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H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
___________________ ________ ________________________DuPont-6554
TRADE SECRET
Study Title H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Volume 3 of 4
Laboratory Project ID: DuPont-6554
Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998)
y Author: Don A. Delker, Ph.D
Study Completed on: April 22,2002
Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050
Work Request Number:
Service Code NuMBER:UflB{
Clinical Pathology Study Number:
]
Page 485 of 1022
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SC A C B 1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIX C INDIVIDUAL BODY WEIGHTS
486
Sanitized!. Does not contain TSCA CBt
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL BODY WEIGHTS
Study Design
EXPLANATORY NOTES
Group Male Female Dosage________ Test Substance
I n 0 mg/kg/day Vehicle control
III IV 60 mg/kg/day Isopropanol control V VI 10 mg/kg/day H-24678 VII VIII 60 mg/kg/day H-24678 IX X 300 mg/kg/day H-24678
Critical Dates
Day 90 > Last day of test substance administration for male and female rats designated for the one-month and 3-month recovery periods.
Day 91 > Last day of test substance administration for male rats designated for the 90-day exposure period.
> Recovery period begins for rats designated for the one-month and 3-month recovery periods.
Day 92 > Last day of test substance administration for female rats designated for the 90-day exposure period.
> Male rats designated for the 90-day exposure period were sacrificed.
> Male rats dosed with isopropanol (Group III) were sacrificed.
Day 93 > Female rats designated for the 90-day exposure period were sacrificed.
> Female rats dosed with isopropanol (Group IV) were sacrificed.
Day 122 > Male and female rats designated for the one-month recovery period were sacrificed.
Day 183 > Male and female rats designated for the 3-month recovery period were sacrificed.
Note Unless footnoted, absent data indicates animal was not alive at the time of data collection.
487
.Company Sanitised. Does not contain TSCA CB1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weight!
Body Weight Body Weight Body Weight Body Weight Body Weight
ggggg
Day 0
Day 7
Day 15
Day 21
Day 28
Male, i - 0 mg/kg/day
648225 648247 648307 648294 648315 648256 648255 648246 648238 648220 648298 648228 648297 648219 648226 648222 648250 648271 648260 648264 648233 648311 648257 648278 648216
260.9 265.8 246.6 280.8 285.2 237.8 260.0 276.5 239.7 271.5 251.0 212.0 268.0 225.7 250.0 243.5 236.2 245.5 263.1 272.7 260.3 232.9 280.3 249.2 251.4
316.6 315.8 304.2 339.3 344.7 292.6 316.8 333.5 299.5 330.5 292.6 244.7 311.8 269.4 289.4 298.7 294.7 305.7 326.4 332.0 319.1 294.3 340.5 306.3 292.8
345.1 366.6 357.2 386.2 385.2 347.0 375.2 390.6 359.0 391.4 333.4 293.0 367.3 307.6 328.9 343.5 347.3 361.5 385.0 393.3 377.5 351.8 392.1 360.3 337.6
380.6 400.9 384.1 416.2 405.6 382.7 413.2 417.0 392.7 431.1 361.9 323.8 397.2 329.3 362.4 385.4 388.6 409.4 422.9 433.0 426.4 381.6 430.6 392.7 367.4
411.7 427.4 420.4 445.6 435.9 414.0 449.9 450.4 422.4 470.7 388.8 346.2 431.9 352.8 395.4 422.0 428.6 442.9 451.1 454.7 463.2 406.6 460.2 434.6 392.8
488
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
gggg
Day 35
Day 42
Day 49
Day 56
433.1 435.6 446.8 466.2 451.3 439.0 488.5 470.4 460.0 501.0 395.6 362.8 461.4 376.7 429.4 452.5 463.3 476.5 485.2 472.5 487.2 437.1 494.9 466.4 419.5
446.6 447.2 471.3
472.1 461.8 501.7 477.9 474.3 516.7 408.8 382.6 476.0 386.1 452.9 470.1 488.9 502.3 504.1 503.2 513.3 452.6 518.7 484.3 428.0
474.8 479.5 484.7
480.2 482.2 528.4 503.8 495.6 539.3 429.1 403.6 494.4 400.1 476.2 502.3 511.9 521.3 534.4 517.2 540.3 473.1 540.1 518.7 448.3
501.6 495.9 510.8
493.9 498.0 550.9 520.1 525.9 567.2 440.0 419.1 507.5 410.4 501.4 522.3 538.4 540.1 549.6 546.5 559.0 503.5 558.1 541.9 464.8
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H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body weight
ggg gg
Day 63
Day 70
Day 77
Day 84
Day 91
Male, I - 0 mg/kg/day
648225 648247 648307 648294 648315 648256 648255 648246 648238 648220 648298 648228 648297 648219 648226 648222 648250 648271 648260 648264 648233 648311 648257 648278 648216
526.0 512.3 511.0
506.8 518.5 565.2 538.1 544.9 579.0 444.8 318.6 527.6 418.4 511.9 544.5 557.0 554.9 572.5 554.2 564.4 503.0 565.3 567.1 470.4
533.5 526.6 530.7
526.7 535.0 585.2 545.6 571.0 610.7 458.3 383.9 533.1 427.6 517.9 550.9 577.4 561.4 592.9 565.5 580.5 523.5 592.6 588.0 477.5
537.1 539.8 541.0
529.7 549.5 595.9 560.4 572.6 612.8 476.1 424.9 553.3 437.4 531.6 567.9 593.5 580.6 612.9 574.2 586.9 535.3 606.2 596.6 492.2
547.8 550.3 541.3
547.1 562.9 601.0 570.3 580.1 631.2 488.5 436.2 550.1 415.3 534.6 576.5 590.5 589.5 637.7 585.5 601.2 539.9 620.3 594.3 492.8
561.5 566.7 556.5
559.4 577.6 612.0 588.0 594.4 647.0 485.0 448.1 557.3 443.1 534.0 583.1 605.7 598.5 641.2 587.9 598.4 543.3 631.8 606.8 498.1
489
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
gg gg
Day 98
Day 105
Day 113
Day 119
502.4 427.9 568.5 445.8 539.6 581.0 608.1 583.6 662.2 595.2 608.1 538.9 651.4 616.7 501.2
513.8 447.9 580.8 466.1 554.7 589.7 623.5 592.1 672.5 606.7 624.0 547.6 662.9 632.4 512.8
521.5 388.2 598.3 474.5 566.8 594.3 636.6 602.4 692.9 616.4 647.6 565.3 668.4 633.4 516.5
533.1 429.7 602.3 480.8 572.9 598.2 645.7 614.3 693.3 611.4 647.1 573.6 690.0 651.7 519.8
Company Sanitized. Dass not contain iSCA C
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______________________________________________________________________________
DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
ggggggggg
Day 126
Day 133
Day 140
Day 147
Day 154
Day 161
Day 168
Day 175
Day 182
Male, I - 0 mg/kg/day
648225 648247 648307 648294 648315 648256 648255 648246 648238 648220 648298 648228 648297 648219 648226 648222 648250 648271 648260 648264 648233 648311 648257 648278 648216
538.2 446.5 613.4 481.7 577.8
537.4 472.8 629.1 490.0 586.0
544.8 485.4 630.2 490.5 588.6
542.8 497.7 632.9 488.4 585.9
553.1 503.9 640.1 494.1 598.3
559.0 509.7 653.5 514.0 597.7
558.3 510.4 651.3 508.0 603.9
566.5 519.3 674.1 522.5 613.6
570.3 522.6 675.9 534.8 620.6
490
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H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats________ ___ _______________
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DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight
g gg
uay u
Day 7
Day 15
Male, :III - 60 mg/kg/day Isopropanol
Body Weight
g Day 21
Body Weight
g
Day 28
Body Weight
g
Day 35
Body Weight
g
Day 42
Body Weight
g Day 49
Body Weig!
g
Day 56
648302 648274 648227 648299 648303 648269 648252 648290 648258 648232
249.4 260.2 267.8 286.7 277.4 247.2 251.9 270.5 246.8 271.5
299.6 324.1 334.7 339.1 338.7 302.8 303.4 336.9 309.7 337.0
360.7 383.3 384.8 384.7 391.2 357.5 340.6 400.8 369.0 403.9
395.6 421.4 423.2 424.1 422.6 393.2 367.4 436.6 407.7 444.4
431.5 457.1 458.0 462.5 451.7 417.5 385.6 473.1 432.6 470.8
455.2 489.9 489.4 487.3 476.3 447.7 401.2 504.4 463.0 517.4
469.8 508.1 503.5 496.9 480.2 446.9 409.0 512.3 476.9 514.5
493.4 540.0 530.0 514.7 503.3 482.1 428.1 532.2 504.3 541.7
516.9 560.0 549.7 533.6 522.4 504.0 443.3 554.9 533.2 566.5
491
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight
gggg g
Day 63
Day 70
Day 77
Day 84
Day 91
Male, :III - 60 mg/kg/day Isopropanol
648302 648274 648227 648299 648303 648269 648252 648290 648258 648232
540.0 581.0 569.0 555.1 535.8 514.9 452.6 569.7 553.4 575.5
558.9 600.4 589.5 571.3 551.4 536.4 471.0 589.5 566.3 600.9
562.2 605.7 597.7 582.5 554.7 539.6 473.7 600.6 581.8 609.6
581.1 620.1 611.5 588.2 563.3 538.9 484.3 605.1 592.1 625.7
591.1 606.4 606.5 592.7 563.9 563.1 486.5 628.2 609.1 644.1
492
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DuPont-6554
Body Weight Body Weight Body Weight Body Weight
g3 gg
Day 98
Day 105
Day 113
Day 119
Company Sanitized. Does not contain TSCA CBt
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Body Weights
Body Weight Body Weight
gg
Day 0
Day 7
Male, V - 10 mg/kg/day
Body Weight
g
Day 15
Body Weight
g
Day 21
Body Weight
g
Day 28 '
Body Weight
g
Day 35
Body Weight
g
Day 42
Body Weight
g
Day 49
Body Weight
g
Day 56
648288 648286 648309 648312 648221 648273 648245 648301 648224 648283 648254 648310 648265 648253 648313
249.3 266.2 261.4 288.9 258.1 244.0 256.3 247.1 254.7 258.0 213.6 265.6 230.7 254.1 293.2
307.4 333.7 326.6 345.3 324.8 304.2 317.6 297.2 311.9 303.8 254.2 311.4 279.0 301.1 354.1
345.2 389.1 375.7 411.0 378.2 354.0 364.4 350.2 360.9 347.6 309.4 360.2 333.2 350.9 420.0
372.0 442.2 413.8 453.3 440.3 389.8 400.8 379.3 400.8 382.3 337.8 399.3 377.2 384.6 456.8
404.1 478.7 444.2 482.6 487.3 415.9 423.6 412.9 437.5 404.5 372.4 431.2 398.9 418.4 501.4
428.4 517.7 465.1 520.9 520.0 456.8 450.8 444.4 461.1 425.5 398.2 462.1 431.0 448.2 537.9
437.7 539.9 494.5 526.6 524.6 467.1 465.3 463.6 466.0 449.4 429.0 489.4 447.1 459.3 540.9
454.9 562.1 508.9 534.1 552.5 485.5 474.1 481.0 485.8 463.3 447.4 502.0 474.8 476.9 560.8
460.4 580.0 533.2 561.6 583.1 511.3 488.2 504.6 508.5 486.8 470.3 522.7 496.1 504.7 590.8
493
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H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
)
DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body weight Body Weight Body Weight Body Weight Body Weight Body Weight
ggggggggg
Day 63
Day 70
Day 77
Day 84
' 91
Day 98
Day 105
Day 113
Day 119
Male, V - 10 mg/kg/day
648288 648286 648309 648312 648221 648273 648245 648301 648224 648283 648254 648310 648265 648253 648313
473.0 614.5 541.8 586.9 594.4 520.8 527.1 521.8 525.8 495.5 481.9 523.0 509.4 523.3 612.1
482.7 627.4 553.5 594.1 607.5 535.6 535.3 534.1 538.9 504.1 489.0 538.1 524.4 534.3 622.5
490.8 638.8 571.3 612.3 624.0 558.6 556.1 544.1 552.1 509.1 498.9 551.0 536.1 545.4 642.9
496.5 643.6 581.6 623.4 640.0 554.8 573.6 556.6 558.7 450.1 498.9 561.4 546.1 556.6 665.7
502.4 650.3 581.9 629.4 642.1 575.2 583.9 563.3 573.1 462.6 508.1 562.6 550.9 564.7 668.9
475.6 503.0 561.7 544.7 570.6
499.4 509.1 577.0 557.2 577.7
519.9 523.3 588.6 570.5 592.1
533.6 521.3 595.0 569.7 607.8
494
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H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
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DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
g g g gggggg
Day 126
Day 133
Day 140
Day 147
Day 154
Day 161
Day 168
Day 175
Day 182
Male, V - 10 mg/kg/day
648288 648286 648309 648312 648221 648273 648245 648301 648224 648283 648254 648310 648265 648253 648313
546.0 529.7 595.3 574.8 605.8
559.6 541.4 593.9 585.8 626.7
568.5 545.5 611.4 600.1 633.7
564.8 547.9 614.6 596.3 634.9
566.8 539.8 631.5 598.8 654.9
565.8 542.6 635.3 608.6 655.1
567.7 539.5 630.7 614.1 661.2
583.1 546.9 636.3 624.5 668.3
585.5 550.6 646.9 630.0 683.3
495
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H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
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DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
ggggggggg
Day 0
Day 7
Day 15
Day 21
Day 28
Day 35
Day 42
Day 49
Day 56
Male, VII - 60 mg/kg/day
648300 648305 648280 648259 648223 648270 648237 648266 648243 648244 648279 648296 648314 648285 648268
238.2 275.6 259.8 288.2 285.9 240.0 268.9 272.6 253.5 248.5 261.6 229.4 259.8 218.1 255.8
277.6 333.6 316.3 346.6 346.2 293.4 327.3 331.5 307.5 301.7 300.9 262.7 303.8 264.1 314.4
315.9 390.9 381.0 396.5 401.6 354.6 394.9 386.9 352.4 347.1 349.4 306.4 349.9 311.5 367.6
340.1 429.9 428.6 425.1 448.2 377.6 430.4 417.7 382.7 379.4 375.3 344.0 376.7 346.0 403.8
360.6 466.1 453.5 465.0 489.8 408.0 472.8 464.1 418.4 397.2 406.7 361.1 397.7 360.2 446.5
382.0 500.5 480.1 495.0 524.8 441.3 515.3 497.0 443.5 429.7 433.3 378.9 420.7 383.6 480.5
387.7 496.6 497.7 502.5 534.6 450.8 524.7 497.0 461.6 432.9 444.6 396.8 425.8 393.1 493.3
400.3 510.0 502.9 517.7 563.6 467.4 557.0 531.5 497.3 461.0 457.7 423.3 433.3 415.0 507.7
419.9 531.5 517.2 534.2 598.9 490.5 578.1 556.4 516.6 482.5 465.9 450.5 456.2 433.9 523.0
496
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H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____________
)
)
_________________ DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
ggggggggg
Day 63
Day 70
Day 77
Day 84
Day 91
Day 98
Day 105
Day 113
Day 119
Male, VII - 60 mg/kg/day
648300 648305 648280 648259 648223 648270 648237 648266 648243 648244 648279 648296 648314 648285 648268
427.1 558.5 537.3 550.9 621.2 508.6 603.3 581.6 539.1 504.9 473.0 456.7 466.6 431.6 544.0
437.9 567.1 556.8 558.2 639.3 511.2 615.8 601.8 550.5 515.4 488.4 475.9 457.8 441.4 558.1
445.2 586.0 556.3 569.5 653.3 524.7 630.6 617.0 566.8 515.7 500.2 488.4 465.8 454.9 573.7
448.5 597.2 572.9 567.9 668.3 529.3 645.0 629.3 569.5 523.4 502.7 474.3 457.6 455.4 570.2
458.6 599.0 558.7 575.4 661.8 528.2 652.0 635.8 583.2 531.4 505.4 486.4 463.4 461.1 587.7
509.2 499.5 456.0 470.5 593.8
518.7 517.0 467.2 476.8 606.2
528.9 533.9 464.2 468.9 621.8
535.1 543.4 460.7 481.6 627.8
497
Company Sanitized, Does not contain TSCA GB1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body weight Body Weight Body Weight Body Weight
gg gg g gg g g
Day 126
Day 133
Day 140
Day 147
Day 154
Day 161
Day 168
Day 175
Day 182
Male, VII - 60 mg/kg/day
648300 648305 648280 648259 648223 648270 648237 648266 648243 648244 648279 648296 648314 648285 648268
527.1 525.8 465.8 490.2 588.5
552.4 565.0 487.8 500.0 644.7
563.1 578.8 490.0 511.4 670.2
570.5 587.6 494.1 512.5 679.9
585.6 600.1 506.9 517.3 693.2
597.1 622.4 511.7 516.9 703.6
597.5 626.6 517.8 525.7 714.7
605.1 642.0 521.8 526.8 733.1
608.2 .647.8 540.0 529.8 738.1
498
Company Sanitized. Does not contain TSC CBS
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H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____
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Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight
g gg gg
Day 0
Day 7
Day 15
Day 21
Day 28
Male, IX: - 300 mg/kg/day
648236 648217 648248 648218 648239 648293 648275 648308 648235 648289 648292 648272 648234 648240 648287 648277 648261 648306 648241 648284 648282 648231 648262 648230 648249
253.6 290.7 254.0 282.2 281.6 234.3 253.3 278.1 252.1 272.3 245.7 218.5 263.8 230.0 244.1 253.7 248.3 259.4 262.7 229.5 243.5 261.7 251.3 249.4 260.7
304.0 359.1 298.3 332.9 345.0 286.4 307.6 331.8 301.7 336.3 286.2 273.4 311.0 263.8 300.7 282.3 307.9 315.0 319.1 281.3 291.7 302.3 307.2 293.7 306.6
352.5 383.4 342.0 374.7 401.0 332.9 350.1 382.4 347.7 403.4 333.8 316.3 350.2 300.0 344.5 333.6 361.8 377.2 382.5 327.9 333.7 333.5 356.8 336.4 340.4
384.1 453.6 366.9 408.4 438.9 357.8 368.4 415.9 380.2 438.6 370.3 341.8 383.8 325.9 379.0 360.2 395.6 409.4 408.5 350.2 359.6 355.0 378.7 378.7 372.5
407.9 495.3 389.2 438.1 477.4 381.6 380.0 455.8 422.8 473.5 411.7 367.8 426.2 354.4 406.9 398.4 428.5 437.7 453.3 381.3 390.4 385.5 406.2 414.6 392.2
499
)
DuPont-6554
Body Weight Body Weight Body Weight Body weight
gggg
Day 35
Day 42
Day 49
Day 55
420.6 506.8 416.5 465.3 511.3 400.0 395.9 487.5 456.5 518.4 438.3 391.9 457.0 390.2 424.0 427.9 461.2 474.3 475.0 401.8 415.3 410.9 433.9 433.8 413.0
439.5 505.3 421.8 460.8 521.6 398.8 395.8 484.9 447.1 529.5 453.3 398.9 459.7 398.0 437.0 456.9 463.6 491.2 492.6 407.9 427.3 418.9 445.6 450.7 430.3
451.7 497.4 439.7 486.8 537.0 414.9 412.0 508.6 465.9 558.3 470.4 415.2 482.7 417.0 461.8 468.8 486.3 502.2 513.7 425.4 445.0 441.9 460.4 467.4 444.0
464.3 518.4 455.5 507.7 569.2 418.0 431.4 524.2 496.6 582.8 487.2 433.7 507.6 440.7 475.1 484.9 508.3 518.2 542.6 442.9 454.6 463.0 478.2 492.7 458.1
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight
ggggg
Day 63
Day 70
Day 77
Day 84
Day 91
Male, IX - 300 mg/kg/day
648236 648217 648248 648218 648239 648293 648275 648308 648235 648289 648292 648272 648234 648240 648287 648277 648261 648306 648241 648284 648282 648231 648262 648230 648249
476.2 485.7 459.8 525.5 593.3 442.6 429.5 538.0 518.4 598.2 489.3 438.1 514.1 447.6 491.0 489.4 515.4 532.7 556.5 454.7 467.1
494.0 502.4 467.9
491.0 510.8 468.0 541.3 615.8 453.3 446.6 558.7 515.6 622.5 490.9 449.2 534.0 463.3 503.7 502.7 530.7 547.8 580.2 474.6 482.8
515.9 514.4 486.0
503.5 536.7 472.4 550.5 622.8 461.9 451.7 575.1 531.9 629.5 509.4 455.3 548.7 476.7 513.7 513.0 537.3 549.5 591.0 480.7 498.7
520.3 516.1 493.4
511.3 555.0 479.3 568.5 637.5 464.3 460.9 573.4 545.7 639.0 515.3 460.6 550.0 467.2 503.4 521.8 546.3 572.9 599.9 483.5 502.3
523.4 527.6 503.4
517.5 577.1 489.5 572.5 656.7 476.7 461.7 589.4 551.9 635.7 520.9 466.1 551.5 466.9 524.9 517.7 539.5 576.5 606.7 493.6 508.0
519.2 527.3 513.6
500
)
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
gggg
' 98
Day 105
Day 113
Day 119
528.4 445.3 553.0 480.1 537.8 534.8 558.7 590.5 635.5 509.5 522.1
529.8 549.4 527.5
552.1 454.4 568.6 493.9 555.9 555.1 588.1 614.4 650.8 527.6 529.0
534.2 578.0 542.6
560.9 481.9 592.0 504.6 577.1 585.3 598.5 634.2 662.1 548.9 552.8
554.3 602.6 552.8
560.9 487.0 603.9 514.0 581.7 595.0 613.3 647.4 669.9 560.4 556.9
559.7 606.5 556.4
Company Sanitized. Doss no! contain TSCA CBf
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
gg gg g gg g g
Day 126
Day 133
Day 140
Day 147
Day 154
Day 161
Day 168
Day 175
Day 182
Male, IX - 300 mg/kg/day
648236 648217 648248 648218 648239 648293 648275 648308 648235 648289 648292 648272 648234 648240 648287 648277 648261 648306 648241 648284 648282 648231 648262 648230 648249
575.7 494.3 627.0 515.9 591.1
583.4 499.3 634.0 526.4 596.6
596.4 506.2 655.1 519.8 613.1
601.3 514.0 658.2 518.1 622.7
616.0 523.1 674.4 527.5 630.9
620.8 532.6 692.7 545.0 637.7
622.5 540.0 698.3 552.9 649.5
631.8 548.2 713.7 557.2 661.2
645.2 552.6 719.6 563.0 668.2
501
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weig]
ggggg
Day 0
Day 7
Day 15
Day 21
Day 28
Female, II - 0 mg/kg/day
648421 6483,93 648436 648430 648351 648423 648353 648395 648372 648370 648356 648431 648422 648357 648405 648439 648389 648434 648425 648404 648394 648426 648346 648442 648427
203.2 201.4 203.7 202.2 197.0 197.0 195.1 190.3 186.4 178.2 175.0 174.4 189.0 202.2 171.3 198.4 162.8 180.2 209.3 195.6 187.2 229.3 192.1 218.4 198.8
225.0 220.2 237.8 215.8 220.7 212.8 210.4 208.8 204.3 196.4 204.3 203.3 208.5 217.2 183.8 238.1 185.2 196.7 250.6 208.2 208.0 263.2 204.2 249.8 231.4
250.3 242.3 262.6 242.0 241.7 251.2 235.3 226.6 221.6 222.2 218.5 218.2 218.8 240.3 205.7 256.9 205.2 214.5 283.9 231.9 232.2 281.4 231.3 291.4 263.2
270.4 260.0 276.6 248.5 252.4 254.0 244.3 234.6 249.9 227.5 232.6 227.1 239.0 254.1 215.6 291.2 213.5 245.0 297.5 253.8 245.0 299.5 239.2 299.4 281.5
287.2 270.8 283.0 266.9 258.5 268.6 261.4 247.1 256.2 246.0 239.4 229.6 245.7 260.6 226.7 302.4 215.1 267.1 319.3 267.6 261.2 322.6 255.7 333.5 292.2
502
)
DuPont-6554
Body Weight Body Weight Body Weight Body weight
gggg
Day 35
Day 42
Day 49
Day 56
304.6 274.8 286.2 267.1 273.0 286.6 282.8 249.7 273.6 258.5 250.8 249.1 265.3 278.7 238.8 295.7 233.1 281.3 333.9 269.6 261.2 349.4 263.4 352.1 297.4
310.0 275.0 297.2 276.6 274.5 291.8 273.7 262.5 270.1 263.7 260.6 261.3 268.5 286.3 242.7 311.0 243.1 281.2 348.3 285.8 281.3 367.6 284.5 357.0 304.3
317.9 283.9 304.8 281.4 295.1 306.4 286.1 268.7 293.8 274.6 259.2 268.0 290.9 297.9 248.6 318.1 248.7 295.0 355.8 291.6 288.2 378.7 285.4 371.4 316.3
327.0 288.1 314.0 293.7 286.5 313.2 295.5 276.8 311.5 280.5 271.7 277.1 293.7 306.0 264.6 342.3 254.1 298.9 362.1 300.1 291.1 399.5 299.8 387.7 321.8
Company SanWzed*0 <3t not contain TSCM QBt
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
individual Body weights
Body Weight Body Weight Body Weight Body Weight Body Weight
g Day 63
S Day 70
g Day 77
g Day 84
g Day 91
Female, II - 0 mg/kg/day
648421 648393 648436 648430 648351 648423 648353 648395 648372 648370 648356 648431 648422 648357 648405 648439 648389 648434 648425 648404 648394 648426 648346 648442 648427
331.3 298.4 310.0 308.8 300.2 315.6 305.0 272.7 309.9 283.4 271.0 278.4 291.5 301.3 257.6 329.0 254.4 305.8 373.3 293.1 292.1 414.0 289.8 400.4 333.6
348.8 301.3 325.2 306.2 298.3 326.3 309.1 287.1 321.7 285.2 281.6 292.9 298.4 310.9 257.7 347.2 266.1 313.0 384.6 305.2 304.7 412.3 300.4 403.3 331.7
353.6 313.5 330.6 310.1 304.7 333.9 322.6 291.5 333.7 289.6 279.2 293.0 302.7 315.1 262.7 336.1 264.9 326.5 380.9 311.5 307.5 417.0 297.1 413.2 341.4
362.1 332.7 348.2 320.1 315.6 330.5 320.3 291.0 340.0 300.0 274.5 297.4 301.2 319.3 275.9 354.4 259.8 329.4 387.9 303.7 315.0 420.9 302.7 421.6 349.5
359.9 321.1 335.4 318.5 313.5 336.8 327.0 280.4 360.7 300.5 272.5 296.7 307.1 319.4 273.2 353.1 270.1 323.0 398.3 300.0 310.1 415.7 296.6 419.3 342.7
503
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
gggg
' 98
Day 105
Day 113
Day 119
283.0 294.9 308.5 324.7 262.2 370.1 280.4 340.6 417.5 315.2 317.7 434.6 310.0 441.2 361.8
289.9 295.1 322.4 319.8 267.1 383.0 286.3 351.8 418.6 323.9 323.8 453.8 312.2 455.9 369.1
295.9 299.4 324.4 320.2 267.9 389.4 292.2 358.7 419.1 329.5 322.1 449.5 323.6 464.8 378.2
287.7 313.2 334.2 325.5 271.1 392.9 296.4 370.5 432.7 326.8 318.2 471.0 328.6 461.6 368.0
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body WeightE
Body Weight Body Weight Body Weight Body weight Body Weight
gg gg g
Day 126
Day 133
Day 140
Day 147
Day 154
Female, II - 0 mg/kg/day
648421 648393 648436 648430 648351 648423 648353 648395 648372 648370 648356 648431 648422 648357 648405 648439 648389 648434 648425 648404 648394 648426 648346 648442 648427
299.4 314.4 334.5 324.8 269.3
301.3 315.0 341.1 323.7 269.9
301.4 327.9 348.0 334.4 280.1
293.0 329.5 355.2 334.0 281.6
303.2 330.0 351.6 339.8 285.2
504
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
gggg
Day 161
Day 168
Day 175
Day 182
309.7 339.7 351.9 337.3 295.7
309.2 333.3 356.0 334.1 288.1
306.5 346.9 360.4 332.7 289.2
313.4 348.5 358.8 343.3 287.4
Company Sanitized. Does not contain TSCA C8I
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
ggggggggg
Day 0
Day 7
Day 15
Day 21
Day 28
Day 35
Day 42
Day 49
Day 56
Female, IV - 60 mg/kg/day Isopropanol
648396 648409 648410 648369 648397 648364 648408 648402 648424 648390
192.5 222.6 209.2 191.4 212.7 189.4 172.5 184.1 163.1 197.5
206.8 235.4 232.7 223.8 202.5 214.8 193.6 198.0 189.1 220.5
233.3 267.0 257.4 246.0 224.1 227.0 215.9 230.5 212.7 248.7
258.4 277.6 278.1 252.5 244.7 252.8 217.7 233.4 229.2 254.1
274.0 289.8 287.2 270.6 256.2 266.6 237.7 258.3 247.3 269.3
273.4 303.3 295.1 286.4 257.4 263.8 256.6 269.5 249.6 280.4
283.8 299.7 301.2 279.0 274.3 278.7 262.4 27.0.5 260.5 289.6
296.0 304.7 313.0 290.3 284.4 275.9 260.8 288.5 274.4 301.9
301.7 311.5 323.4 304.3 291.4 286.5 271.0 300.6 279.8 307.6
505
Company Sanitized, Does not contain TSC CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
ggggggggg
Day 63
Day 70
Day 77
Day 84
Day 91
Day 98
Day 105
Day 113
Day 119
Female, IV - 60 mg/kg/day Isopropanol
648396 648409 648410 648369 648397 648364 648408 648402 648424 648390
297.2 321.6 306.3 294.8 283.6 294.3 271.0 305.5 290.0 307.7
312.7 327.1 319.0 311.5 301.0 303.5 288.1 314.5 294.1 315.3
310.7 326.4 328.9 311.1 303.3 316.9 293.9 314.7 303.7 320.6
321.5 336.1 339.9 321.6 300.7 330.1 290.5 320.5 308.8 329.0
317.4 332.3 336.8 314.3 298.9 328.1 300.0 328.2 305.0 327.0
506
Company Sanitized. Does not contain TSCA CB
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual
Body Weight Body Weight Body Weight Body Weig
gggg
Day 0
Day 7
Day 15
Day 21
Female, VI - 10 mg/kg/day
648433 648406 648441 648414 648366 648382 648345 648374 648403 648429 648384 648352 648365 648413 648385
185.5 204.4 201.0 183.4 202.8 195.4 174.9 185.5 192.4 191.6 201.1 184.8 205.1 208.3 178.4
199.6 225.4 220.1 212.0 224.0 204.7 192.2 209.2 211.2 214.6 211.4 200.1 213.4 226.8 199.3
220.0 245.3 234.1 228.5 267.2 229.0 201.0 229.3 224.0 237.8 219.9 220.7 238.6 248.0 208.2
232.9 241.9 258.2 246.7 275.0 249.8 209.4 243.1 230.4 254.1 235.6 231.1 247.7 270.3 229.5
))
DuPont-6554
Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight
ggggg
Day 28
Day 35
Day 42
Day 49
Day 56
244.5 264.2 271.8 248.6 278.0 246.4 222.5 258.2 248.6 272.6 249.7 236.5 260.3 283.2 241.6
254.3 280.3 282.4 275.2 289.0 267.8 233.5 273.5 267.3 282.8 259.4 256.1 273.2 293.8 248.7
251.2 272.1 291.4 278.2 307.4 277.1 241.3 279.0 265.0 288.6 260.1 255.8 265.2 307.4 259.4
266.0 276.7 298.7 272.4 323.4 283.4 242.5 283.3 264.6 284.7 271.7 265.8 280.3 317.2 261.7
280.3 290.4 316.2 278.2 326.7 280.8 246.1 290.8 273.5 301.3 285.3 273.8 284.6 328.0 267.2
507
Company Sanitized, Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weights
Body Weight Body Weight Body weight Body Weight Body Weight
ggggg
Day 63
Day 70
Day 77
Day 84
Day 91
Female, VI - 10 mg/kg/day
648433 648406 648441 648414 648366 648382 648345 648374 648403 648429 648384 648352 648365 648413 648385
276.2 297.6 315.0 295.3 328.2 288.7 257.4 285.2 274.5 297.5 278.5 288.5 291.4 323.9 266.4
277.9 305.3 326.9 291.3 334.9 296.9 258.9 298.3 282.5 308.4 280.8 290.9 289.0 339.5 268.9
288.6 302.2 331.3 294.4 331.8 294.0 262.9 302.8 284.5 304.9 301.7 298.5 284.5 348.3 276.3
291.2 312.4 341.6 292.5 340.2 291.5 265.3 311.3 292.3 314.4 303.0 315.5 302.4 347.5 281.5
289.2 315.4 337.2 305.9 351.7 306.0 271.2 306.0 291.1 322.9 297.6 311.5 312.0 346.0 290.8
508
)
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
3ggg
' 98
Day 105
Day 113
Day 119
287.1 311.1 308.1 366.4 298.7
324.5 329.5 316.4 379.0 312.4
323.7 333.9 329.0 391.4 318.3
321.4 340.7 328.9 392.0 315.3
Company Sanitized. Does not contain TSGA ray
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Body Weights
Body weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
ggggggggg
Day 126
Day 133
Day 140
Day 147
Day 154
Day 161
Day 168
Day 175
Day 182
Female, VI - 10 mg/kg/day
648433 648406 648441 648414 648366 648382 648345 648374 648403 648429 648384 648352 648365 648413 648385
344.4 355.2 340.4 391.1 322.4
340.1 378.4 348.8 378.4 319.8
335.3 363.5 361.3 394.1 318.4
333.9 385.8 372.6 384.3 327.6
346.5 411.6 381.8 392.3 339.0
336.0 435.9 383.7 386.4 338.5
335.8
395.5 390.4 343.2
343.6
390.7 394.5 351.4
358.3
406.9 395.3 358.1
509
Company Sanitized. IS not contain TSCA m
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual
Body Weight Body Weight Body Weight Body Weig'
gggg
Day 0
Day 7
Day 15
Day 21
Female, VIII - 60 mg/kg/day
648380 648381 648432 648440 648348 648417 648368 648401 648362 648354 648349 648415 648379 648386 648360
196.7 197.3 218.7 202.5 202.0 194.0 199.5 181.4 188.0 183.2 200.9 180.0 209.2 204.5 175.0
230.0 218.6 241.9 224.4 228.8 210.4 217.3 206.4 204.7 201.7 216.8 210.0 228.9 212.1 189.9
254.4 230.7 265.0 249.7 257.6 227.4 267.7 225.9 226.9 223.0 229.0 227.1 249.3 230.9 203.4
280.4 254.5 276.5 261.8 268.4 239.9 254.8 239.8 238.2 235.4 237.9 247.1 256.8 252.9 223.7
)
DuPont-6554
Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight
0 gggg
Day 28
Day 35
Day 42
Day 49
Day 56
286.3 257.3 303.8 296.3 290.6 252.5 272.6 255.1 250.4 242.0 252.6 271.7 275.8 268.7 236.2
306.7 269.8 321.3 320.3 304.4 270.1 281.6 263.7 250.5 252.5 269.5 277.0 289.6 283.1 243.0
313.1 265.3 332.6 334.9 314.0 269.2 288.1 257.5 264.2 255.5 273.6 299.1 287.3 298.4 254.4
318.4 284.7 343.4 328.4 331.0 276.7 288.0 279.4 273.0 261.2 273.9 304.7 302.6 299.1 264.4
333.6 287.9 345.3 356.6 326.8 294.7 314.3 286.8 275.4 266.3 292.0 313.6 313.6 317.1 277.4
510
C o m pany sm m a a DoB8
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight
ggggg
Day 63
Day 70
Day 77
Day 84
Day 91
Female, VIII - 60 mg/kg/day
648330 648381 648432 648440 648348 648417 648368 648401 648362 648354 648349 648415 648379 648386 648360
345.6 288.4 359.2 352.7 347.6 294.2 336.1 286.7 271.2 260.6 298.8 320.1 314.9 320.0 268.0
347.7 293.7 368.8 355.8 351.6 299.7 309.1 286.2 285.2 272.2 299.0 322.7 310.9 324.6 280.5
359.5 288.0 379.3 374.1 352.9 303.6 307.5 296.3 290.5 270.0 294.7 326.1 323.1 333.7 286.9
356.0 303.2 404.4 378.2 352.8 319.2 314.9 306.3 294.2 276.5 304.5 326.5 331.9 335.6 291.2
358.4 306.1 406.8 399.4 353.8 316.3 311.7 308.4 288.4 270.8 316.0 333.4 332.8 341.3 285.2
511
)
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
gggg
Day 98
Day 105
Day 113
Day 119
308.9 340.3 337.4 325.9 300.1
318.8 354.7 359.2 327.8 313.6
326.3 354.8 374.3 319.4 330.8
322.1 357.8 373.6 332.3 318.1
Company Sanitized. Does not contain TSCA CBt
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Body Weights
Body Weight Body Weight Body weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight
g 9 ggggggg
Day 126
Day 133
Day 140
Day 147
Day 154?;
Day 161
Day 168
Day 175
Day 182
Female, VIII - 60 mg/kg/day
648380 648381 648432 648440 648348 648417 648368 648401 648362 648354 648349 648415 648379 648386 648360
319.8 359.7 373.0 329.3 327.2
329.3 365.4 393.5 325.3 330.0
326.3 362.7 389.9 340.4 327.4
323.1 364.8 381.4 341.0 330.7
335.8 366.0 389.2 345.1 340.8
348.5 370.4
405.0 359.1 344.1
346.4 372.5 421.0 352.3 336.1
338.1 386.0 423.8 350.5 342.3
352.6 387.5 429.8 356.5 353.8
512
Company Sanitized, Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weigi
ggggg
Day 0
Day 7
Day 15
Day 21
Day 28
Female, X - 300 mg/kg/day
648407 648392 648435 648376 648347 648412 648438 648400 648388 648373 648358 648367 648391 648411 648355 648387 648419 648378 648398 648350 648383 648359 648375 648399 648363
195.2 197.1 209.5 216.9 194.3 186.0 189.6 221.5 219.7 203.0 180.6 205.2 209.0 180.3 195.9 176.7 188.1 184.7 197.5 205.4 169.1 198.2 195.4 205.2 207.3
216.4 217.2 227.3 238.3 221.7 199.6 202.4 226.1 221.6 227.5 192.4 227.0 221.3 202.8 212.1 195.8 205.4 200.2 215.1 220.8 187.5 224.5
231.0 241.1
240.4 225.7 257.2 266.4 245.9 218.1 229.2 251.6 246.3 248.6 215.9 248.1 245.8 229.7 217.8 217.3 229.4 221.6 236.8 247.5 201.4 241.5
258.9 268.9
240.6 249.8 267.7 273.3 259.0 235.3 238.0 263.4 259.1 251.8 226.7 262.6 247.9 239.5 222.4 223.4 247.3 237.8 234.5 256.4 213.0 251.6
274.7 300.9
267.6 267.7 285.8 280.5 263.6 237.0 264.0 274.1 279.0 273.8 244.2 265.4 259.3 252.1 248.1 239.6 256.2 260.7 255.9 279.6 223.7 284.1
286.8 298.8
513
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
gggg
Day 35
Day 42
Day 49
Day 56
275.1 268.0 298.0 297.9 281.4 254.5 280.2 298.9 292.5 284.8 248.7 275.6 279.3 263.8 248.3 267.0 263.5 264.7 268.6 297.5 235.8 293.0
303.0 319.3
281.4 283.3 306.9 307.9 286.6 261.7 280.1 300.7 289.1 300.2 259.8 289.7 269.7 277.6 261.4 268.3 274.0 272.0 278.5 306.3 242.9 303.5
312.1 322.9
286.0 287.0 311.4 314.0 296.5 268.0 295.2 308.8 296.7 302.3 265.5 302.3 288.3 278.2 261.2 276.5 280.2 289.2 281.0 319.8 244.6 310.2
306.5 334.4
298.7 298.9 342.2 312.6 309.7 266.1 311.1 322.9 310.2 319.1 371.2 313.9 281.7 286.0 273.5 289.1 285.8 299.8 294.7 336.3 257.8 318.5
328.7 340.7
Company Sanitized. Does not contain TSCA CB
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight
g ggg g
Day 63
Day 70
Day 77
Day 84
Day 91
Female, X - 300 mg/kg/day
648407 648392 648435 648376 648347 648412 648438 648400 648388 648373 648358 648367 648391 648411 648355 648387 648419 648378 648398 648350 648383 648359 648375 648399 648363
300.6 304.9 342.2 332.3 314.9 276.1 314.3 313.3 320.7 328.0 273.1 314.5 292.0 293.1 275.6 294.3 289.6 303.5 301.5 334.9 261.2 339.6
328.9 339.8
306.8 313.1 356.9 341.2 323.2 284.0 323.4 337.6 325.0 331.6 282.4 322.8 298.7 294.9 276.9 303.0 300.0 301.2 314.4 354.9 268.3 346.8
342.3 361.6
308.0 306.1 361.1 341.7 322.1 279.1 326.2 336.0 324.7 327.7 282.4 327.5 307.1 298.7 282.0 295.4 301.5 310.5 313.4 352.9 268.7 349.3
350.2 357.2
316.7 307.6 380.9 344.2 323.2 280.4 335.4 336.5 334.5 340.0 291.4 322.3 301.0 299.9 281.9 312.1 303.4 316.3 318.3 354.3 277.1 356.3
341.4 358.7
323.0 317.3 389.0 356.1 336.5 288.6 337.8 347.6 342.5 345.4 276.3 333.8 314.6 305.6 284.8 303.9 301.6 313.1 310.2 358.8 270.4 342.9
345.7 369.1
514
DuPont-6554
Body Weight Body Weight Body Weight Body Weight
gggg
' 98
Day 105
Day 113
Day 119
344.6 282.7 342.8 312.2 304.5 290.4 309.8 319.1 315.0 327.4 355.0 276.0 363.6
355.1
348.6 292.7 354.0 318.6 303.7 296.4 317.0 319.6 336.6 325.2 370.3 282.3 367.6
347.5
350.1 298.4 372.1 320.0 316.0 303.0 330.1 324.9 335.4 328.2 371.7 282.7 381.2
367.4
357.4 305.2 373.2 301.8 316.4 301.1 348.4 338.7 336.8 339.6 384.2 295.7 393.3
368.4
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Body Weights
Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body weight Body Weight Body Weight
ggggg ggg g
Day 126
Day 133
Day 140
Day 147
Day 154
Day 161
Day 168
Day 175
Day 182
Female, X - 300 mg/kg/day
648407 648392 648435 648376 648347 648412 648438 648400 648388 648373 648358 648367 648391 648411 648355 648387 648419 648378 648398 648350 648383 648359 648375 648399 648363
363.0 313.5 382.1 310.6 323.0
355.1 307.0 385.6 313.4 314.8
365.6 314.7 383.8 321.6 319.9
379.4 313.9 383.5 328.3 320.9
371.2 322.3 395.5 344.1 321.5
374.9 318.6 401.8 357.3 320.8
372.3 317.7 410.5 365.9 324.1
381.7 323.0 420.5 373.7 326.5
380.1 323.1 428.1 379.3 334.6
515
C mpany Sanifeed. Does not contain TSCA C8I
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIX D INDIVIUAL FOOD CONSUMPTION
516
Company Sanitized. Does not contain TSCA C81
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FOOD CONSUMPTION
Study Design
EXPLANATORY NOTES
Group
Male Female Dosage________ Test Substance
I n 0 mg/kg/day Vehicle control m IV 60 mg/kg/day Isopropanol control
V VI 10 mg/kg/day H-24678
vn vm 60 mg/kg/day H-24678 rx X 300 mg/kg/day H-24678
Critical Dates
Day 90 > Last day of test substance administration for male and female rats designated for the one-month and 3-month recovery periods.
