA June 1976. VoL36. No3. p.585-594.19 ref. (In English) Triethylene glycol dinitrate (TEGDN) and decamethonium (DM) caused severe tremors end chronic convulsions in rats snd in vitro both selectively blocked nerve stimulated contractions of the cholinergic rat phrenic nerve diaphragm (PND) preparation. DM was 60 times more potent than TEGDN. though the LDeo of TEGDN is 720 times that of DM. When TEGDN and DM were applied to PND preparations in combination, the inhibition of the force of contraction occurred more rapidly and was greater than expected from either compound alone. The compounds act at the sente site in vivo in the peripheral nervous system to block cholinergic tran6mis*n>\ naswi CIS 77-414 Some carbamates, tMecaibamatas ami rerheridee Bates R.R, Bcyland L. Van Each GJH Hathway D.L Ujinsky W.. Mohr U, Mur phy S.D* Okulov v.B.. Ramel C., Teichman B,, Tenecini 8. IARC monographs on the evaluation of carcinogenic risk of chemicals to man, VoLIZ Interna tional Agency for Research on Cancer, 150 Cours Albert-Thomas, 69372 Lyon Cedex 2. France. 1976.282p. Ulus. 775 ref. Price: SF.34.00. (In English) A aerie* of 24 monographs consisting of data reviewed and evaluated by an international group of experts (Lyon. 9-15 June 1976). Individual mono graphs are devoted to: carbaryl; chloropropham; disllate; dimethylcarbamoyl chloride; disulfiram; dulcin; ethyl seienac; ethyl teUurac: ferbam; ladate; msn- eb; methyl carbamate: methyl salenao; monuron: phenicarbaride; potassium bis(2-hydroxyethyl)dithiocarbamate; propham; n-propyi carbamate: semiesr- bezide (hydrochloride); sodium diethyiditiuocafbamate; thiram; zectren: zin- eb; ziram. Supplementary corrigenda and a substance cumulative index to IARC monographs (Volumes 1 -12) are appended. 06822) CIS 77-416 Determination of load in biological fluids by anodic stripping voltametry (La determinations del piombo nei liquidi biologici mediants voltametria di strippaggio anodico). Gagliano-Candela R, Napoli EL Gagliardi T. Lavoro umano. Napoli. Italy, May 1976, VoL28, NoJ. p.82-88.10 ref. (In Italian) Anodic stripping voitsmetry is compared with the dithizone method for deter mination of lead in blood end urine. The former ha* the following advantages: smaller quantity of urine X3ml) or blood KXImD necessary; more rapid HOmin at moat); cheaper; more accurate; safer for operators, since the harm ful reagent* employed in the dithizone method are not necessary. toe23l CIS 77-416 Fete of t14C) vinyl chloride following inhalation expo sure in rats. Watanabe P.G.. McGowan G.R, Madrid E.0* Gehring PJ. Toxi cology and Applied Pharmacology, New York, USA July 1976. Vol.37, No.1. p.49-60. Illua. 13 ref. (In English) Rets were exposed to 10 or I.OOOppm [140 VC for 6h. With the lOppm dose, 68V* was excreted in the urine and 2*1* in the expired air, with the IJXOppm dose 56% and 12% respectively. The kinetics of pulmonary excretion of VC it self ware linear with both doses (half-lives 20.4 and 22.4min respectively). Urinary elimination of ,4C activity followed a biphaaic pattern: hatf-hves for the mitiai linear phase were 4.6 and 4.1h respectively. 14 and 15%. respec- tivaly, of the ,4C activity remained in the carcase after 72h, No VC was found in the tissue*. N-Acetyl-S-12-hydroxyeihyDcy*teine. thiodiglycoiic add. and a third unidentified metabolite were detected in the urine. Their proportions were not effected by the size of the dose, whereas the fate of l14C) VC gener- sUywssdose-dependent K462P CIS 77-417 The pathology of vinyl chloride exposed mice. Holmberg B- Kronevi T., Winell M. Acta Vetarinaria Scandinavka, Kebenhavn, Den mark, 1976. VoL17.pJ28-342.inua.25 ref. (In English) Mice were exposed to GO and GOOppm vinyl chloride by inhalation for 52 and , 26 weeks respectively. 100% of the GOOppm group and 71% of the GOppm group developed tumours (histologically benign alveolar lung adenomas, hae- mangiosarcoma* in fat tissue, various benign end malignant tumours). Only one (GOOppm) developed haemangioMrcoma of the Kver. The frequency, num ber of fed. and size of tumours suggested a dosa-dapandent effect The role of fet tissue end of blood vessel involvement is dtacueaed. (oaezai . CIS 77-418 The significance of Sevesc: checkmate in the protec tion of workers' life and health III signifietto di Seveso: scacco matto alls tuteta della salute a deH'integrife fiaica dal lavoratori). Penza E. Quademi del "Notizario SIAS", N.l. Edizioni del Patronato SIAS. Piazza B. CairoN. Roma, Italy. 1976.24p. 14 ref. (In Italian) This booklet point* out the lesson to be learnt from catastrophes such bs the Seveso disaster, end from the hazards to which workers are exposed in work ing with dangerous substances, namely more stringent enforcement of the law and summation of certain loopholes in the legislation as it stands (laxity in observance of statutory provisions, obscure or ambiguous law, lack of proper legal protection of the rural population as regards occupational accidents snd disease*). A critical review of present Italian legislation concerning in-plant medical services and the duties of the plant physician (reference to the func tions of occupational health service* set out in ILO Recommendation No.112) is followed by comment* on the Federal German Act of 12 Dec. 1973 on the subject which the author gives aa an example to be followed, emphasising the necessity for the collaboration of workers snd workers' organisations in the flak) of occupational safety and health (Article 9 of the 1970 Italian Work er's Statute). (06626) CIS 77-419 Continuous monitoring of vinyl chloride monomer with an instrument using a paper tape impregnated with a reactant (DAtaction an continu du chiorure de vinyls monomAre *u moyen d'un appareil fonctionnant evec une bande de pepier imprAgnAe d'un rAactif). Miller R.W.. Kriesel R.S., Denenberg BA Traduction INRS 29 B-76, lnstitut national de recherche et de aAcuritA, 30 rue Oiivier-Noyer, 75680 Peris Cedex 14. France. 1976. 26pl Hlus. (In French) Translation of: Vinyl chloride monomer - A continuous monitor based upon impregnated paper tape. National Safety News, Chicago, USA, Aw 1975 V" If r " ' ' "I 6A CUSAROSS 02569