Day 91 > Last day of test substance administration for male rats designated for the 90-day exposure period.
> Recovery period begins for rats designated for the one-month and 3-month recovery periods.
Day 92 > Last day of test substance administration for female rats designated for the 90-day exposure period.
> Male rats designated for the 90-day exposure period were sacrificed.
> Male rats dosed with isopropanol (Group III) were sacrificed.
Day 93 > Female rats designated for the 90-day exposure period were sacrificed.
> Female rats dosed with isopropanol (Group IV) were sacrificed.
Day 122 > Male and female rats designated for the one-month recovery period were sacrificed.
Day 183 ^ Male and female rats designated for the 3-month recovery period were sacrificed.
Note Unless footnoted, absent data indicates animal was not alive at the time of data collection.
Footnotes
a On test day 84, food consumption data were not collected for 5 rats/group designated for 3-month recovery.
517
Company Sanitized. Does not contain TSCA CBI
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________
Individual Food Consumption
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 7
Day 15
Food Cons. g/anm/day
Day 21
Food Cons. g/anm/day
Day 28
Food Cons. g/anm/day
Day 35
Food Cons g/anm/day
Day 42
Male, I - 0 mg/kg/day
648225 648247 648307 648294 648315 648256 648255 648246 648238 648220 648298 648228 648297 648219 648226 648222 648250 648271 648260 648264 648233 648311 648257 648278 648216
27.3 28.6 26.3 27.9 29.1 23.5 28.8 29.2 27.8 27.8 23.4 19.3 25.9 24.7 24.0 26.9 27.4 28.9 29.6 27.0 26.0 26.1 29.4 26.2 24.8
25.3 28.9 26.9 27.5 27.1 28.1 29.6 30.3 29.1 29.3 23.4 24.3 27.5 23.6 24.5 29.1 29.2 29.4 29.9 29.6 29.6 26.8 29.2 28.7 26.4
28.5 30.0 28.1 26.6 25.5 29.1 30.7 30.3 28.6 30.8 23.5 25.4 30.0 23.0 26.6 29.3 31.2 32.4 30.9 30.2 32.9 27.5 30.4 28.7 27.3
28.5 29.4 29.4 28.4 26.3 29.4 31.3 29.1 29.3 31.6 25.4 24.4 29.5 26.5 34.6 31.2 32.3 32.5 31.4 28.7 33.1 28.0 31.2 30.7 26.7
28.9 29.0 29.5 28.0 25.7 27.9 31.4 28.6 30.6 31.7 22.3 24.7 30.6 23.5 29.2 31.2 33.7 32.3 31.5 27.1 31.1 28.5 32.0 29.8 26.0
25.4 25.5 26.6
24.7 25.5 25.0 26.4 28.2 26.9 23.8 23.7 28.2 25.0 29.2 30.7 32.3 30.1 29.7 29.4 31.5 27.3 30.3 30.3 24.2
518
DuPont-6554
Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day
Day 49
Day 56
Day 63
Day 70
31.6 31.6 29.5
25.6 31.9 31.8 31.2 32.6 32.5 25.5 25.5 30.7 25.4 30.6 33.8 33.0 33.2 29.4 28.5 31.3 28.0 33.2 32.5 26.2
33.3 31.4 29.5
26.4 29.4 30.2 30.1 32.3 31.9 24.7 25.0 28.9 22.7 30.3 30.7 35.2 31.5 30.6 30.6 29.3 30.2 30.5 32.0 26.3
32.3 30.4 27.1
26.9 29.8 28.7 30.6 31.9 32.4 23.3 10.5 29.5 23.6 29.2 31.8 33.0 31.0 31.6 27.1 28.0 26.1 28.2 31.1 24.6
28.0 29.8 28.2
27.1 30.0 29.9 28.8 32.6 32.4 23.2 17.6 27.8 23.7 26.3 29.9 34.7 30.3 34.2 29.6 29.1 28.0 31.8 30.3 24.8
Company Sanitized. Does not contain TSOA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____________________________ ____________ _______ _________________
Individual Food Consumption
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 77
Day 84
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 91
Day 98
Day 105
Day 113
Day 119
Male, I - 0 mg/kg/day
648225 648247 648307 648294 648315 648256 648255 648246 648238 648220
648298
648228
648297
648219
648226 648222 648250 648271 648260 648264 648233 648311 648257 648278 648216
26.7 31.3 27.7
27.5 29.2 28.1 28.7 31.2 30.7
24.5
28.6
29.4
21.9
27.9 31.8 34.5 30.4 34.8 27.8 27.2 27.0 31.9 29.8 26.5
28.0 31.8 25.9
28.2 29.8 27.0 27.7 30.8 31.6
a
a
a
a
a
32.9 33.5 31.6 37.9 29.1 30.0 26.7 33.6 29.1 26.0
27.9 31.6 27.2
27.9 29.9 28.2 31.3 31.5 31.3
20.4
23.1
25.7
21.6
24.1 30.0 32.9 30.3 32.4 27.4 26.6 25.6 32.6 29.3 23.7
22.8
15.8
27.4
22.2
25.5 29.1 29.9 25.4 34.4 25.4 26.0 20.5 30.9 27.0 23.1
23.5
25.6
27.6
23.0
27.5 28.7 31.1 28.4 33.3 28.8 27.6 24.3 32.1 27.1 25.4
25.1
17.9
29.5
23.0
28.2 29.7 33.5 29.6 34.5 28.5 30.6 29.9 29.7 27.4 24.9
24.4
23.6
30.2
22.8
26.9 29.6 32.5 29.5 31.2 27.7 27.4 27.5 34.2 27.7 25.6
DuPont-6554
519
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Food Consumption
Food Cons. g/anm/day
Day 7
Food Cons. g/anm/day
Day 15
Food Cons. g/anm/day
Day 21
Male, :III - 60 mg/kg/day Isopropanol
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 28
Day 35
Food Cons. g/anm/day
Day 42
Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day
Day 49
Day 56
Day 63
Day 70
648302 648274 648227 648299 648303 648269 648252 648290 648258 648232
26.2 29.0 28.7 28.3 30.1 27.7 26.4 28.8 27.8 31.7
27.3 30.2 28.6 27.8 30.6 28.3 25.8 30.0 28.9 32.1
29.5 33.7 30.5 29.6 31.2 30.0 24.3 30.2 28.7 32.4
29.6 32.3 28.7 30.5 30.5 28.9 25.3 30.6 29.1 32.1
26.9 31.5 29.7 29.5 30.7 28.9 22.7 30.1 29.7 32.7
24.1 29.6 27.2 26.4 24.3 25.7 21.1 25.2 25.9 26.7
28.3 34.9 31.7 30.3 30.4 29.6 26.3 29.7 31.6 30.3
28.6 34.7 32.2 30.4 30.6 28.0 25.5 30.8 32.5 31.8
29.2 35.2 30.3 30.4 29.1 27.9 24.7 30.5 26.4 29.9
30.0 34.7 31.5 31.5 28.9 29.0 25.1 29.8 31.8 31.6
520
Company Sanitized. B ass not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Food Consumption
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 77
Day 84
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 91
Day 98
Food Cons. g/anm/day
Day 105
Food Cons. Food Cons
g/anm/day g/anm/day
Day 113
Day 119
Male, III - 60 mg/kg/day Isopropanol
648302 648274 648227 648299 648303 648269 648252 648290 648258 648232
28.8 32.9 31.3 33.4 26.9 27.1 24.1 30.3 32.3 30.6
28.5 33.7 32.7 32.5 27.0 27.8 26.0
30.1 30.7 30.1
28.5 28.9 26.4 29.1 25.6 28.1 24.2 31.3 31.3 28.5
DuPont-6554
521
Company Sanitized. Does not contain TSCA CBf
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
)
DuPont-6554
Individual Food Consultation
Food Cons. g/anm/day
Day 7
Food Cons. g/anm/day
Day 15
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 21
Day 28
Food Cons g/anm/day
Day 35
Male, V - 10 mg/kg/day
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
' Day 42
Day 49
Day 56
Day 63
Day 70
648288 648286 648309 648312 648221 648273 648245
648301 648224 648283 648254 648310 648265 648253 648313
30.1 29.4 28.1 30.2 30.1 27.5 29.0
28.8 27.5 25.5 20.9 27.2 23.9 24.7 28.3
30.4 30.6 27.4 30.5 30.6 27.8 29.1
29.1 27.9 25.8 23.3 28.2 25.1 25.7 30.2
30.6 34.3 29.2 32.2 36.0 28.5 29.5
30.8 30.8 26.7 25.0 31.4 28.0 27.6 32.8
29.5 34.6 29.3 33.4 35.1 28.3 29.0
b
29.4 26.3 27.9 29.7 26.4 27.3 33.4
30.3 35.3 29.6 31.0 33.7 28.9 29.4
32.2 28.2 26.6 26.6 31.3 26.5 28.3 32.0
27.3 29.9 26.9 26.2 28.3 27.6 26.7
29.3 24.8 27.3 26.0 30.2 25.4 25.0 26.9
30.0 33.8 30.7 29.1 33.9 31.1 30.0
32.9
28.6 26.4 26.4 28.9 26.8 25.7 32.2
27.7 32.4 30.0 31.6 34.8 31.2 28.7
32.1 29.3 26.7 25.8 29.4 28.1 30.1 32.9
26.2 32.5 27.7 32.1 29.9 26.6 31.7
30.5 28.4 24.4 24.3 28.1 24.7 26.9 31.0
28.4 31.7 28.4 30.4 29.4 28.6 27.6
32.0 28.1 26.8 24.8 31.0 27.5 27.3 31.6
522
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Food Cons. g/anm/day
Day 77
Food Cons. Food Cons
g/anm/day g/anm/day
Day 84
Day 91
Male, V - 10 mg/kg/day
648288 648286 648309 648312 648221 648273 648245 648301 648224
648283
648254
648310
648265
648253 648313
29.6 32.0 30.0 32.4 29.9 30.9 31.3 32.0 29.0
26.3
25.9
30.8
27.5
28.1 32.5
28.0 29.2 28.1 30.0 31.2 30.1 31.4 30.7 27.0
a
a
a
a
a
34.1
26.4 28.9 27.8 27.1 28.5 28.2 30.2 27.5 28.7
18.4
22.0
25.0
22.7
24.3 29.5
Individual Food Consumption
Food Cons. Food Cons, Food Cons, Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day
Day 98
Day 105
Day 113
Day 119
23.6 22.7 24.7 24.0 23.8
26.2 22.8 28.0 24.2 26.8
28.0 24.9 29.8 25.2 28.0
30.2 23.8 28.9 23.4 27.0
DuPont-6554
523
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Food Consumption
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 7
Day 15
Day 21
Day 28
Day 35
Day 42
Male, VII - 60 mg/kg/day
648300 648305 648280 648259 648223 648270 648237 648266 648243 648244 648279 648296 648314 648285 648268
25.6 29.8 28.5 31.9 28.0 27.8 28.8 29.8 28.7 28.0 26.6 23.8 24.6 22.8 30.1
26.4 30.6 29.5 30.9 30.1 26.9 31.7 32.3 28.2 27.5 26.3 24.8 24.9 23.8 31.1
25.5 32.4 32.5 30.5 31.4 28.5 32.1 34.1 28.7 27.3 25.6 27.0 25.1 25.7 29.7
24.1 30.7 30.7 31.5 33.0 27.7 32.4 33.4 28.8 27.5 26.8 26.7 24.2 25.5 31.2
24.8 33.0 31.5 31.2 30.8 28.5 32.1 31.3 29.5 26.6 26.7 24.8 24.8 24.4 32.3
22.5 26.4 26.3 26.2 26.5 25.7 30.3 28.0 27.3 23.6 26.9 23.2 21.6 23.8 30.2
524
DuPont-6554
Food Cons. Food Cons
g/anm/day g/anm/day
Day 49
Day 56
Food Cons. Food Cons
g/anm/day g/anm/day
Day 63
Day 70
25.0 27.7 29.6 28.4 31.2 27.2 33.5 33.1 34.5 29.9 26.4 24.6 25.7 26.3 30.5
24.4 31.8 31.2 29.4 33.9 28.4 33.4 35.9 33.2 26.8 25.3 25.4 27.5 27.0 29.0
23.9 29.7 29.8 30.0 31.7 26.3 32.2 33.7 30.8 26.0 24.6 24.3 24.5 21.1 27.9
25.8 29.9 29.4 29.2 33.0 27.0 32.6 33.4 30.1 27.3 27.4 25.8 20.7 22.0 28.8
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________________________________________ ______ ________
Individual Food Consumption
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons
g/arm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 77
Day 84
Day 91
Day 98
Day 105
Day 113
Day 119
Male, VII - 60 mg/kg/day
648300 648305 648280 648259 648223 648270 648237 648266 648243 648244
648279
648296
648314
648285
648268
26.3 31.9 29.8 30.8 31.7 27.2 32.1 33.3 31.1 27.1
26.7
26.0
23.6
24.3
29.7
24.4 28.9 28.4 28.3 33.2 26.0 30.4 32.2 30.1 25.4
a
a
a
a
a
24.7 27.2 26.1 28.5 23.8 23.7 28.8 29.8 28.4 24.8
22.6
22.1
21.7
21.2
26.3
23.2 24.0 20.8 23.6 30.0
24.8 26.6 21.7 23.1 28.5
26.1 27.8 21.5 20.1 31.4
25.2 26.7 19.3 22.1 30.5
DuPont-6554
525
Company Sanitized. Doe not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Food Consuription
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 7
Day 15
Food Cons. g/anm/day
Day 21
Food Cons. g/anm/day
Day 28
Food Cons. g/anm/day
Day 35
Food Cons. g/anm/day
Day 42
Food Cons. g/anm/day
Day 49
Food Cons. g/anm/day
Day 56
Food Cons. g/anm/day
Day 63
Food Cons g/anm/day
Day 70
Male, IX - 300 mg/kg/day
648236 648217 648248 648218 648239 648293 648275 648308 648235 648289 648292 648272 648234 648240 648287 648277 648261 648306 648241 648284 648282 648231 648262 648230 648249
28.2 34.1 24.8 28.9 30.4 25.4 28.0 30.2 27.0 30.8 22.2 24.3 27.2 24.8 26.6 24.7 28.2 26.3 26.7 25.0 28.9 24.9 25.9 25.1 25.2
26.2 33.4 25.1 28.6 31.0 24.8 27.9 31.1 28.1 32.2 24.6 23.9 26.0 24.8 26.7 24.2 28.1 28.4 31.0 25.6 28.6 23.4 26.9 26.0 26.6
27.5 36.6 26.0 29.5 32.6 25.5 27.0 32.9 31.5 30.5 26.4 22.2 28.8 24.3 28.2 26.7 27.8 28.5 29.9 25.5 28.3 24.1 27.5 29.4 27.4
27.0 34.6 25.5 29.7 32.5 24.7 23.5 33.0 32.0 30.2 28.6 23.2 30.8 25.3 28.1 27.6 29.2 27.3 31.4 26.9 27.7 25.3 26.3 27.7 26.9
25.3 32.3 25.6 28.7 30.8 24.7 20.1 32.1 31.2 30.3 26.0 22.5 29.9 25.9 26.9 27.6 28.3 31.2 30.0 23.8 28.7 24.5 23.6 27.9 26.8
23.1 27.8 23.6 25.7 27.7 20.7 19.5 27.4 22.1 25.6 27.8 21.5 25.8 25.0 25.3 28.0 26.4 27.4 28.2 23.6 25.3 24.8 23.6 27.1 26.5
26.5 23.6 26.1 29.5 31.3 24.4 23.0 33.1 27.8 32.0 25.3 22.4 29.2 25.2 28.2 27.8 27.9 27.0 30.2 25.4 27.7 26.4 24.8 26.9 27.5
24.5 29.7 27.0 29.4 31.5 25.0 24.6 32.5 32.6 32.5 26.1 22.7 30.2 27.2 28.9 26.6 30.2 27.7 30.7 27.2 26.9 27.0 25.7 30.1 27.7
24.7 21.5 23.8 27.6 31.8 24.5 22.4 32.4 32.4 30.1 26.0 22.7 25.9 25.9 27.2 27.3 28.3 28.1 29.8 25.5 26.6
29.8 29.2 28.6
25.3 22.6 25.3 29.9 32.3 24.1 22.7 31.6 26.4 32.2 25.9 21.7 29.7 26.9 28.4 25.8 28.2 27.2 30.3 26.8 27.1
25.0 27.3 28.6
526
Company Sanitized- Does not contain TSCA CM
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Individual Food Consumption
Food Cons. g/anm/day
Day 77
Food Cons. g/anm/day
Day 84
Food Cons. g/anm/day
Day 91
Food Cons. g/anm/day
Day 98
Food Cons. g/anm/day
Day 105
Food Cons. g/anm/day
Day 113
Food Cons, g/anm/day
Day 119
Male, IX - 300 mg/kg/day
648236 648217 648248 648218 648239 648293 648275 648308 648235 648289
648292
648272
648234
648240
648287 648277 648261 648306 648241 648284 648282 648231 648262 648230 648249
25.2 32.3 25.9 28.8 32.0 24.9 22.9 33.8 28.0 32.3 28.7
22.9
30.4
27.1
29.0 28.3 29.4 25.5 31.5 26.3 28.2
25.6 26.1 26.8
26.6 33.9 26.6 29.4 33.4 24.1 23.9 31.7 29.1 29.4
a
a
a
a
a
27.5 27.1 28.6 30.3 24.9 26.0
24.4 26.2 28.0
26.3 33.9 26.9 30.1 23.4 35.6 23.1 30.9 28.3 27.5 24.8
21.7
24.4
23.1
26.6 25.8 26.4 26.3 29.9 26.3 25.9
22.0 24.6 29.8
27.8 18.3 27.9
25.8
29.2 27.3 27.0 29.5 33.2 27.5 27.4
23.7 27.6 29.4
28.9 21.5 27.3 25.8 30.9 30.0 30.8 30.1 33.1 29.1 27.8
24.6 31.8 28.9
27.4 24.1
31.3 26.4
32.5 30.8 29.9 31.8 31.4 29.0 28.1
25.4 31.7 28.3
26.5 24.0
31.4 26.2 30.2 30.5 31.2 30.3 31.5 28.9 27.1
25.2 28.5 28.3
)
DuPont-6554
527
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Food Consumption
Food Cons. g/anm/day
Day 7
Food Cons. g/anm/day
Day 15
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 21
Day 28
Food Cons. g /anm/day
Day 35
Food Cons. g/anm/day
Day 42
Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day
Day 49
Day 56
Day 63
Day 70
Female, II - 0 mg/kg/day
648421 648393 648436 648430 648351 648423 648353 648395 648372 648370 648356 648431 648422 648357 648405 648439 648389 648434 648425 648404 648394 648426 648346 648442 648427
21.3 19.0 21.0 18.8 18.9 20.1 18.7 18.5 18.9 17.3 18.6 18.8 18.3 18.5 17.2 22.5 18.0 19.2 25.2 19.3 19.2 25.1 20.4 24.7 22.8
24.4 19.1 22.3 20.4 19.3 22.2 19.5 19.1 21.0 18.2 18.1 16.6 18.6 19.8 18.2 22.7 18.3 20.0 25.1 22.4 20.3 23.2 21.1 27.3 23.9
24.5 21.7 23.2 19.0 20.3 20.9 21.0 18.6 23.7 17.9 18.6 18.3 19.2 19.8 18.6 25.2 18.5 22.9 23.9 22.4 20.7 25.1 20.2 26.8 26.0
26.5 21.0 20.3 21.2 18.7 20.8 21.5 19.8 24.3 19.6 19.1 18.2 19.0 20.3 18.4 25.8 18.9 24.6 26.2 22.1 21.3 29.6 22.9 28.9 23.9
25.9 18.2 19.1 18.3 20.4 22.1 20.8 17.5 23.6 19.7 18.3 17.8 20.0 21.0 18.8 22.3 20.5 24.4 25.4 19.8 21.2 27.6 21.4 26.6 21.4
21.8 17.9 19.9 17.1 18.5 18.8 17.1 17.1 19.8 18.3 19.2 19.2 19.4 19.3 19.2 22.6 13.2 22.3 23.8 19.5 20.0 25.8 21.6 25.2 21.9
26.7 18.7 22.0 20.7 21.9 22.8 20.8 19.3 25.8 20.8 18.8 19.7 20.4 22.7 19.2 23.5 19.0 22.1 23.8 18.1 20.7 25.9 21.1 24.2 20.9
25.6 19.7 22.9 20.6 21.3 21.3 21.9 19.2 24.2 17.7 19.4 19.4 19.4 19.8 18.3 24.5 18.6 22.8 25.3 19.0 19.5 27.6 22.4 26.5 21.3
25.1 19.6 20.6 21.8 20.8 22.5 18.9 17.7 21.3 17.2 21.1 17.3 16.1 20.2 17.3 22.2 18.2 20.3 23.6 16.5 19.8 24.7 20.4 23.8 21.0
27.6 18.2 20.9 18.9 20.0 22.1 19.8 19.2 26.4 18.1 18.2 19.8 17.6 19.5 17.9 23.8 18.5 24.0 24.3 18.9 20.9 24.8 20.6 23.3 23.7
528
Company Sanitized. Does not contain TSC CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Individual Food Consumption
Food Cons. g/anm/day
Day 77
Food Cons. g/anm/day
Day 84
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 91
Day 98
Day 105
Food Cons g/anm/day
Day 113
Female, II - 0 mg/kg/day
648421 648393 648436 648430 648351 648423 648353 648395 648372 648370
648356
648431
648422
648357
648405 648439 648389 648434 648425 648404 648394 648426 648346 648442 648427
26.8 20.5 20.4 19.0 18.6 21.4 22.0 18.0 25.4 18.0
17.9
18.5
18.5
19.3
18.7 21.6 18.9 24.0 22.5 16.6 21.5 22.1 19.6 24.7 22.9
25.9 21.2 23.7 20.9 22.4 20.7 19.2 17.9 25.2 18.6
a
a
a
a
a
23.0 17.9 21.1 24.3 15.0 20.2 20.1 21.3 25.2 30.4
23.4 18.1 18.4 19.1 18.3 20.0 20.7 16.4 27.0 16.9
19.4
16.3
16.3
18.7
18.5 22.3 17.8 19.6 22.6 14.5 19.4 18.3 18.9 21.3 19.5
19.9
17.4
18.1
17.3
14.0 23.8 17.4 20.8 25.9 18.2 19.6 24.3 20.4 24.3 22.5
18.4
17.0
19.0
17.2
14.8 23.9 18.3 24.4 24.4 16.8 20.9 27.3 20.1 25.8 21.9
19.2
19.0
20.2
17.2
16.2 24.8 20.0 24.9 20.2 20.0 19.8 21.6 23.3 26.9 21.5
Food Cons, g/anm/day
Day 119
17.4 19.5 19.7 17.5 16.5 21.7 19.8 23.7 26.9 17.9 20.3 24.7 22.3 21.2 18.9
DuPont-6554
529
Company Sanitized. Does not contain TSC CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Food Consumption
Food Cons. Food Cons.
g/anm/day g/anm/day
uay /
Day 15
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 21
Day 28
Day 35
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 42
Day 49
Day 56
Food Cons. g/anm/day
Day 63
Food Cons g/anm/day
Day 70
Female, IV - 60 mg/kg/day Isopropanol
648396 648409 648410 648369 648397 648364 648408 648402 648424 648390
20.8 21.0 19.8 21.2 20.1 21.4 19.6 19.3 18.5 20.0
21.1 21.3 22.1 20.9 20.9 20.7 19.7 20.0 17.7 21.7
22.7 22.4 22.1 23.4 22.3 21.5 20.1 19.3 20.2 21.9
22.3 21.5 21.9 19.2 20.9 21.5 21.0 20.6 20.4 20.9
20.4 21.7 21.2 19.8 20.4 20.8 19.7 22.0 20.6 21.4
20.7 19.2 18.9 16.4 20.5 19.5 19.1 19.2 19.4 19.3
22.2 20.0 21.5 19.2 22.8 21.8 21.1 23.1 21.5 21.5
21.7 20.9 21.5 19.8 22.0 21.2 21.3 23.7 21.0 20.3
21.2 19.6 14.6 18.3 19.3 20.7 19.4 23.0 22.2 19.5
21.5 20.2 19.9 20.1 23.2 21.8 21.9 21.9 23.7 19.7
530
Company Sanitized, oes not contain TSC& reu
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________
Individual Food Consumption
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 77
Day 84
Day 91
Day 98
Day 105
Day 113
Day 119
Female, IV - 60 mg/kg/day Isopropanol
648396 648409 648410 648369 648397 648364 648408 648402 648424 648390
20.6 19.5 21.0 18.4 20.7 23.5 22.0 21.1 23.4 19.2
22.5 17.0 20.9 24.2 22.1 21.7 19.9 21.7 22.2 18.5
22.3 18.8 21.2 18.5 19.6 20.7 18.9 20.7 21.3 19.2
DuPont-6554
531
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Food Consumption
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 7
Day 15
Day 21
Day 28
Day 35
Food Cons g/anm/day
Day 42
Female, VI - 10 mg/kg/day
648433 648406 648441 648414 648366 648382 648345 648374 648403 648429 648384 648352 648365 648413 648385
19.6 22.6 19.1 18.9 21.4 18.7 17.3 19.7 21.1 22.0 18.0 16.8 19.3 21.0 18.5
19.6 21.1 20.4 18.9 24.9 19.6 16.8 20.0 18.6 22.6 17.7 18.0 19.7 21.6 18.5
21.4 21.5 22.6 20.4 24.6 17.3 17.6 22.5 19.6 24.4 19.3 19.3 19.8 23.6 20.7
19.3 22.2 22.0 20.9 22.8 20.5 18.9 21.1 19.0 24.8 19.9 20.0 20.7 21.2 20.2
19.8 21.4 19.1 20.9 22.7 20.9 18.2 22.1 20.3 23.8 20.1 19.9 20.4 23.0 19.9
18.8 18.3 18.3 18.7 21.5 18.7 15.9 20.5 16.9 21.3 18.6 16.8 17.8 22.5 19.1
532
)
DuPont-6554
Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day
Day 49
Day 56
Day 63
Day 70
21.8 22.3 20.7 19.5 25.6 21.0 17.9 21.6 17.8 21.2 18.7 19.2 20.5 24.2 19.9
21.9 23.5 23.4 20.7 23.6 20.1 16.9 21.3 19.7 22.6 19.4 20.3 20.5 23.9 19.0
19.5 20.4 18.9 20.6 20.0 20.2 17.6 19.3 17.3 21.7 17.2 20.7 19.0 23.0 18.2
18.4 21.8 20.0 18.1 23.3 19.6 17.4 21.5 18.8 22.9 19.4 21.5 19.9 24.0 18.6
Con*mf S3"f e <- D o c not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Individual Food Consumption
Food Cons. g/anm/day
Day 77
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 84
Day 91
Food Cons. g/anm/day
Day 98
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 105
Day 113
Food Cons g/anm/day
Day 119
Female, VI - 10 mg/kg/day
648433 648406 648441 648414 648366 648382 648345 648374 648403 648429
648384
648352
648365
648413
648385
21.3 22.4 19.3 18.3 21.6 19.8 17.3 22.5 17.5 22.8
22.2
21.0
19.0
24.2
20.2
19.3 21.6 21.3 19.5 23.1 19.9 18.6 22.8 18.8 24.7
a
a
a
a
a
19.2 20.6 19.3 21.7 24.4 19.9 17.0 19.7 17.0 22.1
17.8
18.3
22.5
21.8
18.8
13.5 19.8 20.3 25.7 22.3
21.6 21.2 18.9 25.3 21.7
20.0 23.3 22.8 26.0 24.1
19.8 21.9 21.8 23.8 19.6
)
DuPont-6554
533
Company Sanitized. Does not contain TSCA C
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Food Consumption
Food Cons. g/anm/day
Day 7
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 15
Day 21
Food Cons g/anm/day
Day 28
Female, VIII - 60 mg/kg/day
Food Cons. g/anm/day
Day 35
Food Cons. g/anm/day
Day 42
Food Cons. g/anm/day
Day 49
Food Cons. Food Cons
g/anm/day g/anm/day
Day 56
Day 63
648380 648381 648432 648440 648348 648417 648368 648401 648362 648354 648349 648415 648379 648386 648360
21.5 19.1 21.6 21.7 20.2 19.1 20.3 19.3 18.7 18.7 18.8 20.0 18.7 15.9 18.0
22.4 18.7 22.7 22.9 21.8 22.1 23.6 20.4 19.9 18.5 18.4 20.3 20.0 18.9 19.1
24.2 20.1 23.7 22.7 22.6 22.3 20.2 21.7 19.2 18.9 19.1 21.3 20.1 15.2 20.0
22.4 18.4 24.6 25.9 22.2 21.5 21.6 20.9 19.0 17.6 20.9 21.0 19.0 21.6 20.4
21.9 18.6 24.9 24.4 21.8 21.1 20.0 19.4 17.3 17.8 20.5 20.2 21.6 20.6 20.6
20.1 16.3 21.8 25.3 21.0 19.8 19.7 17.8 17.0 17.4 19.4 22.4 22.0 22.6 19.8
23.0 20.3 25.6 25.6 24.1 21.1 19.6 22.5 20.4 18.9 21.1 22.3 21.6 21.6 20.6
24.5 18.0 25.3 26.5 21.9 22.0 23.0 20.6 19.8 19.0 23.5 21.4 21.8 22.8 20.2
23.3 18.2 24.6 22.4 22.9 21.3 23.2 18.6 19.4 16.8 21.1 21.2 21.2 20.3 18.9
Food Cons, g/anm/day
Day 70
23.5 20.3 25.9
2242.. 62
21.9 17.6 21.2 18.5 18.4 19.9 20.2 20.3 21.0 20.0
534
Company Sanitized. Does not contain TSCA CB!
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Individual Food Consumption
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 77
Day 84
Food Cons. g/anm/day
Day 91
Food Cons. g/anm/day
Day 98
Food Cons. g/anm/day
Day 105
Food Cons. g/anm/day
Day 113
Food Cons g/anm/day
Day 119
Female, VIII - 60 mg/kg/day
648380 648381 648432 648440 648348 648417 648368 648401 648362 648354
648349
648415
648379
648386
648360
23.2 19.4 25.0 25.4 21.9 22.7 17.1 20.7 17.6 17.8 22.1
20.4
20.9
20.9
19.3
23.3 20.5 28.1 25.6 22.1 22.3 18.7 21.1 19.1 18.2
a
a
a
a
a
22.1 19.8 26.6 26.1 22.0 19.6 17.8 19.4 17.8 17.0
21.4
19.5
20.5
20.1
18.2
21.3 20.6 21.5 15.1 20.9
21.1 20.4 25.8 17.3 21.5
21.1 22.7 28.0 18.3 23.9
18.5 21.9 23.8 21.7 19.9
)
DuPont-6554
535
Company Sanitized. Does not contain TSCA CBl
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
)
DuPont-6554
Individual Food Consumption
Food Cons. g/anm/day
Day 7
Food Cons. g/anm/day
Day 15
Food Cons. g/anm/day
Day 21
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 28
Day 35
* Day 42
Day 49
Day 56
Day 63
Food Cons g/anm/day
Day 70
Female, X - 300 mg/kg/day
648407 648392 648435 648376 648347 648412 648438 648400 648388 648373 648358 648367 648391 648411 648355 648387 648419 648378 648398 648350 648383 648359 648399 648363
20.4 19.6 19.5 21.0 20.6 15.9 18.5 21.0 20.6 21.4 16.4 19.8 19.2 19.7 19.7 16.8 19.1 18.7 19.6 22.6 17.3 18.4 20.8 20.2
20.6 18.5 20.6 22.7 20.5 17.5 19.1 21.7 21.1 20.3 16.3 19.9 18.6 20.9 18.8 18.5 26.4 18.7 19.7 22.0 17.3 18.7 21.3 23.5
21.6 20.6 21.9 22.1 21.7 18.3 20.9 22.3 22.5 21.2 18.0 22.0 18.8 21.9 18.3 19.4 14.6 20.9 19.6 22.2 17.7 19.5 22.1 25.6
22.6 20.5 20.5 21.5 21.6 18.1 22.6 23.7 21.7 23.2 17.7 20.2 19.9 21.7 19.6 19.9 20.6 21.9 19.0 23.4 18.8 23.3 22.8 23.3
21.5 18.8 23.7 25.5 21.3 19.6 20.9 21.5 22.2 21.0 17.3 19.6 22.3 21.6 18.7 21.4 20.8 20.9 20.3 25.5 19.2 22.5 21.2 22.6
17.7 19.2 19.0 18.7 17.7 16.6 18.6 19.2 16.9 21.3 16.3 19.1 18.4 21.6 19.1 19.8 19.7 20.4 20.7 25.0 18.3 21.4 22.7 21.4
22.6 21.3 22.6 21.3 22.1 18.8 23.2 23.1 22.0 23.7 18.3 22.2 20.5 22.7 19.7 21.4 19.9 22.3 21.1 25.5 19.2 21.2 21.5 23.4
21.9 20.5 22.8 21.6 22.1 18.4 24.1 23.6 22.1 24.9 18.9 22.3 18.8 20.4 19.4 21.2 20.2 21.5 21.7 24.7 17.9 22.2 21.6 23.0
20.6 17.1 23.4 22.5 21.2 19.9 21.6 21.0 20.8 22.6 17.3 20.4 17.2 20.0 19.5 18.1 19.5 21.1 20.3 23.3 17.1 22.9 20.9 21.6
21.6 19.6 23.8 21.3 21.0 19.0 22.2 23.3 21.1 22.7 16.9 20.5 21.1 21.1 19.8 19.1 20.0 20.2 22.1 25.2 19.3 23.1 21.3 23.7
536
Company Sanitized. Does not contain TSCA CB!
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______________________________
_____________________________________________
Individual Food Consumption
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 77
Day 84
Day 91
Day 98
Day 105
Day 113
Day 119
Female, X - 300 mg/kg/day
648407 648392 648435 648376 648347 648412 648438 648400 648388
648373
648358
648367
648391
648411 648355 648387 648419 648378 648398 648350 648383 648359 648399 648363
21.8 19.4 23.9 20.9 21.5 18.5 22.0 22.9 20.2
21.0
15.8
21.8
19.8
20.0 19.8 18.0 18.6 20.6 20.2 23.7 18.2 21.7 22.0 22.7
21.9 18.6 24.7 21.6 20.2 18.9 21.3 20.4 19.9
a
a
a
a
a
18.1 19.5 19.3 19.3 20.6 23.1 17.8 23.1 20.5 19.9
20.2 20.6 24.8 20.4 21.2 20.4 22.2 21.4 20.3
19.5
14.8
19.1
19.4
19.0 18.8 15.9 18.7 17.6 20.7 22.9 17.5 19.3 17.9 23.0
19.9
14.1
21.1
19.9
20.9 19.3 17.5 19.3 20.9 23.2 20.6 18.4 21.9 21.5
22.0
16.6
22.3
20.8
19.6 19.2 19.9 20.0 23.3 21.2 24.0 19.3 23.8 21.6
22.0
17.5
24.6
21.0
21.5 20.9 21.9 20.3 21.5 20.8 22.9 18.8 25.5 22.1
20.8
17.8
22.7
17.5
21.3 19.6 21.7 20.6 20.3 22.6 24.6 20.7 26.1 20.5
DuPont-6554
537
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIXE
INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY RECORDS
538
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY RECORDS
Study Design
EXPLANATORY NOTES
Group
Male Female Dosage
I n 0 mg/kg/day in IV 60 mg/kg/day
V VI 10 mg/kg/day
v n vm 60 mg/kg/day
IX X 300 mg/kg/day
Test Substance Vehicle control Isopropanol control H-24678 H-24678 H-24678
Critical Dates
Day 90 > Last day of test substance administration for male and female rats designated for the one-month and 3-month recovery periods.
Day 91 > Last day of test substance administration for male rats designated for the 90-day exposure period.
> Recovery period begins for rats designated for the one-month and 3-month recovery periods.
Day 92 > Last day of test substance administration for female rats designated for the 90-day exposure period.
> Male rats designated for the 90-day exposure period were sacrificed.
> Male rats dosed with isopropanol (Group III) were sacrificed.
Day 93 > Female rats designated for the 90-day exposure period were sacrificed. > Female rats dosed with isopropanol (Group IV) were sacrificed.
Day 122 > Male and female rats designated for the one-month recovery period were sacrificed.
Day 183 > Male and female rats designated for the 3-month recovery period were sacrificed.
539
.parqf Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
MI
648225 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
MI
648247 General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Bilateral
38
Eye Observations, Bled via Orbital for Clin Path, Right
92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
MI
648307 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
MI
648294
Sacrificed by design General observation. No Abnormality Detected
92 0-35
Eye Observations, Bled via Orbital for Clin Path, Right
38
Accidentally killed
38
MI
648315 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
MI
648256 General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
)
DuPont-6554
540
Company Sanitized. Does not contain TSCA CB1
>
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
>
DuPont-6554
Sex Group Animal
MI
648256
MI
648255
MI
648246
MI
648238
MI
648220
MI
648298
individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Sacrificed by design
92
General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-7,28-35,42-63,84
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
Hyperreactive
15-21,70-77,91-92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Bilateral
38
Eye Observations, Bled via Orbital for Clin Path, Right
92
Retina, Retinal Degeneration Focal, Left
81
Sacrificed by design.
92
General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0,7,15-84,91,98,105, 133-140,147-161,168-183
Eye Observations, Bledvia Orbital for Clin Path, Bilateral
183
Eye Observations, Bledvia Orbital for Clin Path, Left
0,77,88,116
Eye Observations, Bledvia Orbital for Clin Path, Right
3,9,21,35,56,93,97,102,109,127,141,162
541
Company Sanitized. Does not contain TSCA CBI
)))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
MI
648298 Sacrificed by design
183
MI
648228 General observation, No Abnormality Detected
0,7,15-42,56-84,91,105,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Bilateral
3,9,109
Eye Observations, Bled via Orbital for Clin Path, Left
0,21,35,56,77,183
Eye Observations, Bled via Orbital for Clin Path, Right
88,93,97,102,116,127,141,162
Discharge, Penis, Red
98
Discharge, Nose, Black
49,113
MI
648297
Sacrificed by design General observation, No Abnormality Detected
183
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,183
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162
MI
648219
Sacrificed by design General observation, No Abnormality Detected
183 0,7,15-42
Eye Observations, Bled via Orbital for Clin Path, Bilateral
56
Eye Observations, Bled via Orbital for Clin Path, Left
0,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162 183
Protrusion, Umbilical Hernia
49-84,91,98,105,113,119-126,133-140, 147-161,168-183
MI
648226
Sacrificed by design General observation, No Abnormality Detected
183
0,7,15-21,84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Bilateral
0
Eye Observations, Bled via Orbital for Clin Path, Left
56,77
542
Company Sanitized. Bees not contain TSCA CBI
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________________________ __________________
.
)
DuPont-6554
Sex Group Animal
MI
648226
MI
648222
MI
648250
MI
648271
MI
648260
MI
648264
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162, 183
Hyperreactive
28-77
Sacrificed by design
183
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation. No Abnormality Detected
0-49,84-105,119-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
Aggressive Behavior
56-77
Hyperreact ive
70-77,113
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
543
Company Sanitized. Doss not confaiTM
_
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Sex Group Animal
MI
648264
MI
648233
MI
648311
MI
648257
MI
648278
MI
648216
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation. No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation. No Abnormality Detected
0-49,63-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Urine, Present, Clear
56
Sacrificed by design
122
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Left
0
)
DuPont-6554
544
Company g;
s nof
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
MI
648216
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
DuPont-6554
545
Company Sanitized, Dies not contain TSCA w a
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal M III 648302
M III 648274
M III 648227 M III 648299
M III
648303
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation. No Abnormality Detected
0-21
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
Hyperreact ive
28-35,42-77
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forepaw, Bilateral
63-77,84-92
Hair Loss, Forepaw, Right
56
Sacrificed by design
92
General observation, No Abnormality Detected
0-35,42-77
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
Hyperreactive
84-92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-21
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Bilateral
84-92
Hair Loss, Forepaw, Bilateral
28-35,42-77
Sacrificed by design
92
General observation. No Abnormality Detected
0-35,42-77,84-92
DuPont-6554
546
Company Sanitized, Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal M III 648303
Observation Eye Observations, Bled via Orbital for Clin Path, Right
Days 38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M III 648269 General observation, No Abnormality Detected
0-35,42-77
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Stain Fur/Skin, Forelimb, Bilateral, Brown
84-92
Sacrificed by design
92
M III 648252 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M III 648290 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M III 648258 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M III
648232 General observation, No Abnormality Detected
0-35,42-77,84
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
DuPont-6554
547
Company Sanitized. Does not contain TSCA CBJ
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Sex Group Animal M III 648232
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Mass Inguen, Left, Mass #1, Not Ulcerated, 4.0 cm
91-92
Mass Inguen, Left, Mass #1, Not Ulcerated, 3.5 cm
88
Sacrificed by design
92
DuPont-6554
548
Company Sanitized. Does not contain TSC CB8
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
MV
648288 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
MV
648286 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
MV
648309 General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
MV
648312 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
MV
648221 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Bilateral
38
Eye Observations, Bled via Orbital for Clin Path, Right
92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
DuPont-6554
549
Company Sanitized. Does not contain TSCA CB1
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________
Sex Group Animal
MV
648273
MV
648245
MV
648301
MV
648224
MV
648283
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation. No Abnormality Detected
0-7,28-35,42,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
Hyperreactive
15-21,49-77
Feces, Present, Brown
63
Feces, Present
49
Retina, Retinal Degeneration Focal, Left
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-35,42-77,84
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
Hyperreactive
91-92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-35,42-49,77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forepaw, Right
56-70
Sacrificed by design
92
General observation. No Abnormality Detected
0,7,15-84,91,98,105, 133-140,147-161,168-:
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,183
)
DuPont-6554
550
Company Sanitized. Does not contain TSCA CIS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
MV
648283 Eye Observations, Bled via Orbital for Clin Patfi, Right
3,9,21,35,88,93,97,102,109,116,127,141,162
Eye Observations, miss dosed did not bleed
35
Sacrificed by design
183
MV
648254 General observation, No Abnormality Detected
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via OrbitalforClinPath, Bilateral
0,9,56,77
Eye Observations, Bled via OrbitalforClinPath, Left
183
Eye Observations, Bled via OrbitalforClinPath, Right
3.21.35.88.93.97.102.109.116.127.141.162
Eye Observations, miss dosed, did not bleed
35
Mv
648310
Sacrificed by design General observation, No Abnormality Detected
183
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,183
Eye Observations, Bled via Orbital for Clin Path, Right
3.9.21.35.88.93.97.102.109.116.127.141.162
Sacrificed by design
183
MV
648265 General observation, No Abnormality Detected
0,7,15-21,35-42,113,119-126, 133-140,168-183
Eye Observations, Bledvia Orbital for Clin Path, Bilateral
0
Eye Observations, Bledvia Orbital for Clin Path, Left
3,9,21,35,56,77
Eye Observations, Bledvia Orbital for Clin Path, Right
88,93,97,102,109,116,127,141,162,183
Discharge, Eye right, Black
147
Hair Loss, Face, Right
147-161
Hair Loss, Head, Dorsal
77-84,91,98,105
Scab, Head
84,91
Wound, Superficial, Shoulder, Left
28
551
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
>
DuPont-6554
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
MV
648265 Wound, Superficial, Shoulder, Right
49-77
Wound, Superficial, Head
70-77
Sacrificed by design
183
MV
648253 General observation, No Abnormality Detected
0,7,15-84,91,98,105,113,119-126,133, 168
Eye Observations, Bled via Orbital for Clin Path, Bilateral
109
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,116,127,141,162,183
Wound, Superficial, Head
140,147-161
Stain Fur/Skin, Shoulder, Bilateral, Brown
175-183
Sacrificed by design
183
MV
648313 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Left
0
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
552 *
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
M VII
648300
M VII 648305
M VII 648280
M VII
648259
M VII 648223
M VII
648270
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Hair Loss, Foreliirib, Right
49-77
Hair Loss, Forepaw, Bilateral
7-35,42-77,84-92
Sacrificed by design
92
General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0
DuPont-6554
553
Company Sanitized. Does not contain TSC CBi
)} ) .
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______________________________________________________________ __________________________ DuPont-6554
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal
M VII
648270
Observation Eye Observations, Bled via Orbital for Clin Path, Right
Days 38,92
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Bilateral
35,42-77
Hair Loss, Forelimb, Left
28
Hair Loss, Forepaw, Bilateral
35,42-77
Hair Loss, Forepaw, Left
7-28,84-92
Sacrificed by design
92
M VII
648237 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M VII 648266 General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M VII 648243 General observation, No Abnormality Detected
0-28,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Bilateral
38
Eye Observations, Bled via Orbital for Clin Path, Right
92
No Ophthalmological Abnormalities Detected
81
Stain Fur/Skin, Face, Red
35
Sacrificed by design
92
M VII
648244 General observation, No Abnormality Detected
0-35,42-49
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
554
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
))
__________________________ DuPont-6554
Sex Group Animal
M VII
648244
M VII
648279
M VII
648296
M VII 648314
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
No Ophthalmological Abnormalities Detected
81
Misshapen Observations, Ear, Left
56-77,84-92
Sacrificed by design
92
General observation, No Abnormality Detected
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Bilateral
0,77,88
Eye Observations, Bled via Orbital for Clin Path, Left
56,183
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,93,97,102,109,116,127,141,162
Sacrificed by design
183
General observation, No Abnormality Detected
0
Eye Observations, Bled via Orbital for Clin Path, Bilateral
77
Eye Observations, Bled via Orbital for Clin Path, Left
0,9,56,183
Eye Observations, Bled via Orbital for Clin Path, Right
3,21,35,88,93,97,102,109,116,127,141,162
Discharge, Eye left, Black
49-63
Discharge, Eye right. Black
28-42,119-126
Hair Loss, Base of tail
105,113,119-126,133-140,147-161, 168-183
Hair Loss, Forelimb, Bilateral
7,15-77,105,113,119-126,133-140, 147-161,168-183
Hair Loss, Forepaw, Bilateral
84,91,98,105,113,119-126,133-140, 147-161,168-183
Hair Loss, Forepaw, Right
7,15-77
Sacrificed by design
183
General observation, No Abnormality Detected
0,7,15-63,77-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Bilateral
3,9
555
Company Sanitized. Does not contain TSCA GBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
M VII
648314
Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right
0,56,77,183 21,35,88,93,97,102,109,116,127,141,162
Wound, Superficial, Nose
70
Swollen Observations, Nose
66
Sacrificed by design
183
M VII
648285
General observation. No Abnormality Detected Eye Observations, Partially closed, Left
0,7,15-56
77-84,91,98,105,113,119-126,133-140, 147-161,168-183
Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left
70-77 63
Eye Observations, Exophthalmus, Right
98
Eye Observations, Bled via Orbital for Clin Path, Bilateral
56
Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right
0,9
3,21,35,77,88,93,97,102,109,116,127,141 162,183
Eye Observations, Corneal Opacity, Bilateral
105,113,119-126,133-140,147-161, 168-183
Eye Observations,. Corneal Opacity, Left
63-84,91,98
Hair Loss, Face, Left
70
Wound, Superficial, Eyelid, Left
63
Sacrificed by design
183
M VII 648268 General observation. No Abnormality Detected
0,7,15-21
Eye Observations, Bled via Orbital for Clin Path, Left
0,9,56,77,141,162
Eye Observations, Bled via Orbital for Clin Path, Right
3,21,35,88,93,97,102,109,116,127,183
Eye Observations, Corneal Opacity, Right
147-161,168-183
556
Company Sanitized. Does not contain TSCA CBt
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________
Sex Group Animal M VII 648268
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Discharge, Nose, Black
98
Discharge, Eye right, Black
98,105,133-140,147,161,168
Hair Loss, Forelirrib, Bilateral
28-84,91,98,105,113,119-126,133 147-161,168-183
Hair Loss, Forepaw, Bilateral
70-77
Sacrificed by design
183
)
DuPont-6554
557
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
M IX
648236 General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38.92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M IX
648217 General observation, No Abnormality Detected
0-35,84-92
Eye Observations, Bled via Orbital for Clin Path, Bilateral
38
Eye Observations, Bled via Orbital for Clin Path, Right
92
General Teeth Observations, Broken
63-77
Hyperreactive
42-77
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M IX
648248 General observation, No Abnormality Detected
0-15,28-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38.92
Hyperreactive
21
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M IX
648218 General observation, No Abnormality Detected
0-7,84-92
Eye Observations, Bled via Orbital for Clin Path, Bilateral
38
Eye Observations, Bled via Orbital for Clin Path, Right
92
Hyperreactive
15-35,42-77
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
M IX
648239 General observation, No Abnormality Detected
0-35,42-77,84
DuPont-6554
558
Company Sanitized. Does not contain TSCA CB1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
M IX
648239
M IX
648293
M IX
648275
M IX
648308
M IX
648235
M IX
648289
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
Hyperreactive
91-92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation. No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Bilateral
38
Eye Observations, Bled via Orbital for Clin Path, Right
92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38, 92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-35,42-77,84-92
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
92
General observation, No Abnormality Detected
0-28
Eye Observations, Bled via Orbital for Clin Path, Right
38,92
DuPont-6554
559
Company Sanitized. Does not contain TSCA CBI
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________
)
DuPont-6554
Sex Group Animal
M IX
648289
M IX
648292
M IX
648272
M IX
648234
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Right Hair Loss, Forepaw, Right
35,42-77 49-77,84-92
Sacrificed by design
92
General observation, No Abnormality Detected
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,97,102,183
Eye Observations, Bled via Orbital for Clin Path, Right
3.9.21.35.88.93.109.116.127.141.162
Sacrificed by design
183
General observation. No Abnormality Detected
0,7,15-84,91
Eye Observations, Partially Closed, Right
98
Eye Observations, Exophthalmus, Right
98
Eye Observations, Bled via Orbital for Clin Path, Bilateral
0,21,35
Eye Observations, Bled via Orbital for Clin Path, Left
56.77.97.102.183
Eye Observations, Bled via Orbital for Clin Path, Right
3.9.88.93.109.116.127.141.162
Eye Observations, Corneal Opacity, Right
105,113,119-126,133-140,147-161, 168-183
Discharge, Eye right, Black
98
Wound, Superficial, Head
105
Sacrificed by design
183
General observation, No Abnormality Detected
0,84,91,98
Eye Observations, Bled via Orbital for Clin Path, Bilateral
21.35.102.183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,97
Eye Observations, Bled via Orbital for Clin Path, Right
3.9.88.93.109.116.127.141.162
560
Company Sanitized. Does not contain TSCA CBS
)))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats________________
DuPont-6554
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
M IX
648234 Hair Loss, Abdomen, Right
161,168-183
Hair Loss, Forelimb, Right
105,113,119-126,133-140,147-161, 168-183
Hair Loss, Forepaw, Right
7,15-77
Hair Loss, Inguen, Right
154-161,168-183
Sacrificed by design
183
M IX
648240 General observation, No Abnormality Detected
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Bilateral
3,9,141
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
21,35,88,93,97,102,109,116,127,162,183
M IX
648287
Sacrificed by design General observation, No Abnormality Detected
183
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Bilateral
21,35,116
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,109
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,88,93,97,102,127,141,162,183
M IX
648277
Sacrificed by design General observation, No Abnormality Detected
183 0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
M IX
648261
Sacrificed by design General observation, No Abnormality Detected
122 0-28,84-122
561
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
M IX
648261 Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forepaw, Bilateral
35-77
Sacrificed by design
122
M IX
648306
General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral
0-77,91-105 122
Hyperreactive
84,113-122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
M IX
648241 General observation. No Abnormality Detected
0-21,35,49-77,119-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
Hyperreactive
42,84-113
No Ophthalmological Abnormalities Detected
81
Feces, Present
28
Sacrificed by design
122
M IX
648284 General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
M IX
648282
Sacrificed by design General observation, No Abnormality Detected
122 0
Eye Observations, Bled via Orbital for Clin Path, Right
122
DuPont-6554
562
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
M IX
648282
M IX
648231
M IX
648262
M IX
648230
M IX
648249
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Bilateral
35-77,105-122
Hair Loss, Forepaw, Bilateral
7-77,84-122
Sacrificed by design
122
General observation. No Abnormality Detected
0-57
Found dead in cage.
57
General observation, No Abnormality Detected
0-77,91-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
Hyperreac tive
84
Discharge, Mouth, Red
84
No Ophthalmological Abnormalities Detected
81
Comments, rat fell from cage, hit mouth
84
Sacrificed by design
122
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Left
0
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation, No Abnormality Detected
0-56
Eye Observations, Bled via Orbital for Clin Path, Left
0
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Hair Loss, Shoulder, Bilateral
84-98
DuPont-6554
563
Company Sanitized. Does not contain TSCA CM
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
M IX
648249
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Hair Loss, Shoulder, Left
70-77
Hair Loss, Shoulder, Right
105-122
Wound, Superficial, Shoulder, Left
63
Wound, Superficial, Shoulder, Right
84
Sacrificed by design
122
DuPont-6554
564
Company Sanitized. Does not contain TSCA CBI
))
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______________________________________________________________________ ______________ _______ DuPont-6554
Sex Group Animal
F II
648421
F II
648393
F II
648436
F II
648430
F II
648351
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
93
Eye Observations, Bled via Orbital for Clin Path, Right
39
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
565
,tcontain TSCACB1
Sanitized-Doesn0<
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
sex Group Animal Observation
Days
F II
648351 Sacrificed by design
93
F II
648423 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F II
648353 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F II
648395 General observation. No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F II
648372 General observation, No Abnormality Detected
0-35,42-56,63,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Right
70-77
Comments, compound evident on mouth
61
Sacrificed by design
93
F II
648370 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
DuPont-6554
566
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
DuPont-6554
Sex Group Animal
F II
648370
F II
648356
F II
648431
F II
648422
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Sacrificed by design
93
General observation, No Abnormality Detected
0,7,15-77
Eye Observations, Exophthalmus, Left
84
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3.9.21.35.88.93.97.102.109.116.127.141.162, 183
Eye Observations, Corneal Opacity, Left
91.98.105.113.119- 126,133-140, 147-161,168-183
Eye Observations, Dark, Right
98,105
Sacrificed by design
183
General observation, No Abnormality Detected
0,84
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3.9.21.35.88.93.97.102.109.116.127.141.162, 183
Hair Loss, Forelimb, Bilateral
105.113.119168-183
126,133-140,147-161,
Hair Loss, Forepaw, Bilateral
7,15-77,91,98,105,113,119-126,133-140, 147-161,168-183
Sacrificed by design
183
General observation, No Abnormality Detected
0,7,15-56
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,93,97,102,109,116,127,141,162,183
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88
Eye Observations, Corneal Opacity, Right
77-84,91,98,105,113,119-126,133-140, 147-161,168-183
Eye Observations, Pale, Right
63-70
Stain Fur/Skin, Head, Brown
182-183
567
rtoa* contain TSCA CB!
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
F II
648422 Sacrificed by design
183
F II
648357 General observation. No Abnormality Detected
0,7,15-63,84,91
Eye Observations, Partially Closed, Bilateral
119-126,133-183
Eye Observations, Exophthalmus, Right
98.105.113
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,97,102,109,116,127
Eye Observations, Bled via Orbital for Clin Path, Right
3.9.21.35.88.93
Eye Observations, Corneal Opacity, Bilateral
119-126,133-183
Eye Observations, Dark, Right
98,105
Discharge, Eye left. Black
105
Hair Loss, Face, Right
105,113,119-126,133
Wound, Superficial, Face
70-77
Comments, tail vein bled on 10/23/01
162
Comments, tail vein bled 10/2/01
141
Swollen Observations, Face
98,105,113,119
Sacrificed by design II 648405 General observation. No Abnormality Detected
183 0,7,15-42
Eye Observations, Partially Closed, Right
182-183
Eye Observations, Enophthalmus, Right
119-126,133-140,147-161,168-183
Eye Observations, Exophthalmus, Right
98.105.113
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,97,102,109,116,127,141,162,183
Eye Observations, Bled via Orbital for Clin Path, Right
3.9.21.35.88.93
Eye Observations, Corneal Opacity, Right
119-126,133-140,147-161,168-183
Eye Observations, Dark, Right
98.105.113
568
Company Sanitized. Do< oteontain TSCA CBl
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
) DuPont-6554
Sex Group Animal II 648405
II 648439 II 648389
II 648434 II 648425
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Discharge, Eye bilateral, Black
147
Discharge, Eye right. Black
105,113
Hair Loss, Forelimb, Bilateral
147-161,168-183
Hair Loss, Forepaw, Bilateral
49-84,91,98,105,113,119-126,133-140, 147-161,168-183
Swollen observations. Face
113,119-126,133-140,147-161,168-182
Sacrificed by design
183
General observation, No Abnormality Detected
0-77,84-119
No Ophthalmological Abnormalities Detected
81
Accidentally killed, animal died acc before blood was taken
122
General observation, No Abnormality Detected
0-49,84-122
Eye Observations, Bled via Orbital for Clin Path, Right, .
122
Hyperactive
56-77
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122 I
General observation, No Abnormality Detected
0-77,122
Eye Observations, Bled via Orbital for Clin Path, Right
122
General Teeth Observations, Clipped
84-119
569
net contain TSCACBI Company Sanitized. Does
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
F II
648425
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
No Ophthalmological Abnormalities Detected
#
81
F II
648404
Sacrificed by design General observation, No Abnormality Detected
122 0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
F II
648394
Sacrificed by design General observation, No Abnormality Detected
122 0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
F II
648426
Sacrificed by design General observation, No Abnormality Detected
122 0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
F II
648346
Sacrificed by design General observation, No Abnormality Detected
122 0-42,84
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Bilateral
49-77,119-122
Hair Loss, Forepaw, Bilateral
49-77,91-122
F II
648442
Sacrificed by design General observation, No Abnormality Detected
122 0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
DuPont-6554
570
Company Sanitized. Does not contain TSGA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
F II
648442
F II
648427
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Sacrificed by design
122
General observation, No Abnormality Detected
42-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Left
0
Eye Observations, Bled via Orbital for Clin Path, Right
122
Eye Observations, Corneal Opacity, Right
0-35
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
DuPont-6554
571
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
F IV
648396 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F IV
648409 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F IV
648410 General observation, No Abnormality Detected
0-35,63,84
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
Hyperactive
42-56,70-77,91-93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F IV
648369 General observation, No Abnormality Detected
0-35,42,56-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
Discharge, Eye right, Black
49
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F IV
648397 General observation, No Abnormality Detected
0-35,42-77
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forepaw, Right
84-93
DuPont-6554
572
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Dav Oral Gavase Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
F IV
548397 Sacrificed by design
93
F IV
648364 General observation, No Abnormality Detected
0,35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forepaw, Bilateral
7-28
Sacrificed by design
93
F IV
648408 General observation, No Abnormality Detected
0-35,42-77
Eye Observations, Bled via Orbital for Clin Path, Bilateral
93
Eye Observations, Bled via Orbital for Clin Path, Right
39
Hyperactive
84-93
Hyperreactive
84
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F IV
648402 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F IV
648424 General observation, No Abnormality Detected
0-35,42-56,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
)
DuPont-6554
573
Company Sanitized. Does not contain TSCA CBS
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________
Sex Group Animal
F IV
648424
F IV
648390
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Hyperactive
63-77
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Left
0
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
) DuPont-6554
574 Company Sanitized. Does notcontain TSCA CBt
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______________________________________________________________________________________________
Sex Group Animal
F VI
648433
F VI
648406
F VI
648441
F VI
648414
F VI
648366
F VI
648382
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
General observation. No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation. No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation. No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
DuPont-6554
575
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
F VI
648382
F VI
648345
F VI
648374
F VI
648403
F VI
648429
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-15
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Bilateral
21-35,42-56
Hair Loss, Forepaw, Bilateral
84-93
Misshapen Observations, Ear, Right
28-35,42-77,84-93
Sacrificed by design
93
General observation, No Abnormality Detected
0-15
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Bilateral
21-35,42-77,84-93
Sacrificed by design
93
General observation. No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
93
Eye Observations, Bled via Orbital for Clin Path, Right
39
No Ophthalmological Abnormalities Detected
81
) DuPont-6554
576
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____________________
_________________________________ _____ __________________ DuPont-6554
Individual Clinical and Ophthalinological Observations and Mortality Records
Sex Group Animal Observation
Days
F VI
648429 Sacrificed by design
93
F VI
648384 General observation, No Abnormality Detected
0,7,15-84,91
Eye Observations, Closed, Right
147-161,168-183
Eye Observations, Partially Closed, Right
113,119-126,133-140
Eye Observations, Exophthalmus, Right
98.105
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,97,102,109,116,127,141,162,183
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93
Eye Observations, Corneal Opacity, Right
126,133-140
Eye Observations, Dark, Right
98.105
Discharge, Eye right, Black
98.105
Hair Loss, Face, Right
105,113,119
Swollen Observations, Face
105,113
Sacrificed by design VI 648352 General observation, No Abnormality Detected
183
0,7,15-84,91,98,105,113,119-126, 133-140,147
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141
Mass Perineum, Mass #1, Not Ulcerated, 8.0 cm
161
Mass Perineum, Mass #1, Not Ulcerated, 6.0 cm
154
Sacrificed in extremis VI 648365 General observation, No Abnormality Detected
161
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162, 183
577
Company SsiHizsd. Do@snot contato TSCA CM
) ))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats________________________________________________________________________ _______ _______________________ DuPont-6554
Sex Group Animal
F VI
648365
F VI
648413
F VI
648385
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Sacrificed by design General observation, No Abnormality Detected
183
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162 183
Sacrificed by design
183
General observation, No Abnormality Detected
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162 183
Sacrificed by design
183
578
QomP*airSanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal F VIII 648380
F VIII 648381 F VIII 648432 F VIII 648440 F VIII 648348 F VIII 648417
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design General observation, No Abnormality Detected
93 0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
DuPont-6554
579 Conpany Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
F VIII 648417 No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F VIII 648368 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F VIII 648401 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F VIII 648362 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F VIII 648354 General observation, No Abnormality Detected
0-35,42-70,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
Eye Observations, Bled via Orbital for Clin Path, Right
93
Hyperactive
77
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
F VIII 648349 General observation, No Abnormality Detected
0,7,15-84,91,98
Eye Observations, Exophthalmus, Left
147-161,168-175
Eye Observations, Bled via Orbital for Clin Path, Bilateral
56,77
DuPont-6554
580
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________________ ___________________________________
DuPont-6554
Sex Group Animal F VIII 648349 F VIII 648415
F VIII 648379 F VIII 648386
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right
0
3,9,21,35,88,93,97,102,109,116,127,141,162, 183
Eye Observations, Corneal Opacity, Left
105,113,119-126,133-140,147-161, 168-183
Sacrificed by design
183
General observation, No Abnormality Detected
0,7,15-84
Eye Observations, Partially Closed, Right
161,168-183
Eye Observations, Enophthalmus, Right
113.119- 126,133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,9,21,35,56,77,93,97,102,109,183
Eye Observations, Bled via Orbital for Clin Path, Right
3,88,116,127,141,162
Eye Observations, Corneal Opacity, Right
91.98.105.113.119- 126,133-140, 147-161,168-183
Discharge, Eye left, Black
91
Sacrificed by design
183
General observation, No Abnormality Detected
0,7,15-63,84,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,21,35,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,88,93,97,102,109,116,127,141,162,183
Discharge, Eye left, Black
70-77,91
Sacrificed by design
183
General observation, No Abnormality Detected
0
Eye Observations, Closed, Bilateral
182-183
Eye Observations, Closed, Left
35-84,91,97-154
Eye Observations, Partially Closed, Bilateral
161-175
581
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
F VIII 648386 Eye Observations, Partially Closed, Left
21-28
Eye Observations, Partially Closed, Right
113-154
Eye Observations, Enophthalmus, Left
15
Eye Observations, Exophthalmus, Left
7
Eye Observations, Exophthalmus, Right
98-109
Eye Observations, Bled via Orbital for Clin Path, Bilateral
0
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,56,77,88,93
Eye Observations, Corneal Opacity, Right
98-175
Eye Observations, tail vein bled 8/31/01
109
Discharge, Eye right. Black
98-109
Hair Loss, Face, Left
15-63
Hair Loss, Face, Right
105-133
Wound, Superficial, Tail
109-183
Wound, Superficial, Face
15-35
Comments, vein bled 10/2/01
141
Comments, tail vein bled on 10/23/01
162
Comments, animal was tail vein bled, obs was not recorded.
97
Comments, 9/7/01, tailvein bled
116
Comments, 8/31/01 tail vein bled Comments, 8/24/01 eyes not bled, tail vein bled instead.
109 102
Sacrificed by design
183
F VIII 648360 General observation, No Abnormality Detected
0,7,15-84,91,98,105,113,119-126,133-140
Eye Observations, Exophthalmus, Left
147-183
582 Company Sanitized.
008oIcontain TSCA CB!
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Sex Group Animal F VIII 648360
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Eye Observations, Bledvia Orbital for Clin Path, Bilateral
183
Eye Observations, Bledvia Orbital for Clin Path, Left
0,9,56,77
Eye Observations, Bledvia Orbital for Clin Path, Right
3,21,35,88,93,97,102,109,116,127,141
Sacrificed by design
183
>> contain T8CA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Sex Group Animal
FX
648407
FX
648392
FX
648435
FX
648376
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
General observation, No Abnormality Detected T
0-35,42,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39.93
Hyperactive
49-77
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation, No Abnormality Detected
0-35,42-49
Eye Observations, Bled via Orbital for Clin Path, Right
39.93
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Bilateral
56-77,84-93
Hair Loss, Forepaw, Bilateral
70-77,84-93
Sacrificed by design
93
General observation. No Abnormality Detected
0-15
Eye Observations, Bled via Orbital for Clin Path, Right
39.93
Hyperreactive
21-35,42-77,84-93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
General observation. No Abnormality Detected
0-15,21-35,42-49,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39.93
Hyperactive
56-77
No Ophthalmological Abnormalities Detected
81
Comments, compound evident on mouth
18
DuPont-6554
584
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
FX
648376 Sacrificed by design
93
FX
648347 General observation, No Abnormality Detected
0-21
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forepaw, Bilateral
28-35,42-77,84-93
Hair Loss, Shoulder, Right
49-77
Sacrificed by design
93
FX
648412 General observation, No Abnormality Detected
0-15
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forellmb, Bilateral
21-35,42-77,84-93
Hair Loss, Hindlimb, Left
42-77
FX
648438
Sacrificed by design General observation, No Abnormality Detected
93 0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
FX
648400
Sacrificed by design General observation, No Abnormality Detected
93 0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
FX
648388
Sacrificed by design General observation, No Abnormality Detected
93 0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
39
DuPont-6554
585
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______________________
___________________________________ ________ _____ DuPont-6554
Sex Group Animal
FX
648388
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Eye Observations, Bled via Orbital for Clin Path, Right
93
No Ophthalmological Abnormalities Detected
81
FX
648373
Sacrificed by design General observation. No Abnormality Detected
93 0,7,15-28,84,91,98
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162 183
Hair Loss, Forepaw, Bilateral
35-56
Hair Loss, Forepaw, Right
63-77
Hair Loss, Shoulder, Right
70-77,105,113,119-126,133-140, 147-161,168-183
Hair Loss, Face, Right
35-56
Hair Loss, Head, Cranial
113,119
Wound, Superficial, Head
105
FX
648358
Sacrificed by design General observation, No Abnormality Detected
183
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Bilateral
93
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77,97
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,102,109,116,127,141,162,183
FX
648367
Sacrificed by design General observation, No Abnormality Detected
183
0,7,15-84,91,98,105,113,119-126, 133-140,147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162 183
586
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Sex Group Animal
FX
648367
FX
648391
FX
648411
FX
648355
Individual Clinical and Ophthalmological Observations and Mortality Records
Observation
Days
Sacrificed by design
183
General observation, No Abnormality Detected
0,7,15-56
Eye Observations, Closed, Left
70-84,91,98,105,113,119,161,168-183
Eye Observations, Partially Closed, Left
126.133-
140,147-154
Eye Observations, Enophthalmus, Left
126.133-140,147-154
Eye Observations, Exophthalmus, Left
63
Eye Observations, Bled via Orbital for Clin Path, Left
0,56
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,77,88,93,97,102,109,116,127,141, 162,183
Eye Observations, Dark, Right
147-161,168-183
Discharge, Nose, Black
70-77
Hair Loss, Face, Left
70-77
Hair Loss, Nose
182-183
Scab, Head
84,91
Wound, Superficial, Eyelid, Left
63
Wound, Superficial, Face
77
Sacrificed by design
183
General observation. No Abnormality Detected
0,7,15-84,91,105,113,119-126,133-140, 147-161,168-183
Eye Observations, Bled via Orbital for Clin Path, Left
0,56,77
Eye Observations, Bled via Orbital for Clin Path, Right
3,9,21,35,88,93,97,102,109,116,127,141,162, 183
Eye Observations, Dark, Right
98
Sacrificed by design
183
General observation, No Abnormality Detected
0-77,84-122
587
Company Sanitized. Does not contain TSCA CB1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality
Sex Group Animal Observation
Days
FX
648355 Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
FX
648387
Sacrificed by design General observation, No Abnormality Detected
122 0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
FX
648419 General observation, No Abnormality Detected
0,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
Hyperactive
70-77
No Ophthalmological Abnormalities Detected
81
Hair Loss, Forelimb, Left
49-63
Hair Loss, Forepaw, Bilateral
35-63
Hair Loss, Forepaw, Left
7-28
Sacrificed by design
122
FX
648378 General observation, No Abnormality Detected
0-63,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
Hyperactive
70-77
Retina, Retinal Degeneration Focal, Right
81
FX
648398
Sacrificed by design General observation, No Abnormality Detected
122 0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
DuPont-6554
588
Company Sanitized. Does not contain TSCA CBI
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Individual Clinical and Ophthalmological Observations and Mortality Records
Sex Group Animal Observation
Days
FX
648398 Sacrificed by design
122
FX
648350 General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
FX
648383
Sacrificed by design General observation, No Abnormality Detected
122 0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
FX
648359 General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
FX
648375 General observation, No Abnormality Detected
0
Found dead in cage.
5
FX
648399 General observation, No Abnormality Detected
0-77,84-122
Eye Observations, Bled via Orbital for Clin Path, Right
122
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
122
FX
648363 General observation, No Abnormality Detected
0-35,42-77,84-93
Eye Observations, Bled via Orbital for Clin Path, Bilateral
0
Eye Observations, Bled via Orbital for Clin Path, Right
39,93
No Ophthalmological Abnormalities Detected
81
Sacrificed by design
93
) DuPont-6554
589
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIX F INDIVIDUAL OPHTHALMOLOGY EXAMINATION REPORT
Abbreviations: OS - Ocular Sinister - Left eye OD - Ocular Dexter - Right eye
590
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
NANCY ML BROMBERG, V.M .D., M .S.
EYE CLINIC FOR ANIMALS 6119 MASSACHUSETTS AVE
BETHESDA, MB 20816
STUDY INFORMATION: Study Ni H# 24678' Species: Rat Study Director: Don Delker
aitdlV)
OPHTHALMOLOGICAL EXAMINATION SUMMARY Examination Date: August 3,2001 Test Day: 81
METHODS: Indirect Ophthalmoscopy following 1% Tropicamide mydriasis
Sex
Group# Cage#
Observation
M ale
I
109 Focal retinal degeneration OS
V 508 Focal retinal degeneration OS
Fem ale
X
1019
Focal retinal degeneration OD
COMMENTS/DISCUSSION Three (3) animals were identified with ophthalmoscopic lesions, two (2) males and one
(1) female. AS three had ibcai areas o f retinal degeneration in one eye, which is probably due to trauma to the orbit and/or globe during previous orbital sinus bleeding.
No compound related abnormalities were identified.
N/ibcy MUSrojnberg, V .M .D ,,M .S. Diplomate, A.C.V.O.
frate
591
Company Sanitized. Does not contain TSCA CBI
/"N,
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIX G INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS
592
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS EXPLANATORY NOTES
Study Design
Group Male Female Dosage
I II 0 mg/kg/day m IV 60 mg/kg/day V VI 10 mg/kg/day VII v in 60 mg/kg/day rx X 300 mg/kg/day
Test Substance Vehicle control Isopropanol control H-24678 H-24678 H-24678
Footnotes
a One rat died prior to the week 13 evaluation.
Abbreviations
... No data
593
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS
BASELINE
FORELIMB GRIP STRENGTH ( k s )
HINDLIMB GRIP STRENGTH (kg)
Animal Number
Trial 1 Trial 2 Trial 3
Mean of
Mean of
Trials________Trial 1 Trial 2 Trial 3 Trials
Group I: 0 mg/kg/day
648216 0.61 0.76 0.51 648222 0.53 0.72 0.59 648233 0.52 0.47 0.74 648250 0.47 0.61 0.64 648257 0.42 0.65 0.56 648260 0.70 0.66 0.71 648264 0.85 0.88 0.88 648271 0.58 0.58 0.57 648278 0.55 0.62 0.76 648311 0.91 0.58 0.53
0.63 0.61 0.58 0.57 0.54 0.69 0.87 0.58 0.64 0.67
0.22 0.18 0.25 0.19 0.31 0.31 0.44 0.26 0.26 0.27 0.26 0.32 0.21 0.19 0.31 0.30 0.22 0.22 0.30 0.33 0.32 0.38 0.26 0.37 0.28 0.44 0.28 0.17 0.27 0.21
0.22 0.27 0.32 0.28 0.24 0.25 0.32 0.34 0.33 0.22
Group III: 60 mg/kg/day Isopropanol
648227 0.90 0.67 0.85 648232 0.34 0.54 0.97 648252 0.47 0.70 0.53 648258 0.41 0.40 0.65 648269 0.29 0.68 0.62 648274 0.45 0.80 0.71 648290 0.51 0.73 0.79 648299 0.54 0.44 0.61 648302 0.30 0.66 0.68 648303 0.76 0.89 0.65
0.81 0.62 0.57 0.49 0.53 0.65 0.68 0.53 0.55 0-77
0.43 0.36 0.33 0.27 0.30 0.20 0.24 0.18 0.17 0.37 0.36 0.32 0.51 0.27 0.27 0.28 0.22 0.32 0.20 0.25 0.41 0.22 0.31 0.30 0.30 0.46 0.36 0.19 0.33 0.43
0.37 0.26 0.20 0.35 0.35 0.27 0.29 0.28 0.37 0.32
Group V: 10 mg/kg/day
648221 0.70 0.88 0.80 648224 0.56 0.57 0.72 648245 0.99 0.95 0.68 648273 0.44 0.81 0.82 648286 0.74 0.77 0.58 648288 0.50 0.50 0.51 648301 0.43 0.43 0.63 648309 0.59 0.47 0.42 648312 0.76 0.75 0.59 648313 0.57 0.43 0.85
0.79 0.62 0.87 0.69 0.70 0.50 0.50 0.49 0.70 0.62
0.24 0.20 0.21 0.48 0.26 0.58 0.27 0.20 0.26 0.33 0.17 0.31 0.43 0.41 0.47 0.20 0.30 0.41 0.19 0.27 0.20 0.24 0.21 0.13 0.12 0.23 0.25 0.25 0.26 0.19
0.22 0.44 0.24 0.27 0.44 0.30 0.22 0.19 0.20 0.23
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS
___________________________________________ BASELINE________________________________
FOREUMB GRIP STRENGTH (kg)
HTNDLIMB GRIP STRENGTH (kgt
Animal Number
Trial 1 Trial 2 Trial 3
Mean of Trials
Mean of Trial 1 Trial 2 Trial 3 Trials
Group VII: 60 mg/kg/day
648223 0.59 0.71 0.42 648237 0.51 0.64 0.49 648243 0.53 0.54 0.62 648244 0.58 0.60 0.63 648259 0.94 0.67 0.71 648266 0.43 0.55 0.49 648270 1.02 0.86 0.90 648280 0.49 0.70 0.67 648300 0.63 0.67 0.75 648305 0.63 0.81 0.83
0.57 0.55 0.56 0.60 0.77 0.49 0.93 0.62 0.68 0.76
0.42 0.24 0.39 0.15 0.21 0.28 0.19 0.17 0.17 0.16 0.22 0.27 0.18 0.26 0.22 0.25 0.33 0.38 0.41 0.49 0.46 0.34 0.37 0.44 0.26 0.22 0.35 0.21 0.29 0.32
0.35 0.21 0.18 0.22 0.22 0.32 0.45 0.38 0.28 0.27
Group IX: 300 mg/kg/day
648230 0.71 0.67 0.43 648231 0.59 0.86 0.73 648241 0.71 0.62 0.53 648249 0.55 0.68 0.90 648261 0.71 0.74 0.70 648262 0.60 0.61 0.55 648277 0.61 0.72 0.51 648282 0.66 0.68 0.56 648284 0.59 0.56 0.55 648306 0.81 0.91 0.66
0.60 0.73 0.62 0.71 0.72 0.59 0.61 0.63 0.57 0.79
0.39 0.24 0.41 0.42 0.34 0.27 0.30 0.41 0.39 0.36 0.52 0.60 0.23 0.39 0.34 0.15 0.18 0.34 0.17 0.21 0.31 0.25 0.29 0.41 0.27 0.22 0.29 0.23 0.27 0.18
0.35 0.34 0.37 0.49 0.32 0.22 0.23 0.32 0.26 0.23
595 nnf
C o m o ganifeed. Do8
TSC A CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS
WEEK 13
FORELIMB GRIP STRENGTH (kg'!
HINDLTMB GRIP STRENGTH (kg)
Animal Number
Trial 1 Trial 2 Trial 3
Mean of Trials
Mean of Trial 1 Trial 2 Trial 3 Trials
Group I: 0 mg/kg/day
648216 1.32 1.37 1.24
648222 1.10 1.65 0.67
648233 0.97 1.35 1.28
648250 1.80 1.11 1.29
648257 0.70 1.15 0.72
648260 0.75 0.94 1.23
648264 1.68 1.63 1.65
648271 1.33 1.64 0.91
648278 2.34 1.74 2.27
648311 1.30
0.95
1.16
Group III: 60 mg/kg/day Isopropanol
1.31 1.14 1.20 1.40 0.86 0.97 1.65 1.29 2.12 U4
0.57 0.28 0.38 0.42 0.44 0.34 0.33 0.42 0.45 0.32 0.57 0.51 0.57 0.28 0.30 0.41 0.35 0.33 0.62 0.66 0.41 0.38 0.36 0.31 0.49 0.66 0.57 0.42 0.42 0.43
0.41 0.40 0.40 0.47 0.38 0.36 0.56 0.35 0.57 0.42
648227 2.07 2.07 1.12 648232 0.99 0.96 0.85 648252 1.62 1.26 1.32 648258 1.41 1.08 1.56 648269 1.44 1.10 1.37 648274 1.84 1.97 1.46 648290 0.86 0.92 0.67 648299 1.83 1.77 1.76 648302 1.32 1.30 0.98 648303 2.47 1.51 1.89
1.75 0.93 1.40 1.35 1.30 1.76 0.82 1.79 1.20 1.96
0.78 0.73 0.59 0.35 0.55 0.29 0.23 0.24 0.38 0.56 0.27 0.39 0.51 0.50 0.53 0.38 0.62 0.57 0.30 0.55 0.45 0.83 0.91 0.51 0.32 0.41 0.46 0.63 0.45 0.71
0.70 0.40 0.28 0.41 0.51 0.52 0.43 0.75 0.40 0.60
Group V: 10 mg/kg/day
648221 1.24 1.67 1.72 648224 1.50 1.24 1.35 648245 1.30 1.37 1.27 648273 1.48 1.23 1.21 648286 1.92 1.20 1.08 648288 1.24 1.10 1.47 648301 1.24 1.75 1.85 648309 1.67 1.05 1.68 648312 1.95 1.66 1.84 648313 1.73 1.69 1.37
1.54 1.36 1.31 1.31 1.40 1.27 1.61 1.47 1.82 1.60
0.42 0.53 0.47 0.52 0.60 0.50 0.67 0.72 0.63 0.42 0.46 0.36 0.42 0.60 0.59 0.41 0.49 0.47 0.54 0.50 0.57 0.53 0.35 0.42 0.30 0.33 0.40 0.21 0.45 0.53
0.47 0.54 0.67 0.41 0.54 0.46 0.54 0.43 0.34 0.40
596
com TM s - M - B * " *>
TSCA CW
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS
WEEK 13
FORELIMB GRIP STRENGTH ( k s )
HINDLIMB GRIP STRENGTH fksrl
Animal Number
Trial 1 Trial 2 Trial 3
Mean of Trials
Mean of Trial 1 Trial 2 Trial 3 Trials
Group VII: 60 mg/kg/day
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
1.19 1.56 0.90 1.02 1.56 1.37 1.38 1.80 1.24 1.48
1.38 1.21 1.44 1.24 1.30 1.15 0.87 1.09 1.24 1.15
Group IX: 300 mg/kg/day
0.89 1.44 1.42 0.26 1.34 1.23 0.85 0.48 1.42 0.56
1.15 1.40 1.25 0.84 1.40 1.25 1.03 1.12 1.30 1.06
0.39 0.36 0.57 0.44 0.34 0.38 0.42 0.24 0.30 0.49 0.44 0.48 0.37 0.50 0.60 0.70 0.70 0.55 0.58 0.58 0.51 0.42 0.36 0.39 0.50 0.48 0.66 0.34 0.29 0.39
0.44 0.39 0.32 0.47 0.49 0.65 0.56 0.39 0.55 0.34
648230 2.36 1.68 0.96
648231
a
648241 1.22 1.15 1.29
648249 1.10 0.96 0.71
648261 1.58 1.48 1.35
648262 0.91
1.54 0.79
648277 1.00 1.07 1.45
648282 1.28 0.90 0.80
648284 1.31 1.19 1.55
648306 1.78 1.99 2.04
1.67
1.22 0.92 1.47 1.08 1.17 0.99 1.35 1.94
0.40 0.58 0.49
0.48 0.47 0.53 0.31 0.29 0.26 0.33 0.39 0.40 0.30 0.24 0.25 0.45 0.27 0.44 0.32 0.23 0.34 0.38 0.47 0.34 0.41 0.57 0.41
0.49
0.49 0.29 0.37 0.26 0.39 0.30 0.40 0.46
597
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS
BASELINE
FORELIMB GRIP STRENGTH (kg)
HINDLIMB GRIP STRENGTH ike)
Animal Number
Mean of
Trial 1 Trial 2 Trial 3
Trials
Mean of Trial 1 Trial 2 Trial 3 Trials
Group II: 0 mg/kg/day
648346 648389 648394 648404 648425 648426 648427 648434 648439 648442
0.52 0.43 0.31 0.60 0.31 0.36 > 0.34 0.63 0.41 0.96
0.51 0.65 0.52 0.91 0.48 0.61 0.41 0.82 0.64 0.87
0.74 0.63 0.43 0.59 0.50 0.91 0.47 0.67 0.46 0.98
Group IV: 60 mg/kg/day Isopropanol
0.59 0.57 0.42 0.70 0.43 0.63 0.41 0.71 0.50 0.94
0.16 0.25 0.27 0.17 0.26 0.15 0.19 0.30 0.17 0.31 0.36 0.41 0.46 0.35 0.24 0.22 0.27 0.37 0.28 0.38 0.42 0.16 0.17 0.23 0.22 0.28 0.47 0.36 0.36 0.45
0.23 0.19 0.22 0.36 0.35 0.29 0.36 0.19 0.32 0.39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
0.58 0.70 0.39 0.32 0.49 0.21 0.25 0.74 0.34 0.51
0.41 0.81 0.66 0.45 0.52 0.35 0.34 0.53 0.31 0.61
Group VI: 10 mg/kg/day
0.49 0.72 0.49 0.68 0.77 0.40 0.49 0.56 0.23 0.77
0.49 0.74 0.51 0.48 0.59 0.32 0.36 0.61 0.29 0.63
0.19 0.27 0.24 0.37 0.32 0.54 0.15 0.16 0.16 0.30 0.32 0.21 0.22 0.36 0.38 0.18 0.22 0.22 .0.11 0.14 0.16 0.39 0.20 0.36 0.22 0.24 0.28 0.14 0.35 0.37
0.23 0.41 0.16 0.28 0.32 0.21 0.14 0.32 0.25 0.29
648345 0.69 0.57 0.45 648366 0.31 0.41 0.43 648374 0.41 0.44 0.48 648382 0.59 0.40 0.55 648403 0.43 0.47 0.40 648406 0.21 0.33 0.45 648414 0.41 0.66 0.80 648429 0.47 0.59 0.51 648433 0.40 0.40 0.33 648441 0.72 0.54 0.73
0.57 0.38 0.44 0.51 0.43 0.33 0.62 0.52 0.38 0.66
0.35 0.34 0.35 0.22 0.42 0.18 0.34 0.50 0.43 0.25 0.23 0.29 0.19 0.27 0.22 0.28 0.24 0.23 0.43 0.26 0.24 0.17 0.32 0.27 0.29 0.28 0.25 0.39 0.32 0.37
0.35 0.27 0.42 0.26 0.23 0.25 0.31 0.25 0.27 0.36
598
Company Sanitized. P ees not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND fflNDLIM B GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS
BASELINE
FORELIMB GRIP STRENGTH (kg')
HINDLIMB GRIP STRENGTH fkel
Animal Number
Trial 1 Trial 2 Trial 3
Mean of
Mean of
Trials________Trial 1 Trial 2 Trial 3 Trials
Group VIII: 60 mg/kg/day
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
0.70 0.43 0.51 0.60 0.69 0.56 0.65 0.68 0.40 0.46
0.61 0.31 0.69 0.96 0.61 0.71 0.47 0.89 0.51 0.63
Group X: 300 mg/kg/day
0.62 0.27 0.84 0.93 0.89 0.80 0.61 0.84 0.62 0.66
0.64 0.34 0.68 0.83 0.73 0.69 0.58 0.80 0.51 0.58
0.23 0.38 0.32 0.34 0.44 0.24 0.23 0.19 0.21 0.23 0.29 0.36 0.17 0.33 0.22 0.37 0.34 0.33 0.13 0.16 0.27 0.27 0.40 0.39 0.27 0.31 0.44 0.18 0.22 0.22
0.31 0.34 0.21 0.29 0.24 0.35 0.19 0.35 0.34 0.21
648350 0.50 0.85 0.45 648355 0.34 0.52 0.44 648359 0.75 0.80 0.63 648375 0.53 0.47 0.67 648378 1.00 0.62 0.72 648383 0.32 0.69 0.66 648387 0.58 0.64 0.70 648398 0.39 0.64 0.53 648399 0.48 0.89 0.71 648419 0.44 0.54 0.46
0.60 0.43 0.73 0.56 0.78 0.56 0.64 0.52 0.69 0.48
0.16 0.23 0.24 0.26 0.23 0.24 0.46 0.37 0.47 0.22 0.22 0.35 0.22 0.44 0.31 0.25 0.25 0.28 0.43 0.33 0.36 0.30 0.29 0.45 0.17 0.24 0.14 0.24 0.29 0.32
0.21 0.24 0.43 0.26 0.32 0.26 0.37 0.35 0.18 0.28
599
Company Sanitized. Does not contain TSCA CB!
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS
WEEK 13
FORELIMB GRIP STRENGTH tkel
HINDLIMB GRIP STRENGTH (kg)
Animal Number
Trial 1 Trial 2 Trial 3
Mean of Trials
Mean of Trial 1 Trial 2 Trial 3 Trials
Group II: 0 mg/kg/day
648346 1.73 1.22 1.13 648389 0.37 0.22 0.14 648394 0.80 1.24 0.63 648404 1.58 1.58 1.34 648425 0.80 1.19 1.39 648426 1.63 1.72 1.75 648427 1.50 1.42 1.33 648434 1.17 0.61 0.92 648439 1.41 1.00 0.57 648442 1.74 1.11 1.24
Group IV: 60 mg/kg/day Isopropanol
1.36 0.24 0.89 1.50 1.13 1.70 1.42 0.90 0.99 1.36
0.42 0.66 0.44
0.51
0.48 0.31 0.36
0.38
0.32 0.22 0.42
0.32
0.80 0.59 0.56 0.65
0.31 0.31 0.18 0.27
0.37 0.32 0.31
0.33
0.63 0.48 0.55
0.55
0.25 0.48 0.36 0.36
0.52 0.45 0.65
0.54
0.73 0.64 0.58 0.65
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
1.02 1.28 1.42 1.12 1.34 0.57 0.68 0.99 1.03 1.05
0.96 1.09 1.10 1.05 1.39 1.24 0.77 0.58 1.20 1.55
Group VI: 10 mg/kg/day
1.19 1.33 1.11 1.01 0.92 0.83 0.86 0.48 1.50 1.14
1.06 1.23 1.21 1.06 1.22 0.88 0.77 0.68 1.24 1.25
0.47 0.44 0.48 0.46
0.48 0.46 0.43
0.46
0.27 0.27 0.42 0.32
0.53 0.45 0.42 0.47
0.31 0.32 0.24 0.29
0.38 0.33 0.47
0.39
0.41 0.39 0.27 0.36
0.45 0.29 0.36 0.37
0.33 0.34 0.35
0.34
0.50 0.29 0.46 0.42
648345 0.65 0.95 0.80 648366 0.75 1.20 0.93 648374 1.82 1.05 1.36 648382 1.51 0.80 0.60 648403 1.39 1.59 0.98 648406 0.92 0.97 0.74 648414 0.94 0.62 0.92 648429 0.78 1.30 1.06 648433 1.56 1.17 1.08 648441 1.09 1.40 1.23
0.80 0.96 1.41 0.97 1.32 0.88 0.83 1.05 1.27 1.24
0.37 0.51 0.41 0.51 0.32 0.43 0.47 0.50 0.33 0.51 0.32 0.48 0.38 0.42 0.51 0.38 0.36 0.54 0.39 0.42 0.48 0.44 0.28 0.30 0.37 0.55 0.56 0.47 0.37 0.50
0.43 0.42 0.43 0.44 0.44 0.43 0.43 0.34 0.49 0.45
600
Company Sanitized. Does not contain TSC CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS
WEEK 13
FORELIMB GRIP STRENGTH fkel
HINDLIMB GRIP STRENGTH ( k e )
Animal Number
Trial 1 Trial 2 Trial 3
Mean of Trials
Mean of Trial 1 Trial 2 Trial 3 Trials
Group VIII: 60 mg/kg/day
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
1.46 0.74 1.44 1.56 0.97 1.20 0.92 0.80 1.08 1.44
1.72 0.69 1.42 1.36 0.46 1.30 1.12 0.61 0.71 1.49
Group X: 300 mg/kg/day
1.64 1.24 0.97 0.75 1.13 1.06 0.78 1.14 0.67 1.24
1.61 0.89 1.28 1.22 0.85 1.19 0.94 0.85 0.82 1.39
0.59 0.69 0.61 0.42 0.27 0.27 0.67 0.36 0.52 0.49 0.37 0.51 0.76 0.46 0.45 0.56 0.51 0.50 0.23 0.28 0.39 0.46 0.56 0.56 0.50 0.70 0.47 0.24 0.21 0.34
0.63 0.32 0.52 0.46 0.56 0.52 0.30 0.53 0.56 0.26
648350 1.36 1.30 1.24
648355 1.20 0.27 0.22
648359 1.05 1.29 1.13
648375
a
648378 1.31 1.01 0.77
648383 0.88 1.11 1.35
648387 1.22 1.14 0.50
648398 0.83 0.60 0.60
648399 1.62 1.26 1.50
648419 0.60
0.88
1.10
1.30 0.56 1.16
1.03 1.11 0.95 0.68 1.46 0.86
0.32 0.48 0.40 0.22 0.30 0.22 0.22 0.32 0.42
0.40 0.25 0.32
0.39 0.38 0.51 0.29 0.43 0.47 0.26 0.38 0.27 0.40 0.39 0.24 0.27 0.32 0.34 0.41 0.37 0.43
0.43 0.40 0.30 0.34 0.31 0.40
601
Company SmtHUod. Does no* contain TSCA CBt
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIX H INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS
602 , ,,.af eonts
.,,,,S?**. ^ 0 6
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS EXPLANATORY NOTES
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY SCORING SYSTEM
MANIPULATIONS IN OPEN FIELD ARENA (FREE ROAMING SPACE)
APPROACH & TOUCH:
-1 = no reaction 0 = normal 1 = increased reaction (jumps away or attacks)
AUDITORY STIMULUS:
-1 55 no reaction 0 = normal reaction (rat flinches or flicks ear) 1 = exaggerated reaction (rat jumps, flips)
TAIL PINCH:
-1 = no response 0 normal (turns toward site) 1 = exaggerated response (vocalizations, rapid turning)
IN MOTOR ACTIVITY MONITOR
PUPILLARY RESPONSE: DEFECATION: URINATION:
0 = present 1 = absent
0 -- absent 1 = present D = diarrhea
0 - absent 1 = present
Abbreviation
... No data collected
Footnote
a One rat died prior to the week 13 evaluation.
/ '" 'N
603
Company Sanitized. Does not contain ISCA GBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS
Animal Number
BASELINE Manipulation
In Motor Activity
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
Group I: 0 mg/kg/day
648216
0
0
0
0
1
1
648222
0
0
0
0
1
1
648233
0
0
0
0
0
1
648250
0
0
0
0
1
1
648257
0
0
0
0
0
1
648260
0
0
0
0
1
1
648264
0
0
0
0
1
1
648271
0
0
0
0
1
1
648278
0
0
0
0
10
648311
0
0
0
0
1
1
Group III: 60 mg/kg/day Isopropanol
648227
0
0
0
0
1
1
648232
0
0
0
0
1
1
648252
0
0
0
0
1
1
648258
0
0
0
0
1
1
648269
0
0
0
0
1
1
648274
0
0
0
0
1
1
648290
0
0
0
0
0
0
648299
0
0
0
0
1
1
648302
0
0
0
0
1
1
648303
0
0
0
0
0
1
Group V: 10 mg/kg/day
648221
0
0
0
0
1
1
648224
0
0
0
0
0
0
648245
0
0
0
0
1
1
648273
0
0
0
0
1
1
648286
0
0
0
0
10
648288
0
0
0
0
1
1
648301
0
0
0
0
1
1
648309
0
0
0
0
1
1
648312
0
0
0
0
0
1
648313
0
0
0
0
0
1
604
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS
Animal Number
BASELINE Manipulation
In Motor Activity
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
Group VII: 60 mg/kg/day
648223
0
0
0
0
0
0
648237
0
0
0
0
1
1
648243
0
0
0
0
1
1
648244
0
0
0
0
1
1
648259
0
0
0
0
1
1
648266
0
0
0
0
1
1
648270
0
0
0
0
1
1
648280
0
0
0
0
1
1
648300
0
0
0
0
1
1
648305
0
0
0
0
0
0
Group IX: 300 mg/kg/day
648230
0
0
0
0
1
1
648231
0
0
0
0
0
1
648241
0
-1
0
0
1
1
648249
0
0
0
0
1
1
648261
0
0
0
0
1
1
648262
0
0
0
0
1
1
648277
0
0
0
0
1
1
648282
0
0
0
0
0
1
648284
0
0
0
0
1
1
648306
0
0
0
0
1
1
605
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS
Animal Number
WEEK 13 Manipulation
In Motor Activitv
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
Group I: 0 mg/kg/day
648216
0
0
0
0
648222
0
0
0
0
648233
0
0
0
0
648250
0
0
0
0
648257
0
0
0
0
648260
0
0
0
0
648264
0
0
0
0
648271
0
0
0
0
648278
0
0
0
0
648311
0
0
0
0
01 11 01 11 00 01 11 01 01 0l
Group III: 60 mg/kg/day Isopropanol
648227
0
0
0
0
0
1
648232
0
0
0
0
1
1
648252
0
0
0
0
0
1
648258
0
0
0
0
0
1
648269
0
0 -1 0
0
1
648274
0
0
0
0
0
1
648290
0
0
0
0
0
1
648299
0
0
0
0
0
1
648302
0
0
0
0
1
1
648303
0
000
0
1
Group V: 10 mg/kg/day
648221
0
0 -1 0
1
1
648224
0
0
0
0
11
648245
0
0
0
0
1
1
648273
0
0
0
0
0
1
648286
0
0
0
0
0
1
648288
0
0
0
0
0
1
648301
0
0
0
0
11
648309
0
0
0
0
11
648312
0
0
0
0
1
1
648313
0
0
0
0
0
1
606
ewpany Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS
Animal Number
WEEK 13 Manipulation
Approach Auditory and Touch Stimulus Tail Pinch
In Motor Activity
Pupillary Response Defecation Urination
Group VII: 60mg/kg/day
648223
0
0
0
0
1
1
648237
0
0
0
0
1
1
648243
0
0
0
0
1
1
648244
0
0
0
0
1
1
648259
0
0
0
0
1
1
648266
0
0
0
0
0
1
648270
0
0
0
0
1
1
648280
0
0
0
0
1
1
648300
0
0
0
0
1
1
648305
0
0
0
0
0
1
Group IX: 300 mg/kg/day
648230
0
0
0
0
1
1
648231
a
648241
0
0
0
0
1
1
648249
0
00 0
0
1
648261
0
0
0
0
1
1
648262
0
000
0
0
648277
0
0
0
0
0
1
648282
0
00 0
1
1
648284
0
0
0
0
1
1
648306
0
000
1
1
607
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS
_______________________________ BASELINE________________________________
Manipulation
In Motor Activity
Animal Approach Auditory
Pupillary
Number and Touch Stimulus Tail Pinch Response Defecation Urination
Group II: 0 mg/kg/day
648346
0
0
0
0
0
1
648389
0
000
0
0
648394
0
0
0
0
1
1
648404
0
0
0
0
1
1
648425
0
0
0
0
0
1
648426
0
0
0
0
0
0
648427
0
0
0
0
1
1
648434
0
0
0
0
0
1
648439
0
0
0
0
1
1
648442
0
0
0
0
0
1
Group IV: 60 mg/kg/day Isopropanol
648364
0
0
0
0
0
1
648369
0
0
0
0
1
1
648390
0
0
0
0
0
1
648396
0
0
0
0
1
I
648397
0
0
0
0
1
1
648402
0
0
0
0
1
1
648408
0
0
0
0
1
1
648409
0
0
0
0
1
1
648410
0
0
0
0
10
648424
0
0
0
0
1
1
Group VI: 10 mg/kg/day
648345
0
0
0
0
1
1
648366
0
0
0
0
1
1
648374
0
0
0
0
10
648382
0
0
0
0
0
1
648403
0
0
0
0
1
1
648406
0
0
0
0
11
648414
0
0
0
0
1
1
648429
0
0
0
0
0
0
648433
0
0
0
0
I
1
648441
0
0
00
0
0
608
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS
Animal Number
BASELINE Manipulation
In Motor Activity
Approach Auditory
Pupillary
and Touch Stimulus Tail Pinch Response Defecation Urination
Group VIII: 60 mg/kg/day
648348
0
0
0
0
0
1
648354
0
0
0
0
0
1
648362
0
0
0
0
0
1
648368
0
0
0
0
10
648380
0
0
0
0
1
1
648381
0
-1
0
0
0
1
648401
0
0
0
0
1
1
648417
0
0
0
0
11
648432
0
0
0
0
1
1
648440
0
0
0
0
10
Group X: 300 mg/kg/day
648350
0
0
0
0
1
1
648355
0
0
0
0
0
0
648359
0
0
0
0
1
1
648375
0
0
0
0
0
0
648378
0
0
0
0
0
1
648383
0
0
0
0
1
1
648387
0
0
0
0
1
1
648398
0
0
0
0
1
1
648399
0
0
0
0
0
1
648419
0
0
0
0
1
1
609
not contain TSCACBI Company Sanflteed. Does
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS
________________________________ WEEK 13_______________________________
Manipulation
In Motor Activity
Animal Approach Auditory
Pupillary
Number and Touch Stimulus Tail Pinch Response Defecation Urination
Group II: 0 mg/kg/day
648346
0
0
0
0
0
1
648389
0
0
0
0
0
1
648394
0
0
0
0
0
1
648404
0
0
0
0
1
0
648425
0
0
0
0
0
1
648426
0
0
0
0
0
1
648427
0
0
0
0
0
1
648434
0
0
0
0
0
1
648439
0
0
0
0
1
1
648442
0
0
0
0
1
1
Group IV: 60 mg/kg/day Isopropanol
648364
0
0
0
0
0
1
648369
0
0
0
0
0
1
648390
0
0
0
0
0
1
648396
0
0
0
0
0
1
648397
0
0
0
0
0
1
648402
0
0
0
0
0
1
648408
0
0
0
0
1
1
648409
0
0
0
0
1
1
648410
0
0
0
0
0
1
648424
0
0
0
0
0
1
Group VI: 10 mg/kg/day
648345
0
0
0
0
1
1
648366
0
0
0
0
0
1
648374
0
0
0
0
1
1
648382
0
0
0
0
1
1
648403
0
0
0
0
0
1
648406
0
0
0
0
1
1
648414
0
0
0
0
0
1
648429
0
0
0
0
1
1
648433
0
0
0
0
1
1
648441
0
0
0
0
1
1
610
Company Sanitized. Does not contain TSCA C3I
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS
Animal Number
WEEK 13 ManiDulation
Approach Auditory and Touch Stimulus Tail Pinch
In Motor Activity
Pupillary Response Defecation Urination
Group VIII: 60 mg/kg/day
648348
0
0
0
0
0
1
648354
0
0
0
0
11
648362
0
0 -1 0
1
1
648368
0
0
0
0
0
1
648380
0
0
0
0
1
1
648381
0
0
0
0
0
1
648401
0
0
0
0
1
1
648417
0
0
0
0
0
1
648432
0
0
0
0
0
1
648440
0
0
0
0
0
1
Group X: 300 mg/kg/day
648350
0
0
0
0
0
1
648355
0
0
0
0
1
1
648359
0
0
0
0
0
1
648375
a
648378
0
0
0
0
1
1
648383
0
0
0
0
1
1
648387
0
0
0
0
0
1
648398
0
0
0
0
0
1
648399
0
0
0
0
1
1
648419
0
0
0
0
1
1
611
Company Sanitized. Does nof frtain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIX I INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT
612
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT EXPLANATORY NOTES
Footnote
a. The sensor did not appear to be working correctly and, therefore, the data were not used. b. One rat died prior to the week 13 evaluation.
613
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
Animal Number
BASELINE
SUCCESSIVE 10-MINUTE INTERVALS I 2 3 4 5 6 Total
Group I: 0 mg/kg/day
648216 288 287 187 201 244
7 1214
648222 371 345 282 154
90
1 1243
648233 365 328 248 48 15
5 1009
648250 432 309 259 251 355 115 1721
648257 435 290 112 0 3 2 842
648260 322 352 327 46 87
4 1138
648264 412 348 259 72 35
0 1126
648271 438 384 286 109
20
4 1241
648278 480 459 326 295
65 115 1740
648311 451 363 333 346 329
13 1835
Group III: 60 mg/kg/day Isopropanol
648227 428 403 285
18
1
2 1137
648232 462 327 291 333
56
0 1469
648252 345 210 269 198
35
3 1060
648258 412 318 192
28
1 39 990
648269 378 300
82
1 27
0 788
648274 463 339 339 353 281 196 1971
648290 444 327 165
20
0 10 966
648299 405 357 333
39
7
5 1146
648302
345 329 273
183
82
24 1236
648303 389 345 347 172
21
1 1275
Group V: 10 mg/kg/day
648221 543 444 232 15 42
9 1285
648224 364 175 6 0 0 0 545
648245 313 233 200
99 217 153 1215
648273 424 362 390 202 106
16 1500
648286 304 208 189 238 292 184 1415
648288 498 251
68
0
0
3 820
648301 412 366 264 202 4 0 1248
648309 328 325 272 228 32 34 1219
648312 404 290 294 232 184
17 1421
648313 377 282 187 26 37
1 910
614
Company Sanitized. Does not contain TSCA CBl
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
Animal Number
BASELINE
Successive 10-Minute Intervals 12 3 4 5
6 Total
Group VII: 60 mg/kg/day
648223 413 342 364
2 65 53 1239
648237 442 381 184
2 133
42 1184
648243 383 387 154 0 7 3 934
648244 484 411 336 388 173
2 1794
648259 471 341 189 0 1 7 1009
648266 482 404 399 240 285 166 1976
648270 370 263 213 241 147
31 1265
648280 297 274 316 211
38
5 1141
648300 371 395 225 218 164
6 1379
648305 363 329 172
0 11
8 883
Group IX: 300 mg/kg/day
648230 372 253 230 179
73
1 1108
648231 416 307
92
0
2 12 829
648241 432 282
86
3
0 52 855
648249 369 323 340 211
14 21 1278
648261 421 366 360
25
0
9 1181
648262 418 233 337 220 51 17 1276
648277 401 362 341 308 167 182 1761
648282 343 236 228
26
7
0 840
648284 399 331 274 83 89
1 1177
648306 382 366 395 293 148
16 1600
615
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
Animal Number
WEEK 13
Successive 10-Minute Intervals I 2 3 4 5 6 Total
Group I: Omg/kg/day
648216 482 447 403 338 335 212 2217
648222 356 222 228 169 124
0 1099
648233 344 104 160 126
61 155 950
648250 457 417 419 283 231 293 2100
648257 435 309 330 291 179
60 1604
648260 334 222 279 140
10
0 985
648264 422 339 354 315 268 300 1998
648271 456 374 369 406 234 274 2113
648278 431 347 322 262 99 20 1481
648311 477 447 355 378 359 262 2278
Group III: 60 mg/kg/day Isopropanol
648227 427 329 291 246 183 289 1765
648232 405 340 303 270 242 113 1673
648252 350 319 218 138
61
0 1086
648258 443 232 244 315
91 137 1462
648269 419 365 374 308 330 231 2027
648274 455 456 284 331 298 230 2054
648290
432
319
232
263
282
184 1712
648299 410 341 346 193 251
57 1598
648302 346 309 345 218 142 192 1552
648303 393 331 309 304 274 341 1952
Group V: 10 mg/kg/day
648221 3 _ _ - _
-
648224 364 302 322 178
40
5 1211
648245 343 285 275 214 246 280 1643
648273 452 336 343 241 208 225 1805
648286 396 326 16 84 291 264 1377
648288
a ---
--
-
648301 361 281 239 252 242 107 1482
648309 387 352 301 196 191 207 1634
648312 416 323 282 301 218 256 1796
648313 362 225 306 134 221
57 1305
616
Company Sanitized. Does not contain TSC CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS
Animal Number
WEEK 13
Successive 10-Minute Intervals 1 2 3 4 5 6 Total
Group VII: 60mg/kg/day
648223 443 354 356 328 306 317 2104
648237 413 266 286 265 204 188 1622
648243 363 321 239 239 221 101 1484
648244 464 389 349 367 310 175 2054
648259 417 381 300 331 343 118 1890
648266 443 369 335 346 286 225 2004
648270 374 316 258 245 177 145 1515
648280 453 315 301 277 266 213 1825
648300 400 324 309 78 28
3 1142
648305 376 330 409 35 25
0 1175
Group IX: 300 mg/kg/day
648230 416 322 365 298 284 162 1847
648231
_b
-
-
---
-
648241 442 434 337 225 292 281 2011
648249 462 349 391 296 122
13 1633
648261 399 351 319 341 243
53 1706
648262 352 265 239
31 ,
6
0 893
648277 429 344 366 279 254 183 1855
648282 354 306 256 260 232 202 1610
648284 363 320 271 247 299 250 1750
648306 341 284 321
175
0 15 1136
617
Company Sanitized. Does not contain TSCA CB1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
Animal Number
BASELINE
Successive 10-Minute Intervals 1 2 3 4 5 6 Total
Group II: 0 mg/kg/day
648346 427 323 110 248 171 101 1380
648389 323 179 187 211 155 206 1261
648394 381 203 234
75 183 347 1423
648404 403 329 317 229 254 203 1735
648425 414 313 254 236 109
21 1347
648426 362 246 224 211 286 302 1631
648427 371 296 293 200 119
74 1353
648434 350 278 131 101 0 6 866
648439 412 136 347 229 243 151 1518
648442 413 314 227 229 10 12 1205
Group IV: 60 mg/kg/day Isopropanol
648364 453 336 203 334 259 321 1906
648369
344 225 234
119
11 184 1117
648390 344 180 246
87 163 187 1207
648396 334 340 377 284 237 290 1862
648397 482 443 380 410 414 428 2557
648402 314 232
82 111 125
6 870
648408 358 221 249 232 322 113 1495
648409 294 287 257 178 176 193 1385
648410 298 218 252 180 214 127 1289
648424 404 424 423 355 362 309 2277
Group VI: 10 mg/kg/day
648345 349 139 183 257 304 321 1553
648366 392 284 262 183 167 100 1388
648374 379 263 187 256 197 124 1406
648382 409 315 279 229
91 205 1528
648403 418 293 165 293 201
9 1379
648406 428 391 365 262 329 294 2069
648414 385 359 311 217 145
17 1434
648429 283 236 178 310 147 179 1333
648433 398 348 376 304 192 194 1812
648441 398 304 186 20 69 52 1029
618
Company Sanitized. Does not contain TSCA OB!
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
Animal Number
BASELINE
Successive 10-Minute Intervals I 2 3 4 5 6 Total
Group Vili: 60 mg/kg/day
648348 449 350 358 299 291 286 2033
648354 384 291 342 279 32 13 1341
648362 392 364 267 213
15
6 1257
648368 333 243 214 231 193 251 1465
648380
351
54
2 138 185
98 828
648381 266 194
69 155 136 112 932
648401 315 219 172 217 236 148 1307
648417 399 302 352 162 190
29 1434
648432 364 313 347 272 259 253 1808
648440
513
466
445
422
258
116 2220
Group X: 300mg/kg/day
648350 348 396 294 371 188 164 1761
648355 350 238 231 254 125 194 1392
648359 545 424 406 391 354 176 2296
648375
332 313
187 200
141
49 1222
648378 303 192 221 118 179 149 1162
648383 368 331 217 176 180 287 1559
648387 303 292 205 238 188 169 1395
648398 371 231
86 137
29
3 857
648399
394 273
125 302 202
3 1299
648419 449 382 319 230 181 113 1674
619
Corapanf Sanitized. Dees not contain TSCACBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
Animal Number
WEEK 13
Successive 10-Minute Intervals I 2 3 4 5 6 Total
Group II: 0 mg/kg/day
648346 469 427 346 275 238 192 1947
648389 365 242 272 194 47 98 1218
648394 350 265 245 217 164 114 1355
648404 438 330 183 203 300 121 1575
648425 378 362 283 257 194 184 1658
648426 425 301 202 229 233
66 1456
648427 398 217 186 214 324 159 1498
648434 378 303 290 250 301 287 1809
648439 386 334 241 242
56 194 1453
648442 436 284 188 175 245 154 1482
Group IV: 60 mg/kg/day Isopropanol
648364 487 434 405 409 436 342 2513
648369 345 337 317 276 215 201 1691
648390 330 221
85
0 116 189 941
648396 467 421
81 260 376 250 1855
648397 528 517 499 295 411 364 2614
648402 439 272 205 162
19 158 1255
648408 465 288 295 230 254 133 1665
648409
350 226
113 202
177
83 1151
648410 382 318 311 81 17 138 1247
648424 517 529 420 470 425 335 2696
Group VI: 10 mg/kg/day
648345 363 372 214 197
38 198 1382
648366 410 277 356 254 240 213 1750
648374 423 349 307 321 112
0 1512
648382 474 436 363 368 333 347 2321
648403 447 285 258 172 32 16 1210
648406 412 329 289 210 118
29 1387
648414 364 347 189
15 168
30 1113
648429 339 317 204 175 104
62 1201
648433 428 397 301 294 273 340 2033
648441 449 271 229 190 219 155 1513
620
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS
Animal Number
WEEK 13
Successive 10-Minute Intervals I 2 3 4 5 6 Total
Group VIII: 60 mg/kg/day
648348 498 417 383 389 319
34 2040
648354 382 287 258 162 178 267 1534
648362 443 441 346 363 238
87 1918
648368 358 287 293 249
98 147 1432
648380 276 240
49 163
3 112 843
648381 364 173 219 25 88 49 918
648401
367 278 219 262 260
142 1528
648417 388 283 272 209 242 239 1633
648432 385 332 351 340 331 217 1956
648440 475 464 396 459 418 410 2622
Group X: 300 mg/kg/day
648350 409 300 250 194 196 112 1461
648355 408 234 163 102
9 213 1129
648359 a - - - - - -
648375
_b
-
-
-
-
-
-
648378 334 253 374 239 291 269 1760
648383 445 382 288 212 270 187 1784
648387 372 289 200 187 197
68 1313
648398 407 303 274 183
36
4 1207
648399 346 354 200 213 153
13 1279
648419 a - - - - - -
621
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIX J INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS
622
Company Sanitized. Does m i contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______________________________________________________________ DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS EXPLANATORY NOTES
Footnotes a. The sensor did not appear to be working correctly and, therefore, the data were not used. b. One rat died prior to die week 13 evaluation.
623
fcompany Sanitized. Dees not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
Animal Number
I
Group I: 0 mg/kg/day
BASELINE
Successive 10-Minute Intervals 234 5
6 Total
648216 143 135 141 120 152
648222 141 136 132 125 103
648233 136 149 165 32 25
648250 107 129 123 139 120
648257 131 131
59
14
648260 154 147 154 49 74
648264 141 151 161 72 26
648271 110 122 134
71
17
648278 112 131 131 137
70
648311 106 124 139 159 148
12 703 8 645 6 513 64 682 3 329 5 583 2 553 20 474 71 652 15 691
Group III: 60 mg/kg/day Isopropanol
648227 123 139 123
17
2
6 410
648232 119 118 135 153
70
0 595
648252 141 137 161 143
20
2 604
648258 118 129 117
17
6 26 413
648269 137 170
66
5 15
0 393
648274 134 155 175 171 165 132 932
648290 132 121 102
12
1 11 379
648299 144 147 153
42
9
7 502
648302 151 151 151 125 62 17 657
648303 147 145 143 102
31
2 570
Group V: 10 mg/kg/day
648221 64 85 60
8 14
4 235
648224 159 117
12
0
1
1 290
648245 122 122 122
71 108
93 638
648273 118 129 117 137 59 19 579
648286 127 127 126 140 123 127 770
648288 68 59 24 0 0 1 152
648301 141 140 140 116 6 0 543
648309 120 142 150 113 38 39 602
648312 115 150 130 141 117
16 669
648313 144 133 118 33 21
5 454
624
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rate
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
Animal Number
I
Group VII: 60mg/kg/day
BASELINE
Successive 10-Minute Intervals 2345
6 Total
648223 124 139 137
6 33
648237 122 151 108
3 82
648243 118 141 103
0 12
648244 102 130 141 126
83
648259 121 140 130 1 3
648266 106 114 126 117 145
648270 161 144 139 122 134
648280 151 144 165 158
36
648300 151 158 137 130 119
648305 112 132 114 3 7
38 477 29 495 7 381 6 588
8 403 84 692 28 728 5 659 9 704 15 383
Group IX: 300mg/kg/day
648230 133 153 127 142
77
5 637
648231 167 160
83
3
5 16 434
648241 127 128
92
4
0 25 376
648249 132 139 172 150 11 29 633
648261 125 132 131
27
0
5 420
648262
139
94 131 117
45
19 545
648277 124 154 145 155 141 137 856
648282 149 143 113 45 10
1 461
648284 138 121 135 58 51
5 508
648306 149 155 142 143 104
22 715
625
Company Sanitized. Does not ontan TSCA CB1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
Animal Number
i
Group I: 0 mg/kg/day
WEEK 13
Successive 10-Minute Intervals 2 34 5
6 Total
648216 117 143 133 131 136
92 752
648222 160 126 145 135
99
2 667
648233
160
94
93 106
43 132 628
648250 108 120 124 127
89 143 711
648257 139 145 163 139 136
58 780
648260 173 127 147
96
9
1 553
648264 140 173 165 158 177 137 950
648271 115 127 136 129 101
99 707
648278 110 140 152 127 66 28 623
648311 108 109 133 115 147 107 719
Group III: 60 mg/kg/day Isopropanol
648227 124 122 110 111
90 127 684
648232 144 147 149 141 106
88 775
648252 134 145 133 73 38
2 525
648258 136 120 129 135
62 102 684
648269 143 165 140 134 171 144 897
648274 145 131 142 177 153 160 908
648290 124 108
98 133 125 104 692
648299 143 152 161 121 134
58 769
648302 151 140 138 101
94 130 754
648303 159 143 155 144 143 130 874
Group V: 10 mg/kg/day
648221 a - - - - - -
648224 134 104 152 90 35
7 522
648245 139 151 142 116 128 162 838
648273 123 141 136 113 125 134 772
648286 648288
136 119 a-
21 50 128 146 600 _- - - -
648301 128 114 108 133 126
67 676
648309 134 145 148 136 129 126 818
648312 138 130 138 128
90 122 746
648313 124 115 117
83 115
30 584
626
Company Sanitized. D o riot contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS
Animal Number
WEEK 13
Successive 10-Minute Intervals I 2 3 4 5 6 Total
Group VII: 60 mg/kg/day
648223 124 127 130 144 144 159 828
648237 137 144 148 130 133 116 808
648243 143 112 105 128 97 69 654
648244 102 129 117 133 127 107 715
648259 109 138 140 146 159
40 732
648266 144 154 148 169 166 158 939
648270 155 176 159 153 146 109 898
648280 124 132 128 139 131 120 774
648300 137 142 162 70 16
6 533
648305 136 117 149 36 28
2 468
Group IX: 300 mg/kg/day
648230 648231
117 122 117 109 131
_b - - - -
102 698
--
648241 115 104 107
87 107 127 647
648249 132 132 154 162 37 18 635
648261 145 142 161 158 127
54 787
648262 139 138 135
14 -
6
1 433
648277 131 163 156 122 130 131 833
648282 159 134 113 134 123 149 812
648284 117 123 128 123 128 132 751
648306 152 160 150 128
1 20 611
627 Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
Animal Number
I
Group II: 0 mg/kg/day
BASELINE
Successive 10-Minute Intervals 2345
6 Total
648346 158 161
57 146 155
86 763
648389 153 139 110 134 109 120 765
648394 114 127 122
52 107 136 658
648404 121 129 146 121 108
99 724
648425 139 150 147 163 93 17 709
648426 126 121 132 149 144 164 836
648427 148 134 141 150 83 67 723
648434 144 148 119
71
1
7 490
648439
115
91 133 119 118
97 673
648442 132 119 122 149 15 27 564
Group IV: 60 mg/kg/day Isopropanol
648364 106 113 112 117 127 168 743
648369 141 168 138 114
6 121 688
648390 153 118 200 112 115 114 812
648396 127 112 109 145 106 130 729
648397 110 136 129 129 115 120 739
648402 144 127 69 88 104
8 540
648408 136 116 108 109 151
97 717
648409 111 105 125 110 133 127 711
648410 129 106 127 126 121
89 698
648424 118 126 133 126 127 144 774
Group VI: 10 mg/kg/day
648345
137
82 105 143 133 152 752
648366 165 152 141 118 123 101 800
648374 137 141 133 148 143 129 831
648382 135 138 141 125
56 125 720
648403 141 139
67 n o 120
14 591
648406 135 137 145 145 153 143 858
648414 159 144 146 143 115
24 731
648429 116 124
98 119 109 128 694
648433 120 128 130 135 106 140 759
648441 109 126 111 25 47 58 476
628
Cam pani Sanitized. Does not contain TSGACBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
Animal Number
I
Group VIII: 60 mg/kg/day
BASELINE
Successive 10-Minute Intervals 2 34 5
6 Total
648348 121 157 129 143 164 110 824
648354 127 142 135 153
29
16 602
648362 129 130 85 108 20 10 482
648368 145 143 147 149 139 147 870
648380
158
49
3 135 112 117 574
648381 151 156
80 110 106
97 700
648401 144 132 111 161 168
88 804
648417 129 144 153 122 132
33 713
648432 126 151 134 150 147 142 850
648440
99 107 117 118 125
79 645
Group X: 300mg/kg/day
648350 121 113 124 115 121 121 715
648355 141 160 135 140 105 113 794
648359 66 61 55 59 67 26 334
648375 134 122 108 109 114
51 638
648378
119
86 118 102 111 113 649
648383 114 111 107
89 101 141 663
648387 119 136 121 118 130 125 749
648398 131 127
98 121
35
7 519
648399 133 126
60 135 124
9 587
648419 114 126 127 123 119
98 707
629
Company Sanitized. Does not contain TSCA C8I
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
Animal Number
1
Group II: Omg/kg/day
WEEK 13
Successive 10-Minute Intervals 234 5
6 Total
648346 141 147 148 149 144 121 850
648389 116 116 135 148 50 64 629
648394 144 123 165 140 123
74 769
648404 115 126 131 126 137
77 712
648425 136 161 138 126 141 132 834
648426 129 134 117 123 135
68 706
648427 133 144 101 123 152 112 765
648434 141 138 136 154 155 123 847
648439 130 111 126 116
58 123 664
648442 130 129 114 120 128
91 712
Group IV: 60 mg/kg/day Isopropanol
648364 121 117 149 159 160 153 859
648369 144 164 161 144 160 141 914
648390 146 127
70
5 104 130 582
648396 125 129 62 98 124 131 669
648397 90 94 92 142 136 140 694
648402 149 133 134 108 26 87 637
648408 125 144 161 140 142 121 833
648409 137 132 117 136 137
65 724
648410 150 164 165 65 25 99 668
648424 85 81 112 116 130 127 651
Group VI: 10 mg/kg/day
648345 135 133 132 133
55 139 727
648366 139 130 151 144 118 131 813
648374 125 149 171 182
91
0 718
648382 127 134 162 160 152 162 897
648403 120 122 129 104 25 15 515
648406 122 141 125 119 74 39 620
648414 129 135 100
20 110
38 532
648429 146 149 133 130 100
67 725
648433 129 142 122 158 156 156 863
648441 144 145 130 105 122 127 773
630
Company Sanitized. Does sot contain TSCACSI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS
Animal Number
i
Group VIII: 60 mg/kg/day
WEEK 13
Successive 10-Minute Intervals 234 5
6 Total
648348 119 125 157 149 135
22 707
648354 142 117 125 65 98 140 687
648362 124 110 119 124 114
89 680
648368 154 165 155 153
73 112 812
648380 133 109
29
95
10 97 473
648381 157 115 141 25 60 64 562
648401 139 124 118 125 141 111 758
648417 140 137 150 146 157 169 899
648432 138 123 160 139 126 135 821
648440 113 107 115 107 111 136 689
Group X: 300 mg/kg/day
648350 131 120 111 115 118
79 674
648355 648359 648375
127 112 a-
_b -
118
-
80 -
8 142 587 -- -
-- -
648378 124 113 139 124 154 128 782
648383 116 135 124 119 159 130 783
648387 133 140 128 114 118
56 689
648398 140 170 151 136
46
10 653
648399 141 130 120 124 107
648419
a -
-
-
-
15 637
-_
631
Cosnpanf Sanitized. Does not contain TSCA C81
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
APPENDIX K INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
632
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
STUDY DESIGN
Group Male Female
I II III IV
V VI VII VIII IX X
Dosage 0 mg/kg/day 60 mg/kg/day 10 mg/kg/day 60 mg/kg/day 300 mg/kg/day
EXPLANATORY NOTES
Test Substance Vehicle control Isopropanol control H-24678 H-24678 H-24678
DuPont-6554
ABBREVIATIONS:
General: ADEQ _ adequate CLOT - sample clotted DECR - decreased NSR - no sample received for testing NT - not taken or not performed OK - sample condition OK for testing QNS - quantity not sufficient for testing RNV - result not valid UTD - unable to determine > - greater than < - less than
individual Hematology Values: COND - sample condition RBC - red blood cell count HGB - hemoglobin HCT - hematocrit MCV - mean corpuscular volume MCH - mean corpuscular hemoglobin MCHC - mean corpuscular hemoglobin concentration RDW - red cell distribution width ARET - absolute reticulocyte count PLT - platelet count WBC - white blood cell count ANEU - absolute neutrophil (all forms) ANPR - absolute neutrophil precursor ALYM - absolute lymphocyte AMON - absolute monocyte AEOS - absolute eosinophil ABAS - absolute basophil ALUC - absolute large unstained cell ABLT - absolute blast leukocyte AMSC - absolute miscellaneous leukocyte SPEC " special observations
Individual Red Blood cell Morphology Values: NORM - normal ANIS - anisocytosis MIC - microcytes MAC - macrocytes POLY - polychromasia HYPO - hypochromasia ECHI - echinocytes ACAN - acanthocytes TARG - target cells RX - rouleaux HJB - Howell-Jolly body SPEC - special observations -- - not observed or not examined; see whole blood sample condition
633
l5omatny Sanitized. Does not contain TSCA OBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES (Continued)
ABBREVIATIONS: (Continued)
Individual White Blood Cell / Platelet Morphology Values: NORM - normal SM - smudge white blood cells TOX - toxic neutrophils DB _ Dhle bodies VC _ vacuolated cytoplasm PCE - platelet clumps / estimate GP - giant platelets BP _ bizarre platelets SPEC - special observations ~ - not observed or not examined; see whole blood sample condition
Individual Coagulation Values: PHEM - plasma hemolysis PLIP - plasma lipemia PICT - plasma icterus PT _ prothrombin time APTT - activated partial thromboplastin time
Individual Serum and Plasma Chemistry Values: SHEM - serum hemolysis SLIP - serum lipemia SICT - serum icterus AST - aspartate aminotransferase ALT - alanine aminotransferase SDH - sorbitol dehydrogenase ALKP - alkaline phosphatase BILI - total bilirubin BUN - urea nitrogen CREA - creatinine CHOL - cholesterol TRIG - triglycerides GLUC - glucose TP - total protein ALB - albumin GLOB - globulin CALC - calcium IPHS - inorganic phosphorous NA - sodium K - potassium CL - chloride PHEM - plasma hemolysis from blood sample for fluoride determination PLIP - plasma lipemia from blood sample for fluoride determination PICT - plasma icterus from blood sample for fluoride determination PFLU - plasma fluoride
634
Company Sanitized. Does not contain T8CA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES (Continued)
ABBREVIATIONS: (Continued)
Individual Urinalysis Values: QUAL - quality (modifies color) COL - color CLAR - clarity VOL - volume UOSM - urine osmolality SG - specific gravity pH - the logarithm of the reciprocal of the hydrogen ion concentration UGLU - urine glucose KET - ketone UBIL - urine bilirubin BLD - blood URO - urobilinogen UFLU - urine fluoride UMTP - urine protein SPEC - special observations
Individual Urine Microscopic Examination Values: EPIT - epithelial cells UWBC - urine white blood cells URBC - urine red blood cells NCRY - normal crystals MICR - microorgani sms SPER - sperm SPEC - special observations
635
Company Sanitized, Poes not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES (Continued)
KEY:
Special Observations: 1 - trace 2 - few 3 - moderate 4 - many
Orine Microscopic Values:
EPIT/UWBC/URBC
NCRY/MICR
SPERM/MUCUS
CASTS
per high power field
per high power field
per low power field per low power field
_________(40x)_____________________ (40x)______________________ (lOx)___________________ (lOx)________
few - 1-10 moderate - 11-50
many - >50
few - 1-25%/field moderate - 26-50%/field
many - >50%/field
1 - 1-5 2 - 6-20 3 - >20
few - 1-10 moderate - 11-50
many - >50
NOTES:
When individual animal data are not reported, it may be due to one of the following reasons or other reasons, all of which are explained in the study records:
the sample was clotted CLOT) there was insufficient sample for testing (QNS) a valid result could not be obtained (RNV) the sample was not suitable for testing the animal died prior to sample collection no sample was available for testing (NSR)
When an individual observation was recorded as being less than a certain value, calculations were performed on half the recorded value. For example, if bilirubin was reported as <0.1, 0.05 was used for any calculations performed with that bilirubin, data.
When an individual observation was recorded as being greater than a certain value, calculations were performed on the recorded value. For example, if specific gravity was reported as >1.083, 1.083 was used for any calculations performed with that specific gravity data.
636
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
COND
RBC
xlO A6/ih
HGB g/dL
Male, Group: I - 0 mg/kg - Day 38
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
OK OK OK OK CLOT CLOT OK NSR OK OK
7.67 8.30 8.02 9.00
NT NT 7.77 NT 7.82 7.92
14.6 15.7 15.0 16.4
NT NT 14.7 NT 15.1 14.6
Male, Group: III - 60 mg/kg - Day 38
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
OK CLOT
OK OK OK CLOT OK OK OK OK
8.18 NT
8.16 8.29 7.97
NT 9.06 8.67 8.54 8.25
14.9 NT
15.0 15.2 14.7
NT 16.0 15.4 15.6 15.4
Male, Group: V - 10 mg/kg - Day 38
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
OK 8.36 15.7 OK 8.16 15.5 OK 7.83 14.7 OK 8.63 14.8 OK 7.60 14.1 OK 8.24 15.0 OK 8.41 15.3 OK 8.29 15.1 OK 7.49 14.4 OK 8.35 15.0
Individual Hematology Values
HCT MCV MCH MCHC % fl. pg g/dL
44.9 50.7 46.7 51.1
NT NT 46.7 NT 47.2 46.0
47.9 NT
46.5 48.4 45.3
NT 52.3 49.6 49.5 48.4
51.6 48.0 46.1 47.3 45.4 48.4 48.0 47.9 44.8 46.9
58.5 61.1 58.1 56.8
NT NT 60.1 NT 60.3 58.1
58.5 NT
57.0 58.5 56.8
NT 57.7 57.3 58.0 58.7
61.7 58.8 58.9 54.8 59.7 58.7 57.0 57.9 59.8 56.2
19.0 18.9 18.6 18.2
NT NT 19.0 NT 19.3 18.4
18.2 NT
18.4 18.3 18.4
NT 17.7 17.7 18.3 18.7
18.7 19.0 18.8 17.1 18.6 18.2 18.1 18.2 19.3 18.0
32.5 30.9 32.1 32.0
NT NT 31.5 NT 32.0 31.7
31.1 NT
32.3 31.4 32.4
NT 30.7 31.0 31.5 31.8
30.4 32.3 32.0 31.3 31.1 31.0 31.8 31.5 32.2 32.0
RDW ARET PLT WBC
% xlO"^/flL x I O ^ / m L x 10^3/^L
11.3 11.6 12.1 11.2
NT NT 11.0 NT 11.0 11.1
11.9 NT
10.9 10.9 11.2
NT 13.0 11.5 10.3 11.8
11.2 11.0 11.9 11.5 11.6 11.5 11.2 11.6 12.0 11.8
185. 178. 205. 184.
NT NT 199. NT 187. 165.
213. NT
155. 210. 187.
NT 251. 211. 165. 120.
171. 186. 233. 209. 214. 203. 164. 183. 274. 147.
1146 1081 1216 1254
NT NT 1218 NT 1086 1210
14.42 16.67 21.48 14.25
NT NT 18.51 NT 10.91 14.79
1304 NT
1081 1091 1258
NT KNV 1374 KNV 995
21.01 NT
14.26 9.46
19.93 NT
15.36 13.62 14.11 12.59
RNV 1211 1205 1062 1018
947 1155 1182 1237 1082
18.64 17.76 12.39 17.95 15.29 21.26 18.22 14.33 15.01 12.84
637
Company Sanitized. Does not contain TSCA CBi
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____
)
DuPont-6554
Animal Number
COND
RBC
xlOrt6/h
HGB g/dL
Male, Group: VII - 60 mg/kg - Day 38
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
OK 8.24 15.4 OK 8.03 14.6 OK 8.08 15.4 OK 8.14 15.0 OK 7.94 14.6 OK 8.02 14.3 OK 7.88 14.9 OK 7.93 14.7 OK 7.60 14.0 OK 7.84 14.8
Male, Group: IX - 300 mg/kg - Day 38
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
OK CLOT
OK OK OK OK OK OK OK OK
6.82 NT
8.06 7.94 7.72 7.43 7.95 8.49 7.85 7.49
13.1 NT
14.3 14.4 14.4 13.4 14.1 15.2 14.3 14.5
Individual Hematology Values
HCT MCV MCH MCHC % L p g g/dL
48.1 46.0 47.2 47.1 47.1 45.7 46.5 46.4 44.9 46.6
42.1 NT
45.1 46.4 44.7 42.4 44.3 48.0 44.0 45.1
58.4 57.3 58.4 57.9 59.3 56.9 58.9 58.5 59.1 59.4
61.7 NT
55.9 58.4 57.9 57.0 55.8 56.6 56.1 60.2
18.7 18.2 19.1 18.4 18.4 17.8 18.9 18.5 18.4 18.8
19.2 NT
17.7 18.2 18.6 18.0 17.8 18.0 18.2 19.4
32.0 31.8 32.6 31.8 31.0 31.3 32.0 31.7 31.2 31.7
31.2 NT
31.7 31.2 32.1 31.6 31.9 31.7 32.5 32.2
RDW ARET PLT WBC % x 10^3/m L xlO^/aL xlO^/fiL
11.8 11.4 10.7 11.0 11.3 11.0 11.7 11.6 13.0 11.1
11.2 NT
12.6 11.6 11.9 11.5 10.8 12.0 11.9 11.3
192. 180. 170. 164. 180. 171. 223. 141. 244. 157.
207. NT
227. 142. 202. 196. 178. 222. 174. 212.
1282 1092 1280 1283 1132 1100 1324 1136 1347 1116
16.17 9.45
14.60 18.89 11.16 14.38 17.51 14.15 13.69 12.39
1310 NT
1485 1261
RNV 1402 1307 1351
RNV 1078
16.75 NT
16.38 19.50 16.31 18.79 16.72 15.29 15.61 17.46
638
Semspffljy Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal
ANEU
ANPR
Number x I O ^ / m L xlOA3//iL
Individual Hematology Values
ALYM
AMON
x 1 0 ,'3/m L x I O ^ / m L
AEOS KlO^Z/iih
ABAS
ALUC
x I O ^ / m L x 10"3/m L
ABLT
x I O ^ / mL
AMSC
x !0"3/m L
Male, Group: I - 0 mg/kg - Day 38
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
1.20 1.68 1.57 1.12
NT NT 1.16 NT 1.43 1.80
NT 12.36 NT 14.15 NT 18.99 NT 12.36 NT NT NT NT NT 16.45 NT NT NT 8.59 NT 12.32
Male, Group: III - 60 mg/kg - Day 38
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
2.31 NT
2.03 1.22 1.77
NT 2.00 1.04 1.06 1.80
NT NT NT NT NT NT 0 .00 NT NT NT
17.54 NT
11.43 7.82
17.20 NT
12.60 11.62 12.29 10.10
Male, Group: V - 10 mg/kg - Day 38
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
1.32 1.94 1.42 2.30 1.44 3.57 1.19 1.67 1.50 1.71
NT 16.11 NT 14.96 NT 10.35 NT 14.70 NT 13.05 NT 16.28 NT 15.97 NT 11.80 NT 12.63 NT 10.20
0.42 0.49 0.59 0.42
NT NT 0.50 NT 0.60 0.30
0.66 NT
0.47 0.30 0.59
NT 0.77 0.68 0.45 0.29
0.81 0.46 0.33 0.61 0.38 0.54 0.60 0.54 0.53 0.61
0.28 0.13 0.10 0.13
NT NT 0.11 NT 0.13 0.16
0.23 NT
0.16 0.06 0.16
NT 0.00 0.14 0.09 0.21
0.17 0.13 0.15 0.18 0.09 0.53 0.18 0.12 0.13 0.13
0.09 0.11 0.10 0.14
NT NT 0.19 NT 0.12 0.12
0.09 NT
0.11 0.05 0.11
NT 0.00 0.05 0.14 0.09
0.11 0.19 0.09 0.09 0.22 0.18 0.14 0.11 0.09 0.12
0.08 0.10 0.12 0.10
NT NT 0.11 NT 0.05 0.08
0.18 NT
0.06 0.03 0.09
NT 0.00 0.08 0.07 0.11
0.12 0.08 0.05 0.07 0.11 0.16 0.14 0.09 0.13 0.07
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT 0-00 NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT 0.00 NT NT NT
NT NT NT NT NT NT NT NT NT NT
SPEC
639
ComPany Sw itized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
ANEU
x 10a 3/m L
ANPR xl0A3//iL
Individual Hematology Values
ALYM
AMON
xl0A3/a, x 1 0 a 3 / m L
AEOS
ABAS
xlOA3//iL x 1 0 a 3 / m L
ADUC
x 10a 3/m B
ABLT xl0A3//iL
AMSC xlOA3/iiL
Male, Group:: VII - 60 mg/kg - Day 38
648223
2.20
NT 12.89
0.53
0.29
0.13
0.14
NT
NT
648237
2.12
NT 6.75 0.37 0.12 0.05 0.05
NT
NT
648243
1.49
NT 12.23
0.57
0.17
0.07
0.08
NT
NT
648244
2.45
NT 15.27
0.79
0.18
0.09
0.10
NT
NT
648259
1.48
NT 9.08 0.31 0.17 0.06 0.06
NT
NT
648266
1.92
NT 11.54
0.64
0.11
0.10
0.07
NT
NT
648270
1.78
NT 14.45
0.75
0.34
0.09
0.11
NT
NT
648280
1.79
NT 11.76
0.30
0.20
0.07
0.04
NT
NT
648300
1.29
NT 11.27
0.40
0.09
0.20
0.42
NT
NT
648305
1.25
NT 10.47
0.33
0.18
0.05
0.13
NT
NT
Male, Group:: IX - 300 mg/kg - Day 38
648217
2.02
NT 13.57
0.74
0.25
0.06
0.10
NT
NT
648218 NT NT NT NT NT NT NT NT NT
648235
1.87
NT 13.33
0.85
0.14
0.09
0.12
NT
NT
648236
1.91
NT 16.63
0.33
0.29
0.21
0.13
NT
NT
648239
2.96
NT 12.12
0.89
0.16
0.09
0.09
NT
NT
648248
1.43
NT 16.63
0.32
0.15
0.16
0.10
NT
NT
648275
1.55
NT 14.09
0.68
0.21
0.11
0.07
NT
NT
648289
2.07
NT 12.60
0.44
0.07
0.06
0.05
NT
NT
648293
1.68
NT 12.52
0.73
0.52
0.07
0.10
NT
NT
648308
2.25
NT 14.16
0.66
0.18
0.11
0.10
NT
NT
SPEC
640
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______________________________
)
)
DuPont-6554
Animal Number
COND
RBC
xlO ''6/mL
HGB g/dL
Male, Group: I - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
OK 7.97 15.0 OK 8.37 15.2 OK 8.58 15.3 OK 8.79 15.2 OK 7.73 14.2 OK 8.80 15.6 OK 8.26 15.2 NSR NT NT OK 8.36 15.3 OK 8.81 15.5
Male, Group: III - 60 mg/kg - Day 92
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
OK 8.92 15.7 OK 6.92 12.6 OK 8.59 15.3 OK 8.23 14.9 OK 8.15 14.6 OK 9.54 16.5 OK 8.28 14.1 OK 8.94 15.3 OK 8.93 15.6 OK 8.61 15.6
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
OK 8.25 14.2 OK 8.28 15.2 OK 8.27 15.1 OK 9.02 14.9 OK 7.60 13.8 OK 8.36 14.8 OK 8.54 14.7 OK 8.42 14.6 OK 7.56 13.6 OK 8.56 14.3
Individual Hematology Values
HCT MCV MCH MCHC % fL pg g/dL
46.6 47.5 48.2 48.1 43.1 49.6 47.2
NT 47.1 48.8
48.3 41.1 48.0 46.7 45.5 51.8 44.5 47.9 47.5 49.7
45.6 47.7 47.0 47.8 42.2 45.3 46.8 45.4 43.3 45.6
58.5 56.8 56.2 54.8 55.7 56.4 57.1
NT 56.4 55.4
54.1 59.4 55.9 56.7 55.9 54.3 53.7 53.6 53.2 57.7
55.3 57.6 56.9 53.0 55.5 54.3 54.7 53.9 57.3 53.3
18.8 18.2 17.8 17.3 18.3 17.8 18.5
NT 18.4 17.6
17.6 18.2 17.8 18.1 17.9 17.3 17.1 17.2 17.5 18.1
17.3 18.4 18.3 16.5 18.2 17.7 17.2 17.4 17.9 16.7
32.2 32.1 31.7 31.6 32.9 31.5 32.3
NT 32.6 31.9
32.5 30.7 31.8 31.9 32.1 31.9 31.8 32.0 32.9 31.4
31.2 31.9 32.1 31.1 32.8 32.6 31.5 32.2 31.3 31.3
RDW ARET PLT WBC % x I O ^ / m L x I O ^ / m L xlO
13.5 12.2 13.3 12.5 14.9 13.3 12.4
NT 12.5 12.8
12.7 14.3 12.5 12.1 13.7 12.6 15.8 12.3 11.4 12.2
13.5 12.8 12.5 12.3 13.1 12.2 12.8 12.6 13.3 13.5
237. 182. 170. 180. 212. 179. 184.
NT 195. 165.
188. 268. 145. 239. 231. 157. 210. 179. 188. 130.
180. 173. 164. 144. 192. 187. 158. 178. 267. 154.
1189 1187 1077 1278 1141 1138 1186
NT 1094 1104
14.87 14.50 14.13
9.51 17.00 10.77 13.81
NT 9.14 11.11
1284 1092 1161
989 1136 1060
RNV 1253 1188
823
15.29 18.01 15.31
8.50 17.41 13.30 12.70 11.40 12.03
7.18
1352 1142 1106 1038
915 1158
987 1108 1084 1033
14.18 18.06 11.72 14.84
9.87 13.80 12.88 11.20 11.57 10.85
641
Company Sanitized. Does not contain TSCA CBI
>
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____________________
)
DuPont-6554
Animal Number
COND
RBC
xlO^/fiL
HGB g/dL
Male, Group : VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
OK 8.48 14.8 OK 8.46 14.4 OK 7.90 14.4 OK 8.22 14.6 OK 8.47 14.9 OK 8.56 14.3 OK 7.73 13.9 OK 8.33 14.5 OK 7.68 13.7 OK 7.93 14.2
Male, Group: IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
OK 7.04 13.3 OK 7.49 13.3 OK 8.09 13.6 OK 7.94 13.6 OK 7.91 13.6 OK 7.75 13.3 OK 8.18 13.8 OK 8.69 14.4 OK 7.96 13.8 OK 7.97 14.8
Individual Hematology Values
HOT MCV MCH MCHC
%
fL '
pg
g/dL
47.1 44.5 44.1 45.5 46.4 45.8 43-7 45.3 42.6 44.7
40.3 41.5 43.7 41.8 43.3 40.9 43.9 45.9 42.6 46.0
55.6 52.6 55.9 55.4 54.8 53.6 56.6 54.3 55.6 56.4
57.2 55.3 54.0 52.7 54.8 52.8 53.7 52.8 53.4 57.7
17.4 17.1 18.3 17.8 17.6 16.7 18.1 17.4 17.8 18.0
18.9 17.7 16.8 17.1 17.2 17.2 16.9 16.6 17.4 18.5
31.3 32.5 32.7 32.1 32.0 31.3 31.9 32.0 32.1 31.8
33.1 32.0 31.1 32.5 31.4 32.5 31.4 31.4 32.5 32.1
RDW ARET PLT WBC % x I O ^ / m L x 10~3/m L xlOA3//*L
13.4 13.0 11.8 11.8 11.6 12.6 12.2 13.9 13.1 11.8
14.1 12.7 14.6 14.2 13.7 12.8 12.8 13.0 14.5 12.4
186. 185. 167. 162. 143. 178. 165. 154. 167. 180.
196. 198. 208. 156. 207. 162. 165. 127. 157. 176.
1043 974
1284 1302 1213 1171 1275 1214 1232 1150
10.96 8.01
14.68 15.18 10.00 15.22 13.86 13.91 11.50
8.93
1079 1476 1326
RNV 1245 1396 1211 1207 1176 1060
17.10 13.87 13.98 15.87 12.40 12.99 13.22 12.97 12.01 13.30
642
Company Sanitized. Does not contain TSCA CSt
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________
)
Animal Number
ANEU
ANPR
xlO'^3/it, xlO ~3/ML
Individual Hematology Val
ALYM
AMON
AEOS
ABAS
x!0A3/fiL x !0^3/m L xl0^3/(J.L x I O ^ / m L
Male, Group:: I - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
1.67 2.61 1.70 1.08 1.57 1.86 1.09
NT 1.32 1.73
NT 12.31 NT 11.18 NT 11.91 NT 8.05 NT 14.64 NT 8.31 NT 11.84 NT NT NT 7.24 NT 8.83
Male, Group:: III - 60 mg/kg - Day 92
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
2.64 5.84 2.32 1.44 2.39 1.58 2.14 1.04 1.50 0.86
NT 11.76 NT 10.90 NT 11.98 NT 6.56 NT 14.01 NT 10.85 NT 9.47 NT 9.79 NT 9.84 NT 5.93
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
4.14 2.40 2.85 1.77 1.40 3.71 1.32 1.23 1.84 3.04
NT NT NT NT NT NT NT NT NT 0.00
9.21 14.82
8.33 12.33
7.90 9.45 10.94 9.45 9.16 7.70
0.34 0.20 0.24 0.12 0.36 0.20 0.21
NT 0.25 0.19
0.29 0.74 0.42 0.29 0.46 0.17 0.64 0.22 0.26 0.17
0.48 0.37 0.23 0.35 0.20 0.24 0.19 0.17 0.29 0.11
0.27 0.10 0.07 0.08 0.11 0.11 0.23
NT 0.13 0.17
0.19 0.09 0.22 0.08 0.13 0.24 0.15 0.08 0.10 0.10
0.09 0.11 0.10 0.14 0.11 0.14 0.24 0.09 0.12 0.00
0.11 0.27 0.06 0.12 0.14 0.22 0.24
NT 0.12 0.12
0.22 0.08 0.19 0.04 0.22 0.29 0.14 0.18 0.20 0.06
0.09 0.11 0.08 0.12 0.14 0.16 0.06 0.20 0.07 0.00
643
DuPont-6554
ues
ALUC
x I O ^ / mL
ABLT
x 10-'3/m L
AMSC
x!0A3/nh
SPEC
0.18 0.13 0.15 0.07 0.18 0.07 0.21
NT 0.07 0.07
0.19 0.37 0.18 0.08 0.20 0.17 0.17 0.08 0.13 0.06
0.17 0.24 0.12 0.13 0.12 0.10 0.13 0.06 0.09 0.00
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT 0.00
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT 0.00
Company Sanitized. Do<08 nof contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
))
_________________________D u P o n t-6 5 5 4
Animal
ANEU
ANPR
Number x 1 0 a 3 / m L x I O ''3/m L
Individual Hematology Values
ALYM
AMON
AEOS
ABAS
ALUC
ABLT
AMSC
xl0A3/iiL xlO^J/h x 1 0 a 3 / m L x 1 0 a 3 / m L x 1 0 a 3 / m L xlO^l/L xl0A3//iL
Male, Group: VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
2..14 2..01 3 .02 3 .01 2..15 3..63 1..71 2,.38 1 .28 0 .97
NT 8..20 NT 5..47 NT 11..09 NT 11..42 NT 7..33 NT 10..60 NT 11..60 NT 10..71 NT 9 .62 NT 7..54
Male, Group : IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
2..91 1..87 2..74 2..61 2..64 1..91 1..62 1,.93 1..18 2..26
0 .17 NT NT NT NT NT NT NT NT NT
13..68 11..38 10..25 12..38
9..16 10..42 10..96 10..30 10..16 10..25
0,.38 0..29 0 .22 0 .37 0..27 0 .50 0..24 0..31 0 .19 0 .15
0,.34 0 .26 0..45 0..22 0..29 0..22 0..32 0..42 0,.31 0.,42
0,.13 0..11 0 .18 0..22 0..14 0..23 0..11 0,.24 0 .10 0 .10
0,.00 0,.14 0..35 0..40 0..06 0..20 0..18 0..08 0..16 0..08
0..06 0..03 0..08 0..05 0..05 0..15 0..07 0.,10 0..14 0..11
0.,00 0,.11 0..11 0.,14 0..11 0..09 0..06 0,.11 0..08 0..09
0..05 0..09 0..08 0..10 0..05 0..11 0..12 0..18 0..15 0,.06
0..00 0..12 0..08 0.,12 0..14 0..15 0..08 0..13 0..13 0..20
NT NT NT NT NT NT NT NT NT NT
0.00 NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
0.00 NT NT NT NT NT NT NT NT NT
SPEC 1%-BAND
644
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_________
}
)
DuPont-6554
Animal Number
COND
RBC
xlO ''6/aL
HGB g/dL
Male, Group: X - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
OK 9.07 15.7 OK 9.26 16.5 OK 9.46 16.0 OK 8.69 15.6 OK 8.88 14.8 OK 9.00 15.8 OK 8.52 15.2 OK 8.56 14.3 OK 9.21 15.7 OK 8.79 15.2
Male, Group: XX - 300 mg/kg - Day 122
648216 648230 648241 648249 648261 648262 648282 648284 648306
OK OK OK OK OK OK OK OK CLOT
8.94 8.26 8.27 8.23 8.06 7.64 7.47 7.82
NT
16.0 14.5 14.1 14.5 14.7 14.3 13.4 14.5
NT
Individual Hematology Values
HCT MCV MCH MCHC % fL pg g/dL
48.3 50.3 49.2 47.0 47.7 47.7 45.7 44.9 48.5 46.6
48.2 44.5 43.3 45.8 44.7 44.4 41.7 43.4
NT
53.3 54.3 52.0 54.1 53.7 53.0 53.6 52.4 52.7 53.0
53.9 53.9 52.3 55.6 55.4 58.1 55.8 55.5
NT
17.3 17.8 16.9 18.0 16.7 17.6 17.8 16.7 17.0 17.3
17.9 17.6 17.0 17.6 18.2 18.7 17.9 18.5
NT
32.5 32.8 32.5 33.2 31.0 33.1 33.3 31.9 32.3 32.6
33.2 32.6 32.6 31.7 32.9 32.2 32.1 33.4
NT
RDW %
ARET xlO^/fiL
PLT
x 10a 3/m L
WBC x 10a3/m L
13.3 12.1 12.8 13.4 14.0 13.5 13.9 14.7 14.4 13.2
13.3 13.1 13.0 14.3 13.7 13.1 13.5 13.2
NT
230. 136. 185. 196. 191. 163. 178. 209. 189. 149.
188. 172. 166. 237. 162. 213. 180. 198.
NT
1111 1065 1207
769 908 1164 972 1022 1100 1158
13.13 9.84
10.18 9.87
13.41 6.53 9.93
10.72 15.90
8.00
877 1237
981 1170 1259 1125
971 1189
NT
7.11 11.56 12.60 10.77 14.27
9.84 9.78 16.03
NT
645
Company Sanitized. Does not contain TSCA CBS
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
ANEU xlO-'3/#iL
Individual Hematology Values
ALYM
AMON
AEOS
ABAS
ALUC
ABLT
xlOin3/iih xl0A3/fiL x l O ^ / M b x 10~3/m L x I O ^ / m L xlO
Male, Group: I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
2.69 1.68 2.13 2.36 2.62 1.39 1.58 2.17 2.05 2.10
9.66 7.59 7.58 6.95 9.90 4.83 7.71 7.85 13.05 5.42
0.26 0.31 0.17 0.27 0.47 0.12 0.33 0.38 0.45 0.24
Male, Group: IX - 300 mg/kg - Day 122
648216 648230 648241 648249 648261 648262 648282 648284 648306
1.32 2.38 2.78 1.96 2.18 1.36 2.14 2.79
NT
5.44 8.58 9.21 8.23 11.44 8.12 6.99 12.38
NT
0.20 0.29 0.34 0.27 0.27 0.16 0.39 0.35
NT
0.18 0.15 0.07 0.15 0.08 0.08 0.17 0.14 0.13 0.12
0.07 0.19 0.08 0.13 0.10 0.06 0.08 0.24
NT
0.25 0.05 0.17 0.06 0.20 0.05 0.06 0.11 0.10 0.05
0.04 0.06 0.09 0.10 0.17 0.08 0.05 0.14
NT
0.08 0.05 0.06 0.08 0.13 0.07 0.08 0.09 0.14 0.06
0.04 0.07 0.10 0.09 0.11 0.07 0.12 0.13
NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT
) DuPont-6554
646
Company Sanitized. Does not contain TSCA OBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
COND
RBC
xlO''S/iiL
HGB g/dL
Male, Group: I ~ 0 mg/kg - Day 183
648219 648226 648228 648297 648298
OK OK OK CLOT OK
8.85 8.42 9.08
NT 9.13
15.7 15.3 16.0
NT 15.4
Male, Group: V - 10 mg/kg -- Day 183
648253 648254 648265 648283 648310
OK 8.27 14.3 OK 8.96 15.4 OK 8.86 15.6 OK 8.41 14.9 OK 8.53 15.5
Male, Group: VII - 60 mg/kg - Day 183
648268 648279 648285 648296 648314
OK 7.81 14.0 OK 8.85 15.5 OK 8.59 14.5 OK 8.63 15.3 OK 7.83 14.0
Male, Group: IX - 300 mg/kg - Day 183
648234 648240 648272 648287 648292
CLOT OK OK OK OK
NT 8.88 8.69 8.38 8.62
NT 14.8 14.2 13.6 15.1
Individual Hematology Values
HCT MCV MCH MCHC
%
fL -
pg
g/dL
47.9 47.2 49.4
NT 49.1
45.2 48.1 48.4 .48.2 47.9
43.7 48.1 46.1 46.9 42.9
NT 45.7 44.7 43.5 46.6
54.1 56.0 54.4
NT 53.8
54.6 53.7 54.6 57.3 56.2
56.0 54.3 53.7 54.4 54.8
NT 51.5 51.4 51.9 54.1
17.7 18.2 17.6
NT 16.9
17.3 17.2 17.6 17.7 18.2
17.9 17.5 16.9 17.7 17.9
NT 16.7 16.3 16.2 17.5
32.8 32.4 32.4
NT 31.4
31.7 32.0 32.2 30.9 32.3
32.0 32.3 31.4 32.6 32.6
NT 32.4 31.8 31.3 32.4
RDW %
ARET
x 1 0 a 3//L
PLT X1CT3/ML
WBC
x 10~3/m L
12.4 12.8 12.2
NT 14.0
13.3 12.7 13.8 14.1 13.5
15.4 13.8 13.2 13.8 12.7
NT 13.4 14.0 14.4 13.8
159. 121. 115.
NT 228.
895 1196
912 NT
RNV
8.06 9.92 13.88
NT 14.65
181. 176. 207. 173 . 192.
1393 1142 1091 1012
787
13.74 itf.59 13.54 10.62
8.29
229. 179. 170. 189. 240.
998 966 RNV 891 1188
10.65 13.06
7.99 11.59 15.46
NT 139. 198. 225. 209.
NT 888 RNV 1098 813
NT 13.16
9.45 13.85
8.52
647
ComPany Sanitized. Doe;
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
ANEU xlO A3/aL
ALYM xl0A3/#lL
AMON
xlO n3/h
Individual Hematology Values
AEOS
ABAS
ALUC
ABLT
xlO*3/L x 10a 3/m L xlOA3// xlOA3//iL
Male, Group:: I - 0 mg/kg -- Day 183
648219 648226 648228 648297 648298
1.29 1.58 2.28
NT 1.35
6.42 7.88 10.59
NT 12.77
0.13 0.23 0.51
NT 0.29
Male, Group:; V - 10 mg/kg - Day 183
648253 648254 648265 648283 648310
2.32 0.68 3.55 1.00 1.40
10.91 9.46 9.37 9.03 6.42
0.22 0.13 0.18 0.33 0.19
Male, Group: VII - 60 mg/kg - Day 183
648268 648279 648285 648296 648314
2.22 1.91 1.17 2.63 4.24
7.75 10.47
6.49 8.34 10.22
0.44 0.21 0.15 0.32 0.45
Male, Group: IX - 300 mg/kg - Day 183
648234 648240 648272 648287 648292
NT 1.87 3.80 1.91 1.35
NT 10.80
5.07 11.16
6.66
NT 0.22 0.40 0.46 0.25
0.07 0.14 0.21
NT 0.09
0.16 0.17 0.26 0.12 0.08
0.09 0.26 0.06 0.09 0.42
NT 0.11 0.09 0.08 0.10
0.10 0.07 0.14
NT 0.04
0.04 0.07 0.07 0.04 0.12
0.07 0.12 0.06 0.10 0.09
NT 0.09 0.02 0.10 0.08
0.06 0.04 0.14
NT 0.09
0.07 0.07 0.11 0.12 0.07
0.10 0.09 0.06 0.09 0.06
NT 0.07 0.08 0.12 0.08
NT NT NT NT NT
NT NT NT NT NT
NT NT NT NT NT
NT NT NT NT NT
SPEC
DuPont-6554
648
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
COND
RBC
xlO''6/L
HGB g/dL
Female, Group: II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
OK 7.82 14.8 OK 8.50 15.1 OK 8.45 15.9 OK 7.86 14.5 OK 8.53 15.6 OK 8.21 15.2 OK 8.26 15.6 OK 8.57 16.2 OK 8.14 15.4 OK 8.58 16.0
Female, Group : IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
OK 7.55 14.4 OK 8.16 14.9 OK 8.23 15.2 OK 8.47 15.6 OK 8.27 15.0 OK 8.57 15.5 OK 8.52 15.9 OK 8.10 15.6 OK 8.20 15.6 OK 8.19 15.1
Female, Group: VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
OK OK OK OK OK CLOT OK OK OK OK
8.07 7.91 7.68 7.89 8.72
NT 8.53 8.24 7.82 8.04
15.0 14.6 14.8 14.7 15.4
NT 15.6 15.4 14.4 14.9
Individual Hematology Values
HCT MCV MCH MCHC % L pg g/dL
45.0 47.9 50.7 44.5 48.1 47.1 48.9 51.7 47.4 50.0
43.8 47.0 46.9 48.8 46.5 48.2 48.8 48.5 47.7 47.2
47.4 45.7 45.5 47.1 48.9
NT 48.7 47.7 45.3 46.5
57.5 56.4 60.0 56.6 56.4 57.4 59.2 60.3 58.2 58.3
58.0 57.6 57.0 57.7 56.2 56.2 57.4 59.8 58.2 57.6
58.8 57.7 59.2 59.7 56.1
NT 57.1 57.9 58.0 57.9
18.9 17.8 18.8 18.4 18.3 18.5 18.9 18.9 18.9 18.7
19.1 18.3 18.5 18.4 18.1 18.1 18.6 19.3 19.0 18.5
18.7 18.4 19.2 18.6 17.7
NT 18.3 18.6 18.4 18.6
32.8 31.5 31.3 32.6 32.4 32.3 31.9 31.4 32.5 32.0
32.9 31.8 32.4 31.9 32.2 32.3 32.5 32.2 32.7 32.1
31.7 31.9 32.5 31.1 31.6
NT 32.1 32.2 31.8 32.1
ROW ARET PLT WBC % x 1CT3/m L X1CT3/ML x 10~3/m L
11.3 11.8 10.5 11.8 11.4 11.0 11.1 10.5 10.5 10.9
10.9 10.9 10.3 11.4 11.2 10.7 11.1 10.6 11.3 11.0
11.3 11.0 11.3 10.8 11.3
NT 11.0 11.3 11.2 11.6
158. 172. 259. 185. 155. 154. 208. 237. 216. 178.
196. 167. 190. 188. 173. 186. 181. 165. 200. 235.
186. 164. 199. 200. 142.
NT 178. 210. 186. 178.
RNV 1178 1018 1176 1069 1108
RNV 966 1178 1283
14.89 11.67
9.15 10.08 13.07 13.66
9.95 7.16 6.84 11.52
1049 1242 1000 1168
968 1143
RNV 1266 1115 1456
11.43 16.42
9.48 10.90 10.61 11.80 10.79
16.19 12.33
8.46
786 1340 1209 1258
965 NT
1176 1173 1209 1095
7.69 12.18 11.59 12.14 10.98
NT 12.98
8.94 12.68 10.51
649
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
DuPont-6554
Animal Number
COND
RBC
xlOA6/yL
HGB g/dL
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
OK 7.73 15.2 OK 8.69 15.8 OK 7.60 13.7 OK 7.84 14.7 OK 8.06 15.3 OK 7.80 15.0 OK 7.83 14.5 OK 8.18 15.5 OK 7.93 14.9 OK 7.85 14.9
Female, Group: X - 300 mg/kg - Day 39
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
OK 7.07 14.1 OK 8.61 15.7 OK 7.53 15.1 OK 8.64 16.4 OK 8.07 15.0 OK 8.05 14.7 OK 8.03 15.2 OK 9.21 16.8 OK 8.01 15.1 OK 7.70 14.3
Individual Hematology Values
HCT MCV MCH MCHC % fL per g/dL
46.6 50.4 43.2 45.8 48.1 46.3 44.4 48.2 45.7 45.9
43.0 49.0 44.9 50.5 46.9 45.4 46.3 52.8 46.9 44.8
60.3 58.1 56.8 58.5 59.6 59.4 56.7 59.0 57.7 58.5
60.8 56.9 59.7 58.5 58.0 56.4 57.7 57.3 58.6 58.2
19.6 18.2 18.0 18.8 18.9 19.3 18.5 19.0 18.8 19.0
19.9 18.3 20.1 19.0 18.6 18.3 18.9 18.2 18.8 18.6
32.6 31.4 31.7 32.2 31.8 32.4 32.7 32.2 32.5 32.5
32.8 32.2 33.7 32.5 32.1 32.4 32.7 31.8 32.2 32.0
RDW ARET PLT WBC % x!0A3/iiL xlOA3/iL xlO^/fiL
11.1 10.9 10.6 10.9 11.1 11.6 11.2 11.7 11.1 11.3
11.2 11.0 10.5 10.7 11.4 10.9 10.5 10.8 11.1 11.4
212. 181. 157. 168. 181. 159. 174. 225. 235. 241.
229. 170. 193. 207. 226. 161. 170. 174. 229. 218.
RNV RNV 1104 1030 1386 1308 1124 1001 1147 1062
11.77 15.34 11.05 13.41 20.30
7.76 9.06 8.98 10.27 18.66
1025 1023
972 RNV RNV 944 1215 750 1162 1151
9.89 14.41 11.76 12.87 15.32 10.22 11.91 15.32 14.03 14.27
Sampanf Sanitized. Does not contain TSCA CBF
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
ANEU xIO^/mL
ANPR x 10^3/m L
Individual Hematology Val
ALYM
AMON
AEOS
ABAS
x!0A3//iL xlO~3//L x 10a 3/Ij xlO~3/iiL
Female, Group: II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
0.45 1.21 0.67 0.82 0.77 1.37 0.79 0.74 0.30 0.85
0.00 NT NT NT NT NT NT NT NT NT
14.00 9.72 8.18 8.86
11.60 11.73
8.52 5.99 6.32 10.20
Female, Group: IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
1.01 2.53 1.10 1.09 1.13 1.53 1.85 1.98 0.98 0.85
NT 9.61 NT 13.16 NT 8.00 NT 9.17 NT 8.96 NT 9.74 NT 8.34 NT 13.43 NT 10.58 NT 7.06
Female, Group: VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
0.94 1.02 1.88 0.71 0.77
NT 1.79 1.82 1.35 0.63
NT 6.22 NT 10.38 NT 9.10 NT 10.99 NT 9.72 NT NT NT 9.49 NT 6.74 NT 10.44 NT 9.04
0.44 0.29 0.17 0.21 0.20 0.24 0.20 0.19 0.11 0.16
0.32 0.38 0.15 0.29 0.24 0.23 0.26 0.34 0.39 0.29
0.17 0.46 0.30 0.24 0.17
NT 1.23 0.11 0.44 0.42
0.00 0.17 0.06 0.07 0.13 0.09 0.34 0.07 0.04 0.18
0.08 0.14 0.13 0.13 0.09 0.12 0.22 0.17 0.14 0.09
0.09 0.11 0.10 0.03 0.17
NT 0.11 0.17 0.09 0.17
0.00 0.18 0.03 0.05 0.15 0.08 0.03 0.07 0.04 0.04
0.22 0.09 0.04 0.06 0.07 0.05 0.07 0.08 0.11 0.06
0.15 0.08 0.09 0.07 0.06
NT 0.12 0.04 0.17 0.13
651
DuPont-6554
ues
ALUC
ABLT
AMSC
x I O ^ / m L xio ^3/lih xlO^/jiH
SPEC
0.00 0.10 0.03 0.06 0.21 0.15 0.07 0.11 0.04 0.08
0.19 0.13 0.05 0.16 0.12 0.12 0.05 0.18 0.12 0.11
0..11 0..13 0..12 0..09 0..10
NT 0..24 0..05 0,.19 0..13
0.00 NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
0.00 NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT NT
Company Sanitized. Does
icACSF
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
ANEU x 10/'3/m L
ANPR xlO-'3//iL
ALYM xlO^/Mb
Individual Hematology Values
AMON
AEOS
ABAS
ALUC
x IO^/mL xlO^/ML x IO^/mL xIO^/mL
ABLT x 10~3/m L
AMSC x 10~3/m L
Female, Group: VIII - 60 mg/kg - Day 39
648348
1.37
NT 9.67 0.30 0.25 0.10 0.09
NT
NT
648354
1.13
NT 13.61
0.20
0.19
0.06
0.14
NT
NT
648362
1.43
NT 9.02 0.14 0.31 0.04 0.11
NT
NT
648368
2.18
NT 10.70
0.20
0.10
0.10
0.12
NT
NT
648380
1.63
NT 17.90
0.27
0.17
0.17
0.15
NT
NT
648381
0.69
NT 6.45 0.31 0.13 0.09 0.10
NT
NT
648401
0.74
NT 7.78 0.25 0.12 0.09 0.07
NT
NT
648417
0.82
NT 7.41 0.48 0.10 0.07 0.09
NT
NT
648432
1.19
NT 8.44 0.22 0.11 0.17 0.14
NT
NT
648440
2.35
NT 15.39
0.38
0.21
0.14
0.19
NT
NT
Female, Group: X - 300 mg/kg - Day 39
648347
1.66
NT 7.72 0.32 0.09 0.03 0.07
NT
NT
648363
1.34
NT 12.34
0.30
0.19
0.11
0.13
NT
NT
648376
1.96
NT 9.10 0.37 0.09 0.09 0.15
NT
NT
648388
2.08
NT 9.76 0.39 0.52 0.05 0.06
NT
NT
648392
2.10
NT 12.43
0.32
0.17
0.12
0.17
NT
NT
648400
1.21
NT 8.61 0.15 0.09 0.06 0.10
NT
NT
648407
1.02
NT 10.13
0.37
0.10
0.19
0.11
NT
NT
648412
0.65
NT 13.82
0.25
0.13
0.21
0.26
NT
NT
648435
1.29
NT 12.02
0.28
0.28
0.06
0.10
NT
NT
648438
1.91
NT 11.70
0.22
0.13
0.13
0.17
NT
NT
) DuPont-6554
652
Company Sanitized. Does not
1 SCA Ctti
H-24678; Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
COND
RBC
xlO^/iiL
HGB g/dL
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
OK 7.91 14.8 OK 8.22 14.7 OK 8.17 15.6 OK 7.40 13.9 OK 8.81 16.0 OK 8.28 15.7 OK 8.62 16.0 OK 8.30 16.3 OK 7.81 14.7 OK 8.85 16.3
Female, Group: IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
OK 7.48 14.2 OK 8.21 14.8 OK 8.18 15.3 OK 8.07 14.5 OK 8.35 15.1 OK 9.29 16.7 OK 8.66 16.2 OK 7.94 15.1 OK 7.99 15.0 OK 7.85 14.7
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
OK 8.36 15.7 OK 8.00 14.6 OK 7.85 14.9 OK 7.92 14.8 OK 8.95 16.2 OK 8.34 15.6 OK 8.07 14.6 OK 8.23 15.3 OK 8.03 14.9 OK 7.62 14.7
Individual Hematology Val
HCT MCV MCH % L pg
45.6 45.3 47.9 43.0 48.5 46.3 49.1 49.6 43.7 50.2
42.9 45.8 46.3 45.3 46.4 51.7 50.7 45.5 45.6 44.2
48.1 44.7 45.2 45.1 50.1 48.0 45.3 46.6 45.8 43.8
57.6 55.1 58.7 58.1 55.0 55.9 56.9 59.8 55.9 56.7
57.4 55.8 56.6 56.2 55.5 55.6 58.5 57.2 57.1 56.3
57.5 55.9 57.6 57.0 56.0 57.6 56.2 56.6 57.0 57.5
18.8 17.9 19.1 18.8 18.1 19.0 18.5 19.7 18.8 18.4
19.0 18.0 18.7 18.0 18.0 17.9 18.7 19.0 18.8 18.8
18.7 18.3 19.0 18.7 18.1 18.7 18.1 18.6 18.6 19.3
653
)
DuPont-6554
ues
MCHC g/dL
ROW ARET PLT WBC
% xlO^/ML
x 10a3/m L
xlQ"3/L
32.6 32.5 32.5 32.4 33.0 33.9 32.5 32.9 33.6 32.4
33.1 32.2 33.0 32.1 32.5 32.2 32.0 33.2 32.9 33.3
32.6 32.7 33.0 32.8 32.2 32.6 32.3 32.8 32.6 33.5
11.7 12.0 10.6 12.2 11.8 11.3 11.5 11.1 10.4 11.2
11.9 11.0 10.9 11.3 11.1 10.7 10.9 11.0 11.8 11.0
11.1 11.8 11.2 10.7 11.3 11.4 10.8 11.4 11.0 11.8
164. 136. 210. 205. 140. 122. 159. 239. 146. 108.
156. 123. 137. 121. 117. 159. 147. 133. 162. 125.
103. 187. 125. 138. 139. 169. 134. 165. 134. 153.
1065 1068 1137 1013 1018 1165
RNV RNV 1186 1147
11.42 9.50 7.84 8.53
10.95 8.71 9.17 6.27 7.97 8.59
1063 1183 1041 1135 1069 1099
762 1026
RNV RNV
10.77 10.51
9.68 8.93 7.77 9.61 7.44 9.32 8.05 6.77
663 1234 1173 1197 1102 1022
988 RNV 1191 1017
7.59 7.26 8.76 12.79 12.19 6.40 9.78 11.57 8.85 8.04
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
COND
RBC
xl0*6/ilh
HGB g/dL
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
OK 7.51 15.1 OK 8.49 15.5 OK 8.22 14.8 OK 8.21 15.4 OK 7.97 14.7 OK 7.97 15.4 OK 8.17 15.4 OK 8.42 16.1 OK 7.73 14.4 OK 7.95 14.8
Female, Group: X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
OK 6.88 13.6 OK 8.84 15.9 OK 7.72 15.0 OK 8.05 15.4 OK 7.82 14.9 OK 8.30 15.4 OK 7.66 14.5 OK 7.59 13.8 OK 7.55 14.4 OK 7.97 14.9
Individual Hematology Values
HCT MCV MCH MCHC % fL pg g/dL
45.1 47.1 46.3 46.4 45.2 47.2 45.9 49.0 43.8 46.1
41.2 49.9 45.5 46.4 45.3 47.4 43.8 42.2 43.1 45.4
60.0 55.5 56.4 56.5 56.7 59.2 56.2 58.3 56.7 58.0
59.9 56.4 58.9 57.6 58.0 57.1 57.2 55.6 57.0 57.0
20.1 18.2 18.1 18.8 18.4 19.3 18.8 19.1 18.6 18.6
19.8 18.0 19.4 19.1 19.0 18.5 18.9 18.2 19.1 18.7
33.5 32.9 32.0 33.2 32.5 32.6 33.5 32.8 32.8 32.1
33.1 31.8 33.0 33.1 32.8 32.5 33.1 32.7 33.4 32.7
ROW ARET PLT WBC % x l O ^ / ^ L xlOA3/iiL x 10^3/m L
11.3 11.1 11.1 11.2 11.1 11.3 11.4 11.7 11.4 11.9
11.5 11.5 10.9 11.3 11.1 10.9 10.9 11.2 11.6 11.0
204. 128. 139. 151. 114. 134. 161. 161. 162. 250.
208. 152. 166. 203. 148. 162. 180. 236. 144. 168.
1057 1156 1120 1090 1230 1220 1070
974 RNV 999
9.20 10.74
8.97 9.19 15.19 5.77 7.22 6.61 8.49 9.97
969 879 RNV 902 1142 803 1023 934 RNV 1024
7.57 7.56 9.25 11.18 10.11 9.28 6.60 10.32 12.44 12.12
654
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats________
)
Animal Number
ANEU
x!0n3/L
ANPR xlO^/ML
ALYM x IO^/mL
Individual Hematology Values
AMON
AEOS
ABAS
ALUC
x 10a 3/L xl0^3/h X 1 C T 3 /h xl0A3//iL
ABLT xl0^3//L
AMSC
xl0A3/h
Female, Group: II - 0 mg/kg - Day :93
648351
2.27
NT 8.62 0.15 0.10 0.11 0.16
NT
NT
648353
1.43
NT 7.45 0.21 0.15 0.20 0.06
NT
NT
648370
0.64
NT 6.75 0.15 0.08 0.11 0.10
NT
NT
648372
1.23
NT 6.87 0.22 0.04 0.11 0.06
NT
NT
648393
1.55
NT 8.69 0.28 0.14 0.19 0.10
NT
NT
648395
0.71
NT 7.61 0.15 0.11 0.07 0.06
NT
NT
648421
0.91
NT 7.65 0.15 0.26 0.08 0.12
NT
NT
648423
0.85
NT 5.07 0.10 0.05 0.11 0.08
NT
NT
648430
1.05
NT 6.34 0.23 0.20 0.09 0.07
NT
NT
648436
1.51
NT 6.53 0.18 0.21 0.06 0.09
NT
NT
Female, Group: IV - 60 mg/kg - Day 93
648364
1.01
NT 9.08 0.28 0.12 0.12 0.15
NT
NT
648369
0.56
NT 9.23 0.17 0.11 0.07 0.36
NT
NT
648390
1.08
NT 8.08 0.17 0.17 0.10 0.07
NT
NT
648396
0.69
NT 7.66 0.17 0.15 0.19 0.07
NT
NT
648397
0.82
NT 6.41 0.23 0.16 0.09 0.07
NT
NT
648402
1.12
NT 8.03 0.19 0.08 0.10 0.08
NT
NT
648408
0.71
NT 6.28 0.18 0.14 0.07 0.06
NT
NT
648409
1.36
NT 7.35 0.21 0.17 0.10 0.13
NT
NT
648410
0.65
NT 6.91 0.12 0.10 0.16 0.11
NT
NT
648424
1.73
NT 4.68 0.17 0.08 0.05 0.06
NT
NT
Female, Group: VI - 10 mg/kg - Day 93
648345
1.38
NT 5.51 0.24 0.30 0.06 0.10
NT
NT
648366
0.70
NT 5.98 0.24 0.14 0.10 0.10
NT
NT
648374
0.68
NT 7.48 0.26 0.13 0.13 0.09
NT
NT
648382
1.22
NT 10.95
0.27
0.09
0.11
0.15
NT
NT
648403
0.78
NT 10.85
0.18
0.13
0.12
0.12
NT
NT
648406
0.67
NT 5.26 0.06 0.05 0.19 0.16
NT
NT
648414
1.07
NT 7.99 0.34 0.09 0.16 0.14
NT
NT
648429
2.03
NT 8.82 0.28 0.29 0.04 0.11
NT
NT
648433
0.71
NT 7.51 0.22 0.08 0.19 0.14
NT
NT
648441
1.15
NT 6.18 0.21 0.15 0.22 0.13
NT
NT
) DuPont-6554
655
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
ANEU xlO^/aL
ANPR
x IO^/rL
ALYM xl0A3/m L
Individual Hematology Values
AMON xlOA3/jiL
AEOS
ABAS
xlO ''3/h x I O ^ / m L
ALUC
x 10a 3/m L
ABLT
x 10a 3/m L
AMSC
x IO^/mL
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
1.32 1.38 0.59 1.91 0.76 1.05 0.58 1.03 1.59 1.77
NT 7.13 NT 8.75 NT 7.72 NT 6.79 NT 13.57 NT 4.30 NT 6.21 NT 4.97 NT 6.25 NT 7.50
Female, Group: X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
0.64 1.12 1.49 2.34 1.42 0.97 1.39 1.10 2.34 2.49
NT NT NT NT 0.00 NT 0.00 NT NT NT
6.50 6.09 7.22 8.00 8.59 7.82 5.15 8.57 9.43 9.07
0.17 0.23 0.16 0.15 0.17 0.11 0.16 0.24 0.29 0.16
0.16 0.13 0.21 0.35 0.10 0.16 0.00 0.14 0.32 0.24
0.14 0.16 0.13 0.13 0.24 0.11 0.11 0.11 0.14 0.20
0.07 0.12 0.11 0.19 0.00 0.13 0.07 0.23 0.12 0.13
0.12 0.08 0.21 0.11 0.28 0.13 0.09 0.10 0.16 0.20
0.07 0.05 0.15 0.12 0.00 0.12 0.00 0.15 0.10 0.10
0.33 0.14 0.16 0.11 0.17 0.08 0.06 0.16 0.06 0.14
0.14 0.06 0.07 0.18 0.00 0.09 0.00 0.13 0.14 0.09
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT 0.00 NT 0.00 NT NT NT
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT 0.00 NT 0.00 NT NT NT
SPEC
656
Company Sanitized. Does not contain TSCA CBI
') )
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________
DuPont-6554
Animal Number
COND
RBC
xlO^/iiL
HGB g/dL
Female, Group : II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
OK OK OK OK OK OK CLOT OK NSR OK
7.94 7.89 8.17 8.43 8.52 7.36
NT 8.11
NT 7.11
14.5 15.7 15.0 15.6 15.9 14.6
NT 15.4
NT 13.7
Female, Group: X - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
OK 8.02 14.4 OK 7.89 15.5 OK 8.12 15.7 OK 8.65 16.0 OK 7.96 15.3 OK 7.62 14.6 OK 7.95 14.7 OK 8.14 15.3 OK 7.76 14.9
Individual Hematology Values
HCT MCV MCH MCHC % L p g g/dL
43.7 44.9 46.2 46.7 48.9 43.8
NT 47.0
NT 41.2
44.9 47.3 46.3 48.7 46.4 43.1 44.7 46.2 44.0
55.0 56.9 56.5 55.4 57.4 59.5
NT 57.9
NT 58.0
56.0 60.0 57.0 56.3 58.3 56.5 56.2 56.8 56.7
18.3 19.9 18.4 18.5 18.7 19.8
NT 19.0
NT 19.3
18.0 19.6 19.3 18.5 19.2 19.2 18.5 18.8 19.2
33.2 35.0 32.5 33.4 32.5 33.3
NT 32.8
NT 33.2
32.1 32.7 33.9 32.9 33.0 33.9 32.9 33.1 33.9
RDW ARET PLT WBC % x 10a 3/m L x 10a 3/m L xlO~3/ML
11.9 11.4 13.0 11.4 11.7 12.2
NT 12.4
NT 12.9
12.7 12.0 11.7 12.4 12.0 11.8 10.9 12.2 11.0
124. 145. 149. 171. 186. 166.
NT 142.
NT 124.
165. 188. 177. 206. 163. 179. 130. 178. 149.
1024 916 958
1136 821 913 NT 988 NT 907
11.17 10.43
8.81 6.95 7.21 8.58
NT 6.50
NT 5.54
1258 872
1013 1020
905 1143 1050 1115 1177
9.71 9.81 10.50 11.51 9.97 8.17 12.13 9.45 7.19
657
Company Sanitized. Does not contain TSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
ANEU xlO|A3/m L
ALYM
x!0A3/h
AMON xlO
Individual Hematology Values
AEOS
ABAS
ALUC
ABLT
xlOA3/fiL xl0A3//iL xlOA3//iL x 10's3/m L
Female, Group: II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
1.21 2.73 1.34 1.08 0.81 2.09
NT 0.57
NT 0.82
9.23 6.92 6.92 5.53 6.02 5.86
NT 5.54
NT . 4.28
0.48 0.33 0.15 0.15 0.16 0.34
NT 0.21
NT 0.26
Female, Group : X - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
1.52 1.43 1.48 1.78 1.20 1.63 2.06 1.21 0.91
7.61 7.82 8.47 9.02 8.17 6.05 9.28 7.68 5.87
0.28 0.24 0.27 0.31 0.27 0.29 0.39 0.26 0.18
0.13 0.15 0.15 0.08 0.12 0.12
NT 0.07
NT 0.08
0.12 0.20 0.13 0.21 0.16 0.11 0.21 0.16 0.12
0.06 0.20 0.19 0.06 0.04 0.10
NT 0.06
NT 0.03
0.13 0.08 0.05 0.12 0.07 0.07 0.07 0.06 0.06
0.07 0.11 0.06 0.05 0.06 0.06
NT 0.06
NT 0.07
0.06 0.05 0.11 0.08 0.10 0.03 0.12 0.07 0.04
NT NT NT NT NT NT NT NT NT NT
NT NT NT NT NT NT NT NT NT
SPEC
DuPont-6554
658
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
COND
RBC x ! 0 a 6 /m L
HGB g/dL
Female, Group: II - 0 mg/kg - Day 183
648356 648357 648405 648422 648431
OK 8.64 16.0 NT NT NT OK 8.10 15.2 OK 8.74 15.9 OK 8.45 16.2
Female, Group: VI - 10 mg/kg - Day 183
648352 648365 648384 648385 648413
NT OK CLOT OK OK
NT 8.15
NT 7.71 8.01
NT 15.3
NT 14.1 14.8
Female, Group: VIII - 60 mg/kg - Day 183
648349 648360 648379 648386 648415
OK 8.32 15.6 OK 8.49 15.9 OK 7.89 15.6 NT NT NT OK 7.72 15.6
Female, Group: X - 300 mg/kg - Day 183
648358 648367 648373 648391 648411
OK 8.39 15.6 OK 7.62 14.9 OK 8.82 15.5 OK 8.67 16.3 OK 8.39 14.9
Individual Hematology Values
HOT MCV MCH MCHC % fL p g g/dL
47.7 NT
46.9 50.1 49.6
NT 46.7
NT 43.9 45.6
47.5 50.6 46.9
NT 46.7
47.7 45.3 48.2 48.7 46.6
55.2 NT
57.9 57.3 58.7
NT 57.3
NT 56.9 56.9
57.1 59.6 59.4
NT 60.5
56.9 59.4 54.7 56.2 55.5
18.5 NT
18.8 18.2 19.2
NT 18.8
NT 18.3 18.5
18.8 18.7 19.8
NT 20.2
18.6 19.6 17.6 18.8 17.8
33.5 NT
32.4 31.7 32.7
NT 32.8
NT 32.1 32.5
32.8 31.4 33.3
NT 33.4
32.7 32.9 32.1 33.5 32.0
RDW %
ARET X1CT3/ML
PLT
x 10a 3/m L
WBC
x 10a 3/m L
11.3 NT
12.1 11.6 11.5
NT 11.5
NT 12.2 12.0
10.9 11.6 13.2
NT 11.9
11.7 11.5 11.9 11.3 11.4
168. NT
126. 121. 159.
NT 160.
NT 121. 180.
165. 156. 173.
NT 155.
176. 168. 129. 147. 128.
959 6.95 NT NT
940 8.42 635 6.17 726 7.84
NT 667
NT 773 1198
NT 6.15
NT 8.28 13.36
830 1075
825 NT
498
4.43 9.18 5.99
NT 9.09
RNV 1129
858 1026
922
9.50 5.59 7.84 9.88 8.57
659
Company Sanltteod. Doss no<oootaix
CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
ANEU
ALYM
xlO'-l/pL x 1 0 a 3 / m L
AMON xlO ~3/nL
Individual Hematology Values
AEOS
ABAS
ALUC
ABLT
xl0,'3/aL xlO '3/m L x I O ^ / m L x ! 0 a 3 / m L
Female, Group: II - 0 mg/kg - Day 183
648356 648357 648405 648422 648431
0.76 NT
2.00 1.18 1.33
5.68 NT
5.86 4.54 6.10
0.26 NT
0.34 0.15 0.20
Female, Group: VI - 1C1 mg/kg - Day 183
648352 648365 648384 648385 648413
NT 0.99
NT 1.64 4.48
NT 4.53
NT 6.10 7.00
NT 0.29
NT 0.34 1.36
Female, Group : VIII - 60 mg/kg - Day 183
648349 648360 648379 648386 648415
0.53 2.49 1.09
NT 1.54
3.64 6.17 4.34
NT 6.98
0.07 0.35 0.20
NT 0.32
Female, Group: X - 300 mg/kg - Day 183
648358 648367 648373 648391 648411
1.66 0.78 1.10 1.99 1.13
7.33 4.33 6.31 7.17 7.06
0.25 0.32 0.15 0.37 0.15
0.17 NT
0.11 0.14 0.10
NT 0.15
NT 0.08 0.23
0.09 0.08 0.26
NT 0.12
0.11 0.10 0.12 0.25 0.14
0.04 NT
0.06 0.12 0.06
NT 0.12
NT 0.05 0.11
0.06 0.05 0.03
NT 0.05
0.08 0.04 0.09 0.05 0.03
0.05 NT
0.06 0.04 0.05
NT 0.07
NT 0.07 0.19
0.04 0.05 0.05
NT 0.08
0.06 0.03 0.07 0.07 0.04
NT NT NT NT NT
NT NT NT NT NT
NT NT NT NT NT
NT NT NT NT NT
SPEC
DuPont-6554
660
Company Sanitized. Does not contain TSCA CBt
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________________________________ DuPont-6554
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Male, Group: I - 0 mg/kg - Day 38
648220
--
--
-- __
i __
1
648225
-- __ __ i _ _
1
648238
_ __
i __
--
648246
--
__
__
i
1
648247 NT --
_
648255 NT _ _
__ _ _
_
_ __
648256
--
--
648294 NT __
:______ ______
_ ______ ______
1
648307
--
__ ______ ______
i ______
1
648315 -- -- --
--
i--
Male, Group: III - 60 mg/kg - Day 38
648227
648232 NT __
648252
--
__
648258
--
__
648269
--
--
648274
NT
648290
--
1
648299
__
648302
--
648303
--
1
Male, Group: V - 10 mg/kg - Day 38
__
__
______ __
1
1
_____ ______ ______ ______ __
_
______
--
i
______ ______
i_ _i ______
i
_____
i ______ i _____ i i"
______ ______ _____ ______ __ __ __
1 --
648221
_648224
--
--
__
648245
--
_ _ -- --
648273
--
--
--
--
648286
--
--
--
__
648288
--
--
__ __
648301
--
--
--
__
648309 -- -- _ _
648312
__
-- _ _
648313
--
--
--
i i __ i __ i-- 2 __ 1 -1 -1 __ 1 __
1 --
1 1 1
______
1 1
--
1
--
ACAN
2 2 2 2
______ _____
2
2 2
2
_____
2
_____
2
; i i
l i 2 2 2 1 2 3 3 2
TARG
______ ______ ______ _____ ______ ______ ______
_
______
--
______ ______ ______ __ __ __
______
--
__ __ -- __
__
--
RX HJB
__ _ --
_____ ______
______
_
_ __
__
__ __ __
__ --
--
__ ---
--
---
__
______ ______ ______
_____ ______
______
--
______ ______ ______ _____ ______ ______
__
--
__ __ -- __ __ __ ______ ______ __
661
Company Sanitized Does hu contain TSC CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Male, Group: VII - 60 mg/kg - Day 38
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
Male, Group: IX - 300 mg/kg - Day 38
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
NT
1
1
ACAN
TARG
DuPont-6554 RX HJB
662
Company Sanitized. Does not contain TSCA CBI
))
}
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____________________________________________________ __ ______________________________________________ DuPont-6554
Animal Number
SPEC
Male, Group: I - 0 mg/kg - Day 38
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
Male, Group: III - 60 mg/kg - Day 38
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
Male, Group: V - 10 mg/kg - Day 38
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
Individual Red Blood Cell Morphology Values
663
Company Sanitized. Does not contain TSCA CBi
) ))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________ ________________________________________ DuPont-6554
Animal Number
SPEC
Male, Group: VII - 60 mg/kg - Day 38
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
Male, Group: IX - 300 mg/kg - Day 38
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
Individual Red Blood Cell Morphology Values
664
Company Sanitized. Does not contain TSCA CEI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Male, Group: I - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
NT
Male, Group: III - 60 mg/kg - Day 92
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
--
2
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
ACAN
TARG
DuPont-6554 RX HJB
665
Company Sanitized. Does not contain TTSCA CBf
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Male, Group: VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
-- -- -- --- --- --- --- --- -- -- -- -- .1 ----
Male, Group: IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
---- -- --- ----- -- --- --- --- --- -- -- --
-- -- --- --- -- -1 --
----- -- --- ----
-- --- --- ----- --
--- -- -- -- ------
i 1 1 1 1 1 1 1 1 1
1 1 1 1 1 1 1 1 1 1
ACAN
3 4 3 4 3 3 3 2 4 3
TARG
DuPont-6554 RX HJB
666
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SPEC
Male, Group: I - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
Male, Group: III - 60 mg/kg - Day 92
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
Individual Red Blood Cell Morphology Values
DuPont-6554
667
Company Sanitized. Does not contain TSC CBI
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________
Animal Number
SPEC
Male, Group: VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
Male, Group: IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
Individual Red Blood Cell Morphology Values
)
DuPont-6554
668
Company Sanitized. Does not contain TSCA CBt
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
ACAN
Male, Group: I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
NO _ _
--
NO --
--
NO --
--
NO --
--
NO --
--
NO -- --
NO --
--
NO TRACE TRACE
NO --
--
NO --
--
Male, Group: IX - 300 mg/kg - Day 122
648216 NO _ _
648230 NO --
648241 NO --
648249 NO --
648261 NO --
648262 NO --
648282 NO --
648284 NO - -
648306
--
__
_
--- --
-- -- -- --
-- TRACE
_ _ TRACE MODERATE
-- TRACE
-- TRACE MODERATE
-- TRACE
-- TRACE
FEW
-- TRACE MODERATE -- _ _
-- TRACE
__
-- TRACE
- - TRACE -- - - MANY
-- TRACE
_ _ TRACE
MANY
--
TRACE
TRACE
-- MANY
-- TRACE
- - TRACE
FEW
-- TRACE -- -- MODERATE
______ TRACE ______ ______ MODERATE
-- TRACE
--
-- TRACE
-- TRACE
--
-- FEW
--
TRACE
TRACE
TRACE
FEW
-- TRACE
--
-- MANY
- - TRACE
--
-- FEW
- - TRACE
--
-- FEW
- - TRACE
- - MANY
__ __ __
__
TARG
--
-- --
--
-- --
--
--
--
______
--
-- -- -- -- -- ---
DuPont-6554
RX HJB
__
-- ---
--
-- FEW
-- --
--
-- -- --
-- -- --
-- ---
--
--
-- -- -- -- --
--
--
-- --
--
-- -- -- ---
669
Company Sanitized. Does ns! contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
SPEC
Male, Group: I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
FEW POIKILOCYTOSIS
Male, Group: IX - 300 mg/kg - Day 122
648216 648230 648241 648249 648261 648262 648282 648284 648306
Individual Red Blood Cell Morphology Values
1 DuPont-6554
670
Company Sanitized. Does not contain TSCA CB
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
ACAN
Male, Group: I - 0 mg/kg - Day 183
648219 NO -- 648226 NO -- 648228 NO --
648297 NT --
648298 NO --
-- -- --
---
Male, Group: V - 10 mg/kg - Day 183
648253 648254 648265 648283 648310
NO _ _
NO --
--
NO --
--
NO TRACE TRACE
NO --
--
Male, Group : VII - 60 mg/kg - Day 183
648268
NO
648279 NO --
648285 NO --
648296 NO --
648314 NO --
_ -- --
--
Male, Group: IX -- 300 mg/kg - Day 183
648234
NT
648240 NO --
648272 NO --
648287 NO --
648292 NO --
_
--
--
-- --
-- TRACE -- TRACE -- TRACE -- -- -- FEW
_ TRACE -- TRACE -- TRACE ---- -- TRACE
_ TRACE -- TRACE -- TRACE -- TRACE -- TRACE
__ -- TRACE -- TRACE -- TRACE -- TRACE
-- TRACE TRACE
-- -- FEW -- -- FEW -- __ --
-- TRACE MANY
_ FEW MANY -- -- FEW __ -- MODERATE FEW -- MODERATE
-- -- MODERATE
__ MODERATE -- MODERATE
MANY MANY
-- -- FEW -- -- MODERATE
-- FEW FEW
_ __ __
-- -- TRACE -- -- MANY -- -- MODERATE -- FEW MODERATE
TARG
-- --
--
---
_ -- -- ---
__ --- -- --
__ -- -- -- --
DuPont-6554
RX HJB
-- __ -- __ --
_ -- -- ---
-- -- -- -- __
__ --
--
--
--
671
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SPEC
Male, Group: I - 0 mg/kg - Day 183
648219 648226 648228 648297 648298
Male, Group: V - 10 mg/kg - Day 183
648253 648254 648265 648283 648310
Male, Group: VII - 60 mg/kg - Day 183
648268 648279 648285 648296 648314
Male, Group: IX - 300 mg/kg - Day 183
648234 648240 648272 648287 648292
Individual Red Blood Cell Morphology Values
DuPont-6554
672
Company Sanitized. Does not contain TSCA CB
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Female, Group: II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
Female, Group: IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
Female, Group: VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
NT
ACAN
TARG
DuPont-6554 RX HJB
673
Company Sanitized, Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
I
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
ACAN
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
Female, Group: X - 300 mg/kg - Day 39
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
1 -1 1 1
11 1
1 -1
11
1-- 1 1 -1--
11 1
12 --2
1 -1 1
1 1-- 1 1 -1
1-- 1--
41
1 21
1 11
--2 12
TARG
) DuPont-6554
RX HJB
674
Company Sanitized. Doss not contain TSCA C B I
))
H-24678: Subchronic Toxicity 90-Pay Oral Gavage Study in Rats____________________________________________________________________ ___________________________
DuPont-6554
Animal Number
SPEC
Female, Group: II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
1"POIKILOCYTOSIS
Female, Group: IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
Female, Group: VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
Individual Red Blood Cell Morphology Values
675
Company Sanitized. Does not contain TSCA CBI
)))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________________________________________________________________________ DuPont-6554
Animal Number
SPEC
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
Female, Group: X - 300 mg/kg - Day 39
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
1-HEMOGLOBIN CRYSTAL
Individual Red Blood Cell Morphology Values
676
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_________________________________________________________________________________________ DuPont-6554
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
Female, Group: IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
13 13 1 1 14 14 11 11 13 14
12 12 14 12 13 13 14 14 13 11
14 14 14 13 13 13 12 14 13 12
ACAN
3 3
2 3 1 1 2 2
3 2 2 1 2 1 1 2 1
2 3 1 2 1 2
1 1 2
TARG
RX HJB
677
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
Female, Group: X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
14 13 11 13 12 11 13 14 13 24
1 12 11 14 13 1 12 11 12 11
ACAN
2 1 1 1 1 1 1 2 2 3
1 2 1 1 2
1 1 2 1
TARG
DuPont-6554
RX HJB
678
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________________________________ DuPont-6554
Animal Number
SPEC
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
Female, Group: IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
1-POIKILOCYTOSIS
Individual Red Blood Cell Morphology Values
679
Company Sanitized. Does not contain TSCACBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats________________________________________________________________________________________ DuPont-6554
Animal Number
SPEC
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
Female, Group: X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
Individual Red Blood Cell Morphology Values
680
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Female, Group : II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
NO NO NO NO NO NO --
NO --
NO
_
--- -- ------
--
Female, Group : X - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
NO NO NO NO NO NO NO NO NO
_
__ --
--- -- ---
--
__ __
TRACE TRACE
-- TRACE
-- TRACE
-- TRACE
-- TRAC_E
-- TRACE __
-- TRACE
_ TRACE
-- TRACE __ TRACE
TRACE __ TRACE -- TRACE __ TRACE -- TRACE -- TRACE
TRACE TRACE TRACE
FEW MODERATE
TRACE TRACE
TRACE
MODERATE TRACE
FEW TRACE
ACAN
FEW FEW TRACE TRACE FEW FEW FEW
TARG
DuPont-6554 RX HJB
681
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SPEC
Female, Group: II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
Female, Group: X - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
Individual Red Blood Cell Morphology Values
DuPont-6554
682
Company Sanitized. Does not contain TSCA CBI
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats ____________________________________
Animal Number
NORM
ANIS
Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI
Female, Group: II - 0 mg/kg - Day 183
648356 648357 648405 648422 648431
NO --
NO NO NO
Female, Group: VI - 10 mg/kg - Day 183
648352 648365 648384 648385 648413
NO NT NO NO
Female, Group: VIII - 60 mg/kg - Day 183
648349 648360 648379 648386 648415
NO NO NO --
NO
Female, Group: x - 300 mg/kg - Day 183
648358 648367 648373 648391 648411
NO NO NO NO NO
---
__ TRACE -- TRACE -- TRACE
__
-- TRACE -- --- TRACE -- TRACE
__ TRACE -- TRACE -- TRACE ---- _ _ TRACE
_ _ TRACE -- TRACE -- TRACE -- TRACE -- TRACE
-- MODERATE __ -- -- -- __ FEW -- TRACE
_ -- TRACE -- ----- -- FEW
__ TRACE ---- -- FEW ---- -- TRACE
_ _ TRACE -- --- moderate
--
----
ACAN
FEW --
TRACE --
TRACE
-TRACE
-- FEW FEW
TRACE TRACE TRACE
-TRACE
TRACE TRACE
FEW TRACE TRACE
TARG
-- -- -- -- --
--- --- --
--- -- -- --
-- --
--
)
DuPont-6554
RX HJB
-- -- -- -- --
-- -- -- -- --
__ -- -- -- --
-- --
-- --
683
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SPEC
Individual Red Blood Cell Morphology Values
Female, Group: II - 0 mg/kg - Day 183
648356 648357 648405 648422 648431
Female, Group: VI - 10 mg/kg - Day 183
648352 648365 648384 648385 648413
Female, Group: VIII - 60 mg/kg - Day 183
648349 648360 648379 648386 648415
Female, Group: X - 300 mg/kg - Day 183
648358 648367 648373 648391 648411
DuPont-6554
684
Company Sanitized!. Does not contain TSC C0I
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Male, Group: X - 0 mg/kg - Day 38
648220
NORMAL
_
_
_
_
_
_
_
648225
NORMAL
__ __ _
--
648238
NORMAL
--
--
_ __ __ __
648246
NORMAL
__ __
-- __
648247 NT --
__ __ --
--
648255
NT
_ __ __ __ __ --
648256
NORMAL
__
__ --
-- --
648294
NT
__ __ --
--
648307
NORMAL
__
--
__ __ --
__ --
648315
NORMAL
--
-- --
-- --
"" --
Male, Group: III - 60 mg/kg - Day 38
648227
NORMAL
_
_
__ _
_
_
_
648232 NT --
__
__ __ __ --
648252
NORMAL
-- __ --
-- --
--
648258
NORMAL
__
__
--
__ __ --
--
648269
NORMAL
--
--
-- -- --
--
--
648274 NT -- -- --
__ -- -- --
648290
--
--- -- -- -- -- --
__
648299
NORMAL
-- -- -- -- __ --
648302
--
-- --
--
-- --
--
--
648303
NORMAL
--
--
--
-- -- --
Male, Group : V - 10 mg/kg - Day 38
648221 _ _ _ _ _ __ __ __
648224
NORMAL
--
--
--
-- -- --
--
648245
NORMAL
--
-- --
__ --
--
--
648273
NORMAL
--
--
----------
648286
NORMAL
--
--
--
--
--
--
--
648288
NORMAL
--
-- --
-- -- __
648301
NORMAL
--
--
--
--
--
--
--
648309
NORMAL
--
--
-- __ -- -- --
648312
NORMAL
--
--
--
--
--
--
--
648313
NORMAL
--
-- -- -- -- -- --
SPEC
TJTD PLATELET ADEQ PLATELET DECR PLATELET
685
Company Sanitized. Does not contain TSCA CBi
>
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
) DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Male, Group: VII - 60 ing/kg - Day 38
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
Male, Group: IX - 300 mg/kg - Day 38
648217 648218 648235
NORMAL NT
NORMAL
__ __ _ --_
_ _ _
_ _ _
___
__ _
__
__ __ __
648236 648239
NORMA_L_
__ --
_ __
_
__ __ _
_ _
648248 648275
NORMAL NORMAL
_ __
__
__
_ __ _ __
648289 648293
NORMAL
--
__ __ _
_ _
_ _
_
_
_ _
648308
NORMAL
--
--
__ _
__ __ __
SPEC
DECR PLATELET ADEQ PLATELET
686
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Male, Group: I - 0 mg/kg - Day 92
648220
NORMAL
648225
NORMAL
--
-- --
-- -- -- --
648238
NORMAL
--
--
--
-- -- -- --
648246
NORMAL
--
-- --
--
-- -- --
648247
NORMAL
--
--
-- .
-- -- --
648255
NORMAL
--
-- -- --
-- __ --
648256
NORMAL
__
__
__
--
__
--
648294 NT -- -- -- -- __ -- __
648307
NORMAL
__
--
__ __ --
648315
NORMAL
--
--
-- --
-- -- --
Male, Group: III - 60 mg/kg - Day 92
648227
NORMAL
648232
NORMAL
__
__
__
__
-- --
648252
NORMAL
--
__
__
__ -- --
648258
NORMAL
--
__
__ __ -- --
648269
NORMAL
--
__ __ __ _ -- __
648274
NORMAL
__
__
_
__
_
__
--
648290 -- -- --
_ __ __
--
648299
NORMAL
__ __ __ __ __ --
648302
NORMAL
--
--
__ -- __
648303
NORMAL
--
--
-- -- -- -- --
Male, Group: V - 10 mg/kg - Day 92
648221
NORMAL
648224
NORMAL
__ -- -- __ __ --
648245
NORMAL
--
__
--
--
-- --
648273
NORMAL
__
--
__
--
--
648286
NORMAL
__
-- -- -- --
648288
NORMAL
--
- - - - __ --
--
648301
NORMAL
--
__ - - __ -- --
--
648309
NORMAL
--
--
- - - - __ __ --
648312
NORMAL
--
-- --
--
-- --
--
648313
NORMAL
--
__
--
__
----
SPEC ADEQ PLATELET
687
Company Sanitized. Does noi contain TSCA CSI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
)
DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VG PCE GP BP
Male, Group: VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
__ --
-- --
--
-- ---
--
--
Male, Group: IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
NORMAL NORMAL NORMAL
__
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
______ -- -- --- --- -- ---
__ --
--
-- --
--
-- --
--
__
--
-- -- -- -- -- --- --
----
______ _ _
--
-- --
-- --
--
-- -- --
-- --
__ -- -- -- -- -- -- -- -- __
-- -- -- -- -- -- ---- ----
-- -- -- --
-- -- -- -- --
-- -- --
--
_ _ ______ _ _ _ _ _ _
-- -- -- -- --
---- ------
__ - -
--
-- -- -- -- --
-- - - - - __ - -
-- -- --
__
- - __ - - -- __
--
-- --
--
__ __ __ -- - -
SPEC UTD PLATELET
688
Company Sanitized. Does not contain TSCA CB!
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Male, Group: I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
YES YES YES YES YES YES YES YES YES YES
_ __
__ __ __ _ _ _ _
__ __ __ _
__ _
-- __ __ _ __ __ _
-- __ __ __ __ __ _
-- __ __
__ _
__
-- -- __ __ __ __ _
-- __ __ _ _ _ _
-- -- -- __ _ _ _
-- -- -- -- -- -- --
Male, Group: IX - 300 mg/kg - Day 122
648216
YES
_
_
__
648230
YES
--
--
__ _
_
__ _
648241
YES
--
____
648249 648261
YES YES
-- --
_ __ _ __ __ _
_ _
_ _
_ _
648262
YES
__ __ _ _ _ _
648282
YES
--
__ _
_
_
_
_
648284
YES
--
__ _
_
_
_
648306 -- -- __ __ _ _ _
)
DuPont-6554
689
Company Sanitized. Does not contain TSCA CBt
H-24678; Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Male, Group: I - 0 mg/kg - Day 183
648219
YES
--
----
----
-- --
648226
YES
--
--
-- - -
-- --
--
648228
YES
__
--
--
--
-- -- --
648297 NT - - -- -- -- -- -- --
648298 NO --
--
--
-- YES/DECR
--- --
Male, Group: v - 10 mg/kg - Day 183
648253
YES
______
______
__
648254
YES
--
--
--
648265
YES
--
--
--
648283
YES
--
--
--
648310
YES
--
-- --
__ __ --
---- ----
__ --
-- -- --
--
--
--
-- -- -- --
Male, Group: VII - 60 mg/kg - Day 183
648268 648279 648285 648296 648314
YES YES
NO YES YES
_
--
-- --
_
--
-- --
--
__ --
--
--
--
__ __ __ - -
-- -- ----
-- YES/DECR
----
-- --
--
--
-- ~~ -- --
Male, Group: IX - 300 mg/kg - Day 183
648234 NT _ _
_ __
_ __
_ __
648240
YES
--
--
--
-- -- --
--
648272 NO --
--
__
_ _ YES/DECR
--
--
648287
YES
--
--
-- -- --
--
--
648292
YES
__
-- --
-- --
__
SPEC
DuPont-6554
690
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Female, Group: II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
--
NORMAL NORMAL NORMAL NORMAL NORMAL
__
NORMAL NORMAL NORMAL
-- __ __
--
__ __
_ _ __
__ __ _
__ __
-- __ __
-- -- --
__ --
__ --
__
__ __
-- __
__ --
-- __ -- -- --
-- -- __
-- --
__ -
Female, Group : IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
--
NORMAL NORMAL NORMAL
______
__
__ --
--
__ --
__ __ --
-
-- -- -- -- -- --
-- -- -- -- --
-- --
__ -- --
-- -- -- --
-- __ _ -- __ _
-- -- __ __ --
-- __ __ __ __
Female., Group: VI - 10 mg/kg - Day 39
648345
NORMAL
__
--
_ _ ______ _ _ ______ ______
648366
NORMAL
-- --
______
648374
NORMAL
--
--
__
______
_ ______
648382
NORMAL
--
_ _ ______
_
648403
NORMAL
--
__
--
_ _ ______
648406 NT - -
--
_______
_____
648414
NORMAL
--
______ _____ ______ ______
648429
NORMAL
--
--
______
______ ______ _____
648433
NORMAL
_-- ______ ______ ______
______
648441 NORMAL _ _ - - ______ _____ ______ ______ _____
SPEC DECR PLATELET ADEQ PLATELET
DECR PLATELET
691
Company Sanitized. Does not contain TSCA CBS
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________
)
)
DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
-- --
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
-- --
-- -- -- --
-- --
-"
Female, Group : X - 300 mg/kg - ]
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
NORMAL NORMAL NORMAL
--
--
NORMAL NORMAL NORMAL NORMAL NORMAL
_
--
-- __ -- --
--
-- --
--
SPEC DECR PLATELET ADEQ PLATELET
UTD PLATELET ADEQ PLATELET
692
Company Sanitized, Does not contain TSCA CH
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________
)
) DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Female, Group: II - 0 mg/kg - Day 93
648351
NORMAL
--
--
__ _ _ _
648353
NORMAL
__ _ _ _ _
648370
NORMAL
__ _ _ _ _ _
648372
NORMAL
____
648393 648395
NORMAL NORMAL
.. __ _
_
_
_
_
__ _
648421
--
____
__
648423 -- __ __ _ _ _ _ _
648430
NORMAL
--
_
_
_
_
_
_
648436
NORMAL
--
--
__ _
_
_
__
Female, Group: IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
--
--
--- -- --__ __ __ --
--
Female, Group : VI - 10 mg/kg
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
--
NORMAL NORMAL
__ -----
-----
SPEC
UTD PLATELET ADEQ PLATELET
ADEQ PLATELET UTD PLATELET
UTD PLATELET
693
Company Sanitized. Does not contain TSCA C3!
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____________________________________________________________ ______________________________ DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL
--
NORMAL
-- -- -- -- -- --
-- --
-- -- --
-- __ -- __
__ __ -- -- __ --
-- -- --
--
--
-- __
__
-- __ -- -- ......
__ __ __
__
__ __ -- --
- __ __ __
Female, Group : X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
NORMAL NORMAL
__
NORMAL NORMAL NORMAL NORMAL NORMAL
__
NORMAL
___ ___ ___ ___ ___
__ __ --
__ __
-- -- -- __ __
__ -- -- __
__ --
-- --
-- -- -- -- --
__
-- --
--
-- __ __ -- --
__ __ --
-- -- -- --
SPEC
ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET
694
Company Sanitized. Does not contain TSC C8I
))
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________________________________ DuPont-6554
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP
Female, Group: II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
YES YES YES YES YES YES
YES
YES
Female, Group: x - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
YES YES YES YES YES YES YES YES YES
SPEC
Company Sanitized. Does not contain TSCA CB1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
Individual White Blood Cell / Platelet Morphology Values SM T0X DB VC , PCE GP BP
Female, Group: II - 0 mg/kg - Day 183
648356 648357 648405 648422 648431
YES
YES YES YES
Female, Group: VI - 10 mg/kg - Day 183
648352 648365 648384 648385 648413
YES NT
YES YES
Female, Group: VIII - 60 mg/kg - Day 183
648349 648360 648379 648386 648415
YES YES YES
YES
Female, Group: X - 300 mg/kg - Day 183
648358 NO --
--
--
- - YES/DECR
--
--
648367
YES
--
__
--
______
__
--
648373
YES
--
__
--
______ _ _ - - - -
648391
YES
__
--
__
--
-- -- --
648411
YES
--
--
__ - - - -
SPEC
DuPont-6554
696
Company Sanitized. Does not contain TSCA CBl
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
PHEM
PLIP
PICT
Male, Group: I - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
NONE NONE NONE NONE NONE NONE NONE
NSR NONE NONE
NONE NONE NONE NONE NONE NONE NONE
NT NONE NONE
NONE NONE NONE NONE NONE NONE NONE
NT NONE NONE
Male, Group: III - 60 mg/kg - Day 92
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Individual Coagulation
PT APTT sec sec
14.1 15.9 14.6 15.6 14.7 15.0 14.8
NT 15.9 14.9
15.2 14.6 15.2 14.2 14.6 16.1 14.2 16.8 14.8 14.7
15.1 14.9 15.6 15.1 15.2 15.1 14.4 15.2 14.7 15.6
19.8 18.4 19.2 20.7 17.4 19.4 17.0
NT 19.3 19.5
18.8 18.4 19.4 22.4 17.8 17.8 21.9 19.9 19.8 17.4
17.6 20.9 21.6 21.0 15.6 17.8 21.0 16.8 18.3 19.2
697
Values
DuPont-6554
Company Saafe,. Does not T3CA ^
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
PHEM
PLIP
PICT
Male, Group: VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Individual Coagulation Values
PT APTT sec sec
14.9 14.9 14.5 14.9 15.6 14.0 14.9 15.6 15.1 14.7
15.3 16.0 17.0 14.1 13.6 14.9 14.9 15.5 15.4 14.6
19.8 18.6 19.9 19.6 19.8 17.4 16.9 18.4 16.2 15.3
15.8 19.2 23.1 14.4 14.9 18.1 18.6 17.5 15.3 19.5
) DuPont-6554
698
Compaq Sanitized. Does not contain TSCA CBl
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
PHEM
PLIP
PICT
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group : IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Individual Coagulation Values
PT APTT sec sec
14.2 14.0 14.4 13.6 14.9 13.6 14.7 13.6 14.8 14.8
13.5 14.8 14.2 13.9 13.8 13.6 14.3 14.7 14.2 13.3
14.6 14.5 13.9 14.2 15.0 15.1 13.7 13.4 13.5 14.4
16.9 16.6 16.9 18.3 18.7 16.3 15.9 13.5 16.2 19.1
16.5 15.6 16.0 17.0 19.8 17.5 18.4 19.1 16.6 15.8
16.9 17.1 14.9 21.0 15.7 18.0 18.0 16.7 17.8 17.2
) DuPont-6554
699 W ^ a n , Sanitized. Dead no. onntmn TSCA OB.
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
PHEM
PLIP
PICT
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Individual Coagulation
PT APTT sec sec
15.4 15.4 13.5 14.4 15.6 14.6 14.1 14.9 13.7 14.3
13.9 14.5 13.6 13.4 13.7 14.7 13.7 13.4 13.5 13.4
17.2 16.3 19.1 15.2 16.5 18.3 16.4 15.2 14.6 14.5
19.0 20.0 14.7 17.4 15.7 17.4 15.5 13.5 14.9 15.2
700
Values
DuPont-6554
Company Sanitized. Does not contain 1SCA CM
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
SHEM
SLIP
Individual Serum and Piasi
SICT
AST IU/L
ALT IU/L
Male, Group: I - 0 mg/kg - Day 38
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
NONE SMALL
NONE SMALL SMALL
NONE SMALL
NSR TRACE TRACE
NONE NONE NONE NONE NONE NONE NONE
NT NONE NONE
NONE NONE NONE NONE NONE NONE NONE
NT NONE NONE
Male, Group: III - 60 mg/kg - Day 38
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
NONE TRACE
NONE NONE NONE TRACE NONE TRACE SMALL TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: V - 10 mg/kg - Day 38
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
SMALL NONE NONE
TRACE SMALL SMALL
NONE TRACE SMALL
NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
66 86 66 96 109 102 72 NT 72 108
88 117
70 73 92 134 67 83 91 80
109 64 88 91
110 100
75 81 98 82
27 32 30 42 33 34 26 NT 25 32
41 37 34 33 33 36 26 30 37 33
51 26 28 42 35 33 33 36 28 26
701
DuPont-6554
na Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BN mg/dL
CREA mg/dL
CHOL mg/dL
12.9 30.0 15.3 24.3 12.1 31.7 18.6
NT 25.1 17.1
21.9 24.2 15.9 17.6 19.7
9.2 19.5 28.6 15.3 20.1
48.2 16.6 18.5 20.3 18.4 17.8 16.9 20.9 12.2 17.4
121 0.12 103 0.10
88 <0.10 187 <0.10 162 0.14 120 <0.10 160 0.13
NT NT 132 0.11 131 0.12
115 0.12 127 0.11 113 0.13 163 0.10 178 0.10 156 <0.10 107 <0.10 160 0.10 196 <0.10 126 <0.10
162 0.12 127 0.12 134 <0.10 150 <0.10 119 0.13 166 0.13
94 <0.10 176 0.12 122 0.13 136 0.12
14 0.41 17 0.48 16 0.38 14 0.51 15 0.44 14 0.43 13 0.37 NT NT 13 0.41 16 0.39
14 0.41 13 0.38 15 0.36 14 0.42 16 0.34 18 0.45 15 0.47 12 0.49 15 0.41 14 0.36
15 0.55 12 0.31 13 0.34 17 0.43 14 0.40 16 0.40 11 0.30 13 0.42 13 0.32 13 0.31
83 60 73 85 72 65 66 NT 66 56
50 68 58 60 56 49 68 66 66 46
72 70 48 70 67 67 58 48 65 82
Company Sanitized. Does not contain TSCAGBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Plasma
SICT
AST IU/L
ALT IU/L
Male, Group: VII - 60 mg/kg - Day 38
648223
TRACE
NONE
NONE
119
94
648237
SMALL
NONE
NONE
96
49
648243
SMALL
NONE
NONE
122
59
648244
NONE
NONE
NONE
123
101
648259
SMALL
NONE
NONE
206
188
648266
TRACE
NONE
NONE
120
113
648270
SMALL
NONE
NONE
242
132
648280
SMALL
NONE
NONE
127
76
648300
SMALL
NONE
NONE
78
37
648305
TRACE
NONE
NONE
145
86
Male, Group: IX - 300 mg/kg - Day 38
648217
SMALL
NONE
NONE
164
99
648218
SMALL
NONE
NONE
193
128
648235
SMALL
NONE
NONE
115
76
648236
SMALL
NONE
NONE
91
56
648239
SMALL
NONE
NONE
149
163
648248
SMALL
NONE
NONE
197
135
648275
SMALL
NONE
NONE
150
132
648289
NONE
NONE
NONE
121
111
648293
SMALL
NONE
NONE
113
65
648308
SMALL
NONE
NONE
130
122
702
DuPont-6554
Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
28..5 22..6 16..9 26..8 42..3 26..0 31..0 21..6 21..6 26,.3
29.8 20.1 20.1 23.4 41.4 36.8 34.2 35.7 22.3 31.1
121 0..12 169 <0,.10 162 <0..10 189 <0..10 172 0,.10 215 0,.10 148 0..16 218 0,.10 217 0,.12 132 <0..10
198 0.11 251 0.13 250 <0.10 186 0.11 284 0.12 243 0.11 173 0.12 215 <0.10 231 0.13 186 <0.10
11 0..42 14 0..37 16 0..36 12 0..30 13 0..36 13 0..33 14 0..43 12 0..38 13 0..36 14 0,.35
21 0.39 15 0.46 16 0.36 15 0.39 17 0.46 17 0.40 16 0.41 14 0.41 13 0.43 12 0.27
68 50 51 51 74 46 53 50 57 82
54 70 53 64 65 52 92 52 64 43
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Piasi
TP g/dL
ALB g/dL
GLOB g/dL
Male, Group: I - 0 mg/kg - Day 38
648220
56 108 6.5 4.1 2.4
648225 57 80 6.4 4.3 2.1
648238
90 120 6.2 3.9 2.3
648246
39 102 6.9 4.2 2.7
648247 116 137 7.2 4.6 2.6
648255
69 109 7.1 4.2 2.9
648256
65 103 6.1 3.8 2.3
648294 NT NT NT NT NT
648307 53 88 6.7 4.3 2.4
648315 49 88 6.2 3.9 2.3
Male, Group: III - 60 mg/kg - Day 38
648227
53 111 6.2 4.1 2.1
648232
87 137 6.9 4.2 2.7
648252 59 83 6.4 4.2 2.2
648258 26 96 6.7 4.4 2.3
648269 76 95 6.7 4.2 2.5
648274
45 111 6.9 4.1 2.8
648290 116 162 7.3 4.5 2.8
648299 47 98 7.3 4.6 2.7
648302 40 99 6.5 4.1 2.4
648303 73 99 6.4 4.1 2.3
Male, Group: V - 10 mg/kg - Day 38
648221 140 154 6.9 4.1 2.8
648224
138
92 6.4 4.0 2.4
648245 47 89 6.4 4.1 2.3
648273
47 100 6.8 4.3 2.5
648286 73 93 6.2 3.8 2.4
648288
117
88 6.5 4.0 2.5
648301 59 97 6.3 3.9 2.4
648309 31 94 6.4 4.1 2.3
648312 43 92 6.5 4.1 2.4
648313
62 102 6.1 3.9 2.2
703
DuPont-6554
na Chemistry Values
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
10.5 10.8 10.9 10.8 11.5 10.9 10.8
NT 10.6
9.9
10.7 11.1 10.6 10.7 10.6 10.7 11.4 11.0 10.4 10.4
11.5 10.7 10.6 10.3 10.5 10.8 10.5 10.4 10.4 10.6
8.2 9.2 10.4 11.1 10.1 9.2 9-1
NT 8.7 7.8
142.5 147.8 144.2 144.4 145.8 142.5 145.6
NT 145.6 143.9
10.6 9.6 8.6 7.6 9.1
10.0 10.4
8.7 8.6 8.5
142.6 145.3 145.8 147.4 144.9 141.8 144.7 146.5 144.9 145.5
11.4 8.9 8.3 8.6 8.6 8.5 7.8 7.9 8.9 7.3
146.5 146.0 147.0 146.2 145.3 147.6 147.1 146.4 146.1 146.1
5.69 6.58 6.32 6.44 6.28 5.60 5.88
NT 5.52 5.62
100.4 100.7 101.0 101.5 103.1 101.6
99.7 NT
99.4 101.7
6.46 7.10 5.88 5.58 5.79 5.92 5.70 5.98 5.99 5.30
101.2 104.1 102.4 101.7
99.2 98.2 101.5 99.6 99.2 97.9
6.23 5.70 6.14 6.20 5.58 6.24 5.40 5.31 5.95 5.76
102.3 99.5
102.8 103.8 100.4 100.5 101.2 101.9 102.0 103.9
Company Sanitized. Does not contain TSCACBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Piasi
TP g/dL
ALB g/dL
GLOB g/dL
Male, Group: VII - 60 mg/kg - Day 38
648223
92 103 6.3 3.9 2.4
648237 88 94 6.2 3.7 2.5
648243 44 99 5.8 3.7 2.1
648244 78 99 6.3 4.0 2.3
648259 78 99 6.7 4.0 2.7
648266 173 105 5.8 3.9 1.9
648270
44 122 6.3 3.9 2.4
648280
78 109 5.9 3.6 2.3
648300 42 82 6.5 4.1 2.4
648305 54 97 6.3 4.0 2.3
Male, Group: IX - 300 mg/kg - Day 38
648217
47 112 5.8 3.8 2.0
648218
39 112 6.5 4.0 2.5
648235
78 106 6.6 4.1 2.5
648236 32 85 6.7 4.2 2.5
648239
49 109 6.7 4.2 2.5
648248
39 104 6.1 4.0 2.1
648275
80 102 6.7 4.4 2.3
648289 124 126 6.1 3.9 2.2
648293
30 111 6.6 4.3 2.3
648308
61 103 6.1 4.0 2.1
704
DuPont-6554
ma Chemistry Values
CALC mg/dL
XPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
10.0 10.1 10.0 10.9 10.3 10.4 10.4 10.5 10.3 10.4
10.3 10.4 10.6 10.5 10.4 10.3 10.4 11.2 10.5
9.9
8.8 7.6 9.4 9.2 8.3 8.4 9.7 11.5 9.4 9.6
146.5 144.0 143.9 145.7 147.9 144.4 143.2 143.1 145.2 144.6
11.0 11.2 10.3
9.4 9.7 9.6 8.5 11.2 10.1 8.6
146.2 143.6 145.2 147.0 144.9 143.5 143.1 146.9 144.1 146.1
5.83 5.87 6.38 5.43 6.04 5.95 5.96 7.04 5.77 6.26
103.0 101.8 103.0 101.3 101.1 101.2 103.6 100.0 103.1 102.1
8.09 7.38 5.95 6.29 6.13 6.52 5.86 6.76 6.91 5.95
104.0 103.2 100.6 101.3 102.3 100.7 100.7 104.3 102.6 101.3
Company Samtizad. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________
)
Animal Number
SHEM
SLIP
Individual Serum and Piasi
SICT
AST IU/L
ALT IU/L
Male, Group: I - 0 mg/kg - Day 92
648220
NONE
NONE
NONE
67
31
648225
NONE
NONE
NONE
71
25
648238
NONE
NONE
NONE
62
27
648246
TRACE
NONE
NONE
83
35
648247
TRACE
NONE
NONE
66
22
648255
NONE
NONE
NONE
73
29
648256
SMALL
NONE
NONE
80
27
648294
NSR
NT
NT
NT
NT
648307
TRACE
NONE
NONE
79
27
648315
NONE
NONE
NONE
88
36
Male, Group: III - 60 mg/kg - Day 92
648227
NONE
NONE
NONE
74
33
648232
NONE
NONE
NONE
75
24
648252
NONE
NONE
NONE
70
40
648258
NONE
NONE
NONE
87
28
648269
NONE
NONE
NONE
77
26
648274
NONE
NONE
NONE
82
27
648290
NONE
NONE
NONE
62
26
648299
NONE
NONE
NONE
70
28
648302
NONE
NONE
NONE
79
42
648303
NONE
NONE
NONE
76
34
Male, Group: V - 10 mg/kg - Day 92
648221
NONE
NONE
NONE
346
334
648224
NONE
NONE
NONE
90
41
648245
NONE
NONE
NONE
98
40
648273
NONE
NONE
NONE
90
61
648286
TRACE
NONE
NONE
110
59
648288
SMALL
NONE
NONE
181
153
648301
NONE
NONE
NONE
83
43
648309
NONE
NONE
NONE
84
44
648312
TRACE
NONE
NONE
104
59
648313
NONE
NONE
NONE
95
50
705
DuPont-6554
na Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
13.0 23.1 14.6 20.2 25.1 20.7 22.9
NT 30.1 26.7
22.8 15.0 20.9 19.2 16.5 25.7 17.4 19.5 17.0 17.8
116.8 17.3 18.9 21.1 24.1 39.2 22.2 19.0 24.6 18.0
85 0.11 70 <0.10 64 <0.10 128 0.13 89 0.12 73 0.11 90 0.10 NT NT 76 0.15 92 0.15
88 0.11 78 0.12 79 <0.10 107 0.13 109 0.13 92 0.10 63 0.11 110 0.12 164 0.12 93 0.13
134 0.10 75 0.13 82 0.11
122 0.15 80 0.11
128 0.14 80 0.10
103 0.14 95 <0.10
104 0.14
18 0.41 17 0.52 14 0.37 14 0.36 16 0.40 12 0.47 13 0.39 NT NT 16 0.44 15 0.42
16 0.37 13 0.25 17 0.32 18 0.34 16 0.36 16 0.43 13 0.39 14 0.37 17 0.37 15 0.33
12 0.26 12 0.29 15 0.28 17 0.42 14 0.36 16 0.35 14 0.28 13 0.32 13 0.31 16 0.35
111 65 81
104 93 99 88 NT 76 59
59 92 67 65 65 62 88 65 85 60
86 77 43 66 70 75 64 49 66 96
Company Sanitized, Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Plas:
SICT
AST I/L
ALT IU/L
Male, Group: VII - 60 mg/kg - Day 92
648223
NONE
NONE
NONE
422
494
648237
NONE
NONE
NONE
129
92
648243
SMALL
NONE
NONE
167
154
648244
NONE
NONE
NONE
410
365
648259
NONE
NONE
NONE
542
426
648266
TRACE
NONE
NONE
382
426
648270
SMALL
NONE
NONE
286
180
648280
TRACE
NONE
NONE
554
478
648300
TRACE
NONE
NONE
87
52
648305
NONE
NONE
NONE
294
247
Male, Group: IX - 300 mg/kg - Day 92
648217
NONE
NONE
NONE
246
187
648218
NONE
NONE
NONE
125
112
648235
NONE
NONE
NONE
187
169
648236
NONE
NONE
NONE
81
49
648239
TRACE
NONE
NONE
178
210
648248
TRACE
NONE
NONE
132
116
648275
NONE
NONE
NONE
189
217
648289
NONE
NONE
NONE
117
94
648293
NONE
NONE
NONE
97
58
648308
TRACE
NONE
NONE
130
116
706
DuPont-6554
ma Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
90..0 27..7 20..8 78..4 106,.6 69,.6 42..6 73..2 17..1 61..4
51.2 24.9 47.1 22.6 49.8 35.6 48.4 18.7 20.1 24.2
124 0..11 133 <0..10 159 0..14 218 0,.11 166 0..14 232 0..16 143 0..11 274 <0,.10 175 0,.14 151 0..11
240 0.14 230 <0.10 244 0.10 167 <0.10 288 0.12 262 0.11 278 0.18 206 0.12 206 <0.10 157 0.13
11 0..30 15 0..31 17 0..31 16 0..29 17 0..35 14 0..29 15 0..27 15 0,.37 16 0..37 15 0..35
17 0.34 15 0.27 14 0.27 19 0.42 17 0.41 17 0.34 18 0.35 14 0.30 14 0.28 13 0.26
58 49 54 69 73 59 48 55 52 81
50 61 62 52 82 49 94 37 58 48
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchroxiic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Piasi
TP g/dL
ALB g/dL
GLOB g/dL
Male, Group : I - 0 mg/kg - Day 92
648220 81 99 7.2 4.3 2.9
648225 94 93 6.8 4.4 2.4
648238
75 103 7.0 4.3 2.7
648246 36 90 7.3 4.1 3.2
648247 134 140 6.8 4.3 2.5
648255
90 106 7.6 4.3 3.3
648256
72 101 6.9 4.2 2.7
648294 NT NT NT NT NT
648307 52 92 7.0 4.3 2.7
648315 74 98 7.2 4.5 2.7
Male, Group: III - 60 mg/kg - Day 92
648227 69 93 6.8 4.3 2.5
648232 115 105 6.5 3.8 2.7
648252 73 95 6.9 4.4 2.5
648258 69 96 6.9 4.5 2.4
648269 54 92 7.1 4.3 2.8
648274 48 93 7.7 4.3 3.4
648290
121
96 7.3 4.3 3.0
648299
37 102 7.1 4.4 2.7
648302
73 101 7.1 4.2 2.9
648303
66 112 7.1 4.4 2.7
Male, Group: V - 10 mg/kg - Day 92
648221 108 118 6.7 3.8 2.9
648224
127
96 6.8 4.1 2.7
648245 53 98 6.5 4.0 2.5
648273
69 107 7.1 4.3 2.8
648286 110 104 6.3 3.7 2.6
648288 63 98 6.5 3.7 2.8
648301
72 152 6.4 3.8 2.6
648309 48 99 6.4 4.0 2.4
648312
40 107 6.7 4.0 2.7
648313
98 110 6.5 3.8 2.7
707
)
DuPont-6554
na Chemistry Values
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
PHEM
10.9 11.0 10.7 10.8 11.2 10.7 10.4
NT 10.7 10.6
10.5 10.6 10.7 10.8 10.7 10.8 10.7 10.7 10.6 10.8
10.5 10.4 10.3 10.7 10.2 10.6 10.8 10.2 10.3 10.4
8.0 147.8 7.5 150.3 6.6 149.1 7.5 147.6 9.0 146.0 6.7 148.7 7.5 148.8
NT NT 8.0 150.9 6.6 149.2
7.6 147.2 7.6 149.0 6.7 147.7 7.1 147.9 7.4 147.1 7.1 150.1 7.2 145.9 7.3 150.5 7.1 146.5 7.2 150.5
7.0 146.2 7.5 149.3 7.7 146.2 7.9 146.9 7.0 146.5 6.9 148.8 7.9 148.8 7.0 148.4 7.5 147.7 6.7 148.7
5.75 6.20 5.77 6.01 7.06 5.79 6.50
NT 6.78 6.38
103.7 100.9
99.9 98.6 99.9 99.9 100.1
NT 102.0 101.0
TRACE TRACE
NONE NONE NONE TRACE NONE
NSR NONE NONE
6.40 5.67 5.70 5.87 5.62 6.06 5.74 6.39 6.06 6.04
101.9 104.1 101.0 103.5 100.4 100.9
99.1 101.6 100.4
99.3
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
5.76 5.89 5.74 6.28 5.81 6.45 5.31 5.53 6.10 5.70
102.5 104.2 102.9 100.7 102.3 101.5 103.7 102.3 101.6 104.7
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Company Sanitized. Does not contain TSCA CBi
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats______
)
) DuPont-6554
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Plasma Chemistry Values
TP g/dL
ALB g/dL
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
Male, Group: VII - 60 mg/kg - Day 92
648223
89 113 6.5 4.2 2.3 10.4 7.9 149.4
648237 118 104 6.2 3.7 2.5 10.1 7.7 145.3
648243 46 97 6.3 4.0 2.3 10.1 7.5 146.0
648244 61 99 6.7 4.1 2.6 10.8 8.4 148.0
648259
67 103 7.0 4.2 2.8 10.0 7.2 149.2
648266 115 107 6.6 4.3 2.3 10.5 6.9 148.0
648270
46 104 6.3 3.9 2.4 10.2 7.5 147.3
648280
54 105 6.8 4.1 2.7 10.2 8.4 148.7
648300 31 86 6.3 4.0 2.3 10.1 7.6 148.6
648305
48 105 7.0 4.4 2.6 10.3 7.4 147.6
Male, Group: IX - 300 mg/kg - Day 92
648217
45 108 6.6 4.1 2.5 10.3 8.2 148.6
648218 79 99 6.7 4.2 2.5 10.2 7.9 147.8
648235
80 105 7.0 4.4 2.6 10.7 8.3 147.9
648236
32 123 6.5 4.2 2.3 10.6 8.4 146.8
648239
55 115 7.3 4.4 2.9 10.7 8.2 147.6
648248
29 106 6.2 4.1 2.1 10.2 8.6 147.1
648275 110 115 6.9 4.5 2.4 10.7 8.2 147.2
648289 122 109 6.6 4.2 2.4 10.6 8.1 147.8
648293
33 102 6.5 4.3 2.2 10.0 8.3 146.0
648308
48 112 6.6 4.1 2.5 10.5 8.3 147.6
K mmol/L
5.94 6.53 6.17 5.86 6.29 6.06 6.20 5.68 5.65 6.09
5.89 6.58 6.16 5.53 6.07 6.71 5.77 5.42 6.46 6.10
CL mmol/L
103.7 106.1 102.7 103.7 104.4 103.5 103.4 101.9 106.3 103.0
102.1 105.0 103.1 101.7 102.9 102.9 101.5 103.8 104.4 101.2
PHEM
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
708
Company Sanitized. Does not contain TSC CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
PLIP
PICT
Individual Serum and Plasma Chemistry Values PFLU
Male, Group: I - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
NONE NONE NONE NONE NONE NONE NONE
NT NONE NONE
NONE NONE NONE NONE NONE NONE NONE
NT NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 NSR 0.1 0.1
Male, Group: III - 60 mg/kg - Day 92
648227 648232 648252
648258 648269 648274
648290
648299 648302 648303
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE
NONE NONE
NONE
NONE NONE
NONE NONE
NONE
NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
DuPont-6554
709
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
PLIP
PICT
Individual Serum and Plasma Chemistry Values
PFLU
g/mL
Male, Group: VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group: IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.2 0.1 0.2 0.2 0.1 0.2 0.2 0.2 0.1 0.1
DuPont-6554
710
Company Sanitized. Does not contain TSC C8I
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Plasma
SICT
AST IU/L
ALT IU/L
Male, Group : I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
81 77 78 89 86 90 108 116 79 83
40 30 46 34 32 34 33 59 32 30
Male, Group: IX - 300 mg/kg - Day 122
648216
TRACE
NONE
NONE
102
25
648230
NONE
NONE
NONE
92
61
648241
NONE
NONE
NONE
435
391
648249
NONE
NONE
NONE
98
44
648261
NONE
NONE
NONE
119
95
648262
NONE
NONE
NONE
79
41
648282
NONE
NONE
NONE
128
101
648284
NONE
NONE
NONE
419
262
648306
NONE
NONE
NONE
126
69
711
DuPont-6554
Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
14.2 16.1 16.3 11.3 18.9 14.2 14.6 13.0 14.4 15.2
6.3 12.6 42.3 16.4 16.6 14.1 19.4 41.5 11.8
74 0.13 69 0.15 89 <0.10 65 0.12 64 0.13 68 <0.10 96 0.10 182 0.13 82 0.10 84 <0.10
63 <0.10 84 0.13 154 0.10 88 <0.10 99 <0.10 109 <0.10 98 <0.10 126 0.14 127 0.12
18 0.51 16 0.54 14 0.50 15 0.50 13 0.44 16 0.50 17 0.52 19 0.47 17 0.49 18 0.46
17 0.45 17 0.35 14 0.46 16 0.47 15 0.49 16 0.47 15 0.38 15 0.37 14 0.47
53 72 91 69 97 86 56 79 61 92
58 70 83 51 60 65 45 59 76
Company Sanitized. Does not contain TSCA CSl
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
TRIG xng/dL
GLUC mg/dL
Individual Serum and Plasma Chemistry Values
TP g/dL
ALB g/dL
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
Male, Group: I - 0 rag/kg - Day 122
648222 52 99 7.2 4.2 3.0 10.6 7.4 148.7
648233
84 102 7.5 4.4 3.1 10.6 8.7 147.8
648250
82 101 7.4 4.6 2.8 10.7 6.6 147.5
648257 65 99 7.2 4.2 3.0 10.3 7.3 146.4
648260 159 104 7.5 4.2 3.3 10.5 7.2 147.2
648264 49 97 7.6 4.2 3.4 10.2 7.7 148.0
648271
98 110 7.1 4.4 2.7 10.4 7.9 146.7
648277 44 95 7.0 4.3 2.7 10.0 8.6 145.3
648278 119 103 7.6 4.5 3.1 11.2 8.7 148.4
648311
66 101 7.2 4.2 3.0 10.5 8.6 146.3
Male, Group: IX - 300 mg/kg - Day 122
648216
30 101 7.3 4.3 3.0 10.0 8.0 146.1
648230
48 109 7.1 4.1 3.0 10.5 7.6 149.3
648241 65 93 6.8 4.2 2.6 10.1 7.7 147.1
648249
25 144 7.0 4.4 2.6 10.7 9.7 146.7
648261
91 100 6.8 4.3 2.5 10.3 8.0 147.7
648262 53 99 7.0 4.1 2.9 10.4 9.1 148.6
648282
68 101 6.5 4.1 2.4 10.2 7.9 147.4
648284 64 94 6.9 4.3 2.6 10.1 7.9 147.7
648306 116 123 7.2 4.5 2.7 10.3 8.4 145.1
K mmol/L
CL mmol/L
6.29 6.43 5.90 6.24 6.22 6.12 6.08 6.19 5.47 6.97
99.2 103.6
98.4 103.0
98.6 102.0 102.9 101.9 100.5 102.6
6.40 6.26 6.00 6.29 5.78 6.66 6.09 5.57 6.23
104.4 103.0 102.2 103.1 100.6 103.4 103.6 100.8 104.4
PHEM
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE
712
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
PLIP
PICT
Individual Serum and Plasma Chemistry Values
PFLU
g/mL
Male, Group: I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Male, Group: IX - 300 mg/kg - Day 122
648216 648230 648241 648249 648261 648262 648282 648284 648306
NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
DuPont-6554
713
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Piasi
SICT
AST IU/L
ALT IU/L
Male, Group: I - 0 mg/kg - Day 183
648219 648226 648228 648297 648298
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
Male, Group: V - 10 mg/kg - Day 183
648253 648254 648265 648283 648310
NONE NONE TRACE NONE NONE
,NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
Male, Group: VII - 60 mg/kg - Day 183
648268 648279 648285 648296 648314
NONE NONE NONE NONE TRACE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
Male, Group: IX - 300 mg/kg - Day 183
648234 648240 648272 648287 648292
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
116 61 88
117 92
60 99 88 91 214
132 154 125 130 144
520 193 1095
78 194
35 29 43 42 40
37 43 41 39 124
64 100
54 106
57
295 111 955
47 150
714
DuPont-6554
ma Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BDN mg/dL
CREA mg/dL
CHOL mg/dL
6.3 11.0 12.1 13.6 20.7
7.5 13.0 11.1 15.5 33.9
19.9 18.2 11.8 24.4 14.8
63.0 19.6 154.5 11.2 29.0
59 0.17 81 0.15 96 0.16 83 <0.10 87 0.19
91 0.10 125 0.19 117 <0.10 110 0.15
64 <0.10
100 0.10 101 0.10 102 <0.10 117 0.13
76 0.15
98 0.13 98 <0.10 135 0.12 79 0.11 113 0.11
15 0.40 14 0.39 14 0.44 15 0.44 16 0.55
15 0.38 15 0.44 15 0.44 15 0.47 14 0.43
12 0.39 16 0.39 13 0.40 14 0.45 48 0.83
20 0.44 16 0.36 14 0.32 13 0.36 12 0.41
61 89 51 64 71
84 110 107
75 101
189 77 66
108 147
68 41 66 69 73
Company Sanitized. Does not contain TSCA CBi
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
) DuPont-6554
Animal Number
TRIG mg/dL
GLUC mg/dL
individual Serum and Plasma Chemistry Values
TP g/dL
ALB g/dL
GLOB g/dL
; CALC mg/dL
IPHS mg/dL
NA mmol/L
Male, Group: I - 0 mg/kg - Day 183
648219 648226 648228 648297 648298
51 110 6.9 4.3 2.6 10.7 5.9 144.8 71 110 7.1 4.3 2.8 10.9 6.1 144.3 43 98 7.2 4.2 3.0 10.8 7.1 145.9 76 88 7.6 4.6 3.0 11.3 7.9 147.7 57 117 7.5 4.5 3.0 11.6 8.5 146.7
Male, Group: V - 10 mg/kg - Day 183
648253 124 105 6.5 3.9 2.6 10.8 7.5 145.4
648254 47 93 7.0 4.6 2.4 10.9 6.4 146.1
648265
71 118 7.2 4.4 2.8 11.1 6.8 146.2
648283
74 114 7.4 4.5 2.9 11.0 7.0 145.0
648310 113 117 7.0 4.3 2.7 11.2 6.3 145.6
Male, Group: VII - 60 mg/kg - Day 183
648268 150 112 7.1 3.8 3.3 11.3 7.1 147.2
648279
67 110 7.1 4.2 2.9 10.8 7.1 145.9
648285
32 120 6.6 4.0 2.6 10.4 7.0 146.2
648296 196 128 7.3 4.2 3.1 11.3 6.3 145.2
648314 55 81 6.4 3.6 2.8 10.3 7.2 145.3
Male, Group: IX - 300 mg/kg - Day 183
648234
60 120 7.0 4.4 2.6 11.3 9.8 146.0
648240
27 101 6.9 4.1 2.8 10.5 7.9 144.2
648272
101
96 7.3 3.9 3.4 10.6 7.4 144.1
648287
96 127 7.3 4.4 2.9 11.2 7.2 141.4
648292
60 108 7.0 4.0 3.0 11.0 6.9 145.0
K mmol/L
6.04 6.08 5.94 6.35 6.22
6.03 5.79 6.17 6.33 6.07
6.22 5.61 5.74 5.57 6.18
7.71 6.10 6.09 5.75 6.17
CL mmol/L
100.4 98.8 99.3
102.5 100.6
101.8 99.6 99.4
100.2 98.4
100.3 99.8
104.0 98.2 99.0
100.1 97.9
100.6 96.2 99.2
715
Company Sanizsd. Doos not contain TSCA CM
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Plasn
SICT
AST IU/L
ALT IU/L
Female, Group: II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
114 69 94
100 83 92 96 76 86 84
74 85 62 91 88 82 95 82 81 75
79 79 59 86 88 207 83 75 89 105
38 32 33 38 31 45 33 33 29 27
33 24 25 29 28 28 30 30 32 33
28 30 25 37 23 82 27 24 34 60
716
DuPont-6554
na Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
23.9 11.6 17.8 14.9 21.3 19.1 21.3 19.4 20.8 21.1
15.2 15.4 13.8 22.9 17.0 14.7 14.8 23.3 15.8 17.9
16.6 16.2 14.1 19.6 17.0 41.2 16.8 17.2 12.9 21.2
77 0.17 77 0.14 148 0.14 94 0.16 97 0.20 92 0.19 97 0.11 60 0.19 100 0.18 78 0.12
66 0.22 98 0.11 51 0.12 98 0.17 92 0.11 107 0.15 89 0.16 85 0.18 110 0.14 88 0.19
86 0.13 87 0.10 87 0.12 93 0.15 70 0.14 97 0.20 103 0.18 58 0.11 89 0.13 60 0.14
18 0.54 18 0.48 20 0.50 21 0.43 21 0.51 15 0.42 18 0.46 16 0.52 20 0.50 16 0.51
17 0.48 19 0.43 14 0.45 15 0.44 13 0.42 15 0.40 17 0.42 18 0.52 15 0.49 21 0.58
17 0.47 17 0.50 14 0.43 16 0.44 16 0.44 25 0.54 16 0.41 16 0.44 16 0.42 16 0.40
57 50 75 122 70 102 79 127 78 107
78 72 97 70 88 60 52 69 75 89
65 60 75 55 56 55 72 58 83 74
Company Sanitized. Does not contain ISCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Piasi
SICT
AST IU/L
ALT IU/L
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
TRACE NONE NONE NONE
TRACE TRACE
NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group : X - 300 mg/kg - Day 39
87 96 67 69 118 74 85 77 61 75
28 32 21 28 40 28 38 31 29 29
648347
NONE
NONE
NONE
496
145
648363
NONE
NONE
NONE
73
36
648376
NONE
NONE
NONE
78
24
648388
NONE
NONE
NONE
93
30
648392
NONE
NONE
NONE
89
40
648400
NONE
NONE
NONE
106
29
648407
NONE
NONE
NONE
73
41
648412
NONE
NONE
NONE
72
28
648435
TRACE
NONE
NONE
80
36
648438
NONE
NONE
NONE
70
36
717
DuPont-6554
na Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
12.8 18.6 12.2 12.9 21.7 17.0 12.7 15.0 14.8 14.4
126.0 13.9 15.4 19.1 15.9 9.9 18.5 16.4 17.8 15.1
72 0.12 90 <0.10 102 <0.10 67 <0.10 93 0.12 76 <0.10 78 0.11 62 0.13 73 0.22 70 0.15
60 0.13 47 <0.10 78 0.12 66 <0.10 126 0.10 80 <0.10 53 0.20 59 0.11 84 0.17 65 <0.10
17 0.48 19 0.51 15 0.45 16 0.46 16 0.53 15 0.38 14 0.40 15 0.49 16 0.46 17 0.36
14 0.42 16 0.45 17 0.38 13 0.31 16 0.48 15 0.46 17 0.47 11 0.39 19 0.47 19 0.46
57 68 75 67 65 66 76 95 83 64
93 68 92 92 80 44 85 66 67 81
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
1
DuPont-6554
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Plasma Chemistry Values
TP g/dL
ALB g/dL
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
Female, Group: II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
41 108 7.5 5.2 2.3 11.5 8.3 144.1 31 88 7.8 5.3 2.5 11.5 7.3 142.5 24 98 7.1 4.8 2.3 11.6 8.8 143.9 60 96 7.2 5.0 2.2 10.9 8.2 139.9 45 89 6.7 4.8 1.9 10.4 7.8 142.9 53 99 7.1 4.7 2.4 11.0 7.2 142.4 47 98 7.1 4.7 2.4 10.9 8.2 144.1 77 87 8.4 5.6 2.8 11.7 6.7 140.0 25 107 7.4 4.9 2.5 11.1 8.4 143.8 50 110 7.5 4.9 2.6 11.2 8.6 145.0
Female, Group: IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
38 100 7.1 5.1 2.0 11.2 6.4 140.6 36 84 7.1 4.4 2.7 10.6 7.1 142.8 56 116 7.8 5.3 2.5 10.8 6.9 143.2 47 112 8.1 5.7 2.4 11.4 7.9 143.4 34 108 7.2 4.8 2.4 10.7 7.5 144.7 26 100 6.9 5.0 1.9 10.8 6.5 140.9 30 97 6.7 4.6 2.1 10.8 7.0 141.5 35 103 7.4 5.0 2.4 12.0 9.5 144.9 39 100 7.9 5.3 2.6 11.3 7.4 140.8 34 104 7.7 5.5 2.2 11.1 7.3 142.5
Female, Group: VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
35 103 7.3 4.8 2.5 11.0 6.7 144.8
30 96 7.0 4.6 2.4 10.7 7.7 143.9
61 113 7.5 5.1 2.4 11.2 6.7 142.6
37 117 7.4 4.6 2.8 11.5 7.9 144.4
31 91 6.9 4.9 2.0 10.7 6.7 143.3
37
87
7.3
5.1
2.2
11.3
10.3
144.3
37 118 7.5 5.0 2.5 11.2 7.5 143.3
27 119 6.7 4.8 1.9 10.5 7.3 142.6
42 95 7.2 4.6 2.6 10.9 7.6 141.9
46 106 7.5 4.9 2.6 11.0 6.9 144.7
K mmol/L
6.06 5.81 5.09 5.68 5.86 4.91 6.25 6.07 5.54 6.80
5.61 5.38 5.11 5.22 5.00 4.76 5.60 6.47 5.26 5.71
5.10 5.91 5.52 5.88 5.17 6.10 5.14 5.40 5.41 5.53
CL mmol/L
101.3 98.9
102.7 99.6
100.7 98.8 95.7 95.7
102.2 102.8
97.2 99.6 102.7 97.8 100.7 100.2 102.3 99.5 97.3 98.8
101.1 98.7 99.0
100.4 100.9
96.2 100.2 101.8
99.4 99.5
718
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
)
DuPont-6554
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Plasma Chemistry Values
TP g/dL
ALB g/dL
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL rnmol/L
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
29
105
7.2
4.7
2.5 10.7
7.5 141.0
5.33
98.4
20
88
7.2
4.6
2.6 11.0
8.9 142.1
5.37
101.9
40
105
7.6
5.4
2.2 10.8
7.3 142.9
5.19
100.5
40
101
6.8
4.7
2.1 10.9
6.5 144.4
5.12
98.7
36
97
7.4
4.6
2.8 11.5
9.7 143.6
5.70
101.2
39
95
7.2
4.8
2.4 11.0
8.5 144.2
5.37
99.2
41
107
6.8
4.8
2.0 10.6
6.8 140.7
5.48
101.0
49
100
7.4
5.0
2.4 11.0
7.2 143.0
5.09
99.4
61
104
7.7
5.3
2.4 11.7
7.0 141.9
5.25
97.2
63
107
7.0
4.7
2.3 11.0
8.0 141.0
5.62
99.6
Female, Group: X - 300 mg/kg - Day 39
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
33
99
7.5
5.0
2.5 11.3
7.0 142.8
5.39
103.1
23
100
7.2
4.9
2.3 11.0
7.6 144.6
5.44
99.9
51
106
7.1
4.8
2.3 10.8
6.9 142.8
5.14
101.6
56
127
6.8
4.6
2.2 11.6
9.8 143.7
5.13
104.0
42
95
7.4
5.0
2.4 11.2
7.5 141.3
5.32
97.9
25
96
6.9
4.9
2.0 10.8
7.6 141.5
5.47
100.1
34
98
7.7
5.5
2.2 11.5
7.8 142.4
5.73
98.6
37
82
7.2
4.8
2.4 11.3
7.7 143.3
6.18
99.7
53
114
7.1
5.0
2.1 11.2
7.9 143.2
6.42
100.7
50
103
7.3
5.0
2.3 10.9
6.9 140.9
5.34
99.2
719
Company ffcmKbed. Doe ,,of cornel., tsca CBt
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Plasma
SICT
AST IU/L
ALT IU/L
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
76 75 92 78 84 76 94 86 66 87
73 79 58 83 104 87 83 86 72 87
77 81 99 93 93 96 93 88 87 140
34 36 33 36 26 30 41 36 28 26
39 25 27 43 51 33 39 42 39 35
28 32 57 42 29 39 37 30 43 87
720
)
DuPont-6554
Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
12.6 11.3 12.8 13.3 15.8 13.1 19.5 18.6 13.5 17.7
15.6 13.4 12.3 16.8 22.4 12.2 22.2 13.2 14.0 12.9
12.2 14.4 23.5 11.5 16.7 20.4 15.7 11.9 16.5 30.1
42 0.18 40 0.17 88 0.15 69 0.17 61 0.18 50 <0.10 51 0.13 50 0.18 54 0.21 50 0.12
40 0.16 47 0.15 26 0.11 49 0.17 44 0.12 73 0.11 50 0.14 47 0.16 57 0.21 36 0.21
49 0.11 56 <0.10 30 0.13 48 0.11 51 0.14 55 0.18 43 0.15 37 0.12 55 0.11 31 0.13
18 0.49 18 0.54 20 0.55 20 0.44 18 0.51 19 0.47 19 0.49 20 0.55 19 0.53 16 0.53
18 0.46 19 0.50 15 0.46 20 0.49 16 0.47 15 0.48 17 0.56 18 0.53 17 0.56 19 0.54
18 0.48 18 0.52 19 0.45 16 0.54 18 0.43 22 0.53 17 0.47 20 0.58 18 0.46 19 0.49
76 61 88 157 64 96 74 112 120 102
132 72 95 74
106 73 71 70 83
101
69 70 95 70 51 61 92 58 88 77
Company Sanitized. Does not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Plasma
SICT
AST IU/L
ALT IU/L
Female, Group: VIII - 60 mg/kg - Day 93
648348
NONE
NONE
NONE
78
26
648354
NONE
NONE
NONE
96
29
648362
NONE
NONE
NONE
77
41
648368
TRACE
NONE
NONE
70
23
648380
NONE
NONE
NONE
76
39
648381
NONE
NONE
NONE
88
32
648401
NONE
NONE
NONE
76
34
648417
NONE
NONE
NONE
77
30
648432
NONE
NONE
NONE
73
47
648440
NONE
NONE
NONE
68
36
Female, Group : X - 300 mg/kg - Day 93
648347
NONE
NONE
NONE
248
100
648363
NONE
NONE
NONE
78
34
648376
NONE
NONE
NONE
89
30
648388
NONE
NONE
NONE
77
32
648392
NONE
NONE
NONE
74
32
648400
NONE
NONE
NONE
89
35
648407
NONE
NONE
NONE
67
29
648412
NONE
NONE
NONE
117
67
648435
NONE
NONE
NONE
135
77
648438
NONE
NONE
NONE
166
113
721
)
DuPont-6554
Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
13.6 9.2
14.8 10.4 14.9 14.4 11.7 14.8 18.8 16.5
42.8 18.5 13.2 15.6 12.3 13.9 16.7 20.6 29.0 32.8
43 0.15 44 <0.10 61 0.11 39 0.11 47 0.15 42 0.11 47 0.12 36 0.17 36 0.16 38 0.14
36 0.13 33 0.11 40 0.10 52 0.12 70 0.10 73 0.12 35 0.13 33 <0.10 39 0.14 41 0.12
16 0.57 19 0.52 16 0.50 19 0.47 15 0.53 15 0.51 13 0.42 18 0.53 16 0.47 17 0.48
14 0.47 14 0.54 15 0.48 14 0.42 18 0.50 17 0.41 16 0.55 18 0.49 26 0.58 21 0.52
77 76 94 69 67 73 72 85 114 76
120 65
102 98 93 43 89 80 91 82
Company Sanitized. Does not contain TSCA CM
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Plasma Chemistry Values
TP g/dL
ALB g/dL
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
Female, Group: II - 0 mg/kg - Day 93
648351
44 103 8.3 5.6 2.7 11.1 5.1 144.9
648353 48 84 8.1 5.6 2.5 11.3 6.6 143.5
648370 41 98 7.4 4.9 2.5 10.8 6.2 145.2
648372 225 103 8.0 5.6 2.4 11.4 7.7 141.8
648393 35 96 6.7 4.8 1.9 10.2 7.1 141.3
648395 43 92 7.5 5.0 2.5 10.9 6.5 143.3
648421 76 91 7.2 4.9 2.3 11.3 7.6 145.2
648423 84 98 8.6 5.8 2.8 11.3 6.1 144.2
648430
77 102 8.6 6.0 2.6 11.3 4.9 142.2
648436 44 99 7.7 5.0 2.7 10.7 4.6 143.6
Female, Group : IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
37 105 8.2 5.8 2.4 11.4 6.1 142.0 48 92 7.3 4.9 2.4 10.4 5.3 143.1 43 104 8.2 5.7 2.5 11.0 6.0 144.7 69 106 8.0 5.9 2.1 11.4 5.8 142.3 49 109 8.2 5.5 2.7 10.9 6.6 143.0 28 98 7.6 5.4 2.2 10.6 5.2 143.6 50 104 7.6 5.2 2.4 11.6 8.2 145.8 28 99 7.6 5.1 2.5 10.9 4.7 143.7 31 101 8.3 5.7 2.6 11.0 6.2 143.1 41 101 8.4 5.9 2.5 11.2 6.6 142.5
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
29 91 7.4 4.9 2.5 10.9 6.7 143.0 32 99 7.4 4.9 2.5 10.5 6.3 145.5 58 97 8.5 5.8 2.7 11.7 6.8 143.8 46 91 7.7 4.9 2.8 10.8 5.5 142.6 40 87 7.1 4.9 2.2 10.8 6.8 146.2 29 93 8.0 5.5 2.5 10.7 5.8 145.7 38 98 7.3 5.1 2.2 10.5 5.6 143.9 23 121 7.0 4.7 2.3 10.7 7.4 143.9 54 103 7.7 4.9 2.8 11.3 6.3 140.3 44 101 7.4 5.0 2.4 10.4 5.2 141.8
K mmol/L
5.07 5.64 5.29 4.92 6.07 4.73 6.15 5.36 5.48 5.04
5.26 5.06 5.37 5.40 5.41 4.90 6.49 5.42 4.71 4.78
5.45 5.53 5.47 4.93 5.42 5.03 4.83 5.46 5.31 5.01
CL mmol/L
101.3 101.8 102.3
96.5 99.8 101.1 98.5 99.4 99.4 102.3
98.6 99.9 102.0 96.8 98.6 101.2 102.9 100.8 97.9 97.9
103.6 101.6 100.9
98.1 100.6 101.6 100.0 104.1
97.5 99.9
PHEM
NONE NONE NONE NONE NONE NONE NONE TRACE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
722
Company Sanitized. Does not contain TSCA GBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Piasi
TP g/dL
ALB g/dL
GLOB g/dL
Female, Group: VIII - 60 mg/kg - Day 93
648348
39 114 8.0 5.1 2.9
648354 35 88 7.4 4.7 2.7
648362 32 88 9.0 6.4 2.6
648368 26 96 7.3 4.9 2.4
648380 67 94 7.8 5.2 2.6
648381 32 89 7.6 5.0 2.6
648401
59 105 7.4 5.3 2.1
648417
37 101 7.7 5.3 2.4
648432
121
92 8.2 5.7 2.5
648440
84 108 7.5 5.1 2.4
Female, Group: X - 300 mg/kg - Day 93
648347
44 104 8.4 5.8 2.6
648363
51 108 8.4 5.8 2.6
648376
46 112 7.4 5.2 2.2
648388
92 101 7.3 5.0 2.3
648392 39 95 7.9 5.3 2.6
648400 32 97 7.4 5.3 2.1
648407
35 103 8.0 5.7 2.3
648412 34 96 7.7 5.4 2.3
648435
115
98 8.0 5.6 2.4
648438
57 105 7.9 5.4 2.5
723
DuPont-6554
na Chemistry Values
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
PHEM
10.9 10.3 11.7 10.7 10.9 10.5 10.7 10.8 11.6 10.7
11.4 11.2 10.5 10.7 11.0 10.9 11.3 10.7 11.4 10.9
5.6 145.1 5.7 142.4 6.1 144.0 5.4 144.7 5.5 144.0 6.2 143.5 6.0 143.1 5.4 145.3 6.0 142.1 6.0 143.5
4.4 143.7 6.3 149.0 5.4 141.9 6.8 144.7 5.4 143.0 6.7 144.3 6.9 142.5 5.2 143.1 6.4 142.0 6.5 142.9
4.87 5.65 5.03 5.75 5.24 5.20 5.23 5.21 5.01 5.09
101.0 101.4
97.9 100.9 100.0 102.1 102.8 102.2
97.9 99.9
4.72 5.07 5.33 4.93 5.04 5.43 5.28 5.40 4.75 5.11
101.4 103.2 101.9 101.7 100.2 100.2
97.3 100.1
97.3 102.7
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____
))
___________________________________________ DuPont-6554
Animal Number
PLIP
PICT
Individual Serum and Plasma Chemistry Values
PFL
ig/mL
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Female, Group : IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1
724
Company Sanitized. Does not contain TSCA CBf
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________
)
) ________________________________ DuPont-6554
Animal Number
PLIP
PICT
Individual Serum and Plasma Chemistry Values
PFLU ig/mL
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Female, Group: X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
725
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
SHEM
SLIP
Individual Serum and Plasn
SICT
AST IU/L
ALT IU/L
Female, Group: II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
NONE NONE NONE NONE NONE NONE NONE NONE
NSR NONE
NONE NONE NONE NONE NONE NONE NONE NONE
NT NONE
NONE NONE NONE NONE NONE NONE NONE NONE
NT NONE
Female, Group: X - 300 mg/kg - Day 122
in 112
72 61 71 52 131 58 NT 56
72 45 27 28 29 24 40 25 NT 35
648350
NONE
NONE
NONE
89
47
648359
NONE
NONE
NONE
128
69
648378
NONE
NONE
NONE
80
33
648383
NONE
NONE
NONE
329
218
648387
NONE
NONE
NONE
77
32
648398
NONE
NONE
NONE
89
53
648399
NONE
NONE
NONE
91
44
648419
NONE
NONE
NONE
144
78
648427
NONE
NONE
NONE
83
40
726
DuPont-6554
ia Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
19.3 18.6 11.8
9.9 17.4 11.4
8.4 14.1
NT 15.9
13..8 25,.0 14,.6 46..9 14,.8 14..0 10..8 23..2 14.,6
31 0.12 36 <0.10 37 0.11 38 0.12 30 0.18 31 0.10 38 0.14 33 0.10 NT NT 27 0.12
28 0..13 42 0..12 73 0..11 57 0..10 73 <0,.10 36 0..12 38 <0..10 43 <0..10 27 0..14
21 0.62 17 0.53 17 0.55 18 0.64 15 0.58 13 0.50 16 0.56 14 0.47 NT NT 13 0.57
17 0,.54 18 0..63 27 0..70 20 0..51 16 0..51 23 0..56 18 0..51 18 0..54 16 0..55
108 96 50
108 100 110
83 114
NT 128
74 85 57 131 83 118 74 80 86
Company Sanitized. Does not contain TSCA GBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Plasma Chemistry Values
TP g/dL
ALB g/dL
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
Female, Group: II - 0 mg/kg - Day 122
648346
76 124 8.8 5.9 2.9 11.4 6.1 143.7
648355 102 100 9.2 6.2 3.0 11.7 5.5 144.6
648389 61 93 7.8 5.2 2.6 10.8 6.8 145.3
648394
61 108 8.2 5.5 2.7 10.9 5.4 144.3
648404 145 115 8.9 6.0 2.9 10.8 5.9 145.9
648425
99 103 8.8 5.8 3.0 11.2 6.9 143.9
648426 280 121 8.3 5.5 2.8 11.1 7.6 142.6
648434 174 105 8.5 5.5 3.0 11.2 6.0 147.3
648439 NT NT NT NT NT NT NT NT
648442 277 109 9.3 6.0 3.3 11.3 5.8 145.7
Female, Group : X - 300 mg/kg - Day 122
648350
37 103 8.0 5.3 2.7 10.9 7.4 148.4
648359
94 111 8.9 6.0 2.9 11.0 6.9 144.9
648378 38 97 7.8 5.4 2.4 10.4 6.8 143.7
648383 47 89 7.9 5.1 2.8 10.7 6.5 146.1
648387
87 107 7.7 5.3 2.4 10.7 5.9 146.0
648398 116 101 8.6 5.8 2.8 11.1 6.1 145.8
648399
46 102 7.4 4.8 2.6 10.4 6.1 145.9
648419 42 98 7.8 5.2 2.6 10.9 7.2 147.1
648427
80 105 8.0 5.6 2.4 11.0 5.4 145.5
K mmol/L
4.86 4.51 5.55 5.29 5.60 5.41 6.34 5.44
NT 4.83
5.45 5.75 5.46 5.28 5.02 4.89 5.82 5.64 5.21
CL mmol/L
100.4 95.2
100.8 101.3 103.6
97.3 103.2 100.4
NT 98.8
102.5 100.6 101.8
98.4 101.4
98.7 103.9 102.0 102.2
PHEM
NONE NONE NONE NONE NONE NONE NONE NONE
NSR NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE
727
Company Sanitized. Does not contain TSCA CBi
) ))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________________________________________________________________________ DuPont-6554
Animal Number
PLIP
PICT
Individual Serum and Plasma Chemistry Values
PFLU (g/mL
Female, Group: II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
NONE NONE NONE NONE NONE NONE NONE NONE
NT NONE
NONE NONE NONE NONE NONE NONE NONE NONE
NT NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 NSR 0.1
Female, Group: X - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0 .1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
728
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
SHEM
SLIP
Individual Serum and Piasi
SICT
AST IU/L
ALT IU/L
Female, Group: II - 0 mg/kg - Day 183
648356
NONE
NONE
NONE
109
53
648357
NSR
NT
NT
NT
NT
648405
NONE
NONE
NONE
462
108
648422
NONE
NONE
NONE
138
83
648431
NONE
NONE
NONE
150
67
Female, Group: VI - 10 mg/kg - Day 183
648352
NSR
NT
NT
NT
NT
648365
NONE
NONE
NONE
218
115
648384
TRACE
NONE
NONE
136
57
648385
NONE
NONE
NONE
82
38
648413
NONE
NONE
NONE
822
610
Female, Group: VIII - 60 mg/kg - Day 183
648349 648360 648379 648386 648415
NONE NONE NONE
NSR NONE
NONE NONE NONE
NT NONE
NONE NONE NONE
NT NONE
113 82
148 NT
176
55 38 90 NT 95
Female, Group: X - 300 mg/kg - Day 183
648358 648367 648373 648391 648411
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
122 83 72 86 95
54 49 43 45 36
729
DuPont-6554
na Chemistry Values
SDH IU/L
ALKP IU/L
BILI mg/dL
BON mg/dL
CREA mg/dL
CHOL mg/dL
22.4 NT
44.8 21.4 24.9
NT 38.5 20.3 12.7 191.0
16.1 15.8 28.0
NT 35.6
14.5 17.8 13.6 11.6 11.4
54 0.11 NT NT 81 0.16 44 0.14 51 0.16
NT NT 22 0.16 39 0.20 20 0.17 60 0.20
36 0.13 40 <0.10 44 0.21 NT NT 30 0.10
56 <0.10 31 0.15 28 0.10 31 0.14 22 0.15
18 0.48 NT NT 17 0.57 15 0.43 16 0.46
NT NT 19 0.67 17 0.58 16 0.53 29 0.57
12 0.38 15 0.57 18 0.57 NT NT 14 0.47
14 0.61 19 0.58 16 0.55 14 0.47 16 0.43
104 NT
142 85
103
NT 123 154 111 118
98 118 107
NT 120
101 151
83 107
90
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
TRIG mg/dL
GLUC mg/dL
Individual Serum and Plasma Chemistry Values
TP g/dL
ALB g/dL
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
Female, Group: II - 0 mg/kg - Day 183
648356 648357 648405 648422 648431
70 109 7.8 NT NT NT 73 94 8.6 49 95 8.2 43 105 8.3
Female, Group: VI - 10 mg/kg - Day 183
648352 NT NT NT
648365
57 100 8.7
648384
95 118 8.7
648385
75 107 8.5
648413 146 102 8.6
Female, Group: VIII - 60 mg/kg - Day 183
648349
65 115 8.4
648360
83 113 7.8
648379
64 118 8.8
648386 NT NT NT
648415 144 120 8.9
Female, Group: X - 300 mg/kg - Day 183
648358
27 108 7.7
648367 262 119 9.3
648373 137 104 8.4
648391 131 107 9.1
648411
52 107 8.1
4.9 2.9 NT NT
5.6 3.0 5.4 2.8 6.0 2.3
NT NT 5.8 2.9 5.9 2.8 6.0 2.5 5.5 3.1
5.7 2.7 4.4 3.4 5.6 3.2
NT NT 6.0 2.9
5.0 2.7 6.3 3.0 5.4 3.0 5.9 3.2 5.6 2.5
11.2 NT
11.7 11.4 12.0
NT 11.7 11.8 11.3 12.0
11.2 11.5 11.7
NT 12.1
11.3 12.3 11.5 11.6 11.5
4.1 142.8 NT NT
4.6 143.6 5.0 146.3 5.3 143.9
NT NT 4.2 144.2 7.0 144.8 3.7 143.4 5.3 142.4
4.9 145.7 5.6 148.2 5.3 143.6
NT NT 5.0 144.5
4.9 145.0 5.2 144.2 4.2 145.2 4.6 144.3 5.7 142.9
K mmol/L
5.28 NT
5.55 5.51 5.44
NT 5.31 5.22 4.53 5.79
5.30 6.28 5.13
NT 5.77
5.27 5.63 5.62 5.05 5.36
CL mmol/L
100.0 NT
98.5 101.4
97.4
NT 99.5 102.8 99.7 98.9
99.7 103.2
96.6 NT
99.0
101.2 97.6 99.9 97.5
100.2
730
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
QUAL
COL CLAR
Male, Group: I - 0 mg/kg - Day 38
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR HAZY HAZY HAZY HAZY HAZY HAZY HAZY HAZY HAZY
Male, Group: III - 60 mg/kg - Day 38
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY HAZY HAZY HAZY HAZY HAZY CLOUDY HAZY HAZY HAZY
Male, Group: V - 10 mg/kg - Day 38
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY CLOUDY CLOUDY
HAZY HAZY CLOUDY CLEAR HAZY HAZY HAZY
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
PH
UGLU mg/dL
KET mg/dL
UBIL
BLD
21.8 9.0
14.2 18.0 20.6
7.0 11.4
1.4 15.2
6.0
10.2 10.0
4.8 13.8
8.0 30.0 24.0 14.2 13.2
7.0
9.0 10.6 11.4 11.8 14.8
8.0 5.0 12.0 12.0 8.8
425 1154
663 527 546 938 673 QNS 565 1381
1.014 1.037 1.021 1.017 1.019 1.030 1.022 1.060 1.019 1.043
814 1015
932 577 709 392 379 494 540 1115
1.026 1.034 1.029 1.019 1.023 1.013 1.013 1.016 1.018 1.037
874 789 658 636 707 795 1276 743 829 854
1.027 1.025 1.021 1.020 1.023 1.026 1.042 1.024 1.026 1.027
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
TRACE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE
TRACE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE
SMALL
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
731
Company Sanitized. Does not contain TSCA GBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________
)
)
DuPont-6554
Animal Number
QUAL
COL CLAR
Male, Group: VII - 60 mg/kg - Day 38
648223 648237 648243 648244 648259 648266 64827Q 648280 648300 648305
LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY CLEAR HAZY HAZY HAZY
CLOUDY HAZY HAZY HAZY HAZY
Male, Group: IX - 300 mg/kg - Day 38
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY HAZY CLEAR HAZY HAZY HAZY CLEAR CLOUDY CLOUDY CLOUDY
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
10.2 12.0
9.2 7.0 8.0 6.8 22.0 17.2 7.6 8.0
17.8 40.0
7.0 11.0 18.0
7.2 21.8
9.8 14.8 12.2
810 826 597 845 976 1125 408 453 638 1271
1.026 1.027 1.020 1.027 1.031 1.037 1.014 1.015 1.021 1.040
584 259 1418 486 455 797 302 1171 501 666
1.019 1.009 1.046 1.016 1.015 1.025 1.010 1.038 1.016 1.022
7.5 NEGATIVE
5 NEGATIVE
TRACE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
8.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE MODERATE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE
SMALL
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE
SMALL
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
732
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
URO EU/dL
UMTP mg/dL
SPEC
Individual Urinalysis Values
Male, Group: I - 0 mg/kg - Day 38
648220
0.2
21
648225
0.2
95
648238
0.2
23
648246
0.2
22
648247 0.2 128
648255
0.2
64
648256
0.2
24
648294 0.2 QNS
648307
0.2
90
648315 0.2 113
Male, Group: III - 60 mg/kg - Day :
648227
0.2
52
648232
0.2
73
648252
0.2
67
648258
0.2
23
648269 0.2 124
648274
0.2
14
648290
0.2
84
648299
0.2
24
648302
0.2
22
648303
0.2
90
Male, Group: V - 10 mg/kg - Day 38
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
0.2 0.2 0.2 0.2 0.2 0.2 . 0.2 0.2 0.2 0.2
79 28 26 24 35 116 53 27 61 43
FECAL CONTAMINATION OBSERVED
DuPont-6554
733
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
URO EU/dL
UMTP irtg/dL
SPEC
Individual Urinalysis Values
Male, Group: VII - 60 mg/kg - Day 38
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
52 36 32 67 FECAL CONTAMINATION OBSERVED 61 61 15 24 56 56
Male, Group: IX - 300 mg/kg - Day 38
648217
0.2
34
648218
0.2
9
648235 0.2 192
648236
0.2
24
648239
0.2
18
648248
0.2
27
648275
0.2
15
648289 0.2 112
648293
0.2
28
648308
0.2
26
DuPont-6554
734
Company Sanitized. Does not contain TSCA C81
)) )
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________________________________ ______________________________________ ______________ DuPont-6554
Animal Number
QUAL
COL CLAR
Male, Group: 1 - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
LIGHT LIGHT MEDIUM LIGHT MEDIUM MEDIUM MEDIUM
NT LIGHT MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
NT YELLOW YELLOW
HAZY HAZY CLEAR CLEAR HAZY CLEAR HAZY
NT HAZY CLEAR
Male, Group: III - 60 mg/kg - Day 92
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
MEDIUM LIGHT
MEDIUM MEDIUM
LIGHT LIGHT LIGHT MEDIUM MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR HAZY HAZY HAZY HAZY
CLEAR HAZY
CLEAR CLEAR CLOUDY
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY HAZY HAZY HAZY
CLEAR CLEAR
HAZY CLEAR CLEAR CLEAR
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
14.6 6.4 3.8
10.8 5.2 7.2 6.4 NSR 6.0 3.2
750 706 1693 767 , 1233 1043 1174
NT 882 ENV
1.021 1.023 1.052 1.024 1.041 1.034 1.037
NT 1.029 1.061
6.0 8.2 2.8 5.0 5.0 7.0 17.2 3.4 3.6 1.3
1325 1060 1963 1442
987 822 638 1950 1730 QNS
1.043 1.035 1.059 1.046 1.031 1.026 1.022 1.059 1.056 1.082
13.4 10.0
9.8 13.0 17.0
4.6 2.0 8.0 4.4 5.0
650 1248
794 753 566 1311 QNS 1306 1831 1455
1.021 1.041 1.024 1.023 1.018 1.043 1.076 1.040 1.057 1.047
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE
15 NEGATIVE MODERATE
NT NT NT NT NT
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
735
Company Sanitized. Does not contain TSCA CBS
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats___________________________________________________________ ______________________________ DuPont-6554
Animal Number
QUAL
COL CLAR
Male, Group: VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY HAZY HAZY CLEAR HAZY CLEAR HAZY CLEAR CLEAR CLEAR
Male, Group: IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
MEDIUM LIGHT LIGHT LIGHT
MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY CLEAR
HAZY CLEAR
HAZY CLEAR
HAZY CLEAR CLEAR CLEAR
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
4.2 8.8 3.2 4.0 6.4 4.8 13.4 11.6 4.8 9.0
11.0 29.0 29.0 14.0 12.6
3.4 11.2
4.8 8.4 12.8
1124 1162 1687 1385 1021 1470
680 723 1097 809
1.039 1.037 1.053 1.046 1.033 1.048 1.022 1.023 1.035 1.026
783 465 400 737 874 901 763 1679 818 879
1.024 1.014 1.013 1.022 1.027 1.028 1.023 1.052 1.026 1.026
6.5 NEGATIVE
5 NEGATIVE
SMALL
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE
TRACE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE
TRACE
736
Company Sanitized. Does not contain TSCA CBS
)))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________________________________________ _______________________________DuPont-6554
Animal Number
URO EU/dL
UFLU
mu
UMTP mg/dL
Male, Group: I - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
0.2 10.5 0.2 2.1 0.2 7.2 0.2 9.8 0.2 7.5 0.2 8.9 0.2 10.5
NT NSR 0.2 5.8 0.2 QNS
Male, Group: III - 60 mg/kg - Day 92
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
0.2 8.4 0.2 9.9 0.2 QNS 0.2 7.9 0.2 6.2 0.2 6.2 0.2 14.5 0.2 7.8 0.2 QNS 0.2 QNS
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
0.2 20.6 0.2 27.4 0.2 19.6 0.2 20.3 0.2 20.7 0.2 11.8 0.2 QNS 0.2 25.3 0.2 8.8 0.2 17.0
42 42 108 37 294 56 71 NT 145 150
82 62 136 146 176 40 104 184 164 QNS
52 34 30 25 24 180 QNS 49 216 82
Individual Urinalysis Values SPEC
737
Company Sanitized. Does not contain TSCA CB1
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
URO EU/dL
UFLU Mg
UMTP mg/dL
Male, Group: VII - 60 mg/kg - Day 92
648223 648237 648243 648244 648259 648266 648270 648280 648300 648305
0.2 43.9 0.2 77.9 0.2 41.6 0.2 44.2 0.2 41.1 0.2 41.6 0.2 59.3 0.2 52.9 0.2 50.2 0.2 47.9
Male, Group : IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
0.2 159.3 0.2 185.4 0.2 231.2 0.2 146.4 0.2 180.9 0.2 47.2 0.2 148.6 0.2 144.8 0.2 106.4 0.2 242.1
136 55
167 137
96 83 38 32 94 47
49 13 17 30 53 35 41 156 41 44
Individual Urinalysis Values
DuPont-6554
738
Company Sanitized Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats___________
)
)
________________ DuPont-6554
Animal Number
QUAL
COL CLAR
Male, Group: I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY CLEAR HAZY HAZY CLEAR CLEAR
CLOUDY CLEAR CLEAR HAZY
Male, Group: IX - 300 mg/kg - Day 122
648216 648230 648241 648249 648261 648262 648282 648284 648306
MEDIUM LIGHT LIGHT
MEDIUM LIGHT
MEDIUM MEDIUM
LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY CLEAR CLEAR CLEAR CLEAR
HAZY CLOUDY
CLEAR CLEAR
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
1.9 5.4 4.7 6.4 18.4 8.0 4.1 22.0 9.2 2.5
1.5 32.0 18.6
3.1 11.6
1.5 4.8 10.4 21.0
QNS 1269 2060 1262
708 1086 1411
561 1104
QNS
>1.083 1.041 1.061 1.041 1.021 1.035 1.046 1.016 1.036 1.066
QNS 409 658 1412 1016 QNS 1627 976 569
1.072 1.016 1.020 1.044 1.029 1.075 1.051 1.033 1.018
7.0 NEGATIVE
5 SMALL NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
15 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
7.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE
TRACE
7.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE
TRACE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.0 NEGATIVE
5 SMALL NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
739
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
URO EU/dL
UFIiU Mg
UMTP mg/dL
Male, Group: I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277 648278 648311
0.2 QNS 0.2 8.4 0.2 13.9 0.2 10.7 0.2 19.3 0.2 9.8 0.2 3.2 0.2 26.8 0.2 10.3 0.2 5.7
110 85
145 100 182
52 284
16 198 151
Male, Group: IX - 300 mg/kg - Day 122
648216 648230 648241 648249 648261 648262 648282 648284 648306
0.2 QNS 0.2 34.3 0.2 34.4 0.2 11.4 0.2 31.3 0.2 QNS 0.2 18.4 0.2 22.4 0.2 30.7
192 10 21 85 26
147 161
30 20
Individual Urinalysis Values SPEC
DuPont-6554
740
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
QUAL
COL CLAR
Male, Group: I - 0 rag/kg - Day 183
648219 648226 648228 648297 648298
LIGHT LIGHT LIGHT LIGHT MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY HAZY CLEAR CLEAR HAZY
Male, Group: V - 10 mg/kg - Day 183
648253 648254 648265 648283 648310
LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR CLOUDY CLEAR
Male, Group: VII - 60 mg/kg - Day 183
648268 648279 648285 648296 648314
LIGHT LIGHT MEDIUM LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW
'
CLEAR CLEAR
HAZY CLEAR CLEAR
Male, Group: IX - 300 mg/kg - Day 183
648234 648240 648272 648287 648292
LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR
HAZY CLEAR
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG UFLU M9
UMTP mg/dL
10.0 19.0
3.2 4.1 2.0
16.4 6.6 3.2 5.2
17.8
8.4 4.3 2.0 12.8 12.8
6.6 7.3 11.0 17.4 16.0
795 536 2657 1628 QNS
1.024 1.015 1.066 1.046 >1.083
612 1449 2172 1852
510
1.019 1.040 1.070 1.048 1.016
1265 1561 3211
950 706
1.040 1.043 >1.083 1.028 1.024
1130 1077
712 567 616
1.034 1.030 1.021 1.018 1.020
13.6 17.3 11.8
8.3 QNS
15.5 15.0
9.1 13.7 16.7
18.6 10.4
QNS 21.8 13.2
15.6 17.5 18.2 24.7 21.1
75 18 191 144 155
14 63 102 132 105
585 62
132 106 390
76 35 20 19 23
SPEC
DuPont-6554
741
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
QUAL
COL CLAR
Female, Group : II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY CLOUDY CLOUDY
CLEAR HAZY HAZY HAZY HAZY HAZY
CLOUDY
Female, Group : IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
LIGHT MEDIUM
LIGHT MEDIUM MEDIUM MEDIUM
LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY HAZY HAZY
CLOUDY HAZY HAZY
CLEAR HAZY HAZY HAZY
Female, Group : VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
LIGHT LIGHT MEDIUM LIGHT LIGHT MEDIUM LIGHT LIGHT MEDIUM LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY CLEAR
CLOUDY HAZY
CLOUDY HAZY HAZY
CLEAR CLOUDY
HAZY
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
8.0 5.4 8.0 9.4 12.0 2.8 8.1 4.8 16.9 18.7
9.6 3.7 4.5 4.2 2.6 2.1 6.5 10.0 8.6 5.9
2.1 7.7 5.4 8.0 3.9 3.4 7.5 3.7 2.0 2.1
682 1309
823 630 662 2157 931 959 410 408
1.021 1.040 1.025 1.019 1.020 1.062 1.028 1.030 1.013 1.013
729 1500 1099 1384 1684 2422
865 722 594 981
1.022 1.044 1.034 1.045 1.051 1.068 1.026 1.023 1.019 1.029
1605 679
1035 685
1124 1898
891 1684 1833 1322
1.049 1.022 1.031 1.021 1.035 1.054 1.027 1.052 1.056 1.041
8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
8.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE
5 NEGATIVE
TRACE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
742
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
QUAL
COL CLAR
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY HAZY
CLOUDY CLEAR HAZY HAZY
CLOUDY CLOUDY CLOUDY CLOUDY
Female, Group: X - 300 mg/kg - Day 39
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY HAZY CLEAR HAZY HAZY CLEAR HAZY HAZY CLOUDY CLEAR
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
9.2 4.7 3.1 2.4 19.3 2.9 12.0 4.5 12.9 8.6
19.4 13.4
9.2 22.0
4.4 8.8 3.7 18.0 17.8 5.8
830 1049 1179 1841
369 1280
543 873 708 580
1.025 1.031 1.037 1.055 1.012 1.040 1.017 1.026 1.022 1.018
390 462 932 318 1596 835 1604 393 472 954
1.013 1.015 1.028 1.010 1.047 1.026 1.049 1.013 1.015 1.029
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE
5 NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
7.5 NEGATIVE NEGATIVE NEGATIVE
SMALL
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
743
Company Sanitized. Does not contain TSCA C8I
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats____________________________________________________________________________________________ DuPont-6554
Animal Number
URO EU/dL
UMTP mg/dL
SPEC
Individual Urinalysis Values
Female, Group: II - 0 mg/kg -- Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
18 42 21 11
9 55 17 16
6 11
Female, Group : IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
16 32 49 45 FECAL CONTAMINATION OBSERVED 40 65 15 15 12 17
Female, Group: VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
28 13 28 FECAL CONTAMINATION OBSERVED 14 20 29 13 42 81 FECAL CONTAMINATION OBSERVED 31
744
Company Sanitized. Does not contain TSCA CBI
))
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats__________________________________________________________________________________ _____________________DuPont-6554
Animal Number
URO EU/dL
UMTP mg/dL
SPEC
Individual Urinalysis Values
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
21 21 FECAL CONTAMINATION OBSERVED 25 35
8 38 12 17 15 FECAL CONTAMINATION OBSERVED 16
nale. Group: X - 300 mg/kg - Day 39
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
11 11 41 FECAL CONTAMINATION OBSERVED 10 FECAL CONTAMINATION OBSERVED 36 16 40
9 13 FECAL CONTAMINATION OBSERVED 29
745
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats________________________________________________________ ____________________ ______________ DuPont-6554
Animal Number
QUAL
COL CLAR
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
MEDIUM NT
MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM
YELLOW NT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR NT
CLOUDY HAZY HAZY
CLEAR HAZY
CLEAR CLEAR
HAZY
Female, Group : IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
LIGHT MEDIUM MEDIUM MEDIUM
NT MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW
NT YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR CLEAR
NT HAZY CLEAR CLEAR CLEAR CLEAR
Female, Group : VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
NT MEDIUM
LIGHT MEDIUM MEDIUM
RED YELLOW YELLOW YELLOW YELLOW
NT YELLOW YELLOW YELLOW YELLOW
CLOUDY HAZY
CLEAR CLEAR CLEAR
NT CLEAR CLEAR
HAZY HAZY
Individual Urinalysis Values
VOL U0SM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
1.6 QNS 2.7 3.0 5.6 1.9 9.0 2.1 10.0 2.8
6.4 2.0 3.4 5.0 QNS 1.4 2.6 7.6 3.5 3.7
1.4 4.8 1.7 1.0 2.8 QNS 2.8 18.0 2.2 3.7
QNS QNS 1595 2179 829 QNS 918 QNS 614 1310
1.050 NT
1.049 1.062 1.025 1.057 1.027 1.051 1.020 1.042
844 QNS 1574 1269 QNS QNS 1320 693 1281 1141
1.027 1.052 1.048 1.039
NT 1.078 1.042 1.021 1.040 1.036
QNS 1232
QNS QNS 1741 QNS 1207 374 QNS 1181
1.050 1.038 1.055 >1.083 1.053
NT 1.037 1.011 1.055 1.036
5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT NT NT NT NT 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE MODERATE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.0 NEGATIVE NEGATIVE
SMALL NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NT NT NT NT NT
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
746
Company Sanitized. Doss not contain TSCA CBi
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
QUAL
COL CLAR
Female, Group : VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR
CLOUDY CLEAR CLEAR
Female, Group : X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM
DARK LIGHT MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
RED YELLOW YELLOW
CLEAR HAZY
CLEAR CLEAR CLEAR
HAZY CLEAR TURBID
HAZY CLEAR
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
4.7 1.6 4.0 4.5 18.8 1.2 22.0 1.0 11.0 7.0
7.8 3.9 2.3 4.5 8.0 6.6 4.4 3.0 7.0 3.3
1219 QNS
1092 1375
408 QNS 365 QNS 789 981
1.038 1.058 1.034 1.042 1.014 1.060 1.012 1.060 1.025 1.028
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE
TRACE
6.0 NEGATIVE NEGATIVE NEGATIVE
TRACE
5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
991 1785
QNS 1114
944 1049 1184 2404 1003 1210
1.030 1.053 1.058 1.035 1.028 1.031 1.038 1.060 1.030 1.039
5.5 6.5 5.5 6.0 6.0 6.0 6.0 NT-INT 6.0 6.0
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE
LARGE NEGATIVE NEGATIVE
747
Company Sanitized. Does not contain TSCA CBI
>)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_______________________________________
Animal Number
URO EU/dL
UFLU M9
UMTP mg/dL
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
0.2 QNS NT QNS
0.2 QNS 0.2 QNS 0.2 5.4 0.2 QNS 0.2 8.7 0.2 QNS 0.2 .10.3 0.2 QNS
QNS QNS
68 132
14 QNS
14 QNS
13 61
Female, Group : IV - 60 mg/kg - Day 93
648364 0.2 7.2
20
648369 0.2 QNS QNS
648390 0.2 7.7
84
648396 0.2 5.8
42
648397
NT QNS QNS
648402 0.2 QNS QNS
648408 0.2 QNS
45
648409 0.2 8.2
12
648410 0.2 5.5
44
648424 0.2 4.9
38
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
0.2 QNS 0.2 10.2 0.2 QNS 0.2 QNS 0.2 QNS
NT QNS 0.2 QNS 0.2 10.6 0.2 QNS 0.2 7.1
QNS 28
QNS QNS
49 QNS
36 <6 QNS 28
Individual Urinalysis Values SPEC
FECAL CONTAMINATION OBSERVED
>
DuPont-6554
748
Company Sanitized. Does not contain TSCA CBI
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
')
Animal Number
URO EU/dL
UFLU Mg
UMTP mg/dL
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
0.2 27.6 0.2 QNS 0.2 20.1 0.2 23.5 0.2 36.6 0.2 QNS 0.2 31.2 0.2 QNS 0.2 44.8 0.2 29.0
34 QNS
38 35
8 QNS
<6 QNS
17 17
Female, Group: X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
0.2 0.2 0.2 0.2 0.2 0.2 0.2 NT-INT 0.2 0.2
97.2 84.3
QNS 86.5 100.9 102.6 92.7
QNS 78.9 52.6
19 66 52 39 17 18 41 322 20 38
Individual Urinalysis Values SPEC
FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED
) DuPont-6554
749
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-6554
Animal Number
QUAL
COL CLAR
Female, Group : II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR
HAZY HAZY CLEAR CLEAR CLEAR CLEAR CLOUDY CLEAR
Female, Group : X - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
MEDIUM MEDIUM MEDIUM MEDIUM
LIGHT MEDIUM MEDIUM MEDIUM
LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR CLEAR CLEAR
HAZY CLEAR CLEAR CLEAR
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG
pH
UGLU mg/dL
KET mg/dL
UBIL
BLD
6.4 3.4 1.3 3.0 9.6 4.5 13.0 5.1 4.4 7.2
3.7 7.0 8.4 3.5 9.0 6.0 11.0 3.2 12.0
607 987 QNS 2009 779 1121 834 884 1323 870
1.019 1.030 1.072 1.058 1.024 1.036 1.026 1.027 1.043 1.026
1244 643 813
1268 551
1132 675
1191 494
1.038 1.020 1.024 1.039 1.017 1.034 1.022 1.038 1.016
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.0 NEGATIVE NEGATIVE
SMALL NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE
750
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_________________________
Animal Number
URO EU/dL
UFLU
mu
UMTP mg/dL
Female, Group: II - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
0.2 6.5 0.2 7.5 0.2 QNS 0.2 8.1 0.2 9.6 0.2 8.3 0.2 10.5 0.2 8.0 0.2 9.2 0.2 11.9
39 26 66 46 16 185 23 33 380 84
Female, Group: X - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
0.2 13.8 0.2 11.0 0.2 16.1 0.2 11.0 0.2 13.0 0.2 2.5 0.2 18.4 0.2 10.4 0.2 8.9
38 16 10 35 10 25 12 28
9
Individual Urinalysis Values SPEC
FECAL CONTAMINATION OBSERVED
DuPont-6554
751
Company Sanitized. Does not contain TSCA CBi
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats___________________________
)
Animal Number
QUAL
COL CLAR
Female, Group : II - 0 mg/kg - Day :183
648356 648357 648405 648422 648431
MEDIUM LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW
CLOUDY CLEAR CLEAR CLEAR CLEAR
Female, Group:: VI - 10 mg/kg - Day 183
648352 648365 648384 648385 648413
NT LIGHT LIGHT LIGHT LIGHT
NT YELLOW YELLOW YELLOW YELLOW
NT CLOUDY
CLEAR CLEAR CLOUDY
Female, Group:: VIII - 60 mg/kg - Day 183
648349 648360 648379 648386 648415
LIGHT LIGHT LIGHT MEDIUM LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW
CLEAR CLEAR CLEAR CLOUDY CLEAR
Female, Group:: X - 300 mg/kg - Day 183
648358 648367 648373 648391 648411
LIGHT LIGHT LIGHT LIGHT LIGHT
YELLOW YELLOW YELLOW YELLOW YELLOW
HAZY CLEAR CLEAR CLEAR CLEAR
Individual Urinalysis Values
VOL UOSM mL mOsm/kg
SG UFLU Mg
UMTP mg/dL
0.4 11.8
1.3 2.7 6.0
NSR 5.4 4.6 4.4 11.1
10.4 8.4 7.0 0.3 7.7
5.8 3.4 7.8 7.0 6.8
QNS 648 1902 1518 958
>1.083 1.019 1.049 1.041 1.027
NT 841 1310 1040 558
NT 1.025 1.035 1.030 1.019
723 769 1017 QNS 933
1.020 1.022 1.027 >1.083 1.026
869 1365
874 862 810
1.025 1.038 1.025 1.025 1.024
QNS 12.6
QNS 6.9 7.8
NSR 7.4 7.9 6.5 9.2
12.9 10.9
9.2 QNS 11.4
11.2 7.2
13.1 13.0 10.1
QNS 72 53 45 19
NT 36 21 21 355
10 12 15 QNS 79
18 108
15 41 20
) DuPont-6554
CONTAMINATION OBSERVED
752
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
EPIT
UWBC
URBC
Individual Urine Microscopic Values
NCRY
MICR
SPER
SPEC
Male, Group: I - 0 mg/kg - Day 38
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
FEW NONE NONE
FEW FEW NONE FEW NONE NONE NONE
1-10 0 0
1-10 1-10
0 1-10 1-10
0 0
0 MANY MANY
0 FEW FEW
0 MODERATE
MANY
0 MODERATE MODERATE
0 FEW MODERATE
0 MODERATE
MANY
0 MODERATE
MANY
0 FEW FEW
0 FEW MODERATE
0 FEW FEW
Male, Group: III - 60 mg/kg - Day 38
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
NONE FEW FEW
NONE FEW
NONE FEW
NONE NONE NONE
0 1-10 1-10
0 1-10
0 0 0 0 0
0 FEW MODERATE
0 MODERATE
MANY
0 MANY MANY
0 FEW MANY
0 MODERATE
MANY
0 FEW FEW
0 MANY MANY
0 FEW MODERATE
0 FEW FEW
0 FEW FEW
Male, Group: V - 10 mg/kg - Day 38
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
FEW FEW NONE FEW NONE NONE FEW NONE NONE NONE
0 1-10
0 0 0 1-10 0 0 0 0
0 1-10
0 0 0 0 0 0 0 0
MANY MODERATE MODERATE MODERATE
FEW FEW MODERATE FEW FEW NONE
MANY MANY MODERATE MANY
FEW FEW MANY FEW MODERATE FEW
2 2 1 1 2 2 2 2 1 1
1 1 1-MUCUS 2 1 1 1 1 1 1 1
2 1 1 1 -MUCUS 1 1 1 2 1 1 1
DuPont-6554
753
Company Sanitized. Does not contain TSC CBS
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats_____________________________
)
Animal Number
EPIT
UWBC
URBC
Individual Urine Microscopic Values
NCRY
MICR
SPER
SPEC
Male, Group: VII - 60 mg/kg - Day 38
648223 648237
648243 648244 648259 648266 648270 648280 648300 648305
FEW NONE NONE
FEW NONE
FEW FEW NONE NONE NONE
0 0 0 1-10 0 1-10 0 0 0 0
1-10 0 0 0 0 0 0 0 0 0
FEW MODERATE
FEW MODERATE
FEW MANY MODERATE
FEW FEW FEW
MODERATE MANY MANY MANY
MODERATE MANY MANY FEW FEW
MODERATE
Male, Group: IX - 300 mg/kg - Day 38
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
NONE NONE
FEW NONE NONE
FEW FEW FEW FEW FEW
0 0 1-10 0 1-10 0 0 1-10 1-10 0
0 0 0 0 1-10 0 0 1-10 0 0
FEW NONE MODERATE
FEW FEW NONE FEW MANY MODERATE FEW
FEW FEW MANY FEW MODERATE MODERATE MODERATE MANY MANY MODERATE
1 3 1-MUCUS 1 1-MUCUS 2 1 1 1 1 1 1
1 1 2 1 1 1 1 2 2 1
)
DuPont-6554
754
Company Sanitized. Does not contain TSCA CBl
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
EPIT
UWBC
URBC
Individual Urine Microscopic Values
NCRY
MICR
SPER
SPEC
Male, Group: I - 0 mg/kg - Day 92
648220 648225 648238 648246 648247 648255 648256 648294 648307 648315
NONE NONE NONE NONE
FEW FEW NONE
NT NONE NONE
0 0 0 0 0 0 0 NT 0 0
Male, Group : III - 60 mg/kg - Day 92
648227 648232 648252 648258 648269 648274 648290 648299 648302 648303
NONE FEW FEW
NONE FEW
NONE FEW
NONE NONE NONE
0 0 0 0 0 0 0 0 0 1-10
Male, Group: V - 10 mg/kg - Day 92
648221 648224 648245 648273 648286 648288 648301 648309 648312 648313
FEW NONE NONE NONE NONE NONE NONE NONE NONE
FEW
0 0 0 0 0 0 0 0 0 0
0 FEW MODERATE
0 FEW FEW
0 NONE
FEW
0 NONE
FEW
0 NONE
FEW
0 NONE
FEW
0 MODERATE MODERATE
NT NT NT
0 FEW FEW
0 FEW FEW
0 NONE
FEW
0 NONE
FEW
0 FEW FEW
0 NONE
FEW
0 FEW FEW
0 FEW MODERATE
0 NONE
FEW
0 MODERATE
NONE
0 NONE
FEW
0 NONE
FEW
0 NONE MODERATE
0 FEW MODERATE
0 FEW FEW
0 NONE
FEW
0 NONE
FEW.
0 NONE MODERATE
0 NONE NONE
0 FEW FEW
0 NONE
FEW
0 FEW FEW
i 2 1 1 1 1 1 NT 0 2
1 2 3 2 1 2 1 0 1 3
2 2 1 1 1 2 3 1 1 1
DuPont-6554
755
Company Sanitized, Does not contain TSCA CBi
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
EPIT
UWBC
URBC
Individual Urine Microscopic Values
NCRY
MICR
SPER
Male, Group: VII - 60 mg/kg - Day 92
648223
NONE
0
0
648237
FEW
0
0
648243
NONE
0
0
648244
NONE
0
0
648259
NONE
0
0
648266
NONE
00
648270
NONE
00
648280
NONE
0
0
648300
NONE
0
0
648305
NONE
0
0
Male, Group: IX - 300 mg/kg - Day 92
648217 648218 648235 648236 648239 648248 648275 648289 648293 648308
NONE NONE NONE
FEW NONE
FEW NONE NONE NONE NONE
00 00 00 00 00 00 00 00 00 0 1-10
FEW MODERATE
NONE NONE
FEW NONE
FEW NONE
FEW MODERATE
NONE NONE NONE
FEW NONE NONE NONE
FEW NONE NONE
FEW MODERATE
FEW MODERATE
FEW FEW MODERATE FEW MODERATE MODERATE
MODERATE FEW
MODERATE FEW
MODERATE FEW FEW
NONE FEW
NONE
1 2 3 2 2 2 1 1 0 1
2 1 1 1 0 1 0 1 1 2
) DuPont-6554
756
Company Sanitized. Does not contain TSCA CBS
H -24678: Subchronic T oxicity 90-Day Oral Gavage Study in Rats
Animal Number
EPIT
UWBC
URBC
Individual Urine Microscopic Values
NCRY
MICR
SPER
SPEC
Male, Group: I - 0 mg/kg - Day 122
648222 648233 648250 648257 648260 648264 648271 648277
648278 648311
FEW FEW FEW
NT NONE
FEW FEW NONE FEW FEW
1-10 1-10 1-10
NT 1-10
0 1-10
0 1-10 1-10
0 MODERATE 0 FEW 0 FEW NT NT 0 NONE 0 FEW 0 MODERATE 0 NONE 0 FEW 0 FEW
Male, Group: IX - 300 mg/kg - Day 122
648216 648230 648241 648249 648261 648262 648282 648284 648306
FEW FEW FEW FEW NONE FEW FEW NONE NONE
0 0 1-10 1-10 0 1-10 1-10 1-10 1-10
0 0 0 1-10 0 0 0 0 0
MODERATE FEW FEW FEW
NONE FEW FEW
NONE FEW
FEW FEW FEW
NT FEW FEW FEW FEW FEW FEW
FEW FEW FEW FEW FEW FEW FEW FEW FEW
3 2 3 NT 1 1-MUCUS 1 3 FEW FINELY GRANULAR CASTS 2 2 FEW FINELY GRANULAR CASTS 3
3 3 0 3 1 3 3 1 2
DuPont-6554
757
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
EPIT
UWBC
URBC
Individual Urine Microscopic Values
NCRY
MICR
SPER
SPEC
Female, Group: II - 0 mg/kg - Day 39
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
FEW NONE
FEW FEW FEW FEW FEW NONE FEW FEW
1-10 0
1-10 1-10 1-10 1-10
0 1-10 1-10 1-10
Female, Group: IV - 60 mg/kg - Day 39
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
NONE FEW
NONE FEW FEW FEW
NONE FEW FEW FEW
0 0 0 1-10 0 0 0 0 1-10 1-10
Female, Group: VI - 10 mg/kg - Day 39
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
NONE FEW FEW
NONE NONE
FEW NONE
FEW FEW FEW
0 1-10
0 0 0 1-10 0 0 1-10 1-10
0 FEW MODERATE
0 MANY MODERATE
0 MANY MANY
0 NONE
FEW
0 FEW FEW
0 FEW FEW
0 FEW MODERATE
0 NONE
FEW
0 FEW FEW
0 FEW MODERATE
0 MODERATE MODERATE
0 FEW FEW
0 MODERATE MODERATE
0 MODERATE MODERATE
0 FEW FEW
0 MODERATE
FEW
0 NONE
FEW
0 MODERATE MODERATE
0 MODERATE
FEW
0 FEW MODERATE
0 MANY MANY
0 FEW FEW
0 MANY MANY
0 NONE MODERATE
0 MODERATE
MANY
0 NONE
FEW
0 NONE
FEW
0 FEW FEW
0 FEW MODERATE
0 MODERATE
MANY
0 0 0 0 0 0 0 0 ,0 0
0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0
DuPont-6554
758
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
EPIT
UWBC
URBC
Individual Urine Microscopic Values
NCRY
MICR
SPER
Female, Group: VIII - 60 mg/kg - Day 39
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
FEW FEW FEW NONE NONE FEW NONE NONE FEW FEW
1-10 1-10
0 1-10
0 1-10
0 0 1-10 1-10
0 0 0 0 0 0 0 0 0 0
Female, Group: X - 300 mg/kg - Day 39
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
NONE FEW FEW FEW FEW
NONE FEW
NONE FEW
NONE
1-10 1-10 1-10
0 1-10
0 1-10
0 1-10
0
0 0 0 0 0 0 0 0 0 0
FEW NONE MANY
FEW NONE
FEW NONE MANY
FEW FEW
MODERATE FEW FEW FEW FEW
MANY NONE MODERATE
FEW MODERATE
MODERATE FEW
MANY FEW FEW
MODERATE MANY
MODERATE FEW FEW
MODERATE FEW FEW FEW FEW
MODERATE FEW FEW
MODERATE MODERATE
0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0
DuPont-6554
759
Company Sanitized. Does not contain TSCA CBI
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
EPIT
UWBC
URBC
Individual Urine Microscopic Values
NCRY
MICR
SPER
Female, Group: II - 0 mg/kg - Day 93
648351 648353 648370 648372 648393 648395 648421 648423 648430 648436
NONE NT
NONE NONE NONE NONE NONE NONE NONE NONE
0 NT
0 0 0 1-10 1-10 0 1-10 0
0 NONE
FEW
NT NT NT
0 MODERATE MODERATE
0 FEW FEW
0 NONE
FEW
0 NONE
FEW
0 NONE NONE
0 NONE
FEW
0 NONE
FEW
0 NONE
FEW
Female, Group: IV - 60 mg/kg - Day 93
648364 648369 648390 648396 648397 648402 648408 648409 648410 648424
NONE NONE NONE NONE
NT NONE NONE NONE NONE NONE
0 1-10
0 0 NT 0 0 0 0 0
0 NONE
FEW
0 NONE NONE
0 NONE
FEW
0 FEW NONE
NT NT NT
0 NONE
FEW
0 NONE
FEW
0 NONE
FEW
0 NONE
FEW
0 NONE
FEW
Female, Group: VI - 10 mg/kg - Day 93
648345 648366 648374 648382 648403 648406 648414 648429 648433 648441
FEW NONE NONE NONE NONE
NT FEW FEW NONE FEW
0 0 0 1-10 0 NT 0 0 0 0
0 MODERATE MODERATE
0 NONE
FEW
0 NONE
FEW
0 NONE NONE
0 NONE
FEW
NT NT NT
0 NONE NONE
0 NONE NONE
0 FEW FEW
0 NONE NONE
0 NT
0 0 0 0 0 0 0 0
0 0 0 0 NT 0 0 0 0 0
0 0 0 0 0 NT 0 0 0 0
DuPont-6554
760
Company Sanitized. Does not contain TSCA CBf
)
H-24678: Subchronic Toxicity 90-Day Oral Gavage Study in Rats
)
Animal Number
EPIT
UWBC
URBC
Female, Group: VIII - 60 mg/kg - Day 93
648348 648354 648362 648368 648380 648381 648401 648417 648432 648440
NONE NONE NONE NONE NONE
FEW NONE NONE NONE NONE
0 0 0 0 0 0 0 0 1-10 0
0 0 0 0 0 0 0 0 0 0
Female, Group: X - 300 mg/kg - Day 93
648347 648363 648376 648388 648392 648400 648407 648412 648435 648438
FEW NONE
FEW NONE
FEW NONE NONE NONE NONE NONE
1 O
0 0 0 0 0 0 0
0 1-10
0 0 0 0 0 0 0 >50 0 0
Individual Urine Microscopic Values
NCRY
MICE
SPER
FEW FEW NONE NONE FEW NONE NONE FEW NONE NONE
MODERATE FEW FEW FEW FEW FEW FEW
MODERATE NONE FEW
NONE NONE NONE NONE NONE NONE NONE NONE
FEW NONE
NONE FEW FEW FEW
NONE FEW FEW FEW FEW
NONE
0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0
) DuPont-6554
761
Corapanf Sanitized. Does not contain TSCA CB
H-24678: Subchronic Toxicity 90-Day Otai Gavage Study in Rats
Animal Number
EPIT
UWBC
URBC
Female, Group: IX - 0 mg/kg - Day 122
648346 648355 648389 648394 648404 648425 648426 648434 648439 648442
FEW FEW FEW FEW FEW FEW NONE FEW FEW FEW
0 1-10 1-10
0 0 0 1-10 0 0 0
Female, Group: X - 300 mg/kg - Day 122
648350 648359 648378 648383 648387 648398 648399 648419 648427
NONE FEW FEW FEW FEW FEW FEW FEW FEW
0 0 0 1-10 0 0 0 0 0
0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0
Individual Urine Microscopic
NCRY
MICR
SPER
NONE NONE NONE NONE NONE
FEW NONE NONE
FEW NONE
FEW NONE NONE NONE NONE
FEW NONE
FEW NONE
FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW
FEW FEW FEW FEW FEW FEW FEW FEW FEW
0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0
762
Values SPEC
DuPont-6554
1-MUCUS 1-MUCUS
Company Sanitized. Does not contain TSCA CBS
